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<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR84</accession>
    <name>L7JR84_TRAHO</name>
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            <fullName evidence="5">40S ribosomal protein S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_3123</name>
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    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
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            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
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    <dbReference type="HOGENOM" id="CLU_115574_2_0_1"/>
    <dbReference type="InParanoid" id="L7JR84"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
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    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
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    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ73983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="94" mass="10205" checksum="8F6F8C5A17139810" modified="2013-03-06" version="1">MILTFSGVEAKQPNSAVRKAVRIQLCGTGKKIIAFVPYDGGLNYIEHNDEVTVMGCGKKGRSVGDIPGIRYKVCKVQGVAIKSLVTKKKQKPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRF5</accession>
    <name>L7JRF5_TRAHO</name>
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        <recommendedName>
            <fullName evidence="5">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3005"/>
    <dbReference type="HOGENOM" id="CLU_1983127_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRF5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979065" description="Transposable element encoded protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14312" checksum="6E9428E122316A60" modified="2013-03-06" version="1">MHGMVPFHSIILHLSLFVSTSLPNHCITDQNDTTVSNDTSGVVLYRAAPCNFRNYAAGMFTNMKTESKIGLYYVSVLMVILIAIGIFFLYRCCKRRTQSDHTLQVTYRSPVREERSESIVELSIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRH6</accession>
    <name>L7JRH6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3202"/>
    <dbReference type="HOGENOM" id="CLU_2777704_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRH6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="69" mass="7587" checksum="DA90E4C1C1128722" modified="2013-03-06" version="1">MNFGFMLISIFHGHGETIGCFIAGMLICGSSFLDVDLFMVPDKITNLTHISTITYILSLLPASFLLAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRI3</accession>
    <name>L7JRI3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3173"/>
    <dbReference type="HOGENOM" id="CLU_617040_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRI3"/>
    <dbReference type="OrthoDB" id="10526234at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="444" mass="49973" checksum="6AAE88B7CF5E5E6F" modified="2013-03-06" version="1">MFINEEHKKNKQIKNESIKRTEKESNAHNQEIRDDNASARDEGMGSANAYKTAHDYTPYAKEPPTAHEQMSHPPPVRSVHPSVAQPSSSVNMNWSNFSVYQHLTGVPESMHSNGFGSLNDIFRRSAGNTFLEINEENNNEVGEEEGVGVCNSNQVSINNNNKVSNDNNKVSINNNNNLNGINNNNLNGINTNNKVSINTNLNNNNNLNGINNNNNTINVVNASINEQVIINDDTYENERKVREQKEGGDIKRIKVDDNYGKGSNDNYSNLTIPTTITAPSPTTPVLTTIANAKPFLNNLILDVINQKITKHKAQELLQKNNLTIKEYNSTIKEILRTKMYYQNRMSTAIGGECLRTDEMLDDTFLKDVVHSSTGTCSVGDKECFINTFYQTRKILGKKELLNVFAEKCGEERVSYDAKDVHVLERALHFHLRRVMERISEEGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRN6</accession>
    <name>L7JRN6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2990"/>
    <dbReference type="HOGENOM" id="CLU_1062401_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRN6"/>
    <dbReference type="OMA" id="IILWMKI"/>
    <dbReference type="OrthoDB" id="2191249at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="262" mass="30193" checksum="8D53819B48BF74AB" modified="2013-03-06" version="1">MMTKHPLFHCSKPDTPKLLFTSSHVDIKGENIQSFHINMVIDNLYAIPNYLLIQQSSTIIIYRYKIKNTKGNKNRIILAKIKKIENHILNYLVNRVSRQVLRLLFNVMLTLVSKNVKACNREMEKIILWMKISDIVDVHIGECVKVWDRYGVVKTYYNDASDGEQIAERRDDKNKTDDKGGKQYAAKDNAKETMSDQSSSVSLTKLVNDNFSLECKNNKLRMNYFKRSFVENLNLVGVVDFVCVNSTVFVLLKSGVEVLLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS11</accession>
    <name>L7JS11_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2830"/>
    <dbReference type="HOGENOM" id="CLU_3056298_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS11"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="5554" checksum="1269245FBCD43898" modified="2013-03-06" version="1" fragment="single">VSIGTGITEVVPTHLRCVVASASCFNDTSRIRAIVFLYFLGEGGGAANSKPASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS68</accession>
    <name>L7JS68_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2836"/>
    <dbReference type="HOGENOM" id="CLU_2110653_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS68"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="115" mass="13466" checksum="6981BD3CE384C370" modified="2013-03-06" version="1">MECTINMVEQKLKERNIRNDKSKCKLIRETGKVETVMKLKKLITTNYQLTDEWRTFIKLRTRNFSSCTRLAKLGYIDNKYATECICCHKKNRKQSSTSCGCVRCGKTSERTILDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS84</accession>
    <name>L7JS84_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2924"/>
    <dbReference type="HOGENOM" id="CLU_2887430_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS84"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="63" mass="6679" checksum="D1C832FA806EA0CD" modified="2013-03-06" version="1">MADKKKTIIIGCVVGVLVLIILIALGFYFFGSSGDGSKGSRWSSMFGTSSSSDDKNKTTKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT65</accession>
    <name>L7JT65_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SAM-dependent methyltransferase/cell division protein FtsJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT65"/>
    <dbReference type="FunCoup" id="L7JT65">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2534"/>
    <dbReference type="HOGENOM" id="CLU_009422_1_2_1"/>
    <dbReference type="InParanoid" id="L7JT65"/>
    <dbReference type="OMA" id="YDDMIND"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106339">
        <property type="term" value="F:tRNA (cytidine(32)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002130">
        <property type="term" value="P:wobble position ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="249" mass="27759" checksum="8861917DBCF9D145" modified="2013-03-06" version="1">MAKENGYRARSAYKIQQIDEHYKILHGNTTVIDLCAAPGGWTQIIAEKCTKVIAVDIQTILPIEGVVFIRDDITSDSCVKSVLEHVHLLNNSENAKADLVLCDGASNTSGMLDVDVHVQHSILQAALKLAEKISKVCSTFVGKLYRNGDIGTVLRQFSEVYERVELVKPKCSRSQSIECFVIAMSKRREPLKLCKDYTPIFECLSVGNGPDPDINTEEEMLSAVKHRFPPISPPYKKAIEKRKRNQGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTH4</accession>
    <name>L7JTH4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Replication factor C, subunit RFC2</fullName>
            <ecNumber evidence="6">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="6"/>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTH4"/>
    <dbReference type="FunCoup" id="L7JTH4">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2324"/>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="InParanoid" id="L7JTH4"/>
    <dbReference type="OMA" id="LCLANQM"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="42"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="309" mass="34977" checksum="559472F0EA50302A" modified="2013-03-06" version="1" fragment="single">VVKGAPMHENLLTEKYRPRKIGDVVGNHETIESIQSILNANSMPHLLFSGPPGTGKITVAKIIAEKIVNDKKYILELNASDERGIDTVRTTIKNFSMRLSTGLKVIILDECDSMTVAAQQAMRRTMETSTADCRFILVCNNIQKISEPIQSRCAIFTFNKIKNEDMKTRLNEIISDENLNMSDEALNTILFLSDSDMRQAINILQSTLYSKEVNENVILKITGQPSPKLIESIIILLLKNKVEEALSKFDCIWSDGYDPQDLLVSFFRVAKNMDNYEILKCISKYQLRLFEGVGSKLQFYSLLRDISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTM7</accession>
    <name>L7JTM7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-dependent Oligopeptide Transporter (POT) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994075">
        <property type="protein sequence ID" value="ELQ74112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2975"/>
    <dbReference type="HOGENOM" id="CLU_631912_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTM7"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="434" mass="48283" checksum="392DFA87954FBDA9" modified="2013-03-06" version="1" fragment="single">MQKLTLFLIISTEFCERFCYYGLRALLFPFLHNNLSYTVSAAKGLAHAFFFLSFFFAVIFGFVSDVFIRHYTTIVALSIVYVLGTAMLVLSAYTSSILCFVSGLVLVAMGTGGIKPCISVFGGDQAAKNSNFFSLFYFSINCGAMVSILTLPIIANTNYTVAFSVPFVLISTAVVLFVSGTRMYTMRAPDPKTYRELKAFLFGKNTRAFYVGHGYGFCPDLCVVAGANEEDGNFNEVVGVHKMGDVVEMNGGSFNEVVGVHRGDMHGMDGGDRRVRHPFSDREXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQKGCIGDQQPLLSLHTSLYIRRHERNKRILSSINASPFYTRRRVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTW2</accession>
    <name>L7JTW2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2905"/>
    <dbReference type="HOGENOM" id="CLU_2905766_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTW2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7096" checksum="BF7E0EA9054F386C" modified="2013-03-06" version="1">MDTYQNDNLVLLANMALISNFEANKSFVSNKHEFELQKSYNIETPSLKSQCNTVTNESKKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTW4</accession>
    <name>L7JTW4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2591</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTW4"/>
    <dbReference type="FunCoup" id="L7JTW4">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2591"/>
    <dbReference type="HOGENOM" id="CLU_063953_2_0_1"/>
    <dbReference type="InParanoid" id="L7JTW4"/>
    <dbReference type="OMA" id="AYCEVHP"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="11"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="227" mass="26228" checksum="F49C09A6C33FB0BE" modified="2013-03-06" version="1" fragment="single">VPNKLTSHQQPMDPKLIAHGAEAKIYLMDDTIIKYRLPKSYRISEIDVNIRRKRTRTEMKVLERLAANQVSAPKLLKIDECSEQFDKQTTIYMTNVPGMNLKDVILCLEHSEGQPIHRIAFSIPVIFNKLGKLVRKVHACGVVHGDLTTANFILADDLIYVIDFGLSYFSTKEEDKAVDLYLLEKAVRTIHKDEYMDDFYDGYGINEQAQMRRRLNEVRKRGRKIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTY9</accession>
    <name>L7JTY9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2115"/>
    <dbReference type="HOGENOM" id="CLU_1442018_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTY9"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="188" mass="22637" checksum="6848DA4BA6ADE76A" modified="2013-03-06" version="1">MSKRKTLFCIVFLILLFLIPMYLLRRQRTVMCGLKNHHNVCYINAVLQSLFSCESFTTMLESIEPENGSVMYYIQNLWNDMKNNTLLNRLGLYRRLASMSNFLFKYDNKPGFTENFLEFITINLDEEKVKGIFLDEENFRKTKTSCFFSKNQHGMLSWYQKSMQTQTPIWIRFEILWKKTILHFPRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU25</accession>
    <name>L7JU25_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2464"/>
    <dbReference type="HOGENOM" id="CLU_3144007_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU25"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="51" mass="5698" checksum="0A3F4F1F137954B6" modified="2013-03-06" version="1">MVENPDTETVTSETVNSGTIGPEKKMKLLELKMKTEGIGDEKEKVMFVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU44</accession>
    <name>L7JU44_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Checkpoint 9-1-1 complex, RAD1 component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2045"/>
    <dbReference type="HOGENOM" id="CLU_1215530_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU44"/>
    <dbReference type="OMA" id="MIIKVRD"/>
    <dbReference type="OrthoDB" id="10285542at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26536" checksum="F36CBA52AF2A11B8" modified="2013-03-06" version="1">MIIKVRDIPFFKSIIRSMNNIEYITFRTAHNKLIISSALINIYHAEIDSTLLEFTEYQAMDFSVNANLLKKILKFFKTQLIIKMNSSLELCYESAKKNYDISVPFIKTIKSELNEMGEVETLFVVQPIDLNFLQNFKKTTYECADKLVVKQNVEGGAEEMVFEVDILRAGGVSFTCDNLWLGPTKSIRSFVENVVYTFDHSMLQVTFVFRRQKDCKFIVQIPKLYERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU56</accession>
    <name>L7JU56_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2811"/>
    <dbReference type="HOGENOM" id="CLU_1954068_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU56"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="129" mass="14549" checksum="3342353B249B4BD2" modified="2013-03-06" version="1" fragment="single">VNEAKENLLNQFSEPSKERHRNNVTSSDKGEKTAVAEHLTPSPVKNRSVNFDNTPETARNVLLNTPINVAPPIVHENGSNRQFRKIRERNANRPKEQILDNGADTAAKMSSFKSFGKRENEKKLTLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU58</accession>
    <name>L7JU58_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetate--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2222</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JH994016">
        <property type="protein sequence ID" value="ELQ74840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU58"/>
    <dbReference type="FunCoup" id="L7JU58">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2222"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="InParanoid" id="L7JU58"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="179"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="679"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="942"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="772"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="619"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115828" checksum="5638D967A10F588C" modified="2013-03-06" version="1">MNILICAFHFFNISCLFDPFMKDAIENELVNVNKDKNEGMAGEEGISISTGLTSDRTVEDSIGVVEDSIGVEGVDGKDVVDSTTTTDTTTTAATANTTGNTLDGNFNLPWNSNRYINTSLKEQYNALYNHSITNPTFFLEQAIDRLSWYKQPTKCTNNNLQSLEYFSDGTLNACYNAIDRHPPDRTALIYDNDDGTSVRYTYAQCKARVCVIAGALHALGVRMGDVVCVYMPMMDDTLFVALACARIGAVHNVVFGGYSKESVVVRIKDSGAKVLVSVVEGTRGVQRLNFYKVVEEIIKEGGVSTALIIDGDCRGKGGNGCRGRGERDGKGGNEEGRGGNDCEGSERDGNKDNGKDNGNDKGKDNGKDNDSNPIVNPTTDPITNITNPNVNSKNFAKINFLSKMNVNTDIPCTPVKAEHPLFILYTSGSTGKPKGIIHSTAGYLLYAHLTTQHCFNTSSTSVFCCTADLGWITGHTYVLYGPMCIGMVSVVVGGLPTYPDVYRMWRIVERYGVTHFYTAPTLLRLLRKLVKEEEGECVVEDENVKDGGVDREEGKGENVKDGGVDREEGKGENVDEIVKDAVKDDKNIFVKNIIKDNIIKDNIIKGKNIIKDIIRNDNDKRRDDKREDKKYNNDNKDNNDKKDNNKDDNKYNKDNTIHPNDNNYNNKNNDKKTNTKYTVPSLRNYKKTGKHKTTQYNLSSLQVLGSVGEPINKETYVWYSRTFNGRPVIDCYWQTETGGIVVCPVAYVDGEVAECAGRGFLGIRVFVIRKDNDGKDGGKGNEGRVVKDSEDKGNEGKGKDESKGKDGGRVVNNNEDHPNNNKDNKDHNNTKDTNKINGRLYSYWSDEIEEHFNREGLVLAQENELGLIVLYGSWPGMARTILNDHARFTSTYTKHGVYYTGDEGVFYRGRLFVRGRADDIINVSGHRISTAEVESVCSQYVHEDERVVEVAMVGAPDEITGLCIVLFVVGDVCEGRLRAFLKRRIGAIINPRRVYFVKDLPKTRTGKIMRRVLKGLVCGEDIGDLSTIANEECIEEIRRVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU68</accession>
    <name>L7JU68_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aminopeptidase of the M17 family</fullName>
            <ecNumber evidence="6">3.4.11.1</ecNumber>
            <ecNumber evidence="6">3.4.11.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="6"/>
    <dbReference type="EC" id="3.4.11.5" evidence="6"/>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU68"/>
    <dbReference type="FunCoup" id="L7JU68">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2211"/>
    <dbReference type="HOGENOM" id="CLU_013734_0_1_1"/>
    <dbReference type="InParanoid" id="L7JU68"/>
    <dbReference type="OMA" id="GRPCAML"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="350"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="500" mass="54563" checksum="2E7AC46AF78BC044" modified="2013-03-06" version="1">MSPLKMLLDWKRIYTNEQKDDKPFTMVFYEKKEENYTVLFSTVDSSFLALTKAGAKDDTRIDVCQKMVYCAVEAPTYGNIRKAAALALKEMKKYGVENVRIDCGEFKEAAADGVLLAGFKYDFTVTKKNCVPCITNADSFRARAQNLARFLSLTPANLMTPTLFTEYVKDVIAHLNLTISTQIYDSRAIAEMKMNLFLSVAKGSAEEPKLAVLTYLGRDGNAGDKSSLDTCKTLRPTSADSLRINIGEESKSDVQTIADASEYDVVMVGKGITFDSGGISLKPSKGMEEMKADMMGGAVVFASVVAAAQMKLRVNVKVIIPLCENLPSGHASKPGDVIIGRNGKSVEINNTDAEGRLILADALNLAEDFRTKAIVCVSTLTGACVIALGNEYYGVYTDDDGLFERIRTAGYAVEDKGWRMPLDKKYMQCMESNVADMKNAGYKAGSCTAAIFLKQFVTMNSFVHLDIAGMLGTEDTSLFAGNITGRPCAMLVEFLKGLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU80</accession>
    <name>L7JU80_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2515"/>
    <dbReference type="HOGENOM" id="CLU_082796_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU80"/>
    <dbReference type="OMA" id="PFNTNIK"/>
    <dbReference type="OrthoDB" id="2190993at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031515">
        <property type="entry name" value="DUF5095"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17016">
        <property type="entry name" value="DUF5095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="250" mass="29664" checksum="E039618CBAB7F8F2" modified="2013-03-06" version="1">MNGYQSDITNCPSDNPFRCTNVVKKQKINPSEKIRTNQFNDDVFIKQLVKRDTSRKVTPKKCSTMNIYRKVKIVSKNVLEGKRVEYFKFPFNTNIKKDDSDLYNLVYMEWLLAITSVYKNYKNKNEEFYVKFFDKMFIFSTALYCSSACKEILEQLEVEYLNEGSFLKVSGIDVALVYDYVINYEFKPKDKLPFILSKHKFTNSISYDSKFVENQLVRDRGVLKHYYVIEGYLYGHDFSEYFEEDVAVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUA3</accession>
    <name>L7JUA3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1987"/>
    <dbReference type="HOGENOM" id="CLU_004199_2_0_1"/>
    <dbReference type="InParanoid" id="L7JUA3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1518" mass="174430" checksum="447EE0408B4066A0" modified="2013-03-06" version="1">MNFLDQTSNILIRWILWFANESDDAVIDTILCDNLEDMNLENVFVNIFESKGNITLSEFKIADYDTNEDPLGICKSGKRKRLDDDSAMESKNDCTSTNETDKENDKCKYRMIHVPVAKSLFMKIVNLTVTSEVKFSDEELYNIIEHLLTFLKDKLPFLRVLAQLFLEDSELRNKLEAINSKYISRNDKKRLTKDVSFDIKFQNAIREVEYHFGLFVTDKHGNAAVVARNDDTCPLIHTDVCSLCYFFIPSFIRMDGYFLIYNHDILCEVYENLSSDFDLTVDVDFSDVFYEVNKSYKDNKIPMQILTEELNSAFECKFFTLDCLKTCIFRLRGVQSNPKFDAIPDKQLNLYCQECIFNETLQLPSTLKMLSISNSKICCNWTLPDTLEDVVFKKVEVEKNCKLNIGRACKQINITDSIGMIFIPYIHEIFVPQFFLNWSVELVQNGDVVEKLTVSNAKFMNVIICVPRNIRAITLKDVSMDNEARLTLPREIKEVILEDFRGNVQFEDFVQNGPSTIHFDNGTFRSSVTKESDDIAEVVLSNVSLDQNIFFLLNPLNNYLSYIHSDPFVPLRFDKRIKSIILCNCIGDVYFESMPYFGQLALGTNVLYERSKESIKFNAFENTQLTKLVISNYYIVETVYLGLEIEEIKFENIVVADSKFVVINRNFKRLVLSNIKGCFKIPGIVSDNESDNNEIFEDPNFLEIVNVLENCYDITMKSLSFHRLTIDMNLRTACFHNVKVSDELLIISQQCENLHLHDVEGPVSTPNITSYKTIKLFFLEQFDCSSILTATVEDFEAKGVVFSKYPCITPATKKISLHSVTCDAVKNDSILLSEQCDDIYILCSSISMNISSIVKNISLNISIYVATRAICSLVTSCSQNITKLKLSGNFVDGIWRIERDVNFISLLNISAEKGSILQLNENLESIRIEFSQVNVDVSSIKNLRAITLVNVEAFVYIPFKYTPVSYLRFYGVAINFEINLGSNLNTFSITRSSLTIDHAIIINRNISHLSVSKFTGVLEMSGVAGLEKVTLTKEHEIYFDKWSKRNKEGLLCIVNYKFDSSVIFSDDVSTIRLKNVETAPHTKLILNHGCKCLKINSSNVDIDYSRATLLKKVILKAMSSLILRILLTKLSSVNTLVLEDMIIEDKIRLPDYLHTVVLRQVQIADKARFSFNKECSAVHLYYCSGMYDLVEIENLEILSLIPGLYERFKFVVTLPSLRSVRELNIAYNINEECFRYYLSKCINLTSLSVHSLNYSKRLIKYPPFHFGIEDIFDFSDSNNPRSVFELSKYKSNRDEWNWQYYILINLKMNILMHELLTLNLRNKLKYLNLAGCALNKENLNMLKECANLRVLVVDCAFLDNTFFETIPAQLETLEILDCKIFNGVRLDIKRLSCRSLQLLRTCKNLKHLVLEGTILKHEHIAECLPVSLESLKVTRFLKDSVEFAPATRKKIVIKRLVLLLDDVNCYPPVLIDTNPTKRQYYQLFDSLRNIIDFAALENLSLEASGQSVNIDKETYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUC5</accession>
    <name>L7JUC5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2156"/>
    <dbReference type="HOGENOM" id="CLU_1714607_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUC5"/>
    <dbReference type="OMA" id="YSIKLHA"/>
    <dbReference type="OrthoDB" id="10301031at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="153" mass="17899" checksum="4A04EA5A4B1D7279" modified="2013-03-06" version="1">MFFLIFAFYQTYARRGYNQDKVSNYELRGNNYGLNVQNHVQMHSYETQNASTIESISDTSTGYSIKLHARQGELDFRVEGNSLFITFSKENEHMEIKNQMRIDVINNDLHNFYAKEIHEDNDAYTVINLVFENPNGAEIKITKNFSEKANYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUD0</accession>
    <name>L7JUD0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate transport-inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2161"/>
    <dbReference type="HOGENOM" id="CLU_107279_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUD0"/>
    <dbReference type="OMA" id="YNLLECN"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="234" mass="27917" checksum="9FC148E5491CD890" modified="2013-03-06" version="1">MISKNINLDICLPRMSYIRGYLHTYDEAFLMVHAVRLGLIKPYRERLSLKERDDIRSGNIYIFIEDKTLMMRWTDGRTWSPSKILGSFLLYKEVPKNLTKNATMKNRRNKMERLKCTPLEKQLQQDKFLLHKKTISLSYGRETYHIIAYFQPIFDKRSILALPFFIVLDRALKSNHELLNNEYVRKLRKAKVSICKRYNLLECNKKNLTPNIDRKNLENEALKLLTNRFDINKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUE1</accession>
    <name>L7JUE1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ75039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="255" mass="28871" checksum="3D36ECC5D11CADFF" modified="2013-03-06" version="1">MYRNYVPVILFLFHLVVTMLFPNPKRLQINYFLQFFAHGMILSMMVVCILPNIFQNCTFVPIICTFLPFILLSLFERISTKNEDVSDAERSAFTKKLNHRQNVIFILAIFLHTFSDTICLADVPDTSMLKFGVGYGIQKSLESSLVAIFIYLTDIKMPIAYSIAYIYALCAPAGMLLGIYIRNHTSINDLNLKCGLTGVSFGLLFFNFVSELLSGGIQHQDILHEKYDRSSILAYGLGFFAMTVAGYSFIILSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUE9</accession>
    <name>L7JUE9_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">THOM_2029</name>
    </gene>
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        <name type="scientific">Trachipleistophora hominis</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75049.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2029"/>
    <dbReference type="HOGENOM" id="CLU_3417320_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUE9"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="26" mass="3379" checksum="B7DD6AE0F876F87F" modified="2013-03-06" version="1">MTHKYSPRLKVLNEDWSMKTFYRRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUL9</accession>
    <name>L7JUL9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_2057</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2057"/>
    <dbReference type="HOGENOM" id="CLU_025519_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUL9"/>
    <dbReference type="OMA" id="MNTYITI"/>
    <dbReference type="OrthoDB" id="2191741at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="17">
        <location>
            <begin position="277"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ELQ75015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="513" mass="58566" checksum="1C3365090B2CF470" modified="2013-03-06" version="1">MNTYITINSKYKTIGRLEIEIQPNDTEQNDVKPPNLNIFTNVLSNNKIFFLASLIVPLVHGSNTCRLKCLKGLYVLIRMYLNGCKNEEEFADVVSAVDKNILDGQADEKNAPFKTVNRLGVDESNKTGSNTDKSTGRNYKNVSTYRQPSKNLNNYELKDANFYKKLYVYYYFAVATYSSPLVLFQIKPQIKVVTNVAKEEKDAVLEHSAQAKMDTLRFTKTLDSFISGDVPRVLINNISKLRARILSFLNIKDSNLLEIKLNDAVPHLKFIHKNKLVVSFRGTESAEDILADVSCDYVEFLDGYAHRGILELAKKFLEEHENVINCYMKTMKLKKIVFVGHSLGGAIASLVSILLTIKNCTYPTSVMSFSSPPFLSYNLAKRFNSVRIFVLGSDVFPRLSYGSVLDFKYLTAAIGTADNLIKENDARLLRLFIKKVKKHLRRSELHPKLFLPGRIYHMRADRHYLYVSKVKRTSFDGIIVDADFFKDHMPSVFLSKIKNTVIRLLKNDERKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV46</accession>
    <name>L7JV46_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993969">
        <property type="protein sequence ID" value="ELQ75353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1702"/>
    <dbReference type="HOGENOM" id="CLU_1929074_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV46"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="131" mass="15027" checksum="6FB4FC14B1F90105" modified="2013-03-06" version="1">MSEKKGDANDTITSDNVSGYANRLKKHLDVPKYKLNDISIPRKKQVFDFKPRTEPDIISSSVVNISKKNTGLLILTVIIELFFLLFGIFVLVFDKAESVNIDRYDYENLHQSPDENVHNSLVYFGSYSYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV55</accession>
    <name>L7JV55_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1660"/>
    <dbReference type="HOGENOM" id="CLU_3279805_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV55"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4902" checksum="ECA26F178521C315" modified="2013-03-06" version="1">MEEDIESVQSIGYMIISTQIRSGRVYFLVVNLWQEYFRNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV73</accession>
    <name>L7JV73_TRAHO</name>
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            <fullName evidence="10">ATP-binding Cassette (ABC) Superfamily</fullName>
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            <ecNumber evidence="10">3.6.3.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="JH993971">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV73"/>
    <dbReference type="STRING" id="72359.L7JV73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1710"/>
    <dbReference type="HOGENOM" id="CLU_020421_1_1_1"/>
    <dbReference type="InParanoid" id="L7JV73"/>
    <dbReference type="OMA" id="RDINEWI"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="508" mass="57896" checksum="F6847C31337387C5" modified="2013-03-06" version="1">MKLEWLNVSVHARNKNKRSKDKYITLLNKACGCATQGLTAVMGPSGCGKTTLISTLAGRVPSSTKTSGCVLYNEKERNSSVWMNSVGFVDQDHAFFEGLTAYETVYYAARFKLKGQNVNIETKIAKLFEKLRIIDIMNCKMRILSGGERKRVMIAVELVSDPQIVFLDEPTSGLDNDVAFSIVELLKEVAQEGKIVIMSIHQPDDRLSLLLDKIILMSHGEIIATGTMQECQEYLMHNGYEKRDNTTFSSFAMEVLGNPSLKYNENGKDCKLEKLASSYRNQFVYDKKYQNTRVGSDFCMRCTPNLMDIGVLINRRMKLDVFRMKTFILYAIIIAIMIAIFSFGVLDNFVFNVSDKSADKFDDVLALIRVVNWFVLRLICNIEEVLIIIIAFTFNSVFNSEQRNIRREISAYSYTIVSYHLSVLIFELIYHLPLITCYLCATLYKYTPKQGIGFVIGCQLLRYWVIVNFGFLLISIFSGYKASIFFSHCRDVILLRCTPSQRPKSYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVA2</accession>
    <name>L7JVA2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molecular chaperone (DnaJ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVA2"/>
    <dbReference type="STRING" id="72359.L7JVA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2079"/>
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    <dbReference type="InParanoid" id="L7JVA2"/>
    <dbReference type="OMA" id="MGINIWR"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="74" mass="8551" checksum="C63A291A083C1F55" modified="2013-03-06" version="1">MLKRHIQKNEGFKPRMSLEEAHSILNTPSKRYIDISTAHKNLLMINHPDMGGSPFLAAKINEAKDLLMKKYRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVE6</accession>
    <name>L7JVE6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1766"/>
    <dbReference type="HOGENOM" id="CLU_2484916_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVE6"/>
    <dbReference type="OMA" id="IHTHINE"/>
    <dbReference type="OrthoDB" id="10353021at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="87" mass="10401" checksum="33F80AF936D671A6" modified="2013-03-06" version="1">MQRFTYPSMDDQQGWPTLPDYKELTQPEIPKEFVLFGIKFRMVDNVPQPEEEYEDLDITKMKELINESISSFKNLLKTGNRSHFREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVF5</accession>
    <name>L7JVF5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993955">
        <property type="protein sequence ID" value="ELQ75468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1583"/>
    <dbReference type="HOGENOM" id="CLU_189354_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVF5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="10309" checksum="68B05F0B2669860A" modified="2013-03-06" version="1">MEEFLGILLGRRCHESYDLCVKLVVEVTEYLARVVRELAVLYELVTDFLHEPNQMPAVVASFTDQKNVHVVTIRINKLIIVRKLISNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVI5</accession>
    <name>L7JVI5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1753"/>
    <dbReference type="HOGENOM" id="CLU_175004_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVI5"/>
    <dbReference type="OMA" id="LHECGQD"/>
    <dbReference type="OrthoDB" id="2193863at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11716" checksum="8D92BEE2A8AA3316" modified="2013-03-06" version="1">MSAEKIENIYPLAALLLHECGQDITKEGMKGIFDYVKAECQPKLAELYSVDKERMEGIYSMLMQAPAAASEAVVTDGAAKKEEAKPKEEAAPAATEDVDLFGDDDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVL1</accession>
    <name>L7JVL1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993994">
        <property type="protein sequence ID" value="ELQ75081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVL1"/>
    <dbReference type="STRING" id="72359.L7JVL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1977"/>
    <dbReference type="HOGENOM" id="CLU_915827_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVL1"/>
    <dbReference type="OMA" id="DRAQHTG"/>
    <dbReference type="OrthoDB" id="2195805at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="304" mass="34364" checksum="E65E37F17B0E1464" modified="2013-03-06" version="1">MRTNPADEKNKFFEAACRDEYNYYVKNMHTKPTSEAISFPSGWFGPKSTRKPSISYANDSVYEMFCLMSQGKRVAANTAANGKCIGGGFTTMWKYRKGKGSQEEGVMALLSGHLTSLLQFAQRDSKGRLLRIDNDSNQGRFNYIKNTLARNIILSKNLHTRIRMDLLDDYKRDRRGCKFFADYVAYRYSLDKSVLSHDTSYTIDIYSIAALDRRGLSRSITITRYNQLGTDTYDQISTMLKSAKSRNIYSVVITVPGSGVFSNIGYNSNAKKDTTYLDTVEEAVIAAIEKHGYGLEEIIICGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVS7</accession>
    <name>L7JVS7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993986">
        <property type="protein sequence ID" value="ELQ75141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1926"/>
    <dbReference type="HOGENOM" id="CLU_3002300_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVS7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6555" checksum="4DF5218BED5B3A84" modified="2013-03-06" version="1" fragment="single">VSESVFYLDILKRLILGENDEKVVEKRNFNQIGTISGKSDYSILNKTHTYPSESQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVW9</accession>
    <name>L7JVW9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polypeptide release factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVW9"/>
    <dbReference type="FunCoup" id="L7JVW9">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1601"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="InParanoid" id="L7JVW9"/>
    <dbReference type="OMA" id="ARFDECT"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="7"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="483" mass="53782" checksum="4393DB66468DBCD8" modified="2013-03-06" version="1">MPMSHTKPTISVVFIGHVDAGKSTLSGRILLSLNLVDPRLLEKYKEESRSLNRESWYLSWLTDTSPAEREKGKTLETCSTILELPHNRVNLLDTPGHKLYLTDMIRGANQADVAVLVISARKGEFEAGFERSGQTREHVILAKAGGVRHCICVINKMDERGFSARCFKEIVGKLDVFLRRIFKEVVYVPVSGYEGVNVLYDGEFKGMEGRLDGLGVRMDEVEGGVTTNLTNDSLSTNLTNNLTNGTNNNSNTDTTNGTNNNTTINNGAYNITGSNYNEINEHDPKWYRGDSLLGLLNKIRIERPQDSTMLTILDKTRNTLQVKVESGTIRKNDELFALPGDYKVCIGAVHDDEDVEIEDAHAGDIVKIRVNTDMLEIGNVLACRVHRCTDTFTCQLNVLECKGVLSVGYRAVLHLKMNSVVVKVLGLQVKKGDKVYKAEYVRKGEKVLGKVRIDRKAYVKEGDCFAIRDEDITVAIGVVRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVZ0</accession>
    <name>L7JVZ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative E3 ubiquitin ligase</fullName>
            <ecNumber evidence="10">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1457</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.2.19" evidence="10"/>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVZ0"/>
    <dbReference type="FunCoup" id="L7JVZ0">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1457"/>
    <dbReference type="HOGENOM" id="CLU_1160858_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVZ0"/>
    <dbReference type="OMA" id="SITMHNI"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="238" mass="27293" checksum="DBB9C13AD78BF4FF" modified="2013-03-06" version="1">MSSFIHYRFVSSTNAQKLTFEGASIPLWELRTEIINMERMTAKDFDLLFFIDDNQLTNESTPVYRNTTVIVKRIPAWMSKTTIEPKKQSKYVPKLPPNYVCFRCGQKGHFIQHCPTNDDKNYDLLRIRKATGIPKDFLKPVKEKEGTSLLVTQEGSYVQAQPQIHMFKVHGQINVTSDKLVCKYCTSLMNEPVMTTCGHTFCKNCVIFSDCVVCGAKVGKITERDDLKQEIEQYVENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVZ7</accession>
    <name>L7JVZ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor RNPS1, SR protein superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVZ7"/>
    <dbReference type="STRING" id="72359.L7JVZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1529"/>
    <dbReference type="HOGENOM" id="CLU_842508_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVZ7"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="262"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="344" mass="39150" checksum="B81BF702EF035B10" modified="2013-03-06" version="1" fragment="single">VLLMWMCYYPHMKIKVEIDDENKRMRKEGKDVHEVDVVREGVIDEGNDGKGENESMKNVINEENIVEKKNDSEKECNEGTGFDEERNYSEKECDEEKKNINDNEMENISRETMDMTGSNELNGKNEICKNRMDGVKNDGVIGEETEGIIEEEGVDDGLSVKSETKEREIMREGEQNDEDLLIQRENDGDKEKKVNNDEVNSAKGGNNVNINDSKESNTVSNAQQGMQSAAGKINDMKEDNDLERLQRMQDQFLQKDEPVTANSVIVRNLDHTITKQVLIKHLHACGTIKSVEIPQARKSGQPTKNYAFVEFMNRSGVNIAMSLNNKLVINGRRLSISRKKVFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW21</accession>
    <name>L7JW21_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1849"/>
    <dbReference type="HOGENOM" id="CLU_1455368_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW21"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="186" mass="21057" checksum="2DC77CE06508D684" modified="2013-03-06" version="1">MENTTTLLSESYTQLVNTSAVPANEQVQYIQSEIASFFETNFFSVLIFIPYFILGFLCFGIAHRFFNYITTKYINFRKPASASYSSPSALNENVINDSLDSEHIFISRAIGPCNHSTMENGLLVESLQNNNETNENENRDPPLYTADAQCFEQINQLPLFKIVTLPDYDEAAYPQQPPPPYSPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW64</accession>
    <name>L7JW64_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1498"/>
    <dbReference type="HOGENOM" id="CLU_2460926_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW64"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="10229" checksum="9ECC65741C967590" modified="2013-03-06" version="1" fragment="single">VLHCNDSTIEVKNKLPSILTALYIQNSYIEGVLESNHRLRVIRLYNIAAEHKLAVFVNERCTTIEITNVAGQVSIPFVNKYREIFQIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW81</accession>
    <name>L7JW81_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1749"/>
    <dbReference type="HOGENOM" id="CLU_1497328_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW81"/>
    <dbReference type="OMA" id="MFNRYKL"/>
    <dbReference type="OrthoDB" id="2194228at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="21579" checksum="EF0DD7DFB96C8CA7" modified="2013-03-06" version="1" fragment="single">VMFNRYKLKELKRTREERNDKSKAIKLNTPCTRDESDKVVHMLKNSHLLLNAYNKILNNDRLLNDNIYRLAIPIFGNLISSKKDRVIVKSIECIKKICESPNFLAVKAISYDYFKSLFYLDRFPRKLLRCFLEHYSDLAEKYDEEFWKAFKEKMAISTYNKKVMVKRNLNESVYLLNGGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW99</accession>
    <name>L7JW99_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1712"/>
    <dbReference type="HOGENOM" id="CLU_2795742_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW99"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="68" mass="8158" checksum="90BDF779ABE3455D" modified="2013-03-06" version="1">MKEYENTMEDKKLLFKFNVLFAHFVNRRRRLNDIILKINNNIAQIILRAESSKYYLKKAVRIVKGGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWC3</accession>
    <name>L7JWC3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small nuclear ribonucleoprotein (SnRNP) SMF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWC3"/>
    <dbReference type="FunCoup" id="L7JWC3">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1737"/>
    <dbReference type="HOGENOM" id="CLU_076902_12_2_1"/>
    <dbReference type="InParanoid" id="L7JWC3"/>
    <dbReference type="OMA" id="GYMNVQL"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="113" mass="13068" checksum="05A276E8E97D2EA6" modified="2013-03-06" version="1">MSFTTIFPPSRKLILLHCLNKNLGPLIEPPHMQETTKENPKQFLKSRLGKRIRISLKWNVDYEGTLDGFDDNFNIEVSSVSEFVESRMVGKLKKMVIRCNNIKSMEDVPSNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWE4</accession>
    <name>L7JWE4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Heme NO binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWE4"/>
    <dbReference type="STRING" id="72359.L7JWE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1249"/>
    <dbReference type="HOGENOM" id="CLU_1723710_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWE4"/>
    <dbReference type="OMA" id="DDFILHT"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="18354" checksum="C92F30E4D97370F9" modified="2013-03-06" version="1">MCLRHPCIQMDEKISSEFFGLLFNLCIKSTTSPYSLGESIGNRLADDFILHTGISRKLSIDEFVHTVQNDFFPHYFSYSPKRRGNVLLFKHFNVFAHMRDAKGALNVFAGILNVIGACLCDDISVKAEDGNVNERGIVFNDRKNEKMKFYNVEMQNDDTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWK1</accession>
    <name>L7JWK1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1630"/>
    <dbReference type="HOGENOM" id="CLU_2856132_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWK1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7772" checksum="B557E9F7C64E7FA1" modified="2013-03-06" version="1" fragment="single">VRYSYLKLFFNLNKASERENDSLEDQQKERWLTNSKVDHGERPDQMNIFIEKYGLVITVQNDYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWQ2</accession>
    <name>L7JWQ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molecular chaperone (DnaJ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993912">
        <property type="protein sequence ID" value="ELQ75859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWQ2"/>
    <dbReference type="FunCoup" id="L7JWQ2">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1173"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWQ2"/>
    <dbReference type="OMA" id="SSKYVYH"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="296" mass="33719" checksum="5267D1225715D167" modified="2013-03-06" version="1">MDDPYKTLNISRTATQSEIKKAYQKHILRCHPDRVKGGPEAKKKAEEQFKKIQSAYEILSDEQKRKEYDTFGRVGSQGAQGVHDFSQFFTDGQFGNIFDFGNFRGTTSFRTEDFQGAFGDVFGDAFGRKRRATQEVKVRLSLDELYNGITKKVCVNVRRDNARVAEFNVDVKPWYKSGTKFTYEGAGDATRTGYKDVVITVEEIRNPFFTRSGDDLEYVFRTGLKELVTMNKNVYLPGGRVYNLRWADVKVIGDFFVVKGMGMRRKKGGHGDLKVKVIVDVDVGTESMDRISRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWQ9</accession>
    <name>L7JWQ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40/YVTN repeat-like domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993903">
        <property type="protein sequence ID" value="ELQ75918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1116"/>
    <dbReference type="HOGENOM" id="CLU_542036_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWQ9"/>
    <dbReference type="OMA" id="ERYVHDG"/>
    <dbReference type="OrthoDB" id="10480908at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="503" mass="55408" checksum="4D31832E2FF9AA33" modified="2013-03-06" version="1">MNEQLKHGVIRNIRLKDCMPLIAFTDDEMVVAYGGMIEINRRKNTEREDFEIIDNKGRSTKNERGNKTGEVENDKEGDTERKDKNERENTAQTISNEQTVTNDENSIKSNASHESIHTSDTPVSIPGAEHKNTVIPRTATLSDQYVPIRTHRVNDVITAIASAPTGVYYGTLSGSVLAHTRTYRMTRAPVLSVKVRDGLVVCADSDGVLGVCRLDGRDGRVYKVFEGGCYEVEPLEGGYVCGSENGEVVFVSDEEREGGDDEGEGGNDNDKNNDNDKNNDKSNSRDKSSDKGKGNGRDKDNVNDNNVNTTLNDINPALNNNINSPALKNVNNHQNFNNTVKTPNTVKLLYKHKLSVNHLTATLSHITSSSADHTTTITSTQSSTSHTYNDHTASVNAHLHHNRLYTVSTDTQMLVYDNERLVERYVHDGPVYAMGYGEWYGLIGTGTLGKCVYFYDGRVGLVDRVCVGMGVREMVFGGWVVGYCGVEGGVGAVDVRMMYKGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWT0</accession>
    <name>L7JWT0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWT0"/>
    <dbReference type="FunCoup" id="L7JWT0">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1564"/>
    <dbReference type="HOGENOM" id="CLU_055156_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWT0"/>
    <dbReference type="OMA" id="SYYVDAQ"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="248" mass="29174" checksum="7AB7F5C5A7251528" modified="2013-03-06" version="1">MEPLEMSTCLKDLPPYSYTSKEEYSHKLQTLKETQERLYQERVQKNKEYALKRVMELTAEYKKTELDTQMKEKQAAMTNQLYVSGDPQFFVVILIRSMIRMPAKLKKICELFRLKKINTLVMVRNNESNRRMLQKLRNFVAYGFIDINLLRTLVYKRGLGRIDNKAVNLTNENIEDAFDGELRCIEELIYHLHYGTEYFKVVNNFLMPFGLNCPKGGFRGKKNRDYVEGGCAGNWYSEIGTLVKRMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWU1</accession>
    <name>L7JWU1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993950">
        <property type="protein sequence ID" value="ELQ75531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1515"/>
    <dbReference type="HOGENOM" id="CLU_1504499_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWU1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="179" mass="20086" checksum="177F52B19874F2AF" modified="2013-03-06" version="1">MPDRSLHVCDQFIYVIKNGECTVYSHNLHKMKTIQNVRSIHNDLIYSTPSHLIHTESKYKIPDITDIRVHDDLIITTSNQTLSVYVRLNGTLYQKASVPKFGTLVHTDKDTIVMVDGNYEYEMAVVRECAVSDGVLLFSDGRDVVGSDYGRASVPLPFYMWRVGGVEAFCGMEGTGCMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWW2</accession>
    <name>L7JWW2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="7">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="7"/>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWW2"/>
    <dbReference type="STRING" id="72359.L7JWW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1830"/>
    <dbReference type="HOGENOM" id="CLU_1277944_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWW2"/>
    <dbReference type="OMA" id="CEFEESF"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipase D-like" evidence="8">
        <location>
            <begin position="70"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="21423" checksum="5D63D6EC1A7586D7" modified="2013-03-06" version="1" fragment="single">VIPYCEFEESFVIEKVFGHKFSEYYISTAYINFPETYLKHIRTKHTTIISPDSSCNTFFGSSFLDKLVCKLYDYYTIKTENILEKADLRTFYKKKASFHFKGIWAFAGDFAITVIGSSNFNERSYRKDKELNFVLVTKDEQLIKQFKQEIKYLKRHSVKVDGDNQVSIFVKLVGYMMKYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX01</accession>
    <name>L7JX01_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1063"/>
    <dbReference type="HOGENOM" id="CLU_736052_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX01"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="376" mass="42112" checksum="BECFC175B15A8F02" modified="2013-03-06" version="1">MHKIRKNMESRRNGEECEWSADSSGKTKETHGCGAECGEGSGRESSWERCDGEEIGSKEECVESEGGDGHVDGDSGEVRIDGVVRIDEVVDEADDGVVDGRVNSRVNSRVDEVDDGRVNSRVNSTANNMVNRIIDEEVVKRDCMKEVSLEMVNGMIVNGEVMKEEIINEEVMKEENENMNNTRKEEKNKNEEKENEETTNKEDEETEKKDVGMSNGCKDEISVFNYENGEDSNDHSSNHENSSNDHSTRGNDREXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX04</accession>
    <name>L7JX04_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993977">
        <property type="protein sequence ID" value="ELQ75257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1805"/>
    <dbReference type="HOGENOM" id="CLU_1972017_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX04"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="127" mass="14355" checksum="1C30DE92BF84760C" modified="2013-03-06" version="1">MKVLKFDVIGLKKTKLDFITDILQRSMSIHAFKESLQQLKMFKSVDVESYKDAGIRLSVEEEKCKISAGTNVDFSRRFMPYIQLKLPNLLGRGESLNFLVSAVKSLQVNLSIPLLNKNGFLISSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX42</accession>
    <name>L7JX42_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1744"/>
    <dbReference type="HOGENOM" id="CLU_1120785_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX42"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="248" mass="28853" checksum="4C90731FF2607B54" modified="2013-03-06" version="1">MQDRSIEYHLRESLFYETSSAVVNTILETILNVFVAQTIRNIEFESIQLSKHNYKILTNLKTLIVLDLGTKSITDKLFGCLPPNLKLLNIAGLKKYEKSEGIKYNLIEVQRIAELSNLKVFIIDADLIFKICALSFIPSSVEVLKIYFEVIPEKLPVLPEPLLHLRELYIECNNPYEDHYNRGMNITHTKPFIDYLQKCIDFESLEQFVFVSPYTLIKIDPLTLEFIETRSGKFYEHFGPIHDEVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX43</accession>
    <name>L7JX43_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993910">
        <property type="protein sequence ID" value="ELQ75875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1171"/>
    <dbReference type="HOGENOM" id="CLU_520906_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX43"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="523" mass="61111" checksum="1E010335AF5CEEFA" modified="2013-03-06" version="1">MYDSIVVIPSTCQKLTLYQSVGLFDLSGLGGVREVYQNDARYSNIDLSLDFEDSSNVLVLSYLHVHRNTVIQNKFKKINFTTVRSTIKITIPVTETTEYINVSQSMGYFNIVGLVNIELNFEGFNTIFCMKQGDDLLITLHLIDCEVENRIEVKFKKYRMELYKVHFKNVIYCSENQLYSDLAISHCTGTLDLSGKFFNRMEVAFVITGVKKLFLKGPIYLNYLILSNIPKEVDYLQEFLAQFHSVKYLKIECSFIGGPYQNLEHYFTKEKRATLSRLLQENSDPNDNNRLRIEESILNQEADRFLAVIFEEWTVMARLKRLFYYNVHMSNRNYWYVQKLPQLQILSASMENLTHYSFLYPLISLRSLDLSGSTVDNVELPADAPIYDALMNLVNLKVLIIEGKYYENPAYLFCLPQSLEVLMISYYEINFGTEIPEAPMIKLQLLYITLLDTNLDEWQSFNEPIRTFINGLLRYIDRMYLMCLVVEHNAKLYQVDPLGLSIVYQWDNVFDLGFFTDQWIQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX65</accession>
    <name>L7JX65_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0973"/>
    <dbReference type="HOGENOM" id="CLU_3279803_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX65"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4815" checksum="3558003A3FBD3E33" modified="2013-03-06" version="1">MKNDDRVPCHKDEYRKVIILALNFPYFVMGIKIASLSHFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXC1</accession>
    <name>L7JXC1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCT-eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXC1"/>
    <dbReference type="STRING" id="72359.L7JXC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1695"/>
    <dbReference type="HOGENOM" id="CLU_008891_0_1_1"/>
    <dbReference type="InParanoid" id="L7JXC1"/>
    <dbReference type="OMA" id="ENCTARI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="267" mass="29612" checksum="688FB3C15CAD02DE" modified="2013-03-06" version="1" fragment="single">VRLKSVEDYQAIVDAEWKLIRDKLDKIIDTGANVVLSSLPVGDYATQYFARKKIFCAGRVAKEDLFRVVNACGGKIYNSTNFLNTCGTCTLFEEKQVGKLRYNYFSGGTKKAYTLIIRGPGEDVLNEVERSVNDAVMVVKRTLRNNSVVTGGGSTEMELSRYIREEGKNIAMKSALVYIAVAKAFEVIPYQLAKNFGQDAIEIIQQLRYEHSNDKSHSGVNIKKGTSDMLEDGVLEPLLIKTNMVKASFNAVSALLMVDTTIVSKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXD7</accession>
    <name>L7JXD7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993893">
        <property type="protein sequence ID" value="ELQ75980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1055"/>
    <dbReference type="HOGENOM" id="CLU_2639855_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXD7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="77" mass="9317" checksum="E71A4C610C45EF36" modified="2013-03-06" version="1">MLVSEVNEYETRLLVYIDLRNINFLFGPRYLIIHSRFLMNNHEYLNKLYSNDLKNKNKLIVDVDFCIASKYKRNIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXF9</accession>
    <name>L7JXF9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1631"/>
    <dbReference type="HOGENOM" id="CLU_2265750_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXF9"/>
    <dbReference type="OMA" id="PKEDMNQ"/>
    <dbReference type="OrthoDB" id="10253286at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="103" mass="11901" checksum="7FA37F6ACF72A254" modified="2013-03-06" version="1">MQMLPKEDMNQLVKIIEEGGEVPINVSINELSKDGEVYSIDLLSCTNIKDNRKIEFKMIETDEITAIDNNIVFEDFIKVIYIDDYVERIKGDDGCFTGWFKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXG6</accession>
    <name>L7JXG6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.11.9" evidence="6"/>
    <dbReference type="EMBL" id="JH993872">
        <property type="protein sequence ID" value="ELQ76124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXG6"/>
    <dbReference type="FunCoup" id="L7JXG6">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0905"/>
    <dbReference type="HOGENOM" id="CLU_011781_2_4_1"/>
    <dbReference type="InParanoid" id="L7JXG6"/>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="391"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="5">
        <location>
            <begin position="626"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="687" mass="78759" checksum="325D719A4FB86B05" modified="2013-03-06" version="1">MTFRTTLNTCNISCMIIFLTDNHMNEYIHKSDNIVTPLTGFTGSTATVLITSDHNFLYTDGRYFIQAEKELKDNFVLKKIDVDQSYLEYIRDNVVGNIGMDVNRVDIKTYKMIKNVLAEREIIHVRNELFCEYGERTFNDVIDLEVVKMKDCIWLFEHKHAKKLVLDILKERDASEPIASILEKSCRLVSTEKQNNVDQCKRVSNAKDDSSGGLLKKWHSPENIRAILENSPHESQNEKQIIDDILNSSIAGISSDDKIALLRHSLDDSECMIISLMDEIAYLLNLRGTDIPYNLLFFSYMFVDKKNAVLFTNSKNVKRNVCIRSYDEFECFLDAFYQNTGDIKLNDYTRVYVSLDVNAGICIKLGCKAVVSDFIQKLKSVKNTNEIVGIIQANIIDGIALTRLFVWIKHAFQKDKITEIQISKKLLEIKRELCTSFANKMKADVNNHGSCIEDSITNKYLSRGCFVSESFESIVGVGSNAAIIHYKGGDINVENNNVLLMDSGSQFLFGTTDITRTLFLGKSPSKFREYFTRVLKGQITSKTLIAPQDRFLQMVCNVARLYLWNIKCDYRHGTSHGVGHSSLVHESLPFRSIVPHQMFSVEPGVYLENEFGVRIEDVVMAIGDEYLNIVDLSYVPLQRNLIVKKMLLKSEAKYLNGYNDRVRKVLSPFLNKEERKWVKRQTRRIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXI2</accession>
    <name>L7JXI2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3">5.1.99.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3"/>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXI2"/>
    <dbReference type="FunCoup" id="L7JXI2">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0900"/>
    <dbReference type="HOGENOM" id="CLU_024853_3_2_1"/>
    <dbReference type="InParanoid" id="L7JXI2"/>
    <dbReference type="OMA" id="SMFRGRY"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="18777" checksum="96FB6038D82EC496" modified="2013-03-06" version="1">MKKRASNILVVCGPGNNGSDGLVIARYLKLSGYDVLVFYKKLKHQNLVNIAKSVGVAFTTNWPDDILHYECVIDAMFGFSFKPPLREPFSSIVSCISGHNNVISIDVPSGYEINNEHNNHSFIPKHVVCFVAPKICTKTCKSVFITRCFVPRHIYDDDNDYSKFKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXN7</accession>
    <name>L7JXN7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1565"/>
    <dbReference type="HOGENOM" id="CLU_2016816_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXN7"/>
    <dbReference type="OMA" id="GYEHYIC"/>
    <dbReference type="OrthoDB" id="10472735at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="123" mass="15138" checksum="DF4E264E6F082B5E" modified="2013-03-06" version="1">MYDVPPTIKEIRRAKRQKNLQKQRLIRRHVLLDIPLPPKKKTLLPKKNFLIIIRNPKFRKCKSGRRYRNYIFMDGDKRTLKDMKKNYGVNVVHYEERRRMFNGFKEIEELEDELEGYEHYICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXT9</accession>
    <name>L7JXT9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor E2F/dimerization partner (TDP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXT9"/>
    <dbReference type="STRING" id="72359.L7JXT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0891"/>
    <dbReference type="HOGENOM" id="CLU_032091_4_1_1"/>
    <dbReference type="InParanoid" id="L7JXT9"/>
    <dbReference type="OMA" id="XPSKIRI"/>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="6">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="219" mass="25223" checksum="F73156F8FF8D37F9" modified="2013-03-06" version="1">MPMAPVSSERLSSSRLENSLFVLTKKFFIYLKQVYPRAIDTNDLSHYLCVSKRRVYDITNILEGLGLLRKRSVNSLEWIGGDFNNFIAAEGEERVGGEVIDDLEKENVNNLFKNRYDSGSSAIDQLNKEEKELDQKIFIMNNKIQNMLQLDSSIKNAYVTHKDLLGLPSLQNKLIFAVKAPQETFLENKDTKNEYMMEFNANSDQIDVFYVSSENDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXV8</accession>
    <name>L7JXV8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="2">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="2"/>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXV8"/>
    <dbReference type="STRING" id="72359.L7JXV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1450"/>
    <dbReference type="HOGENOM" id="CLU_044879_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXV8"/>
    <dbReference type="OMA" id="LCKSQIY"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1 2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="4">
        <location>
            <begin position="237"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="469" mass="53990" checksum="8388DAB3B89D3BD3" modified="2013-03-06" version="1">MNIRNHLITKCKKLLNFSKQHNFKTRHVLNKILSQLEEKDEITWEEFINLKYVGPKTLPKFAIPNKNQTADAPNETANNKNALGDGDTKGTASKSSSNNHKVHRHQEKTVKDETTDNSKTGANRSKNLGIDGITKKTYNKIEDFEYVPGFNTIAYNILKILSSNDGLCKSQIYLSSKFLEDEISGLHIWCALKTLLQKNLIQKENKRYFLTYKGTSLCVIMFDKTEKVLDRETNEVVLLVDSREMKSKNDRGYFERKLPGSRTLNLVVGDFLWIKGEYVVNTIIERKKGSDFVSSLYDGRFVEQKNRLKNTGLKSCVYLIEGLRSRDNFIESAIFKTKLEGFTVIETRDIEETVLFVRNLDDKIRKYDASNHETCEFASVSSITFYNFSNQSLKTKDFSQQYLLYLSFLSIKGISHLKAKFLCNYFQTFDNLVNECKDVDKLKSILSEMRVNGQLLGKNVVENILHLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXY0</accession>
    <name>L7JXY0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993904">
        <property type="protein sequence ID" value="ELQ75916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1124"/>
    <dbReference type="HOGENOM" id="CLU_505461_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXY0"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="539" mass="60983" checksum="1615CB30B7217045" modified="2013-03-06" version="1">MKEEYYTLDLSKNNLTEIPITYKRVHWLILSNNNLINTKNIQYYRDVTRLALNDNYLIKLESAINALVNLNWLDLTRNRLSELPFINLKNLNGLGLSENNFDKIPSCVFNLVNLRKFGFFSNRLKVISPLIGNLINLTKLDLSNNYIKTLPKELFSLKKLTWLNLSNNQIESVEGINNLVHLEELGLGNNQIEEIDIALTSLKILPLFNNKIRKVRIRMTRIEKLDFSDNLLEYFDWRVLECKKLKYLNLKNNRIKEIRLEGMESTGYCYGYVRYSNVGGDGGRYEEYSRSTATSEGRGCSGVGECVFGTGYGGWTRSRTVSGSREYVKGWNKSRADYRSEVSSKGGFSDYRNGTNVGNGMNVGNGSNGGVRNDCRNGFNGSRTVGSRGGKNNGDRNTGDKNNFSNNNRNNFSNGGRNNSYNSNRNNSYSSNRNNLTSTNKGSKNNLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTTMEIILTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY36</accession>
    <name>L7JY36_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0816"/>
    <dbReference type="HOGENOM" id="CLU_3160279_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY36"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5580" checksum="4CD469628E38D8F3" modified="2013-03-06" version="1">MKNLIESKNGQIFVIEGTNHFNMGKKDEFFSILNDNVYNEMVISNIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY39</accession>
    <name>L7JY39_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0661"/>
    <dbReference type="HOGENOM" id="CLU_1147873_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY39"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="242" mass="26066" checksum="0173708385716C53" modified="2013-03-06" version="1">MWFTRLQKTLKILISEYEPDKAMIRNKMYNEACVCILQRIDSNNKVVTNHVLLLNGVGQAHQRRNGIGQTGSSQQNAEREAINEFIPQTSGRNGLSEPDSLNGALVDVPMRNPEFSNKLQSAINVASSAINAVKNPVEDQQRYIHEQRNARNPEETNIRQESSVMVRPGAGSSIGIDPPEPAAVSNDHVNDSATNDTNNSGTGNNPTSSGNPTSPEGDVIGQPNGHGEGLEGDTPASTSTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY64</accession>
    <name>L7JY64_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin synthase sulfurylase</fullName>
            <ecNumber evidence="3">2.8.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0999</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0999"/>
    <dbReference type="HOGENOM" id="CLU_013325_1_0_1"/>
    <dbReference type="InParanoid" id="L7JY64"/>
    <dbReference type="OMA" id="IPDVGMD"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:adenylyltransferase activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:URM1 activating enzyme activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cell budding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cellular response to oxidative stress"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:invasive growth in response to glucose limitation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of pseudohyphal growth"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
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        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
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    </dbReference>
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        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RHOD"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
            <begin position="301"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ELQ76001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="386" mass="43905" checksum="20B2EB7627D6A3D4" modified="2013-03-06" version="1">MSSRIFYWNISTPMNASKEKKMKKKIFFESELSPSDTKRYLRQLILDDCTPENQKKLFRARILVVGLGGLGIPVCLYLVGSGVKHIGIADGDKIELTNLHRQVIYNEEDVGKSKVLVMKDKLLKMNAELTVKTHDEFVVKDNVEMVNEYDIIVDCSDNISTRYLLNDNTRDRQFVCASVLRWDGEIYLFSKNDACYRCLYPIPKSNPESCNDSGIVGGICGVVGSLLSVEIIKMVFFETKSKLLIYDGKGGEVKTVKLRERQSTCLACNKKAISTNITLNYKQLVRVDEKYKIPWNEYFENTGKYDLIDVRKKKMFVLAHVKGSRNIPMDSFNLNELTKKMPLIVCAKGSTAQAVARTLLDNNIECRVVKDGLVSFKRDIDPDFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY67</accession>
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        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">THOM_0806</name>
    </gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76245.1"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="176" mass="20480" checksum="FE9F70725A2110E6" modified="2013-03-06" version="1">MIIIGFSVCNIKDNMSEKCTNVKYLLLLLFGNFCNSVSCIFFDRKIKQKNVNYWEYMYTYTFLNLLISSTELVLEYSLSSYDFAAYLRNKEFYLNVVAQTLETFLIAYVSFQLTPLQRGLNHIVCAVSITILTNVFFETSPGIYQVLACIFTYAGLVMFELKSLKRIITRQNQERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY91</accession>
    <name>L7JY91_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1024</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76026.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
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        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
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        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
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        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="123" mass="14263" checksum="E420D879394E648F" modified="2013-03-06" version="1">MGKKMNDSLEDHSEEEIFSSQIKRKIIEETTKCLTKRRRNSVSVKKEVKVCGGKNAKNNSKFCKKCGKKLRLMGEFTCRCGGVFCAMHRFYDQHGCSFDYRKEAMAKLEKMNPKIVNDKITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYA4</accession>
    <name>L7JYA4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol 3-kinase VPS34, involved in signal transduction</fullName>
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            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.1.137" evidence="2"/>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYA4"/>
    <dbReference type="STRING" id="72359.L7JYA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0562"/>
    <dbReference type="HOGENOM" id="CLU_476658_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYA4"/>
    <dbReference type="OMA" id="CVINAPS"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="1">
        <location>
            <begin position="312"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="572" mass="68467" checksum="2AEEFD644AE7E956" modified="2013-03-06" version="1">MLILYEISIKTRYFNTTVMRITTVFGYKHTYFIYGFGTIYLFLDVSTHHLRYEIRNLNLEIQLNDTHILQNCITCGRVLQINRDLKDTHLFRSCCKQFLYKITTRAKSSPKFKTSSYYDPLTKKYRGWHSTITFRKSIHQLKYVWKNVKELMDDLRNIGKDKTNLQQFIFHRYNTKGYFRLLKGVTAITNAVLSGCTLVNSKYHLELFWSLRFLYKIDKISIKTAKFLYELMTKRNHRFSGNFNAELHHKVHQQILLYTRIKKFHKLCDFLKTRSQTKRMAFLLSGYYFTNKTCVINAPSFFNMNENIKEICVDDIWVYESYNFPIKISYRTKNERLNMLYKCDDNLSNDFFMLCVSEYVSYLLRLKIAKYKILLFTSHSGVIEMLDADTFSAVYRNKALNFSSLDCTHQNILLKTFAFCVLMAYLFGIGDRNDDNFLVTPKKQVLQIDYSYLLGDDPKPFKNSIVIPRMMQKILCNDELVFEKFMSYFTRYFMKIRSNNERLYIFFRFIAVHSFSNVDIIAIRRYFLEKIHLDKPKEEVINIIRKEIKKGMRSKLNKLYAMLNIFGKYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYC5</accession>
    <name>L7JYC5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYC5"/>
    <dbReference type="FunCoup" id="L7JYC5">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0580"/>
    <dbReference type="HOGENOM" id="CLU_005230_1_1_1"/>
    <dbReference type="InParanoid" id="L7JYC5"/>
    <dbReference type="OMA" id="FNARIFM"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="906" mass="103811" checksum="293E0E7B070140A6" modified="2013-03-06" version="1">MFLQSEKMRRISLYINKENVRRALYELGKLKLIQFIDLNTHLKNEHLPYNKEILHYEKLRSKINFLMGEIEAYELDVPCTEHVFDEDAVERHFNRLLELKAIRDGAQEQLTNLNENLFILEEMKEHDFSASSCLTGIIDNDKVLLLRRILESVLKNNLVVHVKTGRRTVFVIFTHGEEAFEKIKKICVSFNARIFMMKNEAERSVEEENAQDERAQDQKDEPEDENQTNILRVTALIQQYQHVYANNENSIRSELSTIAQHIYTWRYKTRQMLRILKTLNRLRESTAFIGEGYVPESKFAVFQSAVNAICDAHGRIAYEEQVRTGDNLEVSVLVTGDNTNRRESRMREREIRRMMDEGDDGENKGNKEGEYHEVVRGGVRVGEGRAGEGSSGDRVNEVRAGEGSGDRVDEVRAGDEDCRVVSEERTADEDKHCDKDRTGDKDEDDDSKEESVEESTRRRKERPNKMKNEDKKIKDRKIKQNNDNQRNSPKNSAQPLKSAPYKNDNSSLSNSMEDIRAAREQNEDHKMNEHEMPPTFFKTNIFTRPFQEMNDVYGVPSYREINPAPFTIVTFPFLFGAMFGDVGHGLILVLIAVAFIMRPGLARAHEMVEMVVNGRYMLLACGVASMYFGLLYSECFGVALPLFKFGGVTYFGVDPSWHEARNGMNLMNSLKMKMSVVIGTLHMGLGLGLAAFNTLLSGDTLLFYCKVLPRILSFACFAGYLSVLIVIKWIRPFKPSIINTIVLMYTDPFKAELFYPGQQYVQLFMLALFAMCMPWMMASYPLMLFVRHRRKNLSDVIIHFGIEAIEFNIGLISNISSYLRIWAVSLAHSQLTGIIHKYTMGSSSVLLRIVTAPVWLAATMVLMVALEGLSSSLHAMRLNWIEFNSKFYDGQGNAFEPLNFDEDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYD3</accession>
    <name>L7JYD3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Synaptobrevin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYD3"/>
    <dbReference type="FunCoup" id="L7JYD3">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0971"/>
    <dbReference type="HOGENOM" id="CLU_184655_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYD3"/>
    <dbReference type="OMA" id="EVEQKMW"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="90" mass="10693" checksum="F0C3297F12064228" modified="2013-03-06" version="1">MGDEITLKINKELLELQDQLKTNIKNEVDRTSKLKKLSKKTEGLEKRGQVFKKKAVEVEQKMWWKSVKYWIVIGVIIFVILLVIYKLFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYG7</accession>
    <name>L7JYG7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1238"/>
    <dbReference type="HOGENOM" id="CLU_639681_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYG7"/>
    <dbReference type="OMA" id="LMPENYD"/>
    <dbReference type="OrthoDB" id="10360901at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="423" mass="48206" checksum="016E68ADD7A83215" modified="2013-03-06" version="1">MITHCTITTNIFTLALNVYQLYVLLTKTYYYSFVMTPRMKACALMHGCYNLVAAAYSFGSLVMVCYDGLSFLRYLGEYVQMMVVLLVAEVGKEKRMKYDGDMKRGDWVKEGMKRGEWVKGLEGKGYFKEGLEGKNYLREGLEGINIREGMKRGDCFKGPEGENYLKEGLEGKDCFREGLEGKDYLREGLEGTNLKEDMKRSRRNENVIEQERLKKSLEQEINGEHELSHKNLEGQDHNEEERYDDILERAIAPYSTNGVEQLRTDRINDLHGVTTKPARKDARPSSGPPVVPLTMTITTSLLLCIASIYFRDMPTLHDVFFSALITCNLVVILVLNCVYRAGATNALCNVLLIIAELLSIFVQVKVLRKSIFYDLLSCVNVFAMVALFRSVDGALFDRPGTVPFYTALMPENYDEEFCKKVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYJ8</accession>
    <name>L7JYJ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein involved in meiotic recombination/predicted coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993840">
        <property type="protein sequence ID" value="ELQ76538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYJ8"/>
    <dbReference type="STRING" id="72359.L7JYJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0475"/>
    <dbReference type="HOGENOM" id="CLU_080628_3_1_1"/>
    <dbReference type="InParanoid" id="L7JYJ8"/>
    <dbReference type="OMA" id="VCYWAFP"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="2">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="187" mass="21642" checksum="2953C7B34920C122" modified="2013-03-06" version="1">MAKQTTKEQKKEIILSLFNPTTVYNLKELEKLSSKLGIRSNLVKDLVTELTNDNLITSDKIGISTYYWRIPPNNSTEYKRLTSQLHVKELEKQRLTQQEQQLKAERCDASRADMIDEYAALSKIGDVPFCLEHYRSLCDGVDVMRDDVNRITEDVFVLRRFVCDTYGMLVGDFDRNFGVGDDFELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYK3</accession>
    <name>L7JYK3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993839">
        <property type="protein sequence ID" value="ELQ76543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0471"/>
    <dbReference type="HOGENOM" id="CLU_2514225_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYK3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="10013" checksum="B03F9F99221C75AA" modified="2013-03-06" version="1">MLTIKIGAQVQHAQHPSKTYTIAGIKSPTQVLLKHEDEYMLSSVRQLHAVKVQEKDVRTMNDYERFVWERREDVEKQVIDEMMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYK5</accession>
    <name>L7JYK5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase I transcription factor TFIIS, subunit A12.2/RPA12</fullName>
            <ecNumber evidence="6">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="6"/>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYK5"/>
    <dbReference type="STRING" id="72359.L7JYK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0886"/>
    <dbReference type="HOGENOM" id="CLU_1732775_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYK5"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="5">
        <location>
            <begin position="109"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="151" mass="17680" checksum="5CB5AD058CF40133" modified="2013-03-06" version="1">MYLSRYALYFACFPKYYLFFKYFLLERAVGHRSIFNASPSTSILTYLRTGWFSTTINFHPLMFCKCGTYFFTDSICTVCKSRPIKESITYEKYYTLKPKVNTDDRGAMIAQVCVKCGSEKMYYKAVQLRSADEGQTIFYECECGYKMTVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYN0</accession>
    <name>L7JYN0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993836">
        <property type="protein sequence ID" value="ELQ76568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0447"/>
    <dbReference type="HOGENOM" id="CLU_2656202_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYN0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="9048" checksum="9A71D1468618F063" modified="2013-03-06" version="1">MKLFQHEFFKQGHLKNVVIEVQSEELADNPTMCNTEILYERIRTLKFSVDYRNNELQPKRSIDLCLNGNINQYNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYR5</accession>
    <name>L7JYR5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1142"/>
    <dbReference type="HOGENOM" id="CLU_3368783_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYR5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="3832" checksum="9E02EE4A7968D20C" modified="2013-03-06" version="1">MMSERGNSINTVLNNDACRLLTKVNGHGQEANKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYU9</accession>
    <name>L7JYU9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0324"/>
    <dbReference type="HOGENOM" id="CLU_504520_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYU9"/>
    <dbReference type="OMA" id="HPHLNDY"/>
    <dbReference type="OrthoDB" id="10394991at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978906" evidence="1">
        <location>
            <begin position="22"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="537" mass="54573" checksum="FD4FF4F1D3A71295" modified="2013-03-06" version="1">MNRISSPRMLLYFLYISRMYAQTLYDNNYPYGYSPYMPYDDDARNQGYMAQQNANDRAQTLGYPSAATATDMARAAGAAXXXXXXXGAAGAAGAAGAVGAAEAARAAAAAGAVGAARAAGAAGLAGAAGLAGASYANGAARLGLLNKSIYPMNGSYGHMGAGYRNGYYNGGPEYEIFNGRYFEPYNHGHRANRFGSGAHARNFADFEVDMYSGESTQESEELGQMYEDVTGQHNTGLDIGLRGGFGGLAGVAGAAGLEGGLGHGRGSHTIWTHPIGPNALASIVEINELGGPAGHSAFRQERVNNLAHDIANGRVGGMLGEAALKGNGGLTGAAGLGKIIGNEPGFGSNLGAFAGIATASGLNGGITMSPEDLGYEGKESLGATSRVAAAGKLGQSLGIKAGLNAGIADSLSLETLAGLGQGMAVAHVLDDHTNAIKIEGIEGPAAKVAGYAGIPGSGGYGSYASLLGMGPSGSASWAASHALGARGGDAVAENAAFNDVKLIKRLNEDIQRKKEDVIEDTLKKKMLEADLEEELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYX4</accession>
    <name>L7JYX4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993844">
        <property type="protein sequence ID" value="ELQ76525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0485"/>
    <dbReference type="HOGENOM" id="CLU_2943464_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYX4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="6820" checksum="FA3AB9799061A36E" modified="2013-03-06" version="1">MLGCRELNMYENLREEKFLGVLLGGRCPASHDLRVKVTAAIAAYLSIVVRVRAKVLHEATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYZ1</accession>
    <name>L7JYZ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993839">
        <property type="protein sequence ID" value="ELQ76545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0473"/>
    <dbReference type="HOGENOM" id="CLU_903686_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYZ1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="308" mass="35492" checksum="2AFDA303344BF025" modified="2013-03-06" version="1">METISLLLLFQIIIILCFAIISFSAIACLIKSGLAFVFEILSLQNNLIRSTYDPKAMIYTVKGNDDNREAFDHLGNVEYVDVGGKKFVPNCNFNITARIGFNFVFLYEDDLSIMPTKIIFLKQAPDTKISFAELIEFVENNQDTNDINDVAPLNTMLFLALYGYMSHFSISVFKNAIIGYIKHNIYFIIRINSPLKNLSEDENVNMSYPFMAKLVGTKVFVKDKNKVYIIKLRRKDLNIKSFLFLNIQKNNEVAEKIYGNIIKNKLSVGLPKVSTNCLNKWKNMVYSQRIIGFRCKSRWIMFIKKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ02</accession>
    <name>L7JZ02_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993890">
        <property type="protein sequence ID" value="ELQ75992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1044"/>
    <dbReference type="HOGENOM" id="CLU_3034052_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ02"/>
    <dbReference type="OrthoDB" id="2192938at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="5998" checksum="CC84DF277485FB0C" modified="2013-03-06" version="1">MNEAFAEPNLGLINAQNLKLPEFEKKFTLKTDASNTGLGAVLVQENKNGKLIPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ36</accession>
    <name>L7JZ36_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalose-6-phosphate synthase component TPS1 subunit</fullName>
            <ecNumber evidence="3">2.4.1.15</ecNumber>
            <ecNumber evidence="3">3.1.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="3"/>
    <dbReference type="EC" id="3.1.3.12" evidence="3"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ36"/>
    <dbReference type="FunCoup" id="L7JZ36">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0388"/>
    <dbReference type="HOGENOM" id="CLU_002351_3_3_1"/>
    <dbReference type="InParanoid" id="L7JZ36"/>
    <dbReference type="OMA" id="GWEFSWD"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="718" mass="82617" checksum="F8D3B5F4AB14DFDC" modified="2013-03-06" version="1">MEMIKIMYRYIVVNKLFYGITVDKEKENAIIESVCLPLLDLENKQKSSNISALGKAKDPCFIKCYRNPSYASPISTLGNVMFVGIPDNYNQTINDILTDEYKVKIKFFLRDKHCLPVLPDLNKYNYESCKFAQYLKCLAFTREWDALFKDHNEKLMYEDFVNYTKSYYDVLKNVLGENDEVIIMDPELWLLPSYLNNVKVSVAFQIPFFKVEFFKCVYNNMEILKSLLNAHLIFQNKDEMNSFLELCAINIPNFEERSVSAQVLPFGIDTNYVTTLKGPRLNERVAQIKDDYKDKKIIVTVLNTVNSELSENVLIAFNNLLDETEAVLVQIEVHSDLIDAQKRIEMITAISFITTTRGNDCILTITPTNDLEYYSFLAAADLGLFLFDHSVTNKGCCDFIAVNNVPFILSVNSVNHFSSLLVNPNNPNELLEKMKEGLSIGEDDMHSHNMKVLQNMNVGNFLKQIRYDENIAKEKEPKKLEEDKILRAFENANKRVIILDYDGTLTEIVPIPSDAAPSDEIISLLDHLTSLKNLTVVIATGRSKDEADKWFTSSKIQLYAEHSAYYRKKGQWIRRDVDLSWMDTARRVINEYVACTPNTKLEEKNTALVFHYRNADESYRDEQAERCRKALVQALKGRANVKVGKCIVEVNCKDIGKDYVVRQYENCDFGLCAGDDTTDEKMFGRECFVGIVVGKKISKAEYYVNDPKEFKNFLRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZD6</accession>
    <name>L7JZD6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993872">
        <property type="protein sequence ID" value="ELQ76122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0903"/>
    <dbReference type="HOGENOM" id="CLU_1166546_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZD6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="238" mass="27346" checksum="607106ADE0CC6CBE" modified="2013-03-06" version="1">MCCTFVCHETKNGEGQVCDGKEVIVESIGMQQRLNELEELLNKFLLAADSICEAFSSQILYTSSEEIKCALWRIDELQLNSTDSINEYSVRVLNNRVAVAFPCNVGPTASYEVLQLMFTLMLFKIERHFFLQGVLTVIYILQSDINTTNLPRPDGALEGLEVNILEKHENLKEKTSDIKMNEQQIQLQLWLEEMIRRRPKRIYEFLAENNVVSLDGAYIRKILRMRGLCSNITDDVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZI0</accession>
    <name>L7JZI0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Emp24/Gp25L/p24 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993869">
        <property type="protein sequence ID" value="ELQ76147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZI0"/>
    <dbReference type="STRING" id="72359.L7JZI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0881"/>
    <dbReference type="HOGENOM" id="CLU_115931_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZI0"/>
    <dbReference type="OMA" id="VSILCIN"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978912" evidence="2">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="31"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="200" mass="23093" checksum="A69E4E6010C26183" modified="2013-03-06" version="1">MFVFISCAMALIHVLPTNTHLKTYSHSLLANQITQGFFSPLQGSNCKYAVTIESVSDERTLFYSPNLTPNEKTHFSFVNDEPKELRIYIEALPIDPNIPHESGKMQLSFYSKFNTFDKDVAKSHAVEPAIKQLIEFEKLLHQIIVRTQAKKEKMLAIMRSQKTLFASVTFLSFLTFVVFVGVNLYQMKKIEKFFRMKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZI6</accession>
    <name>L7JZI6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monovalent Cation:Proton Antiporter-1 (CPA1) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZI6"/>
    <dbReference type="STRING" id="72359.L7JZI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0436"/>
    <dbReference type="HOGENOM" id="CLU_008635_5_0_1"/>
    <dbReference type="InParanoid" id="L7JZI6"/>
    <dbReference type="OMA" id="AMWFGPK"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="6">
        <location>
            <begin position="17"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="423" mass="47759" checksum="B9A6CF45B3E18313" modified="2013-03-06" version="1">MDDFFLVVCFVSLFILAFGLVSNFVKEKLFLSEPTVSIIFGILIGPYVLNVLNTSYIESKIVMYHFARVVLCIQVMTAAMSLPQGYILKQAKSLFVLVIVVSIAKYFITFIIVYSFSHYNAAVSLAIAACLTPTDPILSSSIVKSKFADENVPERLRTLLSAESGINDGVGLSLLFFPLHIFYSENMLVGLKNYFLNVILYQCMLPIVLGVFIGYFSRKMLKYCYGNDLVGIESFLIYGLALTFFCLGLMETIKSSELICIFFTGALFSWDEWFVLETRESRLQEVTDSLFSTSFFVFFGSRIDFTRITVPVIVSSILIICLRRTFPCLLLFKFIPQIRTKREALFVGWFGPIGVAALYYALLIDRILDTLTIDFVSVVVLFSVIIHGLTVPLFKLSSVKKESRFLGLIAPTRVYDVNTSPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZL1</accession>
    <name>L7JZL1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase of the PI-3 kinase family</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZL1"/>
    <dbReference type="STRING" id="72359.L7JZL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0864"/>
    <dbReference type="HOGENOM" id="CLU_000178_9_0_1"/>
    <dbReference type="InParanoid" id="L7JZL1"/>
    <dbReference type="OMA" id="CARRRTY"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="6">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="299" mass="34564" checksum="DF8298127D2C5F29" modified="2013-03-06" version="1">MVTITSYDEHIVVFKSLQSPKKITYVDQNGRRRSFLVKANDDLRKDQRVMEVFNLLIKYNLKIRKYVVVPISSKLGIIEWIHGLISLKSICMTGQNKQVATEIFKKYKKKLGKHFSTFNSRTKSVLAGWYNDTYKDPVHWHTAKHCYAKTLAIMSAFGYFIGLGDRHCENILVDTRTGDVVHVDLNLLFGRASMLSVPERVPFRLTKNVRECLGVLRETGKFRLYVRGTIRTIVRFRDVIEANLLAFVYDPVAEIRRPGEMIKTFFSKLEGDDLVDRLIKEAVDDGNLGEMYVGWMPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZQ5</accession>
    <name>L7JZQ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TFIIF-interacting CTD phosphatase, including NLI-interacting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993844">
        <property type="protein sequence ID" value="ELQ76531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZQ5"/>
    <dbReference type="STRING" id="72359.L7JZQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0492"/>
    <dbReference type="HOGENOM" id="CLU_078273_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZQ5"/>
    <dbReference type="OMA" id="DPYGCIN"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="72"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="290" mass="34740" checksum="D9561F920FE94E69" modified="2013-03-06" version="1" fragment="single">VIAVLQVCMSNLRLHFKPSFFVPMVRYLNSFLDVGKIENKLQISFLSIFAELRNRISPLSMTKKHQLPPQQQKKPVILFNPENLLLKRYPSFLDLKIVLRPYSDIFLFDLAQNYELISYGMFTPSESKFIYKHLDPYGCINYRINTASIDLNRDTSRLIVIETENRQWDKKYDENILRIESWNGKDDERLFLLDQFLSNLLYTDKKSWLLTLRSYLNTPFFQTYEKVQRKLFFSKNFFNPNYDAFIKQVKDDKLKEFERAKLVMDEQIRKDETIANWIKPIFGLIRQLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZS8</accession>
    <name>L7JZS8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993799">
        <property type="protein sequence ID" value="ELQ76968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0031"/>
    <dbReference type="HOGENOM" id="CLU_2998123_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZS8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6293" checksum="1089F34ECB7DD742" modified="2013-03-06" version="1">MNIHLIKFVYTLGLIPGVQIIYRGLYGLWSMVTTTSSLFSCSALHEVCLCCALLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZV3</accession>
    <name>L7JZV3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993799">
        <property type="protein sequence ID" value="ELQ76969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZV3"/>
    <dbReference type="STRING" id="72359.L7JZV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0032"/>
    <dbReference type="HOGENOM" id="CLU_363767_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZV3"/>
    <dbReference type="OMA" id="MDMRSAD"/>
    <dbReference type="OrthoDB" id="6022762at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="768" mass="87344" checksum="AF1137F51A1996FA" modified="2013-03-06" version="1">MRIKLKLSLNKLHLNSYTLPFPTAQKLVDAFNAHKMHPFIKDMASVIHLTYANKHVTIRREDAKREDPAIDLALDAKIHRKCVPFIKYDRNTVFKRIEEMRAAREKEMSTVYSGLAAHANLLRSAKGRVGKMYVSLVALMDDKYVKLVYRQGMVEDTYVGGFKWVRSARMQDLKAIFEGFLRMYNWRDVKEYVKGEVKYGEEAMKKTPSVGKAAGDFGELRGAEAPHALTPGLGGSLPGRQAVPVGAYTPSQFSSPGQPAPASIFGAGPAPNYSPAPPGFARVTPSPLKHYDMLESHRSEMLKTLNVEKNEAKRKELYRNLELLEMKRREMFRMADLRRRNYNEPAASQPAETTKKEVKGTGAAQRTRVRVKERGEHGKEKTNHDGRNEPIEQRHGLLVQRSVIMKDGGKSMENEYDEMKKNRRVERGGDVRAGMMSDMRNGVRGGIGVDMRGGMEMRSTDLRSNMEMRGGDLRNSMDMRSADLRGGIEMRTTDLRGGMDMRSADLRSVMDMRGGVDMRNERPDLRNERMEMRSGMEMKNELKMGDMRGEMRNERINDMRITPDGRMYMDMRTMDARMDMRQEGRGTQMRMAPEMFMNNTMENRRRMHTPDVMGNVVDGKNTINPRQVLEGGYAPVRGRPKKKIEEKGAHVPVRGRPRTKPRSPGDQGMFTRSEETRANPQYYAQPRSYTMQPPVGFEMSANPMGYSQPIKTPSAFQHVMKMPTPSNFNLQNVQNYSPDGELNVKKNENDDDKGGFGDEAVDMPDFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZZ7</accession>
    <name>L7JZZ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0337"/>
    <dbReference type="HOGENOM" id="CLU_2943457_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZZ7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="7025" checksum="640C1720FAAE5670" modified="2013-03-06" version="1">MKLNGWERQEEVLEVRDNVDSEMIGLCSERYEEVVRSNSGLKDDVDERVARLQGVHYQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K026</accession>
    <name>L7K026_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K026"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0053"/>
    <dbReference type="HOGENOM" id="CLU_141794_0_0_1"/>
    <dbReference type="InParanoid" id="L7K026"/>
    <dbReference type="OMA" id="IRIEVVW"/>
    <dbReference type="OrthoDB" id="10414466at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="16605" checksum="A58856BBAAE699A6" modified="2013-03-06" version="1">MTTENLISPRERMTYITLLCALSVLEITFFGLSSFYSRALKFNSLYTIKGSALLLGNLFLVDAIIQKNLDQLYLYPIVYAFTSALVFLGGEQSTGLCLVFKIVEVGLLLFRGFIAFMLLRKIRIEVVWYYFKKLGPSTQLIGKFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7K044</accession>
    <name>L7K044_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase family protein</fullName>
            <ecNumber evidence="6">1.1.1.2</ecNumber>
            <ecNumber evidence="6">1.1.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.1.1.2" evidence="6"/>
    <dbReference type="EC" id="1.1.1.21" evidence="6"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K044"/>
    <dbReference type="FunCoup" id="L7K044">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K044"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0395"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="L7K044"/>
    <dbReference type="OMA" id="RCIPDIN"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="44"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="256"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="328" mass="38065" checksum="DFED802E0980E7A7" modified="2013-03-06" version="1">MRDNGFVCEICFRIGIYVFQYFNSGMADKIVKSYPLNNEEQIPAIGFGTWQLIGKDNIRTMIQAAIQKGYRHFDLAHVYENEKDIGDVLSEILEKEVVTRDELFITSKIWNTYHDNVDLAIETTLKNLRLDYLDLYLVHWPVSAKPDANFNEIKDQNKNVVLNEFNLKKLWADMERLVETGKTRSIGVCNFGLKNMKSLLSFCKIKPVCLQIEMHPFLKQEELLKLCDANFIVITAYSSLRCIPDINDRNGKVIIDIAKKYGCSVASVIINYLLSKNVVVINKTSRPERLEENMRKVKLSESDINLIDEIKEEKRYIDPKWFGEARFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7K045</accession>
    <name>L7K045_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglycerate mutase (2,3-diphosphoglycerate-independent)</fullName>
            <ecNumber evidence="4">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_0017</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
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    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="4"/>
    <dbReference type="EMBL" id="JH993798">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="reaction ID" value="UER00186"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metalloenzyme"/>
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    </dbReference>
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        <property type="entry name" value="Pgm_bpd_ind"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="16"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="13">
        <location>
            <begin position="98"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="9">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="261"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ELQ76990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="506" mass="56848" checksum="EBC80EB97B275A75" modified="2013-03-06" version="1">MYPLIITPMKRPVKSKVCLVIIDGWGQRNEKKGNAIETTDCKWMKLLSSKYSSYLLSASGTDVGLPADQMGNSMVGHLTIGAGRVVLQPQKQIDALIATHKLKECLENAGVYKESGRLHLIGLVSDGGIHSHISHLFALIDLLKDAFSEIFVHFIADGRDTAPQSAVHYVRSLQKEIAKSENVKMASFAGRWYTMDRDKNLERVEEAYLMMTDGKVIDESIDSYINKQYDKQIYDENIPPVLLNQDGVILPNDTLLFFNYRADRMKQIVERFSRKNRKIFTLTRYDETFNFPFIVHGENVPNTLAETISRSGAAQSHIAETEKYAHVTYFLNGGREQPFENEKRFLINSPKVSSYHLKPEMSIYQIVEQCFKEMTANTPFIVLNFANPDMVGHTGNFEATCEAVLCTDECIGLVYEGCIENDYILVVTADHGNAEIMEDENGNVVTKHTSSKVPLIVCARVVGPAKTEWGFRGEGTLSDVAPTVLHLLGLEVPEEMTGRNLYDENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7K055</accession>
    <name>L7K055_TRAHO</name>
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        <recommendedName>
            <fullName evidence="6">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NIP7 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUA_Nip7-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
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    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
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    <dbReference type="InterPro" id="IPR036974">
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    <dbReference type="InterPro" id="IPR016686">
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    </dbReference>
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        <property type="entry name" value="UPF0113_PUA"/>
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    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="196" mass="23019" checksum="21E72497F61F9926" modified="2013-03-06" version="1">MSILVVTANYFWPSFSRPRRMRRLTQEESDKVFAKLDQFVGDRKDELLKDHNIYLHNKNVFYVSNLLYKKVSNIPKKNIAMIGTHIGRFTRSDRFFLKVGALNVLSAYVTKKVWIKWSAEMNFLYGNNVLKSHVLRTTEDLKDRDVVFLYNPRDVLLGFGITARNMDSFNRADHNSLFIIKQCDKGEYIRNEATIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7K096</accession>
    <name>L7K096_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993841">
        <property type="protein sequence ID" value="ELQ76537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K096"/>
    <dbReference type="STRING" id="72359.L7K096"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0480"/>
    <dbReference type="HOGENOM" id="CLU_046509_0_0_1"/>
    <dbReference type="InParanoid" id="L7K096"/>
    <dbReference type="OMA" id="QHNVHEL"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="255" mass="29491" checksum="D8C97AB6F2F969EA" modified="2013-03-06" version="1">MTTIYREYQIPLPFTTKDYRVAQLYTVAMISANEATGDTSIRIVENKDITDDKYGKCRYTEKIFFLNSKVPRAIRAVVPKKALIVEERAYNAFPTCHTFYTNQAFSTDTFSASVMSTHVNNDLTLKNALNIDRAIYDKTKVKLIDVCSNIVNPQYDPTKTPLKINNDCPLSAGWYENPSYDVMMCYKFVTLKFNCFGLGWLVHEIEKQIDKIFTSSHQQMVCIMDEWYGKSIEDVREIEDSIREKLNEKEGKIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0B7</accession>
    <name>L7K0B7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0B7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0297"/>
    <dbReference type="HOGENOM" id="CLU_1240896_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0B7"/>
    <dbReference type="OMA" id="TEHIDIY"/>
    <dbReference type="OrthoDB" id="10575154at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978947" evidence="1">
        <location>
            <begin position="27"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="223" mass="24717" checksum="92246880F0711816" modified="2013-03-06" version="1">MGIPLHLMITLIAVLFVILSFSRVFCVELNEVESSAPGISTACINSSVAVVDGTRHDEIDCDNLDAVLTKFLTGGCYAGNSNFELQGKDEIICQDENGNYFVIKRMGNGREVVALIDVGNDSRDYSEFYLLIYAREKDLNDLVEIVQQKAKWQIAGEMGNCELVIQPEDFERALGKNELSDHELIAESYIIDLGDGFNSMEQECVSSKVCCLFFVLFCIALIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0F8</accession>
    <name>L7K0F8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ77001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0F8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0028"/>
    <dbReference type="HOGENOM" id="CLU_1069968_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0F8"/>
    <dbReference type="OMA" id="PLHHEFK"/>
    <dbReference type="OrthoDB" id="2189624at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ77001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="30563" checksum="002C5EBC25B52D73" modified="2013-03-06" version="1">MIQVEKIANIVYFDSNLSKDSTLIVSSPNGLLSIIKYNKTEYIKFDIEQKNVVIYPNGDELFTTSDTEQGLRVWDLESKKIVFSYPKDNIKQHVYIQHNNIAALTNLGIKFYDLRMRYSYNFYEAKNVEQLDYNRGLYFATDHAVFMYQNNDKTQIYNSETRIKDLKDGVVLADDHLYFINEQLSKSYCADQILPLHHEFKGQKILVSTLKTNLIDWVGYDHQFKEKFSQFEKIDRAISNEDVFYIFSNKELYGVNFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0G2</accession>
    <name>L7K0G2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Exoribonuclease, phosphorolytic domain 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0G2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0396"/>
    <dbReference type="HOGENOM" id="CLU_106412_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0G2"/>
    <dbReference type="OMA" id="NIHIEIY"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="160" mass="18513" checksum="167A81BD84F3FB3C" modified="2013-03-06" version="1" fragment="single">VETSERDSVTFDDFFLIKDRLYKLFDRFKLGCVIEYKVLRNDGSLLSLFYNAFNVILRGIKLPYISGNYDFVKNQNDNILFQANNSNYYVEMDSINAITYGLIDDLCITDPSFVEEEASDATLTVLYRNDTLNGLYLFSKHGITLETFENFLVSKDLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0J4</accession>
    <name>L7K0J4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_0160</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0J4"/>
    <dbReference type="FunCoup" id="L7K0J4">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0J4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0160"/>
    <dbReference type="HOGENOM" id="CLU_025947_1_0_1"/>
    <dbReference type="InParanoid" id="L7K0J4"/>
    <dbReference type="OMA" id="HWHYSHI"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120236">
        <property type="term" value="P:negative regulation of post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 18" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="30"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="205"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ76837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="419" mass="49312" checksum="52CAD8C8CB7672C5" modified="2013-03-06" version="1">MYQQIIIIGTFANYFISMFLSYRQLLALRRGKRNELLTDKIEDSDFETMKKYNTEKLIFSLFSGTISFIRLICFIHFHTIPKSYDYLKNISGIKSDMVLNVLFMLVFLHFERVMDIPLSLFSTFFIEERYGFNKMTFGIFLKDFLKETIVLTLIISPLYAGIYKIMNYFDTFFAIIFVFVCVFQIFLVMIYPVVIQPLFNKFKELEDGSLKTAIKNLAKNVGFKCSKIFVMDGSMRSNHSNAYFIGLFGERRIVLFDTLIKQATEDEIISILGHEIGHWYHYHIPKMLVLQFSTQFVFFYFLEVALKNKSFVVSLFQTENVPLIVKLVYFSFFMGILSPFLTLLTNMYSRYNERQADLFSIKLGLGENLGKGLISIHKENKSNVCPDWLYSTYYHSHPTLVERLEFISDEEKKLKEKEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YLW6</accession>
    <accession>L7JZX4</accession>
    <name>NFS1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NFS1</name>
        <name type="ORF">THOM_0306</name>
    </gene>
    <organism>
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="452" first="624" last="628">
            <title>Localization and functionality of microsporidian iron-sulphur cluster assembly proteins.</title>
            <authorList>
                <person name="Goldberg A.V."/>
                <person name="Molik S."/>
                <person name="Tsaousis A.D."/>
                <person name="Neumann K."/>
                <person name="Kuhnke G."/>
                <person name="Delbac F."/>
                <person name="Vivares C.P."/>
                <person name="Hirt R.P."/>
                <person name="Lill R."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18311129"/>
            <dbReference type="DOI" id="10.1038/nature06606"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ISD11</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters in mitosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with ISD11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="EF571313">
        <property type="protein sequence ID" value="ABS58597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YLW6"/>
    <dbReference type="SMR" id="B0YLW6"/>
    <dbReference type="FunCoup" id="B0YLW6">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="72359.B0YLW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0306"/>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_1"/>
    <dbReference type="InParanoid" id="B0YLW6"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032047">
        <property type="term" value="C:mitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070903">
        <property type="term" value="P:mitochondrial tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1025">Mitosome</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000382929" description="Cysteine desulfurase">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="1">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O29689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0A6B7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P0A6B9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="P25374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18311129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="441" mass="48744" checksum="A749533D79CCE73B" modified="2008-04-08" version="1">MPLPNQIATSNVETKNFASLKRSDEPIAIAQASRTPAKIYFDFQATTPVDPRVLDAMLPYFTKKYGNPHSRTHSFGWESEKAVETARKQVADLIGAHEKEIIFTSGATESNNLAIKGAVDWKAQDGNPVHVITTQVEHKCVLDSMRFLEEKGARVTYMKVNKDGVIDLEELKRSISDDTVLVSIMGVNNEIGTVQPLEEIGKICKERNVLFHCDAAQMFGKLKIDVNKMNIDLLSISGHKIYGPKGVGALYVRRRPRVRLVPLFSGGGQERGLRSGTLPTPLIVGLGKAAAVCQEEMQRDLSWIESLSKKLYTCLKENIPNVIKNGSLQTNPLRWFPGCLNLSFPHVEGEGLLMALKNIALSSGSACTSASLEPSYVLRALGNDDELAHSSIRFGIGRFTTPCEIKEVAKQTTSAVKKLRDMSPLYEMEQEGIDLKTIKWT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YLW8</accession>
    <accession>L7JX71</accession>
    <name>FRDA_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName>Frataxin</fullName>
            <shortName>Fxn</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YFH1</name>
        <name type="ORF">THOM_1399</name>
    </gene>
    <organism>
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="452" first="624" last="628">
            <title>Localization and functionality of microsporidian iron-sulphur cluster assembly proteins.</title>
            <authorList>
                <person name="Goldberg A.V."/>
                <person name="Molik S."/>
                <person name="Tsaousis A.D."/>
                <person name="Neumann K."/>
                <person name="Kuhnke G."/>
                <person name="Delbac F."/>
                <person name="Vivares C.P."/>
                <person name="Hirt R.P."/>
                <person name="Lill R."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18311129"/>
            <dbReference type="DOI" id="10.1038/nature06606"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EMBL" id="EF571315">
        <property type="protein sequence ID" value="ABS58599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH993936">
        <property type="protein sequence ID" value="ELQ75646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YLW8"/>
    <dbReference type="SMR" id="B0YLW8"/>
    <dbReference type="STRING" id="72359.B0YLW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1399"/>
    <dbReference type="HOGENOM" id="CLU_080880_4_2_1"/>
    <dbReference type="InParanoid" id="B0YLW8"/>
    <dbReference type="OMA" id="RRHEWID"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0410">Iron transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382931" description="Frataxin">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18311129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="107" mass="12434" checksum="873AA4F328D69A1D" modified="2008-04-08" version="1">MLQKIADQRSYLTAAHNTLTALEKKLDNDYGEIEHNNNVIEYTVDGVGRYVVSRQPSVMELWVSSPITGPSKFGMVEKKFVEKKNGMEIMKYFEMEMERIKRMLGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQU5</accession>
    <name>L7JQU5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3278"/>
    <dbReference type="HOGENOM" id="CLU_615666_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQU5"/>
    <dbReference type="OMA" id="IKQVMFD"/>
    <dbReference type="OrthoDB" id="10625137at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="445" mass="50543" checksum="3FD1B7FA53499CD5" modified="2013-03-06" version="1">MKIEIKSKTKLESGVDKKKDADLVKIKKGGRKKAQIEENAVDEKVGPVAEKRTGSKKDETKGKKKEKKEELDEKVKEKEVGEKKKKSVEGKDKEEKKEDKKMKNKEEEGKKAKKETGEKVKKSKKKENVVEEKEKPAPKQSIEAKKKTLRKNEEGKDQSMSISLNKRIRKSDGSSAGKDTAKGALEKKEEQKVVTKKKEKQVAGLLGKTEDQKMVVKKKKGSYRPEELVDQEMAEEKKRGDKVVGLLEKTEDQKMIVGPTGAAEEDSAKKDEQMLGRDEGSRRKKSPRSAKAKKTPAEQPAEVSAPPIGNIFEDVEPIKKDDKSDLLTTKALEKMPPHKELGIENLVFNVYAKLYCFFGEEYTEAIEGTMLVCSDPLRVIFVRKGIKQVMFDSVINYDTKAVLRNARVTFGIIYEDKKKRLDLYAARFFKEEDAKMFYDFISNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR53</accession>
    <name>L7JR53_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_3149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR53"/>
    <dbReference type="FunCoup" id="L7JR53">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JR53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3149"/>
    <dbReference type="HOGENOM" id="CLU_029499_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR53"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03356">
        <property type="entry name" value="LbH_G1P_AT_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="8">
        <location>
            <begin position="280"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ73953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="384" mass="43265" checksum="9A66A351683E5114" modified="2013-03-06" version="1">MPSLKHAFVYYLPRLSFNLRFIRDLYSIKAQTRLFIYMTTKCSSAIILVGGYGTRLRPLTLTRPKPLIPFVNIPIISHQIKKLHEFGTRKIILAANYRTEDIVCQMTKLANDLGIEIIFSVEKEVLGTGGPLALARQYLDEPTPVFVLNSDVICEYPFDELFAAHLACKRKATILTTIVDDPSRYGVILKEGNAITRFVEKPKNYVGNTINAGIYVLNREVLNDIPLKEVSLENEVFAQMAVRNELAAFELKSFWKDIGQHRDYLVAQNLFLSSKGLSNVIDDTAVVRKEAFIGENVVIGKNVKIGAGAYIKNATLMDNTVVSDYCVVLNSIIGFSCKISKWCRLEKLCVLADEVEIKECISLRNCIVLPNKRVSECQDENILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRD8</accession>
    <name>L7JRD8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3092"/>
    <dbReference type="HOGENOM" id="CLU_363774_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRD8"/>
    <dbReference type="OMA" id="ICINDEM"/>
    <dbReference type="OrthoDB" id="2195422at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="837" mass="96457" checksum="0E5117BA8AEBBB7E" modified="2013-03-06" version="1">MGHPCMNNKEGKNEHGAEKTSVWNAAGQDGNAVADGCNSSVTFMNKSESAENDVQRALQDGKEISDDLSELLALLIRYLGAQPKKKDVDCFMCTNREKVLEHPREIHTLFKLYSALVFCMLEHCAALKYEQQLVEDMFNLENYLLDQIAVRELEFMDAYRDEVVDHRREQLIAMGNVFKIDDALHINKEEEIESLTYKFYRKVGDARFFSDAEINLICLILYKRNESFRFFRIFKERKLLINYRLAVLFSLRGECVCGPAEVISQNKNKKFEYEDICAYNLKKLFIRGGVTNPENFFERMKHVLGLDRVQRVDQEIEYEKELKTFEGIVVTKKADVNSREFKKWFSRVNRKHQWMECVKMWVANRKMDKNVVDLSMVDMCCQYKEFENGQFIYEMLEPITSDKVLKDCFIKYCLLCIHALKEGNKKFNDTIVSNLDETFSKMIGGDGSSQGPSKGANRTIKSETMESYYDLKGCSSGRVRKDTDGLLNTNDLLNTNDLVNTRDLVNTRDLVNTRDPLIGRDMNSLVNTNGLVNTNGLVNTNGLVNTNGLANTNDPLTGKEKTADDVLTRKGETLGALSDFKSDICIDVKEVNGASHQECETLITKEEGSRGESVPDTSLTSRSSTESTRSSLVIDVDFIRRWTDRLVILIKKARRLDSDCSVSWDINRSMTEMIINNILYFEKTCRKEVLEALLCDICINDEMAQLLLKGFYCYCLSCKESNVKTISDCDVVYKFAERIYKCWRKKRSGLNLFRRKDPHTKQTIYCCMLGVCCETEKVDQFMDVCKDLKGSSTELTGEMISILKKFHDYKKCNCDFFKNSPNRHYKKHLINHIFKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRI5</accession>
    <name>L7JRI5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994082">
        <property type="protein sequence ID" value="ELQ74044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3046"/>
    <dbReference type="HOGENOM" id="CLU_710910_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRI5"/>
    <dbReference type="OrthoDB" id="2196150at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="389" mass="43304" checksum="663C0C42A2B3F7CA" modified="2013-03-06" version="1" fragment="single">VQLSSISSTIPSTISHQEAGSALNNDTILEIVIKDGDSKENGKGGMRKILRNLQGNVDQNVLVDQILNTLNEKSDVNQIEAVSPDTNGENDVINKLLCVGDDCKNAENESGLFGSKKKKENSSYWTVILGDHGPESVLIKVQTMTVIQSIVPITSSMIIPTIDSRSVSLTYTSPGIEKVKTIGSFGDLFNLSSIKASTSTISKSVDWKEETEKKSTKKKDEKAGKKKYDEKEAIGDEGKTKEEKKKTKKEDKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKKWIKTRRRRLKKKMKGKKRKVEIKHQLPNQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRX5</accession>
    <name>L7JRX5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994107">
        <property type="protein sequence ID" value="ELQ73796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3298"/>
    <dbReference type="HOGENOM" id="CLU_1679200_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRX5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="17557" checksum="B2637C81287B572A" modified="2013-03-06" version="1">MITRGFNCTLSIPNIVSLKKLELSDFDNLSISPKMFTLTKDVIGYVTSMNEDNNADLFASDRNIYLPIIISDYCENISISRNKIAVNIAGVLRNVSKDEVLMRIPPENKSEIVICSPKHPSKLKLHGERICGTITIEKDVYFLSLSRISSDEGSELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS75</accession>
    <name>L7JS75_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">5'-3' exonuclease</fullName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_2808</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JS75">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2808"/>
    <dbReference type="HOGENOM" id="CLU_008978_3_0_1"/>
    <dbReference type="InParanoid" id="L7JS75"/>
    <dbReference type="OMA" id="DVQFRAM"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09901">
        <property type="entry name" value="H3TH_FEN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="138"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ74269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="441" mass="50246" checksum="07E735F426A0149A" modified="2013-03-06" version="1">MGIKGLLPIVSPCLKKRHISSFKNHRIGIDGHSWLHSILPSIALQLYNNVQTTLHHEIFLKRVRVIQKYGAVPVVVFDGESLPSKHVVNERRRMKREEARTMAELQMSKGNVREAMRYIACSISISPHMVAQIAQFLRDNGVEVIVSPYESDAQLAYLQRINYVHSIITEDSDLIVYKCNNVLYKYGNGYVMHYERGAFRTANEFVCDNLLDVSILSGCDYLENVRGVGISSAVKMMRRYGSVELVINEMRRTRSVPEDYLSCFVRARLTFKYQVVYDPVRNERVYLDGSRNEKGYDFLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSF1</accession>
    <name>L7JSF1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3121"/>
    <dbReference type="HOGENOM" id="CLU_2484800_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSF1"/>
    <dbReference type="OMA" id="INKIHFM"/>
    <dbReference type="OrthoDB" id="10556890at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="97" mass="11593" checksum="8D8FAE0A05DFA929" modified="2013-03-06" version="1">MIRKKRKIKLFQTMPSLINEIKKNSAYKNITMSKVKFMQDRIVELGAHKKKTFLPFKEGIMKSVEEKEAIRRERQMRVNVGLLTKNKSTRRKKQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSF2</accession>
    <name>L7JSF2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone transcription regulator HIRA, WD repeat superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSF2"/>
    <dbReference type="STRING" id="72359.L7JSF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2722"/>
    <dbReference type="HOGENOM" id="CLU_283315_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSF2"/>
    <dbReference type="OMA" id="DGQKVCG"/>
    <dbReference type="OrthoDB" id="2192933at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129172" checksum="B4F304790EE7EA11" modified="2013-03-06" version="1">MIISRTCIEHKQNKRRCPIFTIDSLDTFVVTGSYNGEVIIWRIDDSSGSNHGRRPVLPSFTVLQKIYDHKSSVLNARFYGEYLITTGDDNLCILYKQIRYGNEGGARDGERIENEAAKMSEPAGNDTGSNGAQQVNDTLPILEYKKLQVIAHHKADITSLHIKDDSFLTAGLDGLIYVYDFTGSLLNYVDIRTPIKGLYTKDNRTFVKTDTHLLIYEDKTLVSRIVCDGILNESFFARMTSFGKFMVVPSMFNNREDVVMLVSDEEILSLVGFVAPVEVVYVLGNILICGCQDKSVVLWRHEHNYKLRENLYEDEEETAKRAKIDGSKEESVEKSMKDKLPVSNTADEDKRTLVCVQNAVEYSGAGKALNNAEEGKGKDPCGTIDIVAQNEADEKSNGVKPVETEHGTVDKGNVGKGIGVKSVDSIVKHKGNNVKEKEDVLKDNADENIVKEKEDVLKDNADESIVKDKDNNVKEKEDVLKDNNVNNEEKKEENGKNEKQNVNVSAKGSVSKGGSPKGTVTVNKIRQGSYTRPLCLIKNLTTSPILDITTYKKNVLFCSYSGEVVMVTFDKEQIDEIKQEEKADVNIGKELLSITDQRISAFMKSSPKDGIDDTSSSKCDNEFFKIRSDIERKRGRPKMCRTVEMEQVVLDESMMIGKRKVLCQNVGVDSNADVSNATSKKATVKELTNQTDGTAPQPKDSVVKMEQPTSGTQRDKPKRRITPVLIPQLTNYEDKIVSVKNSVYVLFKGNEDYKVMRECIRPVLMKMKEITVRVSCGGSVEQIDGQKVCGDVITRRVEQIDGQKVCGDVITRHVEQIDGQKVCGDPNLTNNAQHDGHSSFNNNEKKEKKGRAGLYTIDVCINDVLRYTLRYRNVRLLAFSHKYIAIHTNVLIVKNVISGQLLLPFIKQNVLYVDIKGDNLLLFMGDTFKIINLRKKKLLVAGSVPFDTYNLCFSKEYFVLGCDLKGNKYFFMKEIGEWCRVNHEESEGFGIVAEKSKERAGLSNEDGDGIIHEMSATANNTGSNAMVDKNVLHVNSPTNNLSIANESESAVTVDNIAISQLFDNDDLSSLELIEYSILKKQSSTRVLSRLRLFISNLRSMTEVIEIRLENIFMNLVMNECRLDVIGILEEMKCTFPVFVYDVLGKIAYLDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSN1</accession>
    <name>L7JSN1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vesicle-fusing ATPase, adenosinetriphosphatase</fullName>
            <ecNumber evidence="7">3.6.1.3</ecNumber>
            <ecNumber evidence="7">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.3" evidence="7"/>
    <dbReference type="EC" id="3.6.4.6" evidence="7"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSN1"/>
    <dbReference type="STRING" id="72359.L7JSN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2583"/>
    <dbReference type="HOGENOM" id="CLU_000688_8_5_1"/>
    <dbReference type="InParanoid" id="L7JSN1"/>
    <dbReference type="OMA" id="NMSHCNF"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="306"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="518" mass="59126" checksum="EE2F1E73791C2672" modified="2013-03-06" version="1">MFFGCEMKFFGVLPRSMTFIPKKASVTRSKISELYIKEHLKEENKIDSVHPRFSSLKYLSYLKPFVHGSIIGPLFRTAEYLRFNLVPRKSLLLVGAKNTGKRFFLKSVCVEYNVNFLESYVDNEKDVCNAYRKALDMEPCLLYLANQLTNEKEKVLHEIEKNMEKVRDKKILTIFSCQSKAFIAENVSKMVTGEVALKTPDENDRRDILASFSLKNFDNVDLGELAKLTPGYLPIDLHNLCVSAASSAIIDNRQVEINDFLRNLTNENKITLDNIGALYAVKKEIEMNILLPLQFPEKFKRMGISRTSGILLYGPPGCGKTMLARAIANTLFCNFISVRGPELVNKYVGDTEKEMREVFNRARNQEPCVLFFDEIDSLCSRRTDNDFQTRIVNQMLTLLDGIDDKGKVFIVGATNRMHALDSAILRPGRFDKIIEVPLPTREEQIDILRKCVRNMPIEPFDLEEIDMDGFTGADIAGLVRESALFALKNDFMNEKLVVGKNDFLAALRDIKRRKQLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JST9</accession>
    <name>L7JST9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septin family protein (P-loop GTPase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JST9"/>
    <dbReference type="FunCoup" id="L7JST9">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JST9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2456"/>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="InParanoid" id="L7JST9"/>
    <dbReference type="OMA" id="ACMNAQL"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="127"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="330" mass="37931" checksum="49305A2F9E4FDF0A" modified="2013-03-06" version="1">MLNSTPFIRENVGEVLTSETVGFSRIPEQARKMSVEKGFSLNILVLGRRGSGTRTLINNLFLSPILSNDRPDGLTTTCAQVTENGVCLNVRISTCHELDEDNTIKFIKSTNFNYFEAQEGLMEDTGDLRVHVCLFVLPTDTLLPGELKLMKRIGEYTNLIPVIGKADTYMQDELADRKAKITELLRENDVKMFVPEELDGENSTATLPMAVTASESLFKINGQTKRGRLYKWGFVDVNDTTCNDFLYLRKMLIGTHLEEIKRSFETNFYEEFRIEQLRMEEKRQMVMKYRGEKLLEAFEEWKNSTDKCDKLTMAKIKDNENMKEVTIHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSU2</accession>
    <name>L7JSU2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2594"/>
    <dbReference type="HOGENOM" id="CLU_486784_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSU2"/>
    <dbReference type="OMA" id="YEMCTIK"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="560" mass="64737" checksum="615A18D50AE10ABF" modified="2013-03-06" version="1">MHDALIIFDVPKETDIKTISPFLTEDNTIRGNDFLVVMAPLNMVNRLKEQNDAPSEHRKTYEMCTIKDLEGKDEGRVQLEQIKYDPPNNELFMLHSENMSYVFLNDFTGQLVKKAQFRGPVVVSNTGRYIVHGLSIYSGAEWLLYGMLPKGNVTFSYDDNFFTVEMGEGLVRIYNAKTLQFTVHEDVNSVQFGRGIVLIDHLVVELVKGSLESYKNLIRGYKSESPGMKNENNTFDHEETLHGRNKTESDRYDNNSVEHDSDENTFMTSSESENLVKGKDESDTDSVLGNWLDSDTNVDVVPDQEDVQIPDYESVHFSPYGYDVVAIDSELNFDRAGKIITRRHPQSTIKIFWTRNRCYAHISKRIGEREKCFIESYSDFVTVNEIGSLKDVKFADQSFLVDDGRVQYYELRNKRFVVVNTVEGADCFDLFDHLYVLGCDEKVKFFDRKTLYMEHNLIAERIEFSRSGLFVGIVSANQVNMFDCNGCLIYKRIFSDIKEFKFLNFVRLDEQTKKEIKGNYEEVVKLLGDEKDLNVSCFKRNDMPVEERKKAWITFLEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSV0</accession>
    <name>L7JSV0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2676"/>
    <dbReference type="HOGENOM" id="CLU_407211_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSV0"/>
    <dbReference type="OMA" id="HATWATI"/>
    <dbReference type="OrthoDB" id="10529674at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="675" mass="78556" checksum="33A94F39F188AB36" modified="2013-03-06" version="1">MNAKGLPSETLQVILSSQILYKHRQLKKQFYIYTMVFSCLSKNLSENQCTLLLEHVLIKKNTTIRQNIHVISLISVVIRRESKLQINDNCKVLLIDSCHGDIHFSRCTFLKSLTIKNYKFTYHKDIYKNLLSLHLEGLNINTTIRLEKNLRIVKLVNLTTGWFKSVEINSNYASIYVRNFNGSLNIPSLLIHSSKIFTRKTTAIAHEVMPGVFGRTMFLDDVYLLKDYEIPNDVESVTLRNFKTNGKAGLKMNKMCKYLKLNVYKGCIDMSEMRNIKNVAFISCLPAFNDNIWEFSDRCKCPVDTTRIEKKNIPNDIENLILERVNVPVDHLLVVNESCRNVAIIFSEGDFDLSKIKELKGLKLIVRGKCFINIRFPDLSNVTTLEVSLDENEEYFNFLLSACINVRKLILYNTVCELHDWIENESMIIYEEGMAPWGLNELKPMIGPEGRVYRCRSIDTLSKDLYVYLEFISDYTRRIVMEDLSITAFSIDNDSLKQLKQFIALKKLCIVAQIIPADLFDNLPFSLRDFSLTLILCHKITDINISTMDDVYVKEKNTKNIKLVNLRLHALFIVNMDRFTSFPVEVEVLEIVPLVKISDALMQVREKMKVRRLIIMQMDFRTRETFRYDYAVEEYFDRLLNVLLQYIDFASIKEIKILDRDAEKSVDPRDYNTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSZ4</accession>
    <name>L7JSZ4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2512</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2512"/>
    <dbReference type="HOGENOM" id="CLU_027721_6_0_1"/>
    <dbReference type="InParanoid" id="L7JSZ4"/>
    <dbReference type="OMA" id="CEQWPPR"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="78"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="278" mass="33306" checksum="0C8A6C8895F5A35A" modified="2013-03-06" version="1">MEKNDFKRFCVVIILTLTLHLVTMPVLLYGQKMNVYRILFLVFHNFFAFWVYFFMILVKKKKGFVEYNEQTTELLRKEPNKYCILCDNYKPERAHHCSKCRQCVRKMDHHCMWLGNCVNNDNLGHFIRMLLYAVLSLLSLSAFSIYSIVRRDKFEPMFLFRTILVFIVIIAVVSSLLFLALGFFLIERFIFVLKNLTYLESCNLEAFKENGMLHLVNSPYNLGWSKNLRIQMGKPYFLYMYGEKGDGLSFEKNFDCEQWPPRQMVERWRQYNEIPFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT86</accession>
    <name>L7JT86_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2823"/>
    <dbReference type="HOGENOM" id="CLU_567658_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT86"/>
    <dbReference type="OMA" id="KPELCTE"/>
    <dbReference type="OrthoDB" id="10548782at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="426" mass="49289" checksum="CD2170B200CEBFF5" modified="2013-03-06" version="1">MVEQEMYTEDKPSSSKTKLDKKHGLIKKSKPDEEDFTEYSEVMTAGQTGGGGNDLSVHDLTGRPGKNGKSMSAMNKYIINFLLIAIYIIIWCYILRNVKCAKWDSTVFQNITDRIYLLFLTTSAFILVLVTSFVLMIDYHRLLFVVHSEVYSYCLVQLFVKYIAPLIKGVEWVEKINGMLSHVLLFYMSILLLFPVIFIILYLMFLSTVKSTAIILMYINFYRFRDVLFYCFLNIFISFFDVILFFTIAELKEASNTIDYIFLAILGIIHLVLVKCIIIVSTIEVLKRRNGDIKDTRYKEVGNIDQSFKGNVSSDTKESINESFGIQKTGLLFYQVIRSIFCNLSSIIVSCVFYFLGVFKFLPFGLNTKIIKFFDRFFCYNVTFTLIISVYDNTITSTLLSTKTQESITFYRPMSHMDSVFPLWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT93</accession>
    <name>L7JT93_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2428"/>
    <dbReference type="HOGENOM" id="CLU_1556440_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT93"/>
    <dbReference type="OMA" id="NICRIRN"/>
    <dbReference type="OrthoDB" id="10252866at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="20340" checksum="6A57D10987F2F57D" modified="2013-03-06" version="1">MEDAINIISDLTKSFLEADAVTYNRIPPKNDQQPALDDLRENNKLLKRQIAQLQTEVKNNELVKEKNDGLFLKYNNERFKYAKRIVSLEKDIEDLKCKLEYWKEEEVKLQENICLIKQPSANTLFLELMSGFNLQFYKKKCKAINVKKNDVIEIDMEGMKNHEITNRVWRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTH6</accession>
    <name>L7JTH6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding Cassette (ABC) Superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2386"/>
    <dbReference type="HOGENOM" id="CLU_2499469_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTH6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="86" mass="9909" checksum="071AFE333625604D" modified="2013-03-06" version="1">MLLELLFQELKKFKSAFKQIIEMIFSSIVPELARFEKLLNIICAQIDELDEKNVLLCCLKPIQFTALFEIVCIGKEITFLKATRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTH7</accession>
    <name>L7JTH7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2714"/>
    <dbReference type="HOGENOM" id="CLU_1205515_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTH7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="230" mass="26558" checksum="DB4BA84C2D53EA4B" modified="2013-03-06" version="1">MIRKYKKERERGSMFITYIVHFIFCLTAVSCINNYENTDKDTGNKQLLDEIARYSSLDRSDLQAPEEQQTSSTQPIDVRVIVETEKQLQSTSDVITKKSVHFKEQPFEMHPLVHDDRKRYDEYEQQHLGIPDKLADVDAKSTKSEQNDRKLICAKGQDDVQEFRGQQEATRCTKFFSLPSKAECGENIIWGIMAAFMTLLLMVVIVGLNSIICVLKPDSFFCFKKFFSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTK2</accession>
    <name>L7JTK2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_2983</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTK2"/>
    <dbReference type="FunCoup" id="L7JTK2">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2983"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="InParanoid" id="L7JTK2"/>
    <dbReference type="OMA" id="WVPRSVN"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ74087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="440" mass="49546" checksum="C50F8BC1729A37E9" modified="2013-03-06" version="1">MREIIHLQSGQCGNQIGTKFWEVISEEHGINNLGQYTGTKDNQLDRISVYYNESSTKQYVPRAVLVDLEPGTMDTLRSGPLGSLFRPDNYVFGQSGAGNNWAKGHYTEGAELIENVMDCVRREAEKSNCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMCTFSVVPSPKVSDTVVEPYNATLSIHQLVENADETFCIDNEALYNICFNILKLKNPGYADLNRLVSLVMSGVTTCLRFPGQLNADLRKLAVNMIPFPRLHFFMIGFAPLIAEGMASYRSYSVSELTQQMFDSKNMMAASDPKHGRYLTVATIFRGNISMKDVDEQLHNIQSRNASNFVEWIPNNVKTAVCDIPPSTLDMSATFIGNTTAIQELFKRIAEQFQLMFRRKAFLHWYTQEGMDEMEFTEAESNMNDLLNEYQQYTYASVEEEIVSEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTM4</accession>
    <name>L7JTM4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2320"/>
    <dbReference type="HOGENOM" id="CLU_2905764_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTM4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7503" checksum="E8376823FE8CB5E4" modified="2013-03-06" version="1">MRAKEHELLQIIDHEEYPLSVISEKCSELMQTFLLLEHSENYTGYNYNYNDNQSNYDVRFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTN8</accession>
    <name>L7JTN8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2238"/>
    <dbReference type="HOGENOM" id="CLU_2460928_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTN8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="10349" checksum="448A4291978C6AC4" modified="2013-03-06" version="1" fragment="single">VGVKHMSLTRHVIFVLVSIKPRYIPVSQVSKFMTFYKYVCERISEYEGMVLTEDMLFSYFLLPSTSCASILRWTCTASLRARSILRCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTN9</accession>
    <name>L7JTN9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Structure-specific endonuclease ERCC1-XPF, ERCC1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTN9"/>
    <dbReference type="FunCoup" id="L7JTN9">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2256"/>
    <dbReference type="HOGENOM" id="CLU_041616_3_3_1"/>
    <dbReference type="InParanoid" id="L7JTN9"/>
    <dbReference type="OMA" id="VECAKYI"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="7">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="208" mass="24567" checksum="1CA64FBA19D3123E" modified="2013-03-06" version="1" fragment="single">VPLSYLKPPFRIPMTIKVSTKQRGNNVLDHLNQVKWYYEDGLTTDFEIEHFISVLFLSLRFHSSKPEYIIARLNNLKEYKTNILLIYVDMHNYEEYMVEFVQFECQVFLCFGNDEAAKYLAAIDMNAHRSTEIIKHRYSFDLYERKIEFLAKIPKINKKDAAALLAGKTCLRTLFDDLMSKASNDVRLSTKKKESIEEYMNMKFTNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTP2</accession>
    <name>L7JTP2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994016">
        <property type="protein sequence ID" value="ELQ74843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2225"/>
    <dbReference type="HOGENOM" id="CLU_145603_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTP2"/>
    <dbReference type="OMA" id="NDKGAAN"/>
    <dbReference type="OrthoDB" id="10487247at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="151" mass="16173" checksum="669DFCE44ABA3383" modified="2013-03-06" version="1">MILTMLLCIVVFLIFLIFVGFAAGYIYSVHKNKEEMNRLMDSQQAKKMGLDSALQDYLVKKDEEVNNSFYGKPINNLYEKAGVIDKDTNKGAGGKGHGTDQQVKGSGKNEGNDKGAANKPDDGGKGPDDANGAGNANKPEPTAPGQNPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTS2</accession>
    <name>L7JTS2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTS2"/>
    <dbReference type="STRING" id="72359.L7JTS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2377"/>
    <dbReference type="HOGENOM" id="CLU_164885_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTS2"/>
    <dbReference type="OMA" id="MPKYFCP"/>
    <dbReference type="OrthoDB" id="2417221at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="14467" checksum="9988CE6FA8B41E46" modified="2013-03-06" version="1" fragment="single">SLHPQMPKYFCPFCDISLPNSLYRSRKTHISGKKHKLLKKAYYLELLENKEVRKTLFDKIDKSLLVKRIFTMPNLKKMPVVPEIPKNIGVFKLPEDFNYEDRRNYDVKLDDVRKVLDGNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTV9</accession>
    <name>L7JTV9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994067">
        <property type="protein sequence ID" value="ELQ74162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2918"/>
    <dbReference type="HOGENOM" id="CLU_1679199_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTV9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18193" checksum="13F7A7BA4A6AB341" modified="2013-03-06" version="1">MPKTLKTFVLRRTMVRECYRIDINSDCMSITIDRAMGNINIPYIPNSNPFDLRDIIWSFERQKNENGSIDKLTISNYPIPIETIDIRRAVRVLILANIAASSESNLIIRDNIENAVITDFHGLIDLFGPNSVIPFEFYLNNDKLMLIKSKKMMVRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTW5</accession>
    <name>L7JTW5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthetase A (AsnA)</fullName>
            <ecNumber evidence="5">6.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.3.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JH994007">
        <property type="protein sequence ID" value="ELQ74928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2136"/>
    <dbReference type="HOGENOM" id="CLU_186148_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTW5"/>
    <dbReference type="OrthoDB" id="10260193at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="ASPARTATE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073:SF5">
        <property type="entry name" value="ASPARTATE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="72" mass="8210" checksum="2E4FEDE97E179CB4" modified="2013-03-06" version="1">MGIRVDAKSLKEQLEKSSCSTITEYHKNILEDKCVYSIGGGIGQSRVMLFLLEKENIWEVQADTEFNNKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTX6</accession>
    <name>L7JTX6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2601"/>
    <dbReference type="HOGENOM" id="CLU_2414862_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTX6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="92" mass="10532" checksum="595CEACDB3017CFE" modified="2013-03-06" version="1">MNQYRVVLSLLSQKDAQLHDVTDIDLDFINLIGQISPGSGLVGDVFYPKILLQNMSIEYDFKIPDFVLYKRIAGHSSVFEDKNRFDRGNKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU13</accession>
    <name>L7JU13_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2873"/>
    <dbReference type="HOGENOM" id="CLU_3320323_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU13"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4623" checksum="37F1BCF55C1A2016" modified="2013-03-06" version="1">MNDIVRRVEELDGNREKMMLGLSDIYKMIHEGLMKLNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU97</accession>
    <name>L7JU97_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding protein of the histidine triad (HIT) family</fullName>
            <ecNumber evidence="5">3.6.1.17</ecNumber>
            <ecNumber evidence="5">3.6.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.17" evidence="5"/>
    <dbReference type="EC" id="3.6.1.29" evidence="5"/>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU97"/>
    <dbReference type="FunCoup" id="L7JU97">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2033"/>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="InParanoid" id="L7JU97"/>
    <dbReference type="OMA" id="YHAEFMH"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="134" mass="15738" checksum="8B9025B752312868" modified="2013-03-06" version="1">MDDKCVFCKIYTQNMNVLYKDARVFVILDIRPLSQGHLLVIPIKHGEFLYENDEEDVSHAMRTIWKIVRVLGIKKFNILQNNGHIQSVPHVHFHIVPYVDQVNCLKVDWKVVDVPSDYVQKNVARLKEELKELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUG6</accession>
    <name>L7JUG6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1957"/>
    <dbReference type="HOGENOM" id="CLU_1316227_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUG6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="24283" checksum="5467B8D57C99CC38" modified="2013-03-06" version="1">MIFFVFFSHTYSILLRELEIGAQKNILEFLEETQESLNKLKNECWLYKEHINTFFSDSGSYPSHQELGDESTLKLYKVKYCELNEEKLGYYERIISHLETLIFEMKKILECEVIPDHSNSATKYISHLQNLLSGTVELLTEEKICVEGFNSLLLTNEIGTTNIINKKLTGFLPLIREERDRVRQLKALEKGFTENALTLCSLLIKCVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUM8</accession>
    <name>L7JUM8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconolactonase-like protein</fullName>
            <ecNumber evidence="2">3.1.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.1.31" evidence="2"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUM8"/>
    <dbReference type="FunCoup" id="L7JUM8">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2068"/>
    <dbReference type="HOGENOM" id="CLU_1391190_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUM8"/>
    <dbReference type="OMA" id="YADERIC"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="196" mass="22431" checksum="D4E17B47C8C30E38" modified="2013-03-06" version="1">MIHTKHTSNFRDVIHQILKEYDGKAANIVIAGGSLLKLLDNADFTKMKTDKWNVYYADERITNTVQDLNHYQSQIFLQHVEAKATLLIEQNIHLYEKLFDEKTIDLALLGIGEDGHIASLFPGKKSLDSNDYICYIEDSPKPPPCRLTLTIRALNKVRNLYFFIPPKDGVVKDVTRPHESILSRITNDITVFLTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUP4</accession>
    <name>L7JUP4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1874"/>
    <dbReference type="HOGENOM" id="CLU_2460927_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUP4"/>
    <dbReference type="OrthoDB" id="10517700at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="10147" checksum="35A528964AD77D32" modified="2013-03-06" version="1" fragment="single">VLSLCAELFVCCISTQKSVSFLVIDGIHVFICACLNVLDMCLMPDTYILADINGIVPYILRHRNDITSKKCTTVYYHEYFDSFRGCNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUS2</accession>
    <name>L7JUS2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spliceosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUS2"/>
    <dbReference type="FunCoup" id="L7JUS2">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2263"/>
    <dbReference type="HOGENOM" id="CLU_030397_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUS2"/>
    <dbReference type="OMA" id="FCPFKAL"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="230" mass="26541" checksum="32B4928B8EB6972F" modified="2013-03-06" version="1">MTDRARELLDRLLGPTRDLTEEEVENLRDTDNCIFLLAGFCPFKALEHTRMDIGQCPYSEHKEVPAKYMAPDKLKLYETELLGLLEMVAGLFENRRKKAGIKEQHVNLLAPNLEEKVKMIVSRAKEGKMDESLELAEKLEAEHVISQPGNDGVNKTHFCEVCAATISNVVDSKEYKVHINGRLHQACVRMRTFLAHLLLKYKFKDATFLTNKKRQQLSKLERINYKKRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUW3</accession>
    <name>L7JUW3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9043" checksum="E733C6894B2A824E" modified="2013-03-06" version="1">MGDDWDIGGNNDDNEWNDAHTQQASANRVEFDPEYVLKKLGIEIRSAYDGDMVLCEGKQRIVKSREKDDNTKEGYNDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUZ1</accession>
    <name>L7JUZ1_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2495"/>
    <dbReference type="HOGENOM" id="CLU_2387721_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUZ1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="94" mass="10809" checksum="78DB224A234E3DA5" modified="2013-03-06" version="1">MNHQKKVISLILISTLCSLIICQLNIIFTVVIDVFVFGFYVLMKSVFEAVVMNQTDIKNEVMEYNNKIKMTRERIEQKNMSNKIVSMPSSSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV43</accession>
    <name>L7JV43_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding Cassette (ABC) Superfamily</fullName>
            <ecNumber evidence="10">3.6.3.19</ecNumber>
            <ecNumber evidence="10">3.6.3.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.19" evidence="10"/>
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    <dbReference type="EMBL" id="JH994034">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV43"/>
    <dbReference type="STRING" id="72359.L7JV43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2443"/>
    <dbReference type="HOGENOM" id="CLU_020421_1_0_1"/>
    <dbReference type="InParanoid" id="L7JV43"/>
    <dbReference type="OMA" id="CKLSMNL"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF116">
        <property type="entry name" value="PROTEIN BROWN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="627" mass="72492" checksum="15F1456CD0C41C59" modified="2013-03-06" version="1">MIIELRDVTIRAKTKDERNRTVYEHILTDVCGEIRAGFTAVVGPSGCGKTTLLKTILGKIPSKYVTTGEIVYCGEKRVLENWTKITTYLDQSDALSGNITTRECLYYAAAFNSKRSESEINDNIDMLAERLYLTKILEHQMNKLSGGEVKRLKVAVELVINAPIILMDEPTTGLDSVLAYRVVQFLKEMAEHDTIIVCSIHQPDDRTLLLFEQVMLMNAGRIVYSGDVREMTRVIAENGFINNNCLEISTYVLDFLNTGRIKYIDPDRHARIVEEMVSKHVQAHRRYKRKYVARKSNEFYISIAPNIHHIITICERELRITFKSAHKQTFQLIFLNLLFMFIPFTLRELLPLKINQEINKTERQIEKEEDLIVVFIQLPICLILTNILICTHGYRHKNDFFAHKEISTHIYSTSSYYIGTMFLSMMYFLPMFILVLGLIRVQLADLFDITSLALIGAFFFASIFFFNFLLDVSKNKVVQHILSTAGLVLNTYSWIVSLTRMNAGQGWFVTIFSVFLQFSPASAILPTIILRVYGNRIAKMKQDEDYTSIRTQVCTRMVHSIQRGIILFLQQYHLSYLMITFLIIFYAAFSYFVTIRPYLYECRVNLSKKIVEEDENEKVSVCVIRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV45</accession>
    <name>L7JV45_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1786"/>
    <dbReference type="HOGENOM" id="CLU_2814237_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV45"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="67" mass="8117" checksum="92047D32EB5FD5FA" modified="2013-03-06" version="1">MDIIIELDDKIQLNGNERIEYIDDNKLVIHMMDKKLVYRIEECLSSYIAVYDEKERYLINHVGKREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV53</accession>
    <name>L7JV53_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">mRNA cleavage and polyadenylation factor I complex, subunit RNA15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV53"/>
    <dbReference type="STRING" id="72359.L7JV53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1891"/>
    <dbReference type="HOGENOM" id="CLU_028601_2_1_1"/>
    <dbReference type="InParanoid" id="L7JV53"/>
    <dbReference type="OMA" id="VSFRMVY"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="202" mass="23281" checksum="3E4CFED3E805BBB8" modified="2013-03-06" version="1">MKKGCSVFVGNIDFDVPEEKLIEQLGTIGRVVSFRMVYDHKTKKSKGYGFCEYETKEIAQLAVKSLNISFNNRQVKINYAENDMKRKNNSWKIEDVLKKMDKVNLLDVLKYLKTMAVNNTGELRRLLRNEHFCALVVGVLVKLGLVDEEGVCEIVGRGMGIEGGKEHVLMHILQVKEEELGMYDEHTRERIMLLKNMLIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVA8</accession>
    <name>L7JVA8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1661"/>
    <dbReference type="HOGENOM" id="CLU_3244857_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVA8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="43" mass="4776" checksum="FA54FECC7648F20E" modified="2013-03-06" version="1" fragment="single">VSEKLATKRILMENSTNIPLHQIDEASSCSFTDLLAISKIFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVB2</accession>
    <name>L7JVB2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993999">
        <property type="protein sequence ID" value="ELQ74991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2075"/>
    <dbReference type="HOGENOM" id="CLU_004199_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVB2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="962" mass="111816" checksum="27089B0BC8602951" modified="2013-03-06" version="1">MCNTSIKSMELYVYASLNARFDSFEWIIPNDELCSQTDNKQDTEKQYYICNSIELLFLFYIKVISGFDSSYNFYFCHTVNEGSSVFNAKNIKVCKNISINSTQKISLTRVKIVSGQVLKINSAYNSLLLEYCTGQFIVSGIQTAVRKYIDLQNTNFIQFYRVEENIYSCKMSGINFSDELLVSHKIRTAQLVNSRLCRTVGLEFKYGCDILHLFNTKGIITSPNNRFKKILLYRYSLDFPIYYLTYHVYEIVISSCCSDFYFLVFIGSTKRIKLYCVELVRYSMVIINHECERIIVRNTTGYFVISNIIKTPSGYDATLYLQDGSIIFEKNLSKRRYSLLLDHVTIDKRTTIRQNLHVIKLISVVISERASLKINNDCEVLLIDSCNGNIDFSGCTDLRFLTIKNYKFIYHKNIYDKLLSLHLEGLNIDTIVRLGTNIKVVKLVDVTTGWFTSVQIKHNCETMYVRNFVGNLTIPYLFNCFSKIFTRKTTTIAHEMMPDRLGRIIFLNNVYLEEDYEVPNDVDSIILQNLKTNGRARLITNETCKCLYINVYQSCIDVSRMKNIRKVAFVSCLPVFEDNLWKFLDPRKCSIDTTDKKRVNLPNNIENVILERVNIPADHLLVVNEHCENVAIIFSEGDFDLSMVKKLKGIRLIVKKKGIINIQFPDLSNVRTLEVSLDGNEEYFNLLLSKCINAKKLIFYNTVCELHDWIQNERFIDYKEGMAPWELDKLESKIELESHVNPCRSACEFSNNCMIHSKPIFDYGRQTIITDLCIIAFFIDSEFLKLLKRFVMLRRLSIVTKTISATLFDSLPFNLNKFSLMLIPCYVIVDFSISADEDIDFKKRNAKNMNLVNLRLHGLVIINMDKFRSFPEKVNVLEIMPLVKINDVEMQVRRKMKVKKLIIMQMNDKQREIVCSNYELEEYFDHLLNALSQCIDFGSVEEIKIVDQGTEKLVDPHDYSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVE4</accession>
    <name>L7JVE4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1599"/>
    <dbReference type="HOGENOM" id="CLU_794975_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVE4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="349" mass="41088" checksum="D2543E11C8777788" modified="2013-03-06" version="1">MHVNPRDKDLSEYSGHNVMLKLDRWRNDLTYKLIIIPSTMEIRSNYTNLRIRAHVEILIENYNEFCEFFSDQVLTIEEFVHHRYCKKEELTSDEKKFMLSVKHKLKKITEKFKFKHNGSTLDEVWYKTVNSTSEKIVLNLDAIQDIIAYLIKEARIIRRAAIKCKIIRYYHEFLYKETIFHEKHDRMMAMRTILANLGFFDSLNNTGTLKTKSNVISNHKHFIEFNSKWVRYREVIAHVGSRYNNETTPSSSISPLIVKAGYDLRNSSLWSNCNTELESDPSFAKLVDTRPENYNWLSNIREHANNNPIIAFSSISIAIIGLVTLISIILKKFTRRKRNYIPAVQIDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVK0</accession>
    <name>L7JVK0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor 5A (EIF-5A)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2323"/>
    <dbReference type="HOGENOM" id="CLU_1644819_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVK0"/>
    <dbReference type="OMA" id="EDCIYAD"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A-like N-terminal" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="180" mass="19806" checksum="FFF90C4D65AFAB3F" modified="2013-03-06" version="1">MYFKSKKIYPLMAISEEEFDSSVNANTLKEKTVIVADADRKDYVRITSVTKVKTGKHGAAKVMISGKNIRTNLKAEMSFSGGSKVYVVVPVKKTYVLVDFDEEEDCIYADPLISTGYAEMETLHCNEIEKDRVKLLLDTIKSAGEDAVIQFATVSCPGLTLLEEISVVGSKKGAPKRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVS1</accession>
    <name>L7JVS1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1441"/>
    <dbReference type="HOGENOM" id="CLU_3322472_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVS1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4705" checksum="5E7777B6BFFE47B6" modified="2013-03-06" version="1" fragment="single">VSVLDFNKKNDLINVIDFYLLSKVHEAYNHLRKFITKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVS8</accession>
    <name>L7JVS8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60s ribosomal protein L2/L8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVS8"/>
    <dbReference type="FunCoup" id="L7JVS8">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1446"/>
    <dbReference type="HOGENOM" id="CLU_036235_0_1_1"/>
    <dbReference type="InParanoid" id="L7JVS8"/>
    <dbReference type="OMA" id="GRYAKSC"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="6">
        <location>
            <begin position="131"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="289" mass="31856" checksum="6766B0ECFB74A967" modified="2013-03-06" version="1">MKNTPKLIFYDFFTLNLYACVSGRLYFVLLTLHFAKFTKNFHPSMGKIIRKVREENKRRFRNIYKNPKVLIPDIKEGCTAVVKEIVHERGRGAPVAKLNVTRGNGVLKAFIVAPEGISVGQTLVFSENAELKVGNCTPLKNVPEGSYVSMVEKKPYDGGRYAKSCGTYAIVVFHNRDAHTTTLKLPSGEKVSVSADARAFIGIIAGGGKDDKPLLKAGAAYHKYKALNKVWPKTRGVAMNPTDHPHGGGNHQHIGHPSTISKHAPPNKRVGLVGARRTGRKKGSRNEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVT1</accession>
    <name>L7JVT1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell cycle control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVT1"/>
    <dbReference type="FunCoup" id="L7JVT1">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2213"/>
    <dbReference type="HOGENOM" id="CLU_090044_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVT1"/>
    <dbReference type="OMA" id="ERFVNWI"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="273" mass="31046" checksum="3312B1F4311D1527" modified="2013-03-06" version="1">MLPLFNMNIRRVLEERTVGFGKPSLNLFPFYVLLSLACISLSIILGYIHITTFQAVLPSSGTITVPRKMTLNLYIRFYDFSQNHILYARSISLDQLRGKKWTDLDRCKPIIRNEGTIVYPCGLVSDTLPFDNVALIGSQGRIEPSTTGIAKNAHKKKIKALMTNIPVTKPPSWPNRTGTLGSEQSDDQVIDLSENERFVNWIQIAAFSRFKKLFGRFDDLEKGDYDVVVDQKGELGRRSVVLREKRLVDVDSYWLPVYLMVGGIFILFPVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW05</accession>
    <name>L7JW05_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1540"/>
    <dbReference type="HOGENOM" id="CLU_1405645_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW05"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="194" mass="22426" checksum="93205C787A5F199E" modified="2013-03-06" version="1" fragment="single">VLFVDSSMPLNSLKKSRRNFKNLKVLSTGNIFEYQPTENDAYNIEKGYDERSGKTSPDSFTSEDVMCPFIKVFYFQVIFQVGLEAFIPLNVSEVFANVEKLVIKNSKPTGTVLCLQKATSDQNLNMKKSITAFIDTFVRKYGRVNVLVIDCENEKSAKLFFSDLLKTHLTEWKLTSLRYEWSEKNNERKVIQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW28</accession>
    <name>L7JW28_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1569"/>
    <dbReference type="HOGENOM" id="CLU_2869242_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW28"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="64" mass="7581" checksum="3365B5C939587397" modified="2013-03-06" version="1">MLFTLQMYKIPRNMNKMSFLDIINKRVSDPMFQCNFVNDSGREVFLSVAYLMFKNKTQKGYESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW29</accession>
    <name>L7JW29_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transport receptor CRM1/MSN5 (Importin beta superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW29"/>
    <dbReference type="STRING" id="72359.L7JW29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1859"/>
    <dbReference type="HOGENOM" id="CLU_443580_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW29"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="616" mass="70886" checksum="7EAFB24AFC820D65" modified="2013-03-06" version="1">MPRPIEVLIVENEDGEIVREKVEGTENLEFGRMMAYKAWQFAHTSPAYAKSHLLQILEGLFSTEDEMNTGTLNTMCWTVGCIQGALSAEDEDPFYVDVLKDLLTLCENRHRKEDKAIIASNIMYVVGKYYQFLRRNTNFLRTVAKKLFEFMREEYEGIKDMACDTLLMICEKVTMHDLQREFVAHVIDNVNEITALLHNYQKRVVYTSLLIVIRGSNDLIERLCAVLTCTSASTRDTCHYVKSHALVLKYYVSAAHAQRILALFNSADLYVKYDVLEYFAEYFRYVAVDERAFEMVRFFVELGPFDHRNLGVLSAFSARINAYEEDEDVSDDFDFNGESRSGRDRESRESSKGRESRSIGESSKGRDIDSTIRGGTIRSGNIRSAAVKGRDDYPINTNSPTNTNPFINSPTNKTIPPLVNAYFTAIVNSVLLPAMPRIKHSDEFSYAYYDLILHSINITFINKILLNDEFIETVYAGLCCQYNTASKCIKILRALYKTSEQHELVLFAERNALRTVENLIGVVLDRDKEYIFCECVLLLQHVLRSSDARDMLVELLCALQNVSREYVMLFVEGMVAIRDRRALFGHAKDFKVRVLEYFDECEYNDELELLKERIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW44</accession>
    <name>L7JW44_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Bacterial surface antigen (D15) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993977">
        <property type="protein sequence ID" value="ELQ75256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW44"/>
    <dbReference type="STRING" id="72359.L7JW44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1804"/>
    <dbReference type="HOGENOM" id="CLU_1409724_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW44"/>
    <dbReference type="OMA" id="AGCFENS"/>
    <dbReference type="OrthoDB" id="2189193at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="3">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="193" mass="22209" checksum="BA178BE1B5588AE9" modified="2013-03-06" version="1">MLYIRARNKQNENISYDFKAGCFENSLFYKLTVLYKSMVMLPFNFFHKLRMHAGVIHGHVHSSEKFFLGDHVRGYVPMSISPLDMNEYLGGKSCIELSNALGYRFRSMKLFVFNDFGFNSRQNNLFETVKSSMLGLLLVHKPSCLGWSTGIGLTVGLHKYKDITTNITMSYAIPLTEPQSKQSFKFEIDFDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW49</accession>
    <name>L7JW49_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993999">
        <property type="protein sequence ID" value="ELQ74987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2071"/>
    <dbReference type="HOGENOM" id="CLU_1714606_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW49"/>
    <dbReference type="OrthoDB" id="10340739at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="153" mass="18816" checksum="0B258FF12067AD30" modified="2013-03-06" version="1">MKCVLEYLNNILRICFYFDQDRNNYESLFHDFSLRKQLKSINRQYTREYIFQTSLFCACSMPMATLFVTQFVSSEKYIKNDFHCKKEALLMNKQRKRFMYLICCITRKEKSLKYCFLFFSGTYCNYYQSEYVEYIANELEPSKQKYFMEMKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW52</accession>
    <name>L7JW52_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1483"/>
    <dbReference type="HOGENOM" id="CLU_043487_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW52"/>
    <dbReference type="OMA" id="HATNINW"/>
    <dbReference type="OrthoDB" id="10539973at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="280" mass="32612" checksum="A0FA7A6E34BECFD7" modified="2013-03-06" version="1">MLKYLNIRLNDTFHVDYDGSHSSESSHLSIIDCLVHIRTLRKLLLNGLIISARTTRALNRLLFVEDIRLCFMIFVIPADACGEVNLWSNKVQTLCFQARNLKKVLLFAKNTRLLNLSKIIMKDELYPIDINFNSIMSVHVQKIRVFVLISGHNPMMITLIEALQDLKTLRIENSSSSFITTLFKSRLIKHRIKELVIVKSFLESIALRRLTVFTRLKSLMLISVTFVPTLNHKVFSKFKNKFTLRIIDSNINFVDFYTIQKYEKIKSFDCYSKDKKSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW80</accession>
    <name>L7JW80_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW80"/>
    <dbReference type="STRING" id="72359.L7JW80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1443"/>
    <dbReference type="HOGENOM" id="CLU_056212_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW80"/>
    <dbReference type="OMA" id="IGNHAET"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="52232" checksum="BDF5C437413C9B43" modified="2013-03-06" version="1" fragment="single">VTCLINCLPFMSIRGPRSALSKFLEEENIKVDKTNKIKENDKRASSDNVITVDAGNNDKRGLTICGRSFKNENNTTRQKRIRYSRPIEIVNLRQELTLRTAVLQKIHENLAVFKLNDEQIVEYSKFLYKNRALTPEIFDCLVNYASKKLVVYDCSMIEKFDICKNFEHLELHYCGQMKNDDISQILRHAVGLKVLKLTGAFLLEKINLRPYINGERKENMNKLIEIDVSHCSRLKDNFIAQVNRYTRIEALNISFCYGITEKSRLKISPRRIVADETRISRKFFKMKDCSLLEELSIANCPVLFFKGKNRIDLCKFTRLRKLNIEGISEMEQIGIDTLEELRAANCFNLSLPLHNDKLRILDISKINYTRDILAKLNRLSRLEYLNISFNENVDDDLIIEYVTTLKNIKTIVVFGCFKLTKELGRLAWLIKNNIKIIGNHAETKYLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW85</accession>
    <name>L7JW85_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Karyopherin (Importin) beta 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW85"/>
    <dbReference type="STRING" id="72359.L7JW85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1754"/>
    <dbReference type="HOGENOM" id="CLU_374766_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW85"/>
    <dbReference type="OMA" id="RINYTEY"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="2">
        <location>
            <begin position="377"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="741" mass="85821" checksum="D68C7C77796120B5" modified="2013-03-06" version="1">MVALRFMTNNKNYQMLTEDELQTEIITCIPSFVHPDQAKRKEVEETFVKMSTNSRYLYVLSKMYASDPRNYFLTGVLLRNSLMATDPTLKKRIEEKYASSTNKEELKSNLMKMSDDISIDCIARIASLELMKNEWPDFFKVASTRSIVLAILYLRDENFDFSNHLEVIYQRLYTEPGNLLKVIFIFRNRLSTDRLNHILKMCIEMSDIPGLTTVFDNFYEFVVDRNLYFTFVNSLADKQPAHVIKFYEVLDCHQCPFEASTLFRHLESADAQIVHSATNLLCNFFDKLFVEKRKEYLPYQDRCMLEIKAYLNNNEKKDSFVLMLGCCPNAYKQCYLDVLIQKNAFWPLSRLAEQRFDDLAVCLPQIVKCCLIAIDKDVNEDACQLLQVLSQQVDGEQYENELSFCFIDILNTLVLTSERINYTEYEKRAALFNALIETVKGCADSQRAGLEKLLFYLISKVKESLKIVDSLNMNEFLILEDILTYYLSLIEELLRKQKETQYIEAVYDIYYDVLNLRRISSLVGDVYISLSALITEHSFFLGKMDELVQFIVRDIKYKRGYDIFTFKAALLLIGDISQVLSKGILKYSFLTELLLNNLSSEHVQRSVKPVLLSVLGDLVFAMGTSYAHKDLTCLMLAEILRLDRSLDILFIDDLKRSALILLDTLLITFEREIDEGLVVGFLARVSSEDERNHSLRQLLDLTYDYVSIYGVNGHLDVINEIIGKGRQGNIDKTDQLLSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW98</accession>
    <name>L7JW98_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)</fullName>
            <ecNumber evidence="3">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="3"/>
    <dbReference type="EMBL" id="JH993930">
        <property type="protein sequence ID" value="ELQ75738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW98"/>
    <dbReference type="STRING" id="72359.L7JW98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1307"/>
    <dbReference type="HOGENOM" id="CLU_947275_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW98"/>
    <dbReference type="OMA" id="PYGYVHA"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="109"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="241"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="294" mass="32319" checksum="39C9B84DF20F1FEC" modified="2013-03-06" version="1" fragment="single">MRTTNKQAQVGLIGLAPMGRALALNLRDKGYVVAVYNRTESRTREFEKECEKEFEEVDNKGRDDVKDNKGKDNKDKDNDTKDKSINDKSTRDNDASGNDESSTRLCDDDTSTSNTNSTPTKGTFIYTYTINAFINALQQPRKILTIIKSDATDDLLAQLIPLLSKNDYILDFSNSTPDITEIRTRDTPCHYLGIGISGGTEGARNNGGLMVGGPSAAYAAVQPILFSISNSVGYFGDGGSGHFVKMVHNAVEYALMGVIAEFWEVLDRLGKHELMASWNEDMRMYLVEAAGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWF2</accession>
    <name>L7JWF2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor C, subunit RFC1 (Large subunit)</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="JH993930">
        <property type="protein sequence ID" value="ELQ75739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWF2"/>
    <dbReference type="FunCoup" id="L7JWF2">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1309"/>
    <dbReference type="HOGENOM" id="CLU_003574_8_0_1"/>
    <dbReference type="InParanoid" id="L7JWF2"/>
    <dbReference type="OMA" id="MLPYSID"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="476" mass="54450" checksum="B2045B96B7AA43B6" modified="2013-03-06" version="1">MEKVMVNWMNTRSDSAGSAYNYADESNYGTLWTVKYEPRSLDEVLGNKTAKEHILSFLEQHTPGKALLIAGPPGVGKSLCVKLACASTVYEMTEFNASDVRNKGSLSERVRQFVNCACISGKRRALVMDECDGMTGDRGGMPELVQIIKNARMPVICICNDKYAVRPLASVCEEVTFRKLETRQILGRIRDILKSEHRAVTDKEIVEVCAMANNDMRYILNCLQGRVMYTKVVSRTLFDEVLALFGRGTAAEKIETFFQDYEMMPMMVYENYLRSEVREDGHVKKDRVNAHKHNKTTKNTRINVYELGESDWHRKMRTYAHASDSISLADTYLRKMGSNDWSLLNQYAVFGALIPAQNIKINRRIEFPKILGNTSKGNKHNKIIQTFHFHILSRCDPTEFYFYDMPLLIKTYIANLNDGHIDKNVQFLVENKLLKSDCDDGMSVYGWEKNVSTKGKSAMTRAYKKLKRSLPYNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWF6</accession>
    <name>L7JWF6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G protein beta subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993929">
        <property type="protein sequence ID" value="ELQ75744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWF6"/>
    <dbReference type="FunCoup" id="L7JWF6">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1302"/>
    <dbReference type="HOGENOM" id="CLU_831632_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWF6"/>
    <dbReference type="OMA" id="AQVPYCV"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="328" mass="36187" checksum="D7B62E7EBA338322" modified="2013-03-06" version="1">MATTSLVERAKSRVHKQLVTSLDVPYTGNSDILYSASRDKKVYQWKLNTSAMERVGTLTKEYTGHNHFITDVKANKTNEMIITTSYDHTARIYDVNTQKYTILKGHKKDLTGVTINTEDNKIITGSCDGSIALWNTEGVLSKVLTPENPSSIPIWVNCVSFVPNTNLCVTGSSDGKLRIWDIDSGKIVRTFVNGNNLEYYATNEIPVPEANMITALSISADGSFCAYGGRDCMVYIITLSDAACLLQFETETPITSLAFAITEPIIAVGTRNGIICWDVIGNERAAIIENESKTVYCTALTWAKTRLVTGYNDGTIVLYDFVRNVADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWK7</accession>
    <name>L7JWK7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWK7"/>
    <dbReference type="FunCoup" id="L7JWK7">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1635"/>
    <dbReference type="HOGENOM" id="CLU_011052_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWK7"/>
    <dbReference type="OMA" id="RTHRVME"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="148"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1017"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="806"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1179" mass="132997" checksum="17CB8871EC9DF105" modified="2013-03-06" version="1">MDGSPPLKKMEEAVKIRNLKNKEESALGAHHKKSMAEMDKETMKKLEEINKSKEDEENRINEMYEQSRVEFVNSLDMDVPKTIFLRVPGVLFACALLSYLIGRLRLNFSLLVLVLYGMYFLFSRNVRKFKKSMAALVFRDERRRKVCELESVEWINFAVERVWKIIEAEVSKEVFRVVNPILAEKCPSFLSQLALSEFTLGSLPPTLKGISFDSRAAQNVVSFDAEVFFVPLETGRGAAMMCLSDSMNWNSRIVLTARLGLSVKGKGLDIPIMVRNLSFAGRMRIILTLAKSLVTPLVSVELCFLSAPQIDFDLCPLKSIDLMNMPGLSTFIHTLIDSNLQKMLVDPNSLTIDLRKKGKEEAAPQGVVLLHLYSLDNTSDMSCYAEIDVDGRRLYKTERREGTRIVYNEYFYVVVHNRDDTVNVTFTSTAVNVSHKYGTAGVCLKKLRSIGSVLQDIKIWRKGTIRAVLETDIKYYPVVHGPVVPNQHMAAQTVVIIGVQQIENLQGQRKPRNRLYNTFCQVMVCEALAGKLQRKDESLTDFLAGALKGAGSLSKNIAGVLTKNLKSGFNTLTGTSEAEDTEALQGASHTTMFVGRTHRVMETRSPFFDEKFEVFCRNIQKDVLYLTVVDQQESENEVIGTVDVPLRDVYDGTEAFFKIKGAQQGRVKLSFAMHYITPFISPFKRYVHAVRIRLVQLVTTYDEGVFYAVVKNRRESFFIDNFCYGDLPINREVIVPAEEDDRLRIFLFRENFNESDFIGEGTVDVVNSTQEVEVVERGEVEGTVTVSVEVEELRGVGCVRCARSGSGGVTGRHSGEEHLDEERSDKHANQNEIEERLEDAVAAGRITDENVLGMEGLAGPVAGPNDEISEKECPVHRDCLSEINPHESEVSSTYLRRDVVTPKPEISDSTYHAVQVAFRHFEGVRENFFIEFVCDDEVIKKSGLIKAREGTADQDAQGMLGVYEHCHLNSNCEVFTLLCGESVVRAKLRTAAFGKTRVIGECVVPKRCMEEKVALGGDAHVLMTVCAQRACFKWRDYFKVGYLEVRILGATKVRGVEKNSMSDPYVKAYLNNTKVYKTKTIQNTVNPSFNESFFCKVNIMTDVIRFDVIDWNRIETDQLISFVEIPLYFVVEGFTEVRLQLIDALKMRKDGSYLHLGFVFNKTYKGGENAKKIAASTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWL5</accession>
    <name>L7JWL5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993910">
        <property type="protein sequence ID" value="ELQ75873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1168"/>
    <dbReference type="HOGENOM" id="CLU_2892291_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWL5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="63" mass="7603" checksum="C76DDFA1722B1D42" modified="2013-03-06" version="1" fragment="single">VDVPSMANNELLNTEKRKKCLENETKNEIIENFEEFSQLKHELTERFAEIDAEIQRKFKKLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWS2</accession>
    <name>L7JWS2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWS2"/>
    <dbReference type="STRING" id="72359.L7JWS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1898"/>
    <dbReference type="HOGENOM" id="CLU_165668_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWS2"/>
    <dbReference type="OMA" id="DAVCTIR"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="95" mass="11288" checksum="1A48644A5C5EDEB0" modified="2013-03-06" version="1" fragment="single">VFCWPCVYHWSTTSSFCPVCMRRMTEYIPLYVDLPLDLDRVVDVCVPPRPDAVCAIKDRTNRRKSRMWSRRGLEVFIILLVIYIGFQLVYRKEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWU5</accession>
    <name>L7JWU5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993897">
        <property type="protein sequence ID" value="ELQ75953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1081"/>
    <dbReference type="HOGENOM" id="CLU_2929226_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWU5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="7125" checksum="3E09480816ACF1B7" modified="2013-03-06" version="1" fragment="single">VTSDLKVVGSNPSVRDYFANLNLPTERLFVLYFNDKLKIIGQQENTIYVFINCSRHDNIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWV1</accession>
    <name>L7JWV1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993905">
        <property type="protein sequence ID" value="ELQ75909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWV1"/>
    <dbReference type="STRING" id="72359.L7JWV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1132"/>
    <dbReference type="HOGENOM" id="CLU_110381_3_0_1"/>
    <dbReference type="InParanoid" id="L7JWV1"/>
    <dbReference type="OMA" id="RKCRNGK"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="122" mass="14146" checksum="422FDE0076851277" modified="2013-03-06" version="1">MKISAKELRTLPLPDLEERYKQIKTELLHVRQKQHTHTVKPHEIYNAHRNVAVVMSVLTEKKKEEAVAAAFAASGKVPRQFLPRLTKKKRMELSKEQLRKCRNGKSRAYKGGLRRVLFAYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWW7</accession>
    <name>L7JWW7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1835"/>
    <dbReference type="HOGENOM" id="CLU_1518913_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWW7"/>
    <dbReference type="OMA" id="IASETCP"/>
    <dbReference type="OrthoDB" id="10392182at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="177" mass="20933" checksum="126E239F71ACEE1E" modified="2013-03-06" version="1">MDKDKRIDDLILEMRNINKLNFELLEKLIKEKDNLVSQEKLNNSLREEVESLSKENRELKNDIIGKSKEIARIKKHSEVAIRRMKHDIASETCPKRRKELSESIDYELKTKILESLLFHLGRKFQFDGELLVDVYKVVNDPKDDFLRRLVDSIKDSHDNYIKMNQADDEIEFNLDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWZ3</accession>
    <name>L7JWZ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1439"/>
    <dbReference type="HOGENOM" id="CLU_2591475_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWZ3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="80" mass="9258" checksum="342FAAF43249C3FE" modified="2013-03-06" version="1">MAVKKFDPTNYIDSSVSERYILAFFSLLGLAAFFRSYFYTYALIPLVCILTVGLERTEQWIVTGFACLYTCLVVKNLFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWZ6</accession>
    <name>L7JWZ6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH993897">
        <property type="protein sequence ID" value="ELQ75954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWZ6"/>
    <dbReference type="FunCoup" id="L7JWZ6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1083"/>
    <dbReference type="HOGENOM" id="CLU_001485_2_2_1"/>
    <dbReference type="InParanoid" id="L7JWZ6"/>
    <dbReference type="OMA" id="RSHCICT"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="250" mass="28489" checksum="1404C730088C2469" modified="2013-03-06" version="1">MVLYKDTMSVFSPMVKRGAGKTYTMLGDNKSLGLIPRAVNSIYDELDETNFTLELRITEIYNEKMKDLISNDNVKGNELETTSVVIRSKDEIMSYINKSIKYRATESTDCNAFSSRSHSIYSLKLKVRTKGETIESMLNFIDLAGSERIKESHVEGKRLKETQNINKSLLSLKIVFNSIINKEKHVPYRDSKLTYLLKSSLENKSKVLMLLNVSLDDKDYNETLCSLRFGQVVNAVYVGRGAKQLVKEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX07</accession>
    <name>L7JX07_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1006"/>
    <dbReference type="HOGENOM" id="CLU_3320318_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX07"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4246" checksum="192104942F5E48B0" modified="2013-03-06" version="1">MGGVALVENYELFVGNNGNTRGINTKRLMSNNEQGKTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXB0</accession>
    <name>L7JXB0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1333"/>
    <dbReference type="HOGENOM" id="CLU_047996_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXB0"/>
    <dbReference type="OMA" id="IPRNTRW"/>
    <dbReference type="OrthoDB" id="2193759at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031505">
        <property type="entry name" value="DUF5098"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17023">
        <property type="entry name" value="DUF5098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="457" mass="53934" checksum="5C0D895F3660B56E" modified="2013-03-06" version="1">MSLITPVLEEYKLAEEKVGWILSFLDHVTTISRRTAELYFRCTQIPRNTRWQDVSIINMVEMMDKSRNSFDELTRMYEITVVVECKAILKKLEDKINELNGLEDRFNKALQKYLDDLMVCRQNHLEAWSNGTADTWLTEKELKKALKKYLNENETWNENLKKEILVYDKELHSISNKYREIIATSLNIQRNHYKSLLMCGEEVLIDEQRFKKDFFFDFPENEDCSIGNKEEKSETKFEDAYEEIMNDMRSRNSEITRDISVKKFGIFRVRRNYDIKHALVIVTETQFIHAYDLDSITLYLELSDEHKALLKKLNDYNRGISFFFGKNEFLNTTEEKQLATFSGYIFNNLNVSRGMLKGFPMTIKDKLIKLDKDKKELIITARKSPMLKNFFVSNTVKIKSFVLRDAYELFFSFCKTVEKKGSSDAKDIETTEVVPSDSKIINYKEDENPWIDEGEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXF5</accession>
    <name>L7JXF5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1626"/>
    <dbReference type="HOGENOM" id="CLU_3162570_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXF5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5798" checksum="5E4B1E12D5BB4C63" modified="2013-03-06" version="1" fragment="single">VRVPVKVHLCTLIGGLKDIDWMRLLKDINRMRLLNNIDEIDREYARYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXH1</accession>
    <name>L7JXH1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_0890</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXH1"/>
    <dbReference type="STRING" id="72359.L7JXH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0890"/>
    <dbReference type="HOGENOM" id="CLU_065181_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXH1"/>
    <dbReference type="OMA" id="GLMCAIK"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ76129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="278" mass="32516" checksum="BF6A8EB7DD964356" modified="2013-03-06" version="1" fragment="single">VNLYELFTLIYCVFKNKLKDKQNMHSLWLFISIVLAVDNNHIKKLLEKLCNTTRFSSIEINLDEPCAYTGFDTTPHDTIPAPVSLLANPHVNTNYLEGSAIWKKIYEVRRDTTHTRLVNGMHFSTFVFICKNYYDQGNGTYLPNKKLFHEKYSQEKYEDFLLLRESMLKTVGFCNTNSLGLHREERKLLEEIKKSLEHSSLVKMDEKRIQDMQKCVNLISCVSCARCKLWGKLKFVGLMCAIKLQNRWTKIDFDEFVCFVNFTNHLVIAYDAVENVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXK4</accession>
    <name>L7JXK4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993863">
        <property type="protein sequence ID" value="ELQ76178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXK4"/>
    <dbReference type="STRING" id="72359.L7JXK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0852"/>
    <dbReference type="HOGENOM" id="CLU_931221_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXK4"/>
    <dbReference type="OMA" id="ICPPNEN"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="299" mass="32482" checksum="8912A33FEF91927F" modified="2013-03-06" version="1">MEIMLIPLLALLIIGLILLSGIGIPLLLKALKNNKGYGAGSKSTPSGTNPSKPESSGPNKPSNDDSDVNPEAAPDETNPDEPEESTPENPCLDEEDVDVGPKICPPNENKPEKGNPENPCVSSDDANPKPLPPCEKTPASPDEEGVDSGLLPPGEKNPASPDEKTPASPDEKNPEEPGNDEEGVDSGLLSPGEKVYPNYPERDESDKPRKDDENTRNPDDDAEWIDLNALAGNRSGEEKAAEEKPEEEKPEEEKPEEEKPEEEKPEEEKADKEKSDKEKSDKEKSDKEKNDKEELVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXS2</accession>
    <name>L7JXS2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.8" evidence="3"/>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0911"/>
    <dbReference type="HOGENOM" id="CLU_1750992_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXS2"/>
    <dbReference type="OMA" id="WYYYNVE"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="149" mass="18160" checksum="32F2CF615C95D958" modified="2013-03-06" version="1">MKFIRPKILLHSPYAEKALLLRLKLSKNRDHINDLILKHAPLHNDKIMDINVYVPYEKMNRIGKVIGKGGCKLKEIERMSNTHIRLRKNDKVYFNITKEAEGDVWMARDMINDVLGDKQRENEVREYSDWEKYYYWWYYYNVENKNKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXW3</accession>
    <name>L7JXW3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1141"/>
    <dbReference type="HOGENOM" id="CLU_2414860_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXW3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="92" mass="10523" checksum="86E3C75963F51C18" modified="2013-03-06" version="1">MNSCCTGSIEKDDAFRGSPINYVLIRFVTKVPDQHDKAPPSRTCSVFSPLRLNNEFIVRALRPLLIRISALLHEPESITVLFKNAFYHHIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY05</accession>
    <name>L7JY05_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin thiolesterase</fullName>
            <ecNumber evidence="2">3.1.2.15</ecNumber>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.2.15" evidence="2"/>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY05"/>
    <dbReference type="STRING" id="72359.L7JY05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0660"/>
    <dbReference type="HOGENOM" id="CLU_008279_1_0_1"/>
    <dbReference type="InParanoid" id="L7JY05"/>
    <dbReference type="OMA" id="QIECLNC"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="40"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="323" mass="37546" checksum="571A681185516EF4" modified="2013-03-06" version="1" fragment="single">VSNTSFCLFPFQYLKLFNFKFLTSLNKMVQMERRVIPAPCRLVNTKNNCFFNSVMQCTMYIYPVVTYFESGEFTKEQRICRRFQGFIKKYIESKVMDPQFFINGLASDIHILDGNEQDAQEFLLLFYGKLTEELGLLDNVSIANVNQLRKIGRTNVMVKTFFGLVLNRLRCMSCFAVTEHTHQFRNLTLDVTESVQESVNKYLKDEVYNSEILCESCEKMAKVSVARQITAFPEVLILQLSRFINVDRKNDSYVVVSDKLQMDKKTYHLIGMVCHSGTLRNGHYVAYAKTDLSWHCFDDMNVSELKDSHISNTGAYILFYSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY45</accession>
    <name>L7JY45_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Zinc finger, GATA-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0623"/>
    <dbReference type="HOGENOM" id="CLU_3282349_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY45"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4616" checksum="927DC97DBDBDBB33" modified="2013-03-06" version="1" fragment="single">VLCNACGLRYSKYRRVCMQCNKVGVKANFEKVSCPKCKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY59</accession>
    <name>L7JY59_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavohemoprotein b5+b5R</fullName>
            <ecNumber evidence="6">1.1.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="6"/>
    <dbReference type="EMBL" id="JH993889">
        <property type="protein sequence ID" value="ELQ75996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY59"/>
    <dbReference type="FunCoup" id="L7JY59">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1036"/>
    <dbReference type="HOGENOM" id="CLU_102602_4_1_1"/>
    <dbReference type="InParanoid" id="L7JY59"/>
    <dbReference type="OMA" id="PEHEQTH"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="78" mass="8918" checksum="0BBE7E5240DE71DF" modified="2013-03-06" version="1">MIKKLTRDIVSEHNNEKSCWVIYNSCVYDVTGYLKIHPGGSKILLRYGGKDITEIFDVVHGYVNIHKMLEGCLIGYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYC4</accession>
    <name>L7JYC4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin---protein ligase</fullName>
            <ecNumber evidence="6">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.3.2.19" evidence="6"/>
    <dbReference type="EMBL" id="JH993856">
        <property type="protein sequence ID" value="ELQ76310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYC4"/>
    <dbReference type="STRING" id="72359.L7JYC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0711"/>
    <dbReference type="HOGENOM" id="CLU_934423_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYC4"/>
    <dbReference type="OMA" id="KNMGRIR"/>
    <dbReference type="OrthoDB" id="2192876at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="298" mass="33980" checksum="955BEBB6C04884BB" modified="2013-03-06" version="1">MAFPDTFIPVLSTRTRIQPSYPTDLISYFLVPYSADCPICFSFHRDAVTLSCGHVYCCTCIKDAQNMVHGSDRAGLSACNGTICPVCDASSYVTVPVKFLFVEPVDEYVLMKRVQGWMEWSSDINDRVKFPFNVVYHDNNIKRADQTTGDRQLCKDMARCGIGTKKNEVMDGTGLCSDRNTDDHGTVTCKKEKRAEMNAGNTTKNMKITDGTGTYTQGDSNSSDKIRFNVIAPPTYNRRDVFYQQNDGQLLFLGLESMKTMKDLPLYIYFKIRKRFSRKNMGRIRHLDWDKEITILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYG6</accession>
    <name>L7JYG6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Prefoldin beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0536"/>
    <dbReference type="HOGENOM" id="CLU_2759597_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYG6"/>
    <dbReference type="OMA" id="QCEQIDY"/>
    <dbReference type="OrthoDB" id="10420307at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="70" mass="8139" checksum="F73B446C6952291E" modified="2013-03-06" version="1">MGGKKYRDLLLQCEQIDYELDVISRYDGSVVYTKDGDVFIPMPKNRAIDQLEKKKKNIVMEINNSNMGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYQ9</accession>
    <name>L7JYQ9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYQ9"/>
    <dbReference type="STRING" id="72359.L7JYQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0564"/>
    <dbReference type="HOGENOM" id="CLU_354967_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYQ9"/>
    <dbReference type="OMA" id="QRAWTIQ"/>
    <dbReference type="OrthoDB" id="2193638at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="88059" checksum="4A71B23A56C27919" modified="2013-03-06" version="1">MLSSYAKIMKGWTSTVNLMKEKINEEKKRRIRESRQDVKKTRMQVKKEEYGEIDDCYVAELEKMKEMARLEEERIFKMREEIKKREIALKEQQKRMEEEKMEELKRREEWKRREELKRVEEKKKMEEKKMEEKKMAEKKKVEELKELKKVEKIKEEKMKNKINARNEVKGVKRGNAQKKDELTKKRREETKKIANERKKANEIKKWEEERRRTVKKQEYNINSGQVRTEKENKSVLKDNAVVDDEMDEEISVIRSTITMKRDNTITGHLVGNRGRRNAVAALKRPVRTEMLKKNEMAGLEKEMKCDDEPGCDLEMVTQKKRSADTTGENVAGVEEKIIKSGPELLQQHLNTLEMNKTHENVKLAGTGMHSVINEGVASAARTRDENAQARTGESIASAARTRNENAQARTGEVNNPFLAANENAKKADVYSARLISALNRDKIEQLQSDVNKRLAEKIVEENKNVLKRKNSNVPACSFSVDKAERVREMSHNEENIDPGLEKMQFHRRMIENSQLVEELMRPLTRKKSGIKISLPKRVSSLRSSSGGDLKDENNSYVRKLNIYRKKHHQTRRQFKRQQILTEKNKKLNQTFEKIKNLFLEKKIRESILVNNSMMDQSVRVEENGRADNTVNTPLFEVPAREALPVSKGPDPIYRRAIDKKISGFKFCTPSKSFDPCTFVPKTTLPFFNAKNEEVFKTSFNKKPWAKEHSIAEIVSNQNHFEIEKYFGVPAIDVCAMFPAVRNISNDSPNRMVNVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYT7</accession>
    <name>L7JYT7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0512"/>
    <dbReference type="HOGENOM" id="CLU_874927_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYT7"/>
    <dbReference type="OMA" id="MGYEMDY"/>
    <dbReference type="OrthoDB" id="10434083at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="330" mass="36760" checksum="C83EC5ABB603D02B" modified="2013-03-06" version="1">MHRKTSANTDKPANSKGGAINTRADEESVRDMARRKLDLIIEEGVEGYERMMQLKLQREFEEMCRIGKGPHIPWSPSRTALESGHASTDSITECFSSCTEGMYTGADNAGEYDSMEAMGYEMDYLADPILGQAVPQKRCSSTCECYGTDSEVDAANERIRQGLKVDADLDALQDIGKEALADDCESAFADEAYGTGRPAEPVLEEKGAVDPFGGACGSAQLIESYEPALGQMGTHPIDPYGGCNTIQMLHYSASEWPIKGKGDPIIDTDFDRYKRDSLLYQEPDAHRWPWQIIEESSGPVNRLSRRTKPSEKRGKKSRKRRSRQRRMYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYV5</accession>
    <name>L7JYV5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1104"/>
    <dbReference type="HOGENOM" id="CLU_1332817_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYV5"/>
    <dbReference type="OMA" id="CTEADYM"/>
    <dbReference type="OrthoDB" id="10355302at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="207" mass="23785" checksum="F70C90E320680BAE" modified="2013-03-06" version="1">MKYLNSGRGLLYLNVVSFILLLISLTVVVFLESQSRLVVELNVFGRKNRNYYLKKNAKEIKNSLYNKGKILVKCARTEKKYDLDFYVDRDANGTIYLIKNGSEIIIICTEADYMRSIDSERLINYYTKHSGYLNVRIEKASLCRKMVELLNDLLQDKIEGDIPTSGLIIYDEKLGLALFFCLNSWTSGVSSRNSLHRSLLLDEIAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYX3</accession>
    <name>L7JYX3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0787"/>
    <dbReference type="HOGENOM" id="CLU_3335897_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYX3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="38" mass="4512" checksum="FE73B0655A87049D" modified="2013-03-06" version="1">MTDHDFIKLSTEPFIYFNTVFHREVNIPALSIFVVRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ39</accession>
    <name>L7JZ39_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">26S proteasome regulatory complex, subunit RPN1/PSMD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ39"/>
    <dbReference type="STRING" id="72359.L7JZ39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1031"/>
    <dbReference type="HOGENOM" id="CLU_543566_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ39"/>
    <dbReference type="OMA" id="RKCTNAK"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="502" mass="55062" checksum="98E6F1BA115F8002" modified="2013-03-06" version="1" fragment="single">VNGLLALSMNRVEEEEVVMALLREGLEENPCNELLLATFLVETYGKELLPLDLLGNILNDIPPERSTPSTVDHRAVAAFVLAASPAYVSSRDEVLTETFINLIEQNKTSNVESLIYILALSILYYRDTSNPEALIKRLDTMGMHGKQALVLLLGMMYQGTGDTSIIEEVLTICFGEQELSKTVEDNEGDEKGEAEKKPGIKISKSDDDETAKTENTNNDEAQEGTLTTTKENVPKNDGISDMDSSNNTEGFAQNGHLEQLGLLAIALISMGDQLSAVMGSRIINASSMLDNVFLKRTIPLCLGLLFNGSNCNFVVDDLLRGITGSDHGILIAKLLGIGLVCSGSNNTTVINALKLVKRCNIRHLAMGMTNLGLGTCSTDIYSYNRKCTNAKGLCGLMFLMIMLLDGEESAIFKEPYFFLSMLPAIKTKIVATARFVSEKEYEFVEREVNVGKKVDVTGMKGSPREITGIYKMHTPFTLKWDEGGENETGLMDFFEDVIVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZA6</accession>
    <name>L7JZA6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Casein kinase (Serine/threonine/tyrosine protein kinase)</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JH993853">
        <property type="protein sequence ID" value="ELQ76381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZA6"/>
    <dbReference type="STRING" id="72359.L7JZA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0637"/>
    <dbReference type="HOGENOM" id="CLU_1521449_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZA6"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="177" mass="20587" checksum="309279BE3A6841AE" modified="2013-03-06" version="1" fragment="single">VCNLKEYLSYKCFISLHLSTKTNEFCIVHWIKNILYTANPLMKTSSNDWPIQSMCNKIQYQKRTTAHPNKIKKSLMIEGDIIGNYKITKKLGQGSFGTVYEVEDSSGTTYALKMESVPVKTTSQLKNEYRIYTDLKGCKGIAKVHYFGKYDSYYYLVMDKLGPSLQDLYERRKKIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZC0</accession>
    <name>L7JZC0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZC0"/>
    <dbReference type="STRING" id="72359.L7JZC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0192"/>
    <dbReference type="HOGENOM" id="CLU_1085972_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZC0"/>
    <dbReference type="OMA" id="NWHEYID"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="251" mass="29872" checksum="1DA4710E1ABE3076" modified="2013-03-06" version="1">MIFEYSLEFRKLYFYSFVNADGLIPERFKVIHVETSGNIVIYTIEREYVISEQLIVDLASHIKEIYCSCNKTINYQSLSLLPSHNWHEYIDLWSCHNSEFKSTLNFTPKARKNCIILGSFFMISDKHIYCCKCYKDRIFYNEVNMSISNDDIIYMAFCKYFESNTYFYINERTEIILFGKSYIGDTKNGRMYPALKVGFKSVKSIERESELMNDFFRKRIFHIMEKNKIDIKILDYDISFIPKSTPAKVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZD7</accession>
    <name>L7JZD7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0177"/>
    <dbReference type="HOGENOM" id="CLU_1679279_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZD7"/>
    <dbReference type="OMA" id="ERTMECG"/>
    <dbReference type="OrthoDB" id="10362380at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18030" checksum="A63E54799CCE7B85" modified="2013-03-06" version="1">MFNEHTIASLLTSLEQLSAQHTHTKDDLKRLKYTKIALSVLAKQLKGPLNTSLQSHLQKYVNLPANTHTSVIKLKNDLVLDEMKRYAKKLRAKAVEFDGCLERDKEHVDKLQMGMTYNVNRTEENVRGAEERTMECGGWFVGSFVVFVVVYLVVRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZE3</accession>
    <name>L7JZE3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZE3"/>
    <dbReference type="STRING" id="72359.L7JZE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0608"/>
    <dbReference type="HOGENOM" id="CLU_142390_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZE3"/>
    <dbReference type="OMA" id="HEKADSY"/>
    <dbReference type="OrthoDB" id="2188412at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="162" mass="19404" checksum="4E45318003B3C825" modified="2013-03-06" version="1">MLECKWKECEYKTENHEELVKHTNNHTNESLTCLWEGCKKLDPHSTKYTLQAHLRKHTGDRPFKCNECEKTYTRSDALNKHIKRHEKADSYNKELIYHINELNGVIDRFKAMIVQERMRNDMLVMNNRLIRKLIAEKILTRAKNEVNGVLHHITKGWDEYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZL5</accession>
    <name>L7JZL5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Cyclin, Cyclin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZL5"/>
    <dbReference type="STRING" id="72359.L7JZL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0104"/>
    <dbReference type="HOGENOM" id="CLU_1269613_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZL5"/>
    <dbReference type="OMA" id="ACEYACV"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="66"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="218" mass="24912" checksum="A5B854828681A424" modified="2013-03-06" version="1" fragment="single">VPSHNFPFPSFFGFLPLSTPKISKKYKSVQSLAKPMLIDITNLPRIPTKTFKLTIHRSTNRAKLLRWLFEVTVDFKLMLDTHILAIRIFDFYVENMRGVCTDEMQKTGICALFLASKLFEVNVRRACEYACVTGGACTEEEMVSMERMILERLNFEMPLVEIEDEKMKIAVVSVLESTKATEWERVIEEAKKTMSGIEEGNAGKAVVFYMGMMKSNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZP4</accession>
    <name>L7JZP4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0549"/>
    <dbReference type="HOGENOM" id="CLU_337762_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZP4"/>
    <dbReference type="OMA" id="YDILHQL"/>
    <dbReference type="OrthoDB" id="10446915at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="843" mass="98798" checksum="F46213319E2D3E61" modified="2013-03-06" version="1">MKDDSSYNYNTIKKKLSDGSILSLDALSEMLKDDSSLLLKLYKEVGNIAIRYKEVNLISLKELLCYGGVIDKLDLELPVIQPVIDYLEINLQKRWGELMNLEELPLYIHKLSSHVKLRIIEMMSEWLNKWNEGSVSLHTNDISSDTNIELCSMEDISDWVTKFSDDMVSKNNPLGSGMLVNMNMSMNTSNADKQIKLTHKSENDLNIKYNEVVNDRAIMNKQENINNIIVNKTTKSNAIKHIKTLVQNLSQTELNNLKLDEYTTSFFIPSVKESFLIPKLFSIEKIIVNDILWNKNYNLLKNKIKTYVNEQSTDNINILLFKLLFGCQMKLSYKDSLILIDKICLDCLVFFLTRNSSTDISQLVYLMEQRRFFYVLILSGKNKISREIIEVINSSVESVNDENYIDKDQVEQLILNVSQDCKYDEMNNGGEDDYADPGLEKSKWCNSYLDAKKLGKRLKKNTSCINYSQARNNQEIGTSDLNNSSCPFVSFICGEVKKFKNIDIEPMDYILYTIKTKQVSSEEKKILEELNVSSYKEIMKEECHSKLHNKPQYEVNEIKEKPFHTKYLSYFFRVKTQNTKVFDYLLTHLPSMNSLNCLKTLTMVFSNKIFYENDFLSDDISDNNKYKSFQHENGDNDACDDAKENPSIEVKNEKHLAKQTFDNYVNSKYNQYKYTFHKLVKTLPKRHVAEILNFPYNLNSFTPCINHFTFNLKKFYQKITYHTVAYRFLNEMKYKNDFLLIILSDKRYDILHQLKFLSELKEKDINETTHQIILNFYLTRVLNSDFVEESHIMYVKEMLDYLLTIQMSTETKRCYDNVLLRTKQYMSIMGLELKVRNVRTTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZR0</accession>
    <name>L7JZR0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0051"/>
    <dbReference type="HOGENOM" id="CLU_141794_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZR0"/>
    <dbReference type="OMA" id="VIPDYPF"/>
    <dbReference type="OrthoDB" id="2191262at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="17151" checksum="DED7ADD0EFAE926B" modified="2013-03-06" version="1">MIPKSNAIYNSNVAFIYVFSLFTLLELSLYGLAVYFLPVVIPDYPFTVYGASLILGNFFLIEAIVSRNIYQICIYPFLYAYTLTVNLLNITLHNKISFAFQMVLISVIVLHGIVFLVKFSDFFYEFTWCYYKKIGGRQEIIRKSKVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZR5</accession>
    <name>L7JZR5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0189"/>
    <dbReference type="HOGENOM" id="CLU_358318_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZR5"/>
    <dbReference type="OMA" id="FIVENMN"/>
    <dbReference type="OrthoDB" id="10610323at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="682" mass="78035" checksum="DE280E01C792E628" modified="2013-03-06" version="1">MAHLKHCWPTSNAWLQSQTLISTILNKWDFFLEETAKLMEMIDNMVDCDLDSDSEEGAKSPKTKFAFTPFRNDTPNDKRLPNNYLNTLQYRSVNSKKKDKASTALKYIDSVTGIENKASLHDFAETSTTKYTTNYSFNRNNGTKPINNSHISQPIPVVRKGSVPQNGSLVDDYHNSKMHQQNTIFNSTNDNSILFDNTLIASEQINSYATTEDDSERIYESMFFPESPYADQTIYSSPRSYIIRSSSTFSGQTCDLARPGSSLISTSPSVNDSSEAREDDFYNLTDEKLENEASNIRNMDIFGLSHDYIESNIRCSSIRTNFSPHNSSLPISIPRCNSNCVRENSPHNVINPSCVKMICEEVKVSGNAANPHQKIKKRAKSKINQEKKTVIITTHIGDLNTAIRKIAQNGIAPDNFSDNKGIICTRTCRDFLDFEMAANDVVLTITCADLSMINNTTKKNNFFCSMLKKLCSNTSEYNISWKIQKSKRNIKIEVFELENVFSYHIFINDVLLHVIKNDNKSIKHGIIFKTLNEKSINNLYIYLNKIFKCESNLFHHLTDYCERETAVIEVDIFNQITNEILLYVSKKPSIDFYLWKKEQLSDLVDQVITDLLNYLFPINRIEHWNESISVKRLCRILASSLTLKEGFLQEGNSRDNMHTTLLELLFDCRNFIIQKEKSVVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZU1</accession>
    <name>L7JZU1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993837">
        <property type="protein sequence ID" value="ELQ76561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0455"/>
    <dbReference type="HOGENOM" id="CLU_2819740_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZU1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="67" mass="7775" checksum="2D7503B91B0A5157" modified="2013-03-06" version="1" fragment="single">VSYRSLLCRLADSDRQLVGNTPVIRASYLREPTPCTGNMNDAKCPRPFCRYKIVRSLPCRHRQSYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZV1</accession>
    <name>L7JZV1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleiotropic regulator 1</fullName>
            <ecNumber evidence="3">2.7.11.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.7" evidence="3"/>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZV1"/>
    <dbReference type="STRING" id="72359.L7JZV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0778"/>
    <dbReference type="HOGENOM" id="CLU_977227_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZV1"/>
    <dbReference type="OMA" id="YSSIRCV"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016905">
        <property type="term" value="F:myosin heavy chain kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="285" mass="32248" checksum="B153CDFE18F7842B" modified="2013-03-06" version="1">MKFSYKKKLKIHDGWINDAVMSSRDGLIATCSTDTTVKVLKKDVLLKTIRTHKLAVNAVAFSDVNPLLVSVSDDRRVLCHDLVTMRIFRSLYGSYSSIRCVHIADNIIGVGDRSSAIIYDLRSSTIINTYNIGRVVNAITMIGTIVVIGSHSLYIVDERKNCSALCVNQNEIREIKRTRNGFAVLSAERIVDVCMDEPWKYTEIKSENAHFTGVQPVNDRFYFTMSNKIILGDKFVNETVEKTNKSVLAVLKETLNGVCVDNDEQMIVAYGESMHYLYRRDFKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZX7</accession>
    <name>L7JZX7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993809">
        <property type="protein sequence ID" value="ELQ76870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0129"/>
    <dbReference type="HOGENOM" id="CLU_2298516_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZX7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="101" mass="11693" checksum="7DA1437FB986C721" modified="2013-03-06" version="1" fragment="single">VRDSGCDYRTIQIPVTKSLFMTVVSLTVTSDVKLSDDELYIVVNRLLTFLHDKRPFLRLLAQQFLDDPELNDRLDIIDRTLIKEEEEKVEKNVKKGNKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZY2</accession>
    <name>L7JZY2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain acyl-CoA synthetases (AMP-forming)</fullName>
            <ecNumber evidence="5">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="JH993856">
        <property type="protein sequence ID" value="ELQ76307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZY2"/>
    <dbReference type="STRING" id="72359.L7JZY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0708"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="InParanoid" id="L7JZY2"/>
    <dbReference type="OMA" id="WYHSIGL"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="136"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="763" mass="86124" checksum="67020EBC4B0A4B5A" modified="2013-03-06" version="1">MCVIQNLTVHNCTTHSIHNLQYNIKETAEYEKSYIHLFLDEVDSRRECDALGIIEDGKIVYYTYGEIERMIRKMGMFIEHVCDDIERESDSNEDDENVTANGSDSTINDRLNGMKGGKNGEDRICEHECSTGRLSKKRSYVGIFINNCIEWTITDLSLILTNKISTTIYATFGKDNVRGIIEQGNVKVVVAGVKEIEMLRGIECLKVVIVVGKERGIEIEGVKVYYYDDVMNGIHKHSGREDIAGTDYAHKYGMGYSTRNYAHKCVNEKGSVICAEPHDETQRLKRPPLPASADEITTIIYSSGTTGTPKPIPLSHRNIYTSIFALKYGRSTNKFVGINAGDHHLSFLPLAHVMERLLIYCFLLINVKVVFYSGDRKKLMDDIRLVRPTIFCGAPRLWEVVRDGIYSKLGVISRLLFKFLLFVKRTNVLNGVYTHDIADFLAFNRVKHMFGGRVRLLFSGSAFLDKDLKIFMESVLGVPMYEAYGLTETTGGVTTSTDKSGVGWPLFSDEIRIVDGELVVKGDNVCTRLDDENYYGDDDDVWKGWIEQEQKAYEKNVRDGRVNIGEYGKNEADGEDNTCGVGDDGRSNSDEKSNTKDDGKDKMHDDKGGVSGAGLFRSTKWFRTGDNAVVVDGNVHIISRLKNNFKTIQGEYIVPERIEKVFKSMCTTFTDIFIAGDTKHSFVVALVVSEYTPEEVQDEIQKIARLKKKEGNLFGFEVPRHVHLVRSKFCDIEGCITVSTGKLCRKGVERAFRKEIEEMMTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZZ9</accession>
    <name>L7JZZ9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZZ9"/>
    <dbReference type="FunCoup" id="L7JZZ9">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0101"/>
    <dbReference type="HOGENOM" id="CLU_073661_2_0_1"/>
    <dbReference type="InParanoid" id="L7JZZ9"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02407">
        <property type="entry name" value="PTH2_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="153" mass="17174" checksum="7CA2FDE7C94D40DC" modified="2013-03-06" version="1">MIQIEDTIYKPLFLTLLSINISFLLYKLICALRRCPIRKSPPNDLVLVIIVNKDLKMSKGKVIAQVGHLISKVFRKAVNVDEWVDNGEAKIVLRAGYEEMKNIGRMAKERGILVNGIYDAGRTQVPAGSNTLIGLGPWNKAEVSVFTKDLKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7K000</accession>
    <name>L7K000_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0654"/>
    <dbReference type="HOGENOM" id="CLU_3279801_0_0_1"/>
    <dbReference type="InParanoid" id="L7K000"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4712" checksum="F7358E1F29AD9FC9" modified="2013-03-06" version="1">MYAQVPSLDPRKIPFERMALTPYYDCFANDISAYNVVVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K061</accession>
    <name>L7K061_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K061"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0571"/>
    <dbReference type="HOGENOM" id="CLU_2628770_0_0_1"/>
    <dbReference type="InParanoid" id="L7K061"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="78" mass="9587" checksum="FC5721B70CB52EEA" modified="2013-03-06" version="1" fragment="single">VWFYWWTVRKDLNKYTATQFFLYKNFLFLMEKNDNKTKRALFQNGIIRHSILLNYFMYRSVTVINLTDKEFGVLSKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7K077</accession>
    <name>L7K077_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S15/S22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993816">
        <property type="protein sequence ID" value="ELQ76761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K077"/>
    <dbReference type="FunCoup" id="L7K077">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K077"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0240"/>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_1"/>
    <dbReference type="InParanoid" id="L7K077"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="128" mass="14374" checksum="52F90BBEDF63DEA7" modified="2013-03-06" version="1">MSDKLAQACTTINNANQNQARQVIIRNINSVVRNFLNIMQAYGYLDEITYINDHRVGKAVVSLNGRLNKCGAVCPRYDVQIGEIERYRQSILPARQFGHLIVSTSKGILDHRECIVKGTGGKVLGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7K083</accession>
    <name>L7K083_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K083"/>
    <dbReference type="STRING" id="72359.L7K083"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0215"/>
    <dbReference type="HOGENOM" id="CLU_1075894_0_0_1"/>
    <dbReference type="InParanoid" id="L7K083"/>
    <dbReference type="OrthoDB" id="10480417at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="259" mass="30201" checksum="237A4EBD5B066DE5" modified="2013-03-06" version="1" fragment="single">VKIQVFMILQGLVCLTIFIFMICNLLDIIPVFKLILLVILIGNIFIGIVSMVYAQALAKKCVLMDVPNCNKKNLFDVEEVVDILNEQQDTDKHDALSFIERKFVENYEQLSVVVVQLQKYMEGGDSKVTHKIDVFRNLINKLLFIETHFSQPNQMYVPVYAMKRFLEDLQQQLAEISYSTLFPIYRDLLECSFFFEREKGNVKSRVSNFLQLNTKRKEEKANEKCKKKIKKICKAKKDYEELAFALTTFGIVFVIMVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0A8</accession>
    <name>L7K0A8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993837">
        <property type="protein sequence ID" value="ELQ76562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0A8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0456"/>
    <dbReference type="HOGENOM" id="CLU_3210264_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0A8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="45" mass="4949" checksum="59391C1C1E85FEB4" modified="2013-03-06" version="1" fragment="single">VGQFKLAYPKEGVAWGTPGGQYVISILLKSLLCYATLLRFMSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQR6</accession>
    <name>L7JQR6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3277"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQR6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="922" mass="106232" checksum="58DD34CC9D05FD21" modified="2013-03-06" version="1">MIMALMLTELYNYVNMCLKYIFLFENEHGSAYEDFLISEHPEDLQMPGLWRTPEILETMQSLSYEIENGCKAHREWEENQICLDRIHYHSHIIGIKRIIYQTHRDVIENNPNTRFKVIKVPISFALRYKTIKLSPYYINDCTTSEICILLKYFVLFSEKVMIQLAKTLCKYLMNEKKLIQEIKMYRDSFCGVQPTSSIINILTPVFGTEETIAQFKRLVRSCIVFNIIDGCFGIKLYGQSQQMNQSNFLIANQDGFALAFFCDKLELCSKWLINNKDKLDTVFSDNMISSPYSVIIKDPVSVDEHANIADTPEKLLNIISTSKFLTGKNVRELTLELSNIHAKVNMLCLKSVNASITVSCMRFSFEFLTSIPSFIKIRIDISNQFNIESLSAIPKNVVHISCEKIRLEHNMEIPDHVESVHIKFSSCDPDKTLVLSKNCNSVIINGMIGTVIFPSVMKCKTKSGKAFEALCFKFETNGTKKQKIMSLSAAVIYTTINIDKEMEMVIFNNVKVEEGSTIVFNDNCKQLKIVKSNGFFDLRPYIGIEHYFDISSVIKILPEKKSFLNLLSIQLHSFHFTQTVKLSNIYESVELKYISAIEGTEIILNKACKKLEIDECKGIINIQEVEYLESLYINFSGDEKDNIEFIGSIRVNQIHITNIFWGICSITSILTNFKDIQCIEFEDISIFMFLYDQSDIYDSLIRHITSKEENGDSSDLLSRLLAVIDRDSDKFIYEAYDLIINFLLKSLIDKGVMDNISKLELGCCIIDTDNCKLLKKLTNLKTLRIRTKKITNQFFYNLPPNLVLLDITDLADNEAKDIEQYVIKPSTIVQQNKTIKILSVKADFIYNVRCLSAMMPSLEILVVQYSPLATDYYPTQKSRIKIRELFIKSGGLHRAPIEMEMIILFIKKLELYIDFESLEYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQW8</accession>
    <name>L7JQW8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3238"/>
    <dbReference type="HOGENOM" id="CLU_3260845_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQW8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4499" checksum="39F689F391C1636E" modified="2013-03-06" version="1">MRMDGKMGGTSMHNLIDAAGDGNGAIVVVREDVEIKRKVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQY2</accession>
    <name>L7JQY2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3219"/>
    <dbReference type="HOGENOM" id="CLU_004199_2_0_1"/>
    <dbReference type="InParanoid" id="L7JQY2"/>
    <dbReference type="OMA" id="NCREANI"/>
    <dbReference type="OrthoDB" id="2160613at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1522" mass="174848" checksum="103179E2870069ED" modified="2013-03-06" version="1">MEYSWFKKANILARYILWFTNDNNSTDNSMLVCDNLGEVQLGKVFGNISHISKEPIDSLSYFEMVEYDTQTDPLGVFESRDEKFTVNDFVDTMVSTGSEKPADSAKYSYYLIRIPVTKRLFMKVVCPISQDKVFYSDIEFYSIIRHLILFIDNSSLFLYFFAQKLMDDPKLLSRLRAIDDKEETLHDRKGDNVYDSCFEMNLTNAMFEINDLTYVAVMDDQNKVAFMSKDGGTKERLPVYVSIRNLDSLLLRQFMVMSGYFLINNYENLYKKYKKSVVERGFNIEVDFSDFFYNNRRKYNHENRLRQVLVKTINEVIGCKFLRLYSIEKCTFWFQGIFANVNLNLPSTAIYLIHFDNCVFEQNVILPANLKKLWIADSEIRNDLVLPNGLEELFFEKVTIAEKVELKIGKDYQLISLKGINGNVYIPGVTKNFCVKFDSSWSFELRKNENGMIEKLHMINVVFEGTGCDISYDIMNMVLENVKVSNENTIVLRKNVIKAELIEFTGLIRISDISQHESFIVRLNSGTCQLQRTDEGDVLELLLSNADLLTTTTLNVNMTNINKRHIYSEDGLHLKLCDSIRNICLRNCFGTLFFQDWPCFSKIMFERKDAYGIKHQTFHVTKSDARTIDRIVIRDFRLDGKIRFGFGVKHIELKNVKISCGSLLIIEDAFQTFTATQCRGIFQLPCISEADSPVITLREYRGYINISLCSKNVYNIIMRNMVFDTSLIIGANINNAEFSDFKVRNYLSFTGKMCNNLTLARFDGPINLHNISSLKKLELRDLDTVNNPHILSVPAEELVAKDIIINEDIIFNSNTKKLYFGSVYKARSGNISIVFNSGCKDIIIEKSHPPINVTSIIRGVTAKDSVEMSSSIRCCLISSCPENLSKLELKDLRLSGAHRIKRNVNFVSLLNVRAWKHSTLILNENLESIRIESSSNVNIDASHVEKLVALTLTEAPMPSYDSQLYNYLTYINMSRMEINKDTAFTEGLDTIILNDVKIGKNSTIKINKNISYLTVLKTHGDIDMRGVAGLNLIRLNELHTLKLRKLQNTDDGYALVLQYFRFERDVRLPDNMEIVQLKHVSTSTGYRLILGKGCKCLDLNYSNVHVDFSQSVNLKKIILEDIPFGSLKMLLEVSSIVDTLVLRKITIEGKMRLPNQMKVVVIQQVKILNGNKLIFNKNCREANIVRCTGKFDLSETTRLDTLVIKPNIERSTSTIIRFPSLEYVRKLEISYNLNSANLQYLLSKCVNVQNLTIHSLDYSERLNVFDSISTILTDINDFLKNDAFYKDAVARYARRTKSESIKDQVKIINAITNVLLRESLDCGRRRNLISLTLVGWCLDDKNIALLEDFHSLRTLVTDYNYFNDKILENLPSQLEILGVTETNSCSVTNADKANPVHFSLKGLEENKNIKHLVLTGRMLINTGVFDCLPVNLLTLKIVWSLWVDIPIPESIVGMITVKKLILNLDTLSYSSPIYIDTNPMKRQYYKVFDILRNFINFDNLDELILETVDEVINIDKMTYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRJ6</accession>
    <name>L7JRJ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3188"/>
    <dbReference type="HOGENOM" id="CLU_2110654_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRJ6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="115" mass="13407" checksum="10FCA909276BB073" modified="2013-03-06" version="1">MLLNAVRLETLGIITTLRHTFFAFKNAHTKRNMHFFSFFVLLCAKLSQSMEEVENEFLKKTQEQNNGNEEKECPQIPDGSKKNLDNMNKCRSKLDKKENALKERKTKVYGGSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRK5</accession>
    <name>L7JRK5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3016"/>
    <dbReference type="HOGENOM" id="CLU_3371053_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRK5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="3872" checksum="8C9C2D9B000E9A36" modified="2013-03-06" version="1" fragment="single">VVNQKEEQSTPENANSVNAQEVQLIIEDNMATRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRQ2</accession>
    <name>L7JRQ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-related small GTPase, Rho type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_3115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRQ2"/>
    <dbReference type="FunCoup" id="L7JRQ2">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3115"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="InParanoid" id="L7JRQ2"/>
    <dbReference type="OMA" id="EVNHYIP"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ73975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="208" mass="23713" checksum="88298D496DF8826E" modified="2013-03-06" version="1">MKHIDVCSMYEAQHSVSGKIVVVGDGACGKTCLLEVFKRNKFPDEYIPTVVDNFVKEVKINEAECVNLTLWDTAGQEDYDSVRPLSYKDTDLVLLCYTIENCQVLSNIPKKWLFEIKNYCPSANFFLIGLKKDIRDEQRGHVQGIVSFEEGQNMANEIGAQAFIECSAKSGENVDKVFLESAKYIMAFKKRIKEQPSWFKRIFCCGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRQ6</accession>
    <name>L7JRQ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Actin-binding, cofilin/tropomyosin type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3120"/>
    <dbReference type="HOGENOM" id="CLU_138659_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRQ6"/>
    <dbReference type="OMA" id="STYVIFH"/>
    <dbReference type="OrthoDB" id="2189548at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="156" mass="18132" checksum="CD728CF2C00FD29B" modified="2013-03-06" version="1">MVDAMPNKMDGVYDQIAKVNRRESTYVIFHVPNVRDARFQLLAVGGSINPDASRLPTVDDIRKRFEECREEVIKYDSCYIVYDFYFNNANGASRNILILISFINDETCPTNKRFFYSSHSLELVNDIHAAKHISVNSPSEFTYDYFEEVCRSHKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRW5</accession>
    <name>L7JRW5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA delta(2)-isopentenylpyrophosphate transferase</fullName>
            <ecNumber evidence="6">2.5.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="6"/>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRW5"/>
    <dbReference type="STRING" id="72359.L7JRW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2881"/>
    <dbReference type="HOGENOM" id="CLU_659824_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRW5"/>
    <dbReference type="OMA" id="GYKESYN"/>
    <dbReference type="OrthoDB" id="2195148at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF60">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01745">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="417" mass="48261" checksum="632432AFF4B093BC" modified="2013-03-06" version="1" fragment="single">VLISFYLSIILVIHTVYFVTRLVHRPQYLCFIVLPFNTMHPMSQIICLAGATGTGKTALALKLAHNLNTKILSCDSVQIFRELNIGSNKERENHLMVDVKHYGEKYDVEKYVNDSLNVIKNMEDCNRLVDCDGSVRVLVVGGCGLYMERLSSCCANVVKVFLFKNRRVLYRDLDRRCEEMVLNGLLEETLRVCVRNDQINGKAGAFNPCSYGDNVLRDNIVGCSLPCVDKSLSTVENDDKHGMDSYERKCCVENAEEDKVNDKVGNSGNGNEEHQTTTGMNETCFNVNNHVIRNDDIVSTRLLPIGYKESYNFLIAGDYSYNAFISFLNTFKKNTRNYVRRQETFFKRKNYVFINAERDDLMERIAGVIEGERVSDEYAFKYFKTLKQYKTENTYFKTEEDYEMFRKRCYYLQLERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS86</accession>
    <name>L7JS86_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994046">
        <property type="protein sequence ID" value="ELQ74338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2746"/>
    <dbReference type="HOGENOM" id="CLU_2892292_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS86"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="63" mass="6979" checksum="ADA8E35F9DE5F93A" modified="2013-03-06" version="1" fragment="single">VQSPRGEMSGEQRQPAWNGGPQRVIAPWVLGERSSGVWYCTVKGWQRPSKAKYGSETDSGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSB5</accession>
    <name>L7JSB5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2903"/>
    <dbReference type="HOGENOM" id="CLU_348579_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSB5"/>
    <dbReference type="OMA" id="HAMHEIN"/>
    <dbReference type="OrthoDB" id="10516735at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="750"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="825" mass="92776" checksum="7721F6CEAB36C49F" modified="2013-03-06" version="1">MRKYFFNSLAIVRIQIIGALFFIGKVYFFIGALNAVLVTVLVGMISAISSVMVIQVREYVCGGRTSADTECMCEAGRVKSGSARQLNTIFGADGQCKADDGNCNESIEDEILKENEIMHKRPYGDEHRKMRKINDAEHTLHNKNKNDAANTNYAMHKKRLCGMKEKKKCVEEARHCEEQLCRECVKTSEVKLEGGCVEGQNNNKTRNKAVIKSVNKTNTTKGVGNTTCAKRVGNCMNALPCNKTAAKLKKHDDNLFMHEQRANKSKIVQEHKFNIDNTNKNACIAATRCSSQQSMRMIVSNPIDTSVPKTCQETDKRINHAMHEINNHERIKGGIKGYASYGSLTDGTEEQTLVCRVGESPTNKIGVDRKLAVNNTSNKISAGSIVNTGRGNSIVGQKKSKDGKHEISSTVRHDKGVDKGNVGVKGVNKKKVENIVHKQKSNYKNDLKSGLVNTRPKGERKLNYRNDLKNGLVNTRPKGEHKLNYRNDLKKETRSMNALNKHKRTKNEQSSGKKKSKSNVRDETTSTTESIVMIPKNKKIKEMVIEEGITYDALIRQVLGNKSCIFFFLCNLVLDLITLVINLKVSYNFLEDVLKFDAKLILGIIFFSTFLTFEKGHFIVGVGEAIMIVIFITASVVEHFYHCTRVYASTSTTRDALSLFYALHNTAFLIWSFYTQPFALNHKKRQIILFNALTCCTLTVLGIIRHLTFLKTSNHFITIPYMNDVLRLLIVVLQLLTFSKLINKMCKKRASRIFIFVAVFLCSLFVDDFFYLKALFFFFGSACMFVLPFVMHVKCYGVGWNSLMGGVGMMGIVYGAVMVFKIKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSH7</accession>
    <name>L7JSH7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar sorting protein VPS1, dynamin</fullName>
            <ecNumber evidence="5">3.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.5.5" evidence="5"/>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSH7"/>
    <dbReference type="FunCoup" id="L7JSH7">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2681"/>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="InParanoid" id="L7JSH7"/>
    <dbReference type="OMA" id="IQRRKEC"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="529"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="615" mass="69329" checksum="12D89E114092E1E5" modified="2013-03-06" version="1">MSSSNPMALLIERINTLQDICTESGITNMIELPQIVVIGGQSCGKSSVLENIVGTDFLPRGVGIVTRRPLILQLIYSKEEYVRFNHSERTFTEYEHVRQEILAETARLIKNKHDVSHVPITLKMYSPHVMTLTLVDLPGLVKVPTNDQPKNIVARVEEICKRYIVNKNAIIIAVSAATSDIASSDALQLAKTVDPGYERTLGVLTKVDLMDTGTDVVDVLAGRVLSLKLGFIPVVNRGQNDVKNNKSIGDALADEQRFFETHRAYRRNRAYCGTAYLRTKLTSILYEHIRHTLPELQERVNTLIARTQAELDELGAFDLTPKEHVLRTINEITKKFGDLLAGTAERGEELCGGARLSYTMHQSFAAFINSLNALHNMRNDHIRTVMLNASGSSSTLFFSERAFEMLARQSIALFKPHVLKLVSVIFTEMVRMMHTVVNTRFARLNEKISGALIALFKKNSEHTSMLVSALIEWNTAYISTRHPDFVRLDELAKLSECKTSDQPAVKAFDKLPNVLRLDKEVSDGESAEINLIKSLVASYFDVNRKILLDQVPKAIMCNLVMRSAQQMQEHLFREVYEMEGVEQLCEEDGSVKELRERLKRNLKAMRQAHDLMCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSH8</accession>
    <name>L7JSH8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ74006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3099"/>
    <dbReference type="HOGENOM" id="CLU_702482_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSH8"/>
    <dbReference type="OMA" id="RIKRTMI"/>
    <dbReference type="OrthoDB" id="2193164at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="366" mass="42529" checksum="CCA1607D296E488C" modified="2013-03-06" version="1">MKNKIEIVKSTARVNRIKRTMIRFKCINERKYTLITAQIMGYVTTPYAQKCFMQSVPVPLLVNEVFVSRTVHFNAFLPSNLPPSIGALQSSVKYFIVVKVFDGKDELACIKGKFRLLSDTSTYDFREIYMLNQNCCRVGSRTYEEHVLTLIRNKLQGCDQVRCLTAVLDAQASKESQNTGQAETNDRKSAADTGTVPTHKTGEDRNVQDAMQDLRIEENRTEAEILEYKLAKINEMGLLNDIKSAQLKYKRESKPNLHILLDNEHSEEQKLIKLVIKDKKVKLAEIKMKNFFYTNDENVFNIRLLKEMKKIKAVVKMKEEAEYTSKETVLFIFERHNLEYLLHMNVFLTRFTRCTFNSDLFKVNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSN4</accession>
    <name>L7JSN4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994048">
        <property type="protein sequence ID" value="ELQ74305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2776"/>
    <dbReference type="HOGENOM" id="CLU_1476151_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSN4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="183" mass="21644" checksum="F068258ADAA0A3B4" modified="2013-03-06" version="1">MNYVHFVIRIPVTQHLFMKVIRLNSHGKVEFSDNEFYNTIKHLIMFVDNSSFILHLLVEKLIKNSRLWDRLKKIDKKNNNKSKTDAISYNQFEMNLSNAMMEINNTTYLAVMDNQKNVAFISENSSTRAKTPVYVNLRNLDALFLRPFIVMNGYFLINNHKELYKKYNKSIIEHGLNIEVDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSR3</accession>
    <name>L7JSR3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2982"/>
    <dbReference type="HOGENOM" id="CLU_3144015_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSR3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5273" checksum="30D15B116014D1E8" modified="2013-03-06" version="1">MYDIGVRQGTPGRGSHAIHDLRVRVTAAVAEYLSVVVKGCAKLLHEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSS5</accession>
    <name>L7JSS5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2992"/>
    <dbReference type="HOGENOM" id="CLU_3038214_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSS5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="6454" checksum="D14E1470F4B2547B" modified="2013-03-06" version="1" fragment="single">VNRLDDDTIVYYIRAALKIRFILLIDLYQEINVDKLNSNYQLLIVQLLSSLVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSY9</accession>
    <name>L7JSY9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin/40S ribosomal protein S27a fusion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_3237</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSY9"/>
    <dbReference type="FunCoup" id="L7JSY9">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3237"/>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="InParanoid" id="L7JSY9"/>
    <dbReference type="OMA" id="GVFMAFH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ73862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="150" mass="16920" checksum="1123F1343F2B3FC1" modified="2013-03-06" version="1">MQIFVKTLTGKTITLEVESSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGKKKKKKVYTTPKKEKPKRIDTKDVVLTQFSVDKSGNVSVLRKECVQCGPGYFLGHSKGKEYCGHCHEVKMVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT74</accession>
    <name>L7JT74_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding Cassette (ABC) Superfamily</fullName>
            <ecNumber evidence="10">3.6.3.25</ecNumber>
            <ecNumber evidence="10">3.6.3.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_3158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.25" evidence="10"/>
    <dbReference type="EC" id="3.6.3.29" evidence="10"/>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT74"/>
    <dbReference type="STRING" id="72359.L7JT74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3158"/>
    <dbReference type="HOGENOM" id="CLU_020421_1_0_1"/>
    <dbReference type="InParanoid" id="L7JT74"/>
    <dbReference type="OMA" id="RRRCKLE"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ73962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="625" mass="72241" checksum="6230D8B1302F7EDF" modified="2013-03-06" version="1">MDVDWRNIDIEVRNRNKRYNQKRIKLISDACGHAEQGLLAIIGPSGSGKSTLIKALAGRLAKDAASTGVVTLNGIERDIKTWTSVVGFVDQDDVIYKRLTARETVKYTAKFKLRDKNIDVDKKIDKLFERLGIAHIKNCKMTNLSGGERKRVMVAVELVSDPRLIFLDEPTSGLDSNSALKIIKLLKDLAMAGRTIIFTIHQPDDILTDEFDEILLLSQGRSVYLGKVAKCEEYLISKGFEKHKEETFSGFAMRVLDIEPGVYHETNETNELNIMANEVKDRFGFSQEEKVVRRSNDSYIYFKPKFRHIKLLLRRRCKLELGTKKNTIFTIILIFILSISLFLARYIAKNIWNREDKLMKVWKLSTADSRYTKVQQEYIKHRVMLIVSIFSGCSMALIPLEAGTAFGFEHVNVKREIAANNYSLASYYLSVLIFEYVRHLPFLIAYMIGMKIIFGEVMDLRSILTSCLIYTVSVVFYLLNGSVSRDSKRSAMIVLSGLTENVIPHYFYLAVCRYVSKYGKWLLIIYFYNLNPNHLLGYCPYVYYLAKFIDDYPEIVDANYTDPPVSSENDYRGLLREYKRLLIGFELPLRWNYIVCGFLLMFYVAFCVLRISFYLRPGYRMRLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT89</accession>
    <name>L7JT89_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">cAMP-dependent protein kinase catalytic subunit (PKA)</fullName>
            <ecNumber evidence="14">2.7.11.1</ecNumber>
            <ecNumber evidence="14">2.7.11.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_2414</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="14"/>
    <dbReference type="EC" id="2.7.11.11" evidence="14"/>
    <dbReference type="EMBL" id="JH994032">
        <property type="protein sequence ID" value="ELQ74663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT89"/>
    <dbReference type="FunCoup" id="L7JT89">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2414"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="L7JT89"/>
    <dbReference type="OMA" id="ELFFCKY"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="7"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ74663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="307" mass="35970" checksum="114427FFAD8E6598" modified="2013-03-06" version="1">MFELSKLKIIRTIGVGTFGRVYLTEYNAKYYALKAVSTSTLLRLKQKDHLNEERKTLCELFFCKYFVKLIFSFKTSRSYFLVLEYVGGGELFYWLRKRGPFKLKDARFYAAEITLALEYLFSKNLLYRDLKPENILLTEKGHIKLVDLGFAKKLNTLTFTLCGTPEYMAPEKLKSEGYGQSSDIWSLGILIYEMLKGIPPFYSKAPYLIYQRILTDVPNYSDMDLIAVDLIEQLLEKDPKRRLSDVNVIKEHPFFGRIFDLIDTIEPPIIPKLNCAGDSQYFIEYNEEKGDEEIEERNKVKMYYSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTC1</accession>
    <name>L7JTC1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">H+-or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994029">
        <property type="protein sequence ID" value="ELQ74703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTC1"/>
    <dbReference type="STRING" id="72359.L7JTC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2367"/>
    <dbReference type="HOGENOM" id="CLU_135788_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTC1"/>
    <dbReference type="OMA" id="CCVITGW"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="6">
        <location>
            <begin position="126"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="21872" checksum="78104796D27F6423" modified="2013-03-06" version="1" fragment="single">VPILYLHRLSLLSLLFHIYLYKTRKKGARNKKMPDATFPIFEIDNLRDIISAVSYIFLVVPALAGAGRGLKESAPGISSAAEIKIEFTSVMAALCFLTTPVIYMLIIFFVFKNKQIASFKDALVKLACCVITGWGCYFTAYTIGSMAKHVLVTKVKEKKFSGQFYLVFVFVEFVGLFALIVSLIFLGEIKEGKSGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTI5</accession>
    <name>L7JTI5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTI5"/>
    <dbReference type="STRING" id="72359.L7JTI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3024"/>
    <dbReference type="HOGENOM" id="CLU_2190376_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTI5"/>
    <dbReference type="OrthoDB" id="2194934at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12744" checksum="D596A8A32BE8513F" modified="2013-03-06" version="1" fragment="single">VSHLITDHKALEVIRNKPEFDNNRPNRWCEAIQQYNFTIEYSKPVNLVEADALSRIHEKVKEPTEVNKKTEKRYETINEKHLCTVDGKNIGGLTLVLLEKSQRKKTRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTQ8</accession>
    <name>L7JTQ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromatin remodeling protein, contains PHD Zn-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTQ8"/>
    <dbReference type="STRING" id="72359.L7JTQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2399"/>
    <dbReference type="HOGENOM" id="CLU_108164_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTQ8"/>
    <dbReference type="OMA" id="KMIACDD"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="169"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="223" mass="25690" checksum="7C643C92E53B7EF0" modified="2013-03-06" version="1">MLRYTHSKTNNYTKRALKLYLSAVSLSFNNFNNFNNFVKIQSLPMLFKESLESLEETPLKVQKTITNIKLLNNQSEDHINTIKQQIELDQCDLQKIVSAFLRLEENEKELNAHLHSLYNFIDGQTETVELDCNNFDEMVSKSALILKTNQISARELGETGAHANKDRDGAPCYCGKDVNAKMIACDDPNCRIEWFHLSCIGISQPPAGKWYCRECRKRQRLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTU3</accession>
    <name>L7JTU3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2571"/>
    <dbReference type="HOGENOM" id="CLU_1435382_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTU3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="189" mass="22491" checksum="CE016E589E978291" modified="2013-03-06" version="1">MEKEELDNIDKYRKGMNVRISNGEDISEKRDAEQELEGQNSFHTLSNEVEKKKRKVIKDKWLCSISSDEHAYLSTKEVLTELLGVSNEKYNKLENFLYYQMDIDLKFSDVKNCDFLKQFDDIAILLVYRKICLSTFKLNDLMDDTENASLMKTYRIKLKDLIHEMYSNGLVYYRMEYEQFLKLVKNNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU03</accession>
    <name>L7JU03_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5094 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2556"/>
    <dbReference type="HOGENOM" id="CLU_1023775_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU03"/>
    <dbReference type="OMA" id="MQVMVGK"/>
    <dbReference type="OrthoDB" id="2187979at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031519">
        <property type="entry name" value="DUF5094"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17015">
        <property type="entry name" value="DUF5094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5094" evidence="2">
        <location>
            <begin position="78"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="252" mass="28511" checksum="49C3BF0F564ABDAF" modified="2013-03-06" version="1">MKTPRKKKVAFYTPSKKKIRCIQQNDEKGIGDTNDGPIRYMDNVPGTDKNAVRTDDGMVRHVGGYTVSGRKNDLVSGRKSDPVGGRKKEAVKKRGGARRGGKAAMKDVHVDHDVDRDESSATSTKENSANTKNSKNVDTRPSHKEILYIENELLQAYREENAFLKTSVSSATSRLTGFTVTEPANDHFIVSYSAYDRHINFRLVKNGRNYEYELIEHRCVELPEFLTDELVFGEEQLPKFFFNVMQVMVGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU51</accession>
    <name>L7JU51_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2806"/>
    <dbReference type="HOGENOM" id="CLU_953725_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU51"/>
    <dbReference type="OMA" id="VLVHYSM"/>
    <dbReference type="OrthoDB" id="10253525at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="292" mass="32717" checksum="8E6D53B57F75E79F" modified="2013-03-06" version="1">MGEKDGDEKEKKELVFNDYEIFVTDFLSKISMISLAVLVCMSIAIVNLISCAQSNDIKNVQFTCNQCFMVLGVITAITLCVMLVAPVIYQSMIYICEGVPDKKMKMKRSVNQIALGLFLLTAVFLMILVPAMFHNNFAKGPVFIFFVLALLVDLVLVHYSMVSEKNSPFRVFITISSVTGIAFLISTFSSIGFSPMVLIVAILAKTAIIESTYFVKQLRTTEDGRKKNVRILNFLIVLAVYSILFYCVFQNDINEYINSVNDNLANYLYGFLHKFVIENPFGIAKIMKGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU57</accession>
    <name>L7JU57_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_2116</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU57"/>
    <dbReference type="FunCoup" id="L7JU57">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2116"/>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_1"/>
    <dbReference type="InParanoid" id="L7JU57"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="38"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="141"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="245"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="474"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ74954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="616" mass="69543" checksum="25088005379C39AC" modified="2013-03-06" version="1">MWELKKDEKSEIIDTLGYHKMQELNKRVENLDVDTPRIYSVSGPVVIGEKMAGCAMFELVKVGTIGILGEIIKIDKDRATIQVYEETSGLRVGDRIEPLHKPLSVELGPGLLENIFDGIQRPLRDIFLEKKEIFIPRGVDVPALDRNKKWHFVPTVKIGDLVEGGDIFGTVDENTLVKHKILVPPDKAGKVSFIVSEGDYTLKDTVMRLITKNGEHMLKMSHEWSVRTPRPVKQKLMADHPLFTGQRILDSLFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDIIVYVGCGERGNEMAEVLMDFPQLKIRGESIMKRTILVANTSNMPVAAREASIYTGITIAEYFRDQGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLAAKLAFFYERAGKCELLGSDKKNGSVTIVGAVSPPGGDFSDPVTAATLAIVQVFWGLDKKLAQRKHFPSINWNLSYSKYIKSLEDYYNKIDTGFVTDRKVCKEILQMDDDLNEIVQLVGRNSLSERDKLTLDVSKLIKEDFLQQNGYSEYDHYSPFLKTRLMLRNIIFYYQNSLRCIQNGILWDKIRKKTNDVFIKLMKMKFEYGDGLEKTLLAVKKQIEDEFKVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU82</accession>
    <name>L7JU82_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U5 snRNP-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2018"/>
    <dbReference type="HOGENOM" id="CLU_415141_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU82"/>
    <dbReference type="OMA" id="YLDHMLW"/>
    <dbReference type="OrthoDB" id="2193278at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="73"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="661" mass="76110" checksum="3D812A9F977966A3" modified="2013-03-06" version="1">MKIPSESSEYDEFGNKIEKEPANSSETTFESISDRIDLLNSDEPVYKELRSKVYEINAFEDEYFDAIAAIPNRILNVVVLGDKSSGKTTFIEHLNLSGACRSVGSARVHTLYEKKFCITTRISPSTNLYADSRGRSKIVTFIDTPGHSDFIKFHRNLFKFTTNFVITVNCTEPFSTYHDYLFRKIGSNIILVITKIDLIIDNGADFMVKRIQYYTRPVISHIFLSSSRFNFITDELDMESVRTLCERYTKGEVQESKEPNFIDKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRKTYLNIPVYVQCEPPSPTQAFQRLPVSVMLKTKQFPVDIAQCIFMNSRIKPVLTAKDQQFVVIEGTGERYLDHMLWELKNIMSVDFTVISVFCTYFESLGQKKERDEEQKSVGLDEEQKSIERDEETSRDLLPRVVFSPNINNKGIILKRIPTYKCFYTRNNNIVFKNSTENEETKNVILEILSRGMLGVAGIVNLTIELSENEDKQIISKELTNSFELYNRIIYVYNYKIQVLLRKKHLDAFEHVARRRKIKKILRSYVEAFDVYLIVGIVNAIESLGLESDISLCAGEKIKVNMMAYKCTRLSEGKTRKVQRLMQEVLNIRGKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU98</accession>
    <name>L7JU98_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Decapping enzyme complex, predicted pyrophosphatase DCP2</fullName>
            <ecNumber evidence="10">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU98"/>
    <dbReference type="STRING" id="72359.L7JU98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2187"/>
    <dbReference type="HOGENOM" id="CLU_008108_5_0_1"/>
    <dbReference type="InParanoid" id="L7JU98"/>
    <dbReference type="OMA" id="PIRLCFQ"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="236" mass="28061" checksum="0FF5281AAEDF0FF9" modified="2013-03-06" version="1">MQYKDVLDELTVRFLMNLPKQDYESVERLFFILEEVHWYYIDFMADDNKTFRTFVIDILSHINYTQVEIDQCLKAFGEYKYDVPVYGALIFNAQMDHILLNKGCSKRAQFLFPRGKKFMNETGAQCAIREVYEEIGYDISDKISKVAIRPSGERYTLYLIFNVPVNTRFECQTRNEIAAIRWVSVRDIMGKGANDLKQVRNVYFKIKDRIDRIRTNRFSFDRKAVLREFDRVITSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUA5</accession>
    <name>L7JUA5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2770"/>
    <dbReference type="HOGENOM" id="CLU_720745_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUA5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="384" mass="45244" checksum="5A9DD67AE64D728B" modified="2013-03-06" version="1" fragment="single">VFIEMPFPKLLFEKIVLLSERSFPVFKFKEICLICKHWYSLWKKKELLAYVLRVYLQNHKDLAFKLKARVEYPQHDSYDQQTKFLSSVIFAENYTEHFIRGVIESGVKFGLINKYTKIIDAYGNLQCRGSICHEIYLDELKIGFLFKYLNISYECLRENDDQLYEIFERKVNKSSIPIRIYEIKNTKQAYINCSWIERKNIQRKIALIRNSSFINSEVVSEIILQLSHWKVSVEQRLFDDIKILKQIEREYCSSSFINSIPKNINIKMHLCSDIIMEEVLKNVIEASYENCLFKNDLVIPDHIRVELIDCRSDNDQFIAFSAGCDDFTVNGGTFKIKSIAMIGLGEVLLHNSFLRFSRKNKFGEGLLELTDIKINRTIRLEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUC2</accession>
    <name>L7JUC2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUC2"/>
    <dbReference type="FunCoup" id="L7JUC2">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2062"/>
    <dbReference type="HOGENOM" id="CLU_118231_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUC2"/>
    <dbReference type="OMA" id="AHVIHPE"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="191" mass="21446" checksum="7C129990D900642A" modified="2013-03-06" version="1" fragment="single">VQSIKEKKVENELGGPLPLLLMDRGTIAKGKELSHEIKERRKEAAAKYSVPIPRIAGLSEVETFNVVTTGKKRGKHWKRMVVKPCFVGDNFTRKTPKYERFIRPMALRFKKAHVTHPELKTTFCLPILGLKTNPHSHLYTSLGVLTKGTIIEVNVSELGIVEQNGRVVWGKYAQVTNNPEYDGCVNAVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUC3</accession>
    <name>L7JUC3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LRR containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993995">
        <property type="protein sequence ID" value="ELQ75078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1983"/>
    <dbReference type="HOGENOM" id="CLU_329604_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUC3"/>
    <dbReference type="OMA" id="MCNITRI"/>
    <dbReference type="OrthoDB" id="10591676at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979035" description="LRR containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="880" mass="102350" checksum="6CD87125D1118F4D" modified="2013-03-06" version="1">MNCMKLYSFVLCFASLIYATESNNVVEIKLDEGYVIEVDTSDKSFESTVLHNSQFLGAIKNNFKNRNVLVVLAFLGLIMGDEHVDLYFSGDKTITFPEESSECNSSCLHLKQKQFYVFGQYVGKYSEIEQVFNNNFSPYYIISGQKFCYIGNLKIHKHTFIDELSNLLFTLYDEIKNSYLVDDNMQNLFVRNKYTNPSEQNVTNPQSISSRLHPNMTDVYEQFFVAFIEKSSLSILLRCSFVFPEVIETYFRIRLQYGKLDATKILQIDLQGYLPNQKSNSRNKTTNNRVKVCITRKWMDSFKRLNNSENIHVLWPMLFSHVRELHLVMKCRYVSFEELLKWRTIIEGKNIGKFVASIFDIHQLPFYYFLEKISLDKSKISVLDLTGCSLCDRDLEVIRDLANLEVLHLPKVIESQNAIVKIFSADSSIGSKLKKLVYDGIIDKSEFYCFEKCPNSLFQTISLDNVEISDRNFQDKDKRFIKRLTFGSDKSMLEFTEHCIEDCITKCPSLNQIVLYNIKQNIGLPNLEVLSFHELTIKFCEMEIDLLTILHFCDSVPIKKVVLEKVIIRYPDDTESISSYNSRKTLQSFSLVESNLLYGRFYDLIKMIRTRKINFVQCNMDMNSLNQAFKSEQMKDLEELEISGNSFSNGYQLDIDNLTNLTSINIINVLRTSKAQKIKYQMCKFSSKRKPRRKKIYCTVLNLSLYPNLTSLVLDIYPKNYSSFKKNLFLAKNLKYLTLHVIAVRIDISKILERNRSIESLCVFGYRKSEMYTTEQEIITSTCKEIALIDIIIKVPTFWKYIANLVQIKTMDIKRLKIETVYENMVSMLYSRISHVRLVIYIKYTAGLVKALNDASNDLKQPNVSFIITDNNVVEPNAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUJ4</accession>
    <name>L7JUJ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2666"/>
    <dbReference type="HOGENOM" id="CLU_2948399_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUJ4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="6905" checksum="9266C67469217581" modified="2013-03-06" version="1" fragment="single">VYFLVFRLLSHHFDTINHVDVLNGVVVINYFNEPTVVETMIGVQHARRGSLGVWVVLRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUM1</accession>
    <name>L7JUM1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUM1"/>
    <dbReference type="FunCoup" id="L7JUM1">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2362"/>
    <dbReference type="HOGENOM" id="CLU_2672863_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUM1"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="75" mass="8591" checksum="FDF64580302EC0F4" modified="2013-03-06" version="1">MIITVKCTDGLGKTVFVKIDDEVMVKDLKKKLGTMINVNDHRISLKKDNFIMRDHVKLSMYQVLDGQAIQICYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUS0</accession>
    <name>L7JUS0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994037">
        <property type="protein sequence ID" value="ELQ74517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2561"/>
    <dbReference type="HOGENOM" id="CLU_3002302_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUS0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6666" checksum="1A8A3C3AFEF98B52" modified="2013-03-06" version="1" fragment="single">VHECQGPIHVDLRSGFVSAISKANSKMWRLNDYEEEFLKGEAIRESPRWHVYTDIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUZ0</accession>
    <name>L7JUZ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1785"/>
    <dbReference type="HOGENOM" id="CLU_1587658_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUZ0"/>
    <dbReference type="OMA" id="IICKFER"/>
    <dbReference type="OrthoDB" id="10384384at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="168" mass="19442" checksum="EF3922DD764D3BDC" modified="2013-03-06" version="1">MKVQLSADQLDDILISLQKQLSPLTRTKLKLFKTLRKIIMANTEIIIPLSEAELADKEEIRDQMVEKLAITRRELPAKCALQVEEHYKRLQEDLKQIIAEDDEETEVEEHVKDVLPADYTCLKEINEGVPNIICKFERAMSVVEEASKNEKEHEVSPEDVAIMYFFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUZ5</accession>
    <name>L7JUZ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993987">
        <property type="protein sequence ID" value="ELQ75130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1931"/>
    <dbReference type="HOGENOM" id="CLU_3385062_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUZ5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="33" mass="3721" checksum="8A831ABCF198ED18" modified="2013-03-06" version="1">MVEKHSCTDKKAVNNFRCINLVGFPYHLGKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVF7</accession>
    <name>L7JVF7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2353"/>
    <dbReference type="HOGENOM" id="CLU_1582460_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVF7"/>
    <dbReference type="OrthoDB" id="10476385at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="169" mass="19537" checksum="942CD790646EA624" modified="2013-03-06" version="1" fragment="single">VQIILNLWLKKGKKEHPQLMQYPHITVLLELLIIFLIPTAFITLVQRKNINDQVLIQKIDSFASAFLAKNSDLMNSGTRAIIITNILSPSNKTEVFTIDTETFKSLEINYMLLKGDELLHQCQKLLTKRSMITNDFDIKHIEKLKENLAHSINRALMKLYSTDRIVVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVH2</accession>
    <name>L7JVH2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVH2"/>
    <dbReference type="STRING" id="72359.L7JVH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2026"/>
    <dbReference type="HOGENOM" id="CLU_040462_3_1_1"/>
    <dbReference type="InParanoid" id="L7JVH2"/>
    <dbReference type="OMA" id="FYIGFVE"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="260" mass="29285" checksum="0C5D153CB5FD135B" modified="2013-03-06" version="1">METHTATLFFLSVFLFFFTLLFSFSYRFFKNLKISSYSKCFAGGIILSTLIFHIFPDVYQSNCGYLGQLFSGISFLILFSIDKLYLYVSDNENDSLPKNVSKAQAFIFIIALSLHSFMEGLGIPAKEGKSLMWYSLGLLGHKWIEAFALSVSVHTSGFETKIVCALLTFYSFLTPLGTLIGMGLIKVLENNKHYDDLTSILNGISCGSFFYIEFIEMLNSEFDKQGMIARRKNGKKVLAIFVGFVLMTSAAIAFHWAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVI1</accession>
    <name>L7JVI1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1533"/>
    <dbReference type="HOGENOM" id="CLU_1385114_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVI1"/>
    <dbReference type="OMA" id="KKAWNIT"/>
    <dbReference type="OrthoDB" id="2188462at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="22494" checksum="5AA46C8BA20F2CEE" modified="2013-03-06" version="1">MQTSIRQIFAPMRKYLSILKVFVSFIFIASMILNNKAVIKIPLKVVPLSSHYLLALGVTQVMLVIALSMCIVVWTISKRVMMCFVVLQYVFVIALGVASSSVVLLTVQMLLMLSLDFIIYRRERKKAWNITLDTSAQIKMVYMKRAIVSNRMVDLNMGELVQFISKEGEFVCVRKFNGEEFTVHENDVVDNIEDVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVJ2</accession>
    <name>L7JVJ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2313"/>
    <dbReference type="HOGENOM" id="CLU_3282353_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVJ2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978793" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4761" checksum="FAB718C8D0AE0335" modified="2013-03-06" version="1" fragment="single">VRTFLFFYVVFMFLDALRNGRIKEELVIYVGELISGGDSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVJ8</accession>
    <name>L7JVJ8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVJ8"/>
    <dbReference type="FunCoup" id="L7JVJ8">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1595"/>
    <dbReference type="HOGENOM" id="CLU_129451_0_1_1"/>
    <dbReference type="InParanoid" id="L7JVJ8"/>
    <dbReference type="OMA" id="RSHWERK"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="104" mass="12123" checksum="65091E63F6A4425D" modified="2013-03-06" version="1" fragment="single">VHKLLIEKKRRNNGRSKKNRGHPGNIRCDNCARMVPKDKCIVKYQVKNLIDAAAADDIRMASVYDTYEVPKTYIKLQYCVSCAVHSRLVRVRSHWERKIRGKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVK9</accession>
    <name>L7JVK9_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993956">
        <property type="protein sequence ID" value="ELQ75464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1584"/>
    <dbReference type="HOGENOM" id="CLU_2211805_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVK9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="107" mass="11968" checksum="C72E827F79696898" modified="2013-03-06" version="1">MEQVKNTLSNKLPLEDDVVERFNKSAAALNERPDLSKVFSSGNKVVKISKKSNVDLLCEDPIKLYAKIEKFFVEKGAERVEQNKAQIEISDGTEANQKTSTANPDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-03-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVL3</accession>
    <name>L7JVL3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993954">
        <property type="protein sequence ID" value="ELQ75469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1573"/>
    <dbReference type="HOGENOM" id="CLU_1187495_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVL3"/>
    <dbReference type="OMA" id="ERICHID"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="234" mass="27155" checksum="27C81523F7B9C922" modified="2013-03-06" version="1" fragment="single">EHLLLIISLCLATDTKESKDGVRVLSKEEDKWLIGMCKKRTEHVKVLFDTISKHIEKVEKEGRKDESEASKQEYEQALLNFKSETKRYSEKIRNMIDVLCVKKEIGFDTTELLYKSTIAYVSTMEMLKKVLDKKTPLEDKFAEEYDKSVKALNEKPDFSELFTDDVKAVRMSQDSNIELLFKDFENELANEMVKWFPEEKAKDCVDQVKEKLTELTTNTNTDDNQTNSAANPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVQ3</accession>
    <name>L7JVQ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994018">
        <property type="protein sequence ID" value="ELQ74822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVQ3"/>
    <dbReference type="FunCoup" id="L7JVQ3">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2241"/>
    <dbReference type="HOGENOM" id="CLU_018687_0_1_1"/>
    <dbReference type="InParanoid" id="L7JVQ3"/>
    <dbReference type="OMA" id="WLNSPMW"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="100"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="390" mass="45557" checksum="B895AFD0F663C0B6" modified="2013-03-06" version="1" fragment="single">VMENRTVMKNKDNMIEENSVNMNNNNENSVTNTNSTNTNTNPTNTNTNPTNSTNTTANTTNYIEERIEYKIYSHISEQLDISNFVPRNYYELRNYCYYGYSNALLRPKFWKLLLGYLPKNKFKTEYHLKERRKLYHFYYEKANAVLMDNPGIDDAINKDVDRVCILPVTVGVHDGSIAQKCSFLDSCADRMHRNALKRILLTFKVTNSSVGYTQGMHMVLIPIYYVFSTSKDIDDVRYAEEDAFFCFFNLMSEIGEHFISEYDYDCTVGIRKKMDSVLELVRRYDAELYAVMERKKISETMFHLRWVSLLLCSEFEIEQVLVLWDKLFADSYRFEMVIYCCAAIIVLMKNAIVESGFDECMGVLQATKKDDVLTVFALADKMRREYNGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVV4</accession>
    <name>L7JVV4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1492"/>
    <dbReference type="HOGENOM" id="CLU_3401324_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVV4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="31" mass="3657" checksum="81507A22B6D6A383" modified="2013-03-06" version="1" fragment="single">VLRNILGVAEDRMDVESVYAYFKGKYERYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVZ2</accession>
    <name>L7JVZ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993984">
        <property type="protein sequence ID" value="ELQ75186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1870"/>
    <dbReference type="HOGENOM" id="CLU_2365433_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVZ2"/>
    <dbReference type="OrthoDB" id="3269595at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="96" mass="11003" checksum="E652905449964938" modified="2013-03-06" version="1" fragment="single">GMRPFLTRKFVPAPIKMLLVKSVLLSIATYGCELYGMSTVRLAPLQRVIDHALKEVLSFGSSYCRKAAYKELRIDCVVIRAAKLRTRAFLKWKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW07</accession>
    <name>L7JW07_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2131"/>
    <dbReference type="HOGENOM" id="CLU_425253_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW07"/>
    <dbReference type="OMA" id="NINVERR"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978902" evidence="2">
        <location>
            <begin position="23"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="644" mass="75711" checksum="4EFD78DD2FEBDE11" modified="2013-03-06" version="1">MFRRYSFLFCLSLIAKLQTAQRDTTDQNEGKLAGDDDVSTDITFCYEYYTRCSQINQTGRKSTNTCEYEKVRLDMEQCSTHVPNDQPSSTSYAVSIIEPYLSPSHDSIRCDLFSNSRGAETSEVLRKNEIGSNKSRNDIVPQERISYEETVLRSQRIKTSDQSTLKTALPNDIKFGDIRSIGSEYRNSASRLKLFKHLYYNVLQSTWHVIYGYYESGASNSSRFYIQHDRELFFMKSWLYLSNSKRMLGKQIFSSIRIICQRHEKHMVKNSSTIRRYDKIWRSSNPSIVIRRCNRNYVLNHKNVLWMKKQNKAYFDKHTRMYKMRKCDKKYDLMPYFNELHNIFEEEGGLNAVSVRGIMHYLLSNANRLFRIIAINPAGFVTIVKLNIEKIVANQLQILLNSRLSTKLLLFPELLSFRQYSYNINVERRRMGVHKLYISYYVMCKFEVLVQFFEKTLEQKGWSKKSAREPDMLFYTMYTREFFLIYIFNNIFLVKLPCIITYISLCRMQFVLFFNFSQEDSCKLTGDFVEFLLLNFVDVLSFFDSESFVKFCANIPELDAETVIHVAIYQLILKHICCSQKALQKLVKRFLVCIKALTPSALYGSLCKTILDDLCDERFSLHNHSAISNWIDHVNSLVLQSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW43</accession>
    <name>L7JW43_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993946">
        <property type="protein sequence ID" value="ELQ75540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1506"/>
    <dbReference type="HOGENOM" id="CLU_2929228_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW43"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="6885" checksum="7E8565FCBB164108" modified="2013-03-06" version="1" fragment="single">VADKMRKESRVIPWKKGMGEKNRSVAESATKKDSINGDARKIGEKIKGIPNIYIRSIKEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWA8</accession>
    <name>L7JWA8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1468"/>
    <dbReference type="HOGENOM" id="CLU_1614891_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWA8"/>
    <dbReference type="OMA" id="LINIQCH"/>
    <dbReference type="OrthoDB" id="10513848at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="165" mass="18653" checksum="625B7AEDCC8675D9" modified="2013-03-06" version="1" fragment="single">VFSNPCGCTIETVGNIKIKLPSSIENTILKRLNVPMDHLLVVNENFQNVAIIFSKGSFDLSKIKKLEGLKLIIGKKGLINIQCHDLSNVITLEVSFDRNEKYFNLLLSKCINAKKLVLYSTVCELHGWIQNESSLGYKEEMASCELTESKSITRPENHFYLCRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWB8</accession>
    <name>L7JWB8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1371"/>
    <dbReference type="HOGENOM" id="CLU_2929227_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWB8"/>
    <dbReference type="OrthoDB" id="10375583at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="7185" checksum="B0A2B5010AE7CBAA" modified="2013-03-06" version="1" fragment="single">VLLCKEKSFEFLQRSGVVKENVPFLRVEGEEVSLPFSFKFIEAYDDTPYLAIVMKLRERKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWD4</accession>
    <name>L7JWD4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWD4"/>
    <dbReference type="FunCoup" id="L7JWD4">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1658"/>
    <dbReference type="HOGENOM" id="CLU_034027_3_3_1"/>
    <dbReference type="InParanoid" id="L7JWD4"/>
    <dbReference type="OMA" id="FGFSVYH"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="202" mass="23317" checksum="5B6A9D13BE81A100" modified="2013-03-06" version="1">MTNTSSSSASFTNTDSLSDSDDTWITRFHSRAENSGLIVIHDSFLQDKFNLVGLMRYIANLSRSFDVIKNKMPSRNKKEETLLYYLVHQRYILTNTGMEKMLERVIQHFYGDCRRMGCEDIPLIPLGLSNNPKISSVKLYCYNCNNVFDPDNSLSELDGCSFGSSFAHLLILTHKENFQKKKYGSYIPRIFGFRIYEEKDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWD7</accession>
    <name>L7JWD7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1401"/>
    <dbReference type="HOGENOM" id="CLU_1448761_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWD7"/>
    <dbReference type="OMA" id="NYMRFAK"/>
    <dbReference type="OrthoDB" id="10374725at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="187" mass="21763" checksum="558A5F1A5C5C04E5" modified="2013-03-06" version="1">MIGIKLKWIVLSFFIFLFAVFTPLLLLTLYIKSKRIDRAFTNAIKDIPATEQTLNHLLVKDTKLYVLESVQDSEIDKIDLSILSNENILVYDHLKLEKACNSFLNSIFGEFGLKIFYRKSLVIKFVRLVNYMRFAKFVKNSLVLITIKGTKLEITAKSNDKFKKHEISFDKSDEPMLICKYIINVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWG0</accession>
    <name>L7JWG0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWG0"/>
    <dbReference type="STRING" id="72359.L7JWG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1277"/>
    <dbReference type="HOGENOM" id="CLU_043966_5_1_1"/>
    <dbReference type="InParanoid" id="L7JWG0"/>
    <dbReference type="OMA" id="KSDMKFV"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="7">
        <location>
            <begin position="11"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="187" mass="21462" checksum="6924001E92000323" modified="2013-03-06" version="1">MDRTPLLSKNDLNVLVCYTKTKRIIGYQGTIPWMGRLKSDMKFVSKLTTTGNVALVMGRKTYESIGRPLPKRVNIVLSTTMEDQNGIVVKKSFDEAINFCREKEYVTVVFGGEEVYRVALKRRCRIWATVIDDMDFCGDTFFPEVDCKYECVNEDVMPIIGECEGVEYNGQEFIENGIKYSFYTGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWH2</accession>
    <name>L7JWH2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4 10"/>
    <dbReference type="EMBL" id="JH993989">
        <property type="protein sequence ID" value="ELQ75097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWH2"/>
    <dbReference type="FunCoup" id="L7JWH2">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1962"/>
    <dbReference type="HOGENOM" id="CLU_025427_2_0_1"/>
    <dbReference type="InParanoid" id="L7JWH2"/>
    <dbReference type="OMA" id="CAGPEVE"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="216" mass="25207" checksum="47BC282F7F96179A" modified="2013-03-06" version="1">MPMKLKDLYDVPLKHKKVVLYADFNVPIVEGEIADTFRIEKTLPTIIYVLSQEPDLLVIMTHLGRPDIHEKKCFVEGKGKLANTLLPVYTWLSQRINIEFVRDLDNLYEKKGTVLLENTRLYEKAYIINRLYFIDLVIFDGFGVAHRPLIIPKNKKVYAGLLMRAELERRLDNFDLVIMGGRKITDKMALIKHLKFKNIFFGGGMCFSILKQKKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWJ1</accession>
    <name>L7JWJ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1250"/>
    <dbReference type="HOGENOM" id="CLU_1975914_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWJ1"/>
    <dbReference type="OrthoDB" id="10503252at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="127" mass="14680" checksum="3D5F2FEC1E4E30B6" modified="2013-03-06" version="1" fragment="single">VKKKKLAETLIYRPRKSFIGKMQNKIILRDTLWSKQMGGNHKHKSVVNTGSVTRKETVLVNLYYLTEKIRDVLKIRKLFSVVKLYSRKDGIILRAGDVVVKVKVSRCVDEYCGLLCRGLAMAERKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWJ7</accession>
    <name>L7JWJ7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1332</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWJ7"/>
    <dbReference type="FunCoup" id="L7JWJ7">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1332"/>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_1"/>
    <dbReference type="InParanoid" id="L7JWJ7"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="49"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="475" mass="52539" checksum="B0604B2E21ABABA9" modified="2013-03-06" version="1" fragment="single">VYINYPQTICSRARICVVYCFSSFHKNFTLHRHMHDAPSTPHEHTIMNQATINIGTIGHVAHGKSTIVRAISGIHTIRFRSELERNITIKLGYANAKIYKCDTCPRPDCYSAMNSSSPFTISCPNNSCEGTSTLIKHVSFVDCPGHDVLMATMLNGTAIMDAAMLLVAANEPCPQPQTQEHLFAVEIMNLKKFIIVQNKIDLVSREQALEQKDQIVAFIKNTKAENSPIVPASGQLNINVCAILDFIVNYFPEPERSKEHDVRMVIIRSFDVNKPGCGIDGLKGGVIGGSLLKGELHVNDEIEIRPGIIYRKGSKVECKPFITRVTSLQAEKNLLSTAQPGGLIGVGTLLDPFFCRADKLVGQVMGRRGELPDIFVEILVFYSLFQKISGVDKRADKRGLMTLNEQILVNIGSTTTGSTIMKLENDKVRLSLVKPACCEKGERVSISKKIHGHWRLIGYGVVLEGITIMPVYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWP3</accession>
    <name>L7JWP3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1382"/>
    <dbReference type="HOGENOM" id="CLU_1856802_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWP3"/>
    <dbReference type="OMA" id="WFFICHA"/>
    <dbReference type="OrthoDB" id="10438376at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18211" checksum="DBBBA8C7B74F72E9" modified="2013-03-06" version="1">MENYQNYYVITGEQRSWVWYTTIHGAKVVLLAFFFYNAFSEFCGELTILRAICITLASSNMFGWFFICHALMSKNIYQMKIFNYILTLELILLITLVMEALGRIHHVGALAIFPIAIIIGLEMIYNCLVIKAAAPEFSWYYFKKTRMSPNLLGKSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWQ6</accession>
    <name>L7JWQ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SMT3/SUMO-activating complex, AOS1/RAD31 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWQ6"/>
    <dbReference type="STRING" id="72359.L7JWQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1882"/>
    <dbReference type="HOGENOM" id="CLU_081901_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWQ6"/>
    <dbReference type="OMA" id="NCVETEH"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="187" mass="21663" checksum="209BA9ACDA5AC610" modified="2013-03-06" version="1">MECPDMSLHYEKKYDRQIRIFGFTTQEKLQNMCVTLYTSTFNYISAEIIKNLVLLGVTNLKINKRAEESVLRMIPGGLQAINDKLRLVVFDDIVDVIDYSKTEDNVADEHAESLDIIIAVDYFVQNERRNSFYVCSKCYMFSDNCDHNCVETEHSIENECLLGAILVQEIVKMVSNESCQKMYRLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWT2</accession>
    <name>L7JWT2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1909"/>
    <dbReference type="HOGENOM" id="CLU_1327276_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWT2"/>
    <dbReference type="OMA" id="FKECPFC"/>
    <dbReference type="OrthoDB" id="10310232at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="24565" checksum="95A9A49C8FA0DE1E" modified="2013-03-06" version="1">MLRNYLKNKRVLLKLSYLLQYPQSNYSFAITDFDKRLVKYARKKYEEFKNRQIRTIRTTRHENKDEVALSDFNDFILMQPTNERIYKCLRPDDLVMEWLLERYDKGGFKECPFCSKKIDVNSFERHVKEEINPEGDGQGVSKIRVLVEFECDKKVLTITSRNVKEAKKEISAELKLPVSKLHLFDGKRALKNTDDICGSELTLRMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWW0</accession>
    <name>L7JWW0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993903">
        <property type="protein sequence ID" value="ELQ75919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1117"/>
    <dbReference type="HOGENOM" id="CLU_3210265_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWW0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="45" mass="5383" checksum="AEB217EAD07C5179" modified="2013-03-06" version="1" fragment="single">VFKVFYRKLYENGGKRFLWNDYGASLYINGILISLWLYGIVKHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX79</accession>
    <name>L7JX79_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PP-loop superfamily ATPase-like protein</fullName>
            <ecNumber evidence="4">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="4"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX79"/>
    <dbReference type="FunCoup" id="L7JX79">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1033"/>
    <dbReference type="HOGENOM" id="CLU_026481_1_1_1"/>
    <dbReference type="InParanoid" id="L7JX79"/>
    <dbReference type="OMA" id="KPVRGIC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103016">
        <property type="term" value="F:tRNA-uridine 2-sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="285" mass="32418" checksum="2978D5C494A7C429" modified="2013-03-06" version="1" fragment="single">VQNDLFSRGEKVLVAVSGGKDSTVLAHIMDLLNKRHDYGINLHLVCVDEGIKGYRDHSLEMVKQNKKEYNLELEIVSFKEMFELTMDEVMQKKRVGSCTYCGVFRRQALEEGARRIGATKIITGHNADDMAETVVLNLLRGDFNRLKRCTAARTKKNLSDEPNIEDMKKGCGCDESVYSASLVRVKPFKYIYEKEIVFYAYLKNLKYFSTECIYSPGAHREYARMFLRSVEPELIMNVIKSGEFLERSDAGARVWRCVSCGKMTSSAAKRCKACVLLSSLQNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXE1</accession>
    <name>L7JXE1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitogen-activated protein kinase kinase kinase, non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXE1"/>
    <dbReference type="STRING" id="72359.L7JXE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0934"/>
    <dbReference type="HOGENOM" id="CLU_065009_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXE1"/>
    <dbReference type="OMA" id="IMGQTEN"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF4">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="360" mass="42137" checksum="1F4FC5E46EB1B491" modified="2013-03-06" version="1">MSIPNEQKILHYIDVESDRALSYENRTDQNKYFASLRPALPLKPIKMTLQTTVFLYKREGGEESSEHGDRTGGHANDGDARESFAAQRYFVIKRAIIRKDTNTQEDTISMRLRHPNLLTTYKTFRTEFVDRNNERQDIVWLYSQFLKHRISHKYVAMDENIIRHILTDVLHGLRYMHERKIMHLDIKIANIMGQTENNRIVYKLIDFGYARDLTLTDKGNKLEEIKIPSKSYGTFPYKPPEVVFENVHGLKSDIWCVGAVAWFLSLGRVPFYHDNGEKNTVTYRRFIKGTKKHFFYPETSNELRDFVLVSMNRRRANRPSVKELLKHPFILGTKFEESESEHDSGFGSDSGVESYKDNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXF3</accession>
    <name>L7JXF3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993874">
        <property type="protein sequence ID" value="ELQ76109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0923"/>
    <dbReference type="HOGENOM" id="CLU_2160176_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXF3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="111" mass="13065" checksum="4E26F51571CC1306" modified="2013-03-06" version="1">MNITYQSCTIQLPGMPTESARDLYYLKLDLRRRPPLTSTTNIFSFFVCEVLILQFFDLFHSKNKFIEEYLLISEVEYHCLIILNAKFLCIAFDVVNNSHELLFLYFTGYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXM2</accession>
    <name>L7JXM2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1548"/>
    <dbReference type="HOGENOM" id="CLU_3191631_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXM2"/>
    <dbReference type="OrthoDB" id="10435107at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5160" checksum="C50A3752D64C18FD" modified="2013-03-06" version="1">MRMTVSDFVFAGDGDEAMVWVEYWRCVDGGTVGKRLEYLKGVVKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXQ0</accession>
    <name>L7JXQ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA helicase PIF1/RRM3</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXQ0"/>
    <dbReference type="STRING" id="72359.L7JXQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1203"/>
    <dbReference type="HOGENOM" id="CLU_001324_4_1_1"/>
    <dbReference type="InParanoid" id="L7JXQ0"/>
    <dbReference type="OMA" id="IISRINM"/>
    <dbReference type="OrthoDB" id="3353471at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF48">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="17679" checksum="E27BC06ACF864E05" modified="2013-03-06" version="1">MPPHKLVLKRGALIMLLRNLDPANGLLNGTRLIVDELHNNFIIATIVTGSEKDNRVIISRINMAQSEAQFPFILKRRQFPVLLSFAMTIHKSQGQSFDKVGVYLHSPVFVHGQLYVALFRVRDASGLKVYIADNGDQGKADNNMVYTKNVVYNELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXW8</accession>
    <name>L7JXW8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXW8"/>
    <dbReference type="STRING" id="72359.L7JXW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1460"/>
    <dbReference type="HOGENOM" id="CLU_2943459_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXW8"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="7105" checksum="6F6D4FA8F63B664A" modified="2013-03-06" version="1">MNAIRDVFTHAYRIMSSVAKERVGDKYIALPLWIKVSDAEITWRENVTKFYKKVVIDKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXY6</accession>
    <name>L7JXY6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993867">
        <property type="protein sequence ID" value="ELQ76155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0871"/>
    <dbReference type="HOGENOM" id="CLU_1334752_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXY6"/>
    <dbReference type="OMA" id="ICLADSW"/>
    <dbReference type="OrthoDB" id="2195370at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="206" mass="24233" checksum="76968D4AAB7CF439" modified="2013-03-06" version="1" fragment="single">VRISTPSMTLHSKFKDFGEDFDLTTYINKKGYPDDISVLKAARNDLLGKRKDLEISILEEFIQNEDHFMNVLDNYSKVVKLKKEIKDNLASYKKLIMSLKERETITFVDDRKRDELQQKFTKFEDDMSLFLTEKRYLVDCVEVSVEHNNAERNGMVLLTNDFLFVGIKNVNKYKLLNVFSYDLVQMKMENDYLVVKVDPICLADSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY06</accession>
    <name>L7JY06_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0867"/>
    <dbReference type="HOGENOM" id="CLU_1300460_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY06"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979120" evidence="1">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="212" mass="24427" checksum="94E087780007CA1D" modified="2013-03-06" version="1">MVREKRCYPPMLLLLSILAFIEGSSRNTQEPHNEGIAMHPSIEPELMAYAHMYDGFIIRTRISLRKYRHCDIQNYANALILLADLCDLKIREAKIMPVRKNTIIVIYNDMVTKIQRDIGLSLREASLIAFINITFLCFKEFYRCLVISLVNSSGKPINAIHQALRWYGKSLTKFLCYGTVDSVAFLEMVRSLHIFYDVVMNNMNSLLLVGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY44</accession>
    <name>L7JY44_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY44"/>
    <dbReference type="STRING" id="72359.L7JY44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0826"/>
    <dbReference type="HOGENOM" id="CLU_065681_4_2_1"/>
    <dbReference type="InParanoid" id="L7JY44"/>
    <dbReference type="OMA" id="CEDKGFE"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="190" mass="22885" checksum="F9F5310CFDF68EBA" modified="2013-03-06" version="1">MLFYDHFCAFKRTKYSNFAMEEKKKWSDEVEELLSEQLRIENFAFYFYQSAYQYCNSREMALPSIANFFYKQYNEELTHAKGIIDYMNQTGLRPKFKELSLERTNYKSLVEVFELSLKYEEESYKHILQTYKAADKHHDYALCQFMDDYVAEQVKSIKEFSDYLQNAKRCAEGFATFNLDAEFKSLTKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYF8</accession>
    <name>L7JYF8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0657"/>
    <dbReference type="HOGENOM" id="CLU_837287_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYF8"/>
    <dbReference type="OMA" id="FVLMNSC"/>
    <dbReference type="OrthoDB" id="10373116at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="317" mass="37004" checksum="63B74C380AA9DA5F" modified="2013-03-06" version="1">MNKWNKNAEKSLINNKTRPYVLSLWNTSHSPRSYDHKSSKGTGAPRLIFFIIAAGIGSIFLVSFIFNWFIFGKLNRNFTKKMQTNEIKSIKRDFIPDNALSSFVLMNSCVVNGENCLSVFPLLNDVHLVLEKDTILGPEVDDRLYYRKNYFETMMTYYKEKSKLRYIPVSNVKTRSIFEMGWFTKTFRNTKKNRYSLLTAANNFVDTVLHKSTFCQPDETFLFAVLSRYYIDVIKYNFTGERFVFDRSFSFYFERGLASESFSYIVDALSKKLSGQQIDNLIQTIDNEDKKIKMCLNEIDNNLHINIPERVQGNTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYI6</accession>
    <name>L7JYI6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993844">
        <property type="protein sequence ID" value="ELQ76528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0488"/>
    <dbReference type="HOGENOM" id="CLU_1251507_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYI6"/>
    <dbReference type="OMA" id="HTEYESI"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978995" evidence="1">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="221" mass="25752" checksum="3B7A90C7CB8D50BA" modified="2013-03-06" version="1">MLLLLFFLTTKLQSLKSVCHGTPYTVYNFTKLHTEYESIFSGELTRLSCDLKEIVAATSENAQYMNSSISTSFFKYLTASTNLKGQREESFDSVKNMVLKAICELKILADFEVLPCHRENAKEWLAAIYELLHSTMEMIVRSKPKHTDSCSVVLPNLKKYFNNKEKIASDLELWAEDKIILKEEIKEFVEKLPSRMTVLFDELRNCLGEKRNFFEKMFYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYN1</accession>
    <name>L7JYN1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="JH993840">
        <property type="protein sequence ID" value="ELQ76539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYN1"/>
    <dbReference type="STRING" id="72359.L7JYN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0476"/>
    <dbReference type="HOGENOM" id="CLU_034585_4_1_1"/>
    <dbReference type="InParanoid" id="L7JYN1"/>
    <dbReference type="OMA" id="VYPAPWI"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="9">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="238" mass="28255" checksum="3E2E5155F66809B2" modified="2013-03-06" version="1" fragment="single">VRIYCDGVYDLFHYGHMRSLMQAKHLFPNVYLLVGVTNDCTTLQNKGSLVFNEHERTESVRHCRYVDEVIQDAPWSITDAFIEAHRIDYVCHDNVPYSCAHTADVYDSLKRANKFIPTRRTLGISTTNIITKIVKDYDLFVRRQLERGINADELNLSFFKKESIYVKNTIKNIETDLMNEIREIRDELRIALLYWERVSNEMVSTFSHRFVRTVNEHSLFKRIFRKIVLMIERKRGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYQ5</accession>
    <name>L7JYQ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993908">
        <property type="protein sequence ID" value="ELQ75882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1159"/>
    <dbReference type="HOGENOM" id="CLU_2456346_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYQ5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="10351" checksum="1A5BC7445AC73818" modified="2013-03-06" version="1">MKCQPRNVRRSRLSHTDRSVMSRFKQVNLINLPLSFWKFVVVNPAIYSGWAALIKMCIVAVMYAYRLTGYGAITPVYEEKCLFCGKEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYS6</accession>
    <name>L7JYS6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0334"/>
    <dbReference type="HOGENOM" id="CLU_472658_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYS6"/>
    <dbReference type="OMA" id="DARIMRK"/>
    <dbReference type="OrthoDB" id="2190535at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="68985" checksum="79081DF2242F1E3A" modified="2013-03-06" version="1">MMNLVYWPSLNIFLTNMFTNKPTMRYASILEIASNISLLNHDKLYIKKIIELIEMYINEVQYVDLESFVQNERKCRELISLLCVIFSPIKGLKLYKRYKNVYKKYMLKNIEELQNEILVKNSTIDEETIHVLKRYKVYNVVFRHVKKNIINNYFLEISKASDKKEELSMIFRILERESKGILDFKTIETCFLDLYLNKFENIYEISMTEKFPDLFNLFVRANQYNLFTRKFEECLNNNFSFEYMLHVNLFGNILGKFKQFLNRNEDIFIRNVYRLQSQPKKNLNFILESLNQIDTFEKTYRTYLANKILKREDVSEECDVMLEKNQENRRVTVTEITENVDTNMDENIPLEVFDIAGRGKMVMRNKIFRKSLQMIQNSEKPVLDFRWPKYEELTFSVPPEISCDFAYNKTLSTLKIRIEGFVVICTLFQYKMIKYVIDNYGNKNIIYKKIRKTKFMCIEDKRDFFKSFLKNKTEHDVFYDHIDPICSIMSDNLSFLITRDSNLCPDFRLLRDKTSSIAQNDDYKIDARIMRKLKRIKKCKLSDLYDEGGRIKVSDRVAALEQKGYCTRSGDTVNYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYS9</accession>
    <name>L7JYS9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0304"/>
    <dbReference type="HOGENOM" id="CLU_1644904_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYS9"/>
    <dbReference type="OMA" id="LQYHERS"/>
    <dbReference type="OrthoDB" id="2190737at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="18777" checksum="822FE643434E139F" modified="2013-03-06" version="1">MENLKEEEIAILQNIFRTDLSVEKNTLRITTIFGVLNFVLDSSYPDTSPILDVYYENKKSAEQVVNYLTERSRMHQGRPMLYPLVIDFLQYHERSREQGAKDIGGSVEMSYEIVDKTDQRVTEQEFYSWVNSNRPASVVQTGISGKEFFLRMKGNYQEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYU1</accession>
    <name>L7JYU1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993902">
        <property type="protein sequence ID" value="ELQ75922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1109"/>
    <dbReference type="HOGENOM" id="CLU_1994209_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYU1"/>
    <dbReference type="OMA" id="VYCIADE"/>
    <dbReference type="OrthoDB" id="114080at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="125" mass="14586" checksum="9F723BC143C7FC61" modified="2013-03-06" version="1">MVNLHVELENEYKLLKQLLYKSKNQHRRTLIYKKMKELFKKIKKRESMCVIKNVARGLYVLSSSNIVMGHFVGFTYVIMGISAKVYCIADELEIDEIKEKRTNKSDSDEMGNLFGNTGKDDFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYX9</accession>
    <name>L7JYX9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA repair protein RAD18 (SMC family protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_0490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993844">
        <property type="protein sequence ID" value="ELQ76530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYX9"/>
    <dbReference type="STRING" id="72359.L7JYX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0490"/>
    <dbReference type="HOGENOM" id="CLU_471872_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYX9"/>
    <dbReference type="OMA" id="NERIELH"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="247"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ76530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="578" mass="67248" checksum="A915D5D6AE32C2D8" modified="2013-03-06" version="1">MVKGNIIKSITLSNFMCHTNLRLPFISPITVIGGFNGSGKSAIMIAIGIVLGQRTNALDRGSSAKSLIQNGKSSAKIQLELSNVQHRFNYGFFGNSIILERVIKRDAAHSIRIKNDSGKIFSTKKEDLDYIIDYFQLHIDNPLNFLTQENSKKFLKITKAEDLYSLFLRGTELDDVAELHDEANKKTTEMKTRLELLNEELLEIDARRKKKKSDLDIVVDGSKIDEKIAQLKNEIEWSRLKESLLEIRARKEEMDVLSREVKELDNKINQNHLMINEMKKEEQEKECEVKRIRAEISERKKILEEAVKNYELEEREMKNDLEELTINYNEKKQRLQNLNRLGGIDKLAEKKALLEQKLGMEEKYSAQLETLSQKMAEENERSSSNKAKLVQHRQTESNISKQIEFLKKIEKNKLLFFHTKINDILREIRSCKFNDDVIGPIGSYITLKDFKWNKAISIILKNTLSNFIAFCKEDKIKLKRIFNKYDANFTILVPSSRSDAPINYEKRTGHNFAIDVIEVNHPRKNVILNQLIIMNSLENIILVEDRSFAYSILKKKLWDDIDIRSRPHIQKTAIKYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYY5</accession>
    <name>L7JYY5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JH993894">
        <property type="protein sequence ID" value="ELQ75972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYY5"/>
    <dbReference type="STRING" id="72359.L7JYY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1058"/>
    <dbReference type="HOGENOM" id="CLU_1504496_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYY5"/>
    <dbReference type="OMA" id="CNHIEIG"/>
    <dbReference type="OrthoDB" id="2195025at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="179" mass="21055" checksum="8D329416ACB870AB" modified="2013-03-06" version="1">MNKLKLQNTVFPVANAHIKERRLAKLIGKNYNLRSRIYNEKRGTIKLEDCIDLFLSKEYLGLDNRLVCTYCERVTVHSKKYEIVFLPKYLIIQLKRFNFNGDYQRKIKTFVDYHSTLIINAVRYTLRSTCNHIEIGVGSGHYTAYFYGDRIVCANDSVVSEVKDVNKSNAYMLFYERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYY9</accession>
    <name>L7JYY9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0761"/>
    <dbReference type="HOGENOM" id="CLU_1171379_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYY9"/>
    <dbReference type="OMA" id="ALSICEY"/>
    <dbReference type="OrthoDB" id="10388253at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="22707" checksum="B9C1FEFA8CCD061A" modified="2013-03-06" version="1">MYYRFLIPGLLLFALSICEYYNRTSLSYPIGGRISRTVGQMDIFIMFGSLLSILAVPVIVYFLYNFQYYNLGTAPSYLLSYGVLALSFINGYYLSYYYGTYKQNMNKFSYITPLRYALFILLFTPVISEYFCGAKYFCAFPITLMYVIGVFTKSFTRNYKKPVNIFFFVFGIVALIYLGMNMQNLITNVSVNSNVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYZ2</accession>
    <name>L7JYZ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993893">
        <property type="protein sequence ID" value="ELQ75982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1057"/>
    <dbReference type="HOGENOM" id="CLU_1416093_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYZ2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="192" mass="22571" checksum="1AA6A32076107175" modified="2013-03-06" version="1">MYILCGGKVKNEKTSQKPGSEKCVNVSKEIIHENNNEDEYYNYVRLINTEFNEISKTVRAFMDPVRILRTVEDMQVDFDTFKNTMIPTSYMVLMLCTISLREYLSNIAERRLWKMNGRKPASSGATWIAFNIRFKILTQFLNKYKNVEGYGRSGHDSTIREHSCRINRNLYYKLVSFVNKYEDLLKKCSPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYZ4</accession>
    <name>L7JYZ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA repair protein, Swi5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYZ4"/>
    <dbReference type="STRING" id="72359.L7JYZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0377"/>
    <dbReference type="HOGENOM" id="CLU_166973_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYZ4"/>
    <dbReference type="OMA" id="DYYYAVP"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="13101" checksum="E0C884DB107834AD" modified="2013-03-06" version="1">MISELNNWQKNKIIHKSKITAFDFLLENHLIKHIDMDYYYAVPDIENQFYKVKCESMNMPDDVEAVVKNFIRKLNTYNELKDCCESLVGKIAELRGVRIKDVREEFELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ52</accession>
    <name>L7JZ52_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ52"/>
    <dbReference type="STRING" id="72359.L7JZ52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0403"/>
    <dbReference type="HOGENOM" id="CLU_071116_4_0_1"/>
    <dbReference type="InParanoid" id="L7JZ52"/>
    <dbReference type="OMA" id="ANYTCPK"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="5">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="113" mass="13173" checksum="0194802F53A6FBE6" modified="2013-03-06" version="1">MVKTAAKKPKKLIFKNTKKSYITKDNKTRGIKFLMKKLKENEPEFFTLINRVSVRPKMKLCDITGLPANYTCPKTRLNYFDKDVYYHLLDMNTDTLKSILAIKNFGANLSTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ55</accession>
    <name>L7JZ55_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993826">
        <property type="protein sequence ID" value="ELQ76728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ55"/>
    <dbReference type="FunCoup" id="L7JZ55">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0282"/>
    <dbReference type="HOGENOM" id="CLU_056222_1_0_1"/>
    <dbReference type="InParanoid" id="L7JZ55"/>
    <dbReference type="OMA" id="CQIASAH"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="286" mass="33239" checksum="B5D6A5111692D29C" modified="2013-03-06" version="1">MTNIKLRKGYLHRFQTKKRRRRENKTDYTHRRNMLRPNLKNYGALKSRLVVRRTNRKIICQIVKAYADGDRVVVEATSDELRQYGLCVGLTNYSAAYATGLLVARKALVRMELGGVYGAKQVDGKIEEQEDVDDERRAYQVFLDIGLGRSTRGSRYFAAMKGASDGGLKIPHSEKVFPGYKKDEDFDAQVLRDRIYGKAVKDYMIMLRENDNEKYQRMFSEYIKNGIAPEDLEGMYEKVFENVRAVKEIVVKERKDYSANKKYRKEKMSGEEKKKRALEKVKQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ66</accession>
    <name>L7JZ66_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0420"/>
    <dbReference type="HOGENOM" id="CLU_3416413_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ66"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="27" mass="2830" checksum="8FC73FFCF54068EE" modified="2013-03-06" version="1" fragment="single">VRGGALILSRNQMSVAMVGPSEPEECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ81</accession>
    <name>L7JZ81_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ypt/Rab-specific GTPase-activating protein GYP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ81"/>
    <dbReference type="STRING" id="72359.L7JZ81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0346"/>
    <dbReference type="HOGENOM" id="CLU_018687_5_0_1"/>
    <dbReference type="InParanoid" id="L7JZ81"/>
    <dbReference type="OMA" id="CLFVREF"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="233" mass="27703" checksum="7638A46592B145E4" modified="2013-03-06" version="1" fragment="single">VSHVQFKIDVDRKVAKQIEIDVDRIPSQHLVYNNISLKFIYVNILKIVAKRRPAIGYVQGMADLLIPLIEVYKNEFFVESTVYATFSKLLDTFQDYFIDGQQGITKAIKKLRRVLQMVDPILYAHITNLGLELHMFAFRWFNCLFVREFKIEYYLLFLDSMLATSNYELFVIYFAVSLVVNLRKEILSKDFNEVLLFLQSLNELDWEYDELKILFASVYVNVNVFEEKFYYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZA9</accession>
    <name>L7JZA9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein involved in mRNA turnover and stability</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993817">
        <property type="protein sequence ID" value="ELQ76754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZA9"/>
    <dbReference type="STRING" id="72359.L7JZA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0247"/>
    <dbReference type="HOGENOM" id="CLU_096550_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZA9"/>
    <dbReference type="OMA" id="CEQCFCE"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="265" mass="31058" checksum="D577DF4A663B5D86" modified="2013-03-06" version="1">MFLFKRSHNKHKPTNLSEVKTVSAIDPSERCKICYMYNNPIDSTCDLISPCGCKGSIKYVHKTCLRLWRFKGKNLREIKTCEQCFCEYRVEEDLLPNRFLVQVVTVVAALLLFIFCHFAINIVVESLSFIIEEVFFSRGYEPCYERLSHALNAHDCAAGASRSTLSDLFALGSTKFYLTGRHSLLKLSFMETSVMVLIFYQVLFNYGLVSTINLFFTLWRIVNFEYKIDYFFLFVICIYYFKKLYKALYQQIDHVSYFLMNSNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZJ3</accession>
    <name>L7JZJ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993868">
        <property type="protein sequence ID" value="ELQ76152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0875"/>
    <dbReference type="HOGENOM" id="CLU_2591474_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZJ3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="80" mass="9443" checksum="077ED6698B20F467" modified="2013-03-06" version="1">MIIKIDMKEQFNHLLEQLDDAFREINEKVDYMASHEVFMIIRTEIHVDSAKYGLSGGDLKKFQIDICDVRLKISQQETIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZJ6</accession>
    <name>L7JZJ6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0146"/>
    <dbReference type="HOGENOM" id="CLU_2361223_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZJ6"/>
    <dbReference type="OrthoDB" id="425619at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="96" mass="12056" checksum="B02C4566480D47E7" modified="2013-03-06" version="1">MKRYETINKKHLCTVYGKKYWRFDSGIIKEVPEKENTEKPIIEAYLKTNHRKLEPIYYELKERYYWLGMKRHITEIIKRYETCQWNNRKHTGEIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZK1</accession>
    <name>L7JZK1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0089"/>
    <dbReference type="HOGENOM" id="CLU_628795_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZK1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979170" evidence="2">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="445" mass="50816" checksum="AFD0C5F8AD7E0698" modified="2013-03-06" version="1">MNLLRSFLNVVLFMMSSRCGEEGKVTCLGSKPSHIFLSTENAGRALREAVTVSLRDGSKRLISLRYADSIMLMVSKLTKGFTALRDRMPTSDDQFKMFNSLEGKLSQGLCNKRNLNFREFVDIFSLTMLFPEPECFARFREQVDLSKLVKRIDPSRCEIDMQALAWYIEDMHSVARVVNSVCRYAFGVVSMCMRPEYNDLSAILPSLGAWSFESGDIETEKISLSESGDEQPASFNEWLERLSKLRKVIVDYLTIHDRIRLFIKLCKQAKEIEKIIQNNESDYNSHLKSECNRANSFADLSTNNLYCRERLFIHSMYLRDIYGSSPPRFPEKSEISGQGEPPDVLTPMLWLKKYGVLPAELQKSRKQFWEWREKKVAATNIVVEMGGLIDAINAKESAEFKAEACRVTEECVRSFGSGGHGAGSFFKYLFLGGIISGLLWRMYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZV6</accession>
    <name>L7JZV6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZV6"/>
    <dbReference type="STRING" id="72359.L7JZV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0721"/>
    <dbReference type="HOGENOM" id="CLU_121575_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZV6"/>
    <dbReference type="OMA" id="MIINQKM"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="150" mass="16892" checksum="42FA2523CAADB78A" modified="2013-03-06" version="1">MNDPLDLLTNLEKAYEPSSPLYKFTHTFHNLADPSGTTYPIDLKGYDDLIMRNKHQKAVIDKLNSALLAMSQRIDGVIAKSMIINQKMGVLVKMIRSMRGYGIDGKLVFGRMEGELVCGDDGIRCLRMMRRVLVNLSESVKKEIGESRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZW9</accession>
    <name>L7JZW9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0301"/>
    <dbReference type="HOGENOM" id="CLU_3302231_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZW9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="4380" checksum="C38E08DDDF916F9D" modified="2013-03-06" version="1" fragment="single">VSYRRMPSEKVVEVVLLQQLLKNVQSLGISVVALGDVAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZX9</accession>
    <name>L7JZX9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">26S proteasome regulatory complex, subunit RPN5/PSMD12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZX9"/>
    <dbReference type="FunCoup" id="L7JZX9">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0311"/>
    <dbReference type="HOGENOM" id="CLU_055005_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZX9"/>
    <dbReference type="OMA" id="CKIDRIK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="308"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="415" mass="49006" checksum="9CAABC78022C4D80" modified="2013-03-06" version="1">MDELLEQERINRLENNHEQQLQTFTSMLSLCESENDLLILLKLLSKKKNQIKISYQWLIDKVFETHKDGLNSAEFPEENVKFMVEILVNVIEGKLYLEKQRRDYANYIKEIYVKFDMFDKALEIAYNVPIETFSSLSLHEIAIYQLDVLKLCILTRDTIRAEIMVKKVKKKHLEAANDKVSVFMLALLKTDYFGMVGELLEATKILMEILDMPDSYDHKYEVPQFTHFFELRECADHLNRKVKEVFCVYASFFAILSTKRKEKAEYLEKLHKNKYNVEEIRKQIDYFRSIELIDKENVMLVLRRINSSYEKEILEAINDHNLRIISRFCASITFADLSALLMSPLNKCVEKICDEVNNHDLQCKIDQNNGVVFFENTEESYPGMINQVLLNVDKAVMNIRKETLKRQVAMMRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZY6</accession>
    <name>L7JZY6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZY6"/>
    <dbReference type="STRING" id="72359.L7JZY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0321"/>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="InParanoid" id="L7JZY6"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="150" mass="17542" checksum="83EF32CEE99493A8" modified="2013-03-06" version="1">MKNEQITAAIAEITSTQTKIRKKDLLRIASIKENPITKHLLRKFTVNETFEFEKLLDALREFALDDRLSPKIKLLFDLYDCDNDGVISRCDLFNVIKMFSDESLCDSNIQNVVDRCFLDLECEEITFERFKKFIESSNPNLKVFMRCSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7K043</accession>
    <name>L7K043_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K043"/>
    <dbReference type="STRING" id="72359.L7K043"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0614"/>
    <dbReference type="HOGENOM" id="CLU_1897779_0_0_1"/>
    <dbReference type="InParanoid" id="L7K043"/>
    <dbReference type="OMA" id="CGHAMER"/>
    <dbReference type="OrthoDB" id="2190619at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="4">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="135" mass="16105" checksum="929CCA54EFF2FE07" modified="2013-03-06" version="1">MNELLEERERIINKILKYMTENNYMDEDLFLSIKIQTLVKNRPWANEFNLVQLKKEVKESKEYKDLFDIDTILVQNIKISDICCLTQMKIRERWEGVCGHAMERSAVLNYMKKNKSARCPVVGCNMLLKEKRNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7K048</accession>
    <name>L7K048_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Heat shock protein DnaJ, Zinc finger, C2H2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K048"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0022"/>
    <dbReference type="HOGENOM" id="CLU_984142_0_0_1"/>
    <dbReference type="InParanoid" id="L7K048"/>
    <dbReference type="OMA" id="MNGNKHR"/>
    <dbReference type="OrthoDB" id="10359782at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="283" mass="34505" checksum="5C4997F72BB2180F" modified="2013-03-06" version="1">MIKAMLTKFWHQFSFWMIIIYQKLVLLLFRREETPYTILQITDTDKYSTIRRAYRKQLFRYKSTIDKDYSDMTRKILEAYEVIKRKESIYIGDSYFDENFYKRTGECFSNLEMKRIIVDENNIRDVYSRFRMKYRELVKFLKQKEMTLLMPKAHYVKTEYKPVKKTKVKKEKTYKCTVCKKDYQQKTKYIEHMNGNKHRNKCRELGVELNIPDEICPQVKESRERGKSPKKECEEEHARIEKRKVNTMTGTGTFVEPHHFLFCSLCDKKFPNRKELTLHLQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7K085</accession>
    <name>L7K085_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative E3 ubiquitin ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K085"/>
    <dbReference type="SMR" id="L7K085"/>
    <dbReference type="STRING" id="72359.L7K085"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0220"/>
    <dbReference type="HOGENOM" id="CLU_1137987_0_0_1"/>
    <dbReference type="InParanoid" id="L7K085"/>
    <dbReference type="OMA" id="CIDEWFN"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="241" mass="28438" checksum="28CEA8EEE0380390" modified="2013-03-06" version="1">MDSPLQRTQTQRITRFMERLSALQCIKWFVVVVLIFKSLQVIYNTIILVVTMNQHTKAPFKLFISVYNVLVLVQIILFFLRHREYFRVTRLPDIQDNNELSLFSNFVDAFSLFWCLTGFHWTQECKTCKITAPWLYYTTYAWSFLGIFVVISPLIAIVLLIFIIAYFKPNLPVIEYKNAGEINKENANCSICLAEYNMNDKIKILPCNHHFHLNCIDEWFNIDDICPLCKKPINILYDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0A2</accession>
    <name>L7K0A2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0A2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0185"/>
    <dbReference type="HOGENOM" id="CLU_1230671_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0A2"/>
    <dbReference type="OMA" id="DTIIMDH"/>
    <dbReference type="OrthoDB" id="10310446at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="225" mass="26415" checksum="9EC23EE1B38DCBF4" modified="2013-03-06" version="1">MSGSKFKENKSDENTNNENEETAIQDRAHEESVQDIAVPDTMPYKSLMDRNRRLLIDTIIMDHMLFSCATSSAREYAKLTRAFLPRNLRFFEQLKEIKEYILHVKDPLRCLKYIMHNFNVSDSDAQKLTDLHIKVLFLQQLKEQGNQAALCLVKQLRMKYEFVLDVNVYSLIGYTAIKNDFYSHMVSDERMAEFVDEINSVLWCSKFGRKCSLLMWLVDGYDKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0A7</accession>
    <name>L7K0A7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
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    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:response to oxidative stress"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MUSTARD, ISOFORM V"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="190" mass="21717" checksum="3C43D8FB54D375C0" modified="2013-03-06" version="1">MDEHKLTEINMSLLKLLYKGRAYESTILCRKIIFELLENVECKFKVAESWHLVYSSVEHGFSLRTMVDNLSKSRPPFILICRENEGNTFGVFINDKICFKSTLSGKINTFLFKMENGQVKVFKYSGNLPYFCLCSPSFIGFGCSEGKFGLLFNSTLLTGSSSRVTTFNNEVLSRKEKFAVKQIEVWTIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Noel C.J."/>
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
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            </authorList>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
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    </evidence>
    <sequence length="56" mass="6532" checksum="16F9A40F6EFFF364" modified="2013-03-06" version="1">MKQKRKTLTDVTNSTVKLKYPKEIEKGYITDEREIIGMVVSDEECGLFMFDEISDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0D1</accession>
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        <submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="182" mass="21650" checksum="5CAEAF9EAFE3561E" modified="2013-03-06" version="1" fragment="single">VNANMFLCILLIGTNSRLHTPKNTNFAAMINIGNNGHIEDWRSLSDIKQDYIHENSPYNEEPHSKMVREGNLYEDYNPDHTKRNTVIRNEVFDLMLKKNDFRYVDHEIRNMIKRDREEYQNLLAEIGLRPKKDNFGDMNADLNDKKTDPQQKKNIAFNLEVQQHKKFLLNRFENEVDEDRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0G5</accession>
    <name>L7K0G5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0413</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2470663_0_0_1"/>
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            <dbReference type="EMBL" id="ELQ76692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="88" mass="9858" checksum="227925348B7117C5" modified="2013-03-06" version="1">MFADVLNGYWGYNLAKRWPAIVEKQRVLRGIDLSDHCPVVANLAVKSITAVFDKLVHGRSKLLLTGKVCPRMLRNGILTCQLPAVKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR19</accession>
    <name>L7JR19_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3201</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.2.1.141" evidence="1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR19"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0033942">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="126" mass="14534" checksum="FAA9DB6D73F96D52" modified="2013-03-06" version="1">MISIHQPDDRSYLVLNDVILMSHGRIITSGTMLECKNFLIQNGYKQQENATFSSFAMEVLSDISQRYNENSDEKDLSILANVYRKQFNCEGKYGNFRVRNDFCIELAPSLNDISVLMLRRMKLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR22</accession>
    <name>L7JR22_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GATA-4/5/6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_3163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994097">
        <property type="protein sequence ID" value="ELQ73923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR22"/>
    <dbReference type="STRING" id="72359.L7JR22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3163"/>
    <dbReference type="HOGENOM" id="CLU_761151_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR22"/>
    <dbReference type="OMA" id="ANADRCV"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ73923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="364" mass="42778" checksum="68CF8EE8DD96115F" modified="2013-03-06" version="1">MNDTQSYIINGTFHDKDRYNVHKCMRIALANADRCVRMRESNVVWRMWSMMVSGCGNGESVFRGVCRVGSVFGFVDCECEHLFMGRELRNREVPYGSSMGRDGGVMGRARVERAAETMSRDDAMRDDLDDSNIVMGTDSEIMRRKEWLGLEGDASRNEEINMTRCAESRYMRDSRYEMGEDVYQGMKVAMNDREMYHEQYQDRGTAYKPVSYQYPRYYDTKSGTAPTDLPYTHPYSYDEYTAPYDTYKQYAYNQTRYANENYANYPDEYVYKDECANTEECNGYYYEKGSDYSYESKKEYKNQECAHCGTRVTSLWRKLHGETVCNACGLYYKIHGIRRPETLKGNKVRRRRRIPKKKGHYESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR47</accession>
    <name>L7JR47_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3192"/>
    <dbReference type="HOGENOM" id="CLU_2741839_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR47"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="7740" checksum="4051FD8ABFDCAE1A" modified="2013-03-06" version="1">MVERLSHTDRSVISRFMQVNLINSFLPSWEGCGCNTPFCCYEGAREGVARGGALISSTNQRPVAMTSSSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR72</accession>
    <name>L7JR72_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation Diffusion Facilitator (CDF) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_3135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR72"/>
    <dbReference type="FunCoup" id="L7JR72">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JR72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3135"/>
    <dbReference type="HOGENOM" id="CLU_013430_0_1_1"/>
    <dbReference type="InParanoid" id="L7JR72"/>
    <dbReference type="OMA" id="RTWGWAR"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="229"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ73939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="312" mass="35393" checksum="92B51F21D8EB2018" modified="2013-03-06" version="1">MKAGAGLTNTDSENPSTDTDISKIFRVMTIITVFMLLELWGHWHSNSLSLLADSVHLLVDILGFLVSLIALSWTKKKTNNKMTFGYHRYEVIGALISILFIWVATAYLILESIKRFLYPKKINEKSFVLVATVGFIVNLFCLHSLRHGHSDKHVSTNLNMKATYVHIIGDLIQSCGVLLASALTFFFPKIVFFDIACTFIFAFIVLVSTLLVVSEALSILVESAPKKIPMKNVRNDLLEFDKVLEVLDLKVWSVGVNKHACMTVLLCENILIFEYEMILTKIKDILNEKYRFSYLAVQIETKNMRAKYDAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRG3</accession>
    <name>L7JRG3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosylphosphatidylinositol anchor synthesis protein</fullName>
            <ecNumber evidence="3">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="72359.L7JRG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3245"/>
    <dbReference type="HOGENOM" id="CLU_301517_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRG3"/>
    <dbReference type="OMA" id="NEKCAGS"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="788"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1207" mass="135928" checksum="10ACEC8CBBB7BFBA" modified="2013-03-06" version="1">MLPQILNFVCAYLAAYGLFRSLPSMDDEIKNDVKCCDGMYEEDGNGVRFKESSDVKYCDEVVSDMKVGDVKCCDTTSKDVPKDIIHKGTSKGIPKDIIPKNTKKYKKCKFIILDGLRYDATVPTRKCGLYYNNMPVFTTMFHRAILLGIDDRNVVESMRCCFLLSDAFMVMVEYEMMRIVDKRCEQCAAARISRGSRDGSRKGRGVDDCSNGDSKGRDNNYGSNDDGSNDDGSNDDGSNDDGSNDDGSNDDGSNDDGSNDDGNDDDDDSNDTNHIHANHIHANHTTIPTHTTTPNTIPTTNHTINANLFLSMHNPSRITSLYTITTTLYIHSHPTTHHLSISGIPTSTSTRIESIVTGIPTNYRHGLTTFQHIPVPPDNMVSKFRTAVYGDKLWNDLFPSLERTCCLESYEQGLNFEQEIGVMRAIEQCDMENVELLVGHLVYLDHYGHKYGTIHCAQVRDVLRVYNDFVQRLICGLDEDTLLVVSSDHGVENTGGHGGARTMQLASFVFFCGRGIDGRKDELCEYVRRISYGGLFDMNEAWLSIKRVEKGRVDEGKVDEGKVEKGRVDEKGRVDEGRVEKGKVDEGIITNEEITTKGTIMGTTTKGTIKRITTKGITRKINTCTTKTAKKAKKTKTNKQRIKENVNASHQSSKKSGARISYVHQNDIMPTICALLGKSVPFHSTGTFMYELVDRAHFYDAALQKSLKLHRLKTSKNTARAVQLLKNYIRTLSFHQVFALNHALSTILNEKCAGSNLPYVYLGMLVGMLSIIMQFMRMKWKQYDIMRVVVTVVVCVAPSFSVDVFVHEDVLWAVLFVVLDSSWHGVMYALAFVKVGKFPVEGKRAGVFAMMDKRNAIFYLGVLYFVRYYLLNGTCSGMESRSGDGDAGEDTSKDGPNSSRDGLNSSGDDLNSYDLNSSKSNGNSAGQNNSANCFGTHDNTCINTHKNKFTHKNALIKNEQPHNNKLTGTRLITCHPKNNARVFLHAMLSCTCNAMLRIFRLQSRISKSLASFLISLTTYEYIHVLILRYLYQDTPLYRTLTVSMLALNHRLLKYFIYPIKETLFIFYPIHAHNRHNTRSTPVLKRIAYFNACIFASNRTMDLCTIDYMTCFVVSDRVNINSLFSVLLYFFTPRIVNHVPCDELYVFIGSVAFVGSFVGTWLFGGRFGNEYFYGRFFNVGMYFLMDNFVVMVDCIRRMVCRRMTCRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRI2</accession>
    <name>L7JRI2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Concanavalin A-like lectin/glucanase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994082">
        <property type="protein sequence ID" value="ELQ74039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3041"/>
    <dbReference type="HOGENOM" id="CLU_056396_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRI2"/>
    <dbReference type="OMA" id="MISAVEH"/>
    <dbReference type="OrthoDB" id="2187573at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="395" mass="45443" checksum="EE4AE8450D5D7EEE" modified="2013-03-06" version="1">MLLAVFIAAIRAGFNETKIENIKYVNDEDKRLLSFDHAIAKNEGIQMRVSAERGSLVDFKNINTKDEWSFEFTFKNLHLNYPEFAGIYLWYTDQKIHSGDFNGVNNKFSGLMTGIEFLGRGLEIVLGSNDGKETPKHPDDIIILRDTVNPERFRDVNDFRIKVISTKKNFKVEIYDGERLLYDNLRFIEAPILGPREGNKYFSISTQYHKVPADKIFFIRDIQLYERIETEEYDPYLIRAEAPRDLPRYGTDIDHPSKEVQHMISAVEHMMAYLRSILGHPGGSTVLESAMDAKNAVISQQKQIREILGNTDHLLESLKQNGTRIIGSKIGDLELEVKSLQRSLYETQHLINEWGLKMSRMNNNIILVFVIVALISIAVLMLVRRKTESIVKKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRV9</accession>
    <name>L7JRV9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear protein Ataxin-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2901"/>
    <dbReference type="HOGENOM" id="CLU_1397222_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRV9"/>
    <dbReference type="OMA" id="CNDMILT"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="195" mass="22366" checksum="32DE1CB750F949BB" modified="2013-03-06" version="1">MSSAHQISTLKCKKCNDMILTGSVSSHYCTKSDNETKKLHKIKKAFSVDRHCAVPENGVPCRNSLTCRVHSLDQRNEVKGRIYPVEDLIRILKREKNKKRCIQVGEPKPLDFELKNKAFDVIKGLKPVVEYKFDDQKFLRESKEIRSIFSTLKKDNNHGTSMSSTPVNEKNSKKVGLATRKYRQRTPKQSSSVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRW1</accession>
    <name>L7JRW1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994082">
        <property type="protein sequence ID" value="ELQ74040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3042"/>
    <dbReference type="HOGENOM" id="CLU_1939596_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRW1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="130" mass="14275" checksum="A5719914DE2A3794" modified="2013-03-06" version="1">MLQLQSYAIVRRIQRNAEKYCVEERRKNAVSGEKLSKEVIYPGRNENQAKNTAVIVQNSNKGQGGDHISTPNDTSGNSFNVDLKESKETDAVNGKSRSVSNVIDVKNTSSNKAGGNMELKTDENNKTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRX7</accession>
    <name>L7JRX7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">20S proteasome, regulatory subunit alpha type PSMA6/SCL1</fullName>
            <ecNumber evidence="2">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="2"/>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRX7"/>
    <dbReference type="FunCoup" id="L7JRX7">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2864"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_0_1"/>
    <dbReference type="InParanoid" id="L7JRX7"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="239" mass="26855" checksum="C19E20B804CCDBC7" modified="2013-03-06" version="1">MNPSMTGKHEYYAEFCPEGTLKMVEYALEAASTGIPLIVLRTKDAIYCAAKKQTFESLEIPKNFNIVQVSEKVHLAISGFPADIDQIVNSVKDMAAKKTYELGFDVTADILARNLADERQELIQRSGERPMAFTAIFFGFDENTPLLYHTDTSAVFYSYYALGVGENSMKMNKYLEKGYHMDMDHAKALFTVVKGLSESIGNEFSPGNISVCYTKDNNELKYLNVKEIDTILQKISESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRZ5</accession>
    <name>L7JRZ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRZ5"/>
    <dbReference type="FunCoup" id="L7JRZ5">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2845"/>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="InParanoid" id="L7JRZ5"/>
    <dbReference type="OMA" id="SYKGVRH"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="17733" checksum="B4DD81130F067BFE" modified="2013-03-06" version="1">MELNYKDSPQTIQHMIRMCNTNIDGRKQILKALTTIKGIGMRFAQTLLTRTQIRNCRAGELTAEEQQRLVDAIQDPKSVGIPIWMYNYRKEYTTGEDKHLVGNQIDAAFRFSLERGKKIKAVRECRLARGMKVRGQRTKSNGRHGRIVGVSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS13</accession>
    <name>L7JS13_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2877"/>
    <dbReference type="HOGENOM" id="CLU_3353555_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS13"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="37" mass="4510" checksum="CD4A2A0490A6CD23" modified="2013-03-06" version="1" fragment="single">VENCQGKEIRMNVLFTDCRMEDRCDDRGKLEYLRIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSA8</accession>
    <name>L7JSA8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2752"/>
    <dbReference type="HOGENOM" id="CLU_2783034_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSA8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="69" mass="7320" checksum="7A359AEE9A669F82" modified="2013-03-06" version="1" fragment="single">VLRISGCKSVSVVLSGGNLDVLCWSLNSSSGSDGLLIGEDLLFGVEGNDDLDVDILRGRRKCNNKDLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSI7</accession>
    <name>L7JSI7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2832"/>
    <dbReference type="HOGENOM" id="CLU_3302234_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSI7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="4489" checksum="0C65543AC8434D26" modified="2013-03-06" version="1" fragment="single">VKSGDESVLRAKPEKKLTTEEQMRILNGPEAEETIVTITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSS4</accession>
    <name>L7JSS4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2713"/>
    <dbReference type="HOGENOM" id="CLU_543137_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSS4"/>
    <dbReference type="OMA" id="RINTNHI"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="502" mass="59443" checksum="8876CEC1FC6B1621" modified="2013-03-06" version="1">MQPEYTENSLVTNPETRTTNDSGCREAAYTSTQANEVKNTHNRTIKLIRAYNKTHKHMFKARTSRLVGFKRLCDIINFTWCDCDQNRLEKFTTMLSNMNDIEIVEHFTTFKKLCIDFSLSKRKHLPVKALNKSEQRPMSASAKKMIEEYEKCPRHDNINGYIAQLNKYSDTKLSFNTKDKRCVAFKEFLMLIENVINVKCYLNPENADEVTAMEIRKFFFIIKKFCYNYIGLYEQKYHLVENLMNLFNNSLCIFLETRIGEKNIMLPEFLYLKDSFIVYCKSKSKILYSEKTFQIYIISRIEAAISKMIVLNNEIATSQDIVCENNFKLILYRSFVREVLLTNLLFSFQCLNRHISKYIFLSQLEYIYVRINVSTCCLGDNGKFRNFYDVLFWTLSDFYFKISFTKQNTTCAWDSNIDFSRINTNHIIIKLIILQPDVFKRALKKNIRRLFTRQGSRFAQLSRLKKTIWVQINSLNRKDPCLMLLKAHAIYKFLRCYLLANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSX6</accession>
    <name>L7JSX6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994070">
        <property type="protein sequence ID" value="ELQ74141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2947"/>
    <dbReference type="HOGENOM" id="CLU_1972020_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSX6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="127" mass="14731" checksum="BA4043D61D8A7AAC" modified="2013-03-06" version="1">MLMKNTENLDKSNYDAVPSAKITSKYKQRRQGNLAKKYFCRNPDLKLVQPKHSEGFLIMPSRHNPIMNISSLTYIDILSISTVAEALKKQSINYKNMDKTHNHFLTRKNTSSYDQYTLMLHDATFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT05</accession>
    <name>L7JT05_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glycine hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT05"/>
    <dbReference type="FunCoup" id="L7JT05">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2625"/>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="InParanoid" id="L7JT05"/>
    <dbReference type="OMA" id="ANASVMH"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="8">
        <location>
            <begin position="10"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="459" mass="51747" checksum="779493D7B6E3038A" modified="2013-03-06" version="1">MSELVYKNMKDTDIELYNLIMDEKQRQEESIELIASESYVSVPVLQASISLLHNKYSEGMVGERYYGGTDVIDKIESLCKDRALRVFGLDENVWGVNVQPYSGAIANFEIYNALIGPGGRLMGLDLFSGGHLSHGFKIENRKISVTSKYFESYPYKLKNDGSIDYEQMQRDFVHNKVNILIGGASAYPRDFDYKRMRKIADLNNAYLMADIAHISGLVACGKMNNPFEYCDVVMTTVQKMLKGPKAAMIFYRKEKNGVNIQNLTNRSVFPGCQGGPHNQTIAGIAAALKIAKSEEYRNFIDQVLLNMQAMTKVFLESGVKLLTNGTINHLAMLDMRNICMDGRVFSLDGSLFEWVCNFVNISLNKNSLPDDTSCLHPNGIRVGTVSVTTRGFKEDGCTRIAEMLVEIMKKLGSYESLSVEEMKERVKKDKWFAEMRDRVRETVKGYPIPGADLFEKSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT09</accession>
    <name>L7JT09_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3204"/>
    <dbReference type="HOGENOM" id="CLU_023477_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT09"/>
    <dbReference type="OMA" id="DSRIMWI"/>
    <dbReference type="OrthoDB" id="2186662at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="719" mass="82028" checksum="087165BA99DB2F40" modified="2013-03-06" version="1">MNTLILKNHPIDHSAVTAICTNNRQIFIFQNNILTVYSSQTLTKTFIADVKLNVTACCTHNNVLYIGTHNGLYMMVNGVLTKIRECFVVRLCMVDKRLYVVEKKDGEYVLVIDDQDVCRSGKDVFVGWAGNRLVVVGQMVRWGLEEWEWTGDDITSFHVVSRIGGVEDGRSAKWDGGDGRSGEWNEGDDRESKSREGKNKITEXXXXXXXXXXXXSNESIKDANDHSNGNLNNDNIVKHCRKYYGVVTTVTGDLVLFELKNGLILQKLKLRNSSVYAVKMKEDFVITGDDSRIMWIKRDDKHFYYKYGQLGIHYSKTHIIIDNGRIISAGEDSLLNVLYTERNMFYKYFNDNTGILRTNCGILCVMEDKALCFYTISGEICGGRRDDGRGSNTKNDEYIDGNTGCRDGVDCSSNRMNGENNVYRSKTKQRLEYLLRYNTNQRITSYDLNDRFVAYTTADKTCLVHYVFGDRLMIDRAKEFVSCYFLRIIDGKLIMVRDCVVIFDLNEFVEKEVPVEIDVFDVMNYDWDEFVRSDGIDVNGRVGQIGCARQEDGDGKTCNEDVNDNCSSVCSVSSKSADRQVVDTSASVGVVSARPENNEEVHKTEKQKNKMVIPYSHRAGSFFIKNTNKGAFLYSDNTFITKFKKKRVHKIILNKDNLIIALRDALVMMKNNKYCNSVVIGNYVNDVVFFSGYLVVHSDEINFEEYCVESIKEDVYKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT45</accession>
    <name>L7JT45_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994097">
        <property type="protein sequence ID" value="ELQ73927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3167"/>
    <dbReference type="HOGENOM" id="CLU_1012610_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT45"/>
    <dbReference type="OrthoDB" id="2195024at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="275" mass="31122" checksum="614B75D1F3E38640" modified="2013-03-06" version="1">MNRNKERKEERRVKRTNGSKGGAIGNGWEESNGIGAGECIGREDDTVRERNADVEQRSSSIDRDEEEEGMDSDEEGMDSNDDGSDDDRSDEEGVGSISNDSSNEGMDSISNDTNNEGMDSRSSTNPNHTNNVNPTTNEVYQTVHATHNALTQAVYTKNVPFLINFTYCDAQSKTDQIAGLQKQCKVDLLLLIYNALKKGIAVELLDLAVLLLRNSKELLYNREYRRIVEDVVEYLKGYSMEYNKVVYLKGKLSYLKRDRKERKRALVERNEDEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT90</accession>
    <name>L7JT90_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_3117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT90"/>
    <dbReference type="FunCoup" id="L7JT90">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3117"/>
    <dbReference type="HOGENOM" id="CLU_040684_0_2_1"/>
    <dbReference type="InParanoid" id="L7JT90"/>
    <dbReference type="OMA" id="GVWAMID"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ73977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="288" mass="33068" checksum="771AE0903C1DDC6A" modified="2013-03-06" version="1">MTANSNTLRMSAYGRRTTGNKYSAQYQVYVTLEDKIISPFHDIPVYADQDHINVVNEIPRFENAKFEINKEKKMNPIMQDVKNGKPRYVANIFPCRGYPWNYGAIPQTWEDPSVKNTNTNCFGDDDPLDVIEVGNVTKEVGEVYVAKIIGCIGLIDSGECDWKIIVIDKRDENAKHVNDVNDLKSTFPGLQNVTYNWFMNYKLADNKPKNSFLDYGELKSKEFAKNIIKECHENWKRLMKIELETSISRVNALQKEHRSVEEIVISDSEGSVEAVPDSLNGYFYVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT91</accession>
    <name>L7JT91_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2828"/>
    <dbReference type="HOGENOM" id="CLU_3426937_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT91"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="21" mass="2383" checksum="79F42FF8E4486C12" modified="2013-03-06" version="1">MEDDRHVLSTVRMLVGVPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTA6</accession>
    <name>L7JTA6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Subtilisin-related protease/Vacuolar protease B</fullName>
            <ecNumber evidence="11">3.4.21.48</ecNumber>
            <ecNumber evidence="11">3.4.21.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.48" evidence="11"/>
    <dbReference type="EC" id="3.4.21.64" evidence="11"/>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTA6"/>
    <dbReference type="FunCoup" id="L7JTA6">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2370"/>
    <dbReference type="HOGENOM" id="CLU_438175_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTA6"/>
    <dbReference type="OMA" id="IMGIDYV"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="235"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="449"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5 6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5 6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5 6">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="624" mass="68797" checksum="DFFE6C4F5832DDB4" modified="2013-03-06" version="1">MFILLIRYLYATRYIVMLKDNPKRYNYNILSNSVFSALGIGDSVINTLSNGFIGDLEEESAQRLRNNENVAYVEKDKEVSIKDFTVEGGFVLSAGNIGYESKSDELDDKNANRGDKGNRNSEEDESGWDSNTRSKLRYVRGKGANTNRSPVTTNRRLGQTRSAPKDKNRKNSDIQKSSLLRRTGENNKDTSRTRIQSYAHAALEHQDDAPWGISRISSGTKVNSLHTFRYPHSAGKGAQVYVIDTGVETSHPELQGRAFFGANFTTSGSNTDQNGHGTHVAGVIAGKTVGIARKAEIIAVKVLDKMGSGMLSSVIMGIDYVIRKHSEKMERYEEDKRKEYYKRVLDGRYDSGHELSDGLLSDWRGSSTLYRQVKGPLRSTSAFDPMWRISNIVGVVRSFLNAVDKDMLARNGPSDQLQLAGISNPLGTIGSDWLFSTAQSSNYTNNPLNIVSSSQKPKSIVNMSVGGLKSKVLDYAVKYATDIGIHFSAAAGNDHEDACEFSPSSSKLAMTAGASTASDTIAFFSNYGQCVDLYAPGVDIKSSWIKGEYRVVSGTSMAAPHVTGAMALYLGEKEYTPAELIDMLKNDSYKVVHEPGKDTNGNYPLVSIRKLIREIYDKRKRANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTB2</accession>
    <name>L7JTB2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U5 snRNP spliceosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2434"/>
    <dbReference type="HOGENOM" id="CLU_347036_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTB2"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA recognition motif spliceosomal PrP8" evidence="4">
        <location>
            <begin position="241"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-processing-splicing factor 8 U5-snRNA-binding" evidence="3">
        <location>
            <begin position="387"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-processing-splicing factor 8 U6-snRNA-binding" evidence="2">
        <location>
            <begin position="531"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="814" mass="94136" checksum="DFF96F00EEDE3D14" modified="2013-03-06" version="1" fragment="single">RTRNFVWRVKTEELWQCPAMRKMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSSQEGTNGTDSSTQKHKTKNEHQRHRLFDDYKPLERKIYEEMLSAMNVENALPLPEIKNRILTQRVFKEVRFNLRDNISSATPTYEISEDERQIDSFVDLWISYFFNRNEDLFVRDLFRLKAFSFFCTFRIKMQPIDLNLLQHVLSIFIDSNIVQYVIARVNSTVVYKDVNFVNRVGVSKGFEFSFLIYEAYYAAVDFLFKEQDVFYVRRDDRVIIARNDAIFDEQYVEEVLTRRGCFTSIFEAVDHVFTAHEFSFHNVHVGKTAELESICPFVHRIRNINAFQSFLNIAEKWNMHLLSLVVTYREFLTDEHVKTILRWENRILNLIKNHINSKMPTRFPNVIFYAPVELGGLGMFSIGNGVPSLVDYVRPWREVLDEHGEFIGRKGRREASAGGTRNNGHYIAESETLIRNARIRGRYRRYNTGDNPFAHFNSILDGKLWSTKRYKYDMTEFFGGPEHIISQSVLASISTAYDPQTLWRTTTYGTMTKAQLSGARLFPNRRFVFYWSPLINTSDVYVGYATVMDKSGIVMHGKLASLKMSYLKVFRDNLWMKICEEYVVELVRMNGCRKVVVDGKKWCGGMGVDAIFENVMVYDEEGMIGKDDGNENCNGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTI2</accession>
    <name>L7JTI2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2719"/>
    <dbReference type="HOGENOM" id="CLU_057187_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTI2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="323" mass="37640" checksum="786B09653032C905" modified="2013-03-06" version="1">MNNSLPDITNIIIKWILCFCNERESADTDIILCDNLEDYNIVNIFNPFSEHILKDEAIANLEIRDYDIQNDSLRIFQQNVQPHTNYNISNYNMEVVDEHELAKRRNTKVSNEVDTIGYRCRYRTIQIPLTKFLFMKVVKLKMNSDEKFSDDELYKVIDCLLNLLNDELPFLRIFAQQLIADTKLCDRLCVIGKEQIKKEEGTLPKNVSYHMKQESAIYTIQNSFSIYSMDGFGAAAVFSNDSTVRPHLRANLRCLDCFSKPSYLRMDGRFVIHNHEILAKMYESAAPTFSLNVDVDFSDVFYEMARTFADESYSNERIVEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTJ8</accession>
    <name>L7JTJ8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">THOM_2327</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTJ8"/>
    <dbReference type="FunCoup" id="L7JTJ8">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2327"/>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="InParanoid" id="L7JTJ8"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140018">
        <property type="term" value="P:regulation of cytoplasmic translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="72"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="573"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ELQ74724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="628" mass="71902" checksum="272592E9988733F5" modified="2013-03-06" version="1">MSMSGLHTAITQVVSLLIKDHQTNKPININRTISVVAKQYNLKRIPRLTEIISAIPAKYQNLIHLIRAKPVRTASGVAIIAVMCKPHRCPHIALTGNICIYCPGGPDSEFEYSTQSYTGYEPTSMRAIRNRYDPYMQSKTRLKQIESLGHIPDKVEFIIMGGTFLSLSNEYKRDFVKKLHDSLSGHCSSTLEEAIKFGEHGKIKCIGITIETRPDFCFRPHISEMLSYGCTRVEIGVQSIYEEVARDTNRGHTVSAVAFAFRMAKDSGYKIVSHMMPNLPNVDKRHDYAQFQEFFSNPKFRSDGLKIYPTLVIKGTGLYELWKNKMYKNYSPDELVDFLARILMLVPPWTRIYRVQRDIPMPLVSSGVEYGNIRELAMAKIKDYDGCCRDVRSREVGIKRIAEGIVPKEIIMVRRDYVANNGWETFISFEDIQNDILIGLLRLRKCGVDTFRKELISTEDALDKPRNHSEMKTLDDHSWKRNILYHKKDIKGNEYFGKNDESIDEDVAQVGTVYDAKQSNTGNNPRETIKNAQPFDFLAHSQLREIRNNNASIIRELHVYGVAVPVDKQKNGSFQHKGYGTMLIAEAEKIAREEHHSKKMAIISGVGTRKYYEKFGYWLEGPYMVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTL0</accession>
    <name>L7JTL0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTL0"/>
    <dbReference type="FunCoup" id="L7JTL0">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2280"/>
    <dbReference type="HOGENOM" id="CLU_1294389_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTL0"/>
    <dbReference type="OMA" id="IPICKRC"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="247" mass="28974" checksum="BAB0038908157C08" modified="2013-03-06" version="1">MIFVTTNMNWALIVAQIFLIQFKITHLVYTLRMFLYVVLDLQRSSWAQLKDPKELCNNILVLINTFIRMSYDNKAIVINNKSQKVYDHDHPVVDQRDEKVITDIFAYNDIDSIANDIGYALTIARNTSNNRIIIISLTRESKNDYLKYLKSAFVAKRYSDRYNISVFSYHRNPTLSEIGYFYDNFALSTFLQILCGRKPQKIFFCSTKCNCHGREILYGLVCPVCLSIYCSLIPICKRCRIRFNFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTQ9</accession>
    <name>L7JTQ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline 3-hydroxylase, demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">1.14.11.-</ecNumber>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.14.11.-" evidence="4"/>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JH994014">
        <property type="protein sequence ID" value="ELQ74863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTQ9"/>
    <dbReference type="FunCoup" id="L7JTQ9">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2202"/>
    <dbReference type="HOGENOM" id="CLU_029501_2_1_1"/>
    <dbReference type="InParanoid" id="L7JTQ9"/>
    <dbReference type="OMA" id="VHEVYQQ"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="210" mass="23980" checksum="D9E510F18A7173C9" modified="2013-03-06" version="1">MTPSNLEQKYVHNFYATNHTAFSSTRHKPWPSVTEFLNRNKTKLILDAGCGNGRHLSTTSIGIDYTREFLYECVHAANKRALALMACDVSCLPFRDESFDAVLSCAVIHHLENAREGVEQLYRVLRAGGSCMIVVWAVKAVHPHGSRKQNGKFVRIRDSEYLVDWQGKGQMRFYHLYEKDELVELVRSVGFRVVACREEDESINLEAVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTV1</accession>
    <name>L7JTV1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyadenylate-binding protein (RRM superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTV1"/>
    <dbReference type="FunCoup" id="L7JTV1">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2159"/>
    <dbReference type="HOGENOM" id="CLU_1215098_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTV1"/>
    <dbReference type="OMA" id="YLIMQRA"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="171"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="245" mass="28300" checksum="537176FCD9D1A6BB" modified="2013-03-06" version="1">MAKLFVSNLPLNYTKTDIKQIFTAFGPLKSIKQYITPKKQESNIQSAFIEYVNNDDAVVAVKSLRNKKFYDRYLIMQRAYERYNKLYVGNLDDKITAEDLHSYFSDYGRIAAVQREKENDYAFVVFEDAKVAEMLVNNHGVKKIGGNSRPVILKRAESKTESRKRQIPYNRSVCVKNMPTTTTEDLNAFFEDCGCVERIQMGSKKAFVVFRNELGALKAMKYKNKKEFNGRRLAVEIFTDAKKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTY8</accession>
    <name>L7JTY8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994037">
        <property type="protein sequence ID" value="ELQ74516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2560"/>
    <dbReference type="HOGENOM" id="CLU_3015878_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTY8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6893" checksum="C3A4CB617977AC63" modified="2013-03-06" version="1">MDINEKEEKRLLLQYFKLRLDTETQVYLKQLRVDELDQIMEALKDHQEMILSNINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU14</accession>
    <name>L7JU14_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU14"/>
    <dbReference type="STRING" id="72359.L7JU14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2160"/>
    <dbReference type="HOGENOM" id="CLU_164171_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU14"/>
    <dbReference type="OMA" id="NEFYYTR"/>
    <dbReference type="OrthoDB" id="2188586at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="133" mass="14301" checksum="72A2C3D4BB35F73D" modified="2013-03-06" version="1">MASEPQANEQTLKKSFSSRINPIIRNVVANGAKGYVFGTLVGLLNSRKSIKCTLSDMHSSGKRFMMLGMIYTGSEALIETVRGKRDPLNVLGASAIAGGLVMSRNGLGKSVLGAVGFSVYTGLNEFYYTRDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU17</accession>
    <name>L7JU17_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994001">
        <property type="protein sequence ID" value="ELQ74978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2089"/>
    <dbReference type="HOGENOM" id="CLU_1518915_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU17"/>
    <dbReference type="OMA" id="FRRHENT"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="177" mass="21071" checksum="A75F59CB350DB7D6" modified="2013-03-06" version="1">MIFPFTFQFSCLVIFKIKNVNFVGNMVLSFIIYMLMLYATDSNRAPNPDALSYTNRRLTVFKYIGVVCDCAEGREMLRIDESFFRRHENTPSSKMAFMCYETLLKSVDTFSMFLLSFLAEDGVVEQELDRIQIQKNIMKIKKQDEIKERIFESIRSRERRRQEQERIRLEQQVDLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU22</accession>
    <name>L7JU22_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU22"/>
    <dbReference type="STRING" id="72359.L7JU22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2844"/>
    <dbReference type="HOGENOM" id="CLU_043216_3_0_1"/>
    <dbReference type="InParanoid" id="L7JU22"/>
    <dbReference type="OMA" id="ATRVYEQ"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF2">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="223" mass="26028" checksum="8DD008492E0312E5" modified="2013-03-06" version="1">MFTPSNIKKLINVTTITFRKNNVAYEVPIYPNTLKPYQNNLIPLSSVVHTHSIYKSVSKGLLHNKEALKAIPGENMDQKIEYILRNGHDKQESMTRDYNTERKTRNVGTYLMRKIRYRGRRISLDEAMEIVKKYDLSKDVKVVGNNIVKDLTAKDADYEREKFKVRVDTRYVNDVTQTFGIEHADCWMKMDGDVLRKVKAWCEQRGIGCEIRDESEDEDEVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU38</accession>
    <name>L7JU38_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase (Reverse transcriptase), Non LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU38"/>
    <dbReference type="STRING" id="72359.L7JU38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2829"/>
    <dbReference type="HOGENOM" id="CLU_894832_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU38"/>
    <dbReference type="OMA" id="KITRICD"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="311" mass="35915" checksum="AA19FF9B0D6255CF" modified="2013-03-06" version="1">MLDFYKLMSNDKRIKSEFSKLLFSIITEIYETARILTQWNEAIIVPVPQKSDLHSIDNHRGISSVNTLCKVVMKMVIDKITRICDANRIHRCEQDGFRKLEKCVAQATCFYEIIKRKILEKHKTIAIFLGLSKAYDRMLHEGLFAKLQSYDFGGKLLNFIKAIHIRPMSSVKMGDKRPNLFDYNTGVKRGYPASPILFTLYINDLFEGFIRKKIGPNTSVPNLLFADDAVLFTEDCDEAKSCIPRIKQGCAKRKIEHNIMTCSVMTFNTETTAIIKYKNMNILQVSSYRYLELPIDGELNMNTIINDRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU45</accession>
    <name>L7JU45_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994018">
        <property type="protein sequence ID" value="ELQ74825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2245"/>
    <dbReference type="HOGENOM" id="CLU_572648_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU45"/>
    <dbReference type="OMA" id="YEPREAI"/>
    <dbReference type="OrthoDB" id="10310821at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="453" mass="53350" checksum="ADFDC12CA061DF07" modified="2013-03-06" version="1">MWSNLYGYVEMSLKYIFVFSNEQKTNEENFLIFENPEDAGMTYLLNQHEATKTKLALPYETQKRIYFEKKEVDYETIYDHVHYHSNIAGIRRIIYRTYHDIIRENADVRFEVVHVPFTILLYQKVMKYSQRDVDPNMNTEEVCTLLTHFALFDEYVKESISYIICMHLIKNPKLLHNIRNYRDKPNENQYTPSVRSLSLLIFGNSNVSILFRKVVKSYVEFSLSDNKGNSAQIRKERENNQFYVYNIYPNHFTLEFLFDKLDIEFEWLQNNMNILDEKFDKSVCGSPYSVFIYRKSSTYEPREAIDKLMQDLKMVIASKFITGNNISELTLEFKGIYTGVDLSCLNKIKASIRADCKYCTLDFIRSIPENIKIEMRIAENMSADALNNIPKNVVKISFTSVNFTENMIFPEHIENIIVSKCDSNPNVILTINKMCRNVEISQTRAKPCVSVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU63</accession>
    <name>L7JU63_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2205"/>
    <dbReference type="HOGENOM" id="CLU_2887428_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU63"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="63" mass="7522" checksum="C5F6D578F6C71489" modified="2013-03-06" version="1">MNKKFEEGYREAFEDITNDLYFARGFVLRNSDLQLNDVLSMDDGQILRMYRKLRNAIKGSLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUB2</accession>
    <name>L7JUB2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">THOM_2051</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUB2"/>
    <dbReference type="FunCoup" id="L7JUB2">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2051"/>
    <dbReference type="HOGENOM" id="CLU_016428_4_2_1"/>
    <dbReference type="InParanoid" id="L7JUB2"/>
    <dbReference type="OMA" id="EHRMVAP"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="22">
        <location>
            <begin position="186"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ELQ75009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="509" mass="59295" checksum="131284A829C265E0" modified="2013-03-06" version="1">MLDVSTPKKKTQKSRTPQRYRTITRSTKKDEWYGLDLVSQGIKFLSKCLFTLKFLKELHLQNNELTFIPKGITELRNLEVLDVSDNKLTFLPKELGRMIKLKILKLDDNFLSFIPMELGTLYQLETFSVDNNPLLEPFATLYQSKGGISVIHFCREHNTSYPVPLDRTWVDYHNKTEGMGELLSIASYNILSPHYATSQLFGYVPSWVLHWENRKEMIFQEIVSYNLDVLGIQEMETYSFIENFKDQLDHRCNYDSLFYPSGRSQSLPESQKMSVDGCATFWKRHKFTLIDQQCVKFSDLVFTDERFCKNEDIMNRNSGKDNIALITVLEKTNGGLLIISNAHIHWNPEYKDVKLFQTIILIEAVQKFKEKYPMAGIILLGDFNSMKNSAVYDLIVNGRIYPFNIDFSLYNYKPFSTDGFLHDLSVKDAYREQELELTNFTAHFKGVLDYIFHNDRLILCSTLSSIDNEYVHRMVGLPSIHFPSDHILIAAKFYFKGCRMKKKDLKSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUD1</accession>
    <name>L7JUD1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2430"/>
    <dbReference type="HOGENOM" id="CLU_3320322_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUD1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4579" checksum="A67064DDCA18441F" modified="2013-03-06" version="1">MGENEEKENTDYIYFCSIVDDVCEFISEEDVLDTDLINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUK8</accession>
    <name>L7JUK8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUK8"/>
    <dbReference type="STRING" id="72359.L7JUK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1943"/>
    <dbReference type="HOGENOM" id="CLU_2656206_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUK8"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="3">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8330" checksum="09C805003D792DEF" modified="2013-03-06" version="1">MANDHKVNSYSPEGRIYQIEYAMKAMNHGVTTVALATTQSVVISSEKKILSKLQVTSSATKHFKIDDRIGLAFSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUN6</accession>
    <name>L7JUN6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2577"/>
    <dbReference type="HOGENOM" id="CLU_545352_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUN6"/>
    <dbReference type="OMA" id="FTTKECI"/>
    <dbReference type="OrthoDB" id="10338078at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="500" mass="59637" checksum="A8A73C59ED8F3CB5" modified="2013-03-06" version="1">MISTKSIKMYCLEEKRIIYKKKIPVKGSNAKNNRLIVATNDSLLLFTVTPTELLEQRTLNYQTALNIFGRIYGFENKPTKIDKKSLLLRNMHMPVFKIKNEHVNSILPKKSTSKLKVSNKFFIFNNNIKVIRRRSITVTYKGGKLSIYKHNKKVKSFFDNVRQIILLKNLIVFTTKECINLYDFKVWKKVSLRNASIFQIRSGILVFTRNKIYLFDQIRNSNKFLLGICERACVVYRNENVHDIIHLLEFTKNYKELLEISSHYRFRSHSFVESYLKLLIHGSELDSTIIIPMNNLFKTYKFTLFYETALLAQQHNRILFAQYLIAREQNIYKKVHFLIKYKDNNFLSKLITEETNHIFLHHLFSSMRLYLSKNDILSAIRNEDSYLKYKNYIKHFESEYLEFLEDCSRYDELFYFKLERNMIDPRIPLKKAFNARIINILSKFYSLKNYISKHYNYDVGTVDQAITFLLSNNDKKNAFSLKYLSVMCKEKFDYLRNTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUN8</accession>
    <name>L7JUN8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993986">
        <property type="protein sequence ID" value="ELQ75139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1924"/>
    <dbReference type="HOGENOM" id="CLU_2020864_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUN8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="123" mass="14107" checksum="EF6D9959CA27AB48" modified="2013-03-06" version="1" fragment="single">VEGLYQAKKISLDSFDPAYLYFESKGDFVFTSAQWDHFQFISFGYISLVPIRPCRNRYYKGDTSTDEVKRDKNYNFDSTGYLGFVVNNVSKSSTIAQQLGYAENSTDTVWYSFDSYGQINIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUT3</accession>
    <name>L7JUT3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1846"/>
    <dbReference type="HOGENOM" id="CLU_809379_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUT3"/>
    <dbReference type="OMA" id="YHIIAFA"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978826" evidence="1">
        <location>
            <begin position="18"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="115"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="343" mass="40485" checksum="1B746D2FDD684490" modified="2013-03-06" version="1">MLTNTSLFHLLYVLVCCDVQYMLDKKNKPKMDKEGRFIPKLFYNDTQFDDYSCYSSMDNFMFKAPACIYQSTSFSRNNYKDLIAFSEQTIYNIENNLPVLYSRHVIEKIRRNPECGLVNFNAHCYINAVVQILFSSQKFVKCMQANAKKCKILHLLNELYMKMKNHMLVSPLSTYLKISEQCNILFNVYERSGYSSDVICTISKNLENHSIRIMSIKANQECFWKYPLLDIVDDGNVQERINKLLERKPNIKFGEIIVFTGFLTDNMLRCHITDCNVITIKNVRYKLLGILERVLNNFNGYHIIAFAKRNNEWFMFNDECVLKINANEVLENKETYYIFYEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUX9</accession>
    <name>L7JUX9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription-coupled repair protein CSB/RAD26 (Contains SNF2 family DNA-dependent ATPase domain)</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUX9"/>
    <dbReference type="STRING" id="72359.L7JUX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2484"/>
    <dbReference type="HOGENOM" id="CLU_000315_17_8_1"/>
    <dbReference type="InParanoid" id="L7JUX9"/>
    <dbReference type="OMA" id="HWIRELT"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="127"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="515" mass="59926" checksum="D7920D3F9CB5D67E" modified="2013-03-06" version="1">MVQMEKTRQELVRSLRLVDEMEADEKNEQNYDLHAKDGPESFVYLLGEMNKTEPDERFTRFVHRIRSVEKLYKDHFGVEDVESHLREEHVLIVQPKDEDEAVGAIYCPAYVYNFLLPFQQTALTWFCSLFMGKHGGILADEMGLGKTIQAIAFLSSLLHSNKIGGVLILCPTTLLEQWFLEIRRIYPFVRTIILHNSFIESIDKTLDQKIIDGRMGENFRKTIVVASYEGFKIFFNKIRGLNLDILILDEGHKIKNFNTQTFKYIKTYNCLTYILTGTPVQNNLRELWSLFNITNKHLLGSYTDFHEQFEDVILKGTRRKADKKEKENSAQRTAYLKSLIAPYILRRTKKGTNLPKKYEKIAFCPMTTDQISMYKEFIESKTVSDIIKGSRNVFYGLDVLRKITNHPSLYKKGVHGESGKMHMLAALLKKWYEGVKDDGLNAEPRENSDRMPMNKVLIFSQSLEMLSIIESFIASNKYAYLRMDGTTSLMERKRRLDMFTKKDYFIFFSPPGWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUZ6</accession>
    <name>L7JUZ6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUZ6"/>
    <dbReference type="STRING" id="72359.L7JUZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1795"/>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="L7JUZ6"/>
    <dbReference type="OMA" id="KIGGYPP"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="105"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="300" mass="33944" checksum="E4BD08C03D1CF82A" modified="2013-03-06" version="1">MDVLESKVLNGQILSAQEIDHLCTKVISILVNEPNILSKSSPITIVGDIHGQFFDLLNIFKKFGSPKCTRYVFLGDYVDRGVHSVETLSLLLIYKVMYPENMTILRGNHESSKISSIYGFSDEVRKKYGDLAAYRAFCEVFEYLVLGCIVDGRLFCVHGGISSSIINLDDFTKMPRFYHAPEKSKIGDLLWSDPSQQLGFTPNVRGTGCAYGNDVVTKFLMVNQLQKIIRSHQLVMEGYKFNFKDESVATVWSAPNYCYRCGNIASVLMVDGEVRKENFRLFVAVDDQAPGYDLRSLFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV31</accession>
    <name>L7JV31_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1880"/>
    <dbReference type="HOGENOM" id="CLU_1332816_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV31"/>
    <dbReference type="OMA" id="EVCLHFC"/>
    <dbReference type="OrthoDB" id="10364184at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="206" mass="23903" checksum="89B2FC0BC98AA1E8" modified="2013-03-06" version="1">MAQKKRQSKRRTFNRRKRKIFKSTLKKDKKVPPSILRTDDSTAALTKIRMLEKQRNAGHGTHAATRPILLNSRDPVSVDGDVYMDNNSPVSDYWKKKTSAKDFDPTKKYDVPNTPYTQILSGRVPNKEKTYGVFGDMIAYLSVKEVCLHFCLPVFESVNEFVEVFEEEYGLKGWREVAAKVFGEMKKDKIYFYRDINGVMNFEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV68</accession>
    <name>L7JV68_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV68"/>
    <dbReference type="FunCoup" id="L7JV68">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1675"/>
    <dbReference type="HOGENOM" id="CLU_011106_4_0_1"/>
    <dbReference type="InParanoid" id="L7JV68"/>
    <dbReference type="OMA" id="RTQGFNH"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000200">
        <property type="term" value="P:regulation of ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="160"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="422" mass="48658" checksum="E491A448140014F1" modified="2013-03-06" version="1">MVKENFYRSQRKTNLLNMYNNRPKYSAYGEILRPAHFQSTRSKVAVIPPNYKLFTSTRTINMNEITEEKERSAYEVLIKKGQVPFSILSERKGKVKLEYKDIHKTKRARVGNLLLNRRANDGESVKNQNNDENEKQKRVKEQNAVPEEDALRPGRSKRIWNELYKVLDTSDVIVHVLDVRYPKMFLCKQVIEYVKQNEHKNMIIVLNKVDLVPTAVTKKNIDILSKHFPTVAMHSKSLFNFYGKNNLMNLLRQYKKIHKKTISVGFVGYPNTGKSSIINVLLNKKSAKTAPLAGETKNWQQVKLDKGIHLFDSPGVIDVKDKPICEDDLEYSAVLMGAVRVEKIKDPEVYVNQLVKIAKEGLEKKYKIAIENEDLFLEQLSQKMGKLNKNGQGDVHLVGKMVLNDWVQGKIPFWVEATDIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVD3</accession>
    <name>L7JVD3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2374"/>
    <dbReference type="HOGENOM" id="CLU_837252_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVD3"/>
    <dbReference type="OMA" id="DMFKECI"/>
    <dbReference type="OrthoDB" id="2195910at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="332" mass="37833" checksum="AB627816D6E4C84A" modified="2013-03-06" version="1">MIFLLLYNFIRTDDTMICNDINTNSFSDNNLMAGMYTPNKEMLSCRSAGQPDKLPSNIPFINTGSTQGSYTPTSYIQVGQPVYSGTAGTTYTPQQSQYTYSPTSSSYQLSSVPAAQVPLSSPLNINALQPINDKKFVSPCDNTDDEDMFKECIKKALKSLRSIINNCKKTLGNVEICCIDDKCLESLKGIPFGKDACEVRKERMCKDECHGQSLYGGSKDSCNKHKDDCDGHKDDCDMHTDRCDDDEDKDKKKRRKSKDKKKGKRKRRRHGRRDGEEEEEDDDDSTASYSDEDEYESRSEKRKDKDKRKKKKTKKTKKTKKKERRLTRALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVE8</accession>
    <name>L7JVE8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA topoisomerase 2</fullName>
            <ecNumber evidence="13">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_1646</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JVE8">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1646"/>
    <dbReference type="HOGENOM" id="CLU_001935_1_1_1"/>
    <dbReference type="InParanoid" id="L7JVE8"/>
    <dbReference type="OMA" id="DVKPHMI"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="452"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="17">
        <location>
            <begin position="725"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ75404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1474" mass="167977" checksum="9EE84ECC84F9D0FD" modified="2013-03-06" version="1" fragment="single">VLELECNCIREFARIARSGLPRIFIKNARAPPSMEKKTIEQLYQKKTPIEHILLRPETYIGSVDHHTQPMYVLENGKIVSKSITYVPGLYKIFDEILVNAADNKIRDPSMSKLCVDIAGDKISVWNNGKGVPIKMHKKENVYVPELIFGQLLTSSNYDDKEKKVTGGRNGYGAKLCNIFSSEFIIETADSKENITYYQRYSDNMSKREEPVITKQRVRESFTKITFTPDLKRFKMENLDEDVISLLKKRVYDMCATIKRVKVFLNGEQIPISSFKQYVSLYLGDDVKVVHEVVNERWEVAVVLSDEQFQQVSFVNSICTIKGGTHVNHVLDQLVEPVIERVQKKDKNLVIKPFFVRNSIFIFVNALIENAAFDSQTKETLTLRVSSFGSRCTLSDDFVKHTVALLSDRVLSQALAKMSKQLKKTDGSKSSKITGIEKLSDANLAGTKNSQKCSLILTEGDSAKTLAISGLSVVGRDYYGVFPLRGKLLNVREANHKQIMENEELNNLKKILALQHHKDYTSTESLRYGHVIIMTDQDHDGSHIKGLIINFFDHFFPSLLRIEGFLKEFITPIVRVTKTKGSRTSRSNSEDDSDEHTNTPASSDPVGTVIDFFTIPEYEDWKNSTPDIKNWTVKYYKGLGTSTSKDAKQYFSNLEKHVKSFTLLTTEDQSLIDLAFNKKKADDRKLWLKNCVPGTFLDHSAHKIPIRDFINKELILFSMADNVRSIPSVVDGFKPGQRKVMYCCFKRNLKSEIKVAQLVGYVAEHSAYHHGEVSLQQTIIKLAHDFVGSNNINLLMPEGQFGTRLQGGKDAASARYIFTNLASITRKIFVESDDALLNYITEDNMKIEPSFYVPIVPMVLVNGADGIGTGWLTKIPNYDLLEIIDNIKLLLDDQEMNTMVPFYRGFKGEIEDLGGKKYRISGIYDVDGDNLTITELPVKIWTQTYKEFLEKKIEKGDVKEFREYHTERSVHFEVNLAVSGEIDKKFSLSSINIFNNFVCFDRHGKIKKYESAEEILREFYSIRLEFYNLRKAHMLNTLEEQLKRLHNKVRFIKEVVNGTLVVSKRKKTDIIAELERKEYYKIEDTYDYLLNMAILSLTLEKIERLNEEYRNTQREYDELLGKSAKELWIYDLEVLRTEYLRLLEDDERVMNEQAVRTGDGGAGRRRRKTRSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXHLLIIDISRTIPTRNEDPKKSAVLVITGSATTPAISTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVF1</accession>
    <name>L7JVF1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dUTPase</fullName>
            <ecNumber evidence="1">3.6.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.23" evidence="1"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2069"/>
    <dbReference type="HOGENOM" id="CLU_2677958_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVF1"/>
    <dbReference type="OrthoDB" id="10261072at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="75" mass="8548" checksum="9FA7EC9DDE6DA83E" modified="2013-03-06" version="1" fragment="single">VDLGFKIDLPEDVLINLYMRSGLALRKGLSVVGKRIYGSNEEVCVEIRNYSEEVYRASKGDRIVQMVFHEVLTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVH1</accession>
    <name>L7JVH1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1522"/>
    <dbReference type="HOGENOM" id="CLU_3020138_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVH1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6625" checksum="E4F80BB26F41DE23" modified="2013-03-06" version="1" fragment="single">VCAKRKKKMPNDLAKNGWKYEMRSCHGVVEIEWKDKQDVFIPSIINQIIKQIPKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVI6</accession>
    <name>L7JVI6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1538"/>
    <dbReference type="HOGENOM" id="CLU_2529070_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVI6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="84" mass="9804" checksum="B779B3C4DF025C0C" modified="2013-03-06" version="1">MYTIFVGVFNRLCWKDISLMSNAYTTESQGDLQTIFVGDSVKKAYIVHCTSLQRKLLKCFSSEHIYFNVPFFPSFLFVINVYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVM7</accession>
    <name>L7JVM7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993968">
        <property type="protein sequence ID" value="ELQ75355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1698"/>
    <dbReference type="HOGENOM" id="CLU_829454_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVM7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="38369" checksum="1CD5E267F1724008" modified="2013-03-06" version="1">MIDEIINEFINIKESRALYNMPVSFLLLFLIIRLTWSVNSNSTRKDGSVDGSIPSEIRMKNDERKVVKWPGYHPFRTQSDSTNSLSENTLPYDLSPEVNNETEPRTNLDGFKKQNNDGYCRFPQLRIERNRKKCINGNINNQTRYNTGDYLGVEDQIQTNRWYSVKSQVNNFKDKKNFGKYPMEHKNVANLPSDKENDNVENEDASSISDCKKDHENVSISSNESCEGRGKEKETLDISNEKGFSVQNAAINDESLHAAIVSHEIQRVLVGPSKAVVPSARSSKYRKSFDDKIQSGRVKKIITEVFYEEYDEDLGLSDKDQNLYSNGRDIVVNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVX0</accession>
    <name>L7JVX0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993938">
        <property type="protein sequence ID" value="ELQ75628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1417"/>
    <dbReference type="HOGENOM" id="CLU_1699801_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVX0"/>
    <dbReference type="OrthoDB" id="7615285at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="53"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="155" mass="18696" checksum="4F347D3E51875836" modified="2013-03-06" version="1" fragment="single">VISDEPDNADYYQPPELWVWKKNENQPKIWQYMEIPGIKAATLDQLSTNKEEIEVFNIMFNNIFWENLVTETNQYAEQIINNENKRRKIDKAWFPIDREELKVYIALCIISAEVKKLAIQMYWSKRAFIATPIFRQMIPYKRFLQISRFLHFANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVX5</accession>
    <name>L7JVX5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA mismatch repair protein-MLH1 family</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVX5"/>
    <dbReference type="STRING" id="72359.L7JVX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1404"/>
    <dbReference type="HOGENOM" id="CLU_004131_2_2_1"/>
    <dbReference type="InParanoid" id="L7JVX5"/>
    <dbReference type="OMA" id="IADCFVC"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="1">
        <location>
            <begin position="64"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="461" mass="52873" checksum="77F1F044A87585E8" modified="2013-03-06" version="1" fragment="single">VGYQAINETKKFYFNVNGKDLIFPGVSQEDTPNECAENSSSILQKDVGLLNEESGTNCANNTDLSRSNNEFSTERINLKMKILDRYFNTGNNLSYNTKDNILVIYSSPVHHQKDLILILSINNRLVKSPTLKSKLYNLYRPFLPNRSFPFIYVEMKVENCDVNVDAMKQRVLFVGEDDLFERVCEMVGKGLVHGSVGVCKVTMAKNELKVYDDLKVKNLENYEFKSNTNTHREAAAVEEIKENTSMLNVQRKEFEETCSRSRHLDPVVINEDKSADKQSSERIMRDYSQDASASSILSDKERKNYQKNATNRFVKDMKYVGKLNDEKIFVQLNTFLMQCDYKKLLRCYFVQQLITQKGRFKTTVVKNSAFTASDGLKKYGIMNVSDGITVPMISNVVMDVSHLQENTFDKYSIADCFVCGVKDYETFFSIIKRGINEDEDVFSCFSVVTGLNELYKAFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW19</accession>
    <name>L7JW19_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1557"/>
    <dbReference type="HOGENOM" id="CLU_547668_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW19"/>
    <dbReference type="OMA" id="NEMPREI"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="498" mass="58486" checksum="8E55E44A19E54BBF" modified="2013-03-06" version="1">MLHNLYDYVEKTLKVILIFETYTYTGCKEFLIYGNLGKSELDNFLRTCSTESISCSSLCEIKKELRSKSYPTIEPQRRIIANKAWRSTFLQPVFALKKAEYKCFYEVIEQNNDISFVTLNVPLSKSLFMKIVNLKDIYAEYYTNCEMYMILKYVFPFKYRIKWMTSVACTHFNKNFALVNKLRQYSEDPEKYEFNHQTTFLSNILFGTDDIALNFRNAVNSYISFSLVGINDQQVSTTRKADTNKIIKVINLHELSIEFLFDNIYLNYSCLEQNDDVLNDKFNKHVHKRLLVVEIYDEETNINNVGANRNLYNNMSIVQKSKFLIGKNVGEIILNINEMPREINTSIFNYMNVVTIVRCRLHPNDFISTFPGHVQVILELCNVRINDGILSSHPNIIELVFIECEFESDILFLNNLKSVKLLRSTTIDGVILTFNRNIQRIMIESSKGQFNLSGIGGFNRIDIKKKNKTFFKYEKKEKYYCWMCWTCISMEQYTLIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW62</accession>
    <name>L7JW62_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1365"/>
    <dbReference type="HOGENOM" id="CLU_341363_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW62"/>
    <dbReference type="OMA" id="AMEYSSY"/>
    <dbReference type="OrthoDB" id="2193079at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="831" mass="95671" checksum="BF37D6587A2DB280" modified="2013-03-06" version="1">MSSSERITELYEGYQGGKKLTSTDIVYLNRILTEKPNMYVRSMLTAFIRQLIIDGEITLTPELLHQIVQGLKFNEYVNVDVAMEYSSYYNDLQDVIFGIFKDNMNLPFVKAEMNRLVENVAFDKMGANLIFVTDASPKNHLLCVLKDLKEDEELITALHTGKNEIQREYLMKVFLGLKKKILESSSRIYMTCVAEINEVLCMSDLDLINVKFELTENHLRYLNALCVNGPCSLQAHSILEKYGVLADAFYAMEQTVETGKMMLPVDLRLLNQVLKILAKVTRVDKCAENKNIELMVGALFSVLPNATKGTLCRILANYDEKDDRKIIISKLTESIGMLYDIYGREDGAYEFVRGFVYFVKRCVCGGERRKRCGAVDDETNEDEERNGGEMVVRSREGVNLGTGGAGAPGWEENFEYDDVVKNAITEDATKVLNTKIVDFVIFVMRTENTEIIRSVLQILLYVDVRFIYDKLMRQQNYLKKALVKDYVINNLLIGIFMDVEMPELRTFDYGLLARMISVPCSEFFQFFRKFDFAVIALFLNEDLLEQIGNNRKEGFSFLLDHSDEMCICRFVERNLSFLVSLENRDVLVLVDRVMDKINVKDVHVVLQNMKMRRFVGEYYSILSKKMVYENDGNIVDLRESVELMNESTRASYCRLLKIKMVLGEDISGYIVPLITYSSACIDDLITFYYVCTGKDVKSVNTLLYKAFSRKDNSLFILNYEEADNFTRYALFNALEDELDERIKNIIIAQISDILGQERIDEQGVELLKMCIVTLLRCKDVDDAVMLFDECRIDEVKDLVRMLVKKNLAERGTCYIKGDDDEEMKYLLSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW65</accession>
    <name>L7JW65_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID, subunit TAF10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="L7JW65">
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    </dbReference>
    <dbReference type="STRING" id="72359.L7JW65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2044"/>
    <dbReference type="HOGENOM" id="CLU_064104_4_2_1"/>
    <dbReference type="InParanoid" id="L7JW65"/>
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    <dbReference type="OrthoDB" id="154356at2759"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAF10"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="124" mass="14103" checksum="FB4FF19DA7DDB194" modified="2013-03-06" version="1">MNGKQEKDEKPKDGTTVVQPKDEGADINLDDFTPLIPDIVLDHLLERSGVDCADKETKKAISLLAQKFITDVATSSFQFHKIHQKAAQKDKRFPKEKKLTLHMNDLEKALEEYGIDVSRPSYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Nakjang S."/>
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="OMA" id="EHEEWSH"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ELQ75286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
            <dbReference type="EMBL" id="ELQ75718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="34" mass="4126" checksum="2958357A5800999C" modified="2013-03-06" version="1">MERLHLDVKYDLIVVRKGYAYLKLNNLPPNYNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW96</accession>
    <name>L7JW96_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
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                <person name="Schweder T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ELQ75674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="6580" checksum="86116FDB23268743" modified="2013-03-06" version="1">MLGCQELNIYEDPLKDEFLGVFLGGGCHASHDLRVKVTVAVATYLSVVMMVRAKTLCGAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWG1</accession>
    <name>L7JWG1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
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                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="7083" checksum="2E118058E7BB0B95" modified="2013-03-06" version="1">MMCVNVLIARKKEKKDKKRKKEKKRKKKKKRKKKKKRKKKKINKSQVEYFLLFFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWK6</accession>
    <name>L7JWK6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <position position="1"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="163" mass="19128" checksum="A1BB7223A6A7A6D1" modified="2013-03-06" version="1" fragment="single">VLNRGDKGNLLNGMDRGDVLNREDSRVIKHGDDNRVIENRKDNKEVLNNELNIININRDDNKTGNTINDTANSKNGRNITANNIKGIFKNNNEKNNKNVNKKNVTRVENQKLSRDNQNFINYRSSIARIPDFYIKRHKYSKRRTRLTERYLNDNMSLLDRILF</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
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                <person name="Becher D."/>
                <person name="Bernhardt J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978931" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="5707" checksum="162CE2719EC3D9FF" modified="2013-03-06" version="1">MDKIEFPLIFSLFIVTVICSNYESAIFNDPELNYTEIVNTNTVGYQVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX32</accession>
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                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
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                <person name="Goldberg A.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="31" mass="3400" checksum="E4EA4C795D60FFA4" modified="2013-03-06" version="1">MSMLMGICLLYQVIGHDSTISVCVIGNAWMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
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                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978849" evidence="2">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="445" mass="51495" checksum="568595908B24CFDA" modified="2013-03-06" version="1">MELMLRLLIVVLLVMHVQCGEVKSSDCDPSRVLLNINNASEVLNKRVPVSIEDGTVHPVSPSDVVGLTMLICKTMMGFMQLWKHIDKAVKAGGQSYALDMSLAESKYRRSTLITEVKVFVELFSFTMPFPEPERVNRFKVHVDAMKFIKDRSLTEWEIDMQALVLYVDDFYTVCRVASNLCKCAFGAVSLCVRPEYDSFKRMLSDSPISLFNELEKLKVASRGTASACELKQPGEFIRWLGMLSRLRKAFVNYLMARSGRLRGVVEVCRVAKAVEKDIKELESEYNAYLDSQEGTIMSFLRSWNIIGEREPLFIEGILLRDVYKACEDKFVDSVESLRKKGNTDVVALMISLMESGGTYSLQLSRSREQFWEWREEVKKDKRSINVPLDNWICEFRLNYDSDFKSRDNQYEEEELFKYMYQTIAERVDKCWFNSTLYRVVKKKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXC9</accession>
    <name>L7JXC9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1353"/>
    <dbReference type="HOGENOM" id="CLU_1741858_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXC9"/>
    <dbReference type="OrthoDB" id="2190892at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="150" mass="17505" checksum="B95B35FF6131D905" modified="2013-03-06" version="1">MRLNGIVFKLRMFFNNINELINRISLKVKNVESKIVKFQLSDKNKKMLEKLNIKPTIGINNLLRKLFKVIHGLRQENGALENERSDILSFAKENGANNRIIKLIEEFSKEFEDARNGLNECRAYLEKKGKENKLLKSEIRKLRKCSKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXG1</accession>
    <name>L7JXG1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1393"/>
    <dbReference type="HOGENOM" id="CLU_3282350_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXG1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4748" checksum="3E96E7DCECB884A7" modified="2013-03-06" version="1" fragment="single">VFGQVLCMKEIIKLTFDYKMGRVYSGSEKRVWSGIVYEGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXG2</accession>
    <name>L7JXG2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="6"/>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXG2"/>
    <dbReference type="FunCoup" id="L7JXG2">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0915"/>
    <dbReference type="HOGENOM" id="CLU_001715_1_2_1"/>
    <dbReference type="InParanoid" id="L7JXG2"/>
    <dbReference type="OMA" id="IFVFTGP"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="200" mass="23818" checksum="EE95150144548F2A" modified="2013-03-06" version="1">MRPRTAPKSLYIFYIYHDCAKPMSKLVVVTGTSGCGKSTLIRRILNHENVSLSVSHTTREKRAGENNHIDYHFITKDEFMKMDRSNEFYETTFYDNHYYGTAKSELNKNEYVIIDCDRIGAAKFNEFNNVKIFFYNTKDVLYERLMKRYNNKEKAERRLQSYEIDMKTYREGNYKHSIFTDDLERNVKELETIIFGSNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXH0</accession>
    <name>L7JXH0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXH0"/>
    <dbReference type="STRING" id="72359.L7JXH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1593"/>
    <dbReference type="HOGENOM" id="CLU_018195_1_1_1"/>
    <dbReference type="InParanoid" id="L7JXH0"/>
    <dbReference type="OMA" id="WITFPPL"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="7">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="5">
        <location>
            <begin position="257"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="352" mass="39482" checksum="DE847ED21289D6E3" modified="2013-03-06" version="1" fragment="single">VPMQVQVPALHELRLETGKTPATLRVVTGSLDILGQELLTDHPYTFTGTLFFTTFHGCTVELNDDIALQYTSTSNIERIFDLASTLSGTYNVVGHGRCTFLQTLCNLCVRMGKKVLISEIDPAQGFLVFPGVMGTMLVENLVCYDDDVQNEKLCYFYGDTEIKNREYYDMLSSKVLSHTKHNDLHLIVFPNENVVQDEESSDNFVVVGDERMFHTIKSRNKEFVPCHGYTKKAKTNALIYNYFHGKTGRYTPFILSERLRIYSVGEKFVPPTSALPLGAQRKMNTCVATPTSAEQDSIVAISYAKDEEEVGVRPVAGFVLIRSVQPLTFLCAQTTVSKDALYVQGNIKYSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXR1</accession>
    <name>L7JXR1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0843"/>
    <dbReference type="HOGENOM" id="CLU_895917_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXR1"/>
    <dbReference type="OrthoDB" id="2190842at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031540">
        <property type="entry name" value="DUF5088"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17008">
        <property type="entry name" value="DUF5088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="311" mass="35290" checksum="EE8C9B22E37D3FD3" modified="2013-03-06" version="1" fragment="single">VRLLSSPFDVLSLSFSFLHSIEGRINYISILLRKRKAEGTFFLVNDKIEEFYLLRIGEMIVYLFNTSEKVFYELDAYDQVTLGNMRMIDTNVYVSTIFTNITKKGGSVANDHNCIKDAPSTVKNNLKAVKLGKKVDDVFISGAIGYHNLEVKIKEEIKVDGCVLNVEMVPFINIIDVELAAVRGLCNSLVINEMKRIRTRGYYLGIDEGVTVGYYEINGAKDSASKDVQNIEIAENVTNDDHQNKEQKGKYVLIGNSENISDVMIEMDIFDNLLVNEKASYDWVKKRIYTINAVLLRVDENNVLKIISKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXT6</accession>
    <name>L7JXT6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993912">
        <property type="protein sequence ID" value="ELQ75866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1180"/>
    <dbReference type="HOGENOM" id="CLU_628795_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXT6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="399" mass="45386" checksum="D31DD6FF9992AD93" modified="2013-03-06" version="1" fragment="single">VHPVSPSDVIGLTMLICKTMMSFLEMREHVINSSKADGGDEGLDLQLTGPKFLPSAFITDIEVFAGLFSLTMPFPEPERVKCFEKNVDVFEFAKKIDSSRCEVDMQALVLYIDDFYTACRVTNSLCRCAWEAIGLCMRPEYGDFGSLLSDSPTSLFDELRRFKTISIAWVSSSTLRQPKDFLLWLTRLNELRKLFVRYLTAKEERLRGLVEMCRIAKEVEKDIEKLESEYNKYLDNQGEEVGVFQDCLRTWGFVGGRGPLFIHSVPLVDVYRAWTSGFVSKVKASLECGNSIVIALMESLKENGGVMPPELAKRRERFWKWQKEAKKDVKPMNVPIKDLLCAFKSGDEAEFVFDKQMAFINLHEAITERIAGCWLNSSLYGGYKCIADAQRVYEGCVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXU1</accession>
    <name>L7JXU1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993910">
        <property type="protein sequence ID" value="ELQ75871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXU1"/>
    <dbReference type="STRING" id="72359.L7JXU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1166"/>
    <dbReference type="HOGENOM" id="CLU_023964_1_0_1"/>
    <dbReference type="InParanoid" id="L7JXU1"/>
    <dbReference type="OMA" id="HPNTIDY"/>
    <dbReference type="OrthoDB" id="2190844at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187:SF1">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="553" mass="62535" checksum="D451F3306BE25485" modified="2013-03-06" version="1">MNVRDSEANNPNLPSAEEIEQIASTRYTGLCSIYKVAPAEDRKLMCISGMFFLIVYIYSVSKDLKDAFVIGRQVAASISVLKVFWVPPIATCFSLLVQKMSVRMKNETILKTFLYAYATYFVVYAAFMLPLREYIEPSKFITIDLLSDDKMKYKDFLAFAASIMTFTSCTGTLHFVASEVWGTIVLSLLFMQLFNEVCPEKQFKRFVPIVYALSNVGLLMSAATSYIVHYLTSRMEYDQRVYFYMAVFLLLGAGTVALILIQRYLINCVIPVQICRDTATKHKVRSKEHVGFVEGLKLVFSTNVIVALCTMVLGYNVIIIMNESAYKSCQSEVAKREKKSTESSVLANKCFEEMVTAVLVMMFFVLPTRDAIKWIGWTKYALVTPIGAFVACVAVLGLAMVATGLAGENLSPVNTFMSRLSASPEELTGKVMRWEQFFGILSTAGMKVLKYVAFDISKEYFAKRIDIAYRARFRAVYDGICARMGKAVGSILQLIFNQIFNTLDIRRSSFPYLVLALVILCIWILSVVYLGKKYNKSVERDEWVDMNFKAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXX8</accession>
    <name>L7JXX8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="JH993940">
        <property type="protein sequence ID" value="ELQ75607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXX8"/>
    <dbReference type="FunCoup" id="L7JXX8">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1437"/>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="InParanoid" id="L7JXX8"/>
    <dbReference type="OMA" id="KEYCFLS"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="506" mass="57024" checksum="5F727F69E7D7E25D" modified="2013-03-06" version="1">MGKRINLISSSTSELKTDSLLSYMDDELENIKSKNDAMTSENLDNFFLLYERYLHTRNKKIDWDKIKSPPSEKIVKYPGDVKSGGHKLEVDDRNVKKGIDSSSSSIKDERRTLLKKLAVLKLNGGLGTTMGCVGPKSAIEIKDTSNFLDLCVKQVDTLQRTYDTEVPFILMNSFNTEEKTNRMLRRYKGIRTFTQSVFPRISANSLLPIDPSLGAKSMYPPGHGDVFISLKDSGMLDKLLQEGREYLFVSNIDNLAATVDFNILNYVVENDVDFLMEVTEKTRADIKGGTLIELDDKLTLLEIAQVPAEKKGEFTSVRKFKIFNTNSVWINLKKLKTLLKEKRLILDIIENKKNIEGIDETVIQLETAMGAAIKYFPKAVGMIVPRSRFLPVKTCSDLFLIRSNLFLEHDGFLTLSPKRMFGCLPLVKLLGKMYKSVESFDKMFKGVPDILELDHLTVSGNITFGRNVVLKGTVIIIADDESVINIPDGAILEDNILYGNLPIIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXZ9</accession>
    <name>L7JXZ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0655"/>
    <dbReference type="HOGENOM" id="CLU_1462330_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXZ9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978971" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="21166" checksum="1B77E9EB48F80E92" modified="2013-03-06" version="1">MVSTLVLVALMIHASVCRATNFAPTSTKSGHWRIRHDAKRCTSYYMQDSGYGFEYMRVYDKVGSEDDREIFMLVSGGLAANKCTEHFRALQYEGLVSTAVMQDDLAFRDSPLYFVEEAMAFADEKKLWLTGPGLDSWLKVTKRELDELWDVLFRSYSLQTRSLRDRPLIFIKSKDGNEQGSCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY16</accession>
    <name>L7JY16_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993863">
        <property type="protein sequence ID" value="ELQ76180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0854"/>
    <dbReference type="HOGENOM" id="CLU_1983122_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY16"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979234" evidence="2">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="126" mass="14440" checksum="76F9AEC1F0C7D2AF" modified="2013-03-06" version="1">MLFLLLALAMLAVAGLFTAVAGPKLLDMMKNMNNPSKDEKLDNEQKNPKNDESNDHENPKDEDLQNPDENENSDDVNEEDENPDDQNKEDENPDENENPDDQNKEDENPDENENPDDQNKEDRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY34</accession>
    <name>L7JY34_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor of the Forkhead/HNF3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY34"/>
    <dbReference type="STRING" id="72359.L7JY34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1076"/>
    <dbReference type="HOGENOM" id="CLU_769839_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY34"/>
    <dbReference type="OMA" id="GGYWCIN"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="3">
        <location>
            <begin position="120"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="120"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="360" mass="42167" checksum="D8C423353B1338C8" modified="2013-03-06" version="1">MTKHDDRNNVTEHDALEGMMLLKTCRKAKKPCLAILRGNGKCAWQFEIYHHKFQVKDGCHAATFYYCVLEKSWFIFPVTGLLQVDEEPIRAAIVLRSGSIIKIGTIMCCFDVKFTVRKEYKKLLVEIILSSAEKRLSLSEIYQKLLSDYNFSTEKNASWKNSIRCVLSESKIFYKIPKKIKRGRGGYWCINGKELAKMDEESIKKCEKRFFDSFIYDRINVVYTAIDLIRGQQDKHKENIEAYKKSQCEERIYNHVQLDECETFSPYSHHGKIARAPYNQKHKINYDIEVKKQKTDPWFTEIQNTSTKNPLFPSAVFDPFEYDDEFDALDRNGRHSTCIADELSSDFSCLSVKEKRRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY40</accession>
    <name>L7JY40_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
            <location evidence="1 3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY40"/>
    <dbReference type="FunCoup" id="L7JY40">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0821"/>
    <dbReference type="HOGENOM" id="CLU_100680_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY40"/>
    <dbReference type="OMA" id="KRKCNIF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="206" mass="23758" checksum="D81C797B1B421047" modified="2013-03-06" version="1">MSNLSSQIQLSSTLYQDLYALDSVETLIAAMRKRKCNIFLNESGNKLAVGRIYEDEVLDIIEYEIIEKKGFVSGGTALGSKYLMLFLGLSERERNLWTDVLYQRSSQINLDAIMYVFVLTRQENEFVLSLCTRDKLELVGPFYKLKVMREKYCDSALFKTALGTQKPKKMKNVTVDEQKTKVGKVYVNKQDFKDLRLKKGIFKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY62</accession>
    <name>L7JY62_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dynein light chain type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY62"/>
    <dbReference type="STRING" id="72359.L7JY62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0801"/>
    <dbReference type="HOGENOM" id="CLU_175762_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY62"/>
    <dbReference type="OMA" id="GFVENTY"/>
    <dbReference type="OrthoDB" id="2191060at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="12805" checksum="6AA8A1CBA0B0CFFE" modified="2013-03-06" version="1">MATKVEEKETKAPEEEKKKHLAKVVKSTCDQNVLEHCLNIIDKYKIKDSSPTFCKRMKDSLDSTFNKEWNVFIGGHFSGMCGFVENTYIELMLNDNMRMVIFQSYSPEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY98</accession>
    <name>L7JY98_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0730"/>
    <dbReference type="HOGENOM" id="CLU_1856704_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY98"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="138" mass="15781" checksum="6F80A641B17892B5" modified="2013-03-06" version="1">MYQPEHVEQVYFSEPPPGYCENMNNAQMYSHYCGKCGNECFANNQPANQHENADCTAEKAEDVPTLTENRQLNGEKLLELVISSLNKSETPVEYVNIYKDLTSTTREFDDNFSNFYIFNYTSLNIVNCVPVALPVDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYB8</accession>
    <name>L7JYB8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0755"/>
    <dbReference type="HOGENOM" id="CLU_2607714_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYB8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9799" checksum="7A26DF86730F39AE" modified="2013-03-06" version="1">MKAEKARKAEEKRRANEERQKAEKKERERIKAEERERRKNEQLSNQERIRKEREQQRNHDNDTDYVSVWGSSENQCRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYG0</accession>
    <name>L7JYG0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0531"/>
    <dbReference type="HOGENOM" id="CLU_903686_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYG0"/>
    <dbReference type="OMA" id="EVQVDCI"/>
    <dbReference type="OrthoDB" id="10327729at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="297" mass="35069" checksum="2962A79DE8982C39" modified="2013-03-06" version="1">MVRMFLPNVLLLPIYMLCLISVMFVSKRTFEFFFEVFSLQNKLIQSTYDPKAMIYIVEGNTNRKKVSDHLGKIEFIDVENKNFIPNGNFNITARIGYNFVFLYEDEMSMMPTKTIFLKQAFDRRMGFAELIEFIENNQDNDSIDDVKSLNTMLFLALYGYMSHFSLSVFENAIMGYVNHDIYFVIRINSPLQKFGKTENGEVSYPFIAKLVRATILAKNKNKTYSIQLSKKDLNIKNFLFFYIQKRNKIAEKIYEDIVRNKICFGLPEVQVDCIDKWKNMDYDLEMISKRSKIRFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYJ0</accession>
    <name>L7JYJ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small Conductance Mechanosensitive Ion Channel (MscS) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0527"/>
    <dbReference type="HOGENOM" id="CLU_474231_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYJ0"/>
    <dbReference type="OMA" id="YNTPLET"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="575" mass="68341" checksum="DDE4F8FCCA0F3282" modified="2013-03-06" version="1">MNALDPKNQEQIETLLDEQIFTKIEFQEKINDTIGKVVFYFFAGLVLLGLSLVPYYSLPYYMNQQIIRLVLYVSFYICWCVASFFIAESIVRLMRLKAFNLFYQSKFIIFLFKKQHFRMRVIFTFIIFSSLNFLFHRFMGLESVEEKYASFNHLLTKITVTLGLTLFCLFISGTIVDYLDFYSYQMNYKNRVKHNREVLKHIQKINRALPKEITNLGRYAAQLFDTIMHMSRSYNFDSGAESNAYSEVSKKEELNAENENVKTAIHEAENHENKSAEEENPEYEDKPKNPGKEKIERREAKKKKNNRNYLVREDFDRLFNEPEIFSLFDFDRNNQVTRHEFIKRYLALFEERERLKRALEQNSNNMVKINILISSLFVPFIVFILLVFTGHLPSFQNSFTMAGLVIFPFTFAFKSLVEEIFSSVIFVFFIKPFDYGDIFFVEGKRYEVLSIGILYTDFLLDDKFITLKNNFFNAAQIFNLRKSDFISTVYTFKFDYKSFKENEREFTKKLDEYFNDTPSNSYKIGNYSVERTTISVTLEVKNVIPYQEIDTLEERNDEFVLFVNNLIEELNITQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYJ6</accession>
    <name>L7JYJ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromodomain-helicase DNA-binding protein</fullName>
            <ecNumber evidence="10">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="10"/>
    <dbReference type="EMBL" id="JH993922">
        <property type="protein sequence ID" value="ELQ75812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JYJ6">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1231"/>
    <dbReference type="HOGENOM" id="CLU_000315_8_5_1"/>
    <dbReference type="InParanoid" id="L7JYJ6"/>
    <dbReference type="OMA" id="HWEREFA"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="401"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="886"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="690"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1435" mass="167677" checksum="40B73AE0ECB8D321" modified="2013-03-06" version="1">MPKRIEQEDSGSTESLSNITDESESENVSSSEEFDRQMVKRGRPRKMMNGVNKMNFAGPLGNYYQNPPQMPYQQSNMLYRNINPQRSNYMYNPGIPNSYRSMGYPSQLGPSNPSFIGNVSSQFSYYNYPQYRQAYPPQGYQQPSYQQPPPQYNAPYKQPPPFYNFYAQPAHQPPPPVQKYTPPMRVDRERQRQERLKKRKKVSPRPEEQPQNELFESDEMEEVEEDKHEKLLDSRGEMFFVKFRNMSYIHCEWVPREEIMKTRAGAIKAKRFLSRHKESGTSASFEEGRSIQQIIAEDFGGNPPFDPEYIKIDRVISVDNLILVKWKKLAYELSTFEKIEDIRELEGFEEELREYKVRNVVKKSAFPIDYRPPKDALVISKPFKNGNTLRDYQMEGLNWLLNRWYYKQGCIMADEMGLGKTVQTVCFVNKVFETGYQHPVLIVAPLSTLIHWEREFRTWTDLRILLYHGNNVARDLIYDYEFYNDGLLFDVLITTYEMVMSGMKHLSFNFGIGVFDEAHRLKNSHSKAFQSLISLSFNHKILLSGTPLQNNLTELWSLLHFLDPIKNESLSYFLESYKLEKSEDVDRLKTLLKPVMLRRMKDDVEKIPIKEETIVEVELTMIQKQFYRAIIEKNLSIFEKESPNLLNVMMELRKCCIHPYLVRGAEEKIISDYKIRRRIDFIKQRRMLGEEAEDGFARKDEAGGEVKESRMESGESNKEGSKEENRESRLDTPKEKSKERSRDNIAENPREYPEKEREEYPEKQREESPEKQREEYPEKEREEDHGDNPKNDVIVPITKDGITEGNVANADEHVVPGANNEADNAQAHVAGAVNKNTEKCLNGSVRVHGTAEDDAEGAWRRETPTNELTVDEYYKILIQSSGKLVLLDKLLAKLKGEHKVLIFSQMTRCLDLLSDYLQYKRYKYERIDGGVRGECRQAAIDRFSSAESDSFVFLLCTRAGGMGINLTSADTVVIFDSDWNPQNDLQAQARCHRIGQTKSVKIYRLITRNTYEREMFDKAGLKLGLDQAILQKNKSVRKKEHIENLLKKGAYGVLMENDEAAQKFCEEDIEMILERRTHIVRHNQEANQNVFSRASFQVEEEFDDPDFWQNLLSKRKDAENEMKIKRLIRRLGRETPTDYEEIDRVLESTDDEMVKVFLTIFRKGVNGIIENVSDVKEKIGILVRYCYETLTDKNKEDFKLHLEAYFKDDKQLPVDHHIVKKLAEKFLLRLQVVSILKYLYRIESLEHMKGGSVEEDRRIVNWVISNGYDNWPTGVGREKGLFRGKDRNDLNARVRKIILSLNKIKENREDREREIEVDNIVMNYGRVTTLNENDIAENIEEVNKRVEMVMNQKRRKSNLESLYKRIALIDALRTLEVEEIKRTVGLPRGWKKKDDERLVQLVRTKGIANTAAELGLSDEIVVRRLEMLVSNENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYM3</accession>
    <name>L7JYM3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retroviral ribonuclease H, LTR Retrotransposon</fullName>
            <ecNumber evidence="2">3.1.26.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.26.13" evidence="2"/>
    <dbReference type="EMBL" id="JH993917">
        <property type="protein sequence ID" value="ELQ75842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1194"/>
    <dbReference type="HOGENOM" id="CLU_1699800_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYM3"/>
    <dbReference type="OrthoDB" id="2194934at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="155" mass="18395" checksum="F4DA88E493198A04" modified="2013-03-06" version="1" fragment="single">SQGVKSSPNKPEFDNNRLNWWYRTIQQYDFTIEYGKPINLVKADALSRKHEKVKEPTEVNKKTVKRHETINEKHLFAVDGKKYCRFDSGIVRGVPESENTEKLIIEAHLKTNHRGLVPIYYELKERYYWLGMKRHITEIIKGVRRVSGMRGTHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYT5</accession>
    <name>L7JYT5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993904">
        <property type="protein sequence ID" value="ELQ75917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1125"/>
    <dbReference type="HOGENOM" id="CLU_1582459_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYT5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="169" mass="18664" checksum="DBDDC5C8F9A9F19A" modified="2013-03-06" version="1" fragment="single">VNTLRVSGNEFERGMDVSGDIGTLSEICFGKIINRNMHSTDGSSPIGRELMSTSGEHVPDSRGGNAVPGSNWSNRPAYTNAVPFNRTIPMVNSTHSFTNSSIHFNKISFNCSKDTSPINPTKLKHKRQCDTCLRYFISDPFLKYMEYNDIVLLFALCSAKCGNGFIDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYT8</accession>
    <name>L7JYT8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0314"/>
    <dbReference type="HOGENOM" id="CLU_083680_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYT8"/>
    <dbReference type="OMA" id="KFICFEI"/>
    <dbReference type="OrthoDB" id="2189795at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="305" mass="36198" checksum="36F8ECC452ABC469" modified="2013-03-06" version="1">MDIKKINKTIKLLKRCYNQPILFQILHNNLSFLIQNEYNFPFHLYPDMFSKILIASTSTQAYVNLDNKILAFLKDSRESVKYSVITRYKVKIILYYLINQPYDMFSKFICFEIINNYGNIPDLGYLVAHYIRKYALSNFFEVKLKKAMPIEYVDLYLQKNMGDSVDFKAEILPLCAIYSLKGISLGNFKFDYNLRSIILLESVTFYAKFTENVSDIKRVLPSNDNFVRFFKIFLNRNKPQNREIRDGDSTSLKELDYRTLMVYDNLLFKSLKEEFVLVDDKREYLNKLKEVVDELEKSFKEFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYY8</accession>
    <name>L7JYY8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JH993893">
        <property type="protein sequence ID" value="ELQ75977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1051"/>
    <dbReference type="HOGENOM" id="CLU_285932_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYY8"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="836"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123174" checksum="1AF4BAB44BEDA732" modified="2013-03-06" version="1">MKQQQSIISSQSTQKHKYLYFPILAELRTHIDSILRRNLHALIITDTPDHVPTSTTCTVCTSAARNTYDSSRYDVLIFYGVHDPLLVLSTHHKNAYYLTCSPFDVIRVYDALGVRERCAIYVSNNTFYLSYFNHNKLLLYDTGSTGALLEHVKHNADVHAVVQPYVVHDVYDTQLVLDELMDRGRALDINLDERSINSVRAHAYTSNKLKVLELVLKRFSCVLVKNAFIKRAALRYLCMHGVQCTDGDLPVPDASAKRIALHVPQHVKYCVLDMQPIQTSTLVLVPSNTHDHIRALLTAEAKIRTLSVKQPQCTPAEISAMHKSALMRIENAVKVSFNGKSSTSEHPSTPNTLCVIMPMSSKDVLTRMNMRYNVMNESVVFKVDSCMSAFKVCAAAHTSADVVVQRKKNGFLRVSDLVVGHFVDRQVFADRYDLQGEGSLNFYDGLLVLEYLVGFKEGRDGVRSDGKEKGGSERDGKERGGISAHGINSSATYPNPKNPNNPNSNPNNNNHTNHKNPNLNNYFKNTFRPDTLHNKILKFEIKYKKIEQVVLSLTKEGQNHFINLWFILKEYPSLYVDDSTATLLDVPFVEHRYDICVRNRVHNVSFLDNVLEMVGCIGMRVRIAQVVFERGFTVEEVIRGLCEEDKYYVRCLYSSKGRIVANRLYYDENEGNVEVYNNGDGSVDSNRDKVYNNKDNNNNNNKDTNLNLNKVSNLNTNLNLHKNLNKDSNLNKNLNKNLNFNKDSNLNNNLNKNLNFNKDTNLNNNLNKNTNLNNNFDNTAWIKNKYKINLYRIKCIKEFCLAQEVLTARYSAFNTYTPTVERFTNPHIQPIRTVHVYPLSIACMYPKNNLSNRILRNFSNMIRITFKNTCDENVMEYIREIMSNGITIDRPYYFVATSSSQLRSNSAWFISPYRKGNVLVGSDYVRNWMGVIECDNIGKYMIRVGLGLSSTFSMFEVDDYVEEDDIVTYDGRDGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSPYLPLLLRTTNTSGLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ83</accession>
    <name>L7JZ83_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0668"/>
    <dbReference type="HOGENOM" id="CLU_893009_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ83"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="312" mass="36514" checksum="8C863AD1759777DD" modified="2013-03-06" version="1" fragment="single">VIYLISSSSIDEEVNLSVIPHHNDNLILLATAASTCDPKANRSQEFNIPRMEPQVSHDIEAYSLQNPSNVIENITRKSQNFANMNKSRKILKLLFATWQDRENLNLQNEKNRKDYYTDNNVSFNLLVLKKRLIDFREQYKRYLQLKETGHKQISKSVKHGLLSPSENSQDSAHDSIQTKKRKTDDGNDNSQNSQKNIIIDSEYKENISRLREKLMETIICIDKIKKEDIIELDLFLKRHIIFIAEPSPEIVEDIKIEKVVQFYNETEKHIKFSADYFLGLVCLERFIIFFWVVSDYFSKRGLPVSVCYFQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZA8</accession>
    <name>L7JZA8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA modification enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZA8"/>
    <dbReference type="STRING" id="72359.L7JZA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0227"/>
    <dbReference type="HOGENOM" id="CLU_486797_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZA8"/>
    <dbReference type="OMA" id="CYVIAND"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978907" evidence="7">
        <location>
            <begin position="27"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="8">
        <location>
            <begin position="276"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="528" mass="60736" checksum="5183AC95228EE7F1" modified="2013-03-06" version="1" fragment="single">VFICTRNTPFTIFIAALLQPMHELFAVPLKTGEIEDAIRKYAHITFKKKGVPRIINADKHYNGFVVRNGNDVRMEGKYLLVSEYVEGSVGVTLSVKTEDAFDRFVVKVGERMKRENYDVEEICSMEDNGKKNYEKEEICSMEGDNGKKDSHSAADECCCTRIGEYGMVSKEKKHHDDETGTKQEIENNGEVNDDDRKYDTIKRTKENGSFILDHFCIGVGKINDKYVRKSRCGTEENTEGQKERVLQQNCSSPQHTNSIRSPRVEAFVQDLLPRSFEVLGKTLILNLSDDQKKYKTEIAEYFIDLGRYKTIFLKKDVVKEPYRTTEYELLLGEDSKDVLYVENGTKFAFNIGDVYFNSKLSGAREQLVNKFRKNDVVADLFCGIGPISIQALKRGCYVIANDINPKAIESFKNNLKINRITARHEVHNEDAKDVLLSLTDRVIEHFVFNLPELSIYFIKYVKAFTNSELHCYFFCRKGRDVFAYLREEIGLVAPQGCIKECRNVAPSKLYYYMGVEIKDLRWLEDGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZF1</accession>
    <name>L7JZF1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cdc2-related protein kinase</fullName>
            <ecNumber evidence="12">2.7.11.22</ecNumber>
            <ecNumber evidence="12">2.7.11.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="12"/>
    <dbReference type="EC" id="2.7.11.23" evidence="12"/>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZF1"/>
    <dbReference type="STRING" id="72359.L7JZF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0161"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="L7JZF1"/>
    <dbReference type="OMA" id="FLCVIGK"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="316" mass="36983" checksum="106DA1A3B7037F99" modified="2013-03-06" version="1">MDRFANAQMIGEGTFGKVYVANDTKTNTKVAVKKIKLEKNGVSLITIRELKILKLCNSQHIIKLYECYIADGSFYMVLEYLPFDLSALFLSKYRFSDDQIKNLTYQLLHGLSYLHERGIIHRDVKSSNILLTHDGLLKIADFGLSKYECRDMTNQVCTLWYRAPELLLGENNYDNRVDTWSVGCILLEFKVLNPVFSENNEVLQIARIFKLLGAPLRTYKYSSLFEQEKYVVELPWGEIIERNFGRYFHPDFLYLIGLLLNLDFSERISCTDAMKLPIFNECKCNYTKIELKDIHDTIIRSKLRERYKTRNKQNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZG4</accession>
    <name>L7JZG4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0587"/>
    <dbReference type="HOGENOM" id="CLU_3207931_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZG4"/>
    <dbReference type="OrthoDB" id="2194934at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="45" mass="5484" checksum="38522788F151A666" modified="2013-03-06" version="1">MVALKWGIEKLSYELKARKFHLITDHKVLEFIRNKPEFDNNKLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZI5</accession>
    <name>L7JZI5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0575"/>
    <dbReference type="HOGENOM" id="CLU_912721_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZI5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="305" mass="33996" checksum="B9E47BFA2E9A5D0F" modified="2013-03-06" version="1">MRSLFRFVMLYLNLIALILVLNIIKSSTVSDGEKVLGEDTVYPSDTHGLFRRSVAREKGGERTQMLSRINDIDTCPFCKCGNRKEINDSDAEDHENEQLLGSGDKATKETEAMDKVRDDISTLNSVRDTDSQILVCEVKSLGEVIGSTHNDQLDKDLEFEEYEGRGTCSTGDYSLDKIGEPVGIQNQVITDEPCSSKFNHVFEAELAQDYSTSEIDSKVFHNESFNDLSNRMSTGANEFKDKGSPDFNVLLGSKENINLSKMMSCSGTSCNSKNENCDQVGYCDSVSEASFIVFMMLVLLWAIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZP8</accession>
    <name>L7JZP8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZP8"/>
    <dbReference type="SMR" id="L7JZP8"/>
    <dbReference type="STRING" id="72359.L7JZP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0110"/>
    <dbReference type="HOGENOM" id="CLU_618451_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZP8"/>
    <dbReference type="OMA" id="APDGHTH"/>
    <dbReference type="OrthoDB" id="2196078at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978929" evidence="3">
        <location>
            <begin position="17"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="443" mass="48134" checksum="706C8D8E52B50B5C" modified="2013-03-06" version="1">MLLLIFSLFLTILSHSVNNNGSGFTHGDVPDGLYDVNGNMGGAYYNHQGLGTHSGDIGVNGILFTADALHHGGDGEIFVSGPAADQENLVGMGLDQLHQKMASDIAVMHNANIESKKKQMEAAMLEAQIAQEMAEAKEEEISRLKYLDDVAEINEHKDPEVLGKQVIPVATFTEETMPLRHHVRYLLNMIKSMQDTENANVEAQRKIARLDDITDKFKPYNAVFSDAQRYRAFQKAAGLDGYFPMHFPVTTINGNFYVSHSGNETHDHDKVMNSPPAPDGHTHFSNHGLEASPVPTVPASVATIPPPAMSSSSPALHSQPPLQSTSPFHPLTPPIYPSNSALPFPPPPTPLPHPLAPPPSPQISSPPPPPALANPSNKVTHPKPNRHPIPSRSAPSPPPRTLPPLSPLDQINKQQEEGRRLASMKADYIRSLTRPVLPSSSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZS5</accession>
    <name>L7JZS5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993839">
        <property type="protein sequence ID" value="ELQ76546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0474"/>
    <dbReference type="HOGENOM" id="CLU_2795741_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZS5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="68" mass="7790" checksum="ED61038A58610FC4" modified="2013-03-06" version="1">MLRINYERPSAKELHRNLKKLSKSATVKLSDELYCGFIIPDNNILVEQADYIFVKIDAADAAKYLDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZU9</accession>
    <name>L7JZU9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0158"/>
    <dbReference type="HOGENOM" id="CLU_1826770_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZU9"/>
    <dbReference type="OMA" id="AGQHKES"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="141" mass="15818" checksum="9A9B08CC2B93770A" modified="2013-03-06" version="1">MKFEVALVLCIGFVIFIIFFIAAVFPEHKQEESPDRESLVTTIVNLTKQISEDGVKLGEKLKDKDIREAAIIIKRYIQIKEQGGELNEENIGHLFKSSGKLGTALTEAAKKHKKSKNDLSKLIKANDNLKNSLAQLQQLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZW1</accession>
    <name>L7JZW1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZW1"/>
    <dbReference type="FunCoup" id="L7JZW1">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0727"/>
    <dbReference type="HOGENOM" id="CLU_051385_3_1_1"/>
    <dbReference type="InParanoid" id="L7JZW1"/>
    <dbReference type="OMA" id="VKPYHNE"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16887">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="6">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="164" mass="19313" checksum="C3E0FC55BBCD5E3A" modified="2013-03-06" version="1">MKRVEDVNITRSILIGTSATLIKNPTTDNTHTWKFYIKSPTNTPMHYISKAVLTLHETFKEPVRTITHPFILEEKGWGEFNINVKLYFNDLNEKFITFSHFLKLYGENNEDIVVNEKRETIVFRSPSKRLYDMLGDEEMCDDGSDEERIESALRYVLKKYEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZY1</accession>
    <name>L7JZY1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TatD-related DNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993809">
        <property type="protein sequence ID" value="ELQ76875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZY1"/>
    <dbReference type="FunCoup" id="L7JZY1">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0134"/>
    <dbReference type="HOGENOM" id="CLU_031506_1_1_1"/>
    <dbReference type="InParanoid" id="L7JZY1"/>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="271" mass="31223" checksum="494EE5D50A710E5C" modified="2013-03-06" version="1">MFIDIAFNITHYKDKEHDDTIQHCIQNNTMPIFVGTNVDTSKECLRLAKKYHTMCYSGIHPTESGRCSGTNELPVDDCSILALGECGLDYDRLEYASKNDQQVVFKNMLAFSYTNYFFHSRNAHNDFLSIVKQRKSGVNGIVHSFTGTKDELVQLLDHNLYIGINGCSLKNKTDIFEVLPLNRLLLETDAPFCCVRKSYYYWNDSVPKIRKYRAGDVKIIYDLVSGIYGIGRDEMEKIVEDNLVRIYGNRAREGIQKWKTYMKKTINGDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7K095</accession>
    <name>L7K095_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophosphatidic acid acyltransferase LPAAT</fullName>
            <ecNumber evidence="3">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.1.51" evidence="3"/>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K095"/>
    <dbReference type="FunCoup" id="L7K095">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K095"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0200"/>
    <dbReference type="HOGENOM" id="CLU_041302_0_0_1"/>
    <dbReference type="InParanoid" id="L7K095"/>
    <dbReference type="OMA" id="ELCIIMK"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="351" mass="42000" checksum="CB10F1BAFACD3604" modified="2013-03-06" version="1">MLWTKIYCFAKICSIAIFYFTLSFYVGTLLLLIRLVLRPFKNARSRFTKIIKGYWLSLTASVCYFYFPHPIYVAYNKEILKKKRCLIVSNHLTNLDWIFIVVILNELGMYEELCIIMKYSLSKLPIYGYGMKCFDYIFLKRRWQEDIHILSQGLEKMKKKENFYLLFFPEGTILDSETYEKSQKYGRDLNMTIDGRLYNPQFCLIPRVKGINKIYEVLQEEIDGVIDITLFITPYKRYLAEYYDYCDVLFNLQRIPRFYIVLDEYKGKMNGEWLHRIFDKKDKCLRGVVTRSTSVENITCLADFAKLFGGLYQKKFNYFGKTMWSNNFYLNLCAFFIICASNIYLLKKLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0C7</accession>
    <name>L7K0C7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0C7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0097"/>
    <dbReference type="HOGENOM" id="CLU_1016314_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0C7"/>
    <dbReference type="OMA" id="CPEKGGV"/>
    <dbReference type="OrthoDB" id="10471690at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="274" mass="30324" checksum="F3FCF50FF8C8D34C" modified="2013-03-06" version="1">MTSQTSLLYRPINKTRTGDPMHIKPSNIHKKEKLEKDKFTIEVTLPEHVTMKDVMLQYTDNSYRIKYAKGYEGARDGGRYACATSGCIEGTLPFKIEEPMSVAKEDGFMLVFKRGGAVANQLKSVRVSELCGGKKDKEICDTCGQSKKEDEEKKKGKPCPEKGGVCSEKGKPCSDKDEPCPCPEKGGVCSEKDKPCSDKDKPCPCPEKDKPCPGKDKPCSEKVCHDKKKNGQADSTSNGKKKSKGEHTTGDSTGSECNKERSRDEERRNGKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0J9</accession>
    <name>L7K0J9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0J9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0149"/>
    <dbReference type="HOGENOM" id="CLU_2504101_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0J9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="86" mass="9991" checksum="5FC9C8C6BC83A51E" modified="2013-03-06" version="1" fragment="single">VMIRVFYWSYVGQFAIFFARFDGPKTMVADFASIVLLGIIIVIYNETINLEIGWLRITCNLIIIFTTVYYITFNVLTAIQKKRSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0M0</accession>
    <name>L7K0M0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993799">
        <property type="protein sequence ID" value="ELQ76967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0M0"/>
    <dbReference type="FunCoup" id="L7K0M0">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0M0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0030"/>
    <dbReference type="HOGENOM" id="CLU_000288_77_0_1"/>
    <dbReference type="InParanoid" id="L7K0M0"/>
    <dbReference type="OMA" id="HHWDVKS"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="383" mass="43328" checksum="03DAA6DC69D48D2C" modified="2013-03-06" version="1">MAINIKDIVSARFQNPKFQYDGKRMRNLATRRALDYTKYLLPLSLDTPRTTVFHQHAEHVSINKMRCPINIVRFTPDGRRLISGTSTGEFTLWNSFSFNFETILQAHESPVRGLEFTRLGDLLLSADTTGTVKFWHLSMNNVGIRQCHEEAIRDMSVADNYFVTASDDSTVRVHSFEKNACVVLRGHNWDVRVAQYNPVSSLVASGGKDNLVKLWDTRTKGCVATMHCHKNTVLCARWIDDMNLLTAGKDQVIKQSELRMLRDNFTYKCKKEVTALCVMNGCMDSSTISSASTTNFSCNSPLRSGLFAAGMADGSIAHLQTFNQNMCVVSGHESTVWSIDYHPIGHLMASGSMDQSVRFWSWRKEEINEEIENNEERIPGLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQW1</accession>
    <name>L7JQW1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3264"/>
    <dbReference type="HOGENOM" id="CLU_1240899_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQW1"/>
    <dbReference type="OMA" id="KTEMEYY"/>
    <dbReference type="OrthoDB" id="10568907at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="223" mass="26384" checksum="549FD760277B4FAB" modified="2013-03-06" version="1">MFLFVFKYVIASYNFDDFYDDYYDNYLYDYRDFNDYYPFVYEYPEYPQIAGNYVESAKEVVQERVQPTVAEIKESLLPVIPEVKSKTISPAITVPSKNELKKMVEKRPVTDTENKAKETKSSGKQNKKRSAKKSTVKKPKKEEKLEKGKFDNKKYQLDHELLKYIFISIAVIIILVGGGYLLAMYIRHRVMGKTEMEYYRSLTRPRIEPDNEASQRRYAIRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQZ4</accession>
    <name>L7JQZ4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">THOM_3171</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQZ4"/>
    <dbReference type="STRING" id="72359.L7JQZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3171"/>
    <dbReference type="HOGENOM" id="CLU_027449_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQZ4"/>
    <dbReference type="OMA" id="SHVCIYL"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="341"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="341"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ELQ73893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="658" mass="73404" checksum="FAA230F9E18C5CE0" modified="2013-03-06" version="1">MNDRYRQLFYSSIILFSSYFSYDIPAALNKNIHLGSTKFSSYEITMLYSAYALPNIFVPLIFTFVTEYSESTLNVFLSFLVLAGQCVFTLGIFKGVFYVSVFGRLLFGIGNETLFVIQSKLITTTFKGRELAFALAVFTSLGRLGIVFNFLITPYLAKRYSASVPSLIGLVLILVGLVLNLLAKRRPLQIYQAELSTSEPVRVHNTDKTVVVVPDVEHAPQVRVPEFVLGGCFFSDEANVWGGECLMKSKPMKLPYRTEPPTFIRTRETSTAECEVRDELKKGIRFMNDDDCENLWSGGNDTLNEDDVACNNNINKLSVDCVKESYRASIYEKCYDNNDRSSNIDGNNSNNHNSNNTNISNINNINNTNNTNNTNINNINNNNVNQTSISQSNNTRSNDRSAGHISDSCAFFNRKNCAQQTIKTASIAHQNAKESTSITPHKISFDEINRTTHIPIIPCTPEKHTISPYFSILVLIAFLSAFVWAPFYNLGPLLFQKRYNYTREASASMMGVLEMVQMVTIIAIGVLSDFTGIKLLFVALGALLLAISHVCIYLNCNVVAVICTLGIAGPLHSCYWPCVSNLAAQERLSFAFAVISSFLNLSFTVSPLVASYLLQIDGSFRLIEGLSVVFAVFTFVIVLVLNFIDLKKKLGMNKRQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRA4</accession>
    <name>L7JRA4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallopeptidase</fullName>
            <ecNumber evidence="7">3.4.11.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_3109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.11.18" evidence="7"/>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRA4"/>
    <dbReference type="FunCoup" id="L7JRA4">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3109"/>
    <dbReference type="HOGENOM" id="CLU_015857_7_0_1"/>
    <dbReference type="InParanoid" id="L7JRA4"/>
    <dbReference type="OMA" id="GNGWVYD"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="37"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ73969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="328" mass="36322" checksum="3672B8A6781C03DF" modified="2013-03-06" version="1">MTVKQKLSELPIELLEKSCHKPGEVTGKTLQTDVLENARRAAEAHRRVRYHLQNSLRPGMSLSEICDLVENSTTTLLKGELNDGLGFPTGVSLNDCAAHYSVNPGDQDIFLKETDVLKVDFGTHVNGVIMDSAFTVTWDPRMDKLLEASKEATEKGIKTMGVDVCVSEIGREISEVISSYELTLDGRRVPIRPVANLNGHSIKPYKIHGGVSIPLVENNDSDRLEADGFYALETFATTGNGTVRDGPNCSHFMLTNPNKFAVSNPKNVKVLQIIKKHIKTLPFSARFIDRYFDFKTSSLISLKNLAMLGLLEPYPPLHDIKRLACKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRC1</accession>
    <name>L7JRC1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3124"/>
    <dbReference type="HOGENOM" id="CLU_912725_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRC1"/>
    <dbReference type="OMA" id="MENICDY"/>
    <dbReference type="OrthoDB" id="10523025at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979058" evidence="1">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="305" mass="35438" checksum="0C298D7E17202BEC" modified="2013-03-06" version="1">MYLSLYLFHFVVFASAAEDTSHAMTLCCLESGKFCESVSTDQYTSHSIRERVNEEIKPKLKAVKEKCENIYKVVSTCEVEHFRVNTSLILSLYGIITDVMARSWEDEAKLVIHFVYYVQEILLNAKYDTFNLYQPTDYQFSQTYYDLYLRTGNNFRHVINKYCLTNLQDDQNWHIINASVDFMENICDYLLTIHCDVQSAMRFSIKFFTLNFVNQGLVFLNKIISVFVDGYQTSYMTEACLCGVRIITSRLYVASSNEHTLCTLCLMEKWMGPQENLTGCASENIIKKFEAFCTHKSSNKKNEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRZ9</accession>
    <name>L7JRZ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3027"/>
    <dbReference type="HOGENOM" id="CLU_3178062_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRZ9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="47" mass="5155" checksum="85973D4EC0CBFF75" modified="2013-03-06" version="1" fragment="single">VKKNRSVAESATKKDIINGDARNIGEKIKRILSIYIRSIKGVSKQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS80</accession>
    <name>L7JS80_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3184"/>
    <dbReference type="HOGENOM" id="CLU_1134286_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS80"/>
    <dbReference type="OMA" id="FRELIVI"/>
    <dbReference type="OrthoDB" id="2189356at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="245" mass="28740" checksum="D517FF23C04496BB" modified="2013-03-06" version="1">MLLLINLTACLESIYDPNFMKNDVYYGYDKKGFLTNYDKDSIREYDKDEWDKDFVNDFKDGKEYDDMKDNVDYNDFKEYDGYSEYKDTFNNPYTTPLAYKLSPVTKNIHYNQLATYPLQQSFSRSILFANKNSLPKILSREFNDISKDLNKKLTNSIYNVRNSNIDHDKFRELIVIKKRVVSDGKHKVVNLDVSGRVVPRNGKEDKLRMMLAGIVFLLAGVIFTGSIKFYQNYLKIKKVDSLGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSA1</accession>
    <name>L7JSA1_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">THOM_2721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2721"/>
    <dbReference type="HOGENOM" id="CLU_2322003_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSA1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978788" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="99" mass="11024" checksum="B7F5D71084412684" modified="2013-03-06" version="1">MNIKFAVRLVILSLGMIKGASNEEECKSKEMSMLVTAENAKHSLNQKVQLPLWDCSKDVISTTVSEFTYRAIGLRMMEADLLFKRVNVCAAVNDPSGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSB9</accession>
    <name>L7JSB9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Armadillo-like helical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSB9"/>
    <dbReference type="STRING" id="72359.L7JSB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2674"/>
    <dbReference type="HOGENOM" id="CLU_1754190_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSB9"/>
    <dbReference type="OrthoDB" id="9398340at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="149" mass="17172" checksum="402EEDF74323C2EF" modified="2013-03-06" version="1" fragment="single">VNGTLSNLKDALPGNVNDHQTVINKEESKIDFKELTMDLSLIKDRAIRTSAGADVHGALKHVIYLLSKDDNKVRVHLVHNMAVLTIFGEEYVHEVIANLLRNMDDKNWRYRIALIDGLCMVDDIARYAQYFENDDVYFVRKYFRMVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSE9</accession>
    <name>L7JSE9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2861"/>
    <dbReference type="HOGENOM" id="CLU_3387205_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSE9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="33" mass="3894" checksum="7FBE6EDA71D6A981" modified="2013-03-06" version="1" fragment="single">VVRSVYYDNNITRYKGIGEILKKAMVDENMELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSG3</accession>
    <name>L7JSG3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3084"/>
    <dbReference type="HOGENOM" id="CLU_3130053_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSG3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="5675" checksum="52057EC457585AAB" modified="2013-03-06" version="1" fragment="single">VEVEEVSGHQQPEEVEEDPEEDQVRDLAPVQALALVQVLEHQRAEAPFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSJ0</accession>
    <name>L7JSJ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994086">
        <property type="protein sequence ID" value="ELQ74016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3067"/>
    <dbReference type="HOGENOM" id="CLU_004199_2_0_1"/>
    <dbReference type="InParanoid" id="L7JSJ0"/>
    <dbReference type="OMA" id="NCRINTE"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1506" mass="176002" checksum="236B053152502D5F" modified="2013-03-06" version="1">MNFNLSQPTVVVTVFVLLFNPKYEEKEDSQNDYLIVYDRSNLLIEPEDWIIYGEWNDNKSVRHLCYDILESEIAVKPKSDSHGDNMNNNGEDTKTPTNPSSQNNATFVTYRVITLPISKVLYEKILHLSWASDTRFTFDEICDLLTMLPRFFDKEALIMFCVFKTIVNDTNLFLKLNQFFSENISKQGNTCLSHRLNWYDDVRMCFYENGYLVLKDQFGNVIRTADDYEQQYKVPIYIDSTSKLFPPIPANYLAVDYKSLQNSSFDLSITYHKKSGLTLDIDFTGFFIEKNVAETCTSVTEDRIQSERLNDFYRLLNNPLLSSEYVNVIVLRISSVSYNFNFDFILTKEIHLYCDDCIFGDKIRFPVNLTILIINNSKINTKLELPQRLDMVSMKNCRINTENSLFINENYTEVIFCGVRGNIFLPSNWNLQAIEFRNTVNKIINVRKNRNGFFEIFRILGVKINDDIELGRNIKVFHLENVQIARNVTFKIHRSYENITLKNCAGRFDLTDFAKWLKFEIEKNWYDFSLTIKTERNKCKKSIKSIELYMDINQTAKFEFFRWIMTNDKLSSQNDNNYDMKTQYHISNSLELLFLYYIKVISGFKPSYNSNLYLSVNEENSVLTVRNIITHKNVLIDGFKKISLDGVKTADDQVLKITSKYSSLILEYCMGRFVVPGIQLGQKEYLYLYKTNFIQFYEVEEDVYSFQMRKIGFGDKLLIWHKIRTAQLTNSELCENIGLEFKYGCEILHLTNTKGVIISSNNRFKRIILRGYDQSFPTYYVSYSAYEIIISSCHIDHHALVFTDSTKRIQLYSVKFTKHSIVIINHECENIIIRNTTGHFIISNIIKTSLMHEVILYLYYGIFVFEKNLAKNQLSLSLERVVIEKCTNIRENIHMISLTAVTLHKHVVLRINDDCEVLSIESCNGNIDFSRCTGLKSLTIKNYKFIYHKNIYDNLLSLHLENVKINTTVRLGKNIKTIKLVEVMIGWFKSIQICGNCQTVYVCDFAGRLEIPSIFNCRSKIFTQKTMTITYEVISGMFGRTMFLDNVYLEKDYEISSNVESVILWNFRTHGDVRLKINEACKYLKLNVYRGCIDVSKTKYIEKVIFLRCLPTFGDDLWEFSRSCKRPIDVTGKRKINLPNNIENVIIKKVKVASSHLVVVNENCQSVTIISSEGDFDLSKVRKLKAIKLLDMKQGLINIQFPDLNNVTTLEVSLSGDAKYFNLLLSKCINAKKLVLYNTVCELHDWIQKESLLSYREEMIPWRLDELKSMVELESHIHPCRSARELISDFIIHSKPIFDHNRQTIITDLSIIAFQIDNECLKQLKRFVMLKRLSIVAQITSDNLFDALPFSIHDFSLMLIPCYITPNLKIVAARNLGLKEKNTKNVRLINFQLDGFFFINMDLFRSFPQKVDVLEVMPLVKVNDIKMRVGKKMKVRRLIIMEMNSRTRDLICKDWILEEYFDHLLNVFSEYIDFGSVEEIKILDRDTEKLVDPRNYSTNQQFLITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSJ7</accession>
    <name>L7JSJ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSJ7"/>
    <dbReference type="STRING" id="72359.L7JSJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2637"/>
    <dbReference type="HOGENOM" id="CLU_984145_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSJ7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="283" mass="32291" checksum="C6BBC93D13DA446C" modified="2013-03-06" version="1">MDHTIKEQPDKNLVEINSLALSYVEGDEIENVINFSGFRFEIQTDTFSMDCFVRLSLFFTSNNVFSGLSFVSSVDLRILASHRLIDRKEELSDSFKRIKVNGKHKVDLFGLLSGDKKTPWYKQLADNSCYIVEGIREKVHGMLSKNSYIGINDYFIKNMISGGTAITFTFYDKSNDEIANVEIDLRKFVVFYSKTYGIYVDGLHNSFNVDILGLGAFSEYYRVSCTSSSLISQFIRPFTLFGEFAEKQIIKPENIVMGDAQTLACIKLETSHGLGDKWYFTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSK5</accession>
    <name>L7JSK5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3059"/>
    <dbReference type="HOGENOM" id="CLU_3335901_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSK5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="38" mass="4216" checksum="329D6FB5BDE1E648" modified="2013-03-06" version="1">MVYLSGTEGFLCVERVAKINAMVGAQRARRVCLVCEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSQ3</accession>
    <name>L7JSQ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2603"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSQ3"/>
    <dbReference type="OMA" id="EHERNDY"/>
    <dbReference type="OrthoDB" id="10484729at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="981" mass="113973" checksum="943EF056FA2639CE" modified="2013-03-06" version="1">MVNENLTNTYDIFIINKRTLKSSSMFYNLHKYVELTTRYLLFFVNDSGEQRNEHMIVDFLEDTGVPNFLNRCRTVDEMFLPLTCAGQHVSTNNFDIASETSDSATVGHRISVFDIFCRSREHERNDYTDATRYNKEVILEIINVPLPKALFKKIINSSEKKVPEFTLEEICLIITHFFPLEDKVSIIAYAICVFLQKNSDLVYELKRCDNDTSKEKYSDDIKLLTTVVFDVSGSANSFREIANSYIAFCIKDSTGEIAETVEKNNLSEHICYFINLNELILGFLIKNLTITYNYLMNNGYILLDKLGFWPKKFSFNVRVINITMSSKKTPEDNERFTQKLILLSRCEFLNSERVKDLTLEFKEITFPVSSSLLFAMKNLSTVQYDLCTADFINSMPINIDNRQVRLENQSLEAIGLFSKCKVNLQYADFVFESDFSFPHHVKMVKIKNSTIKKSMKFLFNEECDRIFIENTSGLINLPRMECFNMIVLKKHKRMFFEFDIRDDLQPKILTIRHANIEGMVCLYQGIDQITLEYVQISPNSQLILHEDSEHIDITKSEGLMDLTPYIGTELYIYDNMKIRVQQIPYILLNHIFLCNIRTHTCIELGQRNKCATLCKITTCNSARVVINDNCTDLEIYECNCTIDVTKVVLFDRIKIWFAADGLDNINFIGDVYVTSLEICNVRRCYNFVISLLPIFKELSILKFESNYTNESLDGTEQVIYDEMRSYLQVKGYNRSSTISMKRFPSKTKRIHRSVYRDVNFAVNQIVNAILNSQITYSIEKLEFKSIVITKCCYRRFSEFCNLKILKVMVPKVSSSFLSSLPPNLRLLDISNSFNHDPKWRPDYKNFHLSDHLTLGMLKILVVDTVSLPFIYNISSLMPSLRILKVHFNVRMTWSRSVVLDTKKVQVCKLIVETKKKITISSKITKDNHAFEVYLKPLSKYIDLKSLSSLVFISAEEYIRICPFSSNVLQIVPRQHDIDLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSR7</accession>
    <name>L7JSR7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSR7"/>
    <dbReference type="FunCoup" id="L7JSR7">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2548"/>
    <dbReference type="HOGENOM" id="CLU_1256826_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSR7"/>
    <dbReference type="OMA" id="NIIFMEM"/>
    <dbReference type="OrthoDB" id="2190092at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="220" mass="25768" checksum="AE35681AA6CBF285" modified="2013-03-06" version="1">MQLFYEILNPTALKSFILFLHGLNTKTKDIIANFEMMAKELPDTQIILLQAPKQDVVIYKPVQVTAWYRFKVDETVVYEERESMDESRRKILELIDELKIPKERLIISGFSQGGAMALYTALTHSEKFMAVIGMCTYLSSHLFYQEVYDQKVIMISAKNDEVFSLEFIRFLVSFYNRFFGNIIFMEMDGDHTMNTLILRDIYKHCLEENKNSIRLNNVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JST8</accession>
    <name>L7JST8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JST8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2728"/>
    <dbReference type="HOGENOM" id="CLU_2795744_0_0_1"/>
    <dbReference type="InParanoid" id="L7JST8"/>
    <dbReference type="OrthoDB" id="10476910at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978809" evidence="1">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="68" mass="7136" checksum="6DA60FF8EA448C5A" modified="2013-03-06" version="1">MNLLRFFILGTPVILCVGENAKINKLLYGAGTHGNPLDPQTPAEAAAVAATRSPFYPMGGRFGYGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSV2</accession>
    <name>L7JSV2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2604"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSV2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="940" mass="109852" checksum="9395323664C759A2" modified="2013-03-06" version="1">MWSNLYNYIDVCVKYIFLFENENNSVSEDFLIAGHPADLQMPGLWETQKYIEEIQSLPYIAENYLYVSRKLLGILVAFDRTHYYGHIAGIKKLIYQTHRDVIEKNTNIQFKVIKVPMSFALYHKIVNLSSAHKYFNNDEICTILQHYTQFDKPIMIQLVKVICEYLLNNKEILYEIQKYGEHPSSYQCTSQIMGHLISIFGTKETLTQFKRLVSSHITLFLTDEKYSTVKLCGQSLSDENYRFEIDQDGFALVFLFDEVRIECEWLMNNEDVLDTLFGNNMISSPYMVILYGDGKIFNDLKVIDIFKGISSIISTSKFLKGENVSQLILKFEISYDDVDISCITDIDALTIAQYIYFLPDFTKSLPEYVKMEADIDMHLFITKLDHIPKNLTRILCERIECDNDIIIPDHIEKLDIKKCVLAQNKTLTVGKNCKSIGIADMQGKFVIPEFIECEIGLYGMSGTLCFNFGMNGRNDERSLVLCRVTVYMTVNIKENMERIYFDDVIVTSESIVVFNDKCKNLHITNSKGRFDLRPYIGIVQIFNHKMKIEVVTRKQSTFNLARITFNNWCFTQTAKLSNIYDYVRLIHVSMAENTEIILNKACKVLLVHNCEVTINFQEVEYLESLDIWLSMDKKNNIRLVGLKQVNHLCFFGMCCDTNLIIAILASIENMQHVKFDHSCIVMNTQFFNRCYDGLMTFLTSNGRFENNPDLLSKFPAIQDEVPKVFVLEMLGIMVNYILRNVLDQEIMDTVSMLEFEHIAIDSDNCRLLRKLKRLKILRIRTKTITNEFLYNLPPNIELLDITGLFFDEINRTEKYVIKPSVIIQPYKRLKMLIIDVDFLYNIRSLSVLMPFLEVIEIQYSPLIKTNSLMQWKKIKVNELFIHSDNFGRDYRREFKLKDDEMLWFVEQLKFYIEFESLQCVASVLLDECTFLDPITLEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSX9</accession>
    <name>L7JSX9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2643"/>
    <dbReference type="HOGENOM" id="CLU_847824_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSX9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="328" mass="37846" checksum="37510EDFF200F6C6" modified="2013-03-06" version="1">MPYQDSTKMIINKFLYQMVTIKEMIEKDPMQFDLLNSFVLEVIMVMNVFSGGVMTSSILMKGRLRRLGERGQLEFTHAIIPSEHLPTDLAQKEISSDQNRGKTTEQSTLTHTVIRSGLHATNTTNTEMIQVCLQPGYRYVNDGNKYSLDPDYRKYIGLLERLPEKLKKVLDKEEELIRKIYDIYGECMFGDKDASGHEIPKGMDEWRDEFLDRYQNIFGNISDIMTTDNNNTVMFKLMNINNKIGMLSTQHDHLCKITKIKCGEKHGLSSEYYNNAVEYLTDLQSLINNIMKNEEKSYFYTAKGYVSKIFNRGFEEKAPSNTRPGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSZ9</accession>
    <name>L7JSZ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate transport-inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3247"/>
    <dbReference type="HOGENOM" id="CLU_1262369_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSZ9"/>
    <dbReference type="OMA" id="MINHESY"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="217" mass="25442" checksum="1AB663FDE2418140" modified="2013-03-06" version="1">MINHESYFGCMHKLSHYLSLFQLAVNHEVPTLKRRLSDTEKNAVRAGSTYIYSENESGIRRWTDHLSWTPSRASNECVFYQEIANHNQPMLKKVVTATIDKCKWHIVNYSTVSDEITGTCCAKYQAVYDVPITHNIVVKTKVRCSRNTLRKSLSRNYVRNNAKKIYSFVDESNLYGRRMDVKLLANQNHLYRRKSEESVNDENEECDTFDYKRSCYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT04</accession>
    <name>L7JT04_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2522"/>
    <dbReference type="HOGENOM" id="CLU_2211952_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT04"/>
    <dbReference type="OMA" id="WEINDQI"/>
    <dbReference type="OrthoDB" id="10379299at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="111" mass="12992" checksum="12176731851B8FA4" modified="2013-03-06" version="1">MYVRRPGLCSIRIRNKENIAEEIHEKTGIPPEKQFIHVTKRGPVLLLATNKKIGVEKKDDSENDERKAEILKMTKIFEDYMDDDDDDDITDLEITLKKEHVKDITRNILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT07</accession>
    <name>L7JT07_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3199"/>
    <dbReference type="HOGENOM" id="CLU_829456_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT07"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979110" evidence="2">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="37738" checksum="5CF91E8140BEE990" modified="2013-03-06" version="1">MHVIFIVMFISLSSEMIKGDGLGEKSRGEGRDVATLAHAAEIAVPFLENLKARVIHGLEFLLSILTNFQWEKVGLSLFPHKVVTRPAANPSPAEESDLKRGIKRQLTLMEFVTAFGPTISSFDSECFIELKKSGEVFKFKNSSQYKLDFGKFTRHLKSVSSALCMVRYILNYMYGVPNTELEREVVSFELGPEDPFSGISDNLMEMLDMLGLDKSPFLKQINKLIEPMEGCTKSMLSFFMVNNRIEHFIKFCDEVAKARKELEAYEKDFWLYANYEKAINASFNSCRAGNIPCESLFVPDLMTGKIKRRDATGSMEDGTCKSSSKEDGTPSPTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT39</accession>
    <name>L7JT39_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 13">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_2427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 13"/>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT39"/>
    <dbReference type="FunCoup" id="L7JT39">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT39"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2427"/>
    <dbReference type="HOGENOM" id="CLU_089996_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT39"/>
    <dbReference type="OMA" id="GSMEPFM"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ74643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="176" mass="20523" checksum="3DD939C263024A22" modified="2013-03-06" version="1">MFDLFFSPKEIRNLKRMSKRQLLLQFVNASYSVMGTYMLWKLIGLFLNNDSPIVVVLSESMEPGFKRGDILFLSPRSYDVGDMTVFQINKKEIPIVHRAIRKLGTKVLTKGDNNLRDDVPLYRPGQYMLEPNDILSCVFGYIPYFGMITIWINTFPWIKVLILFCIGMTVFFTRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT94</accession>
    <name>L7JT94_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2391"/>
    <dbReference type="HOGENOM" id="CLU_2924360_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT94"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="6822" checksum="7DE99EF1269D3857" modified="2013-03-06" version="1">MTLSHKIPMKNLLLLTEHVANVDFGVKDIKKVLVDTKIQGNTLKTTEQLIEKVLMIVMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT98</accession>
    <name>L7JT98_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2397"/>
    <dbReference type="HOGENOM" id="CLU_285933_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT98"/>
    <dbReference type="OMA" id="CLEYRLY"/>
    <dbReference type="OrthoDB" id="10491340at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1082" mass="121981" checksum="007E886E77E1A856" modified="2013-03-06" version="1">MQKRRAKEEKKLNGKLTETIDKNAKVTDVKPNEIIDFSAWLREKKVEPWNLYAMRVARARSILGSFLEYKRFITLEHQKLFGDDTLIFQDVKRKKVWDMNRNVKSIYIDHRHRDDEDTIIHDEVECIKCLEYRLYREIGEEVKDKIRLAFQQIQHYLYCDRSVLYRRLNKPRLDLIMDVRNILIGQIEEFGCAYHGKPENNLANKICQFDDSVEYKENDPPRYRGDKPVITFEEPKGSRYEQSVRIREKGRYCKRLRERLFVNDYKKITGFDYVPRDYPRSKEKYMPVAKCIESCPFIGPLHYMLRRYGWPDENLHFNTLDGYCLENGTRVLDCGCEVVDEGGVDPKYLYSNKSRDEYRKLYEEKEALRRELEELKGKRARFAEPLVTDVKPVLNEEARERFAESLTDVKSVLNEEARERFAESLTDVKSVLNEGAQEKTAQVGRAKDTADSEPYQYLIPTRKEPPTALQMKLGNAILVKRSKEETQKEREFLKKLETMDVYRGNPADYYSTEYNRNELVPPIFHTKCKITEDRGQNGTIQENEERIEDAGKGSKQEESAGRVVPVNEEAIHVDQGPTSFSGRVDSNAAIVSPGMINEEDRIAGVNSQNNLEFGRNANGTGPALVRDGNAGKAEDVHTPVTPKEETPPFLNGNKLGTLPENGISTQEIRKTPESDVHPSNSYQNICNMPALGSKTAQRTVADHDEDHRLLKDTNQPADTGDAKRRLRGYGVNTAGTANLRDVGPLYGTGMSTDRFVSAGVAQPCSAQPLDQINMPESAKADNSFVSNGLHPGEHAASSNVQGNEHALFKNGPLVNDQKVSAIFQPFGLTGNNAQNTTQGLNAPQAQFSNEMHDLRQNAAQQENNDRAHGWNNGLERTNLFGSSTGVQPWDQRSKPEHNLFNTPSGANVPWNHLSKQQAVPSDLKGTQPLITAPFNTPINLFNDSDTHEPNEFTGPTGNNGRMFGSMNESSAGQEVKNGGHQLFQQGVQPVRPLSFYNPGQHTNVQPAFTPSGTAFNYGAPPDFSNGGQFDRNTAPSSVFSLGSGTGNAEDVNEGNKEEPGDGLKRLDHVLKGGFSWSSFEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTF9</accession>
    <name>L7JTF9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTF9"/>
    <dbReference type="FunCoup" id="L7JTF9">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2774"/>
    <dbReference type="HOGENOM" id="CLU_012712_1_0_1"/>
    <dbReference type="InParanoid" id="L7JTF9"/>
    <dbReference type="OMA" id="PMIWTKT"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="325" mass="38399" checksum="803D2C06D0A8ED8C" modified="2013-03-06" version="1">MNMDKDRNKILELLQTIKEGRWKLTQFKSGKTNTTLFCTNDDYKVVAKIYGKNTSDFINREVEKSNISYLHTYGLAPRMMASYENGFIIDYVPGKELQEQELQTHYEVIARKMRKWHTIKSPGVPTLFKTMLDWYWKAHVHHKSLLDKYNVYDFIIETERRVKHCEVGFCHNDLLASNIIMLNSPVCEQDLVISSVTQESAQPAYEVDEVQFIDFEYSSPNYIAYDVANHFAEYVGYSLDKSRMPSESFKKEFIRTYMYSGFTVNDKIIDDFLADVNLFIPVSHCYWGLWALLKGQTREKHFDYFKYAEFKLEMINYKVKNNSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTL5</accession>
    <name>L7JTL5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2436"/>
    <dbReference type="HOGENOM" id="CLU_994621_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTL5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978843" evidence="2">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="280" mass="32078" checksum="67857990C3E0DEB1" modified="2013-03-06" version="1">MMPKSTLILLVCYCLLELRGMGQQGNKTNSIDSSDAYSVLTNSERADSPLSVRRKNDNGGPMSLIWRAIEYALSPDSKLGTVAEFVWMKGSGLIELAVRICEPILGPGETVFENIRWLLVEVFTSIMGKPCDTVESLSNPGRDFIKELNRILQSKDIKETAEFTTDMNEVKAKQEKMGRFITDSEMLGSWAGLCMNSWADRERWNILDSRCVIWVCRHLRKFKEGVLEPIVYYLRTWNVALAFYSVLFLCHLWKMYNKTVRRLEKVVVVNKLVDDDNNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTS4</accession>
    <name>L7JTS4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994021">
        <property type="protein sequence ID" value="ELQ74819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTS4"/>
    <dbReference type="FunCoup" id="L7JTS4">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2251"/>
    <dbReference type="HOGENOM" id="CLU_129470_3_0_1"/>
    <dbReference type="InParanoid" id="L7JTS4"/>
    <dbReference type="OMA" id="KKKWTTG"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="150" mass="16987" checksum="D264B5D572DA33AD" modified="2013-03-06" version="1">MKGRRTSLSAYAHVFTHKIFSPSMAKKAPESKASKEAKIAKSSSKEKKKWTTGKTKDEVSRQACVDPELLGKIVKDVPNMKMITRSTLVEKYNINLYSSIRVLRWLCENEIVGCVSAGRRLKVYCGSKFVKKEVVEDVTKKEEELEAWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTT3</accession>
    <name>L7JTT3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994039">
        <property type="protein sequence ID" value="ELQ74466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTT3"/>
    <dbReference type="FunCoup" id="L7JTT3">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2613"/>
    <dbReference type="HOGENOM" id="CLU_011220_4_0_1"/>
    <dbReference type="InParanoid" id="L7JTT3"/>
    <dbReference type="OMA" id="RVEWYIV"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="169"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="390" mass="45417" checksum="9E558D2DBE075135" modified="2013-03-06" version="1" fragment="single">VPVSKYHVHDLSRQFLLILIPFIFNRVIYSFSLKLFFPIFSPFNPLNPIIFITPCQKAMNNRSARDNSIQSIRINSDATTFTDKKQARIELRALRDAFYLKTVKPNENTESIPQNTVLKRVTAYCTAEKINLKHLSSFLRNNPMFQQSVIYFGECLYTSVAIERGSVDVFFFDYGVTVFWGVSENVETKILKIIKISEYNSYDTSKIEVENFQYGIIDTQSMFCNDVIYLNTEDYFHKMIISNAIAQSVKLDYFENLTDKTIESVKDLPEEVENWGRVGRNRKEILKMVGRLHKLRIDLNLVTNILDEPEVLWHFPRYSELYESLRRCLEIKARADILNLRCDVIHGVLEILSENINTRNSENLEKMMVGLIFVSIVVGIFQILVLLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTU4</accession>
    <name>L7JTU4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 2, alpha subunit (EIF-2alpha)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTU4"/>
    <dbReference type="FunCoup" id="L7JTU4">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2204"/>
    <dbReference type="HOGENOM" id="CLU_033458_0_1_1"/>
    <dbReference type="InParanoid" id="L7JTU4"/>
    <dbReference type="OMA" id="WDWLHEL"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="294" mass="33301" checksum="E9831A78B6C6B7BA" modified="2013-03-06" version="1" fragment="single">VGELSKKRIKNVQKMIKLGKIEVCSVLRVDHEKGYIDLSRKKVLASDFDECYKRYCQNKIGHNIMVSAAKKMNVNVIELYDSFGWRKAREYGTLYNYFGQLMNALSRKTDGTRGTVNGTVPEDVHAPDASIAADNTDEKLAKHETKKSNAVKAMATYDELVKDIDPSFINILVEQTKLKYNIQKVKIRADIDLTCPAKGGIEAIKDALRSVKSVDDKIEVSLIRPPTYAITLLLHDREEGIRLVKKGCEQVKKRIEELNGTYAEVNEVKVYGVKEKKDLNRRFGEAIDVESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTX4</accession>
    <name>L7JTX4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2127"/>
    <dbReference type="HOGENOM" id="CLU_887281_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTX4"/>
    <dbReference type="OrthoDB" id="10621575at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="314" mass="36579" checksum="5ABB9B9CAA0280AD" modified="2013-03-06" version="1" fragment="single">VKEITNKNGCAGLMQHLKTMYEPLKSIFTISVIGSIMFVIDNKDFKLLFVHQYHKQQKSDDSHLFKIDINIDPLALGSCVELFGSLKFYHMKAIIKTHTGIQEYLPKILNYFNYIIKLDLQVDHITDETMQKLSTLKLQEFHVDVARLKFEHLRNFLNFRSLVMEIIAENLQIDSSSQITPIVLNKACHKCVIKIQDYSLNKFQDASIASKPSNQQILTELVLNDLDSLSYERRLVLELNSTLFHPIYGQESTIKQLTLTFEDESRVNDLLQRCICLKFLNLKLKKIMKDFSFIDSMSLHPTLQYLKSYCDRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU29</accession>
    <name>L7JU29_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Aspartate--ammonia ligase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994007">
        <property type="protein sequence ID" value="ELQ74929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2137"/>
    <dbReference type="HOGENOM" id="CLU_864831_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU29"/>
    <dbReference type="OMA" id="QSRICMF"/>
    <dbReference type="OrthoDB" id="2191791at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="ASPARTATE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073:SF5">
        <property type="entry name" value="ASPARTATE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="322" mass="37737" checksum="8AC0B4675A3B22E9" modified="2013-03-06" version="1" fragment="single">VNWYPRMDFRETQKAIKIAKGLFEQKLSGVLHLEKIVSPIYIKDESYHDTLDGAQRPIKFDFKNGEHGMILHSLAKWKRAILSKYGYKDGEGIITDMLAIRRDEDISRLHSYLVDQWDWEMTIIKQKRTLDFLYEIVEKIFSVLKEVENEINMQYPTLSKKLPNNITFITTQELENMYPEMTMDEREYEIVKKHKAVFISQIGGKLMSGKIHSVRAPDYDDWMLNGDIVVYNEKMDCAEELSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRWVYEWMQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU59</accession>
    <name>L7JU59_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2494</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_937457_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU59"/>
    <dbReference type="OMA" id="MFYSEML"/>
    <dbReference type="OrthoDB" id="10327929at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="297" mass="34336" checksum="02A45924223C411A" modified="2013-03-06" version="1">MNITSFNSPIALRHMLVIYSVPIFSATLDISSHPVEPLYFLCSLLFVLFSTLPIAQKNKLLILTGMHAISLLVKSRMMAYMVYGGVMTVCYNTSLQTCLSIGQMENVCMMFYSEMLGHLFAVFVPFHSVLALLIIAQFFLLLKAKKLPLEISTTEKQKFLPSLYKKISGLYDNNYTLLSNEYKMIIEIIYKKKKCRQLFLFIWLCHMPMCYSAFGKIVVSVGPLIPVYKKNLVIFLYIFLWVIGIELGNITSWFVEWINDGEGPYNSMSFCISVRLILFFVVYSFYFPMWIERIVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU70</accession>
    <name>L7JU70_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_515045_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU70"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="529" mass="61190" checksum="7D76C54DC48099D9" modified="2013-03-06" version="1">MAGDSKKEAKEGKKNDEAVPDKKAEGENEQVKNAEDDNEENKENXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAESGVTVELDNQEVVENARKEIIQEFIAPVEKEESNVESEINQQLPDQPIRKFKKKRMMRKKTFSIANLDEYLHYKYRKVDRNLRMLVEVLIVCFLFMLFPSILYIWYRPSDYSIFKTLNHEGKTNAILEFCRQNIFLSLTYVIFTASTVLMDYSLQMIASVLSSFDVKVEGYVADFLEVLKLYSHYLRNFFAFSLVFLLSNVLIMRYRFGKKSFTTTYLCVTFIFWFSCLSAVLFFEKLLVNILTSEMKKSSFRNRIWDANYKTYVFKKLAAIAEAVPRGQYEVQLAMRSVQNDYDTGYFLRHNDLDITTEEKAENIAESIFAYLDVDTLEYEQMSTYFQNRPEEVMQYLGNTNKPAEEFRSILRSSNSVRLSCAASATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUE0</accession>
    <name>L7JUE0_TRAHO</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2171"/>
    <dbReference type="HOGENOM" id="CLU_1373067_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUE0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="199" mass="22379" checksum="E30C11C77AEA1157" modified="2013-03-06" version="1">MVEGLFKYLEKSKEKKNEKEDERARSNTPVKKAEVNNSLFDDSIVSTSDNTRTGKKSTTPQNNYNDIQSNAPTSAINDDTRGNAPTVTVPNAYAYNQGNVPALPLSTTNNVQSTPPNNNPFNNPQNMFNNNFPNTLLTNIYSQLQRLTDSISQSRVPPRTPLFKMPVVKRKKLSAFTEPYRMNDYEAVVEEKRKKTAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUE2</accession>
    <name>L7JUE2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993989">
        <property type="protein sequence ID" value="ELQ75098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUE2"/>
    <dbReference type="FunCoup" id="L7JUE2">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1963"/>
    <dbReference type="HOGENOM" id="CLU_053173_1_0_1"/>
    <dbReference type="InParanoid" id="L7JUE2"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="351" mass="39601" checksum="B257D3062918AF98" modified="2013-03-06" version="1">MKYFNPSDIRIHMLDVQLVIFYAVLTHLLHGSSIKQSRSVIRQRSCSKIIAMLITYRAFSFILSNTSTRSYSRARSKKFIKKFFTHPTAIMSKVSPKERKQLLFSRTKDYFTQYSQFIIVGLNNVTSSQLQSAKQAWHGKAEFLFGKNTTVKKALRDMGHDDIVSRIFGNVAFIFTNGDVREIKHIVEDNKRNTFAKVGAIAQTDVWIEKKVTNMGPDKTSFFQALGISTKITKGKVEIIQNSKALTAGEKVTPSQANLLAIMDIQPFVYAMKMESIYGDKQFYEPWIADITDKDVEDSLVKMAQRATACALGMGSITKTTVPFDTKNALRKVVALSLAIGYDVDLAKPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUE4</accession>
    <name>L7JUE4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2119"/>
    <dbReference type="HOGENOM" id="CLU_2832980_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUE4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7707" checksum="1838D578D501805F" modified="2013-03-06" version="1">MKEYYKESVKDLYSYVGNQQTVGSLPDMNDILRRVEELDNDAEKMMLELSSIYKMIHEGLMKLNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUJ8</accession>
    <name>L7JUJ8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_1964</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="JH993989">
        <property type="protein sequence ID" value="ELQ75099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUJ8"/>
    <dbReference type="FunCoup" id="L7JUJ8">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1964"/>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_1"/>
    <dbReference type="InParanoid" id="L7JUJ8"/>
    <dbReference type="OMA" id="YGYTCNM"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ75099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="334" mass="36775" checksum="88052D9129EFA03E" modified="2013-03-06" version="1">MLPLMIVGINGFGRIGKIVYRVMRQRGHKIPLINDPAIDACTAAYALTYDSVTPQKERAVKTGENEFKYLGETTKVTTHCEPKLIPWRDHGVEVVIEASGFFLEHEKCMAHIKAGAKKVVITAPSPDAKMFVMGVNENDYNGEEVVSNASCTTNCLAPIAKAIHDEFVIVEGLMSTIHAATATQKVVDTVSKKNRRLSRSFSNIIPSSTGAAKAVGKVIPDLNGKLTGMAFRVPVMNVSVVDLTVRTQKECTLEQINECIRKAAEGRMKGIVAYTDEEIVSSDINGSEYSSVYDSKAGIQLNKTFFKVVSWYDNEHGYSCRVVDLAEYVWNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUM2</accession>
    <name>L7JUM2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994039">
        <property type="protein sequence ID" value="ELQ74467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2614"/>
    <dbReference type="HOGENOM" id="CLU_928082_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUM2"/>
    <dbReference type="OMA" id="DVNLCAM"/>
    <dbReference type="OrthoDB" id="2192470at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="300" mass="35749" checksum="6DD232EB03692B7E" modified="2013-03-06" version="1">MADLKHLIENKEYQQILELEGVQYDRFKVTCLIHLERYRDALILMKKMDAEHTKQQNEVGDKMQKMQIKEKMSGDMRYEKAYALYKLKKYKKSLSILKRMEASERVNVLLSQVYYFLRSYRKAYNTLSKCKYEKERDVNLCAMDSLSRISLRRREDDEQIHHIELKPGHLAGQMAYNSSFRDFHFYDPEGYVHKYKNVSNGYIQEQIANLIGCVDLDKLSKKKRKIAQYNLNNDPNFKKYLLHRNRDSFKKLLLCSGKSSLKNARVEDEHLMRLIEYIQMNVDEKVSADILKSAKKSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUM3</accession>
    <name>L7JUM3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">THOM_2063</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPII-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 13">Endoplasmic reticulum membrane</location>
            <topology evidence="3 13">Peripheral membrane protein</topology>
            <orientation evidence="3 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Golgi apparatus membrane</location>
            <topology evidence="2 13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUM3"/>
    <dbReference type="FunCoup" id="L7JUM3">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2063"/>
    <dbReference type="HOGENOM" id="CLU_008658_3_0_1"/>
    <dbReference type="InParanoid" id="L7JUM3"/>
    <dbReference type="OMA" id="LFHGERE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="15">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="16">
        <location>
            <begin position="118"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="18">
        <location>
            <begin position="376"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="17">
        <location>
            <begin position="473"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="14">
        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ELQ75020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="703" mass="80808" checksum="408A51128D4CBD3A" modified="2013-03-06" version="1">MEEAIHEIEKNDGLRMTWNVLPIVDTEESSLPIPIGVLYSPHQRCERLEYEPIFCLTCRSILNPYTTVDYNTKEWTCIFCNKKNHLPPHYRDISPESLPSEMISCTTEYLLTRESTFQPTFFFVVDMCTFDEQRYNLLIDGIRITYDGLPDECTIGLITYGTNINLFDFQSEIKRTFIFSGERNYDKKTLEGYFKDENANSQFLSFVFTKKTVDVNDFVKMMERDPFPVRSGLRQIRCTGSALSFAVSLLESVVHDAAIKIFLFTEGPITFGPGTMASLNLKENIRSGNDILRGKAKYVKTSKSYFDALAKRMANLGMSIDILSATLNDIGLYEMQSLIDMTGGLVVMAQDFDHEIFTTSCAKNVRSEDGVMEMVFNAKFKVQTKGLTYKSGIGLGSPLLNQKNEEIGWKLGSLHRNSNIGFIFDAKANKRDDEIGYVQIITQYQQSDRKLITRVTTAARVFGRLSKFKQGFDQEAALILQARIFTFGTHIEEDLDLVRRIDRSLIRFIRKFGESNNHLKLSSSMALYPNFIYFLRRSLLVQTETNSPDETSYYRNIVAREPVTNAMTMIYPTLTAFSYQDETKPVPMDAKSLQPDIILLLDTFHNVLIWRGEHINQWIQEGYHEKDEYKFLKDCIDEAEERAKRLVKERLPTPQFTLTERYGSQERILLAKVNPSIKGQVVVTDDIDFATFYDCLCKIVKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUN5</accession>
    <name>L7JUN5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Origin recognition complex, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUN5"/>
    <dbReference type="STRING" id="72359.L7JUN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2010"/>
    <dbReference type="HOGENOM" id="CLU_1138763_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUN5"/>
    <dbReference type="OMA" id="DFNFIMK"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="211" mass="24688" checksum="8491A87A2F62B657" modified="2013-03-06" version="1">MKKKLKDFHISCVPEYLTFLKTFNILFYGYGDKSVLLREMFPNANFINAYPATLSKSKINIIFKFDLTSTDPEKFPKNNVVCVLDTMDPTAINFCDEDLEDFNFIMKDLTTYVPYENVFEVDKGEADLKNLLNNVPKRSRNLLKIFINLCENNFALITELLNVAKKELFITNTKTIYQLLGEFVDHRIIKYREDKIVLLVKKEKILCHMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUT1</accession>
    <name>L7JUT1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2273"/>
    <dbReference type="HOGENOM" id="CLU_710156_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUT1"/>
    <dbReference type="OMA" id="HKLENDC"/>
    <dbReference type="OrthoDB" id="10377156at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="389" mass="45599" checksum="C22A9E8C95496393" modified="2013-03-06" version="1">MLVCEHCGTSFISCDGILVCKNGHVLEQNLEVVEDEFAGRKASSSLKPSVKKKSCSNFTHLRILFKVYKDFKKKYDLNDDIMKIFLQNIRFTGVLIKKSKSLVSINLLVLVLYLSLRIKKSIQKPYFIRDFVDDISDLRTLTSKHKLENDCRERNALLFINKVNMVYLMNQLDNLDLEFNMNSYMLSSLDCGFIVFVRYFLRVVKDISGVYDFRNDENFQSSELDFRKFNIDKKTMIESLLRIRSCSLINEPEAKDKDNRDEVNTFPFLQATDFKVQVDNAKDGDICIFFINGILRNLYILNTSQIARETLTSYFLKFLFISDFSDRLFFYELEVCSFLYAYAKSKNKSDALLLEMLNFILKYLDCSEPFFARYVRKIFKIFKSSQAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUT9</accession>
    <name>L7JUT9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Divalent cation tolerance-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2283"/>
    <dbReference type="HOGENOM" id="CLU_098807_2_0_1"/>
    <dbReference type="InParanoid" id="L7JUT9"/>
    <dbReference type="OMA" id="VYTTFPD"/>
    <dbReference type="OrthoDB" id="2017693at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="DIVALENT CATION TOLERANCE CUTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419:SF8">
        <property type="entry name" value="FI09726P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="105" mass="12500" checksum="68C12EBF26D13168" modified="2013-03-06" version="1">MEFPVIIFTTFKDENEANLILESLLRKKLIACAQKIQKVESMYVWNGKIETTEEIQVKMTTLNSCVLSIDNVISKMHSYQVYQFIAVRLEYVNEKYIQWMWQVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV79</accession>
    <name>L7JV79_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2118"/>
    <dbReference type="HOGENOM" id="CLU_3015874_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV79"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6707" checksum="1F053D71D358DCA6" modified="2013-03-06" version="1">MCHRSCTLRMTKKNNLEEIELKDLDYLKISDIKNDNSEISKELRAFYGKLFGYKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVG5</accession>
    <name>L7JVG5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993954">
        <property type="protein sequence ID" value="ELQ75478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1582"/>
    <dbReference type="HOGENOM" id="CLU_1656412_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVG5"/>
    <dbReference type="OMA" id="TKMPRIV"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="160" mass="18542" checksum="40A108B4F2D71720" modified="2013-03-06" version="1" fragment="single">VSIDFQRNFYVPEETETLTLENIKMQEGQVLKINTNCKSLKIVSFVGVLDITDVKSLRSVVLHTKMPRIVDGQWIYLNNDMIDTSSMSDVTDYIFPYCLEVIVLRNVEFKYSSPLIISQKCIDLSIISCTGNYDLSRIKKLRKLTFYPSQHKKILLHFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVG9</accession>
    <name>L7JVG9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">H+-or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily</fullName>
            <ecNumber evidence="12">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1792</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="12"/>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVG9"/>
    <dbReference type="FunCoup" id="L7JVG9">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1792"/>
    <dbReference type="HOGENOM" id="CLU_107724_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVG9"/>
    <dbReference type="OMA" id="MVNVACG"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="16382" checksum="56BD4A77FF6D3607" modified="2013-03-06" version="1" fragment="single">VNDAFFAYLGSFLCFMLNAIGTTKGMLAISRTCAGSSIFNPKIGSKSLVGVIICEGNLLCGIVISYFIFNSIPYESKNLKDASYILFSAGTITGAVGFASSFATGIICAAICVMDAKEPKLFSKLVFYEFIAGSLGVMGIGIGFLIKERIKMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVM6</accession>
    <name>L7JVM6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4 10"/>
    <dbReference type="EMBL" id="JH993989">
        <property type="protein sequence ID" value="ELQ75096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVM6"/>
    <dbReference type="STRING" id="72359.L7JVM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1961"/>
    <dbReference type="HOGENOM" id="CLU_2032259_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVM6"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="122" mass="13337" checksum="9821D74C1C619689" modified="2013-03-06" version="1" fragment="single">VVKNGDQYKVVNRIDDGWMGVDIGPESLKELERLVNNSQSIFWNGPVGMFEDEKCANGTEKLVRLLEMAQKKGKYVLVGGGETAYAARMFGHLENVSTGGGALLSYMEGADMPGVNILEREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVQ1</accession>
    <name>L7JVQ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1950"/>
    <dbReference type="HOGENOM" id="CLU_1200534_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVQ1"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17003">
        <property type="entry name" value="Actin_micro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="231" mass="26921" checksum="F48805F7A1CAC20D" modified="2013-03-06" version="1">MSNITLFRAEEEFVDEFDSWEEFKLDKTFRCDVCGTWFVREGVFMHVVKKHIKNGKCECRKSKNSKSEEVTGVKERCTDEHEHSSNNAHELSAGDAAEHPFNRSEGSVSFLNVETIKNANINDSIKQHVKGHITYIFKGRSVYDKIGHFIKVYLTKERLKKINTIVTDEGTISKMKEHFNNFTYVDIGKASAWRGAKDLMRIDVAKELWMTDKEWNATRLRVLKEKLLFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVR6</accession>
    <name>L7JVR6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993942">
        <property type="protein sequence ID" value="ELQ75573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1477"/>
    <dbReference type="HOGENOM" id="CLU_2529069_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVR6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="84" mass="9146" checksum="02316444FCBA5576" modified="2013-03-06" version="1">MDMVGAMVVDGVVLIDGVVLLMDMVGTGVMGVDGVVLLMGMVEVVVVMVVILQVVGVVVMDMDMLLRVPWQEKLLWVILLHRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVY7</accession>
    <name>L7JVY7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993953">
        <property type="protein sequence ID" value="ELQ75480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1572"/>
    <dbReference type="HOGENOM" id="CLU_1295214_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVY7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="233" mass="27606" checksum="70AC748CF164E598" modified="2013-03-06" version="1">MYTEPRKADDNNCGIKEKVKLLNGIVNVLIQPIFNVRAQNTLETLGLLEFRLDESNINILGGFVVLTKICVSYEMIDTIFLSSIPRNVRQLEVLRNLNTSEYFNECCILSNYQCIKLLSELKCIEELTVEGHFLRRAQNFQSFPPNLKHLKVSYFDYYESCYESNNIRFVLNKLTLLMYHNEESRVKWDDVERRIRIDEMLTHLSRYIELDKLEELIVEDGENEPYHYFPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW04</accession>
    <name>L7JW04_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW04"/>
    <dbReference type="STRING" id="72359.L7JW04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1824"/>
    <dbReference type="HOGENOM" id="CLU_1497256_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW04"/>
    <dbReference type="OrthoDB" id="2191694at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="180" mass="21729" checksum="419FBCB2A81248CD" modified="2013-03-06" version="1">MDSIFRTCEIVKYDNKIKTSDFLSSISDKNSSQLRDFCFKIMEIEDPFHSLSLLLRIRTSEQFIDSLFMERLSSLIRKINGEKYLRIKNMDEKIYWFVMRHTKDSDVQAMIRCFSFIEINKTNLEELKRYFSYSTIYQHYRSICKNIFKGKYRRQEISLVIRLLDSASLCFKNLYPIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW06</accession>
    <name>L7JW06_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1829</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW06"/>
    <dbReference type="STRING" id="72359.L7JW06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1829"/>
    <dbReference type="HOGENOM" id="CLU_1469215_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW06"/>
    <dbReference type="OMA" id="INCGMNI"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="184" mass="22257" checksum="1FD834CD584CC066" modified="2013-03-06" version="1">MHEFLANFQGMSLFKITNFKNLKTAKMFHKEIINNLRTAKKVFIITLYFGNKQKTREIMEEIRIRKQKNLETMVIIDYNRCKQNEQIFVLLKEYQIEDVVCYANRKSYFLLPNCIKELFFVLHVKMYLFDSLVILSGANLEDKYFTNRLDRYFSINDSELAEYLMKNVFNYFYKSSYVESNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW63</accession>
    <name>L7JW63_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1778"/>
    <dbReference type="HOGENOM" id="CLU_1435450_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW63"/>
    <dbReference type="OMA" id="YYEYEMM"/>
    <dbReference type="OrthoDB" id="10374048at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="23611" checksum="ACC8EC2EAF6C9FF6" modified="2013-03-06" version="1">MVFLNVKPMEDLEEKIRRKHQNDYLPQEVVDEYIRAAINHGLIVEEDLKQLPKQITFEGLKAKLDEFRHDNFFHGSFESVDDNVLYSVKENRYNTMDCNDTPHYINQIKNKTNNIMGKEQTMYHSFDNKCNLEKKEQRLKNVLNAYYEYEMMKMNRFRDEQRRKNRTNIIIGSSIAFGLFLTVLVLLLDFLEVNKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW87</accession>
    <name>L7JW87_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1336"/>
    <dbReference type="HOGENOM" id="CLU_1220436_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW87"/>
    <dbReference type="OMA" id="EVKINCV"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979194" description="SUN domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="227" mass="26044" checksum="8923C112BD92338B" modified="2013-03-06" version="1">MVLSGFIFLLFSLAACTRGCNYASSLCGAFIVYTSKNLDRADAILNPNSDHYAIGELMPTYIIVKLCNEVKINCVELLNKEYLSSFPRQIKFSTYIDGNWVSLGSFNCKFTREKQLFYIKNDVFTSILRIDVLNFIGKHSLFTITSLKVYGSTILENLKVNNMVYNRVFDLNNKLIRYEDKNDIDDIMKSIRVAKMLMEKSKIIFAGILGLTSLAVFYFIFKKSLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW91</accession>
    <name>L7JW91_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1453"/>
    <dbReference type="HOGENOM" id="CLU_1202377_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW91"/>
    <dbReference type="OMA" id="YTHYPEL"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="231" mass="26459" checksum="D877E48C3DEFCF13" modified="2013-03-06" version="1" fragment="single">VALKTVGSRKESLVTIHIILVINKKGQQKVPMAKITKTIDLKKLIKKLLILILLMWFIWLVVYFFKNMNRSSLLSPNKTKDNERPMKAGSEVRIAEECGNKEDKTCKRDGTGRSECKNKNDGNGGGIVGGNVTGVKIEKNVTEELNRDKDRDIANEYKEKRTVSTNNNALNEGYQRLKQFLSQGHYRKVYTHYPELNDETGNRWKEGDVSDAIEKLMEKMRNKCLSVEIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWA1</accession>
    <name>L7JWA1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1351"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWA1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="950" mass="110231" checksum="2A4CC0985637F3AB" modified="2013-03-06" version="1">MLYNITDYLRATVIYIVVFPSVSGDDNEYMVFDNLQHTNMSKLFTSLEQGVPYSNYSIEEFDVKQIINKDAKSNSDPNSTDVDSETDEIKPKRARIERPPAYYSCISSYFKPNRLFKIVRVPFSKTLYQKILGIDFKDLKFVKNDYIDVLKYIFWHLDDNTNLLYNMCESIQACPEEFLKIFENDTGDKANPSLLCNCDINSCNCDFERSLESLREVMNFQVKCELTDNAEEIVAVVYGKDRCDKQIIFTESFEYFGFGFFFECLDIEYCYLRNNVDLIYEVFHNRPYNTKLTIMMVDDRPIHELKAALNEKYTPDEDFMEILQHNFSKQEYIENVIIDVQYAIYTGDSPLHNVEYPYDCIKGLKFSVDFKNGELQPKRDTKIRFYGNIDTIQQSPMFTTATHIQLVELEFSQNFIFCNDWKSLKIYDSVVLQGITVTIKSSCEKLRLRNVVGAFNLSNIAGLNEVTMSKYSKFEFINGRKSITSSLHLSCLKIDTPITIAENILNIEIEKIKCHDVITLKVTSEHKIVKVCSSEGKFNFQGIFCGELDFNEKTIFELEKRDESETSLTFNQCIINTGISLLGCFNKIELLGIKIGCDGFFEVNKNCKILNIIYCEGRLIISADVHLKKLKIILSGVSEELIIEGSPNVDELILEDFPCDEGIIMNILGMLKKVKFLKIICLCDNGEPTLEFWQHLNKMYEESPQFVKLLVESGQSENKIILCESEYDKIEVYPTVKNFVDALYKSELMSQVYSITYGKMRISSYELQKYSSIRNLKALKVGIQNFTNDSFQHISREVEFMNLTGSYIPSKQLDSEFRTLKEFNKLKVFVVDSAFFTNAVNFSFVPKSTEVLAIEYSTWGETSRTNSKVEKIKLNKLFLLDETKKDYHEDEIVIDKDVCETLKTLSYYIDMKNLENFVFVCKNEQYEIDPLNFTLLRRYNQKLSLEIDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWC0</accession>
    <name>L7JWC0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1291"/>
    <dbReference type="HOGENOM" id="CLU_2905759_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWC0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7500" checksum="B4C9553656092E34" modified="2013-03-06" version="1">MIANFGRWKMKLKQSKKYYGIRNGKSNKKCRYVRHKFFGGMFRKRADGYQRERINSVSVVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWF0</accession>
    <name>L7JWF0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_1673</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWF0"/>
    <dbReference type="FunCoup" id="L7JWF0">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1673"/>
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        <property type="term" value="C:chromosome, centromeric region"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:histone H3 acetyltransferase activity"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="35"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="280"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="433"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
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            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ELQ75376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="490" mass="57754" checksum="8954D13E3E7B71F2" modified="2013-03-06" version="1">MEDTETQSNTNKKEMREKDLIAMFKAGKIQFKLVSTYKSWDTDTKESLLAFKMILQKQLPRMPKEYIIKQIFNEKHRNILCLIDGTIVGGISYRPFYEQSFVELVFLAIDSNVQVNGHGSMIIDILKEHCKREIQNIETDFLEYLSYPKRLKHPIYLMAYADNYAIGFFKKQGFSTEIYFKNWRGYIKDYEGGTLMQCKVLWEINYLNKIEIVERKRMEFINKISQLSSFNVLRDPPNFDDIKTVWDIPGLREAKLTEEMLSQTTKKLKNVFRYIISDIRTDTHAWPFLQPVNEKEVPDYYQIIKTPMDISKIEQNVEDDKYESLEVFEQDFALIFKNCYIYNAPSTTYCKCAHVLEKRFKERMREVKKTLNGDKSAQNDRHEKEIPPKHSTPQEVLTQNEYVSPPVPLPSNDFGAFKNVVLSSNSLEKHERAYEYSDKDKKNNAKGEIKDAQARPGTTEKKRDEQNDEEEKSGNLFDINFENHHSEDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWH5</accession>
    <name>L7JWH5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Homeodomain-like, Homeodomain-related, SANT domain, DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75650.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46993">
        <property type="entry name" value="MYB TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46993:SF6">
        <property type="entry name" value="MYB TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="283" mass="33013" checksum="16E2229A39939D18" modified="2013-03-06" version="1">MTDKKNITARKRTSTKTHEKEEKENTDKEPITTDTDNENDDETQTSESAEDTYVSEQTDTRGDGHDNDGFSSDREKRVIFTGAVTEEAYDFENMDAPACSFAVQDYIRKYQINPQGITVPPSYAQPVMPAHSYLFSRKERTFWSATEIEYLRKGVQMFGCGRWKKIHKAYEEHFQRGRRPCDLKDKYRLLTKRTSYRTKYAKQFVQLDANHRKVDNVVYERLFPFEAAYDIAQLRGKDEMVIYLANAKSHSDSSGRYYNVHKYLVSIIEGKIKVSRIVEKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWH9</accession>
    <name>L7JWH9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1654"/>
    <dbReference type="HOGENOM" id="CLU_2924358_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWH9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6925" checksum="64D9F27CCF1766D7" modified="2013-03-06" version="1">MVLLFSAPVIMMSVLTKLFPEQESIMGALSVALLFVILGLICLFVHRIECEEEEEKKLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWI7</accession>
    <name>L7JWI7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWI7"/>
    <dbReference type="STRING" id="72359.L7JWI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1946"/>
    <dbReference type="HOGENOM" id="CLU_026126_12_1_1"/>
    <dbReference type="InParanoid" id="L7JWI7"/>
    <dbReference type="OMA" id="KPECKFT"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="222" mass="26350" checksum="28171D34A107FCEB" modified="2013-03-06" version="1" fragment="single">VSFPMDRSPHELSAEEKKNEDELNNIFFKLQNYTNIIAHENDEQEIDALLKYIDDDEYIIVNLSISPVLKERFMKTYSVEKLPILISYSTNIYNDENVDAYLKERKVNEDSFIDHKIDKMVGEKKVMVFIKGSPDKPECKFTKELISHFDELQLKNGKDYSYFNIKLDNKTRNRLKKRNNWPTFPQIYIDKLFVGGLDTFKKMKEKKIVQKMLFPGDQEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWR1</accession>
    <name>L7JWR1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative arsenite-translocating ATPase</fullName>
            <ecNumber evidence="3">3.6.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JH993930">
        <property type="protein sequence ID" value="ELQ75735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWR1"/>
    <dbReference type="FunCoup" id="L7JWR1">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1304"/>
    <dbReference type="HOGENOM" id="CLU_708200_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWR1"/>
    <dbReference type="OMA" id="PETFGWM"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="2">
        <location>
            <begin position="142"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="390" mass="44608" checksum="507079FBBA49D0B2" modified="2013-03-06" version="1">MGTKILEDSFIRKWYIVCGRGKSGKTSVSAGIGLRLADTTVCNDICRKNCDCKNVRCDLNCPCMRENVTDDKFSEMVCHKPSTMMIERPSSDSIDFNDKIFVDQDINVDTQHNQKYSDVNVSKDEDNIEFRDELPDENPNYCSKCLRKILLVSLDQQDNLSETFQTEIETKPTRIKNNFYVMELNRGAIAQIKENDENNVTILKSIRSLPGVLEALYFSEIIKIAREYDTIIIDTWPSFNTLNFLSFPKELNSLLNKIIGMDKLKNLDKAPFYQKIVDAASTIEKCGMFLKKSAECSFILVFTPEMLSITEANKLITKLAYVGISVNHLLINQVLRPKTECEICTAIETKQQKALERVKNCNINQIYLDFEPNGVRGVTNLERFSRKFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWV8</accession>
    <name>L7JWV8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Structural maintenance of chromosome protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993944">
        <property type="protein sequence ID" value="ELQ75546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWV8"/>
    <dbReference type="STRING" id="72359.L7JWV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1504"/>
    <dbReference type="HOGENOM" id="CLU_001042_9_0_1"/>
    <dbReference type="InParanoid" id="L7JWV8"/>
    <dbReference type="OMA" id="ECAGTTI"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="413"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="243"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="679"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="874"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1042" mass="119464" checksum="5173C0588F5221B8" modified="2013-03-06" version="1">MHESCFTAQFIPVNNPSLIFQSFLLPPMELKQLTITNFKSISKTTLNICTFTAITGLNGSGKSNILDAIMFCLDKGNMRMMRVECYKDLIRAGEQSCTVEMVFTSLVIRREVTREGKSKVYVNNHPASLSTVRTVTAAFNILLIQQGTITKFLHTNDLQSFINYCVGTVNHYKQRLSTVMDKENKLNGVKKQLSDRIAPFFSRLRAERENTISNRKRMGRKKVVEERLAYARRIERLLELVEMQCINEHKKNIKQKLERINRSAQRRQHCKEEKVKMMEMKDEMNALQEREKRAVPVVQPAKTRGKEIEEMISIMEGGMDVVGVDEERLALQEDVMRIERELEGHVLERRSGKSANGNDGSTGICGKNEDSVLNYKNTLLEMSNDVKSVGDNVKKLKELSEKIKFVKNEAWVSRTEGRVFELFTLIDSKYKRAVDTILGNKRNYYVVKSSDLVKDIIKDGNGTFIPLDKIKYSDNKYKGNLLIQKIKYREEHRNAFYFLFNNYYVFDNDKDARSFSFDKKVITVTLEGTVYDYRGVISGGMVNVKDMVGKGEIEKVNRENMDVIREMARLIDENVGRGVENDHGSKGGLDDRNRRGGMSGTAREKVIGNFNGVHGECIADSLIKRLNTGASINTTLSNHYNSCNTFIDTSNKKMEKIRVLVQKGTRLNAINKIIEGKDVNRISELRAELVEERRKEEETKIKEKERDKIIEENDKIEQHNEGVRRRKKEIEEYLKGCRVDEEEEVVDSYEIRYNLKNTLVKLEGRKIEENAGEQIEEIMKEGLEGVEKCLMDKEDVLNNAPARDAQVTTMDTIFGTFLKSGSHNFLDLISALNSYLSVNDCLSFIHGAINKYEQEIKDLAVTKKEMDPKNFDLLEKNEEQLTEIKNKIAKLEIDKKKIMKSINEFEIQSEAKRKTFIDNINNTINDIISVFIPECNINIHNDALNITINNNAVSINELSGGQRSLIAVAMMFSCMDARNCLCLFDEIDSALDLGQTQRVSMYLRDKGCQVVVVSLKEGFYSCADVIYQVYKENNYGKVQRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX16</accession>
    <name>L7JX16_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1060</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
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            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1060"/>
    <dbReference type="HOGENOM" id="CLU_2962540_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX16"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6550" checksum="4CB026EC0555FC40" modified="2013-03-06" version="1">MLLVKSVLLPIATYGCELYGMSTARLAPLQRVIDHALKDVLSCGSSYCRKAAYEELHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX40</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993887">
        <property type="protein sequence ID" value="ELQ76038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0989"/>
    <dbReference type="HOGENOM" id="CLU_3244855_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX40"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="43" mass="5027" checksum="D0BA5682753285FC" modified="2013-03-06" version="1" fragment="single">VRRVVLWFCNDEIKLNVLSLSFEEIVLHCHDSIIRNTDSVPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX48</accession>
    <name>L7JX48_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1002"/>
    <dbReference type="HOGENOM" id="CLU_3224894_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX48"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5054" checksum="FAA084FAA57B3783" modified="2013-03-06" version="1">MLDELKGSATDVISKVFNTYRKIYEHLVEINIMCPVTDQTAHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX68</accession>
    <name>L7JX68_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1145"/>
    <dbReference type="HOGENOM" id="CLU_1856805_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX68"/>
    <dbReference type="OMA" id="IVERNEY"/>
    <dbReference type="OrthoDB" id="10379566at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="169" mass="19914" checksum="93789B7C5BB9D6E0" modified="2013-03-06" version="1" fragment="single">VGVSYRDIISSQNCCFIIFRCSPCSFTRREEMTSNNTNRNNAGIEKRCDRQAQNVTRSTGHPATTSYIIRDKNLRIRTRTCQSNKHLMVRINKRVEDALVVMRRILERNAYDTVYLMIKYGSIQRMDRSTLKMVYDTMGYVVYVGYMPGKMVKEDEYVCLYRMERIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXA3</accession>
    <name>L7JXA3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1674"/>
    <dbReference type="HOGENOM" id="CLU_2198833_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXA3"/>
    <dbReference type="OMA" id="WPVYLEL"/>
    <dbReference type="OrthoDB" id="10308158at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="12247" checksum="1AF0B3B66DB82FDC" modified="2013-03-06" version="1">MLILPGERDAEYVVNADTNEKMFFEPLLKIGSLVRCRIIRAWPVYLELEITHIDGHATNVQYKAVYRPNFIEQDVNAVFLDGSYKYGSDFEGKVVSYGDNMGVVIGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXG8</accession>
    <name>L7JXG8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1013"/>
    <dbReference type="HOGENOM" id="CLU_2265584_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXG8"/>
    <dbReference type="OMA" id="VQVKAIM"/>
    <dbReference type="OrthoDB" id="10480437at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="103" mass="10874" checksum="A5AD3A0285C112BB" modified="2013-03-06" version="1">MLKIDNSVFVLFVLSVLCAIYFSLFSIPLFSTGTKPPSKIVNVEERVKTLEVQVKTICEVLGMKVKAGDGKGNGGENAGEDGNKEDKSVEGVGMSGIPGVPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXI9</accession>
    <name>L7JXI9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_1289</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXI9"/>
    <dbReference type="FunCoup" id="L7JXI9">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1289"/>
    <dbReference type="HOGENOM" id="CLU_027974_0_1_1"/>
    <dbReference type="InParanoid" id="L7JXI9"/>
    <dbReference type="OMA" id="IKFMMRA"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ75761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="269" mass="31149" checksum="13BBE1AD996FB5D2" modified="2013-03-06" version="1">MDNNIIEVWSDNLESSFSEIRKLVQTYNYVTMDTEFPGVVAKPLGNFTSHSTYAYQQLRCNVDLLKVIQVGITFSDCYGNCPARNTYQFNFHFDIDKEMYAKDSLKLLVEAQLNFDKHRLQGIEVEEFGNLLITSGLILSKNVTWLSFHSSYDFAYLMKIVTCNPLPATENEFFMFMNILFPNFYDVKYLLRGSKYLKRGLQEIAEDLGLKRVGVQHQAGSDALLTRDVFFKVKEIFYTKEDITRHAVKLYGIECRADEEKVMVCDLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXK8</accession>
    <name>L7JXK8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1531"/>
    <dbReference type="HOGENOM" id="CLU_1230673_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXK8"/>
    <dbReference type="OMA" id="EMRFEVQ"/>
    <dbReference type="OrthoDB" id="10351309at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="225" mass="26624" checksum="2D0EE1BBDEFA160E" modified="2013-03-06" version="1">MTNHNPRSANKIFFRHTNLLRQSSPSKPSNPSFMSVLSTHINKFLTTLSNNFIQELHKTGTITPRYSALIQNIDAFERTLNQYFHIPRVIHDAVQYLRPKYEVNLNIPQHYGSYAVHVDRRNIIRGLPAVQFKPSIFYTLYKLYGWLTANWENDKKIDRMEQFVIPKYFENKGVCDLRNYESGDVVNGRVEMRFEVQRDGKHYYGRCLADLRNDEIRDYEENEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXP1</accession>
    <name>L7JXP1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0925"/>
    <dbReference type="HOGENOM" id="CLU_1157085_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXP1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="240" mass="27712" checksum="99EF86649FB2918C" modified="2013-03-06" version="1">MDSLLLQKEELSTSLELSDRISSFIMYLDNSPFVNHGIRFIVGFIGLFIFLYLILEVIYSPTTRLRNDLYDEVIAARAFTGNAQPENRNLLHPYSPEISWNSNFELRRLPDEDVDIFLPFPARNADTFSFGHTSSGDSVLSTINELWDDVPPPYTSLDTFTSTSFQDDDSNSSLEDRLRVYAQNIRHRNVYLPSYEEVISETIECEEEYRQSRSYISSLDDSDDEPPSYEEATDLHNNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXU4</accession>
    <name>L7JXU4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitotic spindle checkpoint protein BUB3, WD repeat superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXU4"/>
    <dbReference type="STRING" id="72359.L7JXU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0896"/>
    <dbReference type="HOGENOM" id="CLU_984180_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXU4"/>
    <dbReference type="OMA" id="RINYPVN"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="283" mass="31907" checksum="23E2D36EFD09A399" modified="2013-03-06" version="1">MNLPDPPSDSITDIKVQEDKIHVSSFDRTLRIYKDELLVHKIVHNLPILKIGFLDNDPIFTDIVGDVITPYSRIKTDCGGIQGMSIYNNSIIVAGWNKKLQIIQNDEIQSTVELREKVYAMDRRDNFILLGCSNSTCLLYDIRKIDSIMSKSVAGPITSVALGNCAVIGMLNGKIRIDFSISGTSRAVDTYTFNCHHKSSDNKRINYPVNDLIFNNTLISCGSDGSIVKWDVHSRTMLKEIYRSDLNVSAIERYKNKIVAGFSYNYEQGDKESFSPELRILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXX6</accession>
    <name>L7JXX6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small Nuclear ribonucleoprotein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993905">
        <property type="protein sequence ID" value="ELQ75911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXX6"/>
    <dbReference type="STRING" id="72359.L7JXX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1134"/>
    <dbReference type="HOGENOM" id="CLU_076902_11_4_1"/>
    <dbReference type="InParanoid" id="L7JXX6"/>
    <dbReference type="OMA" id="NAYEECD"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9120" checksum="24ADC1D7148F17E1" modified="2013-03-06" version="1">MHHPSPKSYLEQTMNTDVTLYMRKKKKYLGKLIGMDEHCNVLLDNAYEECDDNVRVEIGRALINGGSIAAIEFFDENER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY07</accession>
    <name>L7JY07_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1403"/>
    <dbReference type="HOGENOM" id="CLU_1778766_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY07"/>
    <dbReference type="OMA" id="NIVVKMW"/>
    <dbReference type="OrthoDB" id="10401412at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="16643" checksum="9E985FAE0C96DF71" modified="2013-03-06" version="1">MSYLITSNIKQKEYLNQHNCYSMTEPPNELSTSINDEKCICKVLTRRFRLVDYTVKSITGNNIVVKMWAGKSQSGGGCGMKSCMNRKRDGMMEITDDIDNEEKREQSQHSGAEDMVKKEIEISTENKENIAEKGEVLKVNLDKHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY17</accession>
    <name>L7JY17_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Drug/Metabolite Transporter (DMT) Superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY17"/>
    <dbReference type="STRING" id="72359.L7JY17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0700"/>
    <dbReference type="HOGENOM" id="CLU_585379_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY17"/>
    <dbReference type="OMA" id="YYGPLAC"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF9">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="521" mass="58748" checksum="7206CF42562630B5" modified="2013-03-06" version="1" fragment="single">VLTCGGKNLNSLDVLIKTCCHKQPCSTQCLPDHPRVSICFTVSLKHSFLLHNKMFLFISSITAFCTKDSDCLVRSRPDVHSMYCVHNTCQKLLSAGKNCTKPSDCASYFYYGPLACSARCRAESECQYDELKSVNSVYCCRAVPEGRECNPGRPNLLNGCESKHGCVQVDGTYKCMGKNMGAWSLGVYLSVQGNLCINVGLNLQKRSYHDPYLRIRGVSVSMFYVGVVVYVAGKVSGFMSYIFGNQSLLASLGAVGLIANSVFAPLINSEVFTWKDFMAIVFVLTGSSVILMNSGRSHKTFTLCELLKMYQKKETLVWFGVIVLLVLFLFTLVKFIEVNSEWSFTNDVFDFMKRDRLYFEETGRILKYSMVVLYVGLSGIIASFTTLFAKSFGEMVDQTLLGDNQFLYGITYLFFTNIVLFTGLQIFWMNKALRHYDALLVIPLFFVVWTLFSVLTAGIYFQDFEYYTLDQFKGFVYGLVIIIAGSFFLVSRVMNSDQVVGKESGVRKVPKKKDRMDTEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY74</accession>
    <name>L7JY74_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1009"/>
    <dbReference type="HOGENOM" id="CLU_474232_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY74"/>
    <dbReference type="OrthoDB" id="2196381at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="575" mass="68122" checksum="E337DF104A55B811" modified="2013-03-06" version="1">MLNLRTIERNRKLVKEFVRETENKLKIRKSAKPDDNKEAPTTTTINRLHAYYANRIGFVDSSIARECAAENIKRKEISEKVENIGMSCSGVLYNLHNNTCFDLKEYFGVYLTFTRIIDLGEYHFSIKEFDLNVFLVILSHDHIDRQIVRFLCKMADDPADYSKEEKKKFYYVLFLGYFYVSKIKNAEYTNDIKRIKDKLYLKTKKMSYLLDTKIVSRYHCDIKPVHDHFLDKIIVKLFVNRIKSEKTASSDSKFFNSCYTMYLRRDKIDFEIFYYFQKNLNITIKTLPHEQHVHFLKNVFLRDTVLYSLTDVRQIIKFIFLFYTNKLAPKIQKKILYVVLDFFHVLSMNYRLIDALLDEMSAFLDNEAVSSVQDDRMKMVINQHAVRSSRCFDDFSTFLIFNSDSFHSTKLLVDHFLNIYKYFDVNYARFMAIIEFLGLLVSKIKMEFLYQIYMALVECLQDIINEFNTFLNSRINGTDSTDLNGIILSLTVNDTEKLKKFVDKFVKTYFKLFTGRTGEEKKKKRKGCARENVKDKKMLNLMGVLRDNEGIVNSYLERCQIDRKYSVLKDKGLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYA3</accession>
    <name>L7JYA3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993887">
        <property type="protein sequence ID" value="ELQ76036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0987"/>
    <dbReference type="HOGENOM" id="CLU_2575552_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYA3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="9240" checksum="5DAE0F139926B26E" modified="2013-03-06" version="1">MLYITLFNNETSNGADNEYFIRTDLKSLFMTSILDEPPSNVKASVNGLGITDYDIINDELDILHSKELKEICIKLKSRDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYE9</accession>
    <name>L7JYE9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LisH motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1285"/>
    <dbReference type="HOGENOM" id="CLU_1541193_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYE9"/>
    <dbReference type="OMA" id="WNTLDIS"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="174" mass="20222" checksum="DDBFADE11C67A7A4" modified="2013-03-06" version="1">MVIKQVDYNKLVLDYFIYQGNQHMANLYARETGQRFYPSSFLALRSKVRDLILSGEPVAAKKALELYNFEFLTTTNLSDHLKKQFAIEKVAKGVHEEALEELKECKLELNDVLEMIVYGEGVDIERWRTCCAEIVNQVIVDEFGEIRNALVEIVEGLDWNTLDISEYYDSEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYI0</accession>
    <name>L7JYI0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative C2H2-type/integrase, DNA-binding, Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYI0"/>
    <dbReference type="STRING" id="72359.L7JYI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0517"/>
    <dbReference type="HOGENOM" id="CLU_113777_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYI0"/>
    <dbReference type="OMA" id="YHIENGH"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="231" mass="26882" checksum="D90F88FBD67435D3" modified="2013-03-06" version="1">MQKTVKPMNNKRAKLTDIDSLAHYRNEFYRNKKLYEINQYKMNREQIVLENLLLNIEEDVLFKERDEVSMEEVLESTEKRFLNNLDCCGNYFDTFNSFAQHRNFEHSNEEESAQDENGAGRERECVGTGSTFSNVHNTINGSSIANFNVSRGVDAENVPVDQQEKCKPYRCDITGCKKAYTSAYGLRYHIENGHVQKDDSNKPHICAFSNCGKRYKNSNGLKYHLEHFHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYL9</accession>
    <name>L7JYL9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Translation protein SH3-like, subgroup protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993837">
        <property type="protein sequence ID" value="ELQ76558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYL9"/>
    <dbReference type="STRING" id="72359.L7JYL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0452"/>
    <dbReference type="HOGENOM" id="CLU_2005626_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYL9"/>
    <dbReference type="OMA" id="MHVLATE"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="124" mass="14607" checksum="35F2BE3E4FED82A1" modified="2013-03-06" version="1">MEDKKTIFRKKMLVILTRGRQASRKAVVLEVLEDERLLVAGFTSKRRNKNRNNKSATMFIKRMNPMHVLATEHVANVDLSVEDVEKVFADMKYKRDTLKTIEQLIEKRADDRNVQWMKKSLVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYX0</accession>
    <name>L7JYX0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0548"/>
    <dbReference type="HOGENOM" id="CLU_143915_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYX0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="18386" checksum="0E4A7240E91CFDC4" modified="2013-03-06" version="1" fragment="single">VLFEIDNCVYIQKWLLQYLGQEERNAKVMNVHLLDRAYWKLKHKIFRKIKGVSFDKWKSIYLEHVKMCSAWLEKMILERTKKIDEFMKTYGISTPTRDSLFENLWQGKVDLSILGENIILKIGFIPKMLYNAGLRNDTVASTSYKRFIMRNRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYX6</accession>
    <name>L7JYX6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYX6"/>
    <dbReference type="STRING" id="72359.L7JYX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1066"/>
    <dbReference type="HOGENOM" id="CLU_276369_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYX6"/>
    <dbReference type="OrthoDB" id="2196406at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1152" mass="132803" checksum="2C4FD005839F70B4" modified="2013-03-06" version="1">MHALLLILFNYTIYNNRNLRTQTFEELTLMANNDKKVSDFARSASNATVDRQGCTGLLEDKERLDGCVNGDERCDGIISGDDQRKEERYRRIEEDSNLKLEINHDTMLNCDVVLSSDLRPNPVLNDPGLDDQGVNAKVTYNTPSNHDIRITPTLNTSYNHKYVPNNDQIMNSNHKLQSRPQSNQSRLQSRLNQQAIKENTTFKLLYKHRKHPYRVLHAIKHVSTIFDFLTRVILDEHTTINYLKIARTLCQRAKTIDDLFRTRDESVTTTETNGATNLHSIVLYLNHVLHEFKHRAEIIALVNTLYDLHSDYFLYVLKEHVIRNDNVKDVLAVVQHNSVHVFIGALGGSRRETVNSFFVDVMIGRARVGSALQLSNVYKLVEYGTYTAKKCAFIVRMHDKRYNVDYKHVVERLHVRLNVHVLYALIRVACDDGRLVAQIRDAMHRIRYDTMKRYGVVLKVLVHLFCARAVHKFDDIALFVHAMHELERVSANFNEKERVMYEELLGVLIEDERCMDVMVDWMMDRVFAAVVQRSKRRCDRRIIRGVEEVVGGVEEVVGDVEGEVSEGRVRRVGGEIKGRLKSVRAVKEGLNHEERLNPEEESNPKEGLNPKEKSNLTKKSELRNRPNLKTKDHVMVRLNTRPKYVQRIKELIKEGNPFITKNVNILLTSSREVLRLADNAPLHTQLLLLARTRASIHSYHHVVLDALSTDDMSTAMLCYAVIRKHPQMMSSDALTRTLLKNVLVNIRRDEPFYACVHLLIKILRSTRVDRRDVLRVAYVVNDRLNTVNKRFRERIGVLYRCMARWMDVRIIVNLMMDNLRVYDRMQRMMGVVVLAEIGVRYFCEVVVVMVMDYGRRDFYVKVGVVRVLERIVRRICRDYGCMACVGFNGCTGCVEFNGCVGCDGRVGSKRGVGSEGSEGSKGGEYCNGPNGCNGHYNHDDYNYNNFNCNNCKPEPEDHTENDNKEHGIHKRTEHIPNNAPKNINYASHKTRDIAPHKRINKKKYKTATTNKTNHSAHKKTKRYKRISTNLMKCILPVLNNALTQNDKTLRKHALQLLKYVLHLHAAAEHLIHLFNLFFVNLLCDDEIKEVFDECFGVFVRRLGSNYVFKYVVGGTEHASRGVRERYLELLGMVHGNGVLVESVDDDVVDEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ08</accession>
    <name>L7JZ08_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related small GTPase, Rho type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ08"/>
    <dbReference type="STRING" id="72359.L7JZ08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0726"/>
    <dbReference type="HOGENOM" id="CLU_1876886_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ08"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="136" mass="16169" checksum="EA0A4018B8542626" modified="2013-03-06" version="1">MSISHCGTRPAELKYDRIRQLSYPNTDMFFICYAINNVASFNNVKHWLNEIKGLEIPAILVATKYDVRDDYTQQDIVTTEMGKKMAKDHNFVDFVETSALERRNLYLLFEKAVEHKIKKDKTFFRLMFEYFCWCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ28</accession>
    <name>L7JZ28_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DHHC-type Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1020"/>
    <dbReference type="HOGENOM" id="CLU_2086472_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ28"/>
    <dbReference type="OMA" id="DDNFNIR"/>
    <dbReference type="OrthoDB" id="5226086at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="117" mass="13932" checksum="E71A34944CDE18D4" modified="2013-03-06" version="1">MTFYVLASISNAIILIISFSLLVSNTILILYNETTIERLTLNEFHAGDDSYRNIFEKDLLRVDDNFNIRDRRLFNPYFLGYIENVREVFGDNYYEWIMPYFTSRGDGIYFRTQSIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ50</accession>
    <name>L7JZ50_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative Heat shock protein DnaJ, Molecular chaperone, Hsp40, DnaJ, Sec63 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993826">
        <property type="protein sequence ID" value="ELQ76723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ50"/>
    <dbReference type="FunCoup" id="L7JZ50">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0277"/>
    <dbReference type="HOGENOM" id="CLU_494335_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ50"/>
    <dbReference type="OMA" id="YNICTIR"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="414"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="565" mass="65500" checksum="D0520B4E03D08C20" modified="2013-03-06" version="1">MKYEYDSTGLVTSYISLFFLTPVVIYTAYAQLFAKPPTKYDCTCTKCLSKREGRNRTFPLILCMLVGVMAYLTYNICTIRMDRRSDVFNPYEVLGLEEGASRRDIQRSFKRLSRLHDPDYFEGPNKHANEQLLKEISRAYNMLKSGKLVINKNEKHHEVIAIPSWLISNGYYSLAVYVLVFGVLFPFFAYLHWKRYTYRNKLGLYYETMEMIYRRMHGECTNTFIGMRALINVIADSKELQEHRYKRQIDMKAFIENNYAVPLRESKKITNGYNVLIDHLFRTGFAHPKDLEYVQKKALAILEGVKMVAFLTNNRAVLDNAFDLERMVVQAVPDPSFAAMQFPYITYNQVFLNKGKSVKELAMMIDKNERKVCMHVYDNLPRKIIRCKDAVVCEKKSVFNFRIELVDDVQNGVDKGNGLNNAERGGSLNNAERRTDNKNNGQNDNNNETTNEDNSQSINDLRTGVLVKQEGEFDYELLNAVGTYRHVPVHAPYFFSRAIVEWTLYALYDNELLPETKIRFSDFVGTKEVILDIPVKERSATLEIVLVCDRYFGCDVKRKVSVKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ51</accession>
    <name>L7JZ51_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin complex component, TCP-1 alpha subunit (CCT1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ51"/>
    <dbReference type="FunCoup" id="L7JZ51">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0320"/>
    <dbReference type="HOGENOM" id="CLU_008891_5_1_1"/>
    <dbReference type="InParanoid" id="L7JZ51"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="540" mass="59315" checksum="6E99A491D2379958" modified="2013-03-06" version="1" fragment="single">VKRPLTQKFLTLEMSETIDPFTGTTRTTAETSRNAITKAILTLTNAIKTSYGALGLDKMCIGTTGDVLITNDGATILTNMDVKDPIANLIIELSRQQDVEMGDGTTGVVLLASALIEKGNELIKRGLHPSVVVSGYKMAFRESQRFIKEKLENKNVNIDAVIDTTLSSKVIHSKHFNELTLKAVKAVEHVDFLGKRRYGIKNINILKKEGGQMSDSFAVEGYAINARPCSTEMPAKMKNVRVALLDFDLGKIRLPLNVNIVVNDPDMLESNRKKEISMALDRVKKILESADVILSSRNIDDVCVKPIIEAKKIGIKRVPMKDLKVLSKALNIAISKTEEIETAQIDEITVEQLAHEDYTILKFGKNLSSIVLRGGNDTLLEEMERSVNDGLCAIKRTLECESVLAGGGAFECALSIFLEEYAFSLPSKEAAAIFTYSESLLVIPKTLAMNAGLDANQVLSELRAFQNNGNQEGVSDCFDYGLDIRTGEIVNNIERGIVEPGVSKIRALRAATEVAISILRIDEVIKIPEAPKKQRKEMCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ62</accession>
    <name>L7JZ62_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0648"/>
    <dbReference type="HOGENOM" id="CLU_3070360_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ62"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="53" mass="6668" checksum="CAFA722FAB2A6C20" modified="2013-03-06" version="1">MNMKYRGRGMNWLEKKGERMINENEVGLNEVIERMVFRKEWKEDNEEEEYKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ75</accession>
    <name>L7JZ75_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993818">
        <property type="protein sequence ID" value="ELQ76748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0257"/>
    <dbReference type="HOGENOM" id="CLU_1769394_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ75"/>
    <dbReference type="OMA" id="FYEFAWS"/>
    <dbReference type="OrthoDB" id="10339082at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="147" mass="16892" checksum="3AB9DF8E5BAABD59" modified="2013-03-06" version="1">MRTEVIALLTNGCNIVIQFVVFGLILILEKVQVNQDAYVEISITMLFGHILFIDGVLSKNVYQIWSYSIFLVYLCVMIILRGFCGVGTFIFIFLILVWYVLLVINIIVNLVFFRLLFYEFAWSSYALLGANTQINGKCSFLIELHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ77</accession>
    <name>L7JZ77_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lecithin:cholesterol acyltransferase (LCAT)/Acyl-ceramide synthase</fullName>
            <ecNumber evidence="3">2.3.1.158</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.1.158" evidence="3"/>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ77"/>
    <dbReference type="FunCoup" id="L7JZ77">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0977"/>
    <dbReference type="HOGENOM" id="CLU_016065_2_0_1"/>
    <dbReference type="InParanoid" id="L7JZ77"/>
    <dbReference type="OMA" id="GGGSNWC"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046027">
        <property type="term" value="F:phospholipid:diacylglycerol acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="549" mass="62734" checksum="9F8FC905410C8A58" modified="2013-03-06" version="1" fragment="single">VQPMKLTISHHIIIALVSMSIIMFVFYQTRTLKMQDALKIISSKLDTLENLIGLIKINENEAEPIPSNVIKELGGTKKHPVIIIPGFASSHLEIWNSHDQDLCFKKVWGSLDGLRHMLMDKASFLSHLKLKSNGKDPENIKVRACKGLESCSHMLPGYWVWSKIIRSLSLLNYDSNSLVVFPYDWRISFEQLEQRDAFFTRLKNEVEMLRRIHNEKVVILSHSMGAVIAHHMMHWVEEKEKGWCDQHLQGLVNIAAPQLGVPRSFTAIISGDWGVQNTSRFNFLKIFFSQSERAILLRNWESVMNLLPKGTNKIWKHFIGRTLKKDDQKDQAQEQPKQESKDRKDDVPLVKFTDSKAGIYVEQVIHFVKVLLGRDITRIKYFDPTQTRLPDAPNLTIYSLYGIDSETEGGYCYKTAGKTLNNRGIPYFIDRDAYDEDMRCKNGVFVVNGDGTVPLISLGYMGRKGWKNKSINPSNVQTIVREYRHRPVNILKDLRGGPSSAGHVDILGNTNLIIDVLRIVSGTGKVKDRVHSELDEIIKDIEEDEKVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ93</accession>
    <name>L7JZ93_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993815">
        <property type="protein sequence ID" value="ELQ76768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0239"/>
    <dbReference type="HOGENOM" id="CLU_628795_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ93"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="387" mass="44449" checksum="5F6574B728F44310" modified="2013-03-06" version="1" fragment="single">VHPVSPSDVVGLTMLICKTMMGFMGLRERVTSSHMVGPEGHELDLGITGPKFRRDTFITDIEVFAGLFSLTMPFPEPERVKCFNKHIDRSLFVKKFDSSRCEVDMQALVLYIDDFYTACRVTSSLCKYALGFISLCMRPEYGDFGSILSDSPTSLFVELEKFKATGMGSAPACALREPSDFLLWYDRLCSLRALFVNYLTTRNGRFRGLVEMCRIAKEVEKDIEKLESEYNAYLDSQEGFVQDYFRTWGLVGGRGPLFIHSVPMIDVYQACTDKFKNKVNSLVARDDSPVVALMQNLRENGGVLPPDLVERRERFWEWQKKIKKEQKPMRVPINDLLLEFQSEDSGAFVFERQMTFMNLHQAIIERVARCWLNSSLYNDDQSMCNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZD4</accession>
    <name>L7JZD4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L13a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZD4"/>
    <dbReference type="FunCoup" id="L7JZD4">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0374"/>
    <dbReference type="HOGENOM" id="CLU_076922_1_1_1"/>
    <dbReference type="InParanoid" id="L7JZD4"/>
    <dbReference type="OMA" id="GMLPWKT"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="24418" checksum="C55F7DC5326B6683" modified="2013-03-06" version="1">MYNPNRTYEHNNQSREIVINAKDHVAGKLATFVAKNILEGVPVTVVHTENIVFTGPIERGVGRFKDFLNKRKLTNPLRGPFHHRSPAMLFTRIVRRMVPKKKYKGQCALSLLTVHDSCPDDLVATQCMVCPRAMLKYTADPIRRFYYMKDLCSKFGWKYFNEVERQNVIVEEIRRKAKETKEKIAEKVNSIKESDKFKRRVEELMAQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZI9</accession>
    <name>L7JZI9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993829">
        <property type="protein sequence ID" value="ELQ76720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0286"/>
    <dbReference type="HOGENOM" id="CLU_1321723_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZI9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="208" mass="21117" checksum="DEB92F038EB1B098" modified="2013-03-06" version="1">MEMADVSGEHNNNNHGPSIAPSGPAEQSPSANGNHGPNVTPSGPAEQSPSANGNHGPSVAPSGPAEQSPSANGNSSPIIIPSNRVKQAGEQNSSGNANHTPGIILDDPVEQAGEQHPLGNSNHAREPNGNRDRSPTTLRRKTSGDEIDRNHQENDGEGNNSENKSNIGAANGDGVSSEAVGENQTPESVVGLDAEAQNASETSTAGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZJ0</accession>
    <name>L7JZJ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding SAP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0498"/>
    <dbReference type="HOGENOM" id="CLU_2086613_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZJ0"/>
    <dbReference type="OMA" id="RFACNKS"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="117" mass="13429" checksum="21EC2425670A0038" modified="2013-03-06" version="1">MDFKKLTVAQLREECKKRDINTVNLKKTELIEHLLRYEDGNKTAQCGETGESSSAAFESKSFDELSESEKIQARIRRFACNKPGENTGDIGALDAVYAKELQEREERQRRFSRPADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZK0</accession>
    <name>L7JZK0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZK0"/>
    <dbReference type="FunCoup" id="L7JZK0">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0151"/>
    <dbReference type="HOGENOM" id="CLU_027694_1_2_1"/>
    <dbReference type="InParanoid" id="L7JZK0"/>
    <dbReference type="OMA" id="KWPTNPL"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="206" mass="23799" checksum="4DB38C3D8FCCC95B" modified="2013-03-06" version="1">MSSIRKYEKRLEGAKFRIINELMYKNEKIEPEQLLEYHIGYRSQTQKWPVNPIDTIIEHLKTKEYSKIADVGCGEALLAQKIAHVDSYDYYPINESIIKSDINEIKCEDAEYECAVYCLSLMKNNVGAAMKECNRIVKVGGCVVIAEVLSRISSLNEFYTQMLAMGFKKNSVLASNDFFIIVEFIKVKDCDKVVDMFLKECVYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZL9</accession>
    <name>L7JZL9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993807">
        <property type="protein sequence ID" value="ELQ76884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0125"/>
    <dbReference type="HOGENOM" id="CLU_1490010_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZL9"/>
    <dbReference type="OMA" id="SNHERHA"/>
    <dbReference type="OrthoDB" id="10434952at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="20674" checksum="240E8068CEDE6CDB" modified="2013-03-06" version="1">MDNQPRNIRQTSIDLSNHERHAEERDYHIQPTILEVKLKFTKRNDRYTVDYEVLKDLNILRIAEILIAVDDGRAQGCKVLTVYPGNYEDGYGGNNMRFSNAAPSYNGQDGMNNGDGGSDAYDPITHINSAVGDDALDLCDRAFRTAIGYGNKDEIRFMDEQNEYNYNRKLKDTKHDGERMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZN1</accession>
    <name>L7JZN1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993816">
        <property type="protein sequence ID" value="ELQ76765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0244"/>
    <dbReference type="HOGENOM" id="CLU_1760068_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZN1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="17313" checksum="1252C6B39D95D231" modified="2013-03-06" version="1">MMVSDEEQKMILINSLENQIKNISLIFNIIHDHIEKLEEKSRINQEPIKEECKDIISTFKTGTKTYSTTMKKLMDDVQDDQSFYLERTDDLFEAKDTYVEIMDETFYILGGEYPFEVEIAAKFKEGHTALNQEPDIEGIFAGGEKWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZZ2</accession>
    <name>L7JZZ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0703"/>
    <dbReference type="HOGENOM" id="CLU_2892290_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZZ2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="63" mass="6982" checksum="D0927E52A67EAA07" modified="2013-03-06" version="1" fragment="single">VNLLSYDGQEMIVGVDPWRGVWIEGLFNDESRAFSEEAVGKDEEGVFNDESRAFSEEAVGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K028</accession>
    <name>L7K028_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K028"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0058"/>
    <dbReference type="HOGENOM" id="CLU_2764970_0_0_1"/>
    <dbReference type="InParanoid" id="L7K028"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="70" mass="8135" checksum="AF097A579F3E6A05" modified="2013-03-06" version="1" fragment="single">VNNIRTGVLLIPDQCYISYSLMVCFLVVYLALSYFVTIRPFCFESRVDLSKKVIAEDEDEKVRVRVVKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0D6</accession>
    <name>L7K0D6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993805">
        <property type="protein sequence ID" value="ELQ76926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0D6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0080"/>
    <dbReference type="HOGENOM" id="CLU_2910603_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0D6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="6983" checksum="39F95F81E75ADF40" modified="2013-03-06" version="1" fragment="single">VNDNSVMMEQMERCSGVDDKNVMIKQIEWCSGVDECMQVNEWENATQRIRGVGLSQSTAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0G3</accession>
    <name>L7K0G3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Histone-lysine N-methyltransferase</fullName>
            <ecNumber evidence="15">2.1.1.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_0401</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.1.1.43" evidence="15"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0G3"/>
    <dbReference type="STRING" id="72359.L7K0G3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0401"/>
    <dbReference type="HOGENOM" id="CLU_487991_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0G3"/>
    <dbReference type="OMA" id="SLPRYEC"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE TRITHORAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838">
        <property type="entry name" value="HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="13">
        <location>
            <begin position="424"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="14">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ76682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="559" mass="65286" checksum="56459EB21F350A1F" modified="2013-03-06" version="1" fragment="single">VKIRPIMVFQWFYYNDYVNNPALQLGSLQINGTNGTANTWKKKIDHNLLKNIIKIERIYDIPEKIYNELVEQVSDDEEPYPLLTQLDIMTSYYCPKCNQKYDNHDYTVKMVHCDECTRWLHIECENITWREYAKFGSLPRYECMLCREWKLICENRKLEVLNSNKKNKNGILKTDKYNSAQKNNHQGVKQPENGPSRLSNAQKPGSSKFWMHAADDRQIKKNTEHCFVAIEDDERCANCKRIGATIKCLFCKDRYYHVPCAKAILVCNLVVPSCGKHRITYRFPYVGINTGLRYNNYVYYREDWYGVIINNDFLERRGDYLYLNDRLVQVCALDKIFGKKYSVEELSLEQLFGLYGRGYAYFTEKCMSRPDILSNILFDANIEEMVRSLDERPEYSHDTIQCSSLNAIKVNPTLTHLISHLRCSRPKLSKSAVEGYGLFSTRLYDKDEPIIEYVGELIDDYEADKREKIYKDRIYMFRKNSKIILDATVVGNLAKYINHSCEPNCYATKVICGTASCIIICAKRIITKNEELSYDYNLSKGAIRFECRCNSSNCRGTLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YLW7</accession>
    <accession>L7JS96</accession>
    <name>ISU1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName>Iron sulfur cluster assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Iron sulfur cluster scaffold protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ISU1</name>
        <name type="ORF">THOM_2800</name>
    </gene>
    <organism>
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="452" first="624" last="628">
            <title>Localization and functionality of microsporidian iron-sulphur cluster assembly proteins.</title>
            <authorList>
                <person name="Goldberg A.V."/>
                <person name="Molik S."/>
                <person name="Tsaousis A.D."/>
                <person name="Neumann K."/>
                <person name="Kuhnke G."/>
                <person name="Delbac F."/>
                <person name="Vivares C.P."/>
                <person name="Hirt R.P."/>
                <person name="Lill R."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18311129"/>
            <dbReference type="DOI" id="10.1038/nature06606"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitosomes, which is required for maturation of both [2Fe-2S] and [4Fe-4S] proteins (PubMed:18311129). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISU1. In a second step, the cluster is released from ISU1, transferred to a glutaredoxin, followed by the formation of [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the core Fe-S cluster (ISC) assembly machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">It is unknown how the different localizations of several ISC components to mitosomes and cytoplasm can be reconciled with the usually tightly coordinated function of these components.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="EF571314">
        <property type="protein sequence ID" value="ABS58598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YLW7"/>
    <dbReference type="SMR" id="B0YLW7"/>
    <dbReference type="FunCoup" id="B0YLW7">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="72359.B0YLW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2800"/>
    <dbReference type="HOGENOM" id="CLU_079283_5_0_1"/>
    <dbReference type="InParanoid" id="B0YLW7"/>
    <dbReference type="OMA" id="SMVTEMV"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382933" description="Iron sulfur cluster assembly protein 1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q03020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9UTC6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18311129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="18311129"/>
        </source>
    </evidence>
    <sequence length="138" mass="15064" checksum="7F868AB2BEAC13E8" modified="2008-04-08" version="1">MLTPFNNFFQQRQNYHSSVIDHFENPRNVGSYDKSANDVGTGLVGAPACGDVMKLQIKVENDIIKDAKFRTFGCGSAIASSSLATEWIKGKSISDSLKITNKDIAKKLSLPPVKLHCSMLAEDAIKAAISDYQKKNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQV3</accession>
    <name>L7JQV3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3218"/>
    <dbReference type="HOGENOM" id="CLU_2122792_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQV3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="114" mass="12962" checksum="9C6F851BFBA84932" modified="2013-03-06" version="1">MQVILISLFLYSRQQPNNNPVIDDLTYLNTEEHGNGTRTNNFPTINDEKHGNGTRTENSPTINDEEHGNGTRTDNSPTLNDKERNKKTKRAMHVNPRDKDLSGYSGHNVMLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR52</accession>
    <name>L7JR52_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994097">
        <property type="protein sequence ID" value="ELQ73919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3159"/>
    <dbReference type="HOGENOM" id="CLU_1950313_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR52"/>
    <dbReference type="OMA" id="KTRTNKF"/>
    <dbReference type="OrthoDB" id="10253334at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="129" mass="14787" checksum="D411088A54BB92C2" modified="2013-03-06" version="1">MSTAQSQFPSYTAILHNIQALEERSNHPLNQHKLDILHAMLALAKLKHANDTIKVINDTAAKLLAVYERLCGNAKTPIERKDENVPVRKARSNPKTKYRKRAEELLRKKAQGRKVMLSTRTTRTNKFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRD4</accession>
    <name>L7JRD4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3061"/>
    <dbReference type="HOGENOM" id="CLU_1361332_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRD4"/>
    <dbReference type="OMA" id="CTEASKD"/>
    <dbReference type="OrthoDB" id="10458985at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="201" mass="23564" checksum="7B770F24BD15FBBE" modified="2013-03-06" version="1">MYKLHIKRAIEVLFIAFLAFLIVCCTESLKENRRFLSFVKNNEGYQEMLGIRKDVAYVCNLNKSETRNIATYDLFVPETFNARNSAINSLLSNNNHVIKCFIVLRNKKVIPPFYKLTIFVNIGLLFLRNYELASTKCFLHQLLRGTRNGKNMTINCDKNRIKLYIGDDKGDNHKHFVYKCKEDASYDITIFVLSYLFKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRJ8</accession>
    <name>L7JRJ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2994"/>
    <dbReference type="HOGENOM" id="CLU_1210587_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRJ8"/>
    <dbReference type="OMA" id="NITHLGM"/>
    <dbReference type="OrthoDB" id="2187049at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="233" mass="26491" checksum="D64B4CF7BFF2E3F9" modified="2013-03-06" version="1">MFLFISVILARCSHKEAYRLPIYTYLDQGSVMAIARESGVYPWMSEKEMVADFLNQTFQEVNSALIQYGVHLQLSLKDNIHHTNFSLPCGSISPISTFMKSKNIDRRKSSDSEHIRLFIVYCDNFLGHLGLNEGIYTEYNGCRIDGGIMYVNNDILKVKIKDVLFKIVTRSNITHLGMDFERNLCQLVNECISGAIKPIGSRESLENVSFGSANSDDEIDLHVFKYDITAQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRM2</accession>
    <name>L7JRM2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_3136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRM2"/>
    <dbReference type="STRING" id="72359.L7JRM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3136"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="L7JRM2"/>
    <dbReference type="OMA" id="KMRPFES"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ73940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="309" mass="36580" checksum="18FAEA77BB14A0ED" modified="2013-03-06" version="1">MHKQESAAMRLDDYRFLEKLGNGTHGTVYLLESRESKPKLVVFKSVSSKNLKYALNEIEIIKSLSYKRIVRFYGSMSSNNGMYIMMEHANYGDLERLNCFIREKNLNIDKSIIWTIFSQLIDALAYLHRNRIIHRDIKPGNILLNRVKGRSCNFLQVKLCDFSLSKRLDDESKSNDGMIVGTPYYMAPEIIQKKAYDYSVDVWSMGVVMYELVSKMRPFESESKKELKRQIVFQEIRVLPNCRDFFLKKIVLECLRKEDRISAEELLRLERVKYHLIIAEHRLKTYRLERLERKIHRMSKEKGLEQTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRP1</accession>
    <name>L7JRP1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60s ribosomal protein L34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRP1"/>
    <dbReference type="FunCoup" id="L7JRP1">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2995"/>
    <dbReference type="HOGENOM" id="CLU_118652_1_1_1"/>
    <dbReference type="InParanoid" id="L7JRP1"/>
    <dbReference type="OMA" id="WMNWILV"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00349">
        <property type="entry name" value="Ribosomal_eL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047868">
        <property type="entry name" value="Ribosomal_L34e_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="12301" checksum="C57CA70B7E74EBCF" modified="2013-03-06" version="1">MVQRQTVRSHHTYRTRSNRMVKVRTPGKNLVLHNAKKRGKLPKCGTCHKKLLGIKMARPADFSRMKKHNRTVNRVYGGVLCSGCVRDKIIGAFMDEELKRAEIGGKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS14</accession>
    <name>L7JS14_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNARE protein Syntaxin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS14"/>
    <dbReference type="FunCoup" id="L7JS14">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3211"/>
    <dbReference type="HOGENOM" id="CLU_082505_1_0_1"/>
    <dbReference type="InParanoid" id="L7JS14"/>
    <dbReference type="OMA" id="ENTRNMN"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ73836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="199" mass="23412" checksum="1897F46A08FF7666" modified="2013-03-06" version="1" fragment="single">VYTYLEHCDEKDSSTYNAIKEQWTTLTHNLTQVVSDFRYVQVEHNNREKEMLREQYLIARPEASEKEISELMTTNNAADVLKNAFINDNTHDLEYRQAQKRLEDIKVIVDYIDQLCQLLRDIDQMVAGQADFVDRIEIDVSVSRENTRNMNVNLRKTLKSTRRWKLFKRILLLIVGVALLVLIIWVFNSVVKPVFFSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS47</accession>
    <name>L7JS47_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein geranylgeranyltransferase type II, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3246"/>
    <dbReference type="HOGENOM" id="CLU_457224_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS47"/>
    <dbReference type="OMA" id="SAWYYRE"/>
    <dbReference type="OrthoDB" id="10614235at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="597" mass="68741" checksum="C5FE128715914523" modified="2013-03-06" version="1">MIIHNTQSKNHTENNDLEALLSLKANHSSKDELIRLALLVPDDYAVVNELKRVGRDGMVGVSERMIGMNVKSYSAWYYREWVMRGDEERSYGEEKKYDEEKSFDGRLGRDEEKSYGEEKSCDEVDRINNNVEVNVNKNNVEVNNNTKVHNNNVNNNINNNNNNINNNNNINNNNNINNNDNINNNNILNAQECGQYNHTVQQKIQQYDNTNLSTIKQGPLLNQPSTQQSQRNKMLIKQLLIHDSRNFHCWKFLLSTNNTQHFATFCIKRDITNYSALHYLNAHTKTYWHALLMAQNEGMYYKLKYPQVFSVRMMPRCRIVAFLFRTLFYGYVWVGCVRRVVEGEVYVEVGDVDGGRVEVGVVGGGVMYRGWLEWGCGGDVIVEDGGGDEGDEGVVEGVVGGGEGDIIVVGVDEGMDEEIVEEGDRMNDDKVGYNMGDEEIVEGVNTLNEEERRNTSDKVRINAFKRVEQLNTAANKRNTNIDKQKCTNKRNICNQQPNRTCQPFNASPTCQSAGHATNNRCSYNHHVIKMKFNSEEVVLNDLIGTNRFLMVRVLERMNTHRAVMIDELKRMDGMRMAYYDTMDWWEVEDTYFERVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS52</accession>
    <name>L7JS52_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS52"/>
    <dbReference type="FunCoup" id="L7JS52">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3251"/>
    <dbReference type="HOGENOM" id="CLU_1220492_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS52"/>
    <dbReference type="OMA" id="INTFSEC"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ73876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="227" mass="26397" checksum="4556A09EAA264F66" modified="2013-03-06" version="1">MLQLETVPPVVLAILLCASVIPLLGLLSPQFTMYFVYDKSYLKRFEIWRLFTGIFVTGVSISLIMRLYFIHKFSSLILEYNCRIDHVPTEIELAFFMFTMFVPLMIGNQLEGINTFSECIPIALIRYFSELVPDNFRLNFFGTIMSAKTYSIVSLAIDYVLNGGRSKVYYGFLHALIYVYLRKKVLRVPAVFVEMIERAKRIKLERLFRTPEVGRRLGGEKKNKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSB1</accession>
    <name>L7JSB1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2757"/>
    <dbReference type="HOGENOM" id="CLU_731942_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSB1"/>
    <dbReference type="OMA" id="KELDCND"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979094" evidence="3">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="378" mass="41712" checksum="F3AC3A7709EBC41A" modified="2013-03-06" version="1">MIQKLCFIFLVCLTDLAHAADASGSSTPVPTQNELLSSLIPADVLARVQSYDALVSDLGSDASVFWNFVLEFYFKIAFTAHHMNDGTSEMKSALCTDEYKESIVLVENLLATFIPGLRQPGIQYTPNTIADALTLLSSIRGKDNTSVRFISGSPRPSTPDATLLENAAKVYEDMKATPKTDKSAKKIKNVSDTSKMTPQQKSQYMLNLMVLSTNAMKVIDKVTPEEYFTFDADQQDEFKRMVVFAYMTYGDGSIPFTGNKEDLRFDPDAAFFGNSSTPLERMFIYMRSFQTDGLHDGTPKYNLKEALSKSQKTILVSTPVDPMASKPTGDKKDDASASKPESESKSWSKLKWVFIIGGGLLVLAAVGGLIYYLIKSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSB4</accession>
    <name>L7JSB4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2762"/>
    <dbReference type="HOGENOM" id="CLU_2518848_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSB4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="9923" checksum="6F6E0201EE40DA80" modified="2013-03-06" version="1" fragment="single">VFRILILITEDAIQTQRRGYLFLMTSTNYTAVVINTAHAGRARALSQTAKIFYIYEFLNCKIIRHPFDVLHLRTLPYHTPVPKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSG8</accession>
    <name>L7JSG8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E2F-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_3089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSG8"/>
    <dbReference type="STRING" id="72359.L7JSG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3089"/>
    <dbReference type="HOGENOM" id="CLU_095032_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSG8"/>
    <dbReference type="OMA" id="HCDTNEE"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="9">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="8">
        <location>
            <begin position="77"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ73996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="207" mass="24543" checksum="2C3A7A8B2EBEE820" modified="2013-03-06" version="1">MKELFSECLGSESRRDGLKQISVSIHNLLLNNKDITYQKICSSINTSNTNTLRRRVYDVLSVMRSLNMVVKAKRCYNLVRRNLLCEKRMVVEEKRKQLEDLQHMKEVFEHIVLKNAFKTHSLSLDRFYLPFMIVVAEKDSNVHCETNEERTFFKFRSSKPIKLVEDLDILKELYKNNEEKEAKKPYLYENNLKKFKEGFGGAFDYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSL3</accession>
    <name>L7JSL3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative SAM-dependent rRNA methyltransferase SPB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSL3"/>
    <dbReference type="FunCoup" id="L7JSL3">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2818"/>
    <dbReference type="HOGENOM" id="CLU_009422_8_2_1"/>
    <dbReference type="InParanoid" id="L7JSL3"/>
    <dbReference type="OMA" id="SWERDSY"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="9">
        <location>
            <begin position="221"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="553" mass="64558" checksum="37080FB5668E786F" modified="2013-03-06" version="1">MAGRKKIGKKRLDKYYHLAKEQGYRARSAYKLIQLNKKFNFLQSCSSVVDLCCAPGGWLQVAVQHNIPDIIGVDLYPIKKINNVKSIVGDITLSGTVKEILNIAGETDCVLHDGAPNVGVCWEQDAFEQNELVLHAIKISTKILKKDGIFLTKVFRSKDYFSILWVLNQLFESVVSTKPISSREQSAEIFVFCRGYKKPAKIDDKFFDANHVFKEKEINENCYKVIKFSEFFNSEDPKSVLETYSKMLIDVKGELFDKVFDQNYKTMLDDLKQIGKHDMKKILKKREKLIKYIQNGEYIEGLDVPVKETVVSLDELPEESKLDQIKREMKKKQRDEKKREAHSKIKCAKSKVFEKLASIDNFFEDRLFQDNLSKENKNDDENKSKTVKKAANIDGIDEMSSDEESLELNSDDKRLIVEMKNDREAFELRTVNKYALNDTSDLPKFYMDEQKNFNQLKSTIDDKNYKKVNKKQQEVMNRRIRRAMKFKKEIMEEISDENDRPRRLFKSCLKKSKKKPKVVVCSKGKPARTMKGRVKYVDRRMKKDLRKQKRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSL6</accession>
    <name>L7JSL6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSL6"/>
    <dbReference type="STRING" id="72359.L7JSL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2568"/>
    <dbReference type="HOGENOM" id="CLU_1230725_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSL6"/>
    <dbReference type="OMA" id="NNCYGYF"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF117">
        <property type="entry name" value="LP05237P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="223" mass="26087" checksum="FF2ED9BCDE965570" modified="2013-03-06" version="1">MFGKVIVNITTVLLVLNNCYGYFKDRKNKHYRYYFLILCLFLVFDSLFSYLTNLVPFFQIAKFAFIIWLSLPMFNGPVFIYNFYMKKIFVRFEADIDLQLEMARKKFMDTFVERLNQAYGKCYQYNERLLGYNGKSNERASLGEPGPQEIGGELMDNARNEALESAKDVVDNTSYVQKENLDKLNASSDVEKEMNDLGRFVGRNEGSYNREEKMENDSKYAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSV9</accession>
    <name>L7JSV9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2688"/>
    <dbReference type="HOGENOM" id="CLU_2005625_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSV9"/>
    <dbReference type="OMA" id="RWKVYIM"/>
    <dbReference type="OrthoDB" id="2186785at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="126" mass="14498" checksum="2A4248DBDF80E1F3" modified="2013-03-06" version="1">MRMACCGMSLAPKYEFEIKNFIIPSTHIQGLCFFVLLASLCLVSCINELVTDYINEKMAVHAEKLKHRRWKVYIMAVNFVTVFINFIMMMVCMTFNVWVVCGVILGKLIGRVNSRRKCVSKCDICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSX7</accession>
    <name>L7JSX7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3222"/>
    <dbReference type="HOGENOM" id="CLU_1705494_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSX7"/>
    <dbReference type="OMA" id="VLRNNCR"/>
    <dbReference type="OrthoDB" id="10349419at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="17559" checksum="3D0AE20DEADF16A5" modified="2013-03-06" version="1">MPTYFHNTPTCRFYVSSTLAENIENDKSLEIVCNHGAFKHHLEKYFSPLFNYSKCQVVVKIHIFRGNEECFGELVNAVSITILQIGAPIPYFLVGVTLCDANQVYHLVLRNNCRLIGIFGCGKFNKKCLEGIKTRCGEEVEKIRGVLQEIVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSY5</accession>
    <name>L7JSY5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSY5"/>
    <dbReference type="STRING" id="72359.L7JSY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2502"/>
    <dbReference type="HOGENOM" id="CLU_019521_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSY5"/>
    <dbReference type="OMA" id="CSFARRS"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="319"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="482" mass="55832" checksum="D0A2772EA97BA500" modified="2013-03-06" version="1">MSFSLEFLSTRSGKALLLKQETKHYLFGYYEGFQRHSIERNIRLPKITNVYLFEDHQVIPLLGFCLTVADMGREALWVYGTEKVKKIFQNACSFARRSKLKMTFSNNNTEVIPIETSNGMNYVIQLPKIKGRLDIDKLDRDFPVKLRKDLKDRKKVLFNGIEYDGNNYMEEDTEIGDICILYTITNEEECLAQLKQFNIKLFVCMNRDCLVLKKHYENGHFVLFEENNEIEYKSFFELQKKLNKIDANFLLPKKSVTKIDAVSAENASNGDRKMIYGLTDSHNINFTKKQPFVFHEDEKWIEQIIFLGTGSAIPSKYRNVSSIIYEEDNCAYLLDCGEDTLSQIDRVYGDLRILEKLKLIFISHSHADHHLGLYFVLKKIQHKVVVLCPQKVKNFLNLFDLDATFFVTDKNKKAEITYLSFNLNDKAIKVSICPVDHIGDSYGIKLQAAHSIAYSGDCRPSFMFAEMAKKSRCNDTRGHIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT02</accession>
    <name>L7JT02_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT02"/>
    <dbReference type="FunCoup" id="L7JT02">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2472"/>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="InParanoid" id="L7JT02"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="2532770at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="100" mass="11000" checksum="9C71DEB585E903FB" modified="2013-03-06" version="1">MSGRGKGGKGLGKGAAKRHRRTTPKSFELGKPAIKRLARKGGVKRVSKDCYYVIATRAGFFLENLVRCAIEYCVVARRKTLSVCDVMNGVKKMGVKMMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT23</accession>
    <name>L7JT23_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor 5 (EIF-5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994039">
        <property type="protein sequence ID" value="ELQ74465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT23"/>
    <dbReference type="STRING" id="72359.L7JT23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2612"/>
    <dbReference type="HOGENOM" id="CLU_088630_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT23"/>
    <dbReference type="OMA" id="ESNHRIM"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="6">
        <location>
            <begin position="13"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="294" mass="34670" checksum="8F82EB3B11C13496" modified="2013-03-06" version="1">MLIPINKNTKDPFYRYKMPHLITKQQGKLKNTKTVLVNIGQISNALKRKEALLQQFILYELSVNSTVKDNMFMLKGDYAASEIQNIIYGFIELLVLCKECTNPETEMGVEGNEVSLCCYACGCRRVVESNHRIMSYVRKNPEMAEYKCYGECDDENDDIRNEEKPVPERENVLSFERSVQQNLNDNFLTFYTDNLPLKREIIKASFNTLINDRERLIIYEKVFKEDEEALTLFFENLEIFLVENDKIKELKNILDSMPFLNQDDFKYFRKKSVVVDKKDSVRIRNTLMNYINYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT83</accession>
    <name>L7JT83_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2853</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT83"/>
    <dbReference type="FunCoup" id="L7JT83">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2853"/>
    <dbReference type="HOGENOM" id="CLU_043736_1_1_1"/>
    <dbReference type="InParanoid" id="L7JT83"/>
    <dbReference type="OMA" id="DHDQRMK"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="305" mass="34242" checksum="B39F6F850893F395" modified="2013-03-06" version="1">MSLRLKKNLPFCRDCQSDQYITDDTKTGAVLCTNCGCIIENTLIDEKTEWRTFDDSANDPSRVGGPNNPLLGTEPLDTMIANIGNLHSYTLNRTQMKSTMRGPERQLINGFNLISAYCDRSNISKTISDRAKLIFKRVDEKKILKGKNLEGVVAACIYIACRQEQSPRTFKEVSVLTAVPKKEIGRSFKLIFPHIEKLQCVTTDDIVARFCSDLNLGIDVQKIAVQISKNVIEKGCMAGKSPDSVAAAVIYMITYIFPNLKGVQKDIQYVTNVTDVTIKNTYKELMQYKEDILPKEILSKARLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTA9</accession>
    <name>L7JTA9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding protein required for biogenesis of the ribosomal 60S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTA9"/>
    <dbReference type="STRING" id="72359.L7JTA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2478"/>
    <dbReference type="HOGENOM" id="CLU_581662_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTA9"/>
    <dbReference type="OMA" id="CTKRRNT"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="456" mass="51173" checksum="0042E61ED0DAFF2A" modified="2013-03-06" version="1" fragment="single">VQKFTPRMPTLFLLSKNTSATHKYVLKDLVKFVPNAIKESKCNGRKEIQELMSIHECDTLLYFECTKRRNTMWLVKSGGPSIECNVDVMFSIDRLKFLVNTYLNVGHVLLFQPVFEDNCELKALKNVLTDIFRREDELCERAMLFAYEDGKVFLRNYKLDDELQEIGPRMVFTVRKVYEDEFCGNVTYENLDLLEGEEKANDGGNVQNNTQDAHSNEAAPNLPDRIESQSTADVDKNAEIKNEDILDRSEQGKAIECINGPNEHIETAGSISNPLEDNSCAPVGDEVSTPVTRAGKKRAAAPTNEKVAKTAKRIAKPKAELPVPVPIETEPVLDESVSVPAKKRAPIVKKSTSKTATPRRTTNYKTKSATPSRNKKNQTDNSADVPTKEAPVIANEEPVPVKDATTKAKRARTAVSKNNDQREEEKNVEEKENNEESKNIHQKQGNKKAVKRGNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTJ9</accession>
    <name>L7JTJ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNAse L inhibitor, ABC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTJ9"/>
    <dbReference type="FunCoup" id="L7JTJ9">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2265"/>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_1"/>
    <dbReference type="InParanoid" id="L7JTJ9"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:translational termination"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="74"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="368"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="604" mass="69279" checksum="B08E60E27C9AFA5F" modified="2013-03-06" version="1">MKEREQNKSKRAAFVKPGLCKPHKCRLECKKTCPVNNVGKKCIEVTNTDSMAVIHENMCIDCGQCVKKCPFNAIEIMNLPTSLTREITHRYGQNLFKLHRLPIPKINCVVALIGTNGIGKSTTIKIMSNGLKPNLGIFKNSVSWQDIIKNFKGSELHGYFIKMLEGKIKCAVKEQYIDLIPGELKKKMKKDRLLVQEFIKDKDDAYTKDLIERLNMHRLLDRDLDELSGGELQRFCIFRTCMEKANSFFFDEPSSFLDVKQRIAISNVIREKRDYVFLVEHDLAIADLISDYGSVLYGKAGCYGIITKLFSIKQCINVFLSGYIPSENMKFRSEAMKFDRKEKMNVEEEKGVVLEERSDVLDLKNLSLRTNEFVYEAMEQKYENFVLNVRPGLFKSGEIVVLLGENGMGKSTFLNLVKGVFSVSIKYQKINLKYDKSVKSLIIRLKAINSVELMKDLEIDKIMDNDVCKLSGGELQRLCLFICLSKNADIYLIDEPSAYLDCDTRIRVSRLLKRFAVNKQKPLFIVEHDLVMATYLADKMILFEGEPAVSSVASEPLDVNLAMNTFLKGLDITFRRDPETNRPRINKWGSVKDKEQKEAQKYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTK0</accession>
    <name>L7JTK0_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2739"/>
    <dbReference type="HOGENOM" id="CLU_3020136_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTK0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6567" checksum="CBB4F5076449BA69" modified="2013-03-06" version="1">MSLSNVKFVDDNATQIFYSYKKVVMFVACKLRLLVLKNLLALNYSKICMNTEYLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTM5</accession>
    <name>L7JTM5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994042">
        <property type="protein sequence ID" value="ELQ74406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTM5"/>
    <dbReference type="STRING" id="72359.L7JTM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2672"/>
    <dbReference type="HOGENOM" id="CLU_683694_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTM5"/>
    <dbReference type="OMA" id="NDVCVED"/>
    <dbReference type="OrthoDB" id="10623085at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979015" evidence="2">
        <location>
            <begin position="23"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="390" mass="43441" checksum="C0E162B355F5BFCA" modified="2013-03-06" version="1">MFRNMSAMFIPLAFFTILLTTACNISSEASIEAASVKITDSNTSTTEKNKGEQEENQTTVSSEAHDEDKCSGFMTCDGTVGCNALSYADDDDDASSTGDMYVISYGNDELYKGDTEFDMDAFLNELEHFPFNKVVDKGLEKKNDEKQDVEKHDLQSQVEGETESNKNFESNNAPQKYFKSKAVQGHEEALIHEVVTKPEEQPENVVEKAQESESKEKNTTETNIKHEEAQESNDKHGVIAESKEAQPESEAKTVPEHDVKQTSEKETAADEEHKPTLEVNPATEPQEKQSDKQVTHNAESPASGSNNVVLPMPEIVDNNVEAKTADSKLVITPELTSRIVLGIYNSSEEMKKFGQRLEKKDKQYTEKAMTLLNTFLRGLEELEDEAQSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTR0</accession>
    <name>L7JTR0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2620"/>
    <dbReference type="HOGENOM" id="CLU_1887214_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTR0"/>
    <dbReference type="OrthoDB" id="10605753at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="135" mass="15655" checksum="6C6F1E4C995216DA" modified="2013-03-06" version="1">MVYRCYSTFKALEKAKSCSAIHESVTCPEDKILQEIDKKISETRSNTSIGYKVIILPISKQLYEKLSCSSWTSETKFSIDEMCDLLVMLPHFIEKGSLVAFLMFKNLLNDESLYLKLEKIFIAKSKHPKKIFFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU41</accession>
    <name>L7JU41_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase, LTR Retrotransposon</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="JH994020">
        <property type="protein sequence ID" value="ELQ74820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU41"/>
    <dbReference type="STRING" id="72359.L7JU41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2247"/>
    <dbReference type="HOGENOM" id="CLU_1526232_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU41"/>
    <dbReference type="OMA" id="DICWEYN"/>
    <dbReference type="OrthoDB" id="2194291at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="176" mass="20652" checksum="EF5490BC3FD8AE7C" modified="2013-03-06" version="1">MELKQQRSKNNCITKESNNNGYIGEECKINTQEGKMVKARPYNNTGPLKEKVEEEIQNMLKKGYIRPSDPEWCNPVRPVEKKNGTIRLCLNLMALNELVEKEVERMPEVDQVLEKLQGAKYFSVLDIKEGYFQINVREEDKKKTAFQIGSRKYEFNRMPMGFKNAPLIFQRIMNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU69</accession>
    <name>L7JU69_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2505"/>
    <dbReference type="HOGENOM" id="CLU_1200535_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU69"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031543">
        <property type="entry name" value="DUF5087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17006">
        <property type="entry name" value="DUF5087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="231" mass="27215" checksum="FB13A50D9C0F59B6" modified="2013-03-06" version="1">MVHTDDKIKKYENKIKSLTKKLKYKKIIIKSLLHTLQRKKYKKRKNGLEMKIENNLSVPIDSRADSVAEQVMEAEIEETGGDKKPDIDMIAAAHPESIATYSVLERNNRTKEDKSFRLNFKLDEYVEYTCSLFVPYVYDAKDDYKLSKLHLIYIKTNIKGILKHIFKDINTREVEKTWTLLFNLGCAQSYDALCMIVHDLFVFVDDFERVIYFSYALLHGKKLRLIFSQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU96</accession>
    <name>L7JU96_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone (DnaJ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ74994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2036"/>
    <dbReference type="HOGENOM" id="CLU_1490095_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU96"/>
    <dbReference type="OMA" id="RTFYEMF"/>
    <dbReference type="OrthoDB" id="2196113at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="21685" checksum="0E6CB57F794F94A5" modified="2013-03-06" version="1">MFPFLQTIRSLSNNTNILKSIQTLHKKTKFRTFYEMFDVKENTDIKIIRSKFYKLVKESKPFPDLNIPKGVAEKIITEGYNILNRHKQEYDALLRSKFSVPVSPETRTFFYVNLVVFVLFVALLSDLLVCLIRFLVNRRRYEGVDKAQEKKLRRRGDIEVFSLDRMYTIRFCKRLKRVFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUB4</accession>
    <name>L7JUB4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994046">
        <property type="protein sequence ID" value="ELQ74337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2745"/>
    <dbReference type="HOGENOM" id="CLU_2741837_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUB4"/>
    <dbReference type="OrthoDB" id="2189889at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="7838" checksum="AE2E97114D550526" modified="2013-03-06" version="1">MGSLAGAARLQDQNAAVRRHLQRDENTRVEHKGFRVLEHGLRGPCAGKPRPSDPTAARRIATWVTEKLPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUC4</accession>
    <name>L7JUC4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase II, subunit POLR2C/RPB3</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUC4"/>
    <dbReference type="STRING" id="72359.L7JUC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2710"/>
    <dbReference type="HOGENOM" id="CLU_1807584_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUC4"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase insert" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="15678" checksum="2294DCD54A17B84E" modified="2013-03-06" version="1">MLVHRLSLIPLPITTLKRKEECTCNVSCPACSVTFSLNAVSNEGMSVNASHLFSDAVDTTRLKGLICKMGEKQSVKMSALARTGTAKEHAKFCVVTVVRIGEDKIEFEVLDEVGKPVDVLVMALRVLKDKVARLIRAIEEYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUE6</accession>
    <name>L7JUE6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUE6"/>
    <dbReference type="STRING" id="72359.L7JUE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1937"/>
    <dbReference type="HOGENOM" id="CLU_524959_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUE6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052258">
        <property type="entry name" value="Diverse_Func_Domain-Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612">
        <property type="entry name" value="FIBROIN HEAVY CHAIN FIB-H LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612:SF20">
        <property type="entry name" value="PER-HEXAMER REPEAT PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="519" mass="54699" checksum="D8A23F99488FA35F" modified="2013-03-06" version="1">MAVNSAVAETASHDQPNGDTAVVTETAPHALTSSTISSLLKKCTAAACTYCKSAQTWCTGKLEGLLSRVLVKDQNKDATHAVNPRPTADEPSVNLQATTDQDDRPLTVPDASQVLVDTEQRSDSPASTNTTIDEEEFIPLSEDEDVQSYKSVGKEITEESIMPNDVYEMAEESIMPGDVDGVTEESLMPNDVDDALSVQSAECTEEIIPSSTVGNVHAVRRGVTGMRNARLILRENVVRSSSTRCMPDQTVTDRCAMGKCVFVGPKDVERPGHTSKAGVRSINAEDESNAMPWSPYQPLTAYQLRSNPVQSKNPLLQRIAVPLPLVEQLAELKTDDTSNLNVQVDLDHQLPLVTDGSVSAGHDNSNGNGNGGDGKNDEGTSDDSDGLIDDGNGEGDGNGEGDGNGEGDGNDEGDGNDEGDGNGEGDGNDEGDGNGSGNGSGSGGGGGRNRQMFRYAVSGGSGGGKKNGSNDTVVDPKKDQQVDNGTSQKNMSVAKKMFLLLLLLILIILTIIAFYYSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUH5</accession>
    <name>L7JUH5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative GTP-binding protein MMR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993986">
        <property type="protein sequence ID" value="ELQ75133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUH5"/>
    <dbReference type="STRING" id="72359.L7JUH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1918"/>
    <dbReference type="HOGENOM" id="CLU_866500_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUH5"/>
    <dbReference type="OMA" id="HISAVNN"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="180"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="321" mass="37820" checksum="BC8027EBA2E3511B" modified="2013-03-06" version="1">MKSVLTKEIIKRRFGEPVPLRSKKENFGSSINHQLHISAVNNFAAKNVANPCKHKSFPDPYISYIQFLAWQNNTVAEMNRNVWLQFWIATDVCDYICVVVDSRNVGFFFEEELLEMGKPVILIMNKYDLCNGNVPDDNNFFRNRFKFVDRIFKIFKFSNVDQHVNIEFLEFLKSQGNRKYAMIGYPNVGKSSLIKTISNHVKIKISSTPGKTKFVQSYQFTDILFLDVPGLVFKRHSREELLIYNIINVDQSKIDYEKLFELLLQKISMIQIIEHFKIKLLNTNCTLDELLAEIVKQRKWAKERFFRKLLKDFFEGKIMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUI3</accession>
    <name>L7JUI3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUI3"/>
    <dbReference type="STRING" id="72359.L7JUI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2395"/>
    <dbReference type="HOGENOM" id="CLU_880549_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUI3"/>
    <dbReference type="OMA" id="RFNNEYP"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="10">
        <location>
            <begin position="209"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="316" mass="36349" checksum="392ACCB09B23263A" modified="2013-03-06" version="1">MKSVINNNDSCSKRRKYDDCSDSVANYAAGVDENIIESVSENMNGNSCLDKIKGTLPRDNDALEAIEDIIDDSVANNGEAWHDDCTNNSGGKNDRKINFSRCAVVEKFSKNDSHEILMKKPFHSHWTSHMLRSSTIVKQQKKLALKRTFTVPTRRIDVTESSNFIDFWQRIDNGVKYTLPVVSHGKSDSIPRISCSVLHETITGKYNVKYKIIDCRFDYEYNGGHIKDAINIDNVDSLIRSIPSLCNHVLIFHCEFSSVRAPRIAKYLRNYDRFNNEYPSLDFPEIYVLEGGYKEFFHLFKDCCHPQNYVMMSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUQ2</accession>
    <name>L7JUQ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2322"/>
    <dbReference type="HOGENOM" id="CLU_1929075_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUQ2"/>
    <dbReference type="OMA" id="FWQRHKK"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979046" evidence="3">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="131" mass="14390" checksum="79A5B03C21F2748B" modified="2013-03-06" version="1">MRIIHSSLILMLAVVLDLFLVPVGAEVKVAPPKGEEKESEGEVAKPEEPEKEKEEPETEDETAPTGDKGSGDSGKSSGSVLGMFSSEPEKGEENKSFWQRHKKTIIWCLVIFLVIIIALAVVGFILKRRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUR5</accession>
    <name>L7JUR5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative N6-DNA-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="5"/>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUR5"/>
    <dbReference type="FunCoup" id="L7JUR5">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1879"/>
    <dbReference type="HOGENOM" id="CLU_018398_6_2_1"/>
    <dbReference type="InParanoid" id="L7JUR5"/>
    <dbReference type="OMA" id="CDAIQSN"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="175" mass="20043" checksum="CCB2A9158EF2DB34" modified="2013-03-06" version="1">MALFYQPSEDTYTLLDTIRAQELKNKVIVEIGTGSATIINTLLQYNHCIATDINPYALKNAKCDAIQSNLLDNLQQTGIDVIIFNPPYLNERIVRCEQMVPCEKCLDIYSYAGGQDGNEIIWQFLKTVRTKEFYLLVIRLNKIDLDSVPGYNVRVVRQKVILGETLYILHGVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUS8</accession>
    <name>L7JUS8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2004"/>
    <dbReference type="HOGENOM" id="CLU_2211806_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUS8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="107" mass="12631" checksum="12EA4C09A5E0B756" modified="2013-03-06" version="1">MTDKSYMVENPDTETITSETVNSGTSEPEKKMEMLELEMEIEGIGDEKEKVMFVLKNMDDKELKRFISMNGRSWCYDQLKKEIINKRVLEERKTERKDKKNTSKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV67</accession>
    <name>L7JV67_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV67"/>
    <dbReference type="FunCoup" id="L7JV67">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1705"/>
    <dbReference type="HOGENOM" id="CLU_000288_118_2_1"/>
    <dbReference type="InParanoid" id="L7JV67"/>
    <dbReference type="OMA" id="QGFTMEK"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060903">
        <property type="term" value="P:positive regulation of meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905263">
        <property type="term" value="P:positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905342">
        <property type="term" value="P:positive regulation of protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904968">
        <property type="term" value="P:positive regulation of spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="352" mass="40638" checksum="02D404756D5F59C9" modified="2013-03-06" version="1">MEEFSSEERTYFEWFADKYKVIARAGEGTFSTVYKAVDLNHTESDNSYSNAAIKNITMTSAPARVAEELRFLKKLNGENGVIPLLNVLRFEDQVVAVFPYFECSDFREFLEFCTIGDIKVYLRQLIIALKHTHDNHIIHRDIKPSNFLYNSEQQRGFLIDFGLAQEEKSVQAPDTTPARNAKTKPSVMFFNSVVSRSTQPPGYYQTDTRPVMKAQRAGTRGFRAPEVLFRNQNQTISIDIWSVGVIFLILLTKQYPFFNSLDDLDALVEIACIFGNNEMRKLAKYHGRVWKTNLSSIPNERIPFERIVRELNPSCCLDKHGYDLLYRMLELYPEKRITAEEALAHPFLQNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV86</accession>
    <name>L7JV86_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin complex component, TCP-1 eta subunit (CCT7)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV86"/>
    <dbReference type="STRING" id="72359.L7JV86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1696"/>
    <dbReference type="HOGENOM" id="CLU_008891_2_0_1"/>
    <dbReference type="InParanoid" id="L7JV86"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="230" mass="25550" checksum="A0191093D53D5A21" modified="2013-03-06" version="1">MEEIQVNTIEAQDTREGIPQVLSNIDSWNAIADSLKTTLGPYGRDKMFLINDEILITNDGATILKNMKIEHPAGRLLAAISESQDKEVGDGTTSVVLLACGILEHLKPLVKDSLDIKFMKNTLQEIQEKCLKKLEDCKIGFNDDLFYSIAQTSLTSKILKYDKCSFAKMIVDTLKGIEDIDDTRLIGIKKVSGGSISDSEMVDGVAFEKCFTYAGYEQQPKKLQILKYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVC8</accession>
    <name>L7JVC8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2048"/>
    <dbReference type="HOGENOM" id="CLU_1078475_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVC8"/>
    <dbReference type="OMA" id="TADNYKI"/>
    <dbReference type="OrthoDB" id="10365857at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="258" mass="30011" checksum="C643FFB6524F05FB" modified="2013-03-06" version="1">MISTHHDNIYVLNNNLLLIYNLDLNLTRTQKVMAVYTPILHKNYVAVYKTLYKISNGDLVAVRIFRKKIIGLQTDEEYIVVSESTGNVLIARRAEHRFQPLLGHYLQLNKLLIHDSAVITADNYKIRVSEYDGRIRNIFFVDNQNVFYNGGYFYVVYENNLLVYDKKERMDREKCEIGCDTLVLLNKITIDNEVKDVLLLEGAVYLITDKNNYLVRDSACRLGAPSPYNFKDAVIDDDSVYFYTEESKLQKINVKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVJ1</accession>
    <name>L7JVJ1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVJ1"/>
    <dbReference type="FunCoup" id="L7JVJ1">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1543"/>
    <dbReference type="HOGENOM" id="CLU_132771_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVJ1"/>
    <dbReference type="OMA" id="FILCECD"/>
    <dbReference type="OrthoDB" id="74210at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034752">
        <property type="entry name" value="Mis18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51793">
        <property type="entry name" value="MIS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mis18" evidence="4">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="125" mass="14528" checksum="FDBCE787BA57073A" modified="2013-03-06" version="1">MESDDALQYPFILQCAHCKTIIADSFSLIDYVQNTLTLTKVSSFVKFKEKECPNERPYAFILCECDTVVGKKYRDESVYLLDDTQLISYVLGNGNSKRYSINEVVEELGKLQKFCLYLYNRLDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVS6</accession>
    <name>L7JVS6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2207"/>
    <dbReference type="HOGENOM" id="CLU_3020139_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVS6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6426" checksum="6202C94238563CF5" modified="2013-03-06" version="1" fragment="single">VLRSNELRLEVFVDGDRLIRENAGYLDAPVNPRCVPQSNITVFPFIFTIIHERPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVT2</accession>
    <name>L7JVT2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1451"/>
    <dbReference type="HOGENOM" id="CLU_1518999_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVT2"/>
    <dbReference type="OMA" id="NNRDYTH"/>
    <dbReference type="OrthoDB" id="2192066at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="21923" checksum="B45725E0ED63AAD6" modified="2013-03-06" version="1">MFAEYRIIFEYKNKLYSKIMNYKKVSTYVFLSLSLIVFIGAIILLIMSCRTEQIIEQGQTRTFYRAKSNKIDLGMTKEDFYTETSTLILFNVSKDTFIFVYNENQIKILSRDELEELSDEFLRKRVSPFGEMLLKYIELSRIIFLPILKFEKTMGKLIINNRDYTHDLASYCNFCMSCLAKSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVZ3</accession>
    <name>L7JVZ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Nucleotide-binding, alpha-beta plait, RNA recognition motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1524"/>
    <dbReference type="HOGENOM" id="CLU_2127099_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVZ3"/>
    <dbReference type="OrthoDB" id="2196320at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="114" mass="13415" checksum="971C6851229EF0CE" modified="2013-03-06" version="1" fragment="single">MLAFTKMFRTLQNELLYNNRTVYIKFIKHNYRIFISGLKKTLTKELVIDYLSDKGYGVTDVLVPVGGDVKNRGYCFVQFDGESGVKRFKDEYRKYKGFFGTASRIEYAKRDEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVZ4</accession>
    <name>L7JVZ4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_1462</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVZ4"/>
    <dbReference type="STRING" id="72359.L7JVZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1462"/>
    <dbReference type="HOGENOM" id="CLU_1318217_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVZ4"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ75599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="23871" checksum="6F1BE62CAFCE32C5" modified="2013-03-06" version="1" fragment="single">VIVNFVVVQYLAVHDLGIEKIEISDDGKYVVAVSRDKSVSFYRILDTSTDSPAGKDSTHNNGNNTTRFNESDAENVINKILNDSPYYLSLRKRIFSHSRRVNAASFDNLGTMFATGSKDRNVLIYSVDSLDVIETIKCEEEVTALRFHDRHLFVGLKNGMLKILKTEGYNQIYEQRIHAKSINEIKFNNNRLITISDDNMMRVFNINKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW11</accession>
    <name>L7JW11_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1834"/>
    <dbReference type="HOGENOM" id="CLU_912723_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW11"/>
    <dbReference type="OMA" id="NIMAWYL"/>
    <dbReference type="OrthoDB" id="10408476at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="305" mass="36151" checksum="AAE155E375F7749B" modified="2013-03-06" version="1">MNTLFILNGIIPICFVCILSLVADLLNIFIGNIMAWYLIEKNWYITCSYDITKFIRHVSIDGNKITIVDQFNNKETVESEVIDETFKRFPFYNIEYRESIQALLFFRNAPCLFPDEVIFLKNKLPNINKLGFEEFTKIVIKEKHSIDDITSFSTLFGFFVYGFLDGFEIQIYKNCILVLMEGKYFFCIQIEDCCRYFGTISVEWSYPILLKIYQSSFKIVIGKTIYVGQVYDEIVNVKARKYWFNKRLSCTELEKIFASLDLESPQMHLPKAETNYLSLYTSKQEKVKEYKRVYHKNFKEMYRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW51</accession>
    <name>L7JW51_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1762"/>
    <dbReference type="HOGENOM" id="CLU_687327_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW51"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="401" mass="46171" checksum="979B8979990F366B" modified="2013-03-06" version="1">MQSTEHRTVLQILESIKQNENEGVPSDVKYLKILHEIIESELNDEILVQHETVMHEEREMNRHANISLTNEDTSENLDGKENCAGNKIDLKDTTKKKIAVTYKKQITQWLLILLNNPFNLSFVNTSAFISFIVEDPQCTALLISNLMKNSENVQFYREKEILNNKVSDAKYYEFLYHLSKKVRLYEFCDKSAEQPSYTAVQGHDKECADINSSLKQKLSLFIKPYDTEVLKALKYKIITNQGIYGHIEKQLVLDTLFSYLKRSSSIHSFALSYSISKFNFDIDELLMCFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTLDRTLNTTLNTTLNTTLNGTLNRTCDDRNENEEKYKKNLSCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW73</accession>
    <name>L7JW73_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_1380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW73"/>
    <dbReference type="FunCoup" id="L7JW73">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1380"/>
    <dbReference type="HOGENOM" id="CLU_000995_3_2_1"/>
    <dbReference type="InParanoid" id="L7JW73"/>
    <dbReference type="OMA" id="KQVPAIY"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="240"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ75708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="707" mass="80612" checksum="D0A1B11ECB87F1D6" modified="2013-03-06" version="1">MSKYNASNYEEALKTYLQTNPTHPISLKTLSMHDKDLAYFIINNISQLNKKYKFNDNLVIYKLREICTRQMNCLVSFRARVTRTTAIYPELLSAKLRCESCKAVTRESTHYHSFRCVNHLCANRKNYSVLPVRFRDYQRISVQEVDADIVGGYLPRSLEIVVLDDLTEKVKPGELVVFNGVVRIERNARLKKVLKRTESVISAEEDHLKIVFEAMSIEKDSKHVLDTHKVLRKIGNVPNVYETLSHALFPSIYGHKNIKNAILLMMVGGCSTKRTNINILLLGDPGTAKSQFLKQVPAIYTTGKTASGVGLTAAVTKNENENVVEAGALVLADNGICCIDEFDKLSVADRTALHEAMEQQTVTINKAGIHVTLNARASVLAAANPRGGRYDRKKSLRYNVSLSDAVMSRFDLFYVIVDEVDESNDRRIARRVINNHLGFDEYDVGGKKDGDNDVDKEILRNVGRESLPEVEGKDSGKEGLRDLEGKESLREGLRDVDDNDRATADDKIKEDLKAIEQAYNKELNITKEEILVYIQHVKNRRPSMTDEAHKLIVEKYKKLRMQNTVNHKNYTVGVRTLESMIRLSEALAKLHGTDVLCMYVEEAYRLITGSMLEIKMEDVQIKDTIVNSKDVESILNTFVYILKTKERLTREDLVMYYISSVEDKIMSEEMLEEEHRQAENVLEWLINKEGVFYENEGYVYVHPNYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW82</accession>
    <name>L7JW82_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1331"/>
    <dbReference type="HOGENOM" id="CLU_938641_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW82"/>
    <dbReference type="OMA" id="HRHVDGK"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="297" mass="32974" checksum="60320DCC1ED830BB" modified="2013-03-06" version="1" fragment="single">VLLNTSFIVIKTSSLHYKNKSKKNFRSAMADKNMKDNVNDNYKQDDKKKQVVDGTKQTYGSAKDKGAQMAGAAGEKGEHLKEKTGGMKENAQEKTGXXXXXXXXXXXXXXXXXXXLKEKSGNVVDTMKDKYGTAKKKAGELADSAKQKYEDTRKKTADTSGDDKQKGGDMKGKGNQAINKVKEVGEKTKYKTEKAAATAKEKAAGMKGSARQATEKTKEAGRETKNKAKGGADKMTGGDADAEDEVKQVVECPKEDYEKIKKKMEQKLTSNHFKDERFKHHNPFYYNYGKKNDEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW83</accession>
    <name>L7JW83_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW83"/>
    <dbReference type="STRING" id="72359.L7JW83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2060"/>
    <dbReference type="HOGENOM" id="CLU_028780_1_1_1"/>
    <dbReference type="InParanoid" id="L7JW83"/>
    <dbReference type="OMA" id="ICRIENP"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="5">
        <location>
            <begin position="70"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="322" mass="37167" checksum="9FC410220D69B5A3" modified="2013-03-06" version="1">MDHSIIATVQDKLKLIETYDTIVINTIREYKEHLRDAFPGFIINPGKRIEQSTEVFVTENSCKVVNHSLFIYGIYIKKCRNVSQTPMPNVENAVSDIFQNFEKFYAADSSNFVAAGREDVDVINISGRPFFVELKNPKKNLFTPIPIAYRENDFVLLKNLLRVKGTLIKKIILDGEREHKKVYNAVVFCSKPKDPTNIFNFEHDDGYEAETENVLQAKELEELVNKKLSIMQKTPLRVLHRRTNIIRPKEITITKIEKFQQYLQLTIQSSAGTYIKEFITGDFGRTVPSLASLLRCWCDCLELDVLEVETKEVPKNCIYESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWA5</accession>
    <name>L7JWA5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWA5"/>
    <dbReference type="FunCoup" id="L7JWA5">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1356"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="L7JWA5"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002469">
        <property type="entry name" value="Cell division control protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="6">
        <location>
            <begin position="251"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="639" mass="71441" checksum="4B997F84B4EE676D" modified="2013-03-06" version="1">MTYQDNTVTSADLLSGDVPLNKEEIKKQFQAFLSSFSINNQYIYRNRKTVQLAHLAVFDQVLYNKFLAKPREFVDLVDGYEFISEKSFDLIRNLDASKTNKIVRVRGIVTSVSNVHAKPLTLYLTCKSCFVVKEVTDVIPRSCQNGCMFEPFIIVPEKSKVVDTQSLKVQEDFDDVPSNEIPRHCTAIINNALCSNELVPGSNIVFTGILLVKSSKTGSVPFIRIIGIEKDVAKQKSFTEEEIHRFKSFRFFDNLQKIIAPNIAGHDDVKKAIACLLFGGTRRVKNGVALRGDINVLLLGDPGVAKSQMLKFTSQIAPISVYTSGKGSSAAGLTASVIRNSMREYTLEGGALVLSDMGVCCIDEFDKMDEFDRVAIHEAMEQQTVSIAKAGITTVLNTRTAVLAAANPKFGRYDDLKAPAENIEFGSTILSRFDCIFILKDEKRMDRDIALAKHILDVNTNVSIDDTLYDAEFIKRYVTYAKSISPEMDAQAKQRIKNFYIKTRQAVHSHSKKEFSIPITVRQLEAVIRISEAFARMSLNTRVLPEHVDEAIHLFRVSTMNAVNDGHYLDGMLRSDVISKVRTMADRILKVLGVGNARSIAALAEHFGERDIVGQAVTYLVRKDKLALRDRGRVVIRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWE0</accession>
    <name>L7JWE0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcriptional repressor EZH1</fullName>
            <ecNumber evidence="11">2.1.1.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.43" evidence="11"/>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWE0"/>
    <dbReference type="STRING" id="72359.L7JWE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1663"/>
    <dbReference type="HOGENOM" id="CLU_030443_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWE0"/>
    <dbReference type="OMA" id="CTKETID"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046976">
        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="10">
        <location>
            <begin position="270"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="AWS" evidence="9">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="367"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="502" mass="58494" checksum="DEAEAF3DC6C032EB" modified="2013-03-06" version="1" fragment="single">VFVEKGPVHLEEFSNQKFMKVVIPQIEPQPPYRYFVSSRINISGTDDPVLRFVPFINSEENYTTITNYDDTLLTEKPLTQEEAIKNMALKKVFSKFSDATLYRLKCNIADGKINEVKDTREYITLQNVAQHLKTRVIKLLEKWEKDFDRNARPLYIDQDSFNAYFCNVCLIFDCNVHGAYTKRMPRSANEEPPSKCSDECYQSIATPEAIKNAQNDTPVLTNKYLYVYQKIRKNFNFNCCELTRAFNFFSSLNLSCKSIFLLSEKNKINQRKLTYKEKTTAAPSNYNIKYFELHSPCDHPGSCQKNKNCTCYTNKIFCEESCFCVKCDLVFTGCKCRKCGKSCPCRKYSRECTDECKCTRCMNNDLQNMKERPTYVAPSTVDGYGLFTVDDLSKDDFVIEYVGEIITNEEAERRGLFYEKRKLSYLFDLSNLSDCTKETIDATKIANKARFINHSKKANLIAKTVQVAGRKRIGFYAQKTIRRNEELFFDYRYKDEQKKITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWJ8</accession>
    <name>L7JWJ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase-like transcription factor HLTF/DNA helicase RAD5, DEAD-box superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993914">
        <property type="protein sequence ID" value="ELQ75853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWJ8"/>
    <dbReference type="STRING" id="72359.L7JWJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1189"/>
    <dbReference type="HOGENOM" id="CLU_2428621_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWJ8"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="91" mass="10686" checksum="EF85FCFF8A72B50A" modified="2013-03-06" version="1">MTKRLKLYNWFKSRAFESFTEGVKTGQLMRQYTQILTHILRLRQVCCHVDLIGGAHEMDDDVIDLEVDEEMKTFLKTIRIKVVASLLMIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWN2</accession>
    <name>L7JWN2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-related small GTPase, Rho type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1206"/>
    <dbReference type="HOGENOM" id="CLU_1497255_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWN2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="180" mass="21718" checksum="4B2F803D6CC600A5" modified="2013-03-06" version="1">MNRIKPYEFDKFVPLKHDEEATDLQNDYLQNIFTDVHSECVFLFSKSMTGRISFEYLSQEWWLELKHNKENLESFLVNNNRYFTAEHRSKLYVYSHSVHNYFEYIPNLYNKAVWGYVKHNVMIISYNQFLVNLFDFLNCLCVRNDLTVEIVDDKFEQLDEQISILNNNLKKMKDIISKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWP8</accession>
    <name>L7JWP8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulator of arginine metabolism, MADS box-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993913">
        <property type="protein sequence ID" value="ELQ75854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWP8"/>
    <dbReference type="STRING" id="72359.L7JWP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1181"/>
    <dbReference type="HOGENOM" id="CLU_095427_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWP8"/>
    <dbReference type="OMA" id="YNTYHEP"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="255" mass="30438" checksum="0C18D4BEDB752EF8" modified="2013-03-06" version="1">MNERKKRYSDEHEEEIVYTNENGVSDYQYQNESMPSSYQYYQSMRYDDRFPNSYQDDYNYRYNTYHEPPRHFDPRYEPRNMHYNQEYGQPAYERPAGMTAHEFPKTRIEEENMEIEHVAKKKATKSGRKKIKMAYIEGKNKRSVTFSKRKKGIMKKAYELNMLTKSQILLLVASESGHVYTFATPKLKPIISKHENLIQQCLNAPSTPDKSKFIPDMDENGTIHDSERHPYVNRQDYYDGGYDSNGRDYDMSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWV5</accession>
    <name>L7JWV5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular protein SEL-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWV5"/>
    <dbReference type="STRING" id="72359.L7JWV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1067"/>
    <dbReference type="HOGENOM" id="CLU_000288_36_14_1"/>
    <dbReference type="InParanoid" id="L7JWV5"/>
    <dbReference type="OMA" id="QNCLAFF"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="585" mass="66786" checksum="B702A8F1CBD52DBC" modified="2013-03-06" version="1">MFSLISRNKFSEFERLFFGIDRDVDESAAVQILEKEAKENYESLAILSFCYEFGIGVHRNIKKAEYGYMISSSKNSGLALVRLTFLRKFGRPNVRIDRLEAQILQNKLRAIGSASVAWLEKAAKLGNSYAQYCLGTCYHDALGVRRCTKRSIEWYTRSAAQHNPCAIGVLGFCYLEGFGVEKDEYRAFVLYLQAARMNDPVATYNMGFCYEEGKGTDKNIKYAFLWYKRAAEMGNPFAQNSLGYCYEEGLGTEKDEDKAFALYRASALQGYPWAQSNLAYCFQQGIGVQKDLKKSFEWYERAAIQGLSRAQHNLGHCYHQGMGTDKNVTEAVMWYRRAAKQKNLYAFHSLGNCYQNGEGVPKDEREAVRFYKLAALKNFVPSLISLSFCYRLGLGVDTNALSSFYYMKKAAELRNAYAQNCLAFFYEEGYGTKRNINLAIMWYTKSASANNPWAQTNLGTIYFEGIHVPMDREKAVYYFKLAANQGHSRAYSKLGYCYEEGIVVHKNPSIAFSYYSKAAEQGYNRAYYALGKCYERGFGISVNMNQALSYFYKGSFYGDLRAREKMKKILGRCLINECKMFAKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWV9</accession>
    <name>L7JWV9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWV9"/>
    <dbReference type="STRING" id="72359.L7JWV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1825"/>
    <dbReference type="HOGENOM" id="CLU_455344_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWV9"/>
    <dbReference type="OMA" id="KNNETMG"/>
    <dbReference type="OrthoDB" id="2191694at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="600" mass="70920" checksum="5FEABF12FF4A01EF" modified="2013-03-06" version="1" fragment="single">VVKYEQRALYNYQDYITSVLSFLCNILTETKNYVFLELEDLNEITIAIARICEYKKNDLSLSKLFTGLYASSYDIIDKYNKIWAHLEEDLLCLTVNLQLTRILYRVTYHQGLRAFDYNQFYNNIINLKYGKPVNLSMKKYKRVLNTFYTNKYKLLDIVYDNQPFNTEMLVKDISGCSDCYGVLRSLKKLTLKLKLDQLIRVGIIGIETCKNAGYELKSGDLSATTNEQQNTKHVRNGCVKDEGRNKQEPVDNNVLLCNKEKDKDFNSHKMTNQKRNVDVMDRNETKKNNKDLESMLNTETMNDRQMWNNSSLDGKNYVFLIKFALKRCFIDQKMFEKNVELYKMFLVNKGPALILIATSAFTENMKDLKYTGDHLDLLSFILVLNINNRNNRIVRRKEQIIINVFSALKTDDKTAFVKYFFENLEKLKCYEFNPFFVSFILTFNKEIKKTKNTFVKYVINALEWNENTKTRFLEMNKSRNDNDGIFTETYTKIYVSLVCYVCVKYKLKITDHMKSYYGVIIMLINCIELSTDNNYQNILKTNILEIVFDLSEEQRNDVKALYYIFLKDKCKFESAYLCFYKNFSKRINKRIKQNADKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWZ4</accession>
    <name>L7JWZ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993979">
        <property type="protein sequence ID" value="ELQ75247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1810"/>
    <dbReference type="HOGENOM" id="CLU_1346102_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWZ4"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="204" mass="23892" checksum="462F639FD1CBBC66" modified="2013-03-06" version="1" fragment="single">VTDIFIRNPFLYSISFDRKLKVWNLKDERCVFKVTLDVVPLKIYIETDDFDCSSTAELNQNEINSGKDLHHIAADKDDDTVRHTKKQRIGDTYGSHKRKKTQMSNHKEICWSKNINRIIIGTSKGLSVFDCKFEELKSILIGFVLDIQSNAQFYFVLASSRKLYILEKTSFEICDEYCDVDCFSIFGTNSIWGMLNKYQFMIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX38</accession>
    <name>L7JX38_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear receptor coregulator SMRT/SMRTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX38"/>
    <dbReference type="STRING" id="72359.L7JX38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1427"/>
    <dbReference type="HOGENOM" id="CLU_028831_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX38"/>
    <dbReference type="OMA" id="VMIDLEW"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="326"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="639" mass="74361" checksum="27F2CCC67363E50E" modified="2013-03-06" version="1">MHIHNDTCQDQCIRPGRVLPHSPQNKKKDLIKLTNLYPHPPPNKLTIIDRTTENLGRPTAKKHRQQFYTTAPTKTTRHPHIIVTHRNNHQQTVQHGKSCRNCLFPATSEMLFITAQQEEFLSLPKKLGRIKKMIEKQNFINTEISQYPQMSGNKKLCKSVLEINKDTYIFKVMQDDKVVKEYMLSAGAFDEFVRDKRVDVGGEDALKYLDGLVKQRERMETVVDEDSVVKLKNVFGDEHAQSGENNADGHSPAKERATGDRPHINDEIARAWLSLTHRKEYTANEYYKFKLSNEIADMERYLKNKADILNERVLYVDSKKVASTHVPEEQWSAEEHAQFLEYFALFNKKFHVIAKLLGRNTQDVIQHYYCTKKRERYNKRKNGRLSDSNLKVMIDLEWTESERSKFERLYDFYGKNWKAYEGSFMGKGVSDFKNYHRYLSKNKDEEKECKTSCTKSVDEGTESVAVCDSGDKESVVHADEHIEDVQPCKGRRKAGRTAKSAASRRQPKVPARRGRKKSPATKRRLNYSTVKRPKNDKENNTNTKQNVLEDWTIDERQLFAIFYPYIGKNWSDLSQYITTKKPGDCRTYFKFYFKNLSLAEQKLEAAMRNIERSTLSVPGSPRRLNDDDLIDDVGIIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXA0</accession>
    <name>L7JXA0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0969"/>
    <dbReference type="HOGENOM" id="CLU_1125201_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXA0"/>
    <dbReference type="OMA" id="VICHYTE"/>
    <dbReference type="OrthoDB" id="10506456at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="247" mass="29644" checksum="88F1A79E686E38E5" modified="2013-03-06" version="1">MIAMYFQKYLNDVNYHSMYKTASMKLIWSFIFLVLFYISCYLLWSYCTIVKINKMFIQKVNKSYEKFQSTWKTSKNGDRKFLILLYKKGIDKYVGFTAANKEKLANFRGKVGSKYETNLSAAQSYKAELAALHEQMPRWITRWFRTPWNKYVDTMDVICHYTEKTCFQKNDNYYYFYCIHGERGKILLTQVTHWGKGKKKTRKQILNRIIDYGDFVDDFADRALFYLFLQLLFRNPPRKIAASMKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXB9</accession>
    <name>L7JXB9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993878">
        <property type="protein sequence ID" value="ELQ76079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0955"/>
    <dbReference type="HOGENOM" id="CLU_1778870_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXB9"/>
    <dbReference type="OMA" id="CNDHRAT"/>
    <dbReference type="OrthoDB" id="10502424at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="169" mass="19426" checksum="BE246E463C590200" modified="2013-03-06" version="1" fragment="single">VINYELQWYKYKIISFPYVGGKKLIAFYESLATNKLMKPAGTNKKCNNIKKLIDLFDGQAMANIKGMVAYDNYKANKIVVAAVDERTKKIEAQIVVQPDQQAIEIECCNVLDKKNKSLEHTKITSGKVMMVEEIACNDHRATKKTTKKRVSFEMTCNKVYVYKKIEWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXF0</accession>
    <name>L7JXF0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1378"/>
    <dbReference type="HOGENOM" id="CLU_2723994_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXF0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="72" mass="8266" checksum="74529BBBFAC50101" modified="2013-03-06" version="1">MLILNCHISILSYIYVRMISSDKVFLLNCCPDALHHITEIQVKPDLIANSIERAMNYSGPQEQQPFKGRFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXH4</accession>
    <name>L7JXH4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1018"/>
    <dbReference type="HOGENOM" id="CLU_2514226_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXH4"/>
    <dbReference type="OMA" id="WKCIRNT"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="10334" checksum="F28056881D02F42D" modified="2013-03-06" version="1">MRPKRNATTKRRHATTPTDPRFFAKCNVFRHLQNYAFLYPDEVNDKVKNMKRRRELEDFLVKKGKKKYFVNGGEKELWKCIRNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXJ0</accession>
    <name>L7JXJ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993954">
        <property type="protein sequence ID" value="ELQ75472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1576"/>
    <dbReference type="HOGENOM" id="CLU_1327277_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXJ0"/>
    <dbReference type="OMA" id="GLEECTH"/>
    <dbReference type="OrthoDB" id="2186204at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979107" evidence="1">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="219" mass="25307" checksum="84FFD7254ECE229F" modified="2013-03-06" version="1">MLRFCLFVLFCFSSYREINPFMKASDDVHQIFLIGNKGYEKESFTLTIFDTDNDRDTFFPVGLSKVSEKTLPFQLFNSNFESQGLNFYLTWNGDKNIYVVPEGDYLQARKGSVDIRTGMTMHSILSPSSSDQQNNSSLFVKIMYGGKCLEALKWKSKYRNAYPLKFLRCSNSEYQVFKLINVIKAICHVSSEKCMYKNEDSFRATEALRAKLHRFAIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXL8</accession>
    <name>L7JXL8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative PAP2 domain protein</fullName>
            <ecNumber evidence="3">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="3"/>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1257"/>
    <dbReference type="HOGENOM" id="CLU_1497330_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXL8"/>
    <dbReference type="OMA" id="REKRPYW"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01610">
        <property type="entry name" value="PAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="180" mass="20786" checksum="EC31129C21CE45AD" modified="2013-03-06" version="1">MSKKCFLFTTFILSIILYTTIHFLPIRIVTNTTTRPSTYPSQLLMLSVYITPIGVFAWQIYRNKYTSTVFLVYYAGLFITETLTHVIKLCVREKRPYWQQERRGMESFPSGHSSDMFYMATMFMNESIVCTSAFYVWAVVVGTTRVIDGKHFVWDVVGGALLGLMVGWGMKRVFGSLYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXM1</accession>
    <name>L7JXM1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0856"/>
    <dbReference type="HOGENOM" id="CLU_3193991_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXM1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5067" checksum="EC449A6AFD1AED98" modified="2013-03-06" version="1" fragment="single">VLKMLEKLKSCITDIISRMSSIYGKIKGRLVGRILSVTNSLTGDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXP2</accession>
    <name>L7JXP2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993951">
        <property type="protein sequence ID" value="ELQ75527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1518"/>
    <dbReference type="HOGENOM" id="CLU_215608_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXP2"/>
    <dbReference type="OrthoDB" id="2194712at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4104" checksum="27333D67709EAC15" modified="2013-03-06" version="1" fragment="single">VEKGEIIAPSKGDSYLIRRSDGRILKKRHYELKSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXY4</accession>
    <name>L7JXY4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0734"/>
    <dbReference type="HOGENOM" id="CLU_552292_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXY4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="494" mass="56791" checksum="93F671532F0FDF18" modified="2013-03-06" version="1">MFLFVRGIFHSLVSLVTNRNESSLPSSDFVMVDMPNNLPADQSYSGYFGADSESMDIPNEFDVECEAQVDNYATAHTSVESINDSQPTSNHTQPEQVETMKQQASESLHTTDNVLKDCYDSYPSGYTDSQPRSLIDEPEHDSGPRALTLEGHEWLLLDDSKQKCKQEYQNTEPTNLNVNELCKTKFHTWPYFKDNSVFNIQTVCQLDNCYFQNSAKNSLFFFMTIPRLKLLLEQPCFMTMSKANQILEWIWSNGAARMNWTGSFFEVFDQVYEDAYKQRSVNATVFMVRKLLALLRNDMLDSFANPVYYVFLNQTCLMRLDATKRTDYSAECSGDWRIEIEVQPKESTLMKSLIAMGVIDPFSVDYTDVCQRGHISKCDVNGNSQICFLQSPILFITLDHTMNSIHQDTDEENNRLPSRFEVDKELDFCTFSYKLRSFIHLTDAQPGFSSVYFVDDAGDWWCTMNGNVTTVLDINKILSDGLKIQILCYERQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY42</accession>
    <name>L7JY42_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0666"/>
    <dbReference type="HOGENOM" id="CLU_2943458_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY42"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="6747" checksum="9D836D93C9CEB772" modified="2013-03-06" version="1">MPPLPPPITIRSYIRHGHPAALIFFGDQSHRRTTTNSYAKDVCGTDQLQVKCAAVQLLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY48</accession>
    <name>L7JY48_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome regulatory complex, subunit RPN2/PSMD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993891">
        <property type="protein sequence ID" value="ELQ75986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY48"/>
    <dbReference type="FunCoup" id="L7JY48">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1046"/>
    <dbReference type="HOGENOM" id="CLU_019837_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY48"/>
    <dbReference type="OMA" id="INYYNIC"/>
    <dbReference type="OrthoDB" id="2196194at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="934" mass="106997" checksum="926EA37C0836016F" modified="2013-03-06" version="1">MTHHKKHMDVLSILPNIEYNLKKSIDLAATLNTIAGNIEVLAPHINIKLLHDIHERVAANSDTTGISILLSKIYFIRDDYRNSIAYFNGRHKENSFYYHFMHIKLIDTYLNDRDTLSAELVAYVEDILKEENNMGIIMETRRYEMIKEVKDESTLEFLKGMMEIEEFHRLVLKLDLRNEYRYFIDALVYTELMKCTERNDTTEKEEGHVKCTIKHERSTPTEEEAERHGVRYISYSDVEGAKFSCRAAVHAVEAYIASLPLKTQFAASYYVSEVFPQVAVHVNNEHTTEVLNGNFRRMLVKDFLQRNNRTNFSIFSSIAKGIKKNIKALNLPLIFTNTFLNLCTGNDTFYRRNENFFRGLKGWNKYIGIECFGLIHMFSNDDTDTSSEGEPHPEEAAYKNNEDEEGRTGRDRLKLIEILQDLLPSSIKSGAITFDNVNSTESAALHALGLAGKETDFIFNFLDTENFFGSTLGMGNAYFATRNAMLTLKFLENLKREELHFECFAYAIGQINAKSMDLKLLTELESIIRFSEHNRIAYSSAVAMALIVLNDRSYPMYNAQELRSFDFYNPENAATRDIKEHVERIRECAKRMLRTEYRENTALENLVGYVLCLTKNQNAYLRLAGTLCLGTFFVKTGNVAVIDSLLNMVKDNSEDVRRAAILSLGLVVRDENIVSILNFKVLSHCPFVRAAVALTIGLFLCASGDSEAVDVLETLLYDSNPLVVQNACIGLGLLLMQCNSCVSNFKRIVNKVDLIILRSGDNSAKFGALIFRGLINLGGTNLILSYKNSENRINYYNICNYILFYGFNYFYMLIIYLGLCYQPTAFFKVNVNAANKNMKEYRNMKYKLVGKILVEANKKLGMVEDVPLPKRKVKKFRRRGNEQTEPCTCADKEEDKESGKKQAYYVKSGGRITLREMLKTRKKDFAVEFTDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY71</accession>
    <name>L7JY71_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1339"/>
    <dbReference type="HOGENOM" id="CLU_2741836_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY71"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8150" checksum="A7ADEA8340C43C15" modified="2013-03-06" version="1">MADKTNVQSIVEGINKREENREKEKKVAYSYVSTENVSRLAFVFDKNSSCGRVRRIKEKLGLDVDEGDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY88</accession>
    <name>L7JY88_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0719"/>
    <dbReference type="HOGENOM" id="CLU_2656203_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY88"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8653" checksum="4C6844D17294077D" modified="2013-03-06" version="1">MELMVILLHRMELMIVVLDRIVPGRLVLYRLAAIVVVLDRLMLNELVLDRVVPDRLAAIVIVLGRVVLSRNKPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY94</accession>
    <name>L7JY94_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1364"/>
    <dbReference type="HOGENOM" id="CLU_1125204_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY94"/>
    <dbReference type="OMA" id="VERAKMY"/>
    <dbReference type="OrthoDB" id="2188797at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978876" evidence="1">
        <location>
            <begin position="17"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="247" mass="28573" checksum="725D7712E7B94BAC" modified="2013-03-06" version="1">MLFAGLILLGSIYTQATPIYTYDASRGHPPMYTQADPQTGCYYTNTQNGLVQVCPKPANQPPTSLPTREVIASFPVVKRVVKTTSKVASPKESPLDSLMQTNPELGEQIKKIFAYQGITEPWDRIKDFFDNRQRLMPDPCMLYKTMRDILKVFESLKEMISDELRKIQVYVERAKMYLKEDHVKLKDLLSRMSLDLVKMKSTKDKKNQNDYANNFNKINAETQQVIASYNQLKGWLFKTLTYFKQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYC8</accession>
    <name>L7JYC8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993931">
        <property type="protein sequence ID" value="ELQ75732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1311"/>
    <dbReference type="HOGENOM" id="CLU_2470664_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYC8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="88" mass="10156" checksum="936E52373A64F57B" modified="2013-03-06" version="1">MFELAAETTYLGDELLKSKKTIVRSAKWSLSFKLYVECMLNNVLSCDTGTIISNFVKGIDMMNSEKFIFVLNNNLAHELILNIFNFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYD7</accession>
    <name>L7JYD7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mismatch repair ATPase MSH4 (MutS family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993929">
        <property type="protein sequence ID" value="ELQ75742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYD7"/>
    <dbReference type="STRING" id="72359.L7JYD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1300"/>
    <dbReference type="HOGENOM" id="CLU_1023730_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYD7"/>
    <dbReference type="OMA" id="ERCINKQ"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="272" mass="30951" checksum="3F883459E3118018" modified="2013-03-06" version="1">MCDAVAEIDLIISFVNFSKNRICCFPRFTDKFVVANTYNLVVPDVKQTVTIFSCNSLNKHVITGPNMGGKTTYLKTIAVISILSQIGSPICAESAEIRIYDQMFTKLAQNDNFEKEWLLATSILKKSTDHTLILLDEMGRSTEYSSGLSFSVAFVLALCRGTLFFSTHFLDMMKYLKDAKNVNFVGVNDFKARSGVCGYFRGIELARKYFPRKVIEYAEKVCKKWRIKDCNKIRMQVALKIVEGKCDERCINKQDSRKNGKTNILSLDKDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYT6</accession>
    <name>L7JYT6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993863">
        <property type="protein sequence ID" value="ELQ76181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0855"/>
    <dbReference type="HOGENOM" id="CLU_999498_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYT6"/>
    <dbReference type="OMA" id="DELCNSY"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979265" evidence="1">
        <location>
            <begin position="27"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="279" mass="31534" checksum="0DC787B3F0EC0712" modified="2013-03-06" version="1" fragment="single">MEKQSVNMQIFIFMLLFSCTYRHTGSDQYKNEKMNEGCSLSLGKYDNLSTEELYAIYCDEEDMKIQDKCVEDEQLKLHFIAKNQRSSAREEGVKIEKKLKSKELNNSSTLFEDKNTNSVSTNSLNLIKDGALPPIAVQQSDTIARRIGSLMTISPTEHATENREVGCNKLNPLELNKETYPNPMDSSSCVSPIAEHPNPVNSPSFNPAQSSQTKSINVTHFNHVDQAQFESINPTNSENLSDLIRSTGLDHNVENCKIIQDISDSLTFNKRFTEFLDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYX5</accession>
    <name>L7JYX5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Drug/Metabolite Transporter (DMT) Superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0792"/>
    <dbReference type="HOGENOM" id="CLU_894874_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYX5"/>
    <dbReference type="OMA" id="PSMIASW"/>
    <dbReference type="OrthoDB" id="10377025at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="311" mass="35368" checksum="F4B75B34ED2E78EF" modified="2013-03-06" version="1">MHKIKFLRNLLMSAVIVAAGILKNRLYYNEFPVTLPSMIASWGALLVSYFMAQEHKLPDRLLSLVVVILVLYSLVARYCSKHMDCLVIALCAPSKVIFTCILAKLFFELQLSRWQIFGLSLIIVGIVLPNIIIADSDFSSISPQKIGVCIFAGLLFSLLNLTYEFHQRKKKPFFWNLVFTGSIIGVVVSTGILATEMIKSDSTFKLLAQRKTTYILLVAEYVELSLKAFLLYVTSPIYRSIILIFLSIFTGMIDTVIFGWETIRIVDILAFITANMGLIIFDYSELKKMFIAKEKQKLDEDDIEKRQIECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYX8</accession>
    <name>L7JYX8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RuvB-like helicase</fullName>
            <ecNumber evidence="10">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="10"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYX8"/>
    <dbReference type="STRING" id="72359.L7JYX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0367"/>
    <dbReference type="HOGENOM" id="CLU_028311_4_1_1"/>
    <dbReference type="InParanoid" id="L7JYX8"/>
    <dbReference type="OMA" id="MGMRYAI"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 10 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="87"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="396" mass="44925" checksum="8CD89F7BD6918F19" modified="2013-03-06" version="1" fragment="single">VRFDVKQALYFYSAHNSWKYLTIKISNNPKFSFTLMTIESKDHRSIDRIGLHSHIHSLGVVDNRTHENSGLVGQEKARIALSLSRERSRIVLLHGPRNSGKSALATALSKDTENCVYISAAQVENVEDLDKLILSVQVVVLMEETTVIEGEIVSISGNSVILRTTDMESTFTVREVVGFTEGDVLQIVNGTIKRMGTTRTSESVDPNVPIVGIPKGNLIQTKILKKRTTFADLIENNDKNADKYLIYEKVREWINENKAEIPKSTLIIDEAHLLDERLLNYLFKISELEYSPFILLVSKDDINETRLLKIRTSNYTDKEKEKIFKLRGIEEEVTLNDELITNLLNIERNMGMRYAINVITLVGALSSFHQRDPNLNDLKCVSELFLDVGRAKEGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ03</accession>
    <name>L7JZ03_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0777"/>
    <dbReference type="HOGENOM" id="CLU_108611_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ03"/>
    <dbReference type="OMA" id="NYEMAHG"/>
    <dbReference type="OrthoDB" id="2192459at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031547">
        <property type="entry name" value="DUF5089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17002">
        <property type="entry name" value="DUF5089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="216" mass="25260" checksum="A23BB04A379CE5E2" modified="2013-03-06" version="1">MKDLYSAQNYQKFLQKHKKKEKRSAVDEEVEARAKQIEEQNYEMAHGARKKLEAGYATQKKTTKELQSQGEKLERAEMSARSIEQDVEEGKHLTRKIKEEGKMFNFKLPFVGRIKKIFKSKKQPGHAVHTHKKERQAAPKPQDESEIVTDKNLIPGQQKTDKELEQIYRTLKNVKGEAQQQHEEMARQTQNIKSIGKRTQKSEKEMENVTEELKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ16</accession>
    <name>L7JZ16_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polycomb enhancer protein, EPC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ16"/>
    <dbReference type="FunCoup" id="L7JZ16">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0402"/>
    <dbReference type="HOGENOM" id="CLU_080496_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ16"/>
    <dbReference type="OMA" id="CFRKRII"/>
    <dbReference type="OrthoDB" id="2192095at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="308" mass="36841" checksum="6286F64CB3D1AFF4" modified="2013-03-06" version="1">MFSKRIRNKKLETNRQLMVYYTDELDQSLLLDYVHTNLKTGVEQDEEKEIHLKKLLESGKGDIVIPKITVNTDIVKNYGEYRPPEKYIKHGRDVPNEYVLQEEDYKFLEDEKIELSDFKRITKMIGTKEYEKLENSSVKEKITNYYSKRMVKLIGNDDYDAYLCFRKRTNVPGRKNRRSEASTLEKLKRAYLEFTYLDKLLSLKEEQQKLNEEILSINYEIFGITDVLKTSCCPSRRKKIYRKLYRKEKIKKPVPFYKTCSSFSDLLADRKKIYDLKKTLLNPKRILSEKEIENESRIMSRINKKNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZA7</accession>
    <name>L7JZA7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin thiolesterase, ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.1.2.15</ecNumber>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.2.15" evidence="2"/>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0927"/>
    <dbReference type="HOGENOM" id="CLU_1908167_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZA7"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="133" mass="15332" checksum="7C268834EE6E87D6" modified="2013-03-06" version="1">MVNNEFITNNHIPARLDLSDLIYKSKVNEKLVDEILSLGFSRHEIQRALCLMNNNLNKSIELLLNTGGKVSDNSEFELFGGVKYYTTGMNNGHYIYVRDNVVIDDKDIRKVKINEKFYKHFLVLVYKSAADVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZF9</accession>
    <name>L7JZF9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zn-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZF9"/>
    <dbReference type="STRING" id="72359.L7JZF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0203"/>
    <dbReference type="HOGENOM" id="CLU_084834_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZF9"/>
    <dbReference type="OMA" id="WNVKMID"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="259" mass="30375" checksum="6F1A122D90DE74EB" modified="2013-03-06" version="1">MKADLKQHKQVFKDLLEIAKKLQNECKEGDNVADLNPYNIDLKLKIIKEGNEIYTREEDYNIFIQLFLESIDITLSVEEFAQKKVKFKGINYVNLSDLKDEFSLLNEANDEDEIAFKKIKTNDLNYLDKKPFLGKNEQKEAWNVKMIDSIINNIFKKECSNSSSENVRPRRKKSKGTDLSSRPFVCQYKNCSSAFKRFEHLKRHYRIHTGERPFKCKYPGCFKKFARSDNLSQHLKIHNTGQGNYPNDSTSFYENKFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZH1</accession>
    <name>L7JZH1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear protein export factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZH1"/>
    <dbReference type="STRING" id="72359.L7JZH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0416"/>
    <dbReference type="HOGENOM" id="CLU_036727_1_0_1"/>
    <dbReference type="InParanoid" id="L7JZH1"/>
    <dbReference type="OMA" id="CFRERPF"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="133"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="618" mass="72612" checksum="75D07125A3B4E287" modified="2013-03-06" version="1">METLKQEYDRLLNERSKKQAPIGKINGSCQSFCPYFEMVERRLRNDVSRFEKDFMIKKYVRSAAGRNKALEEDVRPLPVLCSCFDYLMDVLEGCCKAMENAMRPAGADESANLAISTPNSTDDKDLDIDGVPSLFEVYKFVEDRTRAIRLDISVQELSCGRTVVLLQQICNFHIVFNCLLYDDEKFEEHLNADQIRRVLLSLMECYKLRRSVPMTLDQQRYYSYNVMLRISSDTACYGDELFSTDDKIVNNSTHSQYEVINDAFDLLSAVQRGNTSRFFKFMKHADFLTRCLLTTQLRYVRQAAMDMFKMCFYEKIDCSLVMSWLHITDRTYFEGEGVKIEDDKLCFRERPFVPREVHARLLPAYAVYPLQNIANAIKYDVYEVFVRKMVLHEYTRLLIENFMTRKKVQYQSQPGISADINQVMIFIYRKYAYHLSIKMVLNNIYIQRMDLIVKWQQKAKKKRNKRKLLLVVLEKTVSAAMFRQRVKNSPLKPSFIDYRPDLNVEEMLPYKMVLFVTAKKHHEQIKNTFYMLNKVVCLPNSPAINLEQIVESANYIVKRKLSTMIDVSQKEKTMAVMCSLIENKRNPQLKDVMIKFERRGILDDIDVYYEDKDGTNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZI1</accession>
    <name>L7JZI1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA helicase BRR2, DEAD-box superfamily</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZI1"/>
    <dbReference type="STRING" id="72359.L7JZI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0431"/>
    <dbReference type="HOGENOM" id="CLU_294953_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZI1"/>
    <dbReference type="OMA" id="DEYDWCY"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17921">
        <property type="entry name" value="DEXHc_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="100"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="320"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1027" mass="118468" checksum="39B4E47346A5A1DB" modified="2013-03-06" version="1">MEFNLFHLIRLLSPEQIKAYIKDSEVPPNLPLYLTQQLKDNYVAYRNIFAKLNCEETDLYQRVTLHAGESSSFKLRIRNKMLKRMLGGNFYLNVCQAAALEFINAECNVVICSPTGSGKTVMALFFILRALGYDIATEDGGNADEQPHAKQTDKPSNHTRTAEKTRIVYLSPLKSLCSQIFSFFADKLSRLINVSIATSDDSLTRSQLMESNLIISTPEKFDSILRKYVLPVDLLIIDEIHVLNSDRGAVLETMISRMIGTCRMLGMSATIPNLKDICRFLKAKAVHFDSSYRSVPLQMNLINIRNHEGAVVLARNNLSVLERLLNEIEGNTIVFIRRRAEVEECCAVFSKHSTYKCLYHHAGLSKSKRTSVESSFMLDDSRKVLFSTSTLAWGVNLPADNVIIFDDFTDYDIVQMMGRAGREKYHKPENVAKAFLITSNVDRLDLICNLKPIRSRVKHLEDVYLANLFLRSEQAFENTLYFLERAGQIAKNVREEDWCLEGNQQYGKKDTAARITTKCETRVLDGCSDRETESLRKRHKSDEAVTKLHEHVDKTKCRNDDYNRAMIPKENTKNNITIQNSTYSRKYHMFNEVIRNLCDHQLIFLNNGVFVLSKVAQIAVIYTIHYKTAMRYFEQIRNFRTEEEIFLILNDVEINGTYTTQHLFPTDTMVGKYVQYCILKHKRINDTIRVILRQLRALLYLSNEKGTVRGSKLILRLLLMIENNVNTRKEDSVSTENEDHSFEDVKVDGSIFKSKRPAKEYHLFVSDPLDNTLVCYRKMKNKNLDFLDLHGVFLVCFTGTNGCEESKIITFGLNDEKCSANYESHQNLRPEIEDAARKDGLINTVKPKQLPYIEQKRMDKQVLRCLSVYNRKLTIVDNDVMDCCSSLIIYRHYFVKYNGKGILIFAHRNAYSFFHKNDLNMQCYYIVDYLQSNDTDEYDWCYIIGTDLNEYDGTEPELYCLDILFFINSRTFYVLGSGLNTKTCAVSALENLKKRFSITNTFSLSMIEALKKHFICLKEETTGENVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZI7</accession>
    <name>L7JZI7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin remodeling factor subunit, transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZI7"/>
    <dbReference type="STRING" id="72359.L7JZI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0136"/>
    <dbReference type="HOGENOM" id="CLU_1437762_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZI7"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMARCC C-terminal" evidence="3">
        <location>
            <begin position="116"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="189" mass="21715" checksum="3077738004393BC2" modified="2013-03-06" version="1" fragment="single">VTGRVVVKKILKKVLKRMIKGVSTRALKKVLTRALTRALKKALKKVLRRSPNESPNESPNPSPNESPKESPKEDPKLTTLDKETTVNKEQHSIAHDNYESTTPNQNIKHSILIKNALKAAQHKAKELLTIEENKMVRLVKVILEAQMKKMELKEEAFNDLKGNFKNERIELMKIREGYKSEIEEIKKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZL8</accession>
    <name>L7JZL8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative E3 ubiquitin ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993863">
        <property type="protein sequence ID" value="ELQ76172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0845"/>
    <dbReference type="HOGENOM" id="CLU_026075_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZL8"/>
    <dbReference type="OMA" id="MSIRECY"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF15">
        <property type="entry name" value="OS01G0568000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="678" mass="77141" checksum="A80770D22BA57503" modified="2013-03-06" version="1" fragment="single">VILQSKTANVMMYNLTVILTFILXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQSNASPSRVTTNDHSPIKHKNSPKNITKHNTPIIPQNDMHDKLQIQSIEALESIKQLLLQKCNQCAHTLPSFASLREHYKEVHALVLCMLCQTNKKLFSSEYETFAPRELAVHKRYGDRSVGFRGHVYCPFCKEYCYDERGAHKHAIKHHFLCTLCDANGLRNRFYRDSKDLQMHSHNLHYTCFLCRNNLYFYRGEVVVHLEEVHGIRKRMEEIAVKRDDTAYFDPYVERNVGKGSGESSRGKGRGSSDWGSSDRASRGINNVRGNDGSSDRTSRGINNVRGNERSSDSRSNPKNNNINNADPITAPTTNITTTNNANVNNNDAADKNLRKRNVQRGNKNAGSKFNSYFYESTDGKKINLEFVEHNTKNKVKKEEINKIENEVAFPSFGVDGPADKTCSGPEYLSLNIIRNEKMKESRKMQSIQKIVKGAKSGEVYNMVREYEHGRMSIRECYDGMCMLVSNREAFKVLDTLIKTGLMEREERKAFEQIKRECEFPCYKRDEDKNGRIAAAGKDRDVKMKFMVLNLKGGKKKNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZP2</accession>
    <name>L7JZP2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ76909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0105"/>
    <dbReference type="HOGENOM" id="CLU_2814234_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZP2"/>
    <dbReference type="OrthoDB" id="2190755at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="67" mass="7918" checksum="F89AC9DD1F190546" modified="2013-03-06" version="1">MSYSAEIKKIFIMAMESSYRKKEINEIITRIAGKMDKLMMEEGDLESLKREFESIRKDFNGTINHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZP7</accession>
    <name>L7JZP7_TRAHO</name>
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        <submittedName>
            <fullName evidence="5">GTP-binding ADP-ribosylation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZP7"/>
    <dbReference type="STRING" id="72359.L7JZP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0813"/>
    <dbReference type="HOGENOM" id="CLU_040729_10_5_1"/>
    <dbReference type="InParanoid" id="L7JZP7"/>
    <dbReference type="OMA" id="RFRSEWG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="200" mass="23466" checksum="AACAF4756AAC1DA5" modified="2013-03-06" version="1">MVSTRRRNRGLCAGIKRRFRQLYEYFFVKNLKVAFIGLSDSGKSSFVSPLFENEFLQDMNSPEVRIHEKKMDNIKVLIYDIPGDPSSISKWDHYYKKSDVIIFFLNSTADEETRKKSKNELHSLLYRNMWMRKNLLILGTKNDLPDSMSCKDIILALDLMTIGDREVACYSISNKNLVNIDLVREWIVEQAALVRETRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZW3</accession>
    <name>L7JZW3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0006"/>
    <dbReference type="HOGENOM" id="CLU_1256825_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZW3"/>
    <dbReference type="OMA" id="RMKSAVY"/>
    <dbReference type="OrthoDB" id="10340375at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="220" mass="25497" checksum="F64E7DA18F841257" modified="2013-03-06" version="1">MLTSLSIKDLWVTSNATFIALYSLYVSSWIIRLPFAVGVPRIMTNMSVATAYFLTLYPQKHNLDLILENTNTFCLLFFLTNPPLLYMLPFYISSIVNISSVVITHPKLKRYGFASYCHGINKNRESIIMISYIIELCMIPLVVLFSVLGYSSFFNMVSYGLLIRMSLKIDMMMRRALLIILQVIDSKIVNLPKDWQKLYMDLKDYMQVKHMVVSEEVKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZW8</accession>
    <name>L7JZW8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family DNA-dependent ATPase domain-containing protein</fullName>
            <ecNumber evidence="7">3.6.1.3</ecNumber>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.3" evidence="7"/>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
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        <property type="protein sequence ID" value="ELQ76287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0737"/>
    <dbReference type="HOGENOM" id="CLU_277156_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZW8"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="427"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1146" mass="129355" checksum="9C80DBE3DF4070C1" modified="2013-03-06" version="1" fragment="single">VFHVVNEHFLDVLRCACFNGEGFYREWLVVEENDGVIWWYVYFLVRDGKELCYDDRSIDEEDRVVDGEGIEEGVVDGEEGSNDNDKDSIKDSIKDSIKNSIKDSIKNKVKDKTTLKTNPKTTLKTNPTPKTAPLTPANPTLSSKTNNSPNINTLHKLHMSLLIPSIIHHANPSFQHAFFKHLNTSFYRIKNYRSILLNTCIPVLAIIAQHIHLERIVCDRIVDALYGDEQVEYVVRLVDLYMPSTYGERIVGAVMRRGLTVGVVRVLGRARFNEWLVLLVRPLLRFISLKDVVDKGRVIEDRMGDSGMVDDRDGVGKDTGRVSTKDKNNIKNNIKNSTPNLSPTPNLNTNPNHNTNTIDIPQRVTAGYKLFSNIVPFIQTVRSTHPRITHELSVLSVLTNSKKLPKIAIHSRVTLRKYQVKGVYWLNFLYLFGINGILADEMGLGKTVQVLVFLFSKIDEIKGSDRGSKGDDNDGVKDCDKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTLNTTLDHNTTLNTTLDHDPTLNTTLMNHKILIVCPGSLTGHWQNEIKKITNVYEGHIYTKKDNVLSFITIISYDTYRHAYRAFTDHTFFYLILDEGHILRNVDTALYHKISALRALNKLILSGTPVQNSINDLFALFNLLMPCYLGDKNELKERERRIRKGKDRNCGEEDVRMMEKELRMVRRRVGPFVLRRCKKDVVVDLPDKIVKDLVVVMGDEQREVYEWLLRDCDVVKDCVVKEDVGEGVVKEGVGEGVVKDCSLGEGVVMDCSLGEGVKRRGRTTNNSLNNSLNNSLNNSPDNIPNNNKRLKTAQTAQDDTLGAHVDSAVSYKNINSFKKAKDLIKCCSSASYIREGVNQSCKIDALKDLYGTLNRTDSRILIFCQLRRSIRLIIDELALKDYLILDGQTRDKSGVVRRFMAGDYKTLLLTTSTGSLGLNLCIADTVIFFEHDYNPFNDLQAMDRAHRIGQRRTVSVYRLIVKDTVEERIMNLQEFKKFVAGSVIKKGTGEFGGDVSGESGVEGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZY8</accession>
    <name>L7JZY8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0693"/>
    <dbReference type="HOGENOM" id="CLU_2869239_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZY8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="64" mass="7881" checksum="A3677B5C84C1E1BC" modified="2013-03-06" version="1">MREIRIGEDRLTEGGRRDDRLKEDRIRENRIRENRIRENRIRENRIRENGIKENGMKEKCIGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7K046</accession>
    <name>L7K046_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit K</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K046"/>
    <dbReference type="FunCoup" id="L7K046">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K046"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0578"/>
    <dbReference type="HOGENOM" id="CLU_112527_2_0_1"/>
    <dbReference type="InParanoid" id="L7K046"/>
    <dbReference type="OMA" id="TYMTKYE"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="119" mass="13956" checksum="79E1CA068D062D37" modified="2013-03-06" version="1">MDYDHNSESSTTETVVIKERPPSPPKKSNKRVTSPLMTKYEKTRIIGMRAMQLSMNAPPLVEIEAETDALRIAEKEFYARKIPFIVRRRLPDNTYEDWNVNELIYPDEGIDFAKYEMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7K047</accession>
    <name>L7K047_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K047"/>
    <dbReference type="STRING" id="72359.L7K047"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0400"/>
    <dbReference type="HOGENOM" id="CLU_872052_0_0_1"/>
    <dbReference type="InParanoid" id="L7K047"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="319" mass="36826" checksum="DA018914E9E2AB1C" modified="2013-03-06" version="1">MLLREYNSNLGMEVALELFFNSLDRKNFLFQKMFLQFLGMSGSITLEVLHLLVPRNAPHFCLNFIKLCKYFITDFVQVRREGSSFDSLKICKEILYPLKYYREECNLILNEIQDFFRHIEILTRENDAEVVGGKGIVGTAENAAQKKTNVKLTDIYMQKNINYGLFYDIADFFNSKLRNNKFVTLKNLFNKRRRRVYSKSFDFSTTDSTYKSIINYAGDGLANIILTNSVQRDVAITALVDNLSDENAQGYNQNCNAILYLSENDEWSENLLGLIFYRVLGNNPPYLLAKVCKELMCRENKKIGGSVRERVSEAVKGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7K086</accession>
    <name>L7K086_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Tetratricopeptide repeat, Tetratricopeptide-like helical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K086"/>
    <dbReference type="STRING" id="72359.L7K086"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0225"/>
    <dbReference type="HOGENOM" id="CLU_417495_0_0_1"/>
    <dbReference type="InParanoid" id="L7K086"/>
    <dbReference type="OMA" id="IAMFDRY"/>
    <dbReference type="OrthoDB" id="2190529at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="657"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="738" mass="85914" checksum="1657375B0A4D6DC1" modified="2013-03-06" version="1">MDKMNEFILTNLKSIKLHNNPAYRPGIARIDLIEQVKHENVDFITYLFIMYKCSVENEKYKNLILENIDKVENLLVRANVLIELDMLSAAEECLERYKRMIGISLEVIGAQAVFKKYNCVENVSYVLDVTYRNGEVDESRRVDKEVDESRRMKEVETGHEMSNAVESRRMEEMSDAMQTNEKQQNGKTALTNKISVSGDKNVQKTNCSDHHAKNAHGKRKLYKFETRAHVFKEYRVFPLHVHEQCLLLTIVQLLIKSQGPEHVEYARAYLDRVLFNGNDHFDTKDYLQNYYKNVLYDETIEPCYVRSFSLEAPLVLNYEYAHVLGNNFFKKYFFDSALGIFTCLRMHEKMAKCYLGMGKETEMIEELERMREMMEIKVFGRVVGLEKETDVKEAVVNERLVEGTDVEERMVEETGVEERMVEETDVEGRMIEETVVKESVEAVVNERMVKNSLETTAKVSLEAVRVPLEAVKVSSEAMVNEAGKERKTMVRRAEEKNEILKNNVETMKESENDVEMAEKCATNTKTEDKRVNEEHVHGREWRTNNNLSEKGCDTRECSSAMFDLVNTYNLLAELTGRAYYYALSYQTYKTYTPLKLEALHRIRNKEYEKALALLKQALEHAPYNITLLHMTGCLETALHGNGITYFLRILSIDSNNYETLINTGNYYTEKEKYEDAVYFYTRAYKINKSAKVLKHVVTILEMAGKYDEIRKMLSREDRGSVLFAKDKEIIAMFDRYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0B6</accession>
    <name>L7K0B6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993809">
        <property type="protein sequence ID" value="ELQ76871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0B6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0130"/>
    <dbReference type="HOGENOM" id="CLU_572647_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0B6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="477" mass="54322" checksum="764CA122F9FABBEB" modified="2013-03-06" version="1">MTLFPSSGTFELLRSGDIIEKIMLINVRFNNSVITIPNNIQEIILKNIVLGGVGLWVFPEDIKKITLEKFSGHVQLNGFTQDEPLVGHFNDGTFRLYKSNESKQIELVFSRMYLTHGLYFHSNISRVVMSCVSIDPEFSLKFNEYITEVSLDNCTCNLCFENLPCLNQIRLEESSFGEPHQNFCFKRSDERIRHLSMSNLMIEETINFGPEIQDFKFDNIIVSGSSHISFDENFNELELNDCKGRFKIPGIFSDDESCTITMDGNVDRFEIRRTKNDSFDILIVIFSVDKLIIEMNLKTVEFYNIEVITIVLITTHQCENLIMCGFNCTLSMPNIVSLKKLELSNFDNLTISSKMFTLTKDVTVNVTSMNEDNNANLSASDTNVYFPIIISDYCENISIFKNKIPVNITSVLRNASIDESLMRIPPENKFEIVTCSPKHPSKLKLHGERICGTATIEKNVCFLSLSRISSDEGSELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0C0</accession>
    <name>L7K0C0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_0122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JH993807">
        <property type="protein sequence ID" value="ELQ76881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0C0"/>
    <dbReference type="FunCoup" id="L7K0C0">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0C0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0122"/>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="InParanoid" id="L7K0C0"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="434"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="605"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ76881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="757" mass="84800" checksum="A40D3008D099673A" modified="2013-03-06" version="1">MCGITAYINHRIPRTQEEIGKILINGLKRMEYRGYDSAGLCVRNNDGFTIIKKTGKVEELARAINILTQDTMESSVSIAHTRWATHGFPCEKNSHPISSDINNEFVVVHNGIITNYKELNEFLKKRNYSFHTDTDTETAAKLALYFYERNKNASFMSIIKNVVRCCDGAFAFIFVSSHFPNEMIAVRKSSPLLIGVKSNSNLSMDSFNVHFDESSVDNVQSIDNVEERVEKIYKFTEENSKSDDMSLSGHSISSDATSRDAAILPISPSYSNTGVLNAEEGSNFTECQTEDLRTSPTSLKIKVKDNEQIEYFLASDTSAIIEHTKKVIYLEDCDIVRIKDGKLEIHRFSDIKTESKRFINTLEMELENIMKGKFPHFMLKEIYEQSESVVNTMRGRLQLSCTTGESEKDVAEKICQEAGKDNWYKIKLGGLDSYIENIKRSSRLIFIACGTSYHTAMATQSLFEELIDIPVSIEIASNFLDRQCPIFRSDCVFFISQSGETADTLNALMYCKSKQALCVGITNTVGSTICRETECGVHVNCGPEIGVASTKAYSSQFIVLVMIALVLSSDNLKHEKRRKEIVDGLRDISGLIKKTLEIDEYIKVLAQKICDRGDMLILGRGYQHALCLEAALKIKEVAYMHAEGILTGELKHGPIALIEPETLVIMIITNDHVLKKSENAVSELMARRGKPIIVTNNELVDQFKKMGCMTIGIPTTVDCLQGLLTVIPMQLLSYHLAVIKGYDVDCPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0H2</accession>
    <name>L7K0H2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993826">
        <property type="protein sequence ID" value="ELQ76727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0H2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0281"/>
    <dbReference type="HOGENOM" id="CLU_1939592_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0H2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979030" evidence="2">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="130" mass="14797" checksum="DF05AC195FC9B6EA" modified="2013-03-06" version="1">MERNRTIKENVFIAAMRFLFLKLYNLFMSGANSDDTSVANETVVEKESPLAGPNEWVIVQYPDDSHLVGKSEEQPVEEESGLYSFSEACMPFEPEPHTNIQPWSRPTEPREQLTNPLRSGNTSEESRGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0I0</accession>
    <name>L7K0I0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993815">
        <property type="protein sequence ID" value="ELQ76767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0I0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0238"/>
    <dbReference type="HOGENOM" id="CLU_2575549_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0I0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="9095" checksum="698F98FFFC56DA4A" modified="2013-03-06" version="1">MHHVLQRLLYCAIPATQREAIRAVKPKVVVRLLHTGRSVISSFGQVNFINSSLPSWKVIVANPAIYSGKGGIHQVRFYVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0L0</accession>
    <name>L7K0L0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0L0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0114"/>
    <dbReference type="HOGENOM" id="CLU_2905757_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0L0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7548" checksum="E5F8D610BFAB04A7" modified="2013-03-06" version="1">MLLTQLIIYFTMAIAFYRKNDRAELIRLALEHEKMSMMDEDDMMAEHLRQEGFDVIDRRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0M4</accession>
    <name>L7K0M4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome biogenesis protein-Nop58p/Nop5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0M4"/>
    <dbReference type="FunCoup" id="L7K0M4">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0M4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0014"/>
    <dbReference type="HOGENOM" id="CLU_015495_1_0_1"/>
    <dbReference type="InParanoid" id="L7K0M4"/>
    <dbReference type="OMA" id="NRMMVLA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="3">
        <location>
            <begin position="207"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="351" mass="40463" checksum="FADE1AFF39E9E7CB" modified="2013-03-06" version="1" fragment="single">VRVFEKNVGKDEYLVVNDKELVKSLEEKKIKAKEDVVLQKRLKIEIETRLLKHFNLTEDEFKNKWRYIADNIATESLHVQVKELDTMVIQSIKLYDDLEKDINMHSMRIKEWYGLHFPELSNLIENNEKYLRAVDRIGDKENLSKMKDDECMEFDLKKVRELARNSVGSDLRDDDIKKIKEDIACVLNMITYRTELVTYITEKMNEIAPNVTELLGVMIGSRLLVKAGSLAALSKMPASTIQILGAEKALFNALRQNGKTPKFGILFHAPLVSNCVNKGRMARILAAKIAIAARVDYYKKDRDGSIGKKYYEQLDKKRQKMQEVGSKGVLVRKKPSGKSKVERNDVKRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRA3</accession>
    <name>L7JRA3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA replication factor/protein phosphatase inhibitor SET/SPR-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ74003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRA3"/>
    <dbReference type="STRING" id="72359.L7JRA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3096"/>
    <dbReference type="HOGENOM" id="CLU_125119_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRA3"/>
    <dbReference type="OMA" id="FRENDYD"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="186" mass="22269" checksum="65290A62B1F91F05" modified="2013-03-06" version="1">MENNNDLEKKLNVFQSKVDQEYKEFAKNDFNVKLEYFNSLKPILKERDDFIQDLPNCDEGANFWEKAAQNCPSFRDLLPLDEEDFSVSWIESLRCWYEENYVCGVEITLSRNDYLNNRRLSKKFSLLDHTSEGTDLKVKKEVECLLFDFFRENDYDLEVFDILYELYINGAYYYCMCDESDSVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRC9</accession>
    <name>L7JRC9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3056"/>
    <dbReference type="HOGENOM" id="CLU_3351392_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRC9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="37" mass="4287" checksum="0F441CE3AAC24E49" modified="2013-03-06" version="1">MPDAEIKVGISNKTFMYVAVSILLYIFRFYENGSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRF1</accession>
    <name>L7JRF1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase (Reverse transcriptase), Non LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994088">
        <property type="protein sequence ID" value="ELQ74009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3075"/>
    <dbReference type="HOGENOM" id="CLU_2203405_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRF1"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="12142" checksum="4B9E5E02E4077369" modified="2013-03-06" version="1" fragment="single">VERVCSCSGSKKGGLDFLDHYRGISPTSTLCKIVTKICANRLSNFSEREKILIHKQAGFRKLEECIAHATSLYEIGRQRSLKGRATYAAFLDFSKVYDRVPTKVCLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS08</accession>
    <name>L7JS08_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA helicase PIF1/RRM3</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS08"/>
    <dbReference type="STRING" id="72359.L7JS08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2902"/>
    <dbReference type="HOGENOM" id="CLU_001324_4_6_1"/>
    <dbReference type="InParanoid" id="L7JS08"/>
    <dbReference type="OMA" id="TIRCKQP"/>
    <dbReference type="OrthoDB" id="2193682at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF48">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="125" mass="14336" checksum="1D04A60D6E932725" modified="2013-03-06" version="1">MVDKLNNNFIIAMIVTGYTKGNRAIILKVDMAQSETQLPFILKQKQFPVLLPFAMAIHKSQGQSFDKVGVYLHSPVFVHRQLYVALPRVRHADDLKVYIADNGDQDKADNNMVYTRNVVYNELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS46</accession>
    <name>L7JS46_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2846"/>
    <dbReference type="HOGENOM" id="CLU_3260844_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS46"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4858" checksum="2763561869BBB170" modified="2013-03-06" version="1">MMNPRFGLNSFDPFIMGMGRGLGTPMPYYKSSLFLPSRSWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS62</accession>
    <name>L7JS62_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2756"/>
    <dbReference type="HOGENOM" id="CLU_1256892_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS62"/>
    <dbReference type="OMA" id="IPKIIVM"/>
    <dbReference type="OrthoDB" id="2195677at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="220" mass="25143" checksum="96B205698428FA97" modified="2013-03-06" version="1">MPSPDKIKKLMSACNISQHEAEQLLQLSNDDVDLAITIYNQKKDEMYVGSGLAVNKPRRKHTIKTYKNGVLLDDRFIEMDAAELKKLRTMIEHGEFDARMVGGKDNEMAEFEVENYDVDYGNTEPVRETVDYSKAPCVGKRIIPKIIVMDKSDQSVSVNIRFVGQVREVRVSKDCQVKDLLKFLFKYTKTDLVLLSQGKTIKMNDRVIAYGNSDLQIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS67</accession>
    <name>L7JS67_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994072">
        <property type="protein sequence ID" value="ELQ74130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2958"/>
    <dbReference type="HOGENOM" id="CLU_921927_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS67"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978670" evidence="1">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="302" mass="34749" checksum="7BD76971F9C47938" modified="2013-03-06" version="1">MLLALFFLGLFVHPMLTTYINDAIYDSSDFWEFWHEPAHRILQTKKKPCEYYMRVPKWFAKRLARMHKIAEDPRKDCGNCRLQKKVMWEIFSAVLDSTSHLESESFSMMPFYSRCLGSMTGRRDGKACEQTVGSKKLLSGICMDHTMEDVMRRRDYTGCYPGINIMCSPLCREAFGRAYNAWYISMKLRFPGIFFFLFTNSLKSVVDYLTLPLTTSFQLLAPSKVVDAVKYTISPFNWYCNAVPCLHFLMALSALEGDMVRVREGSEIQYYFKLYDFQATLAQNSMDYGVGPSAVGSSSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS94</accession>
    <name>L7JS94_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_3161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JH994097">
        <property type="protein sequence ID" value="ELQ73921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3161"/>
    <dbReference type="HOGENOM" id="CLU_1490013_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS94"/>
    <dbReference type="OMA" id="CAWISGC"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ73921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="21250" checksum="E13FE459ADB38FCE" modified="2013-03-06" version="1">MLIESILKRTIKVLELFLITITALYYITNLYICMRTRSLPSMYLLAVSLYYYIKTMRVHDYVPPNKHVHGVCMRCHHLRYASTHHCMLCDRCYDDRSHHCAWISGCVYGGNKNEFVFFVLFAVLHGVCNLNVVTCFVVLMGCGFLVVYFLRGNRVAMDWRRAGYVLMPWLERRAKVVDEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSA0</accession>
    <name>L7JSA0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994051">
        <property type="protein sequence ID" value="ELQ74299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2783"/>
    <dbReference type="HOGENOM" id="CLU_3093285_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSA0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="52" mass="5959" checksum="177A08F2596E3647" modified="2013-03-06" version="1" fragment="single">VSQQLKKELDGLDTFLRQKEQRLKDVSVKVKRQYNVLEAADATVEALEGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSF4</accession>
    <name>L7JSF4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2866"/>
    <dbReference type="HOGENOM" id="CLU_1086604_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSF4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="256" mass="30150" checksum="44135348CE8F335C" modified="2013-03-06" version="1">MLKISFYEVCPCGMVVRTEFEKIIGDLQNKDYVQVIDRISQARKKGASDPRIEIIYAYSLIQLKRFTEAQKVTIPKIFDSNYTYIVKCIFVGLNQAKSLKTLKLSDPLELYEVALLNYEYENCIMLGKEIKRNKNHFLVFPIIAQIIYETRTRHMELLSEIIRNSSYSTNCMYCLKSYGILNDEVYAFIKTTDKRDLCYFLILKEFLLMVGVYHSQWIETMQAMKKLLIFCLIIWMTGMFMSTLSRRTLVFPKDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JST6</accession>
    <name>L7JST6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JST6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2589"/>
    <dbReference type="HOGENOM" id="CLU_374540_0_0_1"/>
    <dbReference type="InParanoid" id="L7JST6"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="692"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="742" mass="86874" checksum="73A03CD3999F7E24" modified="2013-03-06" version="1" fragment="single">VVPLLTHEQQKEYGKMIISGRKPVLKNNIPKCLVLPCLYRAYLNNNDIRCTGYDIDTMELLQEYLDHTFVARFDIDEKHIVKMLSTLKINNSVFYAADRVPSNSFFYRSYRLRPFSCHTYKKLRVLRKICLHFQFVESLRIINTMLSIRDKEEIAIREEYVNEIGANKVFCTGNDTGLSQSVCKFIHGKNGDDTIYSYRSFGEGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSKNGYKSDEHFYDNLDGTVNFYEKGDDTVTYEYLRSLSLSFTKMCYIRVINRIIQSGYFKFTVLHDKKKEIYLLNNFIVKPHYIENENLKKLKVTLKFIQSDKLLRVRYFKREKYYELERVIERLSNDIFNTYVRMKSRRFYRTMMKVVNYFDDDVWYYVFIKSVSRIRNISAVLFLEKMILNSGRDISGNTGIEAIDSVAVLADSERKPRNHKNMELSRFLVQQHSPLFKCVREEFAYNFPSLLPLLTNSTIKIDSCIRRELKNKLHNVKLKLLKVTNGYELIATYFINNEDIQCKILIHSDKRPTISTPRKDKFILKLNKLLEVSNRYVEVLSLWKINLDNKMMGRKECLICYYIVDMKGRLPNYECTTCKNIFHVNCIDKYRAQSNNPLCPFCRSIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSV5</accession>
    <name>L7JSV5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2471</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSV5"/>
    <dbReference type="FunCoup" id="L7JSV5">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2471"/>
    <dbReference type="HOGENOM" id="CLU_027721_3_0_1"/>
    <dbReference type="InParanoid" id="L7JSV5"/>
    <dbReference type="OMA" id="YHDISRD"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="111"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="332" mass="38650" checksum="57DBE828F5B898E6" modified="2013-03-06" version="1">MNAIAEKNPKWSIIKGLISSLLPFTLLYFYFTAIKVLCVDSLRFNSTSLYIYLIYTAMISYIIINYVRTMNDNKVTTFDRFPFTYHDISRDKRIEVSMAVKEQVIDKQVKDKIVCEYCLVYKPPRSAHCKECGRCFLKRVSHCYFLETCIGFHNQKFFVLLLASLIVHGMAVIIAFIIALKTTPLYKMVAVRKNQEYTLVFEAHFIISIVIAFIEVLICTCYLVFHLYLIFRNETNLERKALNLYKMNDDALDYVFTQGLVTLNTPDLNRDTANPYFLGYYKNVREVFGDGKWEWALPTYTMKGNGTEFELNCAKEELKAKTLVPVIPEHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSW8</accession>
    <name>L7JSW8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2698"/>
    <dbReference type="HOGENOM" id="CLU_1280458_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSW8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="216" mass="25377" checksum="1492A1C8A2B51B49" modified="2013-03-06" version="1" fragment="single">VNECFKLCVHLDRVWYVLKNHVSNDNDKTNNAIVYEHQINFYKCSIREMVIAKLFRLLKVPSTTITLYIFLARYECAYIAHNKMTISHDIIVNPFNVAFGLFFCIASNAVSVPVPKINDVELFTLKKVHDMLQHIALHVTTTNRYEIINNINHCMNVFFNNLDHAQQLSIKQAPMLIRVCRDENYPGMVSIFFDDIWMINEFFLEVQYAYLNRIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT38</accession>
    <name>L7JT38_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Apurinic/apyrimidinic endonuclease</fullName>
            <ecNumber evidence="9">3.1.11.2</ecNumber>
            <ecNumber evidence="9">4.2.99.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="9"/>
    <dbReference type="EC" id="4.2.99.18" evidence="9"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT38"/>
    <dbReference type="FunCoup" id="L7JT38">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2508"/>
    <dbReference type="HOGENOM" id="CLU_027539_2_0_1"/>
    <dbReference type="InParanoid" id="L7JT38"/>
    <dbReference type="OMA" id="MMNEYGS"/>
    <dbReference type="OrthoDB" id="2195130at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="359" mass="42543" checksum="BD3D1572D5B73397" modified="2013-03-06" version="1">MLFRLVSFNVNGLRSYSKFISERNTNINDYVRDRLKATILCVQESRGSKSSLSEFYSLKDYIVFVSANRANSGKYGVATFIKKDFFCCGKQEVMEEFREYNGEGRFLLTRHGSFDILNCYFPFVSESEFRSDDEVCRKKVNNAMRFYHYVEQYVNNNPNTIVCGDFNAVYSLKDTYIYQQEFLRIQNRAMMIDREMDGIVHAEHVVQRDDSEHEEENETFDRGRFVNPIASPTELPFFFKNEKYLREYFFELPSRKWLYKMIHECELIDTYRMYSNKEKVYSCWNSLLGLRKVNLGTRIDLILVHKMYVKCVKNADVMMNEYGSDHCPVYADFEVEIVANGDNILKRNNNLLSFFKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT56</accession>
    <name>L7JT56_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID, subunit TAF5</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT56"/>
    <dbReference type="FunCoup" id="L7JT56">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2600"/>
    <dbReference type="HOGENOM" id="CLU_005884_3_0_1"/>
    <dbReference type="InParanoid" id="L7JT56"/>
    <dbReference type="OMA" id="HLDMVHC"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="6">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="460"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="526" mass="60246" checksum="20B3D3102BF3C993" modified="2013-03-06" version="1">MIDDQGYAKLKAWIEDSLDQFRNDLMNLLYPLFIHIYLDLLFANDIKGAKEFFNANKDDFYNQELQILESICTPQHLNENTLVSAYRTNKYSISMGKYAFDLFINFLERNQMTQILVLVNQYLNIKVHQGIKKNEEIEGLTEKINKNITLDTNLYSSYTEEAILKDEQYRYDHLESFVLGLKNRNREKEKVMPSSSFIKQEIENLKDLCKRVSLNKNNLPSVCCYTVNNTFERVCCAEISKDLKLLALGYSDSVLEIHALEGTLKKLKNTADLMKLKNLDEDLYEDIGKSTRLIGHTTCVLNVKFFNSKKYVLSCDMDRVYLWSLDLFCLVSTYKACAFPIWSLAISNNDLMFCSGGADRTVSLFNIDSFSPERLFTSALSDVSSLVFHPNSQYVIFGSCDHRIRMHEIESAELVRVFIGHTDTVTALAVSPDGKLLLSGSKDRTVILWDIMTSKKVNVFKGHTKTVYSVSFCYFGNVFVSCGADLSLRVWDFKNMLAVYHTKNTPLIDAKFGFRNIVSCVGPYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT81</accession>
    <name>L7JT81_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2417"/>
    <dbReference type="HOGENOM" id="CLU_2764972_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT81"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="70" mass="7267" checksum="D6A61C5B10CDFD96" modified="2013-03-06" version="1" fragment="single">VVPGGNVQLVGGCTANVTSQTIGSELLTTQSSGAVNNKTLATRNRTPATWAQHPHTEDGMALSATRLSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTA5</accession>
    <name>L7JTA5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2473"/>
    <dbReference type="HOGENOM" id="CLU_3144014_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTA5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5608" checksum="8FE969B28F16B868" modified="2013-03-06" version="1">MVNAGLMVDWCCNYVFGLKWLGAEIVQYRILEVELGGNEECGRRLRMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTD9</accession>
    <name>L7JTD9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2509"/>
    <dbReference type="HOGENOM" id="CLU_2711828_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTD9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="8581" checksum="406EBCB9EC3D743C" modified="2013-03-06" version="1" fragment="single">VLPPMMNDRFKEEEFKLNLPREWYAKKSSFENNQLVKRNKPNYTPSSSKDEVLTTTRDTRIPLLVSSYALMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTG7</accession>
    <name>L7JTG7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTG7"/>
    <dbReference type="FunCoup" id="L7JTG7">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2376"/>
    <dbReference type="HOGENOM" id="CLU_331556_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTG7"/>
    <dbReference type="OMA" id="PRISIYC"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="864" mass="102190" checksum="A44A6BBD62288963" modified="2013-03-06" version="1">MHKQMFNSWNDYENFNENKDLFRKLLNAIHLRRKYMRYGTVSKFSRYYYHNGVFYLVEDDVEKEKGDDINAFLNDYTTEKEQLFLSHTNLSAQIDSLSINTNVNVKDSSRHKNEIFKIPRHDDKNQKVLKPIPIEEYYSDCTYVLNVCNNRPIKSLSYRRLEHLKHSFNMYRNISAFKEKEEQQKKSRRDFYTVYKVDNHIHHSAAINCKHLLKFIKRKIKFNSDDVVYKKDGKTYTLREVFKHLNITVDELRIENIDTHSHTDTFHRFDRFNNKYNLLGQSLLREIFLKYDNFIDGRYLAELTKELINYYKENKYQNVELRISVYGKSKDEFYKLAHWIESNKLYSKHIKWVVQIPRLFPNLKEKYNIKSFGEMLQNIFDPLFKATEFADEKGKAFVCNKAYDDRYKGIAKMCTYRNLNNGAKTEHDKIQLSATNVSINNKDGTDEKKVSRKEEEYNKSLNNTHDPDMKITDYDGYMKRNREEKNTSNEAKNVNKAGNSCQHPIYSPNKERNTTFKGNCECHCLKNDSHILDRVDGIHGSCNTRNQPLTCLPEEKLQNSEKATTSSSIANFNGNNECICSLESINELKKNEKLEKEQKECSSKTNNEKYKMSLICNFLRNLGGFDTVDDESMRERKYHQKFPSPDEWIHSENPPYSYYIYFLYTNIKMLNDFRRSKKLNTFKFIPHSGETGDYEHLVNTFLTADSICHGVQLRKCFPLTYLFYACQIGVTMSPLSNNSLFIALEKNPFINFFNIGLNLSLSTDDPLHFHFTRDPLMEEYSVISQLYKLSSVDQCELARNSVIQSNFSFEWKKEVIGNFYKEGVEGNDIIKTNVPDIRIHYRWIMLCKERELIGYVITKRLGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTG8</accession>
    <name>L7JTG8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="1">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="1"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTG8"/>
    <dbReference type="STRING" id="72359.L7JTG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2535"/>
    <dbReference type="HOGENOM" id="CLU_013325_13_0_1"/>
    <dbReference type="InParanoid" id="L7JTG8"/>
    <dbReference type="OMA" id="NACYIAS"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="245" mass="28904" checksum="1208D5F952116C06" modified="2013-03-06" version="1">MQYECRLTVLDNDTVALTDLNRQFYYKQNDIGQPKVKILEEYLWQYHNVRINIIHKDVFEVCDYEYDLMFCCFDNVESRMQLNYISYINNIPMIDLGIEGLQMHVKRVDFATNRACLYCMKELYGTKAAFNYCTLKNTNTRNREAYIYSLSLKYESVEDVVEHFNAVNAVKTDEFEVRGIKENILPNACYIASLCASMALKMVDECKYDFIYYNGYEKVHFNFINMVVDPACILCNAKMRKPVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTI9</accession>
    <name>L7JTI9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2255"/>
    <dbReference type="HOGENOM" id="CLU_1662137_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTI9"/>
    <dbReference type="OMA" id="KEWDGCI"/>
    <dbReference type="OrthoDB" id="2188750at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="159" mass="18811" checksum="396329C7D5B63724" modified="2013-03-06" version="1">MRTSDIENIENKCVESMRNNDIEQFQYNFNMVKHQYNTTKTSLSTFVKACELMILLSTDFQGYLYFLETLDYEDISNEYIMFVLKIERLMTEENTALIKEQLGKYKEWDGCIHNIIKALENNDTKYKMEQISVVSKPAEHSPIQTIKDCILFSKNFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTN5</accession>
    <name>L7JTN5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2303"/>
    <dbReference type="HOGENOM" id="CLU_415733_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTN5"/>
    <dbReference type="OMA" id="FKINRTE"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="685" mass="78562" checksum="A38E4DF1D2E46B09" modified="2013-03-06" version="1">MLVYFLTFLCASSSNEDSNRKLGMFIKEFEEHEKNDTASQCKIDRGMHNVMGNKAHRESSFVTNFITTSYVDTNSEIGSAVCTSMVPSENEPFVDTNSEIGSAVCTSMVPSENEPLESTSFDHNDTVTQKNMVQWWCGSMSVFTHILNFDCHLNGKVLQSSGLKFKRIIQDVKQPNSVITIELLIKEDVMFRQLYSVCEAGRNIDFVALAKKGFSYLSYYKTDNDEMDYSVSTVQKSYSFFKRSISRGNSIKRRTLIPIGNEPRETDQDLTEYNRAMRTTKSYSKSLPDIGTKSNKSLVRRKFESFSDKICASISGRDHDSCEAFSSEFNAYKQSEKNRIYGKEGAVLNFSSSHGVVRYRMTMEFDMDKGKVRESSDMQQSLDHSEASKDLFVRNASFTLDLILFLAKYTNIGQKTGYNFYTENAKKGFIDELRNKIKVCGSHYNWQLRKLVQELKFLKEKSLKFLRDDNNLTLTQLEEYTKQLKLLQELTAFNQYIYNIHEFLDKITEIFNTFNLTLGRTLNNLNNLQNLIGKSALFTWDEQLLAISFGSTMNEVSKVSSTAATRLSYLITNTIPETTFEINSSPLENEDTLNASSHDTGATKSISEPYNTDRNNSIHYTPFSSCSRENDPQRLMSDHIKNLQNIRNDVLNLEKEMIEMLANLFFCNSFFKYVTHRFDDIINGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTP3</accession>
    <name>L7JTP3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTP3"/>
    <dbReference type="STRING" id="72359.L7JTP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2261"/>
    <dbReference type="HOGENOM" id="CLU_377755_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTP3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="734" mass="87196" checksum="38A10244E23F6BE3" modified="2013-03-06" version="1">MLKILRTQDALDRNDFEEMVAKIVQSQHFWCTDTELSTFLVANIHVFKTRSEIMKKIEKTFDWLNECPECLIAYYKLRETLCRKDNEDILQDLDDVRLFKIIKHSTRIGTTTLTEILTYNWKCLRICELKYNFVQQLKEFYRKENLVFSKMSFSLILLTQCGEPDLLGYVYKIFKYLNKEKLLYLHSGPEEWNYLLEYTGIDERFVPSHSLVAKRDWLMSILIYIGLESTFCTDEIVPIINRIYDQTKDADLKTMCFRVASAYRHRNGSVIKDFDLIFKNIFDDIKAESGKPCTSNVFLRDINLVLISQFRMFCLLRYDQQFYKYYSSKPEYIEAVTSEIVSNCDAIGDFVIFMDRYDFFVQIFSKILDKECTDSKEKKFVEVCMDRFIGNIYRSLRDKNFDVALYHRLFTKWYEISIAATGNRNLFKFFIYLFVFDVEKVLCAYKGSEKLLDVYKLFKKKTLEIFDRNGEPLSDELCFYSLLIKSDFSTYDVQSLVVSENEQHALTHVLKKMNVYFDRFQNFPACFTKMLRIVKKSHLVNYEMYVELFNFLWLGKNSKEILETLAALLPKVRVKCNIRETFLYDLDWIVILEKLDVKLRREVEEFIIAFYSWLRINNIGELPSYKRTRIRNLADYFGIFLINESAKTENNVQPKVKRVKNVPNKFSEEVDSRLEKESATAYKDDTKTHKKKQPTHQQIGPSVARHRNADNQPMVTAEVRTERTKKQNVCANFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-03-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTR2</accession>
    <name>L7JTR2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994069">
        <property type="protein sequence ID" value="ELQ74142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2940"/>
    <dbReference type="HOGENOM" id="CLU_594728_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTR2"/>
    <dbReference type="OMA" id="RDENEFC"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979132" evidence="1">
        <location>
            <begin position="29"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="460" mass="53771" checksum="22EDB7AADB68C0DA" modified="2013-03-06" version="1">MIRLQRKSLLKSQLILFLSSVFNMDSDGRVEPSFEIRVNKEEKQVDDHGLSYFYRDENEFCGDTVLNEKVIIGKNIQKGYKPNPTDYNESFSSEGDAKDKRKNNYKQIRFLSNNINGYMNDKDDFLSQNKKLRKAESNKSYKFSYMDNQTDKEKLCLEDISLVLKDEYLHQMNFYVKNKFLEPDDVIITPELVIAIVDTFAYNLKDNYKQDNEKSIVQDAENYLKCSLTLCFYWDSSIHAIFKICGDILNEATKSYGYNAIKTDDYKYTLVFKVFCTTLESIYEEVDGICDKLTHEILILLSSLSEQYNNDPKEIKQPINDNIQYILLFHLEVCRALRKNLMKVQRRLRITSILVSSRETKKKQKEVTNLDEYSISNVVIKHQKHELPSMNSNYSNKFQIFEELGNNLSTIKFSTSIENDQIAELVFRLNDLILQINVANQKLSILSNVPRQTKASEQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTV2</accession>
    <name>L7JTV2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.15</ecNumber>
            <ecNumber evidence="3">3.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="3"/>
    <dbReference type="EC" id="3.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTV2"/>
    <dbReference type="FunCoup" id="L7JTV2">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2581"/>
    <dbReference type="HOGENOM" id="CLU_082080_1_0_1"/>
    <dbReference type="InParanoid" id="L7JTV2"/>
    <dbReference type="OMA" id="QWDCVFI"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="20762" checksum="70AFF372D6231F58" modified="2013-03-06" version="1">MKIYFVTSSLSKFEEMRTLLPINIYHLKLKIDEVQGTSEDIINYKINFAKRKGGLDEVALLVDDTCLALDGLHGFPGVYVKDFLKIGTDNIEDIVQKVGRNATASCHLALYCNNKVKTFSGHVKGQIVPHRGGRQFGFDSIFQVDGNKTFSEMTMDEKNQVSHRGMACKAMVEYLKTGNLLCVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTY1</accession>
    <name>L7JTY1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ74760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2321"/>
    <dbReference type="HOGENOM" id="CLU_3368786_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTY1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="4389" checksum="A6B484F3AF7DDF32" modified="2013-03-06" version="1">MLPVLKTVKRLEVYFYQDSQEQIVLWLEKENMFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTZ7</accession>
    <name>L7JTZ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2304"/>
    <dbReference type="HOGENOM" id="CLU_1820511_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTZ7"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="16176" checksum="8243B6E4871D8555" modified="2013-03-06" version="1" fragment="single">VQFERPQWSHNAARHAIYFRPAVILAEFAHELESSQQKISDWCGRWRMSLSIGKCGTMVFGPKEVHGICFKELPFPTIDSYTYLGLPLTPNLDLNVVIRDEKEKAVRAHRGMRPFLTMKSVPATIKMQLVKSVLLPISTYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU06</accession>
    <name>L7JU06_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-type ATPase (P-ATPase) Superfamily</fullName>
            <ecNumber evidence="12">3.6.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.6" evidence="12"/>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU06"/>
    <dbReference type="FunCoup" id="L7JU06">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2150"/>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="InParanoid" id="L7JU06"/>
    <dbReference type="OMA" id="RMMESIS"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="782" mass="87290" checksum="8C617341FB71AD2F" modified="2013-03-06" version="1" fragment="single">VHKIDRYTFDDKSVIAMVIETGFGTQQGKLIRKMMTNTPPDNTEAYMFLLFLLIFAVLSSIIVLYQSIKMGKSNYKIMLEIILILTNVVPPELPLELTIAVNAAVHKLLSQGVFCLEPFRIVRAGVLDVACFDKTGTLTESEMVVHSIVAHDEHGVAGILSTCHSLLEDEQRRVVGDPLEMSAFTYVNAQMVDECTIRTAGMQYDIKKRFYFSSALRRMCVVYREGKKRVYRVGMKGAPETVRKFLARVPEQYDEYRRYAAEGYRVLALAGKHLLSFTESTTRESVEKDLVFVGFVLYKSKVKEESRAVVDALKGAGCAVVMITGDNALTAVAVAKCLGIYNGGVMEGDEISVALDEWEGSIGRDIGRDVEGGSIGRDVSAGRDGSVVRDTKDRNINKEINNKDKEINHSINNNINRRDINRDKEINPNTNNNDTSNENTVIERFSDMESTDRIGGARGGRALMDVSVFARADPKHKERLIRFYKAKGLVTLMCGDGTNDVGALNEADVGVALLVNEQKKAQPESLREALLSELMDKKVNLGDACVAAPFTIRNGLLSGVLSVVRQGRSTLVTTFQMYKILALNSLITAYSLSFLDSIGIRFNDYQITISGILLAFAFMFLTRCEPLEHISAQRPLTGIFNTYFMTSIMSQTAIHIISTFILVMYIGTPSHYNEKFVPTTLNSSLFILSTSQQVSTFIVNYIGRPFRESFMENAHLRNSLFVCLGFCVFVLFEVNLEMNRALEIVELGDVRMVVMGLMVADWACCYLVERCCARLWGSRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU18</accession>
    <name>L7JU18_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2839"/>
    <dbReference type="HOGENOM" id="CLU_164198_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU18"/>
    <dbReference type="OMA" id="TCERCTN"/>
    <dbReference type="OrthoDB" id="10272010at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="Zn_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon 15" evidence="1">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="101" mass="11732" checksum="875371FBB286A31F" modified="2013-03-06" version="1">MCELRFCGTKRKTKRTENQDTNDIFCPYCACSTKSVWLIDTMYFTFCFLPLYTIYNSSEYIGCKNCYKKLGDRSVKTCERCTNVIIAGYRYCGRCGQAVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU72</accession>
    <name>L7JU72_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU72"/>
    <dbReference type="STRING" id="72359.L7JU72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2008"/>
    <dbReference type="HOGENOM" id="CLU_106415_2_0_1"/>
    <dbReference type="InParanoid" id="L7JU72"/>
    <dbReference type="OMA" id="NWITIAS"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="4">
        <location>
            <begin position="122"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="202" mass="23953" checksum="42A305D78935CE21" modified="2013-03-06" version="1" fragment="single">VFITYFYHYNVIESSMVRCKSLQKRSLNLINHRTKYRFNFSHVLITNTKHTFLFSLKFWSLSEMERENDALTAIKEKMKDAVFRDKELNRHGKPALNRLDNLDGCIRALYSLRNDIDTETFLILKEWLEPLPDNTLPNIEIKSEILSFLLKTSVTRDQLVESEIGKIVYFYSLNNHETSEIRNLSKQLVKKWTMVAVQEQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU81</accession>
    <name>L7JU81_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994000">
        <property type="protein sequence ID" value="ELQ74979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2077"/>
    <dbReference type="HOGENOM" id="CLU_3144012_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU81"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="6034" checksum="D638E18F2CBA767D" modified="2013-03-06" version="1">MNICFYRTNDDRINCSHVDEMQLYAYLKIVYFCFERNDSISSIYYTDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUA8</accession>
    <name>L7JUA8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative WD40/YVTN repeat-like-containing domain, WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUA8"/>
    <dbReference type="STRING" id="72359.L7JUA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1992"/>
    <dbReference type="HOGENOM" id="CLU_022997_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUA8"/>
    <dbReference type="OMA" id="MIKECIR"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="811" mass="93030" checksum="CD0CA8DA9016971C" modified="2013-03-06" version="1">MAFILTNIIPTLSTSKGIVQHRNTLYFSSSNSIYILNKHSCSFVVSLHGEIKDLQSNGIFIFAQTSERLYMLNGSKILATMKMNGVFTVTDTHLIVGECELFLYELPVKYSMIMFKRVGDIRAHNESVLRVKMLENGIVLSVGRDSTVRMSSFRDGRSRVLCYHRELPVDVFFYEDLFENIDDENDRVNETENCEKNQNENDKDEKNIYKTSKYDENDKNAHAISFVNNAAAERGKAGNSQDILDTLSKDYFIVTVSERGTINTFSTKKRKIVKRTFLDRNVRHACRKGDQLFLLTDENVVLVIKDDDIRECSVDINAYEMQVLDDMIVLRGASNIAVYEYLRPVAGIGQFIKNEKIQKVNSLTPNLLQNNESEQKESLCCLYSVPLCKIVDFSENNDIMLSCADNTVHRANLINNTCYFGDSTTDIFNVDEPVYQIFYKCNVLVCITETCLVKAYDVRKGTLFREINLGFKVSCADSNEDNSVLFVCNYDSYEINIVDIKRSKVVDTLKLSAMIRKLCYFNNSVYFLSMDNQLVRYFFMNGQMENFEMKKTIYDFEISNNNVVVSLEKEIVVTDGSFNILRSFNLKFVSRNRNEMFISSKPCTSCSLTYDGTTLVCGAQANEIKIVDLETGCVIQTLKLSRNKEKENYKKRLGVEKKDEFKHVDVIEAMKIKYMPNGFLVLTRESVFLFKVKSVEVERGAFLRKMDENEIKESLKEHRFVRALLGSINLKSKIMIKECIRETRADVVDDIVKNVRKEDVTYLKGVINEVILAGNTTYQGMVWLKALVYNFTGHLVESDLEVIKMLKAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUC8</accession>
    <name>L7JUC8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993994">
        <property type="protein sequence ID" value="ELQ75083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1979"/>
    <dbReference type="HOGENOM" id="CLU_941852_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUC8"/>
    <dbReference type="OMA" id="DNLMRIN"/>
    <dbReference type="OrthoDB" id="2191243at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="296" mass="34488" checksum="39D4285BCAE77D2C" modified="2013-03-06" version="1" fragment="single">VMSARTSADDSVKKFVINDNSNDTSDTDKPSEILQLNLVPGTLYINVSGIIGKYGNHPKLESFYVVLKNKEGVVGVEEVKKEYGKAFDVFFKLNIVDNCQLKLILYLKYKNMSFDYRQSSNSKALDKNLKKYGECTVECDKDEIKKWHNGVHFVDYALKKHSEPNIIKRFLELFEPDPPEIYGLKAHVSYIALEEQKMIQVRTISNLSDLKEWLRFRQNTYKKFFHGYVNLKGHGLEHCTHLWKRRYIEWNGYKINIFNVYTSEKIGTVDISNASVQCVDVESKNFLKDNLMRINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUE3</accession>
    <name>L7JUE3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2735"/>
    <dbReference type="HOGENOM" id="CLU_1603909_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUE3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="166" mass="18885" checksum="B5BD435108D0E3AF" modified="2013-03-06" version="1">MRTSRFYFFIFTALPMLLIVATLILGLLIALALLIRCKKRKRILITGTKGVGKTVLTNQLMNRTFPTVPSLCDYTVVTPEYELTDQRIKKGVKLRNGYDLIVFVFRDEIETVLPGKNVIYVSLGKEGKSLADLVTDKDKKYFVKRGNVFYLNDDLSKIKSIISARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUF9</accession>
    <name>L7JUF9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUF9"/>
    <dbReference type="FunCoup" id="L7JUF9">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2690"/>
    <dbReference type="HOGENOM" id="CLU_325458_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUF9"/>
    <dbReference type="OMA" id="CTIVKAP"/>
    <dbReference type="OrthoDB" id="2187858at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="1">
        <location>
            <begin position="632"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="886" mass="102077" checksum="CA10FFB9274333C4" modified="2013-03-06" version="1">MKQRYNYLDIRTAVNELHPKIESTYIQNIYSSGQRTFYLRTNKNIFLIEAGLRIHLTNTYPSDEISFFAKRLRTYLRRKKVGGVRQVGFDRAVVVQIGEFLVVIEMFSAGNLIVLEKESVADENECEEENGARNKLSAEDLNAFEMSKQGDAVVNIEKRTDVDKKTNKKLSNRTGEELPKKESKVKKKLRESIVKGLKVHKNGDRERIDLNDIYNLKNKYKIVDIFRPVAELNMIKGSYYVFNPIQLNFKYSFFQNVDTFIGLDKEINEFIENLLKVRIGMARRGRKLNNISKNCITDPLVSDKTAKHLSSDEKTLQTTAFKEYMKQIDLKSLDDHDIVVFDAFFDNLKKVFEENKDYGAIIEKKGKATNYICLDFHKIDLTGEFLACYPLNLRTFGSFNDCVNSFYASSKKVQKKVNLSKREKVREQQLKYIQEIDNEENELRKSAIIIGMARDDINKIFKVLNYVKNNKISWELFFKQKAEEKDPLNRDSILKVDFIKNEVLVRIFYDRGVFDENDEHGPVGTEQKNDNEYDNKNSKKIAIDHSKNSFEKDKPTKEGVGVSKRCYKDILLFYKLSIDKNMNYYYNQMKNKKIKREKIRNNLESILANIVEKKAVVKPQEIKKRVLFWFEKFNFTITSNGFLVLGGKNASQNEVLNKRKFLLFFHADIKGGSAVTIDGTRINILGRCAKHESSSETSIKRIVASSDNAYGLKEEDITDASQMCMVYSNCWKDRIVSDSYYVNEDQVSKSAPSGEFLSKGGFMVKGKKNYVHNVRLEYAIALLFALEKNLEQQIENMHVGGDKNHEQKNISGDVNKQNLINDNTADLNGENSVKTSTVTANQDMQMVFTASPAETDGISFAFPIAGSWDTLKTYKFAIKIVPSRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUI2</accession>
    <name>L7JUI2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994001">
        <property type="protein sequence ID" value="ELQ74975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2086"/>
    <dbReference type="HOGENOM" id="CLU_2499467_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUI2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="86" mass="10061" checksum="228EA798DA3D5413" modified="2013-03-06" version="1">MVIGERYVYETNLVLDYLRMFTARCHATLTGPITSRDKFTVMMVMEAILVECYIKDTERGNMLSNGRSATFEKTHECRDDPFVRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUJ0</accession>
    <name>L7JUJ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide excision repair complex XPC-HR23B, subunit XPC/DPB11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:XPC complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
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        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
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    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="1">
        <location>
            <begin position="188"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="347" mass="40979" checksum="5993295A677E8618" modified="2013-03-06" version="1">MTSSDGWHSVSSEKDELFNENKTKKIRVSHNKIRIALFIKLLKILKAIVARMKYVPTETNKFLEYRRLCASESDKIFIFKKLVFLGIPCKLYVIINDELEFALEVFMMEIIEKFKLSKTGLIFYIGVDGSLVNTTLLNSTKFKYFSIFASLIFEMKDILYDHSFFRESRKRLIEQGVTLPMNFNENAIFSAIPRSLKNMKYHPLYVIESIIKKNQIIFPKRPILGYFKGEPIFCRKNIQTLRSEKEWFKLGKKVVKPIYKLVDGVKLYRKYDVEDLIIMDLEDKPMLYYHDNHVPKNCVYSKNELSVLVARLLDIRYSECIVGFRYKMPIFQGIFLLKEDALLFLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUN0</accession>
    <name>L7JUN0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUN0"/>
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    <dbReference type="HOGENOM" id="CLU_1111999_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUN0"/>
    <dbReference type="OMA" id="VESEGAW"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="250" mass="29173" checksum="90719DB961D9F8C1" modified="2013-03-06" version="1">MINTLSTDSVVELTCKDVRDDLIQQDIPRGMHWGGFRDRIGCNNWRDCNNKIDCKDRIGCNTWIGSNNWRDCKDRREGGCKEPFNRFNKFNTFNTNTLNYPEIFNGNATQKGVPSDQHLQLRSLAQHYHTLHTTMTQLSAAHIKNKPLNNYYTDKAQHYKQCSLSLHKQAVIRLMAHKIRGNRIDLHDLYVWEGLMVLDDYVRVYGLNRFYVCVGRMEKSLRMRPEVIKYLGVRGFVVESEGAWLRVSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUN4</accession>
    <name>L7JUN4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RCC1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUN4"/>
    <dbReference type="FunCoup" id="L7JUN4">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1894"/>
    <dbReference type="HOGENOM" id="CLU_005210_6_2_1"/>
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    <dbReference type="OMA" id="IFVWGTG"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="211"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="308"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="356" mass="38390" checksum="ABBB931CC40B7453" modified="2013-03-06" version="1">MPVYTFGSNLLSQLGTGDEPGSSSTPLELPAFTDLKVDKACCGSLHTLILAEGSVYSFGCNDEFALGREGDENVPIRVQLPERITHIGAGQSASFCIGSSGKLYGWGTFRDKGGVIGFKPNKKFQKVPVVLHRGPVRQLAVGSNHVLYNVRGEVYAIGANEFGEKGVHRNTRMARCRELGAVLVANRRSMFSKCGRMFCGAGTSFMVSERGDAFAFGQNANAQLGLGNTHGGISKRKVPLDDVQSISSGELHTLFVTRNNALYAVGHNMFGQLGTGDNADRHVLTRIDLPNVRTASTKGFFSVAYTDDGMYSWGFNSHGECGYAGQDSSAPKRMETQFDDVVCFDVGHDFCVVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUS7</accession>
    <name>L7JUS7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2268"/>
    <dbReference type="HOGENOM" id="CLU_2694754_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUS7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="74" mass="8445" checksum="65CC1FA8BB9DAAD4" modified="2013-03-06" version="1" fragment="single">VKIYENCYELLKIEEEDIKQKHERLSDNSLNIKYSSVSKNITTIKQIENCNSTPENESDSELVPELSVTDPNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUW1</accession>
    <name>L7JUW1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993977">
        <property type="protein sequence ID" value="ELQ75258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUW1"/>
    <dbReference type="FunCoup" id="L7JUW1">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1806"/>
    <dbReference type="HOGENOM" id="CLU_035750_7_3_1"/>
    <dbReference type="InParanoid" id="L7JUW1"/>
    <dbReference type="OMA" id="IQIEMAH"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="251" mass="28298" checksum="BD70D7DF74D64F46" modified="2013-03-06" version="1">MCFFSKYFNPKTFCPLMPSTNIQDMFFDKEALRNDVDYQKINDMVKPFKGTTTLAFIFKEGIAIAVDSRATSGSYIASRTVHKVIRVNNYLLTTMAGGAADCLYWEKRMGAFAKLYEVTNGKRLPVPAAVNYLRNCIVGRRGLSIGTMVCGWDDKGPNIYYLDNDGTMVKGTVFSVGSGSTIAYGLLNSNYRYDMSRDEGLKLARDAIFYATYRDAYSGGFVNLYFMDNNGWQHVGQYDVNGLYEELIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUY4</accession>
    <name>L7JUY4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUY4"/>
    <dbReference type="FunCoup" id="L7JUY4">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1780"/>
    <dbReference type="HOGENOM" id="CLU_070952_2_1_1"/>
    <dbReference type="InParanoid" id="L7JUY4"/>
    <dbReference type="OMA" id="IMGINRN"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="193" mass="22641" checksum="042628DD97FE03FA" modified="2013-03-06" version="1">MQQYFPQPSKKAYRDRTFSGTDEQYEKLLSTTCTLYIGNLPLSTTEERLWTVFADLPIRRIIMGLNRNNLLFCGFAFVEFYNHVDCRKACVASANMMIDGRSVWVDMDYGFTEGRQWGRGFAGGSFKADMRKRGRVRTGNGRYYDSVKRGPDDLRQRPHARNVKNAEPFEERKRKADEEGRGQYYDEGKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV04</accession>
    <name>L7JV04_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exosomal 3'-5' exoribonuclease complex, subunit Rrp46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV04"/>
    <dbReference type="STRING" id="72359.L7JV04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2506"/>
    <dbReference type="HOGENOM" id="CLU_123986_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV04"/>
    <dbReference type="OMA" id="RDIMRFR"/>
    <dbReference type="OrthoDB" id="2191718at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="20431" checksum="839989E146D8F9A6" modified="2013-03-06" version="1">MDKSIDCSVGFMKNAMGSSSFQGMNTTVYCHVNVLPDVPSCISTLPYIEVHWNEGSSRSLNTYFAGVVEQIFSKIVKDDFRRVFVLELWVGVGVRNALMCAFNAAVLALVDAGVPLRKMVYAANFDEQTEGMVLFENDRPVFVHSFGGIKESDIEIAESKLSEIRDIMRFRLENKYNFNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV27</accession>
    <name>L7JV27_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1719"/>
    <dbReference type="HOGENOM" id="CLU_1050483_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV27"/>
    <dbReference type="OMA" id="NAGKSCK"/>
    <dbReference type="OrthoDB" id="10488502at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="265" mass="30359" checksum="A876ABC53B301F97" modified="2013-03-06" version="1">MLRLNPETNKSFEMNSKDKKKRDLLWKNIAEKVDEVDDPSVAQTMFSYFMKSFNKKMKEANAGKSCKKWIYYDLAKKYMPDLVASAEQTAREIENKNSAEKVLSGSCSANNNEKSNMTNIVQAESDANVPLTSRSAKESVEEHEIAKNDTMKLELEKKADNVFEFGKNLSVSPQKHDEKETNIDMPKKRLKVHKDAALKFSDPSDVKILDLINERDMLVKRLLITDNNDEKLIRKIAAKDNAIQDLLGDRKERMALVSLIREKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV39</accession>
    <name>L7JV39_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GATA-4/5/6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV39"/>
    <dbReference type="STRING" id="72359.L7JV39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2157"/>
    <dbReference type="HOGENOM" id="CLU_590770_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV39"/>
    <dbReference type="OMA" id="FWRRGIN"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="463" mass="54562" checksum="8EF89A0CF498AC9F" modified="2013-03-06" version="1">MYQTLLRKQKEREGKKMNKEKINEDKKKDEIEAESKNMEDEYARKTEYPAYGKEEFVDKRNYANYGYETNYNNVYTGYSPKIPVYKKFGQETYEDPYFQYNHNKFQGYDDYYTLRMNMRMHKDSKRKPKMRVCSNCVTTTTPSWRRSTDGKKLLCNACGLYQKLHGRPRPYSTTPEGKTKALKSGFDKIKCGNCGTTETSFWRRGINGHPLCNSCGLYFRDNTYKEKEKEMSHDANFASYADAYKDGGFKEKEMLRDPAFAPYTDMYKDDAYRNREMARDGAYVTYPNTYKEGGYKDKEMMHGEAFTAYTDAYKDGGYKEKDGVFPGYTDNGFKEKFDETVPDKYNEGYADGHVSDNFAFSKYKTKFSDDKRHADITETSPYMKKVDPTHDYRYDQKYQKADYYKNYDGPYQYAQYETGNNNFAAYDGEDDYGYREYKRGEEEKRGDGLGVANKYSETHKRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV54</accession>
    <name>L7JV54_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2426"/>
    <dbReference type="HOGENOM" id="CLU_3108111_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV54"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="51" mass="5683" checksum="978A4E79D8F9DBEA" modified="2013-03-06" version="1">MKMPLNRHETEEAKIEKAISGEAVKNDQILAKESEIASLLRMSRENGNGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV63</accession>
    <name>L7JV63_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993972">
        <property type="protein sequence ID" value="ELQ75314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1741"/>
    <dbReference type="HOGENOM" id="CLU_1908168_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV63"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="133" mass="15018" checksum="6234566A5E69187D" modified="2013-03-06" version="1">MQRMRQIPREGKHEGINLAEGSDNGKGLKRLEVTLSSLFVPVLVSFQGNSRYFTRYEKAIHPESFDGKGKMMTYSLLVLYARFEDVTDLRLVSFVKLDITVTVGIVWELSAQSNALYVCSELARRLTSCGHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV83</accession>
    <name>L7JV83_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV83"/>
    <dbReference type="STRING" id="72359.L7JV83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2093"/>
    <dbReference type="HOGENOM" id="CLU_501718_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV83"/>
    <dbReference type="OMA" id="NFFRLAM"/>
    <dbReference type="OrthoDB" id="10543398at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="543" mass="61508" checksum="D3D98A51B15512B2" modified="2013-03-06" version="1">MSNKEKNKNKEKSRSRSTTKITNSTTKSNTSINKHKNNHQTHPKHPKTTPTPRKRTPPPLPHLTATESLIAQHGTIKDYLDLLTLKYLKTGDAVFVNELIECASVQRNDNIYYALCNLADIVNDREDGNGRNNREDGNGSNGRKGDNDKSSNSSIDKNSNSSIDKNSNSSIDKSSNSSNVTNDTNTNITNTNTNITNTNTNTNTNTNITNFFRLAMKNTFIASKSTLITASILPKMPALLIPFILKLRNKDTYRVVTDALLGMRYDRTVDHELMDMFFKEDDWLVRMRIVYVMVGRCADEEIMMIYKFMVGVNERYGLSYDYGCDRDGNRDDGCSGSTIAGDTTSRDSRSNTPLNNRPTTSRDIRSNTSLNTRHTTSRDIRSNTSRYSRSNTPLNTKINDQLKPRDKTLITKINDMLINHLSKTTPTLPINQSPSTHNFPKLLALSSNKHNLINTYLNECIPSAHNLSLILDYVLESRDGKILVRVIECGLDDEGVRCFVERMRDVVVEKDVLYYVVGMKRHWDESVRRCVDGILKDRMGKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVB3</accession>
    <name>L7JVB3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LRR containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1622"/>
    <dbReference type="HOGENOM" id="CLU_033135_1_0_1"/>
    <dbReference type="InParanoid" id="L7JVB3"/>
    <dbReference type="OMA" id="ERNEGME"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978786" description="LRR containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="79932" checksum="64250657EF221F0C" modified="2013-03-06" version="1">MFWFSNFLSVFQLFLKISGILTNESERGAHTSGHYTEVQDYLVTSTAQKSHNERIKMMKRILESKTIINSKELEKTNELSTSPSKYLEDERLVYETKDYDFYFSSQRVNSTEPSGGLVIFIRDETISDAKYIFENTKNLYLTIYIHVERAKVLDFCSFESIFHCITGLCIEYHGSIEAGKLLSVEYVIPNLNFDEFNQLKTLKLINMLIPGKLLKELAEDTQMENLNFKNCHFYSNEYTAEQSLVLNVEFNKLYKIICFDMCKDDMARGKPILRSQRYYDQINVSVQKCENLCKLHLNTPDYVRIVCNEKNLYRLQELSLYIIGGEPSFMFSPGLSAKLKYLSIIIRKENIEAYQTLMMIDRSEIEHLVLIYSTDEPCLYLSEIFGLSFDALETLKIEASNYNLDLCKIDCNLSMRNVKALIIHCWTIKSGFIRVVNRLESLRTFNVKLSSDSYKNCKRFLRELNLKHSLEKLFIDLVIPIEKIEKSLMSFKNLQLFGTKNIFGCRPAKKPNHRNRTNIISSVKPSPHPIKNECIRILPCKILHLRMFLFSSIVYYEESDVWKAFAEVEVIIIEGYELAEFNTYLTEEDFIKQLPMILRSFDQLDNIVFQKYRYLKTLIIDCENENRSRKLIDELSRMYTKKSRTFFKYYYWVKKYNEERIFLKIRRCTTRLSQGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVD0</accession>
    <name>L7JVD0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">MFS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1681</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>A new family of cell surface located purine transporters in Microsporidia and related fungal endoparasites.</title>
            <authorList>
                <person name="Major P."/>
                <person name="Sendra K.M."/>
                <person name="Dean P."/>
                <person name="Williams T.A."/>
                <person name="Watson A.K."/>
                <person name="Thwaites D.T."/>
                <person name="Embley T.M."/>
                <person name="Hirt R.P."/>
            </authorList>
            <dbReference type="PubMed" id="31355745"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MH824668">
        <property type="protein sequence ID" value="QDQ29473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1681"/>
    <dbReference type="HOGENOM" id="CLU_612788_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVD0"/>
    <dbReference type="OMA" id="IVIYSSH"/>
    <dbReference type="OrthoDB" id="2191199at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="6"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QDQ29473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="447" mass="50563" checksum="83126A8DA7B77316" modified="2013-03-06" version="1">MDCRLLSLFMISFFLYASIYAVHNFMFQIVKETGVIDKKKYCLLQLLYIFKFAGVVIFCNLGDRKGIHRYLVAINVVLYSVSILALYNLSSIASLRLRKAFVILTIVSSYIFISGTFPLLDSLTYNYLEHEGLDVRQSGRVRMGGALGNMFVQVVCSLLQYCFSRRLRGEGTKNRENVINISCNLFFSAGTALIALLFAPNYVLGKKVIHAPKKAWKVKKIFTDLISLLNPLLVLYTLAVLGQGIDRAGISTFLSKYLENKGIERSYVHVLFFCRCIPEILIYGLSQQIESVLGMNTMFLLSVIISSSRSFFYSSYNFNNSPGTLKAITVIAEIFKGFYSSFFNYCGLRIFRSFATDDTLSLAQGIFNGTYNALSYFTFAFLGYFLVDYEKAGQPDADEDIRHLFFVVACISCVSIIAPIVAIVKRRLSRKEIHKNNELQPKPAEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVI0</accession>
    <name>L7JVI0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar H+-ATPase V1 sector, subunit B</fullName>
            <ecNumber evidence="7">3.6.3.14</ecNumber>
            <ecNumber evidence="7">3.6.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="7"/>
    <dbReference type="EC" id="3.6.3.6" evidence="7"/>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVI0"/>
    <dbReference type="FunCoup" id="L7JVI0">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1747"/>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVI0"/>
    <dbReference type="OMA" id="KDHGNVS"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902906">
        <property type="term" value="P:proteasome storage granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="6">
        <location>
            <begin position="220"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="37682" checksum="B4935281D21873B9" modified="2013-03-06" version="1" fragment="single">VAKKFLFLAGSGLPHNDVAAQICRQAGLVKKKTVIDTSDENFAIVFAAMGVNMETARFFKSSFELSGALERTALFLNLANDPTIERIITPKLALTAAEYLAYETEKHVLVILTDMSSYADALREVSAAREEVPGRRGYPGCMYTDLSMLYERAGRIDGKNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYIDRQMHNRQIYPPINVLPSLSRLMKNAIGEGMTRNDHGDVSNQLYAKYAIGKDAQAMKAVVGEESLSAEDKLSIEFLERFEKEFIGQRHDECRTIDESLDIAWELLKIFPRDMLNRIPENILNQYHSVEEKTVEKDINLEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVL6</accession>
    <name>L7JVL6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
            <ecNumber evidence="5">1.1.1.62</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EC" id="1.1.1.62" evidence="5"/>
    <dbReference type="EMBL" id="JH993994">
        <property type="protein sequence ID" value="ELQ75086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVL6"/>
    <dbReference type="FunCoup" id="L7JVL6">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1982"/>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="InParanoid" id="L7JVL6"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="322" mass="37091" checksum="16836B04F9FE040E" modified="2013-03-06" version="1" fragment="single">VLLIVKDVYAVLMIIGTYFFMSSFLIGKKICPGMLFTIFKIFVLFLCFQVIYLNFRFVASRILNYRVWKNIKGRWIMITGATDGIGKEMALILAKMRQNIIIVGRNAEKLAATQAEISKLTQCKSILMDFAVEQSFDDVITDNIGMLINNAGVSSEYTKDFVDEERITQIINVNNLNAIKLTQSVLKKMDKYSYIINIGSKVADFPCPLHVVYAASKRMLKSWSVSLAYELNHRYIHVEYISPHFVATKMSKIRKSNLFVPSAHDFAKSVVESVGTWWENTPYFYHVVQNLFLMFIPEILIGYAVYFKHSHIQKLALRKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVW1</accession>
    <name>L7JVW1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1429"/>
    <dbReference type="HOGENOM" id="CLU_2374265_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVW1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="95" mass="10901" checksum="FC6C6F988B4FBA5B" modified="2013-03-06" version="1">MTVRLLSVDRRALDNFWHTNLVNSALLSWKAVVVNPAIYCYRALIIKIYIRHSLCPVRYGAVAWFARENVRFVRKRGGKPHGIACEDLKDGLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVW4</accession>
    <name>L7JVW4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1596"/>
    <dbReference type="HOGENOM" id="CLU_3112250_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVW4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="51" mass="6129" checksum="50D613BC0C4DE3BA" modified="2013-03-06" version="1" fragment="single">VRNKTLKMFLENEDIQVLQNQMDDSMRNLRFKLKEAIFVTLESSNNLKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW01</accession>
    <name>L7JW01_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_1535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW01"/>
    <dbReference type="FunCoup" id="L7JW01">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1535"/>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="InParanoid" id="L7JW01"/>
    <dbReference type="OMA" id="NPMKELK"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="12">
        <location>
            <begin position="85"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ75495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="22147" checksum="9D70BEC7118201E7" modified="2013-03-06" version="1" fragment="single">VSSCDGPVRPPSALKIFKILPFSMTKTNPMEEVRIHKLSINLCVGESGDKLNKAAKVLEQLTGQKPRFSKSRLTIRTFGIRRNEKIAVHVTVRGEKAKDILNNALKICEFELRETSFSETGTFGFGIKEHIDLGLKYDPAIGIYGMDFIVVLSKPGLRVCKRKRLRSKVGNKQRVSKEEAKKWFVDTFEGVLVPANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW31</accession>
    <name>L7JW31_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1410"/>
    <dbReference type="HOGENOM" id="CLU_2607715_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW31"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="8888" checksum="4CF82D6B76D2CEBD" modified="2013-03-06" version="1">MNIEDLQNGATPQTYANKMITTEDISSYGSLIRTNILFIANPLVGITILVILALVFVYNRCIKPKLDGQKQIQVEDEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW41</accession>
    <name>L7JW41_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994001">
        <property type="protein sequence ID" value="ELQ74977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2088"/>
    <dbReference type="HOGENOM" id="CLU_2499468_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW41"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="86" mass="9984" checksum="9982CB1FB86D3AC2" modified="2013-03-06" version="1">MHVIVSFSYSLSARQRVEVSLQIEILFKNNLQVVCQLICNELQREIRIAALDRPLSVDVKKVSAQEYITYLLAMMRYVFFGSNTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW78</accession>
    <name>L7JW78_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of nuclear mRNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW78"/>
    <dbReference type="STRING" id="72359.L7JW78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1326"/>
    <dbReference type="HOGENOM" id="CLU_136889_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW78"/>
    <dbReference type="OMA" id="HKLNIFY"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="168" mass="19656" checksum="5E05B17897850F0D" modified="2013-03-06" version="1">MSLFSQETFIKEIRTLSPTQEKIKTLALYMKTTSTESTRMLRILDQEYAKSNAYHKLNIFYLANELIQTIKNDEKDLALLHEQIKSFVVSNFDDAYAEMSKYPVLKGKLMELKGVWVERKLFGDAELADGALPYTYGREEVIRKIEEYFDCREALAEYLDGMVKNLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWA0</accession>
    <name>L7JWA0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromatin remodeling protein, contains PHD Zn-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWA0"/>
    <dbReference type="STRING" id="72359.L7JWA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2012"/>
    <dbReference type="HOGENOM" id="CLU_031900_4_1_1"/>
    <dbReference type="InParanoid" id="L7JWA0"/>
    <dbReference type="OMA" id="SAFGDMI"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="22989" checksum="7FD2537AEBD9D3BE" modified="2013-03-06" version="1" fragment="single">VLKNNFLVSDPMTNPFELFDKLLNDVHLYPLDAQHQLVTIQDIDNKIVNYTRKLHKYFKGSLKLSRKTYNKQIKKCLASISHLNRKRKAAMSIIMECTREIYADMQKEYPEELKSSIGDPSKNPSVFKTRVSKEDVNNNIKQPKYCLCRASAFGDMIRCDDPGCKVLWYHFECVGLVHTPKGNWYCSTCKKNRTKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWH1</accession>
    <name>L7JWH1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1292"/>
    <dbReference type="HOGENOM" id="CLU_2856131_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWH1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="8009" checksum="08D488AEF5CBBA0C" modified="2013-03-06" version="1" fragment="single">VKWLMEVFVFDVNRQWRNTRSKYNGDRRQYKKENASKYTYNKNVKSTSGLDNIKKWMQREKKSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWI5</accession>
    <name>L7JWI5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <ecNumber evidence="2">6.1.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JWI5">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1210"/>
    <dbReference type="HOGENOM" id="CLU_444948_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWI5"/>
    <dbReference type="OMA" id="LHQNICX"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="1">
        <location>
            <begin position="334"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="614" mass="69513" checksum="F26AB1EE30F1A37D" modified="2013-03-06" version="1">MPAITINKQLFLSSLKNTYTLSSLTELLFTYGIELEDTITENGTQYYKLDIPANRYDLLCLEGMITAMQCYEANTRAHWPVIHASTHRVIVMNTTERPVVACAVVRNVQFDEDVLRSFVNYQDSLNRNVGRNRRCVAIGTHDYDKIRFPVYYRLGEKDRLWITPLNGKGVCSGGSGVMTNEKNYNENYKEENEEENKEDLTRDENINGGASQGTATFPKITIAALEERLKNDRVFSKYITSCTSTAYFVDSNGVIISYPPVLNSDETKITVNTKNVFIEMTGDDRAKVDDTMRYLIHNFGGERVEEVHIVHEDEKEKGRVVDKKYAGTHVTPVMDRKMFTLTREHVNKELRLNLTREMIKYHLERMMHHVSLEESDMRVTVHPARCDVLHTIDLIEDIAVSYNVNNFDRLNVPFFSIGKELIANVLSDKIRMECAFAGFNEVVSVCLLSREENDVLRRGDEELLMGGYDETVDGGCEDVGDCECSDGAEDVVGVDDEFGGVDKRGPVLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWJ9</accession>
    <name>L7JWJ9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWJ9"/>
    <dbReference type="FunCoup" id="L7JWJ9">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1956"/>
    <dbReference type="HOGENOM" id="CLU_014813_4_0_1"/>
    <dbReference type="InParanoid" id="L7JWJ9"/>
    <dbReference type="OMA" id="KDGCICA"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="387"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="439"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="559" mass="62291" checksum="6853170A3F33C26D" modified="2013-03-06" version="1">MFNIILYLSIVAGYLNEKPEGDKKYRKIAVTTEVPLCSDLGAEMIRMGGNAVDAAVASAICVGIINSFSSGLGGGGFMLIKLPGNQNEVVTVDFRETAPWKVNVDDYKTKKDMSKKGGRAIGVPGEIKGLYHTHLKYGKLPWKFLLEKNAEIAENFEVSDQLHRRLKKLKKYIFRDPGLSSIYIRNGDLVQPGDMIQRKNYAQTLRTLALDPESFYRGAIARQIVAAVQSQGGRLSMQDMIKYEIKTPKPLQSTYKDNLVFTTNLPTAGPLLIEALNILESFDLKELQGIGTEHGIFPEYHLLVEIFKFMSAKRGELGDPAFVPEAQEIAERLISKEHAKKVSETIKFDRTLSIQEYGYENAFTEDHGTTHLNAYDEQGMMVLLTSTINLEFGAKYMDLVTGIIFNNEIDDFYVPFVKNAFDLPESQANIIKPGKRPFSSAAPLLLIKPNQILALGAAGGTRIPTSIISTIFHLELGKTLSEAVAEPRLHHQMIPYVTYIEYNLNHDVVNYLAKIGNEIKESSTNSIFTSVQGMIVRKNPEIEIEAYSDKRKGGDTAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWK5</accession>
    <name>L7JWK5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1265"/>
    <dbReference type="HOGENOM" id="CLU_2177191_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWK5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="12519" checksum="1F468CD046FA0E6A" modified="2013-03-06" version="1" fragment="single">VQRHGQKSNLVKDGFRRRHTLTNDDINDNSDPNKINCVVHDNSELTCEPMPKIHISTRAKNEYNIDVSCPKEGNSISKCSLSVLSPANNDLNIVGFWNGLWYYKWGKFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWN0</accession>
    <name>L7JWN0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993907">
        <property type="protein sequence ID" value="ELQ75888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1152"/>
    <dbReference type="HOGENOM" id="CLU_260521_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWN0"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF22">
        <property type="entry name" value="PROTEIN DBF4 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1313" mass="148889" checksum="D63C80B4AB7ED7B3" modified="2013-03-06" version="1">MHKQTEEIKGSPYDPRIEPSNDENGGVNKRSSAEQERSINENDEEGMNASRLSREGIVLEDVLRDGKESVVKKDDKDVLRDNERINNPNNDNDNDDNNNPNNDTNNNNNPNINDINPNNHPNINNNINNNSLSHSVSDVKLGGAQDTTTIKNDESDKSITLAELSMADSALPSHVNTTDMLNLITFLFTSTALQEQRGSVHALHILLMLSINSDLFDNERLNGVVRILLELVNFQEALMCAVNYGNLFVSTGMPIDDSTGINDDGRSDGREGRSYGREGYDRSIGNGKDVNNLNNNINANLNNADSAKSIDAMIEQKLDSFYFNNGKPVKYVALERIDLNNDTLLMIVKHINPFNQEFWIRFVERSDLREVFFILRHVIKGRALEPCKRVLFERLFYGGDEKLFMAYEMCYERGFEELMIEEVQITKGDDNLDKVSGLDKVSGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNNNYNTNHNHNSNLNYNTNHSTPSNTNHSTPSNTNPPNLNYNNTCKKEQLCLKILKYSFNVLNTLTFYKTLNIISNRPIIPFFSTLSSSSLFNKIIEDRNIVLMHKLLHYNHKFIKHLRRGVNLFDTILGTHDTCAQLPRTSEHYVLVIDIIRQLLRMNLVPSINYRVLYGRAPLSFFYDTLELVEHVLENKETHSFFVECMPRCNVVFKVRNREFGKKFYLSVIGEYYGVCVEYSRVGVDGVVSRGKDGNLSRGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTNKITNKTAIDLPKLLDINTISDTQRLAINNVFLERTPRSSYFNLFFNECIANQKKIENVSHLYFLMSNMNRKAYTNRMVEMCLQYLYKAVQGRKKIGSNLMRVCLRGCGVPLSDRSRGYVCSVAFFLIKREQEVCLEVEGYNERYEDVMVRHYRGSERGDGRGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWT1</accession>
    <name>L7JWT1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome condensation complex Condensin, subunit D2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWT1"/>
    <dbReference type="STRING" id="72359.L7JWT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1283"/>
    <dbReference type="HOGENOM" id="CLU_649218_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWT1"/>
    <dbReference type="OMA" id="THHISER"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="423" mass="48705" checksum="0A88B98948A6FB98" modified="2013-03-06" version="1">MIFHRTPMSDFKSLDGLSIRDHYEEYRSAIEFMTGSRQKDRILAALQKNGDNSTEMLSLLHLYCQKLDVDDWELFMSIIDQIKNITDDESCWVVKIVFLALETLPRLSARLKTKICAVLKGRKNVENHFILLLSGADNVETCLEVFQAMGDEQASLFKCIMSEINTENSVLQKNIASFLVEIANNNAKLFLGFDFLDLMDSEMFVFRSCCIEILFSLIFIYKDEGNIEGINEFTETILDRLLDVNHFVRAKAVQILASLVEQQAVTLKLKNKVVENVVLRIEDKAVLVRKRALNFCTMVIKNHSFAANRYLRVERVVDEELMSEDEKAYTRDLKMFIAQMKMVISSIQDIFSCLKTEIADIVEYMKLAVFYKLDGSLGLVRFLCENIDAKQRMLLLQAFIDLFSSLKTEEDILELLDSITPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX20</accession>
    <name>L7JX20_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993893">
        <property type="protein sequence ID" value="ELQ75979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1054"/>
    <dbReference type="HOGENOM" id="CLU_2446835_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX20"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="90" mass="10499" checksum="0E2D250693CC6406" modified="2013-03-06" version="1" fragment="single">VPVTKSLYSKLVKLSKRETVELDDLEISDYAIYLLKFMDGKLFILRSICQQLMDSEDLNKRVKKHCYDTYVSGGEDWIKLTPGWSLSYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX47</accession>
    <name>L7JX47_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Integrase, catalytic core, Ribonuclease H-like, LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993908">
        <property type="protein sequence ID" value="ELQ75880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX47"/>
    <dbReference type="STRING" id="72359.L7JX47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1157"/>
    <dbReference type="HOGENOM" id="CLU_000384_6_5_1"/>
    <dbReference type="InParanoid" id="L7JX47"/>
    <dbReference type="OMA" id="FICRFIC"/>
    <dbReference type="OrthoDB" id="2186513at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="44"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="230" mass="26242" checksum="5AFE867A965FD3A4" modified="2013-03-06" version="1">MQYNLSKKYEWPGMYTQIRNFVSRCQTCLQAGRAVANTNFHMLTASTPGELIEIDTVGPLPCTPRGNKFIITAIDHFTKIAWARAVTHKSADCVLRFLTEDVLTIFPDAKNILSDNGLEFKSATTLKVMNEKGIHWKFGSPYHPETQGVIERFNDTIMRKLKKVCNFSHDTWDTAVHLAIDAYNKSFHRAVGCSPFELLHKETPLFSVDAGLVSKKHLKNFRTYTRNQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX50</accession>
    <name>L7JX50_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LTR Retrotransposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993938">
        <property type="protein sequence ID" value="ELQ75626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX50"/>
    <dbReference type="STRING" id="72359.L7JX50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1415"/>
    <dbReference type="HOGENOM" id="CLU_206113_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX50"/>
    <dbReference type="OrthoDB" id="2194291at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7648" checksum="BAFF1E0949449654" modified="2013-03-06" version="1">MKRIVETTTGSNNLTVLDLKEGYYEIEIEEADKHKTAFEFGNNVYEWCGIVMGFKNAPMIFQRVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX53</accession>
    <name>L7JX53_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX53"/>
    <dbReference type="FunCoup" id="L7JX53">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1007"/>
    <dbReference type="HOGENOM" id="CLU_040063_2_1_1"/>
    <dbReference type="InParanoid" id="L7JX53"/>
    <dbReference type="OMA" id="VIQFRHH"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="65"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="252" mass="29520" checksum="C9933E2B6C4301AC" modified="2013-03-06" version="1">MGRKEFREYLKRKESEEKELERKKAIIKDSYLNNKPVPFHLRSEARELMDEIIYETGQQKITKPLNVYVTTSRDPSSRLKQFAKHLSLILNATSVTRGNMTIKELAEQNFDVLVMVGESHGQANSLILTYFPYGPTFYFSLHNVRLLSRTKPFSTKALLILENFSTDIGLKLKESLSYIFPSVEKGKRIVVFHNKDDIIRFRHYFLEHNPEEDTIRFDMKLYKVMKGSLEFEGDPEWELRAFINTASKNNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX75</accession>
    <name>L7JX75_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleotide excision repair protein RAD16</fullName>
            <ecNumber evidence="10">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1728</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="10"/>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX75"/>
    <dbReference type="FunCoup" id="L7JX75">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1728"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_1_1"/>
    <dbReference type="InParanoid" id="L7JX75"/>
    <dbReference type="OMA" id="LLRYPFC"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="120"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="465"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="622"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="790" mass="91689" checksum="749325F620973D5B" modified="2013-03-06" version="1" fragment="single">VCFTAKLRHFMNNVKCIMKTRDKNGSLFVPMKRDVRVDFEHIIGSKKKNLNLRELTPFDYSYLRKKMEEEAKIYAVHKNLKQSEKVFRKKKVVPVNVEVPHNLRTKLLPHQKRGLDWMISCEQSPVSGGILADEMGLGKTIQVLSLILTGKMGETNLVIAPVVALNQWKDEIMKHTVGINVVSQDNQKLRNDQINVILSSYGKIESIYRRNKKSTALGNPEKEENENSSCHQHVEKNEYHDDMFLFSKIYELHFQRVILDEAHAIKDSRSSTNAAISRLKCNKRWGVTGTPVQNRVSDLYSLIKFLKIEPLGQYFCKKCECASFVWLNHGARRGFCSCGHFGSLHFGWWNRKITTPVKYFGLTSRNKKIFRLIKRITSHFILRRTKIKLEKELGLPSKQLCIIRSYFSKEERDFYESIYKKTKLEFNAYIGQCDTSYVNIFSLIQKLRMAANHPFLLSKKNALICSYCHEEVFEPVQSRCGHVFCKKEAEMYFLDNRKCPVCHLKITIDFFDEKLMKESKYNDENGEINSGADTNNNIANLENGHDTTTYRLISDEKADFMVKNEKYENNQLSLIKDKQLIEENSVNGYVPVVGQGRDDTFRGVKRSVIDVNNWRSSTKIETLIELLYKIQSNARTSSNKSIIFSQFVNFLEMLSWRLERAGFRCVKIYGSMPRSQRKASIESFQNDSNIKIFLISLKAGGLALNLTEANNVFLMDPWWNPAVEEQAMDRIHRIGQFRPIKIYKIIIEDSIESKIIELQKKKKALFNSTVENDCGALEKLEREDLIFLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXC7</accession>
    <name>L7JXC7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_0904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="JH993872">
        <property type="protein sequence ID" value="ELQ76123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXC7"/>
    <dbReference type="FunCoup" id="L7JXC7">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0904"/>
    <dbReference type="HOGENOM" id="CLU_011675_4_1_1"/>
    <dbReference type="InParanoid" id="L7JXC7"/>
    <dbReference type="OMA" id="HAAMYCH"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="261"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="441"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="730"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ76123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="827" mass="91588" checksum="21772019AB8DE066" modified="2013-03-06" version="1" fragment="single">VFVHVCYKKNKNGAPMKYVIVAGGTLSGIGKGITLSSIGLILRTAGMKVIPVKIDPYLNKSCGTISPLDHGEVFVLEDGCEADMDLGFYERIMDVLCCEMSCITGGKVYRRMIARENAGMYFGETMEVVPHVNAVVEDMIHDRVRMEYACYEGLDCVVAGGILGVNREMEEEGRAKKIKVNNGTDRRMITGRCGNVDSCGNRKVNNAVCRGTYDNNGVQTDSDVEMDAAADEMLVDDDQFVSHKQINEKNLNKRLSSSIINAMHKTKAYKTINTDDVVVLVEVGGVIDDKENDIFSSTLSHIKQKCAKEDFLVVSVDYMPSFSNSEQKTKLIQRSVQKFISRDLKPDIVVCRGPNAFFKGTKGKIVAKTGVRNVFSSKDTSMVYEIPFDLQAQGMREALLSSLNIGDRHVFKIENKLSWVFNDKKYPITVAMVIKYNGNDDSYVSVIDALKVCALMMNIDLSIKTVDSETIEKETDALPDGDVNAVLGRIFSGCDCILVPGGFGMRGTEGKISAINYARTNRIPFLGICLGFQLSVIEFCRNVLGLKDATSEEFDSTSMTKVVMVMEDHKIEKIVSGRMRLGSKHTYLVDSMVKDAYSADYRRAYLYCEGQEHCSHNGEQCSDEYNTGSASLSASECIAVRNAADDCREPAGESVPYKHGGCVSGETGAQEGPVDSQEQPVECSQPVSTCIELSHKHGSSDGRYDSNAAASDTASSTTSRFNRSTAVQPNNKCNDYNCNNADDSSHYIVERHRHRYEVNPLYVEMIERKGLKFVGKSQDGLKMDVFELNDHPFFVGVQYHPEMTLNLDDGHPLFRYFLKSALQNKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXI0</accession>
    <name>L7JXI0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993958">
        <property type="protein sequence ID" value="ELQ75462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1589"/>
    <dbReference type="HOGENOM" id="CLU_1876889_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXI0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="136" mass="15752" checksum="C22CEAA1F82155D3" modified="2013-03-06" version="1">MNIGSLFYLNSEFNNLLIKQSSGVFHLRNKFNIDIITLIQESVLEIKEEDELSTELRFEHLTFEKPLMIGENVKTVTLIDVKFVDNSIVQIFSSDVQTNIKSNCEIHWYESNKLARIEKYDEDRVMCCINNGNGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXI8</accession>
    <name>L7JXI8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993887">
        <property type="protein sequence ID" value="ELQ76035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0986"/>
    <dbReference type="HOGENOM" id="CLU_1042765_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXI8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979225" evidence="1">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="267" mass="30761" checksum="FCEE4C2739663F06" modified="2013-03-06" version="1">MELHICFCLFLSFISDIMCSNINETEQFSSDTYTNPNETHIVYYSAKFRGRTLKIRCKLPSTHVTIVPPDVLIGVTKFADTVASILNKKFEDRTLSDYLNILDILFVLEKCLCVILEDIQQGQQEYFDMAQDVFLSFQDQENYRSIISQLDEAYSNHLKSKQECLNALRYGVCSLIELSGVNTENGIINRVLINKLVTSMSPYFQETPVTYDDLVSSYQAITSQHNAYHEYFVNDTSMLKLAGYMTEDNDPDLLEILENIRRIILNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXK2</accession>
    <name>L7JXK2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Rho GTPase activation protein, Rho GTPase-activating protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXK2"/>
    <dbReference type="STRING" id="72359.L7JXK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1237"/>
    <dbReference type="HOGENOM" id="CLU_863779_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXK2"/>
    <dbReference type="OMA" id="ACIAPRI"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="81"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="322" mass="37711" checksum="54EF4D6D93B2C12F" modified="2013-03-06" version="1">MNEESITEYLVECIDSINDIETPVFERYKAQFVEQNQQIINKHVPFKTRLLIRTKNFLSENLFVCNGAFCNKSTRFSYTRIRLGQRKVLIPIEFNCIMEAILTKNLNISGLFRKSASISEFERCFSLINDQETRSMCRLEIKNRLLPFDIITLTVVYKRLFDNYDMTIIPQSFLKVLLNVSKLESKYEQVIILKYVLYMMPKSNRNMMDSIAQFFALMRYLIIYYNKTPTPNMDMYGFAVVIMPKIFLKPATAVSLDDINALIKLTEFIFENRKILFSVGVNRSMRDGSYTVDCYDSGMVAQTSRKDEAEIYRAEEVDIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXQ3</accession>
    <name>L7JXQ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0935"/>
    <dbReference type="HOGENOM" id="CLU_3002299_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXQ3"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6996" checksum="6E48F71CC93C7C93" modified="2013-03-06" version="1" fragment="single">VARKKIKDRREMMHGNSSKERLFVPLLRKMTHRKVKYVYLFVLFIFVVTLFVIKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY03</accession>
    <name>L7JY03_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993856">
        <property type="protein sequence ID" value="ELQ76309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0710"/>
    <dbReference type="HOGENOM" id="CLU_1559057_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY03"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="172" mass="20178" checksum="D2B1107AF374414C" modified="2013-03-06" version="1" fragment="single">VLNIGERAINSIMYSYSITNWSVSETTFEDSFELNSCDGSMVASNITILHLCWSDDWDRLKIFLSYSEIRIFANIKKLFVQCGMDDNPSILPPTGYTICTRHWETIAELILCMYSQFNFLEKFVIAINCENVPAKYVHDFEIYFQDRDELGQFTCEWLCKNGSEIITWIWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY09</accession>
    <name>L7JY09_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993899">
        <property type="protein sequence ID" value="ELQ75946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1090"/>
    <dbReference type="HOGENOM" id="CLU_3416414_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY09"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="27" mass="2986" checksum="59B610DA95E7286F" modified="2013-03-06" version="1" fragment="single">VKEQNKKGSAMEKASTKEVEKGLQSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY46</accession>
    <name>L7JY46_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0671"/>
    <dbReference type="HOGENOM" id="CLU_1103419_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY46"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="252" mass="29393" checksum="ED78C9A0DB45C244" modified="2013-03-06" version="1">MSASKPDPYDTPVPSDESDYELDGSDQKPLSPLHVSFYMEEQRNHAVMPNTGSDAIGSRPQRHYNPEHNADEFYRNRRRERNRRCRERRRQRKKLNLLYPGDIYPSTTELYFDQRIYEHESDENKPVSVLRTEESIKPFSDEDLRRNGFVVPHVNEEEYTNPFEGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY99</accession>
    <name>L7JY99_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
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        <property type="protein sequence ID" value="ELQ76409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0596"/>
    <dbReference type="HOGENOM" id="CLU_3056293_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY99"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6123" checksum="A016F439A42299C0" modified="2013-03-06" version="1" fragment="single">VLLNNCNHFSDEVVFFLLEKNLPRYIMDIHESVLRTPLAASFIGMGNKFNPGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>L7JYA8_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">THOM_0992</name>
    </gene>
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0992"/>
    <dbReference type="HOGENOM" id="CLU_2838363_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYA8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7362" checksum="B2C23733BAAD0E5C" modified="2013-03-06" version="1" fragment="single">VNMSINQNISFGGSIKISKLKNVTVNKMITVNVSIKEPHIQKCSGSFVINQLFGTNRKRVSKNWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYB0</accession>
    <name>L7JYB0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ELQ76458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="514" mass="61294" checksum="D027F258F891926C" modified="2013-03-06" version="1">MLLTANSLKKIERASKSSDNQQLLSNMQKEIEKNDQELLSTITTSYSQIIDFCITLNGVNESLDNLIELNNQSNSYLQDTAQKIQMNLEELRSIDETEKNIDVALTTLQKIDRFNTSIETLQDITDICELVAELGMLERCLLDFKKFGFYSKFNLRLIDNRDKIFKRIKNNVKEWMRKVGELFNFLGSEFVRMMNNEHSMIFDFRYNLMKNVPIQEVYDFLYIFGTLKDRREIIDKMNYLRKNSTFTLMKDHDAIENDIYNVIGFLLVDFYLLDIDISFDLKENYGNLVHRLLQNIKNKKSDIYEHKNDLLVLKEALVALNYRYKDVEDELFKIIFTFFQEEKANITTFSDIESYISKCKKIMENYSIKDIRMLFYKNVDDLLLEYFCLDEDYLVVLDRICGEFVDYKFRAQNKKSREITSNYNRIKDYHLKVIDKALDERDFERFNQLIQNETSELNDIKLNSNEKKELINDMKAYCMNKLQRREKLDGPKEKVNFNAKKALLMKMFEQNLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYD1</accession>
    <name>L7JYD1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0585"/>
    <dbReference type="HOGENOM" id="CLU_3178060_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYD1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="47" mass="5218" checksum="167C3797C929AC25" modified="2013-03-06" version="1" fragment="single">VTDKSYMMENPDAETITSGPEKTMELKIETGGIEGENENHICFEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYD9</accession>
    <name>L7JYD9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0701"/>
    <dbReference type="HOGENOM" id="CLU_3160278_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYD9"/>
    <dbReference type="OrthoDB" id="10311367at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5534" checksum="31B4D92349B169ED" modified="2013-03-06" version="1">MHRLVAKSGRRDIPNNTRIKLLENCVLNDLDADKESEESDFLSNFVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYE1</accession>
    <name>L7JYE1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0515"/>
    <dbReference type="HOGENOM" id="CLU_957080_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYE1"/>
    <dbReference type="OMA" id="REHAVIF"/>
    <dbReference type="OrthoDB" id="10501291at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="291" mass="33024" checksum="DB5961FA4F2F9985" modified="2013-03-06" version="1">MLAFLSKLNVSFYKLYIAIIPILSSLLTMFIHSRSTTMKINMPLSLGIIIISTINMLFQKSSTTIRDCSEIITLGCGLGILAQFLLNVSLNMQYKVLVDVILKMFERKIIYNLLPILFSAFTDLGIISFLNREHAVIFKGICSVLTMVLMTVVLKQLGLPLYYDWRIVLPLLIIPSFFLMVFLPSKQTSETGKDNNKYRRACIRTSCFITSITITITCFLYLLYYLQTHNSVINNGAHVLNFVSNAGSVVSTCWNKIKHGATQTMSFIQSLPNKAKNWCQSFYNMLRSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYN8</accession>
    <name>L7JYN8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin holocarboxylase synthetase/biotin-protein ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="JH993838">
        <property type="protein sequence ID" value="ELQ76549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYN8"/>
    <dbReference type="STRING" id="72359.L7JYN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0460"/>
    <dbReference type="HOGENOM" id="CLU_1035112_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYN8"/>
    <dbReference type="OMA" id="ICISESY"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="245" mass="28011" checksum="0734CE1B1C971BEE" modified="2013-03-06" version="1">MKIKWFKTISSTQKHLINSTSTYKDTYPVIATMHQTRGVGRTNSTWQSLIHTLSFSYVTHAHVAYIDVIGRVRHVLVDQGVDALCKWPNDVLVRNGETYHKVCGALIDVIGEYAVVGVGVNLGYTCTCTIGCDKCTGISMDEWCTEDNKEATCDGQYSGNIANYKTLRDVTGVEVTPLQFFEHYFTAADRFYTYDWRDRYVNYRGERMEIIDKRELRLKDRNGNIHLIDPMVCSYDYHSNSIVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYP3</accession>
    <name>L7JYP3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0298</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYP3"/>
    <dbReference type="STRING" id="72359.L7JYP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0298"/>
    <dbReference type="HOGENOM" id="CLU_960380_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYP3"/>
    <dbReference type="OMA" id="NNRERMR"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="290" mass="34656" checksum="17C308E6E6BD2A8C" modified="2013-03-06" version="1">MKWEKTREQKDEYIVESPVGAILSTDGRRLRASRENMYVGLFTRSGKNELEHLDLIAMASLRGLQREKDMSLLNNIKKENNKYIREKSNNRERMRKKPTELSDSSEISENFEVRKPKSKYSTVETSHRKVKVNLHAEDENAGKDKTALDYLLEQAEIESQKMAEIERIEQFRRDREQAIRMARMSRRESEDVGHDEIDYLYDGYQIPDDIFKVEYENDNKMYYCPKKNCGKNFPSLSRVKRHYIVHTGKKPYKCLNPDCKKSFSRKDNMLQHYRNHCTMSRRKRFKEYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYP4</accession>
    <name>L7JYP4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993911">
        <property type="protein sequence ID" value="ELQ75867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1172"/>
    <dbReference type="HOGENOM" id="CLU_3191629_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYP4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5500" checksum="1DBA2ADA0A56063F" modified="2013-03-06" version="1">MISKPFYTYYDLLISCYTRKLSKNYVSCQTVMISTKMFLLCILFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYV0</accession>
    <name>L7JYV0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras1 guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993861">
        <property type="protein sequence ID" value="ELQ76196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYV0"/>
    <dbReference type="STRING" id="72359.L7JYV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0829"/>
    <dbReference type="HOGENOM" id="CLU_806983_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYV0"/>
    <dbReference type="OMA" id="HAVMREM"/>
    <dbReference type="OrthoDB" id="25179at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="332" mass="38396" checksum="B46F8F8AC3354E78" modified="2013-03-06" version="1" fragment="single">VMLYELENFVSKKYGRPTYTGKKKDVKVVRNERSTTTASTCKCWRKNEFPLSLLLEKVESKEVNENVLYGKFTQIDEMNANEFGKVLHNLDLRLYRKIMPTEIVEYGKTSNQNNGNDENMDDGSVDGQQDVRDNKNRTVEGRGNETNSAETINNEMSENLKNIIEKNRALTALTSIKISGGLKSSFFVRVCRYLKKRNNYNSIVAILNGLRTHKTNRSFREFNPPKKYDPNTTFIILPIENILADVAISNQETMSEGANMFFYGIVKFFIMLQDKKCKVDVELEHAVMREMVGVKNFCFDEHEESRNIFLASYLYVRVRKNKQTSECGSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYV9</accession>
    <name>L7JYV9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endonuclease III</fullName>
            <ecNumber evidence="12">4.2.99.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="12"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYV9"/>
    <dbReference type="FunCoup" id="L7JYV9">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0335"/>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_1"/>
    <dbReference type="InParanoid" id="L7JYV9"/>
    <dbReference type="OMA" id="WQQFTHL"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001435">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="11">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="201" mass="23277" checksum="F6A8D60EC3E3524E" modified="2013-03-06" version="1">MFVCTVHKNEEHRKFRVLMMLILSQQTRDKTTYTTIHNLNELLVRKYGEGISPYTISLLSLDELSSSIKNANYYIKKAKNIKMIAEYFVNRKMATEYDELVKLPGIGNKIAFLYLQIACNKTVGIGVDTHVHRIFNRLGVVTTKTPEETRIQLEQIYDKEEWGQINKVMVGFGQTVCLPKKPKCNECVVNYCCKYGKKFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ69</accession>
    <name>L7JZ69_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1</fullName>
            <ecNumber evidence="8">2.3.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="8"/>
    <dbReference type="EMBL" id="JH993821">
        <property type="protein sequence ID" value="ELQ76743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ69"/>
    <dbReference type="FunCoup" id="L7JZ69">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0269"/>
    <dbReference type="HOGENOM" id="CLU_020445_3_1_1"/>
    <dbReference type="InParanoid" id="L7JZ69"/>
    <dbReference type="OMA" id="PHEEGCL"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="284"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="385" mass="44109" checksum="07CBE0465DB9C4D4" modified="2013-03-06" version="1">MSVEDESKLKEQKIINEEYKLWKKNAPYLYDMLVTHSLSWPSLSVQFFPEATRNEKNNTTTQRLLISTHTSQNEDEFIKILSVTIPDTVFSDEESYDVRIDTEQQIRVKDDVNRTRMNYKMSNLIAARSDSEDVHVFDYTKHLSMETTFMPELILKGHEKGGYGLSWNYNNKNILATSGEDGLVCVFDIEKNTAEKLAGHDGVVGDCNFSFFSENVLFSCGDDRNIIMWDTRTQKHEKLENAHTAEIYALSCSMLEDNVICTGSKDTSVKVWDMRKTQKELFTLLSHKKEVLQVQFSPHFSNILASSGTDRRVCVWDLDRVGTLQTAEEKEDGPPELLFLHGGHTNTVCDFAFNGLEPWEIASVAEDNVIQIWQMSRAQKEQNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ76</accession>
    <name>L7JZ76_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_031976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ76"/>
    <dbReference type="OMA" id="DPECNTK"/>
    <dbReference type="OrthoDB" id="2192975at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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        <location>
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            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ELQ76714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="551" mass="62357" checksum="0CF5D537F54C3783" modified="2013-03-06" version="1">MLNMLNNQFVIQKHVNHIQNHLFQHLIINQWCKNRSHQMKRSFLILSIFGLYRALNLLDRCKLYNIDPKHCQNSIYVPNTYYDNYLKSFNMPIQKDPECNTKNCLIVVYKEPPRIAVNSTGSSSNFCENGFNLQNFSVCMPSMQYSTNIPTITSGPEAPGRIVIQTLTVGPSSTNDTITLTGMTPKVITKTVIIAQTDDNKTTEESNTDSSTKSKEKTRTITKEVTTTIGRTSTDECEKSSDGESNKTSEYNSETKSECSSEKKTKENEIKTVTVTKDKNKTDEEKTKTVTVPPTVQPPDDKKTTDQSSTSDQSSQSSSTQTTPPPVPPTTSIPYINIEEIKKIIREKDKLCKFGRNDDNSCKECDGEGCSKRRKCKGENENECHSDETARSDSDEDQSSEEEGKKHSKNRKKRPKNKSKNDKTNKTTAGGSEKYITLLRYKTSTVTNEIPITLYRELLKTVEKEKPLTRYKVTTVNNTVTATVTKDRYKTTTVTSKKEITTTMTLQSSKNEQEEKTSSLTEPPKETLTKTGSCLRVQRIKHPQVRKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="InParanoid" id="L7JZB1"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="129" mass="15484" checksum="C4084D333494EC9A" modified="2013-03-06" version="1">MVSEEELDPCLIIPFQHTTDSKVSYDISFFMNALKRLFKSICLFYNYEMPLCLKLSNEQVYGLAKHFWQILMEENKRLIQQFIPELFSLRKELDSRPGTFYPCELYQIITIIYSTSHLHHMLKCIDKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZI8</accession>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_3362240_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZI8"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4352" checksum="FD39CBF206A43A40" modified="2013-03-06" version="1" fragment="single">VKMLDITVEQMESIELCMAWFTEKLRGFLQSHSRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZY5</accession>
    <name>L7JZY5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subunit of the major N alpha-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="InParanoid" id="L7JZY5"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <dbReference type="GO" id="GO:0016746">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7453" checksum="3B7B9C08868F88F6" modified="2013-03-06" version="1">MHVFINNNSNSKVTLCVRVSNYRAVKFYVGRFNGVIKYVVRNYYENGDDAYFIVIEGKCCCGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K006</accession>
    <name>L7K006_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi incertae sedis</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ76352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979174" evidence="1">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="38149" checksum="80138A824ECFAB20" modified="2013-03-06" version="1">MHNLIILSIAILAFALRGVAARPWASEGVGIFRAECFSECGSDKRRHHRPKGCDDGIYDFYPDSSICESECDSSCREKERHVAQGRRILEKCIVPLVLEVSCRDLTERECEILLKAFDNLRQYIYKDFEAYEHAWDMMDPLKMYYIAFCNLVLYNNPYAIQVARCVKESKTCVGTLSLKICGDSTTFSMQGSVNFVVVNPIAIPLFMLKPAMFLGCPIEVDILLFKYVCAMLIRVHKERGVGGSGCHRGVSKLAKLFQSRCHMHDRNSVFAVKMVIIKLCVDIRQNKIDWSFKTYCNILVLKKEGDHERRPPCDFTAAINYYFGTIGSCNNTPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7K040</accession>
    <name>L7K040_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ELQ76422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K040"/>
    <dbReference type="FunCoup" id="L7K040">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0609"/>
    <dbReference type="HOGENOM" id="CLU_178987_0_0_1"/>
    <dbReference type="InParanoid" id="L7K040"/>
    <dbReference type="OMA" id="ECEREHR"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="9331" checksum="6ACA4F765CEC77BA" modified="2013-03-06" version="1">MNPSEIINFKIFYPKIMAEKVYIGKVIKKIERSGPGGPITLCQLELTEEKRTLQRAIMGPVQEGDLIMLLDSEREHRRGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K058</accession>
    <name>L7K058_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K058"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0427"/>
    <dbReference type="HOGENOM" id="CLU_1082539_0_0_1"/>
    <dbReference type="InParanoid" id="L7K058"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="257" mass="28828" checksum="D499D3162C7EFA4A" modified="2013-03-06" version="1">MRFNPQVSIMLGAFVIMQVFSNNVMARGSRSRHRGSLFGLGRIFGRRRHGGNTFFQSIVNTIESIWGRNSATTKQEDQGTKEVAEQTAMKHIIMPASNPATDIMDEKTLTLPNSRKGVKRIYSVEKKGTDSSSTKLEFATPTVENALNNLMLFLGDGLKLLSEMVNEKFDALDFIRGGDFNDTMIDEEQDSIRKQLRVQLDRTNRIFNDKEHGILTCVDETNNTFDLNLIAAERFAAIVENIEVLLADVSLTNTNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K081</accession>
    <name>L7K081_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K081"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0210"/>
    <dbReference type="HOGENOM" id="CLU_2225194_0_0_1"/>
    <dbReference type="InParanoid" id="L7K081"/>
    <dbReference type="OMA" id="NHEMIFR"/>
    <dbReference type="OrthoDB" id="10333085at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="12820" checksum="E633E4C7A8D2FE86" modified="2013-03-06" version="1">MTDCHILPFYTAKSGNKDELPALDLTNHEMIFRGTLLVRTKLQNINAYIDGQKIEEMVLWKPKFAPSVLEKELEVLDERTVMVNTKEKNAIARCRDLREVFKASKKRRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0A1</accession>
    <name>L7K0A1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993838">
        <property type="protein sequence ID" value="ELQ76547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0A1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0458"/>
    <dbReference type="HOGENOM" id="CLU_2580503_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0A1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="7925" checksum="68B1895B0C5C73AD" modified="2013-03-06" version="1" fragment="single">VVGKTVVRDSRDVVVVGEAVVAVIEGIVAADVAGRDAAVVEDAAADAVVPDAAVVEEAAADAVAQGAAVVGAARRMQTIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0J0</accession>
    <name>L7K0J0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0J0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0206"/>
    <dbReference type="HOGENOM" id="CLU_2832977_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0J0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7654" checksum="A212B6670D8E3217" modified="2013-03-06" version="1">MTQELLDKLSELNEDSKELLDKLNQFNASFDTVTLNFKNMEQILGQVKKAFDLYKEVTVLINKSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQZ3</accession>
    <name>L7JQZ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3234"/>
    <dbReference type="HOGENOM" id="CLU_398594_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQZ3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979047" evidence="3">
        <location>
            <begin position="25"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ73859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="691" mass="74416" checksum="605D65CB6C1DF9AC" modified="2013-03-06" version="1">MRCMQVNSTCYVLFIFKLIHAASGGGSGTQGSLAEELCTVIQDYGESTSNGTSIMYHRMDFTIAQGDQATGLHIFEPALPLSEIVSYAVHEQQMSANNPRQMKKVDALLDAVRAMNCAAKVVVNAYFLMRQGGARGTQGQVISDIMAARQQAFYDGTLRQGAAADVSGSGAFSRAPGADARSPDQARFDAMMAEYSKDREALQDVIRKGEEREKQMSKDIDELLSQCNEAKKQKEALTEELRVLNESLAPQVIISPYLRQLLACRSTGKDVLAPEEAVRAVESMDITQVIDCLIAVSEDLLQERDGAMDKLVKVLEETTSISEDFQGVIDSHSSESKVIRDVSRRLNTVRERVTCALDEYSGAPIKPAREMRPAVLPGQPGLRILRYVPGKVSDRGVLAPEAPDASLRGPAAPGTTVQLGPGPQQGPSDFFSAFLDCYSGMTESLRELDNELDEAVRVHESLLKAKTPKLVVRGAALMTSALKRYNKTVQNQQAARKMIDSAKSVVPCSDPVLHSIAITLEDNEDILAALTQKLLHLNNVYAQVYGQSFFLPESEAKGAESTPAGAVASTSSIPTSTPGARLQARVTQRYAAPVEKKSGDQEQKTARKTPQISKHVPMSQLGTALGSIWQSAFGQVSSAPAVSSTSASASQRASGTIAAPRIILPSSRAPGSVTSPTYGTAIRLRSFMPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR97</accession>
    <name>L7JR97_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA helicase, Helitron</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR97"/>
    <dbReference type="STRING" id="72359.L7JR97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3104"/>
    <dbReference type="HOGENOM" id="CLU_184018_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR97"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="92" mass="10474" checksum="284250886BFFD721" modified="2013-03-06" version="1">MPPHKLVLKRGALIMLLRNLDPANGLLNGTRLIVDELYNNFIIATIVTGTKKGNRVIIPRIEMALSETRLPFIHKIRQLSFFIFLTVHKSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRP2</accession>
    <name>L7JRP2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2922"/>
    <dbReference type="HOGENOM" id="CLU_2172833_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRP2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="12335" checksum="3FB00BBA87606C2D" modified="2013-03-06" version="1">MPGQIRSHNTMLLSGTASTSRSYMDKNDQDSRTSLILEFFRDNDVEDVYTLRVLSSNDAKNENGWNEVARKLDAIFSYPEIFNVFLGSGFNDVWVSPSGTEDASLSRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRS9</accession>
    <name>L7JRS9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase, Non LTR Retrotransposon</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="JH994070">
        <property type="protein sequence ID" value="ELQ74139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2945"/>
    <dbReference type="HOGENOM" id="CLU_403668_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRS9"/>
    <dbReference type="OMA" id="IECTINM"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="742" mass="85075" checksum="AAD65C269E7309DB" modified="2013-03-06" version="1">MKREISDCDRPILWSEVRLTLKSVRRGKAPGVDGIPYDFYKCAQDDIELEHPLSRTLYLLIHRSFMTGKIPDRWNEAIIVPIPKKGDMSRTDNYRGISLINTVCKIATKIVAERISRICEANNILINEQAGFRRLEECVAQATSLVEILKRRELEGQTTYVVFIDFTKAYDRVPHGALLHKMKMLGLNGKLLGFTEALYRSPRASVRVGEDTSECFEYQIGVKQGCPASPILFNIYINDLFEGLSGIELEPGAKPIPGLLFADDAVILAESLAALESDVRKLEEWCNKWKMRVNIDKCGFMIFGDETVATISWMGTEIPRANEYRYLGLPVDKELSLKRMIDDRRTKGLHAFGALRNLLRNPHIGIPIKVQVTKQILTPICTYGCELFGMSAQRVTRLQRIIDWAIKDVLGTGPSFCRKAAYNELDIAPVELRAAKMRARGFTKWKNSRTTIGYLLNTAFKNRKATWMTGTSRWLKKTLKDNPSENIECTINMVEQKLKERHIRNDKSKCKLIRETWKVGTVMKFKKLITANYQLTNGWRTFVKLRTGNFSSCTRLAKLGYIDNKYATECICCHKKEQETIFHLLWMCPMWKDERTNHFGWLKQKHTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNVEWVDENKKIYIILCVQNKHIVKYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRY1</accession>
    <name>L7JRY1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B-cell receptor-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRY1"/>
    <dbReference type="STRING" id="72359.L7JRY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3012"/>
    <dbReference type="HOGENOM" id="CLU_1195600_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRY1"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="232" mass="26339" checksum="433991386026904E" modified="2013-03-06" version="1">MSLTLLITQSFLLSELLFLTVLLLPFSPQKLTIALPRPVHHLIYALVMLIAFSFADSLYRRSYQQYFYLNGITLFLFLILKRMLNVVGRLKREEMEVSVMRRQIENHKKFVMEMVEENKKLKEENDGLRNRVVLGKDVGVREDSGRGGDDGVVRNRVTGQSDTFGSINSTAGTSNERATSSNTTDTRKDAPPGNMVDKKNNSLAGTHKTVDDGKAAPLRNEENEDENWEAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS33</accession>
    <name>L7JS33_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Vacuolar (H+)-ATPase G subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3231"/>
    <dbReference type="HOGENOM" id="CLU_154776_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS33"/>
    <dbReference type="OMA" id="HPIMASE"/>
    <dbReference type="OrthoDB" id="2193583at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="137" mass="15667" checksum="6CDDDE70362F68E9" modified="2013-03-06" version="1">MDVSFLIHQTFSVSNILFCSKTKNLHAHPIMASENVKKLVECERKAKEMVGRARNERADLLALSRIDADIAIAKLREENEQILEKERVKENEEVEKLIKELKEVRENDLREFGTEIIGCEKLVDDIVSMVSGTAIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS38</accession>
    <name>L7JS38_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3001"/>
    <dbReference type="HOGENOM" id="CLU_1005390_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS38"/>
    <dbReference type="OMA" id="RCKFVYK"/>
    <dbReference type="OrthoDB" id="2189995at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="277" mass="31713" checksum="8E038143C3E2990D" modified="2013-03-06" version="1">MDKSIVDDSYLLFKFIKDVRHDKHTNKNGQNGTNTGTHTVRAHNYADDDSSALDDMCYRSSVRSDSMCSYEDVITRRNSVRSSVVDDSDCMGGYNGMESGNELGYVMSFCGNEIDGGQRVLPTCDAHGKCNIDKTCGRTCGKDNTDEDTYKRNTTYDTTYGNTYGNTYDKSINTYDSNTYDNTYDNTYDSNTYDNTYDNTYNVNAYGTTTNSSAINIDTRKIREKAENQNLNEEMKKYFHKITSIRKKVFVCEYCRCKFVYKKCLVNHVEKNHFGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS81</accession>
    <name>L7JS81_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyadenylation factor I complex, subunit FIP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS81"/>
    <dbReference type="STRING" id="72359.L7JS81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2813"/>
    <dbReference type="HOGENOM" id="CLU_156758_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS81"/>
    <dbReference type="OMA" id="YCAKQRS"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="133" mass="15776" checksum="F2148C76E092D8ED" modified="2013-03-06" version="1">MNDDILYDVNLDDQSSESSTHLEVIAEQSRKEVSAIPEMPTIAGKNLFEFEIDTIEDKPWRRPGADITDYFNYGFDEHTWKLYCAKQRSLKEEYKDDNKETGEISPSKERRRAGKSRDEYRGREEYKRRHGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS85</accession>
    <name>L7JS85_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">superoxide dismutase</fullName>
            <ecNumber evidence="2">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS85"/>
    <dbReference type="STRING" id="72359.L7JS85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3302"/>
    <dbReference type="HOGENOM" id="CLU_2270291_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS85"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="103" mass="12248" checksum="AE3C7A807DA6E389" modified="2013-03-06" version="1" fragment="single">MYELPELPYEYDALEPQIDENTMIIHHTKHHQKYIDNLNNALKDTKYPETTVGLLLNLIKKTDDLNDDLRNVLYFNAGSHYNHTMYWHCMSSEPAHKEMMKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSC0</accession>
    <name>L7JSC0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2767"/>
    <dbReference type="HOGENOM" id="CLU_3002303_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSC0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6734" checksum="405CF3409EE7D727" modified="2013-03-06" version="1" fragment="single">VSIVFKKKSILYSMPLVNMRDDFCKYEHRLDCTSNVEKNKLSKIQIYILPHGNRGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSC2</accession>
    <name>L7JSC2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2913"/>
    <dbReference type="HOGENOM" id="CLU_1020096_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSC2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="273" mass="31359" checksum="9F51933EDA56CBFB" modified="2013-03-06" version="1">MNYYNRCKLEKRLGSIYRCVGSLSSELADCIASVERLSEDNDRSYEGIKTCLKILKDIKKFYPSNKCSGGVEEFNEETVNDNSEVMQSMDDEFTDNAVDEEHFGINYESDNELTWDYDYTMTFSSGKDDTAVTNPLVIKSTEQDFQTKQSTMLDENSTITDDKNVCTVIWNENYENNKESLEEKRKEERRQKGEEKKKNVEENDTMKEKEKKAEERGNCEKKKSEMDDSGSGKLKSEEITSKTVNSAYSNAMKSVFFFGICMIVTLVAIKTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSC6</accession>
    <name>L7JSC6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar H+-ATPase V1 sector, subunit D</fullName>
            <ecNumber evidence="4">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="4"/>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSC6"/>
    <dbReference type="FunCoup" id="L7JSC6">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2892"/>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="InParanoid" id="L7JSC6"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="24105" checksum="2FF0E40C7638DE48" modified="2013-03-06" version="1">MSTQNRLSVFPTRMNLTLTKNRLKSAEKGYSLLKRKSEALQVKHRQIQHKLEKEQHNLKTAITNAYYLLAKAEFLGSNIKMFLYECSRSPVSIESSIEQVSGVFLPVYTLKQDVGNPLLFLDKSGSAYLSARNAFRTVIGRLIELASLKNSFVILDEVLKNTNRRVNALDFMLIPRINNTIDYINAELDEQDREEFFRLKKIQKTKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-05-29" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSE3</accession>
    <name>L7JSE3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2712"/>
    <dbReference type="HOGENOM" id="CLU_2851319_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSE3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7515" checksum="3A6729D903EB737B" modified="2013-03-06" version="1">MEDISKRIIQHLLLLPMTPLTDRKKMKRSYNDSQYILNSPLTPHLTRGEQSLAFHPCNSSFNSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSG7</accession>
    <name>L7JSG7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2842"/>
    <dbReference type="HOGENOM" id="CLU_164198_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSG7"/>
    <dbReference type="OrthoDB" id="2194264at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="Zn_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon 15" evidence="1">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="103" mass="11768" checksum="932E5B9556987363" modified="2013-03-06" version="1">MCNCMICGLTSRKITKRNENGVIDVYCPHCSNTVTSCTIYEKYYFSFFFIPLCPVKTKKKYAGCGVCKIKFSDGRVRVCSKCRSVVLNSYRYCGRCGDEVSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSH1</accession>
    <name>L7JSH1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2847"/>
    <dbReference type="HOGENOM" id="CLU_2980757_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSH1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978774" description="Transposable element encoded protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6725" checksum="C72CEEDFA14A64D5" modified="2013-03-06" version="1">MLFFKHQSIIFYYLLVLNGFSNASVDHIDLFPRSKMKRADVETKNIGRNHIINPICSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSI5</accession>
    <name>L7JSI5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2827"/>
    <dbReference type="HOGENOM" id="CLU_869036_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSI5"/>
    <dbReference type="OMA" id="KRYYLAM"/>
    <dbReference type="OrthoDB" id="2195260at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="303" mass="35927" checksum="11FFB0084433A2A6" modified="2013-03-06" version="1">MLSILLPFPLFYKLFYPFVSAMRRISSFTATELLYLAHKMRRNVYTPSMYELLRKKALENNYTSCVAYAEDMRFKKLIELYKKKKILQEQCFNRSFIPNCKERRDLINTDKRTQSTVFSYRYTQETSANKPLGTIVHSSNLFSLHVQPSVQTPAPVAIPLDQNKLHKRYYLAMTEEEKELDDFLDKLEERNYGKSRSKNLVKDNFPILNKEKVTDAFSFIFEKVTTRKGIKDKNLWPSEYQVVLKKIKEELGLELSIGEDMQLVQAVLKALMVLQKWIFDKKEVVKAIYFKKMVIAFYDFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSM6</accession>
    <name>L7JSM6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="3"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSM6"/>
    <dbReference type="FunCoup" id="L7JSM6">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2578"/>
    <dbReference type="HOGENOM" id="CLU_082080_1_1_1"/>
    <dbReference type="InParanoid" id="L7JSM6"/>
    <dbReference type="OMA" id="THLFQED"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="186" mass="21643" checksum="D60D8FFA8D2F81C9" modified="2013-03-06" version="1">MKLFYFSSNVNKYNEIKELLPFPVHFQKARFIKQQQTLDETVLKKLKQLQNLYYHQAMLVDSTSLEIAGLHGLPGPYIDAFLSLGYDNIEEIVKKVGRRAKVKNVLGLALFDEFILFDGVCDGTIVETRGEYSSGFDKIFMLDRDCYTLAEHVFKERKVISPRGHSVFYLLKYCEKNKITHLFQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSN0</accession>
    <name>L7JSN0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3008"/>
    <dbReference type="HOGENOM" id="CLU_1983255_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSN0"/>
    <dbReference type="OMA" id="DDDWLAY"/>
    <dbReference type="OrthoDB" id="10536960at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="129" mass="14437" checksum="BA0B31E4A0C1F82A" modified="2013-03-06" version="1">MQTMKPEHKKYILWGIVLLAIICLSATVIYFGFFYNKSEDDTEISSPKRRPSETKASGNVPNNNSDTTEDDDWVVYTLERVKELKDQKDGLLLLVKLIKEIINELGAGAKDFFGLGNITPGSTAPEIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSP1</accession>
    <name>L7JSP1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Chromatin assembly factor 1 subunit A protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSP1"/>
    <dbReference type="STRING" id="72359.L7JSP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2629"/>
    <dbReference type="HOGENOM" id="CLU_1267684_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSP1"/>
    <dbReference type="OrthoDB" id="2193302at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="1">
        <location>
            <begin position="110"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="218" mass="25677" checksum="220B2C1D8613D54D" modified="2013-03-06" version="1">MLQLKNLKRQGRTSKSTKKCMETASSVKIEDENNLTQDMEGIADKDVKRIKRPSVHSISNYIKREKIVEIKNKDDRKFLPIDFPPNTLIFQIGHTIKSVRKYQVGKKLTYVKFHDTIRPSFHTICTKYKTSNSVKRIPFVLNYDEDSDLLWNDDESGESINYATDSEEDMVEEDSFECSWIEEGEEYNTKKVDLSFRMIQPNMKICFLKDQKKYKFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSX0</accession>
    <name>L7JSX0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2486"/>
    <dbReference type="HOGENOM" id="CLU_1807582_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSX0"/>
    <dbReference type="OMA" id="CNDLIYK"/>
    <dbReference type="OrthoDB" id="10347755at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="17138" checksum="64467B62DE4C2266" modified="2013-03-06" version="1">MSSFEKLNICNDLIYKIIVDNKSRKFVSNIFKLREDQPGYIHVETRILKDYVAKINTLSFLHIYRIILRLEVLKRRDLLVQLKDKLNALTKKRILLYILRNKSSVRPILSESIFQFNKRLNAKGIENTRNLFWDIWNTNLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT53</accession>
    <name>L7JT53_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2595"/>
    <dbReference type="HOGENOM" id="CLU_1628217_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT53"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="163" mass="18336" checksum="33B3F182BD244FED" modified="2013-03-06" version="1">MTSFIFVFSNFAALRIYRLENFCPTISMAFNLEKPVESIETLSKETYNVLCTPFTGIRSSFTINRGALLAIENGNMSSNIALLYSTSNFLSHLLIDNDKNVFIKSVFVQKNVICKNTIVMNRNNPVTDLNIVFNLPLTVSMNMIVDKVANYKIGVITKIKTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT87</accession>
    <name>L7JT87_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2423"/>
    <dbReference type="HOGENOM" id="CLU_034494_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT87"/>
    <dbReference type="OMA" id="DHTSAYV"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="8">
        <location>
            <begin position="447"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="572" mass="64884" checksum="3BA7EFD0F508A826" modified="2013-03-06" version="1">MKFSIRHPKGGEFGKKITVADDFILLNFMYNKKDHSVILVGTRANKKSLVTLTLKSSEGESNIPTQIRTWEHALDFRIYHVITNLVDQNAGNVFVIVESVNEERVRMHYLSASTGASRVLCESDIMPLMMTDGEMDPCFLIRDGTHTRVLILRGNAVDNQTVETWGGSALGSIMRDHTSAYVDVDNDSRADVLIDTQEDGERLLLLILTHPSSADKKVQRVRLPEGSGPLIFEDLDRDGKVDLCYVCANSEGNHLIIHFNQYENENDVVFSSETKIRKIDLNEMFPEYDPVMRIADLDNMPGGIFVYDMELKQFPNVVLLMVNKTTGEHNLKIITSVTEKDEGTLFFKKKEKKREIQFEASKYRKVLSLDYKHIVSMSCWDPDSLGREGLLVNAISDGKYELLYYENNLEVNHYKLSLITLDGRKSADGATAYNTPVPGVSYRVSFDNKTLVNNQMTQCTFLNLKKPIVTFGLGSTNLLIEKIRIGIPRAAGVLEVDQKIIPNSDLVFTYRNGKISIELLLKYGFYIQIVFCVLLVVLFLNLLVVLLFTYLERRKKKLAKKKEASAFNFKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTB9</accession>
    <name>L7JTB9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ74007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTB9"/>
    <dbReference type="FunCoup" id="L7JTB9">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3100"/>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="InParanoid" id="L7JTB9"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="3">
        <location>
            <begin position="243"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="444" mass="52475" checksum="8E3FE76D6B129B2D" modified="2013-03-06" version="1">MSLHSEDEYGGCKYSISCCKCGISILPNCLNMCGRCRSTEIDITQGVKLCYTVENCKKCNRYLLPPKKWLVLENETDLLSFLLLRYKEIRNLNIVNSGFKKTEEHSRRIVLELEIAKDDLKCNIDVVFKIRNKQCLDCDKMEAKQYWTSIVQIRQRSKSKRTFLYLEQSILKHKMYKRCTNIKERKDGIDFYYLDKHSAYEMVNFLESTIGTKLLVSNRLMTEDRNNNKMKYKFSYSVEIYPLCKDDLVVLSEEFAKKRNVGRLVLVLKVSRKITLVDPISSRTIDVTNKCFWSNRECFTVVMTSKDLTLFQVTEIERDYQKMYGTAEKTESCFKSVDCFVRREYNNDMHCKSHLGSILREDDEVYGYDLGNCNLHFIDRDLFKAILVRKNYKDLNLSINTEKEHDREYEFFLEDVLEDDDLKKNVDLYDRTTKVIANLESMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTE5</accession>
    <name>L7JTE5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translational repressor Pumilio/PUF3, RNA-binding proteins (Puf superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTE5"/>
    <dbReference type="STRING" id="72359.L7JTE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2759"/>
    <dbReference type="HOGENOM" id="CLU_495398_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTE5"/>
    <dbReference type="OMA" id="RECSTAY"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="233"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="392"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="497"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="557" mass="64322" checksum="FDA831ADDD2C945A" modified="2013-03-06" version="1">MSTTPLPMDTYRHGQVKTSEVSYNTDYADECDSSPVNENSCTKSDALQKNSEPVDMETDEARAGITDKDVDMRVGERLISCLCDFASFLVDNNDVSVNKYSFPGSYRGSNSVQNIFSPILSTSCSPLETFLKEKNISLTSIDSLKSTYYGNRENKEEEMDSRPFIGSSMRMMEKTSERKCKTAKPTLLEMIDNDNPRECSTAYPLKTPSSLTPIGDDFSFLTRIFTEERSYEHKEDFVNDIQVYLSRKNKENVVVDIDTCTNIVKDQEGSRFIQKRLELSTEEEWIWLVKHIRIKELCIDLFGNYVIQKLIENRECHGYITQYLEGCYKEMSVNAFGCRVVQRLLDEDVNEESEYYRRIADELKAHILDLVYDSNGNHVVQKIVERKIDFENVFYNDCIQLSNHKYGCRVLQKLFEKNESSTIINKLIDNCLDLAENQYGNYVLQHIITIKHEYLVRVSDILSPYIFSFSLHKFASNVIEKIIKMCDEKQLNGILDDLLANNSIVKMSMDKYANYVVQRILESKSRERVVNVLMANINELRNCVYSKQIVVKLSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTF0</accession>
    <name>L7JTF0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2519"/>
    <dbReference type="HOGENOM" id="CLU_765479_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTF0"/>
    <dbReference type="OMA" id="DEDYNCE"/>
    <dbReference type="OrthoDB" id="10532765at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="389" mass="44728" checksum="D448AF0CBA87EAE4" modified="2013-03-06" version="1">MESTSSSEDNILETCIIDSSDLESAENEIDGPSQSKNTEELAGTTDSLSRIEGGYESEKTDKNEDVDDRNNEKCASDNEIEYYKSDTKRYNEHERNDSEDNNMIEMHSTPEISYHINDPINTEVAKKSHGVPSDQECLLMGPCPEDPKKMENLVNTTPKEKDEKKEELNSCEMVKEKELNEKKQENAVTANDNDDKDMEDGTEVVEEQKEFFHNEGKADKNDVSGEKEDVDDDKEISNNSYKEENDEPRDTVDDTELVDNVSLKDQGIAEQDNESVSFDFKELIAAINGDVDHDVVRNVNIIDPGVPNYNKKIFIDDIVRDERSKNIIEEVENRLCGKSDKECETEEYVRKEHENVTHGNTEVQQNESKRNMKMSWNMLQRKEMKMRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTH8</accession>
    <name>L7JTH8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994034">
        <property type="protein sequence ID" value="ELQ74630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2441"/>
    <dbReference type="HOGENOM" id="CLU_1563987_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTH8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="171" mass="19018" checksum="EBD1947A6C08B519" modified="2013-03-06" version="1">MVQSLDTLKKARKRHVQTPVTTPKYLIALKSVTSFENDTYSLEDSVIEYVLAGDYTVFIVIVILVVCMVGILAGLIVWRRMYDKSKDCESCSTDSFVIDGDIGGSISDKVDDGEIDNIVRDSENDIDNNIDDYKNNDTVKNYEIDNGRCVDSYEAGGIKNNISGIDGLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTL9</accession>
    <name>L7JTL9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2694"/>
    <dbReference type="HOGENOM" id="CLU_3360013_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTL9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4014" checksum="78C01B3EF3468FD1" modified="2013-03-06" version="1">MESKSEILQMRPFGFSNVVVDTSFSRIANAYDSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTS1</accession>
    <name>L7JTS1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2185"/>
    <dbReference type="HOGENOM" id="CLU_026126_10_2_1"/>
    <dbReference type="InParanoid" id="L7JTS1"/>
    <dbReference type="OMA" id="IDVKCAC"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02066">
        <property type="entry name" value="GRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="68" mass="7744" checksum="4CED6AC3E78DF884" modified="2013-03-06" version="1">MKDCEDCVEAHKLMKEKNIDVKCACTQTNPILIDEIEKKHGHKTFPIIFVDGTFIGGYSDLKKKYGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTT9</accession>
    <name>L7JTT9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase C</fullName>
            <ecNumber evidence="1">2.7.11.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.13" evidence="1"/>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2351"/>
    <dbReference type="HOGENOM" id="CLU_2293656_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTT9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="101" mass="11623" checksum="E6EE897B7097BF5A" modified="2013-03-06" version="1">MPDKSVDEKMLESLEALLPKLSGVQRESAQYRIKMLKNKISEASNHENIGLEQVVTTYEFTQKLKKENNLIEGYNKIMSVDSSMKEVLLKKNSFVRTKLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU43</accession>
    <name>L7JU43_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2834"/>
    <dbReference type="HOGENOM" id="CLU_073160_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU43"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="266" mass="30592" checksum="85176066729CEDFE" modified="2013-03-06" version="1">MTSHSDCGARIASLGQQPMAIMKELKSLKNVLVNENYQMTKSMSEVSNKVNEKANTFKNFNAFNKRTQEIEIKIRETNNKRLRATWHKSPEENEKNTLKKRPEEKKLMREKKPRILNGGPIQEVSKVQLKHFCGLGRNRPSNIRRLLRDGGIRSGSIVHVGFDKENRLEILAYVNTIEQIRKFLLSFDGVCQENSRTVVGGLDDENLERLRARMECATEQKDATPPVKRFSNIFKRFLKEKKEEDLETLIYTVRSNEAGTDSPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU46</accession>
    <name>L7JU46_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2801"/>
    <dbReference type="HOGENOM" id="CLU_2559918_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU46"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="82" mass="9773" checksum="D652910B6E098A69" modified="2013-03-06" version="1">MSREQTQSDQSTLKDLKKYIKYEKRITNTYCLEKCLYELHLNIIQAMIIKKRIEKSITLLRLKRIIVFSMTCSIALIAMFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUA1</accession>
    <name>L7JUA1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ74999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUA1"/>
    <dbReference type="FunCoup" id="L7JUA1">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2041"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUA1"/>
    <dbReference type="OMA" id="EEHEIRY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="323" mass="36423" checksum="0C90C80F720678F8" modified="2013-03-06" version="1">MEYNEVSVDKIISKLLSVKNSRLGKNVHLSESEILFLCEKTKEIHLSQPMLLHIKAPIKICGDIHGQYRDLLKLFDFGGFPPDNNYLFLGDYVDRGKQSLETICLLFAYKIKYPQNIFLLRGNHECASINKIYGFFDECKRRHSIRIWKNFTDSFNCLPISAIVGERILCMHGGISPELKNLDQIRKIKRPTDVPDDGLLCDILWGDPEPSISGWGENDRGVSVTFGADVVKEFLDSNDLDLICRAHQVVEEGYEFFADRRLVTVFSAPNYCGEFDNAGAIMNVDEDLTCSFQILKPTDKLSPVSDGFIGMADSVSNSTTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUH9</accession>
    <name>L7JUH9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993986">
        <property type="protein sequence ID" value="ELQ75138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1923"/>
    <dbReference type="HOGENOM" id="CLU_3015875_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUH9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6414" checksum="72FB13B93DC1F7E1" modified="2013-03-06" version="1">MNYHSIKIPEAKSFLGYSWKRGHISHNLHVRVTVAVATCLSVVMRVRAKLLREATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUU3</accession>
    <name>L7JUU3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Endonuclease/exonuclease/phosphatase, putative transposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2288"/>
    <dbReference type="HOGENOM" id="CLU_124781_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUU3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="133" mass="15287" checksum="1906856892BEA0D4" modified="2013-03-06" version="1" fragment="single">VSDIPWRGVARRNALDRLCNFLHRERDRGRFSEIVVIGDWNGVPSQTHRHLHARQVATNEEFLGFTWATRFAHALARRGRCIDYFVSLNNAIVGKQRVLRDVDLSDHYPVVASLAVKHITAAPDKLIYDMLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUW6</accession>
    <name>L7JUW6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1759"/>
    <dbReference type="HOGENOM" id="CLU_1598551_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUW6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="17693" checksum="38F0471240F0EB29" modified="2013-03-06" version="1" fragment="single">VAIMKDGRGTKEGESMITTGMAGQIASDMVIRTENTIEDSTGMILVRENGEAMMKTVDEELPMKVDMSQGMGSEIKETVAGTATDTKAEIDGMILVPTIDVVIEDSEVGKILAEGAATRMKSDEADLVGVTMTNVEVPAAVMTEEWATETLDVTMIVSGLMSVIEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV34</accession>
    <name>L7JV34_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2537"/>
    <dbReference type="HOGENOM" id="CLU_1134236_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV34"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="245" mass="28384" checksum="24A8A59BF59569FC" modified="2013-03-06" version="1">MFIMIPRNGVFLGIDLFVNEDGSSCRAVISVNDGCFCIDSITLNFRIECRTDANHMHNNIQVYARTCLDNIGCFNLDMDGVFTIPKPLHCSHKWIRIKPPIYSNGIEEIIRGVNKIWEEKELKLEDQRIFMCSKCDRARLLVDDESELKKSNEFIPYHILREIFGHTNLSFEMMTCILLDMNQSVTKFIKCYIEKNNMKVIAVGFCISSWLYPGILPHEQPDLLVNVRRVSMLFLLILKRPGQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV64</accession>
    <name>L7JV64_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV64"/>
    <dbReference type="FunCoup" id="L7JV64">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1670"/>
    <dbReference type="HOGENOM" id="CLU_026126_7_3_1"/>
    <dbReference type="InParanoid" id="L7JV64"/>
    <dbReference type="OMA" id="IYIIGKP"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02066">
        <property type="entry name" value="GRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="103" mass="12120" checksum="B23E007D081BEACD" modified="2013-03-06" version="1">MPKLFPYKRMSVPESRIADIYIIGKPDCIFCKKAKDLLDKNSLDYEYYSSCTESKYVRNIMEKLDYHKFPIIFYKGDFIGGFTELNEKLASGELDRLGYDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV80</accession>
    <name>L7JV80_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1818"/>
    <dbReference type="HOGENOM" id="CLU_598770_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV80"/>
    <dbReference type="OMA" id="YELLIEY"/>
    <dbReference type="OrthoDB" id="10309540at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="472" mass="54170" checksum="912FBB46B1D049E4" modified="2013-03-06" version="1">MENATNQGEFKLNVATINKILNMNENVSDVAFTHVKVSTGSYVTFNEKIKQLSIKFSEGLFNLEPYIGQKYRFNKKIAIEILPVENSVANLSKIMMRNFKFTERVKLSDNYERVELNHVHTTGDGEIILNKACKKLNICECSVVINARNVKDLKLLYIQFSITEKNNIKFIGLTSVNHMCLTNICQCVDSIITMLTDRCEIKHLTFENKYAYETSELFSEYYSGMLRRLIYQEKYQSNLSAKLKCLVAKDVNSSVFMYTVPNAVVNFILHEILGKGGMTTVSKLEFISVAIDVNSCMMLRKLQNLTILRICLANITSRFIYNLPTNLKLLDITDFSSENVSWATKYAIKPAVIIRSQKRLEVLIVDLQFLYNFSAISMRFPHLKVLKVRYSQSTIIHSRMQGNKMNVYELLIEYNADQVEAYQISAISPEMVYLLENLKLYVDFDSLDCLAFVSENKSVVIDPKTFKAKVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVA7</accession>
    <name>L7JVA7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Hexokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1848"/>
    <dbReference type="HOGENOM" id="CLU_1312818_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVA7"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="1">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="210" mass="24299" checksum="938D8C27C3208E77" modified="2013-03-06" version="1" fragment="single">VDPHIYIWMEENSNNSFYYSLSDMKNLKNSFRDTIIENRRVKNEKMLFPTHLYIHNVSSNNKSSRIDKKSHSSSNLLEHEKTFEPSCGGALIAKPVNLLCPSDREKKVLAIDLGGSFLKLCVYKLRNDEIVSHTQLKKYKISKDGSLSNVSMFDWIAAKTQDFLMGEFKEKTVCIDKSNLTLSRLIDDEFYEQYDSWNDNFLSNTTLCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVB6</accession>
    <name>L7JVB6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein AARP2 involved in 40S ribosome biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVB6"/>
    <dbReference type="FunCoup" id="L7JVB6">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1858"/>
    <dbReference type="HOGENOM" id="CLU_299007_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVB6"/>
    <dbReference type="OMA" id="DERYENV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AARP2CN" evidence="2">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="3">
        <location>
            <begin position="351"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113501" checksum="65054AECDC60C205" modified="2013-03-06" version="1">MSTKVMKRKRSNKKDKKRKGNIKEKKKVIKGMYKNEPMDNNYDESSAKEGSIKESNAKEGPKTNNIRESNAKEGPKTKNIREGPNTKNIREGPNTKNIREGPKTNNIKDTILDLNPQVIQNMKYKDAAPSIVTLFGPPALLTDLQHQIISHLYKPCKNVQGPVTLRTSKTRRATFLKVSYNTMQMIDAAKIADLAVLVVNGTDGICKEHVEFITLLNAFGMPKVVVYVATRVDNKTLKHVKKVVWKEITPGIKVVTSVRMLLNCVAVFKSRPLSFKCENAYVVVDCVRVERDGMRMRGYVRGKRMMAGACFYVPGVGDVKVGGIVRVKDPCEIRSDEKVLERRKVFMYAPAVNDDEEGLHEDEDDRVRGLNQDEDGRVRGNDEGFVLYDGEKFEYDEEVEGNENVEDDEEVEGNENVEGNDERYENVEGNEHGSNNRCNSNFIPPTTSPIPPTTSPVNSPSTNPITKTNKLSFQELRKNALQKLTNNHNKKQNSTNPSTTNHPIQNVFIPGNYIEILVKTTFNHSPDSILIIAPIDYTAHALIKASFLRTKHFIHFVRSDDPIVVSAGWQRFITFPVFYRRLHGMNVYLRSSVDGCMACYYGPVCRGGVVMVRRVCEDGESNRDNNFFYNFRIVGTGRINGTISSGCDNIKDNVSGGDNKGKGSSRDNIRGSISGRDNIRGSISGKDNIKDNVSRDSKIISTPNTNPTLTTTPTNTISTTTTLNTNNDHLMYKKLKLIGNAYAIKGNTAFVRNMFNTNLEVNRFLHAGIKTTSGIRGIIKKALDKNGSFRASFEGEIVEGDTVILNTFVRMSVNELCYTVDEKVREVPKFRLRREINRDGGSRDGGISVEDKGISIKDSRSRGKDREVSIKDSRDKDSMSRDSRGRDSRGKDRKGSNNNKMSRDNNTISTTNTNITIPNRIINKLPLDKRLCYTNVVEHNNTVLSPFLKEDLVLEKEIKAKRKEMQRIAQQEKENEQRLRKEEEKERQRIKREGIIKHRIRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVD6</accession>
    <name>L7JVD6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative polar tube protein 2 (PTP2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1756"/>
    <dbReference type="HOGENOM" id="CLU_957081_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVD6"/>
    <dbReference type="OMA" id="CKIRISK"/>
    <dbReference type="OrthoDB" id="2191141at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031507">
        <property type="entry name" value="PTP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17022">
        <property type="entry name" value="PTP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013198064" evidence="3">
        <location>
            <begin position="16"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="291" mass="32439" checksum="C21F035AA173DDCC" modified="2013-03-06" version="1">MLVNMFMCFLSYAYAATVVGQSAAPQQPQSSPSTTAFTASANAKQDQAANLQQNAMLKTALNQITATQMGEGDAKKFIPGYNGKNLYCDPRGVDGNWNLINKQLQEECIKQKREKKERAEQLAKELTQPSQDDCKIRISKESMVCHARKVMNNVIKDAYYTIKLFGNVVEIIVKNQPVFMGVTERFRYNAKRLKKQAPNAFKNSPTATFKFNRLGGLLSQTGEVPQPKKNNPCAACLEMLKEKTNSVEGQANNCGGCDSMLDITTIHNGQFRIQNKEENTTDSKKKESKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVH5</accession>
    <name>L7JVH5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1797"/>
    <dbReference type="HOGENOM" id="CLU_1042766_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVH5"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="267" mass="30397" checksum="0447C5FB515C5274" modified="2013-03-06" version="1">MIFKISNIPIYFPYPTISPEQLSYIKETIASFTTTSNLFIEMPAGSGKTICILSAAVSYQLYHVEDDVRFVYCTRTVQESEKTLVELKTLIAYVKQHVKVKYMGLGLTSRKHLCVNEDVQGNIEMSCRKLLSTGNCDYYDRIDHILENVDMGDDYAGHIFXXXXXXXXXXXXXXXXXXXAEMNGGMNGKLSDRTETSTYKTGDGSAKDEDCASQPFSFDGVYTFEQIKRKGQYFKFCPYFLTRKALSSSNFLILTYNYVLDPKIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVP3</accession>
    <name>L7JVP3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVP3"/>
    <dbReference type="STRING" id="72359.L7JVP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1945"/>
    <dbReference type="HOGENOM" id="CLU_049753_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVP3"/>
    <dbReference type="OMA" id="SCKIRRC"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="9">
        <location>
            <begin position="314"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="391" mass="44722" checksum="5B92A48785385D94" modified="2013-03-06" version="1">MAPSFTSVVFLGPSTELNPICTVKYPKFTLPILNEPLLLHNLRWMDGVSTEIIVIGLERYKERVHEIVAESMCKSKITFIGLLHYDGTYHNLKKIIKDIKTTHIIITKGDIISFVKLKEIVNAFLKRKTGVFVILKRDADSASIVGYNEDSILFYNNDCNNALETKFFLEHSRTKFSVDLDIAQVYIMRVKVFEEIEGEFFSFKSNLFPMLVNKLGLKTPVRFFFSEDDVFQVQKYADLVKVTNILRERTKNLPFYLHSAELHDLTEHEKHKYVMNYNLQNKNFIFKTKNRISFPDDKNIVGRFLTTGKSYLKNATVGNDCEIGDETLVEDSIVFNNVKIGNSCKIRRCLIGSNVTICDGCVLMDCKVTSDYVFSESVNASGQVFIGNEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVQ6</accession>
    <name>L7JVQ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">60S ribosomal protein L10A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVQ6"/>
    <dbReference type="STRING" id="72359.L7JVQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1496"/>
    <dbReference type="HOGENOM" id="CLU_175756_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVQ6"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="9298" checksum="18D8D8BEAF3E6F46" modified="2013-03-06" version="1" fragment="single">VIRNPNDLQNFYNEVVRMVKFKLRKTNDISFTVGYCEMSDEEIYTNLNTGLNFLATLLKKGYKSLGGVVLKSCQGKPVRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVU5</accession>
    <name>L7JVU5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVU5"/>
    <dbReference type="STRING" id="72359.L7JVU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1624"/>
    <dbReference type="HOGENOM" id="CLU_943649_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVU5"/>
    <dbReference type="OMA" id="IRTYNCE"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="278" mass="31234" checksum="4ACC52CEE791D0B0" modified="2013-03-06" version="1">MDLSSEIISSFQKSVTITSPAIKDVSFVHTGTALAYTQGDALKIHCPLTNTPLDMIHIPDLKKMAFLFDNTILHTTPTHVKYLSLYDNTYIRTYNCEGVCDVQCRTDDDVFMCVSDRKIEFYDLRSAHPLSFLTVRNCIATLNNSCFAVLINKTLLKVFDVGATAPRLTKEVFNAHKIKLTNDNRYLVLGSTKSVLVLDACTGNELQKIFVDNLVDFDVSESSEYLFMLHDGKVSVNRITKKEMIMSVQVGEQKMIRLNPGYAQFVSAVPNLTFYAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVV1</accession>
    <name>L7JVV1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2184"/>
    <dbReference type="HOGENOM" id="CLU_1062399_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVV1"/>
    <dbReference type="OMA" id="ACRKIAN"/>
    <dbReference type="OrthoDB" id="10430415at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="262" mass="30020" checksum="4DD7235FF15955A8" modified="2013-03-06" version="1">MCVGLLRKMFINCRKACRKIANFVAPSNNNKDDIRSSEEERIVQRSKERIVGKRNREKSINKTESMGAGSVVIDSDISSMSGISESKSDLRDERAAKTKKIKYSKKDGESVKEHNRVLADQISDDRSSLVTLSLLKCEEVAKYEDTDNKVKKNVLDTRNDRSIHETNKVSQISVLRNKIPFKKNENYRSSSTTESSSNISLLPSDNEYEDMKPTINFKNKSDYSDLIENYENSGEQKQIIDKMKKFLKKCDRKKEKQEIGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVV3</accession>
    <name>L7JVV3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1634"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVV3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="889" mass="102811" checksum="007B6B5F20C54777" modified="2013-03-06" version="1" fragment="single">VSSFNAETTKYPQYKIYDYDVGQNSTRTETTDGMVGIRDESVALSEAEYINKKPYFTYHDAIQAENNGKKKFKVIEIPYNKILFVKLVNLTSSKITTFSPGEINTIFSHVYLIVDDNFQLMRQLFNNFQKDPQILLSLLDCHKEIRRHKRSHQASILKHQDFYSKALEQFREDVNCLITVFLYHEPNFSCLVHGRKNKSLNGASVPLRKFNVSFLFECLELDIRLLVNNVELIYEKFRYNYHNSALDIIVRGGLSPTMISDMARELPFVDFELLKTSEYNLWKLPHVNSIVLKLWNDTLTANHTYTNLLSGAYYIYYVVELIDWTPSNINEITVCLKDTLDENINRISINITHLKCDNITFNRDFIFERRYQSIALKNCKVEDTYCVTFRHKYEKISLSLTEGLFNLPEICGLSRVKLPNNEPAYLRYEIHEKDSETLFLTSVHIIGDIVMDGTLSRLSFLQTIIVNTLTIRITDTLKHIAIIYCLGKIRFVGIFAANFYIQTKSYLKIDMNDNLCKSMILVNFVVSEIIVLPEKFYKITLVNVRLIDNSCVVINGNCKEVVLNHCIGSFDLTKTHQLDQLGVIFSSNFADMLLLIGPITVGSLVLRNIPCNIIELKVFFGTFRSIKHMTIDFSSIAAKYTSLENYLANKWQEIMVRTTISENPINQPMTDDNTQNFYDETVRQVIAETFLDVIFNEAIAAGIERLKYSNVLMSNLSLKYLRRLTNLKALEAPMKSLSDDLFTYLPVSINLLDLRNSERCNDGYELSFCTLSNLINLEILFVECWLLRNIQFFDFIPVSVNILIISYQGTHISYESTTDEKIKLRILKIETSLSPIHDDDTRISNQELQHLLNQLFTRISRIYIECLAIVTPFSYFTVDVSDYKIIIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVW5</accession>
    <name>L7JVW5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1434"/>
    <dbReference type="HOGENOM" id="CLU_768490_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVW5"/>
    <dbReference type="OrthoDB" id="2187331at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="361" mass="42503" checksum="926CDA5777EFF72C" modified="2013-03-06" version="1" fragment="single">VLNPLLYNFTFAQYRTILKNIVKTLNAINISAFINLFVRFSLKYEVNSIKFLLENIKHHDVIVNELNKLITVERSVVLFLFYIEVISRMDNVQNVHEMSRFVFNVLKVYLGQDVRRRPIQRTSRENVAGTGCIGGSVRTDVVEELYKRQIVRSNRFYPCIKKYVDAFLAKVQHKADVLYFFLKQSFQYDFSQSEKTMTVYSRDFQDLILSFVSNTDVEVNLKMIDLLLHISEVVPRFKDTVFNIVCKFRLCTYTTDMRGRHAIMCKIRMLYARMHDDRLRHLLELDDREKIANERLFMAVEAVRNGNVPTTAYDMDSDVIDYEGYFGWNKSYASSLKSSLNFESISSKRRSFLRNMDVTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVW8</accession>
    <name>L7JVW8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative polar tube protein 3 (PTP3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993942">
        <property type="protein sequence ID" value="ELQ75574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1479"/>
    <dbReference type="HOGENOM" id="CLU_247878_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVW8"/>
    <dbReference type="OMA" id="RNKRANC"/>
    <dbReference type="OrthoDB" id="2190813at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1518" mass="159209" checksum="FA2A5F7AC6AAE09E" modified="2013-03-06" version="1">MGGYPGGMAGMAGRAAAGDPYAQGAMANEAAMGNPAAHQAMAGQAAGGNGGATGALAAQAGRGDPFAAAALQGQAAGGNEAAQGAMAADSLMGGPISQMRNAQRANEAGNAAQQTPVRANAQRAMRPMSAMTDDASRKAIAQQEAMNRLQQNRNPYMNNAAAGDMNAAGMSDAANAAIAAEEEADALLEDVPPGAMKAAMKAAQMAKKVGPAAAAEAESLAAADPNVSPAQAKAAGAQAAADAERALEDYAAQEQEIDRQGSEREAARQAGDMAEEMMARMNPQSRPSERAAAGAQAAAQVQQAFDKQRNAEGHMENMAERNAQRKAANEAAGEAAAGDAAMGGATPEQAEAAGQQAAAASDALNAPGRPEREMQAAELGAAAASQMNPYITPREMRAAGIQAAQQERSRPGSSPGSLMRAGMEGAMQQAQADGTRPYMSPREMRQAAAEEGAAEGVEIARRIKQRPLQRAAAEGAAQGVAMARKMKQPARAMREAAEEEAAEQLAAEQAMADPRLSDIAAAEEGAAEGRLLGEAMKHPDLVKALAEGEAEGHALARKLGPPTKAEAAAEGAAEGEALGKALKRDPKLNAAAAAAEGEMEGRKMAQSMKRPGELAQAAAEGAAEGIKMANAIKVPAQMARAAEEGALEGQQEAQRIKEAEMEAARKAFENDPQIQRAINDGAAQGIAAAKAAKQAAATGRNPMEAAEEAAAKEDALQQVARDPVAQAAIAQDLAEEEEEIEKLAETVPEAAMKKALLQGASPEEAFKKGESVAAKNVINNAKETIAKSKPYLQPSEAIQEAQESAEAARAEGFIPKDEAAARVEQAAMDAEKRAAMKAAEPSTDSPAGLGIIATVPDDAEAVRVKNSSMHLPMKSFTDVEAKSEREAEALARQNDLKEGLRNKVTKNPIDSPLNMIMGEDGYYNVPESAKELEITKGRAIFPESAKESMKNAGLDTSTLQHKINTGERKDMGIGLGYYVADVSGMHMDVPSPSNPTPSKALVGEKGALDTSLATGLDIESGVVKMTPWSEYSKRVRPRLNQGISKRPRMSAADEKMLKKALETRDLLQNTKTEVLTNPNGEDYVKVTPPYGVPEQVAVADAIANLNGKPKSKKSSGQDGVSLLQGTDSIGFNLEDALEGSGSMNIAEKPDLTGSVEDQVIGKSLNNAAMSGTAKDTMTPVNAFTGLVDLEKKSIVAPEEERPKPSKDQSKNDMVMNELKYDTPTKAKKLNVGESSYISAVNKLPPDLILFLIDYAINPHDSSLKALHEKYLSMLASLLPNKSEAFEGLIYEAIKKQIGLANPKNLYTAPIKEVTKVVYNKERPNEPPKLQKIFVDKSPTHKVEPMYVPKKEMIKKVNGKVPDLKIKEETKKEHPKVVQITGVRKVDANKVPRERMANAKTVEVVNKQKAQGNVPKQSSTTNVQQVPASPPKTTTSVIRTGPANNQAPVSNVPSGPPTGTTPAHGSAPPMTRYESIPRGYRIVRQVPVNPAYVQKVVNGKPGPTVVAVSPANNNAAGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW93</accession>
    <name>L7JW93_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative component of NuA3 histone acetyltransferase complex</fullName>
            <ecNumber evidence="5">1.14.11.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.14.11.7" evidence="5"/>
    <dbReference type="EMBL" id="JH993931">
        <property type="protein sequence ID" value="ELQ75733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW93"/>
    <dbReference type="STRING" id="72359.L7JW93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1312"/>
    <dbReference type="HOGENOM" id="CLU_816288_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW93"/>
    <dbReference type="OMA" id="RIVIFEV"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019797">
        <property type="term" value="F:procollagen-proline 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="4">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="361" mass="43163" checksum="6D4722F12C57AF95" modified="2013-03-06" version="1">MKTNNFPFVHVVIDNFLTEEEFTKIDEAYKNIKFYEKYTDLYHFFQSEELVGLEGLSFFKNKIYRAIKQLEEHDNFQNNLLCEKSTSNNAQGLLSNESKYWFNIFASYYDTGHYLLCHDDLIEDRKYAFSFYLNDFTSGELILFNEKANEEVERIDVKKNRIVIFEVSEKSFHEVNLCTQSGRKAFTGWYNINMKIERASKTFEKKKNIAKFEYVDICDEIAGDCMLMEVGDYDFEWKSKELIGPFTEQRVYLLEMQEVLVPIISNLKFIECDFYEFNANNYILVKEREQGDYYDMFVMKYIDKEIEGKEFITYIDKNGNAVFSLKFENESLYLVKRNGLNFFVPRTNYSFYLAHFVFTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWC5</accession>
    <name>L7JWC5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="4">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="4"/>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWC5"/>
    <dbReference type="FunCoup" id="L7JWC5">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1296"/>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="InParanoid" id="L7JWC5"/>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000122">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="234" mass="27020" checksum="3F90E3D016CEE733" modified="2013-03-06" version="1">MYTVIVPTYNECGNVEILCNFLKETFTKINLPYNIIFIDDASSDGTYELICQLRNEFPILAIRRTQKLGLGSAYKHALKYCDNSEFVIIMDADLSQNPFDIQNLIRVQQKYNYDLVYGTRYNNGNVVNWPFLRKVISRGANNLAQILLGVDITDYTNSFRLYKTSLLKTIAPRVKSDGFAFQMEVIYRAARQGFKIGEYPVIFHDRCSGTSKMKFAEIFWFAKTLLTLVLYRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWE6</accession>
    <name>L7JWE6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pantothenate kinase</fullName>
            <ecNumber evidence="8">2.7.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.1.33" evidence="8"/>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWE6"/>
    <dbReference type="FunCoup" id="L7JWE6">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2001"/>
    <dbReference type="HOGENOM" id="CLU_912724_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWE6"/>
    <dbReference type="OMA" id="ANRGDHR"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011602">
        <property type="entry name" value="Type_II_PanK_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036940">
        <property type="entry name" value="PanK_bac_aCoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978824" evidence="7">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="305" mass="33567" checksum="A1B305E21DAE115F" modified="2013-03-06" version="1">MLFHFLLIAVSCAKPMIGIDFGGSLIKCIEIIGDDATFIVMKINDISELKEMLKRKKHARLTLTGGGSYKYNFTPCKNILPEMEALYLGYKYLIRHNAQQFYTYTPTDMKQIQIKPSNECILVNIGSGISIVKLTKTRFERLGGTTIGGGTFTGLGRLICGETDVDTMFHMASLGNNFGVDLSINDIYGNCDTQQMLGLAGDLVASSFGKVSLSSDTEYNKNDILSSLLSLIVNNACLMAISHAEKQNQQRIVFSGCFSSQAIVRERIVYCFHALKKTSIQPVFIAQAGFLGAFGCINQMISPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWG5</accession>
    <name>L7JWG5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD box family helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JH993921">
        <property type="protein sequence ID" value="ELQ75813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWG5"/>
    <dbReference type="STRING" id="72359.L7JWG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1226"/>
    <dbReference type="HOGENOM" id="CLU_1922208_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWG5"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="132" mass="15116" checksum="198090D9771F8CD8" modified="2013-03-06" version="1" fragment="single">MVLAHTEELIDQAVKKIRLMNPGLKVEVEMRKLKASPDADVVVASVPSLVRRRRFEKFDPMEFKSIIIDECHHAPAITYRKVLNHFKALDSNLTISVIGFTATLVRLDKQSLGHIFDEVVYERSLKSMIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWI1</accession>
    <name>L7JWI1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1609"/>
    <dbReference type="HOGENOM" id="CLU_486783_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWI1"/>
    <dbReference type="OMA" id="MIVTVTK"/>
    <dbReference type="OrthoDB" id="10294302at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="560" mass="64194" checksum="5F3037281BDA7D56" modified="2013-03-06" version="1">MIVTVTKKDPFYRKIMLILAILVGGLILLLIGYVIWRKENKLEKKITESNVNGKLNVSETKSDDISQRGVEGINNVSIPHTSTEEYKSMHINDENSCNRVLGCVNKPSDNALNGNNESENFEGARCKETEKVSVNHRDEAMNKNTESVEPNDAIDTANLKSNNNDKPSGNKTSSILNHNESDLREVQVSMNTDTLIKESEDITKGCSSLQEKYQINEKSNNHHDVYVKSETTRNDTDTPEETYTTNISHVNYEIDGKDMMFKDQQMQHDNIMEDTIVKQGVYSHSSPLNETAGAERYSSNGLGYNSSDLLINPHSQPRSTHNEMNYNNTDYINTCNQINLLTNSNLNELEQFAYPNMATYNDQSTNKWYKNDEIMQNEQLSNGKKSVIPNISLKNFERQNNEVKRVKASDLKQFDIQQHLYRSNDKRKNNDASLMQVRAPYNNFPVSNYNTITSFEDEFPLRQEFFPTDETIDEEDKIQKPVTKNQSRIGKKLINFGKKLHKSFANLSSVGKNTNSKSPNRFENEDNSYLRHKNKSDRLKKPKKYDRKSRSVSDLPNLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWU0</accession>
    <name>L7JWU0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1293"/>
    <dbReference type="HOGENOM" id="CLU_855796_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWU0"/>
    <dbReference type="OMA" id="ETEVMIY"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="325" mass="38857" checksum="072131E8CD1A165C" modified="2013-03-06" version="1">MATKGEDDNEITRYILYGYIGIHIRKINITERQKSAFAKMSFLTPLQFECLIKDVKTEINRRITKREPADNDNIRLSNLSELKFRDLVIDLFLVFNKKFPSKRYDNTDETEVMIYNLENLIHSLKNENEGVMKNLRMISSVFKRIRLYQKYLKSEFTKQNKNTQIIDYMDTVFDSHDCLLLEILNNPDYMTNIADRKLKNNCYYENIRTKYKYEQNLSEKNGQKDYVLKVIELLLFNKSYDQETDEALYLLKNYEKIDKDHDNRLELLILRLYDQAQRLGFSEKAEKLKNMKVPVEKKERGDMVCFLAEVLRNIIIKDRNIGNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWU8</accession>
    <name>L7JWU8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_1236</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWU8"/>
    <dbReference type="FunCoup" id="L7JWU8">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1236"/>
    <dbReference type="HOGENOM" id="CLU_013993_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWU8"/>
    <dbReference type="OMA" id="NIAKCGY"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="585"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="772"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="179"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ75775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="934" mass="104068" checksum="108B924D54B53A9E" modified="2013-03-06" version="1">MQQNNTFGKKTINGRENKRGGNTRNGHAVSSARPTNNDDDNNKAVRNEHLNTDKLPNTGSKFDSTTGIKASNDGTKELVNTEFMQNNLSHSEIMRVDGSRTQLGKNYKSGDRNSCIDERVGLRVEERAVRNGTGDGMSGGLGGDRPLRDGGVMSGGLRRDSGKLKSSRNNGKDLKDGNGNDNGSINTNSNGNINNNNEDSIKNNSNTSNSRGRNASINNNNTNNEDIINNSNTNNEDSINNNSNTNNEDSINNSNINNEDSIKNNSNTSNPTGSINNSNTNPTSTNNNSNGSRRNDDRPFHSGRDQYGGDLRSRGRYDRDVRGRGNVIDNENRRKYGRNTDKNGRYYDDRTSYGNRNAVRNTRPYNNAGDGQSDSRRGNVRNVKVNDSCTNDSSIGNKEVHGAEYKKPFAHKDRRDLDSRSETVLSSSVEQRGIETEYGTAEDTSKTESKELIMNKEGVTRNGGNAGETKLDNNVDTNETREDRGSTSSMSTFTSSPTESPSDGLSNKPPEMSHKSRLMKSLFKNLKLAEEKYGIDVLNEYKNVRRSDDVSEFKGVSWDSLGLDGRVVRALDSLGYKYPSPVQKQVLSTSRNNLVVRAKNGTGKTLAYLLPILNNILKAEESKRVKTIILVPTRELAMQVAKVAKRLATHFDKSVVLMPSYGGSNLYEDVIRIKAGIDGIISTPGRILDLIERQVLLLGSVNDVILDEADKLLSLEYKDTLRKILRNINSRRNVYNLRLFSATFPLPVNDFVERNMKNVLFINLMKESCLLALKQYYCCVKTEYKLHCLITLLRKVKYTQTIIFCNRTKTAELLAYRITELGYSCYFLSGKMTQDERNTIFYSFTNLKINILVSTDLTTRGIDVPGINLVINFDWPRTIESYLHRIGRAGRFGTKGISISLVGDDERKEVGRVESALSCELLPVSDPSFNGYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWX3</accession>
    <name>L7JWX3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWX3"/>
    <dbReference type="FunCoup" id="L7JWX3">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1261"/>
    <dbReference type="HOGENOM" id="CLU_035750_3_3_1"/>
    <dbReference type="InParanoid" id="L7JWX3"/>
    <dbReference type="OMA" id="KQHLFRH"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="267" mass="28919" checksum="5B82956E599512F7" modified="2013-03-06" version="1">MNSLNQKIFRTLMMNDSPSSTAHPLDFNSFSAQAQQKRVTKTGTTIVGIKSEHGVILCADTRATSGPFVVDKACFKLHRISDDIYCAGAGTAADTDRVTSYASSMVRIFETKYSRKAPVKYVISVISKHLFQYQGAVSAALIVAGRYKSTYHLYSIAPDGTVNPGFYLSMGSGSLAAVSVLEARYRAGMSMHEIKELGACAVKAGIMNDLYSGSNVDCVVIDGTGTNVVRNFLKVAGTMTGKRIAYALDSVKVKKEEVFEIVEEVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWX4</accession>
    <name>L7JWX4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone deacetylase complex, SIN3 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWX4"/>
    <dbReference type="STRING" id="72359.L7JWX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1845"/>
    <dbReference type="HOGENOM" id="CLU_015977_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWX4"/>
    <dbReference type="OMA" id="DRHINAK"/>
    <dbReference type="OrthoDB" id="2189905at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="5">
        <location>
            <begin position="480"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="889" mass="104019" checksum="1B397B62F238F5C7" modified="2013-03-06" version="1" fragment="single">VSIKLRRIFIIYKKSVYPYRMTVEKKEKKDESGFQQHAGGYGREGGYHPGSPRHSMAKNEYAMPYTNSPAEKDMKEIKEGGYPREGGYGNFVYGKDAGYGAAMGERMHGNVSAHNTPSHSMTNMPGANSGHSMPFNMPHPSYPRPYPYKEYYQRRYNDYQKDFIINKKKEDLNLNDAISFLETVKTVFADDPSIYDSFLEVMRDYKHGKIDAGGVVRAATTLFKGKPDILEGFNDFLPPEYKIDRGNRRRMRMEPPGRPIERMNERFMPGHERMMDRPDRMGERIVPDRAGERPIPHDRVLPKDMPKVMDAKQFVPGSNPPLSAWDGQQAEEQTVALNFIKKVKSKLNNMKLYKEFIEALTHYQKTKDELVLAKIKKILGDNRDLIDEFLTFMPKGEDSALAEVKKILEAKNVYEEFLKAMNLFNQKLMEGKELIFFLRAYIKDEKMIEAFKEHLGQHNAGLFESKGDKFVNTEDLGGILGSYRIYKDKGFRSNQDALSKQVLNHVCYSFPLYASEEEDVQFKRSAYMETLYRLEDERYEIELLIERGESLIFSFEVFLNSERSASAEKDGDGDEQLQDELDLSQLHMPAPLVNEMILFIYGDRGEEIFEELISKPRAAMPVILKRMYKLIRYWKLELREKEKLWKDTNERAFYKALDFHLDFKAIDKKYLNFRNFSKHLECDIDVSGMECMKELAMMLYKLKHDDDSIDDVLKIRNGGASAETAIRLRYFYLLMERLAEIKDKPFFMDVVDLLKGHLEAPVNDFEEKLRIVSKAQAYKLATIDKLLDKINKREHGHDEMYEVLLGDRLVIRSKNEQDEYAEKYSTNDIDNAFVRDRVFMNRNLRDQRFCFSYRITVKICRKSYKIKYSEDEIDYIFRKGFCRVVQTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWY0</accession>
    <name>L7JWY0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993942">
        <property type="protein sequence ID" value="ELQ75566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1470"/>
    <dbReference type="HOGENOM" id="CLU_3227277_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWY0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="4987" checksum="C3EAA12AB050449C" modified="2013-03-06" version="1" fragment="single">VTRLYVIRLSTASIRRCCQRKCPLSGPRGLPTRPVMCKEVGDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX29</accession>
    <name>L7JX29_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993912">
        <property type="protein sequence ID" value="ELQ75860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1174"/>
    <dbReference type="HOGENOM" id="CLU_466286_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX29"/>
    <dbReference type="OMA" id="LITHKMN"/>
    <dbReference type="OrthoDB" id="2191863at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="585" mass="67130" checksum="EF796F14F403E9D5" modified="2013-03-06" version="1">MFNRILLGKKLPKYADEAFYPTSTPPKKAVIGTHNSSAVFCEYLCSANARLSVKSLRKMSNEWRFGVYVKALGVSGSVLSYGMVREYDRMVVRWLVEECRARISVDREGVVERDVFKIYKCVMEEYHRRNDGKGGGKDRKERSDGKDRNDRSDGKEGGKDRKDKDRKDRNDGKEGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGKERKDRNDGKEGGKDRNDRNNTSPKKEEQNDENQSNRYNTLIKNAKDDDHYNNEDALSLLPNTLFHKPLITLITKLLDLPNSTPPLTLSLINCIVLDLKLLSYHHQKYITQENYNVFIKELIRTDDALFTYLDVLITHKMNSCTLSNVIAREGMDMIRYVKYHLLDKEINNEVVSVSEKVNVKEEYFDFLVVENQMIEAQVHMRETFLEEIKGLKRENARLKREIERMKGDEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX69</accession>
    <name>L7JX69_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX69"/>
    <dbReference type="FunCoup" id="L7JX69">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1022"/>
    <dbReference type="HOGENOM" id="CLU_027721_3_0_1"/>
    <dbReference type="InParanoid" id="L7JX69"/>
    <dbReference type="OMA" id="CFVVMHI"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF147">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="308" mass="35855" checksum="BA006CDED80F2C79" modified="2013-03-06" version="1" fragment="single">VLLLFLMPSTVYASFVNSILSTLYPILTIYSYYVLVGKYCIDAKRFDTVVVLIMFLIYHVLLIYTLIFYMRILAIDDTSTSNRFPSKVANKQAITSRYFNPFIEEEIIQKRLKMLKTCPICVTYKPPRTHHCSICQKCFLKFDHHCGLLGVCIAFHNYKFFYLFVAMNIIYCFFLIVLLMFEVIRNHNLPTASLVHFIVLISLLFIEISVSLHMFIHHTLIILKNETTIENSALNAFMKGDQGVRFIYQEGPLVNEEEVLQRDDMNPYNIGVNENWEQVFGRNTWEWFLPTFTTPGDGINFPKKIAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXA9</accession>
    <name>L7JXA9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Origin recognition complex, subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993898">
        <property type="protein sequence ID" value="ELQ75950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXA9"/>
    <dbReference type="STRING" id="72359.L7JXA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1087"/>
    <dbReference type="HOGENOM" id="CLU_665987_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXA9"/>
    <dbReference type="OMA" id="FINFEAY"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="471" mass="53760" checksum="A065FC584489F16F" modified="2013-03-06" version="1">MVILKNGDDRHVNTSTAPFIRVSQRVHEQNMLLTYIKDFQTNGKGHVIYISGVPGSGKTYTVINTLLHCNKAFYFNCGSLKNKSTFFKRLYGLVNSGTGMTGCKYVVNGGNSVKNRLYDIENVKNKLDNVENEGNKCLVSNKKTTSTNVTYRNTNSRKRTKQPFTMSNLTSKLTNRILIIDEIDYLLTRNQHVLYTLFEMKTHTLLICISNTMAFTNKLDGKITSRIDFFINFEAYGADELREIVGVGRDDAFDLVVRRIAAVCGDVRKVEWYKRMLKRNGYDEDNDGRNEGTGYDEDNDSEYKGNDHNENGRNKRNDCDGNSGSKNGENSYDKDHIKNEDASKLGNKITRKKGGTNKDRIGSMQNNRESKRNTMGNTLNGETRAVKTDYKKQNDMKVIDQLMKSDKPVFSCFLNEIDEQKKMILRMGVVKYEDVCGMDYFEYERIVGELEQMGLVVNGKVVLTREEIDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXB1</accession>
    <name>L7JXB1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small Conductance Mechanosensitive Ion Channel (MscS) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1684"/>
    <dbReference type="HOGENOM" id="CLU_032061_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXB1"/>
    <dbReference type="OMA" id="NMTRAPE"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="547" mass="62446" checksum="83804A3F77A4DEB3" modified="2013-03-06" version="1">MEDFNWYEDAAEIDVEEFEPVEKDRSQISKFFDLVKKIFNYAILICGSVYIFRYIFNKHKLNILGVSLDMILLCIIIGCGSFNLVVLSAQIFHQLLKKLGLKVVEKRFKSIYRWLSVTVWFLLCLYFLKYVKDDLNIYYRYVKSFVLSGILTGTAFTGVALAMELFYESFVTSSLLAKMKEVDMKEKIVSAMKSYRYELSESSTTDAAGCTFSEIFFGREAEANSDTNVSHINLNRGNEAVIGNVCFKSPEIHSLHDAKTLAKDVFEKATSQKEMSFNEFADIFPNAQIAIQAFAYFDANDDRTVSRKEFKDTIIQFYIDRVNLEKGFAIAKGFVDIVNDILSIVVCGFLILAYLVIFGIPLKELLALALSSALVLNFAVSGMAVDLYFNFMVLLSHPFDIGDDVIIDNTNYTVYKIGLNSTSFLGRNGGKVKFLNSVLWKKTLINMTRAPEKVLLFTFKLSSDVDADVFRNLKSRIHQYLKTRKFDFFEAFSLEAISEEAVDITELDCALILRCRSYKTKARKFGLRVEINKFLKSLFDDMGVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXD8</accession>
    <name>L7JXD8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="6">dUTPase</shortName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXD8"/>
    <dbReference type="FunCoup" id="L7JXD8">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0894"/>
    <dbReference type="HOGENOM" id="CLU_1994208_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXD8"/>
    <dbReference type="OMA" id="EITCIVQ"/>
    <dbReference type="OrthoDB" id="10261072at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="7">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="125" mass="14024" checksum="774A9C9B9C803818" modified="2013-03-06" version="1">MLEAPTFSPAMFNLVLSSETAIPPKKNSHSHLLYASETTVINPKTLTTIPTGVYLSFPPDYFLYISSLSHKFGSNAHVIDSDYRGEIFHVVRSKSDESFVVEKGEPVAQLIFYKIVLPEFEVIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXF4</accession>
    <name>L7JXF4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1383"/>
    <dbReference type="HOGENOM" id="CLU_1817151_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXF4"/>
    <dbReference type="OMA" id="TAMQSKF"/>
    <dbReference type="OrthoDB" id="10413685at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978948" evidence="2">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="16889" checksum="6DB751202712374D" modified="2013-03-06" version="1">MRVKLTHIFFFLLALHCATQTQQQCDYRKRFYDLVQTAKDYYTRSMVYMISLKDDAVRRATTEYEKLKAKYKKASEESEVKKEEQSDPTDELRQLLEALTAMQSKHQLNTEKTIKAKDDEEATENAEEEKERKAESKEKEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXG7</accession>
    <name>L7JXG7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993962">
        <property type="protein sequence ID" value="ELQ75447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1604"/>
    <dbReference type="HOGENOM" id="CLU_550520_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXG7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="496" mass="57172" checksum="52E70FBFED7AD78A" modified="2013-03-06" version="1" fragment="single">VIGNNCKDVNFDFCHASVDIRSIIKGVTADDSVQVSPKTHCRLENYWSATLSKLEVANLQLNGTCRIERNANFLSISNFYFGQYSTLILNENVESLRIKRCNVNIDASQVKKLVSLTLIEASTLIYNPQVCNSLIYFEVFKMEIDNDITFTEGLDAIILNDIKIKGKSIVKINRNVSYLEILNSAGVIDMKGIAGFDLLEFDEMNVFTLKKLKRSEDRFILYLQHFYFMSDVRLADNVEIARLKYVDMWLNHKVILGKGCKCLKLTLFDVKIDFSFCVNLKKIILKDMPFYFLKKLLKQSPRIDTLVLQKLTIEDKVILPNCIRIVVLQQIKMIYNAKLIINRDCREVNIVHCSGDFDLSKITKLESFMIINRLVNSSSHRIDLPSFENIRRLETSYNINSVKLQHLLSKCTNLQHLIIHSLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLFRKNRRISFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXJ3</accession>
    <name>L7JXJ3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXJ3"/>
    <dbReference type="STRING" id="72359.L7JXJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1294"/>
    <dbReference type="HOGENOM" id="CLU_1318216_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXJ3"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl-tRNA synthetase catalytic core" evidence="7">
        <location>
            <begin position="142"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="23798" checksum="B8393A7D89BD77FC" modified="2013-03-06" version="1" fragment="single">VIKKFNNKVFSYTPCLSTPKMEHESFDIEDIKNDLIEYLVDKTSLTRDMALLATEVSKSFDKSDFTIQLAKVLHSKNNNMVNIDAEIDLQTDDFLTEVSKSKLCYNVKINKAKYCERIYNAIMSSDVYDAENVAHKAFYYGSKDVGKGNTIAIDFSSPNIAKKFHAGHLRTTILGNFLSNLYKYLNFQSCTDKSPGRLGETVWPSRCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXL4</accession>
    <name>L7JXL4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0975"/>
    <dbReference type="HOGENOM" id="CLU_2544217_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXL4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="83" mass="10010" checksum="E022D4D16E36DB16" modified="2013-03-06" version="1">MHHPMAMDMYLSVNLRIRAGVIKWFDMIAMWVRKENAICITWFENREIVILWDKHMHHRMAIIIVGRVLISFIHKLVNLIVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXU8</accession>
    <name>L7JXU8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0733"/>
    <dbReference type="HOGENOM" id="CLU_2924353_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXU8"/>
    <dbReference type="OrthoDB" id="420528at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="7212" checksum="FDF5D2C3F4C7C3D0" modified="2013-03-06" version="1">MRQISSEAYDRVSHEGLLAKLKLYGFHGKLLRLLTGMCRRPVCVCRDWRHSFSAVHVRHWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXX3</accession>
    <name>L7JXX3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subunit of the major N alpha-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.1.88" evidence="1"/>
    <dbReference type="EMBL" id="JH993856">
        <property type="protein sequence ID" value="ELQ76313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0715"/>
    <dbReference type="HOGENOM" id="CLU_2339355_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXX3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="98" mass="11617" checksum="EACCE4C52B8C9EC7" modified="2013-03-06" version="1" fragment="single">VHFHKFFIQSTFYFTARSFTPDTLSMKIRLLKGRDIPKVQRLNHLTLPENYTLEFLSIHYLLNPSTNYVAVQNDMLIGIPTSRQKRHDHKSERRQSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY01</accession>
    <name>L7JY01_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993938">
        <property type="protein sequence ID" value="ELQ75627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1416"/>
    <dbReference type="HOGENOM" id="CLU_1036507_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY01"/>
    <dbReference type="OrthoDB" id="2400393at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="269" mass="32070" checksum="7E82739434AC660B" modified="2013-03-06" version="1" fragment="single">VVKDLSKPVLHKGHILYLDNWYCSLNLFVTLLNSKTNVIGTVRAKRKNMPKDFLRTKFKTGEYEMRSCNGLLAVKWKDKRDVFILSTKHTTVAITQQITKQHNPTWKLKCVIEYNKEVIGVDLQDQMLACFPLMRKCMKGYRKIFFYLFDMALFKSFILHNKINNEKRQGYAEYKLKITELSLENSSLPHYNRERELSNGELPLRLQAQQWSHFRKHIDPTSLNQHPKRRCVVCTKHKQRRETTWECKKCKIVLHVPTCFERYHTVKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY12</accession>
    <name>L7JY12_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1408"/>
    <dbReference type="HOGENOM" id="CLU_3056294_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY12"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6333" checksum="AA143996778C11AE" modified="2013-03-06" version="1" fragment="single">VIVPFLVVLSIVTYFDGRIIIEESFIFFAVSLFYRVGDFNSSIFRRNVFVHDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY28</accession>
    <name>L7JY28_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0686"/>
    <dbReference type="HOGENOM" id="CLU_1355569_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY28"/>
    <dbReference type="OMA" id="MTIGLYV"/>
    <dbReference type="OrthoDB" id="2190291at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031539">
        <property type="entry name" value="DUF5090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17009">
        <property type="entry name" value="DUF5090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="202" mass="22789" checksum="2DCCEE3B4E222C80" modified="2013-03-06" version="1">MAEANTEKVKEKAAEVKDTVKEKSDKAEMKVKESVKKAEKGAVGQHIPTSLDNLTFKDIIKCTLFLNAIMTIGLYVIVSATRVNIDSKWREIFLTAAKYMILIFGVGGIVVDAIFFYGHLFSLFKVFLGLKAIKLLGVLIFSFSQKLGAWYIIAMSFVYLCSCVFIDICFVYYLAIFQERLESGDYDENGMPKKKQEGEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYA6</accession>
    <name>L7JYA6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1379</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYA6"/>
    <dbReference type="FunCoup" id="L7JYA6">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1379"/>
    <dbReference type="HOGENOM" id="CLU_019532_2_0_1"/>
    <dbReference type="InParanoid" id="L7JYA6"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="453" mass="50819" checksum="1FD736F0A6056170" modified="2013-03-06" version="1">MSLIDDYLSFLNRCLTPYHVISESIKILKDHGYKKISINDLNTITPGKYYIIAFTTVIIPIIVPNNPAGVRMVATHNDSPVLKLKPNFSDTVENMSVVRLCTYGGGLWHTWFDRSLSVGGLVVLRDGRQVIVDRLFDVVVPSLPPHLNNSKVYNNGFLYDKERVLNGLVMVGTKLEDRVFRGRCGTEMDDKREFNEDARDKSHDSGVAECVINDKSHNSGIAECVISDDETTCQDGTEENAVYFKLEDVVSHNLSLYDLARAELLNEQLIMSARQDNLLSTFLGLKALNAEGQCIKVLAVFDFEETGSMQVNGARCTFLKDVYNRLQNKDPHNSMIISLDVTHAYNFNYDECYEKKHRVKFGGGVVVKHGPAYATDVHSSAFVKRLAEFKCQDYSLRNDIRGGGTIGTMLSTLLGVRCVDLGTPVMAMHSIREATTCKDVMDTFKLLYDFYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYB5</accession>
    <name>L7JYB5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYB5"/>
    <dbReference type="STRING" id="72359.L7JYB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0611"/>
    <dbReference type="HOGENOM" id="CLU_145512_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYB5"/>
    <dbReference type="OMA" id="EYFFKMN"/>
    <dbReference type="OrthoDB" id="2190169at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="19947" checksum="56F9B5F3322CC9C1" modified="2013-03-06" version="1">MRSLKTARRFDSAGERTRPEGRESKHDAIARLKLKKDRTNKIKELKEEIHFKTGNEYFFKMNSLRQENDKLVRISKFDLAESKRQVIGLNFEIIRMEKKLQKTIPVFKPAKIVFNDGLEGVKVQCKQGLRPDKEKLTMYNDYLDRLYKTKRQIEKQIENAMKQKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYC3</accession>
    <name>L7JYC3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993932">
        <property type="protein sequence ID" value="ELQ75727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1313"/>
    <dbReference type="HOGENOM" id="CLU_636475_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYC3"/>
    <dbReference type="OMA" id="HNCINNP"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="490" mass="53618" checksum="EB067902DB76CF26" modified="2013-03-06" version="1" fragment="single">MPTTPSPAIQSAHAYIKSKYVLKSDAPNVIVLGGDGTFLSACGMMLSDGMVLGEIERMCGWLFGDCCVGRDGNGGVVCHGVNTTDINDHCINNSGLDEGSDNNCMNRVRGSDTNCINNNCTNRPNPNNNLNHNCINNPNDCINNNCTNRPNPNNNLNHNCINNPKTQTRTTAKTKTIYTPNDQNILTNPTNQPLTFYVFNYGHAGYLCLLDKEDLKKEFNDFKFVMQRLSRVVGKGYFVNELMVGRAYPGRLNTFEVHVYDCRCSDECNCSNCCSSNCNCCNCDSNCCDECIRCRCCDECSNKCSISPTGGTTSDTNPTTNTIANTSTNTNPKTNTIANTTLTINTNPTLTTISNSKTNPSTNTNPTNTTLTTNTNTFKFTIKCDSILISTQTGSSAYNRSAKGPIALMQCHIINFINPAHSTNALVVDIRRTIRVRVLTHNGMGVIDGVRWFGGDEFVVRGGAVVRMAYCESGRVGDGWMVERLYGRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYD2</accession>
    <name>L7JYD2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993930">
        <property type="protein sequence ID" value="ELQ75737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1306"/>
    <dbReference type="HOGENOM" id="CLU_2924357_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYD2"/>
    <dbReference type="OrthoDB" id="10652555at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="7366" checksum="0BD79C54BAEA7F35" modified="2013-03-06" version="1">MMKPKEHVHKELSTGNEHMKRMCESVRRESSTEITSECVGRLSIPVKRSRRFFYRRRGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYG8</accession>
    <name>L7JYG8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0667"/>
    <dbReference type="HOGENOM" id="CLU_043367_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYG8"/>
    <dbReference type="OMA" id="KPNINDW"/>
    <dbReference type="OrthoDB" id="10591258at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="261" mass="31113" checksum="1407A44C681239A2" modified="2013-03-06" version="1" fragment="single">VFGKIHHLFLGCIRLFFETRIASKCLLFPEFMTLNKFYSIFECYPQKITLFSRLSLIYVVDRFEVLFSSCIHLRQEAENFKNAHIHSKAIFNRHFFIRQVLFSQLLCIFHVQSNFIAKYMFIAEMEYNYIDSKGDNVTNTTFDMLENHYELLFFMSHNLLHIIKFSPKPNINDWDLITTLECLNDKTIVARIFRDHFGHIKEYYKESVKDLYTYVENHQTVGDLPDMNDILRRVEELDGNMEKMMLGLSGIYKMIHEGFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYU5</accession>
    <name>L7JYU5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">26S proteasome regulatory complex, ATPase RPT4</fullName>
            <ecNumber evidence="7">3.4.25.1</ecNumber>
            <ecNumber evidence="7">3.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="7"/>
    <dbReference type="EC" id="3.6.1.3" evidence="7"/>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYU5"/>
    <dbReference type="FunCoup" id="L7JYU5">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0840"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_2_1"/>
    <dbReference type="InParanoid" id="L7JYU5"/>
    <dbReference type="OMA" id="DHEPCVI"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="324" mass="36250" checksum="35602A84B5373CA9" modified="2013-03-06" version="1">MKKFIVKTSQGPRYVVGARKSIDRNLLIGGTRVALDITTLTIMKVLPREIDPSIFAMTEENPGNVDFGKIGGLTEQITQLKEIITLPLDTPEIFERVGISEPKGVLLYGPPGTGKTLLARAIAATMDVSFLKVVASSLIEKYIGESSRMIREMFQYARERTPCIIFIDEIDAIGGKRSTESSSSDREVQRTLMELLNQLDGFKSLDKVKVIMATNRPDILDPALLRPGRLDRKIEIPLPNDTGRKEILKIYIREMTCSERIDLDMLVKLSVGFNGADLRHCCTEAGMNAIRDERDAVCQEDFVKAIRKIAGTKKLETKMDYKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYV7</accession>
    <name>L7JYV7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0533"/>
    <dbReference type="HOGENOM" id="CLU_2741834_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYV7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8404" checksum="0AF94108DE3B2678" modified="2013-03-06" version="1">MIYTASHTFVAQISEASERELHLYDHDNMRVINEYLTMFLSRNSWDELFGLAEKSCPIYPTIHRLKLAHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYW1</accession>
    <name>L7JYW1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP-binding protein CRFG/NOG1 (ODN superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYW1"/>
    <dbReference type="FunCoup" id="L7JYW1">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0822"/>
    <dbReference type="HOGENOM" id="CLU_011784_5_1_1"/>
    <dbReference type="InParanoid" id="L7JYW1"/>
    <dbReference type="OMA" id="ILEHDEW"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="191"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="552" mass="64445" checksum="33E8BFF9C2A141A8" modified="2013-03-06" version="1">MVHNSFVDAFLVYCKFFNKIRLPIRMAFNFKAIKRIPLSLIDVVLSKTQRKTPTVIRKKHPLPKIRSFYTRKVKFTGAEYVAQLETIINSFPHVEDIHPFYNDLINVLYDKSHFKMALGHLNSTKKNIEGITNEYVRLIKYGTSLYGCKQLKRAGLGKMTSLVKRLKPTLEYLEEVRQHMSRLPQIDPECRTVLLCGLPNTGKSSFMNSVSKADVDVQPYAFTTRSLFVGHFEYNYLSWQVVDTPGVLDHALEEMNTIEMQSVTALAHLNSIVLFFLDISEQCGYSIDQQINLYKSLAPLIDRRMLIVLSKCDLKATVEEKNTVVEQIGLDDLSDDVRCFINDKQYALLSVFDPESVEKVKQMACDLHLEKSLESKLQKNLEPILNRINVHEPASHRPKEECMLRNGEEKIITEKELAKDNLDYYFDENKNYLVNEEEKYDVMPEIYNGRNVIDFVDPDVMRKVENLDRNFPIRDYDVFDNTIKREIDKRIKVKQEYSRSKLRASLPDRFKNNPRKKLSTCKEAGPKTRGPKQFVERQKPMEYNRKPKHLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ40</accession>
    <name>L7JZ40_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0310"/>
    <dbReference type="HOGENOM" id="CLU_578948_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ40"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="472" mass="53674" checksum="B85C196AD3687DA0" modified="2013-03-06" version="1">MDRNRKKIMEELIQKLEEKNRRKEQDECKTPEANEANTREHDETKNKTGVDEPDQQARVDNDVLYINQELLNNRLNRENKQPDTLKNAIKCIQCQFEVNGGEINFVFYCPQCNEYWLILNEIMGIEGNESSINLSRLGDNVEDESKVGVLQKILADLLPSISAEDVKDETRYETGTREESRASFDREQLNFAISDVIKMLQSKRRESGDLQTARDSPTRQTGFFSIGLQDGTPRLVEKETKKPEIDRKDELKQESSSDDALKKVLKRKAEEMNAVSMDQEDKSVQQTSEQELPLEEEQTSSTKGKNKMNFYTPISISDTYLVAQSDGTVISERMRGIAGKDTLMESPEESLMKKESQGSIDQQDTVRRLSKGVSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ73</accession>
    <name>L7JZ73_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0430"/>
    <dbReference type="HOGENOM" id="CLU_3126083_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ73"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="5933" checksum="E6E011B8D409A5A1" modified="2013-03-06" version="1">MTKGEAEFIDELIKKIKMVVEKSDDNAKRKYWGVNSTQFLKKYGHIEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ92</accession>
    <name>L7JZ92_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="JH993823">
        <property type="protein sequence ID" value="ELQ76734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ92"/>
    <dbReference type="STRING" id="72359.L7JZ92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0272"/>
    <dbReference type="HOGENOM" id="CLU_375810_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ92"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF32">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="739" mass="83455" checksum="A1C9F91587520295" modified="2013-03-06" version="1" fragment="single">VTEFNIQSLRKCVLNGPKRYPGANFIINKENKRISTWYNKRILIGDVVERHLIDNDRVLFNRQPSLHRLSILSHFAKIVPNKTFCFNVSVCAPYNADFDGDEMNVHVPQTLFARAECSLMRIKENLRSPKDNQLIIMPNQDFITSVYLIGNEYFDEMSFSTYLFEVCHASKDYEMARKIRPSILRPTRIYTGQQLLGTIFKKHGPFKTLITKKMLKQYLSEMSNEEIVIAENSIARVSARFIGERGFSIGVDDLEYKNEENKMIGIKTLIREYVEEMDSDNIAELSSVRDKISKTIKLIPDNSALIMAESGSKGSKINITQMVAMVGQQVINGQRVPLSYSGRSLPHYFDKEVNITGLGRTAENEPGNSSRLSTTCSNTSVQMAGICGQTSDQKNENVGDTMNNRFISSCAMDDSLPCTDNLKHVPEAESKAKKIGKKDSDEEKMLFRGFIKNSFFTGLNAFEFFFHAISGREGLVDTAVKTAETGYMQRRLIKALEDLKLCFDGSVRGTDCVIQFPDSNSSYFRKGFQPGDAVGAIAAQSIGEPGTQMTLKTFHFAGVGSMNITLGVPRLKEIINASACSTPVIRISGRRKTLSDMRRLNDLIQPLRIENVIDYVDINISENIYVDFRTKAKYRSLNKTMQERLEKRYKNETFIHNDGVRMYLDVNQDSIYTLNDMKLQVGKVFLRGIGTITGTVFNNVERESIDGAGNKSGVNTKSSPGDEKCKRTRKDSLRYVMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZA0</accession>
    <name>L7JZA0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA helicase PIF1/RRM3</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZA0"/>
    <dbReference type="STRING" id="72359.L7JZA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0217"/>
    <dbReference type="HOGENOM" id="CLU_184018_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZA0"/>
    <dbReference type="OrthoDB" id="6369095at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="75" mass="8370" checksum="6CD4BCEF03F337B6" modified="2013-03-06" version="1">MPPHKLVLKRGTLIMLLPNLDLANDLLNGTRLIVDELHNNFIIATIVTGSKKGNRVIIPKINMALSETQLLFILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZF5</accession>
    <name>L7JZF5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZF5"/>
    <dbReference type="STRING" id="72359.L7JZF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0198"/>
    <dbReference type="HOGENOM" id="CLU_081072_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZF5"/>
    <dbReference type="OMA" id="TENMKAS"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="299" mass="35170" checksum="E2F5F0696DE97DC1" modified="2013-03-06" version="1">MAIQEKLRSFMDEIRNLKIRLELDKHKIEELNVQKAFLDKERENKKRKISKIKTELVKYTTEQMSYVTELPEDIESLEKQIASELAKITFLNADKKVLKDYKEKEKLLNDFHLKELEMENKRKVSNQDINNLREDLINSLNEKVAVVNDNFANFFQKLSFDGKVELETENMKASKWKLNILVRFRKEEQMQQLCSYIQSGGERSVSTIIFLLSLLEATPAPFRLVDEINQGMDSYNERIVHNLLVDLIRNKNSPQFFIVTPKLVDNLNFNDSMRVFIIYAGEFGRIGNKFEECKTALMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZI3</accession>
    <name>L7JZI3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0168"/>
    <dbReference type="HOGENOM" id="CLU_963737_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZI3"/>
    <dbReference type="OMA" id="MIKEMQV"/>
    <dbReference type="OrthoDB" id="10460689at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="289" mass="33834" checksum="CBB313B9A1E137E7" modified="2013-03-06" version="1">MSTKIYVLDAEVRLNQCTNKCAVLFSHYKKRRTNYKNINHQKIMLILLITLSKAMPSDETLADLSGLKTNNEKLSEFIKLISQVTIADTKEIKELDLNDKILRDYNACMNSSKDYEEKLNSLRKSLDDNKSKNGAKPVLKEIDFFNYDTEAFFKKLVGLFSFFSERPDLTDKFSELFTDSLRVLRHNSSPVEGDTKTTTNTILRFFGFGKNERIETDEDHKQFRTELRRFVDHYKQILDHLSKILYSDGMIKEMQVENKDLNKISQDFMKELETFKSHKQQHLQTGNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZJ5</accession>
    <name>L7JZJ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0503"/>
    <dbReference type="HOGENOM" id="CLU_2764971_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZJ5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="70" mass="8180" checksum="1C72B0547362E645" modified="2013-03-06" version="1" fragment="single">VRSSNLQTTAFMINSLFSYVFLHFYRVRYPYFCAYLLGEFVNHLRYGLKYAAKAGIYSAFVSSLTDKLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZL0</accession>
    <name>L7JZL0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA polymerase epsilon, catalytic subunit A</fullName>
            <ecNumber evidence="7">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="7"/>
    <dbReference type="EMBL" id="JH993809">
        <property type="protein sequence ID" value="ELQ76874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZL0"/>
    <dbReference type="STRING" id="72359.L7JZL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0133"/>
    <dbReference type="HOGENOM" id="CLU_368497_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZL0"/>
    <dbReference type="OMA" id="WYGTEET"/>
    <dbReference type="OrthoDB" id="10354492at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase-epsilon zinc finger" evidence="6">
        <location>
            <begin position="729"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="782" mass="91886" checksum="ACD01E052A03B6DC" modified="2013-03-06" version="1">MCTNACPARLSSTYFLFIHLDPMSFSIVHGLKDEWLSKLKTKTDRKVCVYHKKECNKSTVYYLLGDKLVIDEYKDEEYVLITEKSDFMDKKRFTFFLSDENVSRNFNEIPKRYANHLSIKQYYEKPNALNYTICTCNYTPLVSFVHNKRTFYAFMRNNSFYMCINEKKIKGALFVMCINDQKSKSFMNRRNALVILLSIKHVMVHDVHKAAFSFLENVTHDVPNGLLTNAYNTLIMLNEQVQARLRICAFAKIPLMNYSVDSALNNIYARMMHANKMVKNERTEFEWYGTEETMMSGWYENVVEIEIVDAMIIGVKRYGKGIGARLHGFIAKNDVENRCADDEDKYGARHQNENVGGCEVTARKREDGHKNECNSIMDGNFAFNDDITYKKDVDRPVIFDETAPANDQYEAPLDLVTENGSNAIKEEKNNEQDAGEHVYYEKENFFNNANEKIKGKERKDDKSEDVLRNKYDDVLQTDDTNFMEMTVFKKFLKYVANDKVLFNELPRWLIRTRLISKRLKNLIRQLSNDYVLGCIKMINKHNLVLASSKNMIFVHIKDENELKNVMEKNWRILRRFEKLIYLDHDNYFYLKHGDGTFRERIGCNTLYKIPLSFLETAFRGDTISVSYFYGLTKKNVDVLKVHEIYALKDPRIGEIRSNIYKLLGLNEFKIKDEQEIRTNMICISCRNESVLVITDRINKCRRCFNKFDVESVENALIDYIYEKIKVKEYVCESCEVYRDRRLVMECTCGGKYKKVIMDYSFVKDVVTTKRMADYIDDIITKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZT7</accession>
    <name>L7JZT7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0052"/>
    <dbReference type="HOGENOM" id="CLU_141794_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZT7"/>
    <dbReference type="OMA" id="RLEFAWH"/>
    <dbReference type="OrthoDB" id="2191262at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="147" mass="17244" checksum="37D03BE8020DE1CE" modified="2013-03-06" version="1">MIGERNLMNEEKQMRYVYVFCVLLILELTFFGLAIYFTNDVQFKSVYLLHGSASLLGNFFLVEGIIIKNFVQISLYPIIYLFTFANTFLGSSRETGLYFVFKMAQVGVYVVRGFILYHVFYRLRLEFAWHSFKRLGTSTQVIGKFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZU0</accession>
    <name>L7JZU0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNARE protein SED5/Syntaxin 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZU0"/>
    <dbReference type="STRING" id="72359.L7JZU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0179"/>
    <dbReference type="HOGENOM" id="CLU_159694_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZU0"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="96" mass="11172" checksum="2E0D64AA46CC78BF" modified="2013-03-06" version="1">MQETTSTIKRQNYAMLNTQITEIGQLMSDISMHINIQGENLKRIDEVIERVDDNLFGGFREIEKVWNSVKGRRKSIGVFVAVWIVLILLYVLFRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7K049</accession>
    <name>L7K049_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cdc4, F-box and WD-40 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K049"/>
    <dbReference type="STRING" id="72359.L7K049"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0583"/>
    <dbReference type="HOGENOM" id="CLU_000288_103_6_1"/>
    <dbReference type="InParanoid" id="L7K049"/>
    <dbReference type="OMA" id="PANGHCQ"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="226"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="426" mass="48670" checksum="D768AA5AC9FBE6AB" modified="2013-03-06" version="1">MPPQNAPQCMTNTKKRIKIANSLHKLPNELLSKVLIPLSLPNIKNLSKLRGLQHKITSNYVLWHSKCMLSNVSTRRVERSDGYFAAYKQYCRIRRCWMNGHMESRTVFSTNQPDITHVQCNDRYIVVSSDDQSIKIFDVDGNLRRNLVGHFGGVWTFQWHKDVIVSGSTDKSIRVWDFVTGWPLRHLKGHRSTVRCLRVYKDYIVSGARDSTVKVWNMDGVLLHTLRGHGESVRCIDVCHTMLVSGSYDGTVILWDYPKGTMVRRLKSHLLRVYAVLIGRNHIISGGQDTFIHVSDMKGQFVTTLHAHRSIVAWLELTSDPVQRIDHLLVSAGADGHICIWDLRTGTLRSKIVESMPITTIALKNECLFVGVHSRVKVYDLRDAQFKRTLIDNLSSVYKVYCTESRVVVGCKRNTCAEIAVFTYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7K052</accession>
    <name>L7K052_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase, LTR Retrotransposon</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K052"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0588"/>
    <dbReference type="HOGENOM" id="CLU_2499466_0_0_1"/>
    <dbReference type="InParanoid" id="L7K052"/>
    <dbReference type="OrthoDB" id="781466at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="86" mass="10451" checksum="C0752E944E1E0342" modified="2013-03-06" version="1">MRLEPIYYELKERYYWLSMKRHITEIIKRYETCQRNNRKHTGGNEMVATTRPLEKVTIDIAKIKDKTIMIAIDYFSRRIWVRGVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K070</accession>
    <name>L7K070_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993821">
        <property type="protein sequence ID" value="ELQ76741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0267"/>
    <dbReference type="HOGENOM" id="CLU_811792_0_0_1"/>
    <dbReference type="InParanoid" id="L7K070"/>
    <dbReference type="OMA" id="LYCTMES"/>
    <dbReference type="OrthoDB" id="10400837at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="342" mass="38843" checksum="B101E8C388CB1901" modified="2013-03-06" version="1">MKEHIISLILSISLITSFICLNKGVKSSYRTFKSVVIPMCSFMSMIINAILIRKKSDHNIVYTLAISLIASLCDFIILYCTMESMKVHSIAFILLAFIGFCVSLFLLDRHVSLITLTINSLMIVVLFMFEVFEYNGVQLHSTDLEIAFLKPYMSMLFIIVLVYGFRMVLVHKFSGLIEERPFVPLCHNIFLMIFAVLEASFDSFADLKVFYSEISHCWVIVLGSLFLLPTIFLSSQNTKWVQKETFLFSLAVLITIVTCFYVVSSFDYVFGKNRLEMLGSWCYASLLLVFTITIFFILFYKKRLLNRAAAVSNVEIVGADVASPTNEPPPAGVPPEEDLLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7K078</accession>
    <name>L7K078_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K078"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0525"/>
    <dbReference type="HOGENOM" id="CLU_1349805_0_0_1"/>
    <dbReference type="InParanoid" id="L7K078"/>
    <dbReference type="OMA" id="FVTLYRK"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="234" mass="27631" checksum="2EBA13D8462793D5" modified="2013-03-06" version="1" fragment="single">VPYISYHLTCQLFPSAPSQKYFSLTNRPVLESKMLKYNGIVEITGKKGSGRTNIVLKESQRKGTLFISVKPLPINRYTNLLAKKYGNKITEIDDHLNNTFILIINKLERLEAFILYKLNDLVKKHGISLIVLYEIDFLLLDDYVEMDSIFCVMNKLHEIKYNNRLDVVFVTLYRKVFSHNYNIRLSMEYFINERYQVSRRNDARKIVHVNYSNNDVFNVLITDDDVIYVRKQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0A9</accession>
    <name>L7K0A9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0A9"/>
    <dbReference type="FunCoup" id="L7K0A9">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0A9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0138"/>
    <dbReference type="HOGENOM" id="CLU_065898_0_1_1"/>
    <dbReference type="InParanoid" id="L7K0A9"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="8">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="244" mass="26543" checksum="2B7C4DA09A77ED4F" modified="2013-03-06" version="1">MEGTKEQRARPRRTRENINPLDAWQPKTHLGTLVKSSRITLSDIFTYTLPIKEPEIVDFFLKDTLKEEVLCVNSVQKQTKAGQRTRIKALVCVGDGKCFVGIGAKTSRDAATAIRGAVQRAKCALMYVKLGYWSSSVGKVHTVPVTARGKAGSVRIKLIPAPKGTGLVAGGVPRTILRMAGVKDIYSKSVGQTCNTENFAKATVDALVRASNFYSPDLWNSKVEGVNPLLRGDDGAAGDRRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0H3</accession>
    <name>L7K0H3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993824">
        <property type="protein sequence ID" value="ELQ76732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0H3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0275"/>
    <dbReference type="HOGENOM" id="CLU_1620239_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0H3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="164" mass="18797" checksum="AE2EA9604F2FD7E9" modified="2013-03-06" version="1">MTLFPSSGTFELLRSGDIIEKVTLINVRFYDSMITVPNNIQEITLKNIVLGRIGFWVFPEDIKKITLEKFSDHVQLNGFTQDEPLVGHFNDGTFCSYKSNENEQIELVFSNVYLAHGLYFHSNISRIVMSCVSIDPEFSLKFNEYITEVSLDDCTCNLCFKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0L8</accession>
    <name>L7K0L8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_0055</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0L8"/>
    <dbReference type="STRING" id="72359.L7K0L8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0055"/>
    <dbReference type="HOGENOM" id="CLU_281071_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0L8"/>
    <dbReference type="OMA" id="DEPHYSI"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="46"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="1085"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="658"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="807"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1041"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ76957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1163" mass="132995" checksum="25D49F8FC9DD8A60" modified="2013-03-06" version="1">MTQEERQHTKIDLNYLLDCAELVGYSRNVPSEIAQLCRSRINLHNFALIRGIAKGGYGSVYLVQSNQSQQYYALKVIKKQVVIDMPHLALFENEKAALKSARDAQYLVFMHCSFQNERSIFFLMDFYPCELLERVPVHDEQELRFYAAGVLLAIEELHKLGYVHRDIKPENIFLDSAGYVKLADFGSCCRIKDAKGCINENEAMRSTCSRKFTGGSARSSGSTGSATRSEIMVGTPDYIAPECFTNEQGVEVDMWAYGVVLYELKKDETPFYAATLTETQSNIREIKYEKCAGVFGDLIDRLLQYKHERINVQQCKEHPFFEGVSFGEYAGGLRPPFVPEVSTEKEAVHLEDEEIEHTCDFVGFGYDPSFDGFEVCMGCRTVAGMVDEHHGTMECGEETHFKNDVVDRRTCPKAVVDRMACITNDEIDRNKRIENAASNHNKYVENAVHRKINHELYDKSKESHSAQANTTDSACNQNMHGMPTKRLTCTSCGKTEEVVEKEPFTGVYMQSKNSTGTTNEDVPEQAIRTGTVDKYEHVNNALAYDALVKRCTALVNENNTLKQRTRMIDTVLNTLRSVDLNAYHEKVRNMMEKFRTLDAFKTKYKTLISTNQRLVKYKEECEDLKIRNGVLTNIVKREQLERMSRNSCECCSNGCNVGEEKDSHRDSGCNSKDSSGDRDGDSNRDNKISNKDNKISNKDSSNTTPTTDTTNTTNTINPTNANTINPINANTINPINANAINPTNANTINSSRIFSFNTGCKQGIEVDSVSKRKAANERLHRARDEGVGDEHSLEKKLPKCSQLKDNVLIKTERMIELESELERMQRNNNELKGRIARMSDDKARYKRRIALMKDKMVDYNYYVNTVVNNVKITLHEIDIVSLYRRMNRDIRTLSKMLKIREQEKKEVELMNTTEVTIRKKLEKEILRYKAEIKRLRAKGEINIVFKVRVEGEKALLRIEKNQLYLLDIVENLCNCVCANLSKAEKLRYKRKNVVKLVFIEEGTPSVVHTRSRSQLLEDLRKEKRLYASIEKLSTMHTGKVLEKARTQLEGSLRKIKYLEAEIENADDSDAQHESTSREDVLFYDGHVFVRKKGLSGYCNFCDEPHYSISLSCEQCGITVHRQCYMLAMSCDMCKSVKKGRSFMVEMKNFEEVERLVKILKKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0M2</accession>
    <name>L7K0M2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0M2"/>
    <dbReference type="STRING" id="72359.L7K0M2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0004"/>
    <dbReference type="HOGENOM" id="CLU_479109_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0M2"/>
    <dbReference type="OMA" id="HNECLPR"/>
    <dbReference type="OrthoDB" id="2191713at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="520" mass="61278" checksum="C4F625A092D80DB5" modified="2013-03-06" version="1">MTLKENYWRDFKFTQKLGQGTHASVYKMMNVHTGQHFALKEINLCYQEDVHNECLPRHITHKNIMKYTKLFVSERPEQLKDVIASDNDEQDCVLDMQKLRNRVRAMNEHSIFSDGVGSLKTQGCERRFYYMVCDYCEFTLDEFIAKRNELFFYGRDLKGMLDELSVDEVDDKTMEGNENDVLLFKRTKRDLSLRCAGKQSWCRHFTSESNGRFYRTSTSRQSVLNDHDDRTGHHSIVNNHNDRTGHHSIANGHNEIKTSNHSIERDRNDIKPGNHSILNNHDDIKPGHHSIVNDCNDRTDHQSSLNSKFFCSTQQFTKKPKKQQNVIYFDTGDLFTQNYKNRCNKFLKCTANVLICQNRYFYLYNSSIINYQNKRCINRHFIAMLFKDIVRGILYLHTNNIFHCDIKSNNILLKHETVLVPKISDFGLRRSVKCRKCHYKDVYDCGVLYFEMLCPVKTVMEMDVLRTRLKETGELPEWFVSAYGEETDIIRRCMSGRRAGAMDARHLFKRMIELCKRMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0M6</accession>
    <name>L7K0M6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0M6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0024"/>
    <dbReference type="HOGENOM" id="CLU_1807578_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0M6"/>
    <dbReference type="OMA" id="ECEDNCI"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="16726" checksum="DE919C2C1FA10945" modified="2013-03-06" version="1">MKTKFSSRNLKILTIDANVFLFLDTTDLACSDIKVLKIRFVWLVEGKNKMRIKKIELQELFIECEDNCIDPEWTLIKKIELVTFIDLLAKRINFSTLKYFAFISNKELVAVDPNTLMIVSRHQGTKTHHPSQTITYKDNPNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQW6</accession>
    <name>L7JQW6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative phosphate acyltransferase</fullName>
            <ecNumber evidence="16">2.3.1.15</ecNumber>
            <ecNumber evidence="16">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_3269</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.15" evidence="16"/>
    <dbReference type="EC" id="2.3.1.51" evidence="16"/>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQW6"/>
    <dbReference type="STRING" id="72359.L7JQW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3269"/>
    <dbReference type="HOGENOM" id="CLU_031891_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQW6"/>
    <dbReference type="OMA" id="NQDFAQR"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="118"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ73829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="472" mass="54911" checksum="D9DB4C7313460C9D" modified="2013-03-06" version="1">MRRSFLNDAADLVSLGTRSINADSFTKCFSPISALEMHHSGVLYIFSILIRYLLLFPLRFTFFIAGTLVFAFFFLVGVIFKSDRIIAFSFWLYCNVFCMSFGARIRNHGNKKWLNVPHVYVANHTSFLDFIVLSSHKFCHASLAENHGGLFGFFFKNLLLRNGSLYFKRCEKNDKSIVKERIKQHIQSMKTPMLIFPEGTCVNNKYTVMFQKSVFEIDATICPVAIKYKRTLFDPYWNRRRHTFTEHLLYLMSRWCIDVDVYWMDPVNRGKKESVFDFMNRVKTAISAKGGLVSLKWNGYMKNRIIVKDIEILRAAFRQTYLDVIGERAHENKQVVSEDVICKNFSMNDLDNVGEKTNGQIVKSTKNGKHNVIYFRQDKSAPSSSAGVHSEQNTTNRKQGGRSARRKELYVCENPELIYFDTTNYDTFIKTVLNRYSLIKYQRCDVKCDFDNFLVKTMKVGCSCNNKKFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR08</accession>
    <name>L7JR08_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3249"/>
    <dbReference type="HOGENOM" id="CLU_1168324_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR08"/>
    <dbReference type="OMA" id="SSYKPPM"/>
    <dbReference type="OrthoDB" id="10534231at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="238" mass="27550" checksum="E1F5F2C2C01FB406" modified="2013-03-06" version="1" fragment="single">VLFPNTDVSPSTVKPRITIKTAHTNTNRVSLQSIKKNEMIKLMNILHLISTTTLFTFVLTFSNKKKNGKKEPKDELVKKDDVILQPSFGIFDNKNDKTNKNHKDDNIRDTFKDSDKIAPIFTKDKRDDKKESDDKDKEKEISNEIMTQSSYKPPMVTMLLNKNKKEDERKEQLAEYDQMRPIMNDALKNLYSAVSTMDKLANVLRDDMKKGEEKKMKSSAPEERIDYKIIEVTDNDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR92</accession>
    <name>L7JR92_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIID, subunit TAF7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR92"/>
    <dbReference type="STRING" id="72359.L7JR92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3155"/>
    <dbReference type="HOGENOM" id="CLU_069947_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR92"/>
    <dbReference type="OMA" id="ITPPMKY"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="193"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ73959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="261" mass="30625" checksum="0AFF20B18481959D" modified="2013-03-06" version="1" fragment="single">VVTFYPSMVEEHVILRIPDTLREQFDREIEELGHPDCEFDFTDSENITLRYKGTKYKASLIPLPCILEAQKTFDGNQFYKINDVANMLVVWPKNYTEVEINHYTKIYAASGITPPLKFVKYRRWRERAQSLSAVEEVEKKVKELLERDKLATSVRIQTINADNEEEDVSSLAAELEHNLLDEYLVDQKQFEEVAVESEMVRELKRQIAEIQEKIKEKKEFLKSATNIIVQRRFEEAIKNLSTELDEIRTKLNSQDTRCNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRA2</accession>
    <name>L7JRA2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRA2"/>
    <dbReference type="STRING" id="72359.L7JRA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3284"/>
    <dbReference type="HOGENOM" id="CLU_132184_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRA2"/>
    <dbReference type="OMA" id="DGSWMGV"/>
    <dbReference type="OrthoDB" id="2189688at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="19126" checksum="6C8F50F3E113164C" modified="2013-03-06" version="1">MRYKIYIDGDFTNVKNVFIDQTVRVKIKCSICDQEHPNRVVVSEESFNRVDDKEKTNLKITCSGCKSSMGISIRSPKGDRITIIRDNQPVRLQLSEKEFNSFYVSFLETKKCELIGEVDVDCSVLSGQKVLYEHITVEDGSWMGVDQKGLDSRIGDMVVRYEKVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRS3</accession>
    <name>L7JRS3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor of the Forkhead/HNF3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ74000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRS3"/>
    <dbReference type="STRING" id="72359.L7JRS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3093"/>
    <dbReference type="HOGENOM" id="CLU_1251509_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRS3"/>
    <dbReference type="OMA" id="SAPLWYS"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="221" mass="25859" checksum="91D5BD6668CFB702" modified="2013-03-06" version="1">MMSCSPDEENYKSSFLKRLLDFERKMNEEYANRTGNTYKYTPMDVLNRNNDDSEKMYVDPRIILDENDSNSAPLWYSNACNKPAYSYSQLITQALESNADKKLTLSQIYAFIKDKYAYYRHADPVWQNSIRHNLSLNKNFKKVQRPQNMPGKGGFWILDKTSDSEIDEPESCATSSECKVHKQQEQTDKFKFLHEGEPVEIKYFQTKDDSLFSGSIFLRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRY6</accession>
    <name>L7JRY6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2874"/>
    <dbReference type="HOGENOM" id="CLU_3056299_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRY6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6351" checksum="95DF19D164042974" modified="2013-03-06" version="1" fragment="single">VYMNVSFVLDMCTRQTTKFALRSELMVEDLFNQLLDIDTCKRKQTKVTRTNFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS02</accession>
    <name>L7JS02_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS02"/>
    <dbReference type="FunCoup" id="L7JS02">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2820"/>
    <dbReference type="HOGENOM" id="CLU_041220_2_0_1"/>
    <dbReference type="InParanoid" id="L7JS02"/>
    <dbReference type="OMA" id="ANYRTWC"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000081">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="266" mass="30694" checksum="CC45271B91237C10" modified="2013-03-06" version="1">MSIQYKKDLGQHILKNPGIIDRIIERANILETDTVLEIGSGTGNLTVKLLAKAKKVICYEKDERMAAELVKRVKSLNMYHKMKLFVGDCMKSDFPHFDLCVSNIPYQISSVLIFKLFSYNFRAAFLMLQHEFAMRLVARPGSPDYSRLSVSTQLFSKVEYMFKVSRKNFNPMPKVESAVVKIRKRLEQPDINVEEFANFLRICFKRKNKTLGGVFGDKSVVKTVGKEKREIGEILSTYGVKRANKLQVEDFLQVFLNFKLRKIVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS20</accession>
    <name>L7JS20_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS20"/>
    <dbReference type="FunCoup" id="L7JS20">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2802"/>
    <dbReference type="HOGENOM" id="CLU_066040_1_0_1"/>
    <dbReference type="InParanoid" id="L7JS20"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="274" mass="31318" checksum="3CA41CCCEA40C057" modified="2013-03-06" version="1" fragment="single">VRVTLYPLMLRLIGLGLDDLNDISLKALQIVKNADKVYMECYTSIINSTVEQMEHLYQRTIVLADRHLLENTDTLVDEGAQQDVVLLVPGTPLFATTHTDLLIRCTEKNVKYQVINNTSIYNVIGHIGLYSYSFGRVVSIPFFSDGFRPQSVFDRILENISNNLHTLCLLDIKIDKSYYDTNGSSTNRFMSANTAMHQLLEYERTVHSGVITERTKIFVICRFGCHDQSLYYDEIRNLLSTNFGKPLHSLIIPARMETIEEEHVNAFFNKGNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS36</accession>
    <name>L7JS36_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3236"/>
    <dbReference type="HOGENOM" id="CLU_3193998_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS36"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5299" checksum="2C187B4D70F6C6E4" modified="2013-03-06" version="1" fragment="single">VSFNCDIDGWIECYVRSCLFGLVIHSIMKEENLHVLNTTLQISNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSD2</accession>
    <name>L7JSD2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2691"/>
    <dbReference type="HOGENOM" id="CLU_2251926_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSD2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="104" mass="12062" checksum="D0CD48BD784EBD8D" modified="2013-03-06" version="1">MESAITTAVRCIQSTIAPGVSLKGDTFPEQMWFVYLHNLEIISKYESKVCDLETKNNRLMKSNKVLKDVVAHYMNNQKIDKGKKTFFGRLISFFRCYTLEENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSM1</accession>
    <name>L7JSM1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_2796</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSM1"/>
    <dbReference type="FunCoup" id="L7JSM1">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2796"/>
    <dbReference type="HOGENOM" id="CLU_000995_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSM1"/>
    <dbReference type="OMA" id="KFARYTH"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001141">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="349"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="573"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ74290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="791" mass="89444" checksum="9AF1BF0EC40FC20D" modified="2013-03-06" version="1">MAKRKYEEFTSDQSSVEDEVLSYSQSTMSDMQSDVPIDLPSAADIYLESSVPENYNDVEVPENEENEELPVNKEVMENESYKLKIKNLFAKFLSNYGGRKYIKLIKTMCAENGESLLVSYTDMESFDDLLVRVLVVCAEPAIEVFDDALRLVVLSLFPNYFMIRVQVHVRVIDVPVVEELRELRNENLGCLVRIRGIVTRRSGVFPRLFLAKFICTKCRCTFGPFLLENDASFRPQSCLECQSRGPFLVNEEETVYRDFQKMTVQEIPGTVPAGTLPRSKDVLVFHDLIDLAKPGDEIELTGIYKSGMLNDTIFTTHIIANAILRKESSCVLTREDEKEIKRLARNPRIVEILSDALAPEVCGHPNVKRACLLALFGGQPKGREKENDKASAAHRIRGDINVLIMGDPGTAKSQLLRSLERVAPRAVLATGHGVSSVGLTASVRKDSNNEWMLEGGALVLADNGIVLIDEFDKMQENDRSAIHEAMEQQSISVSKAGIVASLNARCAVVAAANPRKGRYNNALSLNANVNLSEPILSRFDILCVVRDVTDQVEDERIASFILKGIRDRSCSENASYENQNGMPSERSEHGPLSTRSEPISTQGTGAARAVIDDDLFKKYLIYAKRIHPQIKEIDKDKISKLYAELRKESDNSMPITARHIESIVRISEALARIKLNEYVCKEDIDTAIKITLDSFISAQKYSVVKTLRKKFAKYLNENDDFFVYLFILNEMFNDKIKSFRHVPNNVVVDKNEFEKRVRGFGIKFNYKFYKEDVFAREYNLTDSSIRREIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSM9</accession>
    <name>L7JSM9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994050">
        <property type="protein sequence ID" value="ELQ74300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2781"/>
    <dbReference type="HOGENOM" id="CLU_3108112_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSM9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="51" mass="5833" checksum="225AD117CFEB69B1" modified="2013-03-06" version="1">MNLEISKPQSLEENNENLGKNSLIYTISRLSLQNLFTMQAVGIWSIEDDPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSP3</accession>
    <name>L7JSP3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2758"/>
    <dbReference type="HOGENOM" id="CLU_2177192_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSP3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="12959" checksum="393A937DD4B9C9E0" modified="2013-03-06" version="1" fragment="single">VALMSGAKTNKSRKFNIPKIESDASHDIKPSSLQNKCNVVENVLDESQNFIKRPKKMLELLFVTWQDRESSNLKNKNGRKDYYTDNNVSFRFSELKERFIDFRGRYTSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JST0</accession>
    <name>L7JST0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHD Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JST0"/>
    <dbReference type="STRING" id="72359.L7JST0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2997"/>
    <dbReference type="HOGENOM" id="CLU_1816373_0_0_1"/>
    <dbReference type="InParanoid" id="L7JST0"/>
    <dbReference type="OMA" id="MINCICR"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="149" mass="17214" checksum="FE741D8D6E811952" modified="2013-03-06" version="1">MINCICRINHSDLDMLQCDKCNAWSHTVCCGFFSNNDKRIPQFYTCNICLDNDISRLALYRRALSVNYNEEILGVGWLGKRLGVKEGVARRIVKKLLNDGFIEIIALNTRQRKYVAVKNENVKKKVKKYFYIGKVKHSLPIKDISMAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT50</accession>
    <name>L7JT50_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase Rab6/YPT6/Ryh1, small G protein superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT50"/>
    <dbReference type="STRING" id="72359.L7JT50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2518"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="L7JT50"/>
    <dbReference type="OMA" id="NCFFRET"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001204">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="198" mass="23114" checksum="308EB3D834D898D5" modified="2013-03-06" version="1">MRSKYKIVFLGNQSVGKTTLISQFTNKEADENYHPTIGIDFTYLKVNLQGREVRLQLWDTAGQERFNSIIPNYTRGAYAAIIVFDLKHLNSFENIDHWIRDLVLINDPDRLTKIVIVGNKKELVDEKEREEVKIRAVEKAKEYNGKYIETCAMKYEDIRELVDHVNDLVIQDFAENDEEDKDDVVEIQAQKGRRCCPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTD1</accession>
    <name>L7JTD1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2440"/>
    <dbReference type="HOGENOM" id="CLU_314281_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTD1"/>
    <dbReference type="OMA" id="RVYCEMM"/>
    <dbReference type="OrthoDB" id="10383290at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="924" mass="107810" checksum="E9C4BF0CE4999947" modified="2013-03-06" version="1">MNQEDLKSLISEVFRFRAKIELDKKLENYTMVYPDTFYLLSSVPRGVDLIREQLEKRENIDILCLKEFLLDNQKGLPCISIHIKDDCVDNYKITFRNKTYFLSIKIDKVDATTDDISVDGHQSNKSTMNGKRTVKIIESAFKEIFEMETSRILKQQTKFYDFLQRTDDKAYANFFLGNYTEACGQFSKNEKRVYCEMMRNKRLSLDPDLFSYITGKDEENTINIDRLTLVFFIFLYTKITENYSHYAFLYHLVDFENEYINVVLSVEMARVMELLGSHKRKRLFLLYSAAKVLYDTGYFEKANNILRKHFPESVLYLESLINVESMNSTGKDMLQGILKQYHSNKNLNFELIDLLDGIPGIGLDVKLRYKLFKSYQNNTLPYNGVLANDEELIIQIYDDIEDAEIEYELVDSSEIENEGKLRIETNSTITKPVNYRVEKVNGCTNIYIQANASFLLHRISFNIPDKTVKFNCVIDKEVVLNGDAHFLKIVNQEKEVIFNAYQKAEFMLKVISNRTRMVTIRINERFKFDKLIEKGENAIKFDFQFEEGTHILIFTVRPTLYDYTLPHEETNDTYASAHRYELHAVVAKSLSLEINTESVLNCLEIKLKNFTERELSLKRMELLNNDYQMVGIGFARDRRERAEKIIEKISHELVLQGEDPTGTNLQGLSTTKNIPIDQFDSLVGADFVANEQSSVDMTKAASSDPIVRVESNSEKRLFLFFKRKMKSTEIRNYDKCLEQLVFNEEYVQQRGMDGAREAFIRNTFYLNGSTYSHKFANRILNFFASPIPYELPITFYFDGVTPFVRYGPFFNFSTGNFKNMFFKIRKNLLDWSNDKLVFMDRLNQLSDTPKAYVLNIKDQSYVLAVNPLENQLVFEIEVGQTKLGELILKPACMRLVRWQNDENVPEFEIKVKCLSGNISVVYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTN4</accession>
    <name>L7JTN4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-disulfide reductase</fullName>
            <ecNumber evidence="2">1.8.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.8.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JH994032">
        <property type="protein sequence ID" value="ELQ74655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTN4"/>
    <dbReference type="STRING" id="72359.L7JTN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2406"/>
    <dbReference type="HOGENOM" id="CLU_170543_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTN4"/>
    <dbReference type="OMA" id="MYVDEFE"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="13461" checksum="4F5649704FC2914F" modified="2013-03-06" version="1">MSKETSQEIQELPTITSLADLKKIAKSTKKPLILKFTAVFCNPCKIMSEELKKYKGRDIALLNIDVRESADLAKHFGVRAVPYCCLVDEECEVVRDRSGLMYVDEFERFVEGIGEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTR1</accession>
    <name>L7JTR1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2281"/>
    <dbReference type="HOGENOM" id="CLU_3108110_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTR1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="51" mass="5926" checksum="3C87DD99AB4F4547" modified="2013-03-06" version="1">MKIIVLHDASLRRLNMEILVAFNVMIVTLQTCNDSYQKNVFLTQILFNIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTS7</accession>
    <name>L7JTS7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994018">
        <property type="protein sequence ID" value="ELQ74824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2243"/>
    <dbReference type="HOGENOM" id="CLU_598770_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTS7"/>
    <dbReference type="OrthoDB" id="10309540at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="400" mass="46445" checksum="64CA92624AC69751" modified="2013-03-06" version="1" fragment="single">VNSAIEISSIGNSVNNHSKIVIDNFIFAEQVKLADNYERVELDYVFTRGDGEIVLNKSCKELLLRNCSIVVNAQDVENLESLEINFSIIEEYKHRLIGLKSVNHIYFTNVCRNVDSIVTILINIREVKHVRFETTHLFKTYIWSLRYCEVFWEHISAEYYGRSMNLDQIRLTAKNNPSRKFVDTLTNLLTNIILRRVLNEGGMSTVTKLEVMSTVIDENNCKMLKKLQNLNILRICSEHITCNFLRNLPTNLKLLDITDFIENDGLRSTKYTMKPSIIVQPHKNLEILVVEIQLLHNLSAISLLFPHLKVLKVRYSPLIDINPAVRRNKMRVRELLIESSDYQINMCKITNTKPEIIHFLRNLQFYVDFSLLECLALVSQSQSMILNPVTLQKQVFNQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTS9</accession>
    <name>L7JTS9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="JH994009">
        <property type="protein sequence ID" value="ELQ74888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTS9"/>
    <dbReference type="FunCoup" id="L7JTS9">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2175"/>
    <dbReference type="HOGENOM" id="CLU_010862_5_0_1"/>
    <dbReference type="InParanoid" id="L7JTS9"/>
    <dbReference type="OMA" id="MKCCHEM"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="441" mass="50311" checksum="CDC66C7097669EDC" modified="2013-03-06" version="1">MEEKFIKENSSIIKVTHKAFYNPAQEINRDISVMAINAFLDISNFKEDNFCIFECMSATGLRGIRYAKEITEKCAIFMNDIDSDAVREIKENLKINEIRYDMLDDYRNKSVIEKLNEVINKYTSNCTQAKETNTNGVILLNSDCNSVMASNCLFFHVIDVDPFGHFTKNLPFVFKSIKNHGLVCLTATDTAVLCTNRNKCIRKYDVLIRKVPYYGEMALRAALSTTARIAGMYDCGITPLLSLSVDFYVRLFVRVERRTSSVKASLNECAYYFICGCGYTIEHGSKNTEISLFCPVCHNKLLLCGPLWKGKLNDSVFLSKLDNRTESKRVSEILRLIKQENTCFGFYHVPTVCSLLKTECIPIVKLVSELLNRGKKVSFTHCRANSIKTDCQYKEITEIIRSYFKNKDSIADNELAIEICSKKYNRDVIHDNMGPLSKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTU7</accession>
    <name>L7JTU7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Nucleic acid-binding, OB-fold, Nucleic acid-binding, OB-fold-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTU7"/>
    <dbReference type="STRING" id="72359.L7JTU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2576"/>
    <dbReference type="HOGENOM" id="CLU_057562_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTU7"/>
    <dbReference type="OMA" id="KTPRFAN"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="435" mass="49970" checksum="505503226DB411D2" modified="2013-03-06" version="1">MVGVTKLFLRTKKTQPMDNRRLAFSVPQQPTTSIFKNIKDLKINEYASIIVLVKGHLEPTKSKGTDYVTTVDVIDELGDALDIKIFTKTPRFANFFHESDIIRIPSVKLIGKGKAVTGHGSNMEVLAHLNEEGTRVFVTESEKAKINKLREYTVNHQVSCAWPLLKIKDIKEYCSFSLVGMLISIREETPSLTVLLMVDYTASPLIKNIVKNARFCNDMTLYIKVWGNRQEKNFGELRIGKVYRIRKIRTDKLGMTLEARISETFFEPLIPLDEKSPEYQTIIEAKKKFYGDDDSTKTQNVETKIPEKYELFSLCKITDIKAAGVYRIRVKILLHYPFLPIEAIICRKCNFIQSEDYNFKCTTSCKRLLGCTPIKEKILKIQVKDASGFICIVLKNKLVEKFIQLEENLRKENLDCIVLYKNGIFFMLDANFDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTY2</accession>
    <name>L7JTY2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2900"/>
    <dbReference type="HOGENOM" id="CLU_1009007_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTY2"/>
    <dbReference type="OMA" id="ITHPYWC"/>
    <dbReference type="OrthoDB" id="2190684at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="276" mass="33124" checksum="10C3CB6D32820111" modified="2013-03-06" version="1">MSFLINKEREQILKGDYEPKSKFTYMYALLKSQKVKKRKEVDYKKMSTSKLLSSKNYTKKLIEELKQRPFKKIIKYFESIPPLKNELYYWHPSKKINDPLTLLIKMYKQNDLLKKMRVAKCEALIFKCKGFDKFEGMLQERINMNELKVLNEDYNFFGKFWITRKGKTQEFYDYACKMGAVTNKNRKTVDVVQRIITHPYWCDNTCMASFSFLKMPYVKNLDFSVVECHSFLEIEIEDRTVIVSFREFNGLLRKDKKYEAIWNALGVTYEEEIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTY3</accession>
    <name>L7JTY3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2607"/>
    <dbReference type="HOGENOM" id="CLU_004199_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTY3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="997" mass="115961" checksum="7C19CAB8089CF2E4" modified="2013-03-06" version="1" fragment="single">VLDAFDLTDFAEWLKLKFTKERSSFNLTSKKERNTSNKSIKSIDFDVYMDKNTEFNVFGLIIPNDKLCSQIDNNQNMEGQYYISTPLELLFLSYIKVISKFNPCYNLNLRLFIKEENSELTAKNINICRNVSINGIQKILLTRVRIADDQVVKITSEYNSLILEYCTGRFIVPGIQVGVKKYINLQNTTFIQFYRIEEDIYSCKMTGINFEDKLLVSHKIRIAQLENSVLYEDIGLEFKYGCEILHLFDTKGVIISPDNNFKKIILSSYYQNFPVYYLSYPVYEIIISSCTINHQILIFTDSTKRIRLYSVQLTGHSMVAIDHECEKIAIWKTTGRFVISNIIKTSPLRQAILNLRNGVFIFGSNFSKTQCSLLLEHVVIKRRTIVRENVHVLNLISVVIRRRAVLKINDDCEVLLIDSCKGNIDFSGCTNLRSLTIKNHKFIYHKGIYDNLLSLHLENVNINTTLRLGGNIKNVKLVGVTTRLFKSVQIDRNCEMVHVRNFVGSLDIPDLFIYSGKMFTRRMITIAYERMSDTFGGVMFFNDIYLKNDYEIPSNVESLILRNFMTNENARLKINESCKYLKLNVYQGYIDVSKMKSIKKVAFLKYLPIFGDNCWEFSDQCKYPVNKIGKKKINLPINIDNVIIERVNIQSNYSLVVNENCQNVAIIFSEGNFDLSRIKKLASLKLLIEKQGLINIQFPDLSNVTNLEVSFDSNEEYFNLLLSKCINAKKLVLYNVVCELHDWIENQSLLGYKEEMTPYELSELKSIVGAESRAYQCRLSYDLHRNFITHSRPIFDYNRQVIIRDLSIIAFSIDKESLKQLKRFFMLTRLSIVTRTIFAGLFDSLPFSLNDFSLMLIPCHVTVDLGIYAAEDIDSKKKNTKNINLVNLRLHGLFIVKMEQFLSFPDKVDVLEVMPLAMLSDKEIQVRKKMWVKKLIIMQMNSRTREIIRSDYALEEYYNHLLNVLSQYIDFSYLEEIKILDQDTEKLVDPRDYSTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTY4</accession>
    <name>L7JTY4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2110"/>
    <dbReference type="HOGENOM" id="CLU_092857_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTY4"/>
    <dbReference type="OMA" id="GLHLFVW"/>
    <dbReference type="OrthoDB" id="2187049at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013311438" evidence="1">
        <location>
            <begin position="16"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="255" mass="27976" checksum="82D72E517B16F73D" modified="2013-03-06" version="1">MISVLLYFWMSYASYQDVMAPGLPCTIDNRTYNVDWKIHVQKSIVEAIHSVALSNIVAHETEREAIAGYFGTIFDELNQELLPFKVQFHLKLDGYNTDQTMGALSLDPSCEKSDAVSERTSAALTYLNQSFAGNVGLHLFVWGCNFIPPGSSISAFYSSLRCGRVAGIMWRGMKESRENVKNAIVNAIAGFIATDQGPVIDGAKLCAYMQQCVGMQGSEIGQLVEGTVPVFYTDSDSGALPDEKEALMAYNEVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU23</accession>
    <name>L7JU23_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FY-rich</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994000">
        <property type="protein sequence ID" value="ELQ74983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2081"/>
    <dbReference type="HOGENOM" id="CLU_112148_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU23"/>
    <dbReference type="OMA" id="ISCDYKK"/>
    <dbReference type="OrthoDB" id="2192852at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="214" mass="25530" checksum="DCC620F483CA66E1" modified="2013-03-06" version="1">MLFSSELQKLFKEREELYVKKELTYNKLKERIKREGILTHILRLNLRRPVQKVTHQPIILGSSLYRMSVLNVGELPKPSQKEYITPTIVYPINFISKRKYKKYNGCPSKSKDKIFYICKIHDNKDMFEISCDYKKWVGKDCWNEFVKDFDAVSEYNSMEEFFGLKHPQLQRIIEEKGTDELTEYVPLNRRKENGKTENEMSDVSDDGRFYSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-03-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUE7</accession>
    <name>L7JUE7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994044">
        <property type="protein sequence ID" value="ELQ74377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2704"/>
    <dbReference type="HOGENOM" id="CLU_2172831_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUE7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="14420" checksum="B07FF7C50D9DCBCE" modified="2013-03-06" version="1">MTLLNFDMKPLFVSKYTICTWDENITFNRISTNYIIVEMICQQPSIFKRALRKRVLRILNQKAFRFAGMSKLKEAICIHIYKLDERDLRLMLLTVHAIYKFIRLRFVKKCMTKVIKCSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUI5</accession>
    <name>L7JUI5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993994">
        <property type="protein sequence ID" value="ELQ75084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1980"/>
    <dbReference type="HOGENOM" id="CLU_3320321_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUI5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4720" checksum="6214387170083BD9" modified="2013-03-06" version="1">MPSSCQNISYDKDTINFLRNEQHHYNLLAQYEKYAPKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUJ6</accession>
    <name>L7JUJ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993999">
        <property type="protein sequence ID" value="ELQ74990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2074"/>
    <dbReference type="HOGENOM" id="CLU_2967568_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUJ6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6618" checksum="850914B24B7C4AAD" modified="2013-03-06" version="1" fragment="single">VSSSVFVPSIGLDNFFFYIFFEAVTGEVSKMYRHGTINKLRNCSLSVSGLLLKAHWSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUM7</accession>
    <name>L7JUM7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2567"/>
    <dbReference type="HOGENOM" id="CLU_814316_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUM7"/>
    <dbReference type="OMA" id="TEEYEWK"/>
    <dbReference type="OrthoDB" id="10614189at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="346" mass="40867" checksum="A426203C354D7184" modified="2013-03-06" version="1">MFVFNKTLLETSEPEEEEEITYRREDDEKKQIQELARRRTNVLQTNEHLDNEKKILDKERMSSVQSKLRRRRKKNYDYSELCCVGGVDCDLAAETDFEEYLNYVRNKANSRNGKKTTKYDIGHLHNPVRWMPLKTNTKKATRTFHIGSSDESDRYYRNRYGSNIASTKYDVNDRHVLGGIQRYNYGARIAYNHVHQKNGCLKKDFRHNQHNVLDSYYPYSSFSYASSDQLNTDLSDSSSIPDVMDSSSESSSYHKYSRSTTPEKPDNAVPMVDENYMIDLSEVKNFQRRKVPYWVSILQSEAFQPVADLVSRLTDEEKKEYVMEMMAIFDLRTMEYRKGYKKNKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUS1</accession>
    <name>L7JUS1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUS1"/>
    <dbReference type="FunCoup" id="L7JUS1">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1831"/>
    <dbReference type="HOGENOM" id="CLU_000688_6_1_1"/>
    <dbReference type="InParanoid" id="L7JUS1"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="192"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="415" mass="47150" checksum="44D91646252C4CC7" modified="2013-03-06" version="1">MSTNDRELELGKDADEFLYYGQNYYTDEIQKIEKLINETFDRVNVKLGTKEAETGLAPPTTWDLEGDRKRTENDHTLQVARVCKVLVNEQNEDCYMVNLRQMAKFIVGRGHEVDKTLIEEGMRVGVDRMKYQIILPLPRKIDASVTLMQVEEKPNVTYEDIGGCKEEIEKIKEVVEAPLLNPEKFVNLGIDPPKGVLLYGPPGTGKTLLAKAVANRTNACFIRVIGSELIQKYVGEGARMVREIFELGRRKKACVIFFDEVDAFGGTRYAESDDNEVQRTMLELINQLDGFDNRGNIKVIMATNRPDTLDPALLRPGRLDRKVEFSLPDLEGRVKILKIHTRVMSVEKNIRYELIARLCPNATGAELRSVCTEAGMFAIRERRKAATEKDFLNAVEKVIQGYAKFSATPRYLTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUS5</accession>
    <name>L7JUS5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1884"/>
    <dbReference type="HOGENOM" id="CLU_1385051_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUS5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="22699" checksum="804E6F5ED1814D6E" modified="2013-03-06" version="1">MTQKQNISESSSTPSTKILNVSTELDTCVERSGPYLIPFLLAVFVIFILGLIFIIRRTKKFLKFSYPESLVLSTERQRNFTYDPSIVETNVFSIDRVEDEIDELMVDSIFDQIEHNPSYFAPSSNYITVFDEFPNSNLDESKIMPQAVQKPNEMLEDKSNSKDLEQEYVSRYSNIINSNTECISAFHNDDISFSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUU2</accession>
    <name>L7JUU2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1856"/>
    <dbReference type="HOGENOM" id="CLU_1476148_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUU2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978877" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="183" mass="21533" checksum="7A86D0641F415861" modified="2013-03-06" version="1">MQFLRLFLTVFAACCMFVYEDTKEKDKEKGEVRNDKEIVNESVGRSLELDELKKLWSEYCSIVDDLCDEFNLRVLNMELDTIISELEEMKISIKMNYDGPDGENSIFLMRHCDNILDLKEPKLLTSLESLELLFQITFNEIDYIMKLQGTTKLFYDLKDEIEKYASYERSCKALAKFEDSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUU4</accession>
    <name>L7JUU4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar H+-ATPase V1 sector, subunit H</fullName>
            <ecNumber evidence="7">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="7"/>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUU4"/>
    <dbReference type="FunCoup" id="L7JUU4">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1900"/>
    <dbReference type="HOGENOM" id="CLU_689259_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUU4"/>
    <dbReference type="OMA" id="LEYACES"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="285"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="400" mass="46941" checksum="867D42E66AC2A329" modified="2013-03-06" version="1">MTDNNGKGLSAALKPCKKQKEDRNEVQIGPLHDLQSADKKTRLKALYTLCMDAETYMNDIIEYFVDVGEAKALKEVNFCLVCMRKLFMERLERGTEDKFEMEHLEYACESSTDSTPMDVGSSCTSEYEIRITATAPKRPPHTPNTERFIPFSEREHGYANVTDRRMRFIKDERVRRILIAMLSIRNVQYNASIILWYVSFSKETIEYFELIVPHLLHLLKTRECEKMVRTTFFIIRNLLKNGFFFSLVTCHDIINDTANMKYEDEELKSTIDQVARVLKSRLLKTSSFQNYLRELFSGKLENTPYHFSDVFWSMNMNSLIEYKIEIIRALKKYLKSGCTQHKCVAANDLYRFVKACPEIVRIVEKFDLKTELFKLCESTNDDLRFYALQSLSVCIFQEWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUV9</accession>
    <name>L7JUV9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA thioesterase</fullName>
            <ecNumber evidence="6">3.1.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="6"/>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUV9"/>
    <dbReference type="STRING" id="72359.L7JUV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1934"/>
    <dbReference type="HOGENOM" id="CLU_963455_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUV9"/>
    <dbReference type="OMA" id="PISYHIN"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="5">
        <location>
            <begin position="258"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="327" mass="37641" checksum="45059040098DB97A" modified="2013-03-06" version="1">MSLFDITRHSDNTFTASELWPPFPSYPAFGGHLVSLFLLSAMLFRNTKPTSVHTYFLSPGEVGVPMNFEVTMLKEGQTSKFVNVKGYQSKRLVVTSDCLMCNTADGAVIYQDDIEVYDDVYVHLSTHFTNLWRIGKTSNHLNNVATNDTLPKNSNKTQYDTLHSNVDDIIKKIEENYKKLDKYFSIYIGRPNGVKRQFKIVLKTKNINFSVLVAFITDLFLSNSSLAWIRNKYTMKTYSNSDLKIVRIQNEHEWNHMDTVINMDSIQRMSLDHKIHFHCNKFHDELIFVTKCQFIGEKKVLFEGKLLSREGVLVASVTQEGIIAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV76</accession>
    <name>L7JV76_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Heat shock protein 70 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993983">
        <property type="protein sequence ID" value="ELQ75190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV76"/>
    <dbReference type="STRING" id="72359.L7JV76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1867"/>
    <dbReference type="HOGENOM" id="CLU_1682195_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV76"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="17644" checksum="03DD9DA80329C719" modified="2013-03-06" version="1" fragment="single">VMWTTTAFWLSPAREKGSNKSEKLTVSNSNRKTTPEQLEEMHKKHKEFEEADRKKKENVSAKIEYEAMLYQLNEKVGEVPDQNVKSNLESSLKQHQEWLDTHPNADKEEYMNKKNELMGLLQQVAGSAQGAPGGFDASNFGGAPPHGASEPKVDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV78</accession>
    <name>L7JV78_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1715"/>
    <dbReference type="HOGENOM" id="CLU_004707_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV78"/>
    <dbReference type="OMA" id="VQPYIND"/>
    <dbReference type="OrthoDB" id="2193594at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1078" mass="127352" checksum="F9E09620BEEE9807" modified="2013-03-06" version="1" fragment="single">VLKSFNPFNYRIETSLKIMKEYGIGDWSFYFTCLANYKNLKSLFLDYYMKEQNIPEEVVQRQSHHDKPADTDTVIYYALGKIYMFSSILVLELNLEFLTADVFKTVIGLNSALDSKIYLFLKKENFELLKQLIDCFDKTPDSKLTALLKGKKVELQDLKCYLSYDIDFTIYDIQTFFDIYKHGLDENGIRILLQYDNDEDVFKAFQFLLAQEIGDVFKYFNRQNDLIYQYLRNNDLKLCFEYIKEHEKYKVAFLESVDASTCCLEEARIAYDLLDRTLTIDNELTSVKPVDETEDIVIFTKYGSAVTGRLRKTTNVRDGNLYYKCIYNDVTCLIKEYKEHDIVFILSYIRPKDVQPYINDLFSYDSRIIQIHLRDKFYTFVIAQQIECILNERKNEEHLILILENVDKIRLPTLIRLYHHQNKRISDLSLHRLKRLKILNRNLSEIRLKIINYLTDKDMSSSFIDNIVFTSELDRESLEICILLVKKSKNMILAERLLCLTKQSHICEYLRDVLDVLSNELIIKYVNELKYVLKEGDLADFLREKIEHPTLENAKLVVKVLEIMEMDVNVVLSEKDMIELKSIVAHPNGLMTDDERESGTNSGMEKNIRAEKYVYDDSFSNNSETMRKVTANAVIYKLFLPTAYAPVLPSFHKYIRYMLSVVFSEFCFENKVSVMCLISIIESTNAFTWRILQFLKRIASNTTSNNKQRILEIIDLIYNKYLCNHDESEQKQVESKNEIERQSKEFMFGEILFLTLLLKNDNNTVIAKEFSRFFGKIYGPRNIKKYFGVIIQNLNNFYSVNVADEMITKYKAELVDYIPYLGNDFLIRCLYNGFMTKEIIKIVFEEQKMAVIKYILENEKEKIELSEMIETSNFHKNAHLFDDETLAEMFFINYDRDIIKFLRNTDVLYIRFLELSTHRINDQRFVQEYNMLKKKLISILSSNAHIEELLLKTNKAMIIDYLTYQEVVVDHGNLKTLISRISDDCTFLLGKVHINYLLFLNINLIVKYLSKEHFNIFKERLCEITDRKSAALYSLRCYLDTSLRPGVVYCLKRINYQPEIGEYDVLEYYVRNILKASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVB4</accession>
    <name>L7JVB4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVB4"/>
    <dbReference type="STRING" id="72359.L7JVB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1666"/>
    <dbReference type="HOGENOM" id="CLU_293589_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVB4"/>
    <dbReference type="OMA" id="TESWEHM"/>
    <dbReference type="OrthoDB" id="10426565at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1065" mass="125602" checksum="E1AFF905695AEE8F" modified="2013-03-06" version="1" fragment="single">VMKKNELIKYALKAEESKIKLEGKDNECYLYLPTPILELNNMFGPEIKGKYAKINAKNFFIQKRKCLIERNSLDYALFYSLLRELREVRDGWMNGDKKDNNIAPSIENGGIEEFAAQTKKLDSDGLSRGNCPIEQSNLNTTSRKSRTSRKKAAFIKSWYGNSRKKQGKKLFMIDIADPLIVISVLIETKHFASFVYMEKDAININGLKLNKNTNWHKLFHFLLPRAGSNGIRNVLNLYDEKLSVMLYVQNKNKDDILRHMIFCNLDLARKIVLFYNNIGKEICELYVTECEKKENKEWVIEYLNNSLIGSIGPNLLHLYTKYEKEINLTKIAEIKDYIDIAKKEEHLKNNDVIKQYEEVYSFFMSTEGMTSNEFRVKEVLSLELDEEVASETKKMLCRLVKSNVEFIANELSKQNTKSRRTVMRQIVTESWEHMLCMYADLVCTQDGLNRFIFECELFVYIVEANSGTMPADTNERAELERKNAIKMRKAAKFIDVLEFKNPSKSILLNMLRTYLERCLQRKRYGIIGVLRAYLNKRSDFEYKLLQNFRNCIFRMSGVRLKQKIALVDLYYELIEENNRKQRDMSINFEEIMTMSTGNPLNYGRLTPLEIKHVKFGPDVIKYIESFRGKVFERFFDAKNFILFTNCFLSNLTDLGWIENSLLSIKSTREDLNVMVESLISQVKVRRCMLGDVIAVSDNKEVKNGSIPVNDVERLKTAENEEKETTRNDEMRKQPTLPAEDAKQTGVAVQEKEEGTDISRITEQNDMRKTSESSSAYQSRYCDQKNVPKNYGEYMEKEIEPGEIVCDKKRICENNYERGRNADYHYDASFQYDDRTDSINREYHRNGDDRGIDRQASGWNEERIERDTSRNVSYMHRKDEWRENGTSRYLDRMKEYYDASPRGYESRNDSCRDSGYEVNHRASSHRTENERKKYLDSSSLSHRRGNYRSSYLSCNEYGREPCSNNSWNAQNQMKHSQRKQESSHRSRRIDDELGRDEHDDRERSSNDQMYDGRMHDRDRMEHPEYNDDTRNYNRRSGYSWSRYGRRDQDRPSDAYLNERARRRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVC7</accession>
    <name>L7JVC7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2369"/>
    <dbReference type="HOGENOM" id="CLU_2361225_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVC7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="96" mass="10708" checksum="D9853E263A9548B7" modified="2013-03-06" version="1">MVTQSVSLVNTTSTARTPLVDLFSSLDSDVGMRIDPNAYIIGIFLSVLFIMVGIVLLFCMLKSKKLKHSLDKPGNKFKGARGTKYRINNGFIIRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVD5</accession>
    <name>L7JVD5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Microsomal signal peptidase subunit 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1687</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVD5"/>
    <dbReference type="STRING" id="72359.L7JVD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1687"/>
    <dbReference type="HOGENOM" id="CLU_142364_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVD5"/>
    <dbReference type="OMA" id="ICIFTYI"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18167" checksum="1DEDC41E2589B14E" modified="2013-03-06" version="1">MHSVSSRIVALSSILFNATTILLFCICIFTYIADKRRAPCNLQIVSIQPVTTHNVGKNVVFNPQIDLREYFHLNVKQIFVYLRMHNKNNSEMVWSEIVKKNDSKRFYERLVNTYRFFDIADGAKIRFELRGCVFPYVGIVQDKLLGSVVTTVKRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVG3</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ75419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1612"/>
    <dbReference type="HOGENOM" id="CLU_588187_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVG3"/>
    <dbReference type="OrthoDB" id="10281556at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="465" mass="52908" checksum="CA4AB617FD20C674" modified="2013-03-06" version="1">MRVMPNKRVKSNSGASPYAHDSTYILHDKNVLDNEDKKSLFINDPLMTQYSKKVFLKISGLIGSTRSTDIPSYDHNTNNECTNVINDYERIGTRGTDAKNEYGNMISIYSDLKRVMDAMAMYRYENRNKDGSKEMDEVIEDSQYVEDLFRNVARNMVVKYTRRNVGCEMKEGFYLCNECMERYVMAERYHESRSVVKKNEDVLNKADKNEDDSVKVGGTITQKNAVSDIKDDGIGYKTDEVENNGVEVVQTGKDLKRVVTANENTEKDLNKVEKAEEETLEEKEGVAKKELPEWLVNGKAADLNGAKLQGKVSAMDKMEEQTAKDMNGKENIEKALKVVNMAMNITKKSEKELNTNINGEIVNEITKVNEMLEKKDNSKQKTDESVTHSGKKRCLLGERTVGPPHFKIKVVRNNKDGDYFVYKPEPREKKSVLLGFEAITNEILKENKAFNTFQGGIKMRKGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVJ4</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993960">
        <property type="protein sequence ID" value="ELQ75449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1603"/>
    <dbReference type="HOGENOM" id="CLU_1950312_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVJ4"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="129" mass="13493" checksum="01DE4935FB096D2B" modified="2013-03-06" version="1">MPSNRVKQAGEQNSSGSANHTPGIILADPVEQADERHPLGNSNHAREPNGNRDRSPTTLRRKTPGDEIDRNHQENDGEGNNSENKSNSGAANGDGVSSEAVGENQTPESVVGLDAEAQNASETSTAGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVK7</accession>
    <name>L7JVK7_TRAHO</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1561"/>
    <dbReference type="HOGENOM" id="CLU_3282352_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVK7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4763" checksum="A92D039F7FB4B923" modified="2013-03-06" version="1" fragment="single">VYALLKNYAVTKVYALLKEYALLKNYALLKEYALLKGIRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVR9</accession>
    <name>L7JVR9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1642"/>
    <dbReference type="HOGENOM" id="CLU_1826643_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVR9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="141" mass="16855" checksum="0B238419ECEA6474" modified="2013-03-06" version="1">MLVSCYIIINLGIVVMEDVDLKEKNTKNINRLDLRLYGLCIMGRNQFRPFFKKINVLNVMPLVKVNDKEIQVRRRIKRLITVKINSRTRKEVCKDYLLEEYFDHLLNLLSQYIDFGSVEEIKILDQDTEKLVDPRYYSPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVT5</accession>
    <name>L7JVT5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LTR Retrotransposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993946">
        <property type="protein sequence ID" value="ELQ75539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1505"/>
    <dbReference type="HOGENOM" id="CLU_206113_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVT5"/>
    <dbReference type="OrthoDB" id="2192994at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="6939" checksum="18285F1A4A67528D" modified="2013-03-06" version="1" fragment="single">VSNLMFLNDLTEKYPYKIPDMKRIVKATTGSNNLTVLDLKESYYQIEIEEADKHKTAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVV2</accession>
    <name>L7JVV2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1881"/>
    <dbReference type="HOGENOM" id="CLU_511096_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVV2"/>
    <dbReference type="OMA" id="KIPRECI"/>
    <dbReference type="OrthoDB" id="10393380at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="533" mass="61011" checksum="67528F1F34544EB8" modified="2013-03-06" version="1">MPCNISDLSIIKQRFIKKVLPKSAEIIFKIFIISNTISNREIHDHTVIDPNIIVTTLTYVFTWLLAECEITYGSLSFMRDVFVHSTKTVDSCACVYTHCVLVFSITKILCSLACMCRFTKILLKIPRECIVGCSLATGAIHVANEIKMYNASITLPSFVLSAFFALFFLHSKALFVILVVAVTVSNHLVVACLQKHEPLFFERLQCNSWDVLWPVHYFDFESVRARSLTCSFFSAFAIFLFNGIEIELERENNEDISGGGHKEQDSGVVADIASITYNGPPALPANEVISSGLPDNAHVTYPNAIQSSISRTRPPTVLCTSKLYRENEHSFINLFTFFLPFTIKHERKQFYAIERVFISVLTLNMAVLLLLFRLFIPKIVYIGLSMFLGVYIIVMSLKEVRKFSIIERITIVCLGIFNTAYNMFVLSAMLLTGAIYLVSYMRNSNTHCQPVDNSYSHIVYEYEMLDANVKGEIVVIDLRRYNYIISNERERIGNLVKRLRVKNIFVMKRKNLFIRLENVNFICELSEIWEYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVV6</accession>
    <name>L7JVV6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="3 7"/>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVV6"/>
    <dbReference type="FunCoup" id="L7JVV6">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1639"/>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_1"/>
    <dbReference type="InParanoid" id="L7JVV6"/>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="10">
        <location>
            <begin position="448"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="590" mass="66728" checksum="6ABDE9F59FF4384C" modified="2013-03-06" version="1">MSKKSKIALLTGTVVLSYVMYNYFDKKRKKKMVEELNAHPPLSWKPSNRNTTIHNMKTKYYDVLVIGGGASGSGCALDAATRGLKVAMVESGDFACETSSKSTKLLHGGVRYLEKAVKSLDLSNLQLVLEALRERKYVIDAIPYMAKPIALMLPVYSKLMVPYFLVGLKMYDYFSWNKSLGGSHHISVKETLQHFPNIKLDGLKGSIVYYDGIHDDSRTNLMIALTAAYYNADVLNYSPVTQLVKNDGAVVGAVCKDMIGGEEFNIRAKCVISTTGPFTDQTKELANPKSQSLVVPSSGVHIVVPKEYGANDMGLINPNTSDNRVLFFIPWLNKTIIGCTDKPCKVQKEPKPKDDEITYILKEANRFLKEDKILKKSDISSVWCGIRPLVKNPARRDTKSLARNHITYLTEENLLVLAGGKWTTYRKMAEDAIDLAVKKFHLNPIRPCVTNYIKMLGSHNYTKQLSADIQRELDLNEDESTHFITRYGDRSLIFQNYKDRKAPLKKLHSDYMYTEEEVYYAIDHEMACKPADVLTRRMRLGFLDVKACEKALEKVMKIFKKRMSWSAAKTKKGEKECLQMLESLGLKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVV9</accession>
    <name>L7JVV9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994009">
        <property type="protein sequence ID" value="ELQ74887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2174"/>
    <dbReference type="HOGENOM" id="CLU_3360012_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVV9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979187" description="Transposable element encoded protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="36" mass="4372" checksum="141F5E64C84C75CC" modified="2013-03-06" version="1">MTIEAFSLWILNLIAALDFYVDPNKMWSENKCFRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVW3</accession>
    <name>L7JVW3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVW3"/>
    <dbReference type="FunCoup" id="L7JVW3">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2138"/>
    <dbReference type="HOGENOM" id="CLU_112964_4_0_1"/>
    <dbReference type="InParanoid" id="L7JVW3"/>
    <dbReference type="OMA" id="QYYELYR"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="10">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="117" mass="13454" checksum="079E46E00DAC4F6A" modified="2013-03-06" version="1">MYEFYRQSIIGKALQDTIEDMLSNSQLTPVQAKLILEKFDQAVPVVFGRTVQSNMNFKGGVESYNFVDGVWNFITRDFVMTINNKMVRCDYVKIVACDADTSNDSGRKRRKRNVGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW15</accession>
    <name>L7JW15_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor of the Forkhead/HNF3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW15"/>
    <dbReference type="STRING" id="72359.L7JW15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1552"/>
    <dbReference type="HOGENOM" id="CLU_1876888_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW15"/>
    <dbReference type="OMA" id="ERYAGDM"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="3">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="136" mass="16351" checksum="668F1176175FF825" modified="2013-03-06" version="1">MPKNIRVHKDFTYYTIIKEAILSSPHKKLTSNQIFQYIQNKHPNLFLVSNSMTWKGNIRQLLSKNPEFVKIRKEKSAKLHYWMFVPRREIEMMEKVEDRVWERYAGDMKDRVLCLAPECIIDLEYENENKKGSNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWD9</accession>
    <name>L7JWD9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1396"/>
    <dbReference type="HOGENOM" id="CLU_098346_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWD9"/>
    <dbReference type="OMA" id="IDYVNAD"/>
    <dbReference type="OrthoDB" id="2191916at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="229" mass="26520" checksum="DE86706130EA105A" modified="2013-03-06" version="1" fragment="single">VQMQSRFKNLLRKVDRIDYVNADFPAGYEKTEEDYRIVKNKMENLKNTFLHFMTYEHGGHAYKTAMRAIEVVGRRVKKDSFEVRSFYKETELTGREIAKVQSNDALKSLAEKYSDAFSAVEDAKVKMNEEYEDIIKHIKELQESSRAIDEKRANVLNLRYDLEKMYKKKSPGNEELDNLKAEFNQEANLIKEEMKGYVGGKGVSEVIKRACKAMATFSKEISTALETVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWT8</accession>
    <name>L7JWT8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1139"/>
    <dbReference type="HOGENOM" id="CLU_1662040_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWT8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="159" mass="18132" checksum="3E8947A6458570E4" modified="2013-03-06" version="1">MADINELYVNNPALSNDKEEFSADKSSRNIKRDVSKALERRKTENSYNMTCIRRHRKSLSCQPVSGKEYDLEQSIGIDVKCPRSRNLKKKCKMVAYSHGNRSRNIKGLKMRCKTASSKDYKCVANFALGESEYNVDSGSREKSEFELNCEVNWAGFLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWX1</accession>
    <name>L7JWX1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1095"/>
    <dbReference type="HOGENOM" id="CLU_1088039_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWX1"/>
    <dbReference type="OrthoDB" id="10527761at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="256" mass="29736" checksum="D375FBBD79230031" modified="2013-03-06" version="1" fragment="single">VMIELIIYANSLEYAQIAQKCFDKFSSVKDTLRFKLIKKNEVLSGLDVYTEETSMGDQTLIENKKLDVEEKHCGNDRIERQKLEKECVDIHPPNSVGNYNESDDNRMTRNRKIDENEKVKTRVAKSRKRSKKNIALSNGPGHGGTTNIVVKTQVNKHGVKNLVCVVIVRKGEDFDGYYDFLIHEDECTGFELENVIITIYNYKKILIQDLKVVDENNNRIKRDVIFYTKNVPYLVVENVMKLDKKNTKKKIYLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWY5</accession>
    <name>L7JWY5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Class 2 transcription repressor NC2, alpha subunit (DRAP1)</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="JH993942">
        <property type="protein sequence ID" value="ELQ75571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWY5"/>
    <dbReference type="STRING" id="72359.L7JWY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1475"/>
    <dbReference type="HOGENOM" id="CLU_1612068_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWY5"/>
    <dbReference type="OMA" id="EWEKSMT"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="88"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="166" mass="18630" checksum="54B184CB46746DC3" modified="2013-03-06" version="1">MARKSKNTKKEKRPKKAKINEPVAQESTNTAESNDKTECSVSARITDEQKCSTSTQAEDSKLTNGSNTNTSACSSVSTLALDKKKRFRFPTARIKKIMQSDEDVGKISTYAPVVLGKATELFLFELVNAAVKLAESDKRKVEVEDLERVVKENEQFIFLKSYRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX05</accession>
    <name>L7JX05_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1068"/>
    <dbReference type="HOGENOM" id="CLU_3320319_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX05"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4313" checksum="97209E56ABA3807D" modified="2013-03-06" version="1">MCGGQSSLKVLTRYLKGDIVLFGDGRCNRLENEWAVIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX13</accession>
    <name>L7JX13_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-tubulin folding cofactor D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1763"/>
    <dbReference type="HOGENOM" id="CLU_009878_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX13"/>
    <dbReference type="OMA" id="QIICLEW"/>
    <dbReference type="OrthoDB" id="2191705at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="743" mass="86755" checksum="CD6AE041BAADCE1E" modified="2013-03-06" version="1">MPEVVEDVLLKTIFFENKNKHAQRMRETALFLVYCMLRSSFNDEIDDDNCVDDGMLSVDHQCSVITLRFLKNVLLSVSLFDNQLECRRAASSILIDLQARKKIEFLPFIDFYSVKRKNNVLNLPQEHYKGLLEQRMTRKIFDYDLEMQIICLEWMKRHRKGITLKKTIKKDEYNLCDLVERYDLREGLGKQEGRAACTSKDCNTDAINEPISYTTALIAYLFLNQIEKIQIDFDEFLLEDKKFAFFADAYLKSTIFKNFDFKGECSFYDMVENVITPNNRRVSSHSSPFKTYYIDYNTENSVNDQNLVFLLDNNSCPHLTMFLYSTLDSDFLFKRLVKRRSLSYFLINVFNTKYFAEYLELVKGMLNDRDVERTRIGMNCIYMMYRLYGDTNVGKEKDDINVRKETDKDDINVGKEKDDINVGKEKDDINVGKETDKDDGKNILYELLYHAIDTNLNNYMINYKGDVGYQCRKESFFLLFYLKDQRVNYYIIKYLFDKNKELREIVISFLREIGVFKNVKGYKTVYISGRRVCRGVEHLLSSAVKEDDNTRPGTLNNDTNSDVSLRSSAGRYESANLHGTLENVGAADCSLIDDSTASFLRSVDTEYENVCSTMSGEKALFKGAFLNFSILEMKHRAGFTKAILSYFVNCDGSIYEILSWGINKYLIDYLVYVLKGTRREIYYVLRSIIILLDHSHQIDSNLQNDGLTNRIRNVQELRTCICGINDEKLNGMRDEIIQKMQWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX14</accession>
    <name>L7JX14_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993917">
        <property type="protein sequence ID" value="ELQ75845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1197"/>
    <dbReference type="HOGENOM" id="CLU_3130049_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX14"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="5577" checksum="1E53700E5DD30BBB" modified="2013-03-06" version="1" fragment="single">VTSITSGIVKLSSRSEMYFARIDRLNDMVTLSYGESVHVLKRTTATKENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX37</accession>
    <name>L7JX37_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7 9">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_1164</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993910">
        <property type="protein sequence ID" value="ELQ75870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JX37">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1164"/>
    <dbReference type="HOGENOM" id="CLU_009673_2_3_1"/>
    <dbReference type="InParanoid" id="L7JX37"/>
    <dbReference type="OMA" id="SWCEDAN"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="12">
        <location>
            <begin position="313"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="584"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="587"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ75870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="801" mass="91514" checksum="3BC61126223388D6" modified="2013-03-06" version="1">MFLTDNLTIMPLGAGNEVGRSCIHITYKSLSILLDCGVHPAYTGTASLPFLDLINLSTVDAVFITHFHLDHAGALPYLTEKTAFTGKVFMTHPTKAILRWLLNDYIRIINTNTEIDFYTEKDLSNCYDKIIAIDYNQTVIVKDFRVTALNAGHVLGAAMFMVENERFRMLYTGDYSTEEDRHLKGADTAWIGKYGQKDEEGRYDTIDRYAQKDEEGRYDTIDRYAQKDEGGRCDTIDRYGHKDEGPNDTTRPNKCKKTRDNEHHLDVLICESTYGVQCHLPREERERRFTQIVNDIVTRGGKCLLPVFALGRAQELLLILEDYWERNPQLHNVPIYYASALANRCLSIYQAYTHMMNLKIKKDAFTFKHIRNLKSVDNHLIKNACVVMASPGMLQSGLSRELFESWCEDANNGTVIPGYCVQGTLAKEIMTEPKEIVAMNGHRLRLNMRVEYISFSAHVDYVQNTSFIEKCTPMIVMLVHGEVNEMMRLKAALEKRHSVLALKNGEMHEIEVRRESVAVGKNLVEGDIEGVVVNEQSGIRVYRRDELSCDLYQEMKILGCFNEGDEGGSRXXXXXXXXXXXXXXXFNEKDHDEGAKDFDKDDEGDKFNDGGRSNDKGNNEEEFNHSSKEEEVNNTKEEEVNHNVRKQQHQTDNPLNDNLNLLTIKNTFNATPSLIKQHLLHFFPFIHTNDNSLSIQDIKLIIENEIVLIYRSTYVNDLLACTIVRLIERMATKDSVKISKISKKSAIVKVLRNYYEVVENSEDVEICDGGRRVVISEKGIRGCESLIEEVKKIIKRVVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX45</accession>
    <name>L7JX45_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dual specificity, serine/threonine and tyrosine kinase</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
            <ecNumber evidence="9">2.7.12.1</ecNumber>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EC" id="2.7.12.1" evidence="9"/>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX45"/>
    <dbReference type="FunCoup" id="L7JX45">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1432"/>
    <dbReference type="HOGENOM" id="CLU_677183_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX45"/>
    <dbReference type="OMA" id="MEYEINP"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="99"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="407" mass="46261" checksum="D877220A5EF052BA" modified="2013-03-06" version="1" fragment="single">SENKISCQIEKDDYTLSVTESLNKMMNSRLKRCGFDGASNGSAISTGNDRKNTANDTKLGVGAGSTTAAVVRTVRRSIERDLGTTTKNTDKIVLNGKDLQVLSVIGKGGSSKVYKVSHGSNVFALKVIKNVTDRKVLQSYENEINLMIKLRGTAEIIELHDYAINKDEIGCTILLLMEYGECDLTHFLKTRELRTSDIFDIFWQMLMNMNAIYDQRIIHADLKPANFVICGNKLKLIDFGISREIRTDTTNVIQESKVGTINYMSPESLCGNKTSRRSDIWSLGVILYEMVYKRNFMDGMNCWQKIDFLKGTEPVQFPDENTGDSMLEMLKGMCAMCLCKEPEHRPTVKDLIYLVKEHRDAVRVRGRDIKALVHRVIETVERDRLNGHLLVDQMVDEFMEEMRKENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX52</accession>
    <name>L7JX52_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993907">
        <property type="protein sequence ID" value="ELQ75885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1149"/>
    <dbReference type="HOGENOM" id="CLU_2783032_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX52"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="69" mass="7866" checksum="C9DF3231FC3105C5" modified="2013-03-06" version="1" fragment="single">VFSIITYNYDLQKALDILSKSMSLAQLSIDGKYESLYVLSIFKCISRMLVVNEGYLLILNMLSPVNENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX91</accession>
    <name>L7JX91_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DENN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993886">
        <property type="protein sequence ID" value="ELQ76049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0983"/>
    <dbReference type="HOGENOM" id="CLU_547667_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX91"/>
    <dbReference type="OrthoDB" id="2190070at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF0">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cDENN" evidence="1">
        <location>
            <begin position="228"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="498" mass="58666" checksum="F655E248B4F1C46E" modified="2013-03-06" version="1">MVQTILNGVFAYQAKESEEIQAEYYVKSVLMWDVTKDLEDNCFFVVDTKNNVCVFDYVTKDEKRNIRGKCYLVYLTGTSYNFYNLVETNENYGTFILINNKKYKLSEVSNNHEIRVMENCESFETQFTESCHISQSDNTLSNVSTFSRNSELICNSVVYSENNLNYFHSRALKYKKYEVQWKICRDESLETVVQKYLQTFKFNNHTRINHFLMTARNEEKHYCSIVSNRNGSIIVISMAEYYLSSDYISIILHNEFNQGSTRISEELLQTKLLKPCKIDIKTSNSSFSISTESLPPKIDLNYNFVLKILSCFLNERQMIFCSNNKEKVYNTIVFFITIIKPFNYGFFMSSRLPDEFREILNSPFPFVLGADERTNSGVVHVDLDNYEMFNFTGDVLPFEKELRKKFRIGARENINVNYLSIFRHYFTIIQNNLDIARETLINKNLKDSLGIRNLIYKPEIIKKEIKYLNDAFTQSFMETRIFKTISVVERTILCWITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX96</accession>
    <name>L7JX96_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-specific protease UBP14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0928"/>
    <dbReference type="HOGENOM" id="CLU_570100_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX96"/>
    <dbReference type="OMA" id="TECERPK"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="243"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="479" mass="55490" checksum="0DBD5023493DFDB1" modified="2013-03-06" version="1">MAIPNINFYRTECSYCFRTSSNDYIYACSCSVPICSLHKSVHTSKPGHKLIFSVQNDVLVFESEYKQKLEEEHEDIGQMEEHLLRMIRLKGERECCSHSTTPQKIVYNETRCLSKKMKCDVQDLWVCFTCGYSACGRKQVYLEGNNHMEAHYKESKHSKAVRNDMIYCYVCEKYVYDVNFDDVNKLVNYAQIKEKNAAVYEMIREIVKLNEEQKDSLFNVKEIDYELDYEEPDQKSVHIPGYKGIANNGNTCYISCVFQLLAHILCFTTFHFLKCSANPFSCLLCQITRVCRELKSTEKSLKELTENTGTDYINIKDLIRCLQRDGLVIDGVQQDFSELLFLVLERLRSEEMNEIECGVNELLIGLVIREWCDGCENEKLSDSEQYFVILSEKPQEKDECKNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNKLKSWTNTLLAKNFISSRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXE6</accession>
    <name>L7JXE6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993890">
        <property type="protein sequence ID" value="ELQ75990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1042"/>
    <dbReference type="HOGENOM" id="CLU_608594_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXE6"/>
    <dbReference type="OMA" id="CFYTMLV"/>
    <dbReference type="OrthoDB" id="10622025at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978854" evidence="3">
        <location>
            <begin position="30"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="457" mass="51347" checksum="08654F2F88E7B715" modified="2013-03-06" version="1">MLNKTHMQAPKYCFYTMLVLFASIGIVFAEPDADEDVLRGGLEGLYERVDEVTQGNNNVLYMLASLLPVTTSTDLIESMTDTVAKIANSYDIEGKDGFDDSTETKMKTLLEKAVDQFKDGKPSDKSEFTEMTKQVMSEFHNMVKEIVNKYRSPQGAAAPLQVSTERISYLFHDLNVAIEDEADGIVEGFDDACETLIDLLEELAKDPNNKNSTKFVVTFKELIDAVKRHIRLFYGFHDILSTTSDENTHVDNVQKKITKLEAMFNAISKKILNHQLEKKNFIATAKAIVQFVNDLRMSIMIIEQNRAMFVNRYVLRSVEFAESGMLEDIKTHQDEMKKKNTTIEEYDKMKPEDKKKLNIRILITESKQAPKPTPSKGSSDSSSSPSKSGQQQNTGKKSTDAKKASTDKDTTTDTATTGTDEKTSTPWYKNKWVWIFVIGAVVLAAVGVLAAILFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXF2</accession>
    <name>L7JXF2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1621"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXF2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="980" mass="112574" checksum="6D0DE5B704ED347C" modified="2013-03-06" version="1">MLPNLCSYVETTVRYILWFKATGSELERSYAVFDDINDTTIQKYLEQYDADEVPPTVLAQQRIFELRHKLYDSHNNGTDVYNPISMFYYNRSSGIRHVKNKQLSSLIRVTNCVTMKIIYLPFTKPFFLKIMLVVTKNGIPDFTEEEILLILRFFAYTSRKDLFAYAICRYLYRYINFFNCVLKYNRDARSHADTSVVTFKSFVFPPSDSEENFTEVVRSNLALKLISEGVHSASITGGKDSANLTTLNISFREISLCSLFCRLSMNFNFLETNIDHFNTSYRENLLDSITSLEIFDIDEVPSANLGGFFESGRDVLNYKLSIINSMCLLERVNKVTLKFYKCTSPLATITFINIKYLDCIVCECCSDNFITSIPHRIKVMIIDREPQTGARQIITIPGNAIGVSWQNCIFTENLETPKCIRFIEISRCQFGENQIKITSKRCKGIKITNTSANLVLQNIAGFCNLTLGTFRSSCFDFNVNETTRWSIKLVGARIENTVHINDNVTKVLFNKVEVIPGEKVVLHKRIQHLEISQSTGLFDLKSFIKLEKEFGIYTIIKVEKIQSSLNNNLALTLVRMGFDRTICLPNTYECIDMCDITVCDGAFISINKDCKTLKIRKCSGKIDISKVEHLDSLFIGFSSDCKIIFNMSDFLDVNKVHFHDICEDNALIIELLCKSKNIKRLKFTNHYSGEITALVEEYYDKNEVLPIDTLDQNQPDDHRSEELPISIPEKDPSDDCRNEALPIGTPDQDQPGDHLLQNQLPPISSLCDKRNEMINIILAAVFKKTSLDTLIELEITTMILNTENYCLLKKLVNLRSLKICPKKLNNEFLISLPAKLKVLDLVSSVVYPKTWELRYEELYSILYELKYQLKVLAVDVNLFFDLVFINDLLRRSLEILKIYLKPQYDMMRDFGETSKLELRELQIVCDDKSHASILKGELDQELSLFIDVVSNFINFSSLECLVFEVEGRLITIDPLNRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXH2</accession>
    <name>L7JXH2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993869">
        <property type="protein sequence ID" value="ELQ76148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0882"/>
    <dbReference type="HOGENOM" id="CLU_3368780_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXH2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="3833" checksum="19A79537C0E755E4" modified="2013-03-06" version="1">MKWFCSKDREPKADQAMVGASVLGESFKVCGGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXR3</accession>
    <name>L7JXR3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cornichon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1480"/>
    <dbReference type="HOGENOM" id="CLU_1797907_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXR3"/>
    <dbReference type="OMA" id="SHDIAYQ"/>
    <dbReference type="OrthoDB" id="10397650at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="144" mass="16975" checksum="FDA21AEFB18EEF3F" modified="2013-03-06" version="1">MYKSISNLQNMFKTIHTSLLFFLSLILTSIELHKLEALVHFEKNYKISHDIAYQFNRLVTSEAVPFIIFMILNFLRPTIILLLIVGFYEIHKVVKEQNFVNPVYLKDEVGFRKKEVCLKAILYLCLFVFYTLNIVTMMKKALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXV1</accession>
    <name>L7JXV1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993908">
        <property type="protein sequence ID" value="ELQ75881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1158"/>
    <dbReference type="HOGENOM" id="CLU_1305647_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXV1"/>
    <dbReference type="OrthoDB" id="8057007at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="211" mass="23862" checksum="CC2E67E713A65404" modified="2013-03-06" version="1">MLQHVSAQQLVSAAIPISSGLPSEDVSHWIQLFKLLVSSRGLNEEAQRLHLLCLLSGDVKNAYLLSNGDNLHIEEVLELLKRRFEGEVRARLLTEMKALSKRPRDTXXXXXXXXXXXWASFIEHYVVLARRCDVPEVLQLDWITDNVPPEVNTILATFKITSVELTVPKILEILRSDIVKKITANGPPQPDVNAVQSHSVRRRARKREKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXV5</accession>
    <name>L7JXV5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993907">
        <property type="protein sequence ID" value="ELQ75886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1150"/>
    <dbReference type="HOGENOM" id="CLU_2514228_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXV5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013402320" description="Transposable element encoded protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="10219" checksum="9E5A46BF9324C392" modified="2013-03-06" version="1">MRWLFWLFLSNMGRADRRPLYKNFLVIDGCDLIYPWEWTGLIGGLVCFDRTVVWNEYGGDWREGCCWIGEYCVIAVFYRNGKFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY56</accession>
    <name>L7JY56_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gpi-anchor transamidase</fullName>
            <ecNumber evidence="6">3.4.22.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="6"/>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY56"/>
    <dbReference type="FunCoup" id="L7JY56">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY56"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0791"/>
    <dbReference type="HOGENOM" id="CLU_089387_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY56"/>
    <dbReference type="OMA" id="DNFPYFF"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979237" evidence="5">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="271" mass="31519" checksum="6CA4B2031F9502A8" modified="2013-03-06" version="1">MLVLSVLLFLISETNTKNYAILLNASQYYKNIRHTANIHLFYRILRENGFADDEIIVFTCDDLIHDCRNSKKGHIILPDGEFTVPKFRGRSFTPLSFYNAVMGNNKKLIDMDETSNILIYMCGHGNRDFLKVHNKHFITSTELTNALCVLSRRGINKAFVIIDTCKAATLINREKLPENIVVLFTSKEDQDSISSFSSNITGQMTIDNFPYFFYKHIENRLDTDIIDFVEEMASNYPVESNLIIWPEKRWKICEFFKQTKKKMYCANLSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY89</accession>
    <name>L7JY89_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0584"/>
    <dbReference type="HOGENOM" id="CLU_1636609_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY89"/>
    <dbReference type="OMA" id="AFRTNLM"/>
    <dbReference type="OrthoDB" id="10250900at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="162" mass="19204" checksum="FC2462E20EB65CD0" modified="2013-03-06" version="1">MKSKSMKELINIREAIKRENSTFKTNLMNELNIITHNKKKEIKALLQRKQKRLTNTKKEITALLNDFNAKAIIADLNSKIEKFNVVITKRQKELEKQIAKIRKIKSTCFTEIERYLEELKGVQNENIRAIDKQATHVQKNLERFTREKDNASDRLFYNVTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYB3</accession>
    <name>L7JYB3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 6">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 6"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYB3"/>
    <dbReference type="FunCoup" id="L7JYB3">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1389"/>
    <dbReference type="HOGENOM" id="CLU_022882_0_1_1"/>
    <dbReference type="InParanoid" id="L7JYB3"/>
    <dbReference type="OMA" id="CPAMESE"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979239" description="Glycylpeptide N-tetradecanoyltransferase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="65"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="378" mass="43762" checksum="D4B499C560025531" modified="2013-03-06" version="1" fragment="single">VHQLTSILLLLLVVIYHRLTAVKFLPMTKEHKFWETQPVAIDASNTNITPLKGVRKTPLDLPFGLRFECAQPSEYRDIYAFLRDNYVEDDVGSFRLTYSYEFLCWEFGGKRTCPDYCVLVKDDHTIIGFVFAKEHDVVINGTKHVLASVNYLCIHKTFRNKNLAPLMITEIQRRVNMRGIACAIFTGALKLPFSICRAQYWHKILDCEYLASCKYINYFVGYKRLTSRRCRRARASDLAEIRRLNNELHTYALYEEFCTEMLACNERIMQFYVIEHDGVLQAFGSFYFLSSLAVKNEKEIKGAYLMHLVGPAKQELLAEMIDVACEQGAHVFNALAIANREGMFEDLKFLRGTGWLNYYFFNYSTLPMTSGEVSMVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYG5</accession>
    <name>L7JYG5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYG5"/>
    <dbReference type="FunCoup" id="L7JYG5">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0926"/>
    <dbReference type="HOGENOM" id="CLU_072439_6_1_1"/>
    <dbReference type="InParanoid" id="L7JYG5"/>
    <dbReference type="OMA" id="IYASHND"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044391">
        <property type="term" value="C:ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000018">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="159" mass="17241" checksum="B6B8BF91F20298C3" modified="2013-03-06" version="1">MSELVEQQPQAENSLLNNLEEVKLEEEEQPKKAYKFALVHIKATKNDTIIHATDLTGSETIAKSSGGMKVKAHRDESSAYAAMLCAQDIVAKLKERGYDAIHIKIRARGGSGSKVHGPGGQGAVRSLIRGGLRLGRIEDVTPIACGSVRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYH2</accession>
    <name>L7JYH2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1243"/>
    <dbReference type="HOGENOM" id="CLU_3015871_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYH2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6482" checksum="A909378196891CEC" modified="2013-03-06" version="1">MLQHRSIYLCDEIMEVGSGPTYLLPISSTFTAERIYSSPRTCEHKRMEKCGKDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYH5</accession>
    <name>L7JYH5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0511"/>
    <dbReference type="HOGENOM" id="CLU_2677957_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYH5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="75" mass="8372" checksum="2583201DF7841A1C" modified="2013-03-06" version="1" fragment="single">VGWLWGVCLEGVDLRRKIDFGERIDFGERINFRGVALGGRLIWEKGSILRVDFNERINSRGGLALNLNGLALGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYI9</accession>
    <name>L7JYI9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0907"/>
    <dbReference type="HOGENOM" id="CLU_202897_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYI9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="70" mass="8197" checksum="450BACEAC8673BD0" modified="2013-03-06" version="1">MKSSLLEQDVTVVFYRANKDKLMKESKYNDKILEEIKDIYRLTIYKMVSGIVRITLPPIIPEIDQGIYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYM0</accession>
    <name>L7JYM0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYM0"/>
    <dbReference type="FunCoup" id="L7JYM0">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0597"/>
    <dbReference type="HOGENOM" id="CLU_058591_2_1_1"/>
    <dbReference type="InParanoid" id="L7JYM0"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS3 C-terminal" evidence="5">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="214" mass="24248" checksum="EB99D9DB43B4B746" modified="2013-03-06" version="1">MLNQETEQIRSQSIATGIAYAELNEFFGKELMESGYSSMKFLAHEVPLKIIIRVLKTDDLINENRYRLKQITSLVKKRLKKDVTILVEMVKDKGLCPNVQAEYIRKKMSEGLAYRRAVNGALRTIKEAGAQGCIIVVSGKLKGQRARSQKMMWQTNIYSGSPKEEYMRGGKSTVHLKQGVIGIIVKIMLPHDPEGIRGPRREMVDKIRVLDVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYQ2</accession>
    <name>L7JYQ2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JH993836">
        <property type="protein sequence ID" value="ELQ76564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYQ2"/>
    <dbReference type="FunCoup" id="L7JYQ2">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0443"/>
    <dbReference type="HOGENOM" id="CLU_041825_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYQ2"/>
    <dbReference type="OMA" id="CMLGGYK"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978901" description="Phosphotransferase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="218"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="419" mass="48051" checksum="C67697540E226878" modified="2013-03-06" version="1">MYISLWLIYFFEFVWCQGTDVFEYSQRDLEAIADDVAKWIKEAKSSGSESMCLRTFVSRNSNILEATSHREMLAIDFGGTSLKLGLYKIEANQAKTTKEVKKIPIPKIETEEDRKNNGNMYEWIYNRIDEYLGDNYDVKLAGLTFSYPLRQESINSGKILSLHKNFPFEWLSSDATDPVASLNKIFEQKGRKIVIKALANDTTATLMSLPLEDNSFSIGIVLGTGTNGAYFTSNQLNGSEAINTEWASFDSKSLKKTKYDELIQDELIKKKQQWKCLDCMLGGYKFLEILNKSSKDVLGKNTEYTLEFVKEIIRKENKESPEWKHVYQVKNRAAKIISALVFGILKSENVNAKNNISLILNGTILEQDFDRKLLKEQINEMKEYFNDGLYKDTSFNFYVPEEASLVGIIRILTIARDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYR6</accession>
    <name>L7JYR6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Ankyrin repeat-containing domain, Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYR6"/>
    <dbReference type="STRING" id="72359.L7JYR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0858"/>
    <dbReference type="HOGENOM" id="CLU_049065_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYR6"/>
    <dbReference type="OMA" id="CIRNDFR"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="466" mass="54284" checksum="10BEF9798D6D7F3F" modified="2013-03-06" version="1">MRRFPQTLASINATRRISFQKFLQTDTSYKTQRTIIIQLNSLHNFLVKNGIVAKQKPRPISTSIPPFEQMYQLHLQKLALLDRSKKIYNLVYHSSLHNQMTKILLLALFSNNDAVVQKIVDSGYPPEIIKRCIPLYHYFCATGNKTLMSNVPYKASSFFGLSASIISSFKGKIALDHIDFAFMTLKQYLLFNEFRGINTIDKKVNKFLSGYCGYSSESSVNSSNTETSSHDSDESFIHSQLQFERIRDDIDHKVLFPLDFLCIRNDFRAVEELLKHTPDFAMLSKFCFLLQSHAGITLKLLQYRADPNQSFRGYTPLHVAARIGNLDVAAIFIALNADLDAKDYFNRTPMYYAKLYKHERLVDFFNQSRNKRILPYVSTDFKFINFEVFESEPCRERLRLTKEHLKRAMEKQLQKRRFMIVSLFSLTAAIKTVQTDIKKLEDWKSERVCYTALNSYEKFKSIIIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYU8</accession>
    <name>L7JYU8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="15">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">THOM_0357</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYU8"/>
    <dbReference type="FunCoup" id="L7JYU8">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0357"/>
    <dbReference type="HOGENOM" id="CLU_006515_2_1_1"/>
    <dbReference type="InParanoid" id="L7JYU8"/>
    <dbReference type="OMA" id="INCENTS"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="26"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ELQ76638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="773" mass="88797" checksum="4B2ECD062012D9BC" modified="2013-03-06" version="1">MVYDCLPNTRNTREQRGTKSTCYFYPHPMRSLNVTLYDSQKDFIQKAQQTIENNQTAIFSSPTGTGKTLSLLLSVVPYIEKNVVHDFSGVSAANKALINELNFNNTPIYYCSRTHSQLNQAVNELKRLKVACNAVVLGSRMLYCKQPSVNALDNLEMMNERCRELREKDKCEYFINLNGEFDIIRSEFDDHVLSHNNERIAKVEDNHVKYSTFCKKEAEPRKREDDSTSKRSFSQNIAEHSANKARSGKGFGSVAEDLRDVVGKNIGNNVNLYKTVTSLSTSSFKNDGIYDIEDLKNSNCNFCPYYKSKQLSKSASITFLPYQMLFSKDARDSFKLPISNSIIIIDEAHNIYESVIQMNSASVNYHLLKKYIKAFSVYRARFSQTYEVNHFSSGENRNANSFNYKKTIADAFLDILGLLDDFCENNKKYALTEEKCLRVNEFLIKSHLENYNMFKLKEYIRTTNLTQKLEGYEKDLHFGLFTIVNFLVLLTNSDSNGLVLYDANKIRFTPLDPKLYFEDILECKALILAGGTMEPLNNLLSIFENVNVFSYGSICKNFVAYLLTDGPSGKKLRLTFEHRGNEETLNELFNTISNLVNNARSAMLKRNTHGGIVCFLPSKNFLKIVRERFDSKRNSDVSYIFDNLEQFTKECSVKTTVLFAVMGGRLSEGINYSDHFCRLLIIVGIPFPSLNVELRERIKFHGQDYTTVIALKTVNQALGRALRHKNDHSGIVLIDERYGKLQHLLSPWIREKIKKVGFRELFKELHFFLRTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYV4</accession>
    <name>L7JYV4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Armadillo-type fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYV4"/>
    <dbReference type="STRING" id="72359.L7JYV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0362"/>
    <dbReference type="HOGENOM" id="CLU_825296_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYV4"/>
    <dbReference type="OMA" id="TIWIDMI"/>
    <dbReference type="OrthoDB" id="2189586at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="337" mass="40055" checksum="9B870299C1112186" modified="2013-03-06" version="1" fragment="single">VQTAKRISFDLKPDSLFCAYELSTFSIKNRDFFQKLLSKNVVGLILHKIEHFVFDEELLGAFKLFKLFSQRIKFLQIETQNCPILEVCLLSLERDHKCEEINREVLCILSNILLNYNNYRKIFIDNDGFNVIKKKVYMFDEEVLSLCRNFLYSSTFQEKEAFIREIPVKYVHSVFKTQKLNNLDKIFNILRNLFCCNENELVKLLKHFDIEGFPSKLVYILMQYYDFFISCEFVYKEIILNIIYTLVNLCILPNKEKSCILDLEFAKAINMNDREINLALIWLFINITWNVTEDELVQKIREKNLTIWIDMIEEADEVIREKKGTLFDNLAKLSSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYW0</accession>
    <name>L7JYW0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993900">
        <property type="protein sequence ID" value="ELQ75942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1092"/>
    <dbReference type="HOGENOM" id="CLU_1644905_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYW0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="18178" checksum="1FB07649E3F19767" modified="2013-03-06" version="1">MGRSSKQVYIDTVMNILIERIFNFRAQNRITGQKLVGFKSSEVNARIPKEFVALGCFSVDYEAIDSQLVLNIPNGVDKLEILGSIKMETNPSLIYPIGQIEVIKSLSRKGNPEDLSISGQYFKNMVDYGYFPRNVDSLTILYFPLTCCDTRGGPERLRLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ68</accession>
    <name>L7JZ68_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0336"/>
    <dbReference type="HOGENOM" id="CLU_3175704_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ68"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="47" mass="5679" checksum="E1BBCE6FADFA8286" modified="2013-03-06" version="1">MIYECILNETLIDRKNDITKQKNNEHPQIQKLLALILIHTKYEQKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ87</accession>
    <name>L7JZ87_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative SMAD/FHA domain, Forkhead-associated (FHA) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993826">
        <property type="protein sequence ID" value="ELQ76729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ87"/>
    <dbReference type="STRING" id="72359.L7JZ87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0283"/>
    <dbReference type="HOGENOM" id="CLU_462456_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ87"/>
    <dbReference type="OMA" id="GRSLKCD"/>
    <dbReference type="OrthoDB" id="2192720at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="590" mass="66826" checksum="8ACCE76CCAE07FA2" modified="2013-03-06" version="1">MQTHCTPQYSIKILNSNTTLKTIHTKFTVGRSLKCDLRVQLPSVEDKHLVIYLDDRKYVVSGDDVMVNGAVVSGEGVFVYGDVFDVRGTRFVVMEDEDRKDMVRADGREMGVKREESVGEKELVGVTEMRNDVVNMDNNTENDILNEEPLITAAQRGDVAKTFNSQVEQRNDAYGTGDVQPVKEEPTIEIPRMHQEVPKVMPNVELTNDTQEEEEEGLSTNYENEKTTVIEEKIPAGELVIEEEMVHKEIVRETVSIDTFTKGRIAEDIAGNLKEEMRNDLKVGFVDEIREELKDEVKDVIGSDGVRKLLVNDVMERMGEEIKEKIVGENVDKEFGENSDAERNMEKEKVMEINGTKEPEIKDEMDQETAERNVAQEVGDRKESTIDQVENQEHDEVVVTETEQTKNEDLKEKEEVSEHKAQNVAITGTNDVKGEVSDKKPEKEPVKRVRKAKAVTKEVEHEEKDVKSEDVKKEAESGEKGPRNRVIKKEVEHEGKGTNKGDTKKTRGAKVEKDVEEEKAEDMNKEEPVKETKTSRKVKADATPKRVKKDVVEPETKKKGRRPSVPKKAAAETKRKGSVSKTAAGRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZC5</accession>
    <name>L7JZC5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0197"/>
    <dbReference type="HOGENOM" id="CLU_3371050_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZC5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="4153" checksum="292C0143120DA957" modified="2013-03-06" version="1" fragment="single">VQLNDMICDVDAKIRAEFEDLKSFTTDTEIIFFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZG2</accession>
    <name>L7JZG2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent DNA ligase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZG2"/>
    <dbReference type="STRING" id="72359.L7JZG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0406"/>
    <dbReference type="HOGENOM" id="CLU_940684_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZG2"/>
    <dbReference type="OMA" id="RIVINHT"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase ATP-dependent N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="8">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="296" mass="34151" checksum="D7C3E13E2E122A4F" modified="2013-03-06" version="1">MPTLFKDLCSVFKEIEEKSGRLEIQQILSNYLSTLDKENMIIAFYLCTGTVYPTYENKELNIGEGILYKVIGDMTGKNIKVLKKEYAEYGDLGQIACKYKINKLIKVEKSFELNEIYNGLKKIGEIEGKDAMFRKKNAILKMLSVMSPNEIKYFVRLLEGKLKIGLAIQTVLISIGMVFENKEDSLDLLKKAYDRCASVEILLDKIYKDGIQSLDLLEIVPLIPFRAMLCNPLNSFTVNFSDFICEVKYDGERIQIHKKNDQVKFYSRNGEDSTFKYPDLVAVIRKEKTILFWMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZG8</accession>
    <name>L7JZG8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-directed DNA polymerase, LTR Retrotransposon</fullName>
            <ecNumber evidence="8">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="8"/>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZG8"/>
    <dbReference type="STRING" id="72359.L7JZG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0145"/>
    <dbReference type="HOGENOM" id="CLU_000384_23_4_1"/>
    <dbReference type="InParanoid" id="L7JZG8"/>
    <dbReference type="OrthoDB" id="2193209at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="13042" checksum="1EA97011F089C628" modified="2013-03-06" version="1" fragment="single">VQWASKKLTPTEMRCRISEKEMLAVKWGIEKFSYELKARKFHLITDHKALEFIRNKPEFYNNILNRWCEAIQQYEFTIEYSKPVNLIKADALSRIHEKVKEPTKVNKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZK8</accession>
    <name>L7JZK8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0266</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993821">
        <property type="protein sequence ID" value="ELQ76740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZK8"/>
    <dbReference type="FunCoup" id="L7JZK8">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0266"/>
    <dbReference type="HOGENOM" id="CLU_040936_1_0_1"/>
    <dbReference type="InParanoid" id="L7JZK8"/>
    <dbReference type="OMA" id="PPGIWLF"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="23211" checksum="6B0A60A71012A87F" modified="2013-03-06" version="1">MQSVKNYELILREVPTEELILNNERRVNMFKGEDAYEYLKKKNLDEKVINDLFNTLIEEEIIVRGLVSKNNKDVTISLTKKFNKRDSYIWVVEPTNHMHLILSVVLIAFVLILVMYQVWPSRIRSKMTYVFYPIFAFFIFLGILAVLRLIVFAITFFSHPPGIWLFPNLFADVGFVDSFLPVWSYHGKETKPKKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZM9</accession>
    <name>L7JZM9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993805">
        <property type="protein sequence ID" value="ELQ76923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0077"/>
    <dbReference type="HOGENOM" id="CLU_2122789_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZM9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="114" mass="13135" checksum="8D969FFAAF799B82" modified="2013-03-06" version="1">MNDELLSVLNLCSLGQLEYLSIFIGKGEKTIDSAELFIGIINRSKLKHLIMTYSIAKWRDNRKIDMSNIFRLEFNTLVILEIKASGYNLTSGNFENELNVRKIRSLKSPMLEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZQ6</accession>
    <name>L7JZQ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZQ6"/>
    <dbReference type="STRING" id="72359.L7JZQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0046"/>
    <dbReference type="HOGENOM" id="CLU_1084007_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZQ6"/>
    <dbReference type="OMA" id="NCMFSHE"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="257" mass="30076" checksum="751CF7D79353C8DA" modified="2013-03-06" version="1" fragment="single">VGIILQFVSFYYFKNVSKQRTLMIRRMLVPTKLCKALLRFRTAILTDSDLKDELKDVSEAKNDTMNNKQDYGKTEEDELEEGEVYIKRKRVVSESYQGEKRLKYVNCDVIIDKTARSEDDLDDEAEKKTMLCDKKYFLYDSSDNDSDTEPKNITKPIKNSVNVSRQPIQTPQRRTDSTKQSNYRSQICRFFLTHSCTKGDACSYSHDIKRLPCKAFHMKKNCSRKNCMFSHEPISVAELNRMAESEKWENNDFVSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZR4</accession>
    <name>L7JZR4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0783"/>
    <dbReference type="HOGENOM" id="CLU_685500_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZR4"/>
    <dbReference type="OMA" id="DHIPPHN"/>
    <dbReference type="OrthoDB" id="2193787at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="400" mass="46615" checksum="8C0E60D98B9D491D" modified="2013-03-06" version="1">MDDFIFVGPPTRKEILLYLKDKKYSLVNNPSLKYQIIFRHKMEGRSFFDVMNFNFVKKCKFDNFYIKKMFLFNDQMTGENIYRLLPFKNTEKNKSIINLYCRKEPKGDEKGKDCKMKDSGELIVEKRGNDGAVIEYGDCDDENTQILIAGRQINAHKNIQAEENPTADKLLKEMDNSIEKLNIQDGRTRLGYSTTTIEKRVRFDLEKNEVLVYGKREGNASPQNETARGRRVLGEITNRESCRDNAQIPKDKLLLQSDHAVEMPKKSRNTRSKRHTSRKSKDGIDLRKLTEKNTLLNSGYKTVIVKHSKRVNFLSHSDTTTKRDPVTKRKTKILVKFEQKDHIPPHNVNGIKPVLAKSPKLKKFKYPKGKKVVELKRTISVDFSPSNFEFERKNKKMRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZR9</accession>
    <name>L7JZR9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993839">
        <property type="protein sequence ID" value="ELQ76541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0469"/>
    <dbReference type="HOGENOM" id="CLU_1603906_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZR9"/>
    <dbReference type="OrthoDB" id="10483264at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="166" mass="19252" checksum="D119F75EE2CB582D" modified="2013-03-06" version="1">MNDRMDGKISSNSNPNTTITYIPNTNIIITIPTTPSIPNLSKWLHTGTPPHCPWLYPSLNIHSYTLLNIFDPYYHPLVMLYISTFIYLLLTSRHTLYVLISFVGYNELEYVMVCPEVVPVLIVRRWILGGYWSGRGYAMWAVGWCECVLFVGMCIVKYLKRNRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZU6</accession>
    <name>L7JZU6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZU6"/>
    <dbReference type="STRING" id="72359.L7JZU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0773"/>
    <dbReference type="HOGENOM" id="CLU_407209_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZU6"/>
    <dbReference type="OMA" id="HPHTTFS"/>
    <dbReference type="OrthoDB" id="10528379at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="675" mass="75517" checksum="56C961506F908F4F" modified="2013-03-06" version="1">MYVLYHLVAFAAAEMIKIIPVCDAECQKNMLLAKYYPAPNMPNEAAYCIRGVDVRTNKKCVVGVRGVVAKPADVKHGGVSVNPPPEDVIVSTYYKTVTVTSPTAASVATVLPNVKPSQIVYHSKNVTNSIPAAKIVPEKAPPVAGNVVVAPSVHVPAPIPAIKNPPVEVMPPKTAVAKPTVTVTQPPLIINRPVVQTVTVSQPPIVVNKPIMQTVTVSPPPTTVNYIHTVTISSPPTIVSAVQTVTVSSPPATVNAVQTVTVTVATSPQSAQTVTKEIRIESKPGAMTAIVKQPDNKKPPIEISTPISSTVSIKKPDIAPTSKNEPVPVYPAYPQDYSNYYAYYGYGDPRAYYPYDRQYGYYGNYYPPAYSYPGSTMKISKESKKLDDDKTVSKYKIVKNVDPAQAKQIMENEKKNCSDQDKNGMHNGGKEEKDCEAENVYELEPDAEKNEDDDSKPSYAPKEYPEDWGSDENAKDDKNPEKTHKKRRGRKHGKKGHRNKDKARKPTDNHKRHSKHSEPSVNAQNLYEKEDSKYTTDFQDEYNDSLPREIRERQPHVNEPPNINKYLYDRIYKKMRNKNMPRRINFDDEKNREEKLKDKYNSIIYLDEQDKMLRNKIFKQFIGERGLNQSKPVRRNGDEIELSDSFSAVVPEKKVKGDDENSSSDEIVFLSELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZY7</accession>
    <name>L7JZY7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0081"/>
    <dbReference type="HOGENOM" id="CLU_1732773_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZY7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="151" mass="17613" checksum="949E6C60F1A5550C" modified="2013-03-06" version="1">MRSMISQVDYDQISRIIQDAVVDGHGIKKDNNILANIRALHDRHQIFEELYAQKIYKHDDVMFTSLAEAIIYVCLDMCIIIDLMNDFLSQQSERFELFKDKCEINSSEFREILVNVDTQIMKACQINDGSTCTKQIEEIAMMKDDLIERIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K014</accession>
    <name>L7K014_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K014"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0069"/>
    <dbReference type="HOGENOM" id="CLU_1428924_0_0_1"/>
    <dbReference type="InParanoid" id="L7K014"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="190" mass="22751" checksum="45C4AFA108201FFF" modified="2013-03-06" version="1">MDENEGRYFDINTDVEKLINLLNKNSQIPWDDNDKYSLSHFIHLLMTTIKDRKLVSNYFLYKYDPEYMKKIQGVQNYGKIPAKVEKNKGHVKHATRRFSEQECLPLQKIYVYCTAKRQHLSNFWKFMKVHNKEYILKSIVCRSKSNDPQYFVVDSYQNKFYIIGQCYSKETNLTEIFAENDVLVALYEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7K032</accession>
    <name>L7K032_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K032"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0594"/>
    <dbReference type="HOGENOM" id="CLU_088000_0_0_1"/>
    <dbReference type="InParanoid" id="L7K032"/>
    <dbReference type="OMA" id="PLRCIQI"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="247" mass="29194" checksum="EA253E218490DF6E" modified="2013-03-06" version="1" fragment="single">VLLNPQQTFWSNSGCPSMDIKTAITQIIRKEFVPQAHVTFPEVPLSAEPSILLAIPFIKGVQTRKREYFQNYADEIKYYGLVDDYRFETRDDKIKIRELKQHFLRKEIQFEDEEWIVELLRYFYILAVEEMKYLEVEQRLNAYGAVHGSGRGIELEGGSGTSRVQPLRCIQIDGDERKELLVNRIKPTLTLEEYSERILKRMQENTTKEYEKEVMSELEAYDKEIEELVKMDEFKDEMVKGNTYRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7K039</accession>
    <name>L7K039_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K039"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0007"/>
    <dbReference type="HOGENOM" id="CLU_413431_0_0_1"/>
    <dbReference type="InParanoid" id="L7K039"/>
    <dbReference type="OMA" id="QYWHRSP"/>
    <dbReference type="OrthoDB" id="2190823at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="658" mass="75624" checksum="EE84647DF8A07A95" modified="2013-03-06" version="1">MLILKDGLLYFSKHQMLLTYNLDFTTATKNENELSELEKVRNELYGDEKYLVKIDEYEYPSSITALISYKNRLVVGTAAGKLFFDRKQVLSVDASISALFFNDPFLIIATSAGLIQIYNNKRICFQYWHRSPINQIAFTNLIYLHDGNNRLVVIDPVLSLSGSKPCLGDSDTSNDEALTDKTRRTASGQKKNEELFDNLNMPFHFHNKYLFISDDNILYAKTVNNFSSLLKLEEKVVDFTFSTNGGILFLLEESKIKIVDFCEQEVIREIRIYRCDAGRILYHNNSLLYGKDKLNVVKDVLDSVEQAKKMKEIILQENRFYVHRKVENVCSSSEDEELKDLFAQRKGRESEKLNESVDYEPSADGEYDEQHGVSTAEISKQAEAVREDVVWTPGRVQENDIILLCYNETGFLLCKQDVSVNLIELVFHDHMISNKIIHCKLKNDKGCFDANGVLLSTTTTLTYYEDTKKWELDISTVVGFKGKKIKFLGISGYLYVVVENTTYDSLVVLCKEGRIRDVYDIPRASTFVVKHGVILVLSKNQLFVYSDGQVKAIELIGAINFLGIDAQRQIYYANAEYIYRLENSMSKRVLKYTNKTVLCYYDNMFIVLNKLFPVPDVEYLRVEEKSNDEIRQEPETTNSNCTGEPWSISKCAKTYQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7K069</accession>
    <name>L7K069_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SNARE protein Syntaxin 18/UFE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K069"/>
    <dbReference type="STRING" id="72359.L7K069"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0504"/>
    <dbReference type="HOGENOM" id="CLU_101897_0_0_1"/>
    <dbReference type="InParanoid" id="L7K069"/>
    <dbReference type="OMA" id="RRALFIW"/>
    <dbReference type="OrthoDB" id="2189922at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="242" mass="28785" checksum="A84419C4489A345C" modified="2013-03-06" version="1">MNRTGEYVNFIRTSAYDGSSAKNRKEENVHAQQEGNQKNFYDCVYQKIQDFNTNVATYTSLLKKEQEFNKLQRETVDLFKVIDLESNNDLKMHFEGIKKIIMTKLADKSADIQAKKRRFINKNIHLEPEKPFVYLNAHHDKNLEMENKMIMKETHSLDYQMKQTRKSLQEIKHIQDQISLNLNVQNESIDQIFNKSKSINENVKGGNKYLKMGKEKKRLLRRALFIWLLCISFILVFLHWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7K079</accession>
    <name>L7K079_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993815">
        <property type="protein sequence ID" value="ELQ76766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K079"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0237"/>
    <dbReference type="HOGENOM" id="CLU_3260841_0_0_1"/>
    <dbReference type="InParanoid" id="L7K079"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4765" checksum="9405A2CA0EB24912" modified="2013-03-06" version="1">MMRTHVSTSCQQLYPRALSTTKMSALQTERPTYKTYNVQGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7K099</accession>
    <name>L7K099_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative High mobility group, HMG1/HMG2, High mobility group, superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993839">
        <property type="protein sequence ID" value="ELQ76542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K099"/>
    <dbReference type="STRING" id="72359.L7K099"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0470"/>
    <dbReference type="HOGENOM" id="CLU_124554_1_0_1"/>
    <dbReference type="InParanoid" id="L7K099"/>
    <dbReference type="OMA" id="QDCEAIG"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18731" checksum="C3794B4CE035C6D9" modified="2013-03-06" version="1">MPKKSRQRLAHAPKKPASSYLSFCSHLRKTDEALKSMAPSDQRQHFATKWRTLSDTDRKGYEDDYQQRLQAYREEYKKYKASDLYKQDCEAIGKESKKKRPKSAYNVFVAEEYKKVEGSSFGEHTAELSRRWKSMNEEEKMVFRRKAEELRKENMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0D2</accession>
    <name>L7K0D2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0D2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0113"/>
    <dbReference type="HOGENOM" id="CLU_1772627_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0D2"/>
    <dbReference type="OMA" id="HSTIICI"/>
    <dbReference type="OrthoDB" id="10332116at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="147" mass="16522" checksum="C3872BB3016116E6" modified="2013-03-06" version="1" fragment="single">VYLSRRKKHNTMDYCTLICIYMLSILALSWPFSSGDDPLAPEIAAAKEPDSILSDALANESVKDAIARKAAATESVKKAAREQAMAEELAKPNLKPTHEEKSFASWLRGGKQDIMPTLLERESMKTNNPITFNYLVKPKQMLELMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0D9</accession>
    <name>L7K0D9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0D9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0350"/>
    <dbReference type="HOGENOM" id="CLU_004199_1_0_1"/>
    <dbReference type="InParanoid" id="L7K0D9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="758" mass="86571" checksum="06AC73EF94A75213" modified="2013-03-06" version="1">MSCYMFDRIFRFVGSRKNNQESFAIFIRSLSFDKLVIEMNVDTAKFFRVKIAELLLINSQQCNNLIFDQFKGVISIPNVTSLNQLELSDLKELNISSKVIVITRKDGDMDITPIHEDKTLTLPILYSNIHIPTIQHNYCEDIYVSECKFPINIAGILTNITTNESVIQISPEEEFYLTSSCSEVPSKLELVNKRICDIFMIQKNVNFLSLAKITANEGSALRLNNCLESVRVCSSEINIDASNAKNLKAITLTNATSITYNPTIHLLLSYLNISTMNMNHNFDLAPSVRAFLLTNCTITSDFSIRINESISLLSISEFEGLIDMTGVAGLRKMELNRHNTLYFDRCTGTSQGCLLQIENYTFKHSVVFSDDLETIRLKRVETAQGIELVLGRGCKHLELDSPKVAINPSCSMSLEKVTLKNTAFHDIKNLLTALSRVKTLILENVDIEDYFELPGHIHAVILREIRLATSSRFSINRGCNEVRFYHCSGMYDLSKVENLEAFGLIFGLNDESTFKISFPSLDNIRELDIACNLSEEYLKYCLTKCINLQNLTVRSFDHTKKSASYPSLSISKDEVFNSLGNNLWLSQKLSKYELSREHSNNESADLLNFKTNIFICEIFTFNIRNKLKYLNLVGCGLNEENLKTLKKLVCLQTLIVDCAFFSNDIIRNIPDKLTTFEIVDTNIYKHLRANLYNLDLQTMQLLRKHKRIEHMVLSRSIMEYEHIFDCLPVELESLKIKIFSENDVDFCAHKKKKLLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQV5</accession>
    <name>L7JQV5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_3223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQV5"/>
    <dbReference type="FunCoup" id="L7JQV5">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JQV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3223"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="L7JQV5"/>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002469">
        <property type="entry name" value="Cell division control protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="325"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ73848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="710" mass="79620" checksum="5ACB451B67AADC7F" modified="2013-03-06" version="1">MDNPSSAFTFDASQDMTSMHPNTPSDLPTEIISDQPEKIKLIWGTTINISETIEAFKEILDKHYQSRIRTMISLDQNSLFIDDLYDLNQMCVNYPSEIIPILRKGLNEYILEKEPSFRQTEIEIGIDAPAISLRKLCPSRIDKVVRIKGIVMRVSTVIPELIKGCYVCSSCGKSVVIEKIKNVIQEPGACDCGSFFSYSLSYERSEYLDKQVVKIQEMESEQEPMCFNVVSYVIDRVMPGDRVEICGILKAAPILNPFTKKVKNVFRGYVEMLSVKKENEEGSAIDEDLHKENVEQENSAGKKNTGTRGYFVNSGGAEPITPDRRYERMAEMIAPSVYGHHDVKKGILLMMVGGVRKNHFNCTLRGSINILLAGDPGVAKSQLLTFVNQHTKGIYTSGQGSSAVGLSASVTRDVETGQFVLESGALVLSDHGVCIIDEFDKMNNHSRGVLHEAMEQQSISIAKAGIITSLNCRCSILASCNPVNSVWDTKKSIIENVNLPATLLSRFDLIFILLDRNDKEQDERTARFIIDVYNERSAYDKNVLMECIAQSKAIIPVISREAEKEIEDRYVELRSLNNGNTITATTRQLEAIIRLSEAHARVRLSEVVEKEDVAEAVRLIKESMLMYAIDPLTGKLDIDLVMAGRSAGQRKMLEELKKRIQNVLKKRKRCKMAELATETGESERSVKEAVDELCDEEMVVLEEDVVQIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR03</accession>
    <name>L7JR03_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3244"/>
    <dbReference type="HOGENOM" id="CLU_141794_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR03"/>
    <dbReference type="OMA" id="RREFSWY"/>
    <dbReference type="OrthoDB" id="2197649at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979048" evidence="2">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="134" mass="15412" checksum="FAF0E3439279C690" modified="2013-03-06" version="1">MMYVVIFCTLLLLEIASFGISVYSSDGVQYKQVYLVHGSTILLGNMFLVEGIMLRNFNQVILYPVIYSYTLAITFLSSSTAEGLYFAFKMVHVGIFVLRGLVLCYVINRLRREFSWYSTKRLGTNERVIGKLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR94</accession>
    <name>L7JR94_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994107">
        <property type="protein sequence ID" value="ELQ73795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3297"/>
    <dbReference type="HOGENOM" id="CLU_2405527_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR94"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="93" mass="10416" checksum="0842E84335FB4231" modified="2013-03-06" version="1" fragment="single">VYSALISSCSIKINEKISEVFISESVGIIDMVGVAGLGKMKFDNECMLYFDKNASYNGEGLLHIENYTFKNDVMFSEDVKTVYLKRVKTISNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR98</accession>
    <name>L7JR98_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3279"/>
    <dbReference type="HOGENOM" id="CLU_1579614_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR98"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="169" mass="18658" checksum="34C28B28C9872200" modified="2013-03-06" version="1">MASRKTRTLIKNQSKGDNADTKEGSTEHEKDNIDAVSAKNVLQSPKGAGRDDDDVESKDGRKKGKITKVNLKKSMGKGGNEHDQAIEGDSKGEKQKDKIKSDSKSKKKGTVGETSEQNKEKKTSIGKKTSIKLRGRKKKEEVEQAXXXXXXXXXXXXXXXXXGKKKRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRB0</accession>
    <name>L7JRB0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_3114</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRB0"/>
    <dbReference type="FunCoup" id="L7JRB0">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3114"/>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="InParanoid" id="L7JRB0"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="179"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ73974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="508" mass="58763" checksum="7A2E7DF7D04DF0CF" modified="2013-03-06" version="1">MTKKESRAITEEEFYVQRSEKLSTLRKQGKEIYPHKFNVTHSVKEISEKYGELKSGDMTGQEVHIAGRLMSIRGQGRMNFLKMLSDGEQIQVIYVADSVEKKAFFSNLKRGDILGISGNVGCSNTGELSVFAHNIEVLAPCVRTLPVEYFGIKDSELIYRNRYLDLLMNEESRNRFITRTRIIQFLRRFLDERQFLEVETPMMNLIPGGAAANPFITHHNELKMDLYLRISPELYLKKLVVGGMDRVYEIGRVFRNEGIDLTHNPEFTMCEFYMAYADYNDLITMTEELLHEMVKFVKKSVKVEYHPMKRECRPEKVEIDFSRPFRRIDMLEELSAKLGMELNGENLELKEKELVEICEKNGIKIDEPRTLSRVLDKLVGHFIEPECINPTFITNHPIVMSPLAKKHRSKPGLTERFELFINGKEIVNAYTELNDPFDQRERFQKQVEEHDAGDNEAMLMDESFCVAMEYGLAPTAGWGIGLDRLTMFLTNAANIKDVLFFPAMKPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRB3</accession>
    <name>L7JRB3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994088">
        <property type="protein sequence ID" value="ELQ74013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3079"/>
    <dbReference type="HOGENOM" id="CLU_263603_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRB3"/>
    <dbReference type="OMA" id="CKRDEIM"/>
    <dbReference type="OrthoDB" id="10350408at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1280" mass="148897" checksum="5ED787C693FC7D5B" modified="2013-03-06" version="1" fragment="single">VTIKHSETQCVSSHYLYSSRFKVITLMSDFTAAQLKKVEPYLKKLGLEVEVQNFTSNVINIIKTKKKYNVVFMDVLHNIITHNQCTEYDEVIDLYYSLKPSVLIIKALSTTLYMLPFLNNEQLKKLFVFNLGICNRKHEKEVATIAQATTIQMITTIRDERTDDLRAIIELLDEKNLFNLKLLKEVVAFIDKPINLRFETDDWEYKKEVIGLIDERNKFKIDIDYFMMYYDKNEEIILSAFLGCNRRNTNGNNKVIQNVSDQNVKLNQHILKDNDEVIKLLEPCIKNITFENSPLNTLRFIFIYTVCQKYHTNTINYIEVLAEKYEKSCYDTYLISIVGNVIKSCLVNDQKKNKIDFKKFNENVSGYFANEFCNESNNERKESNNEIESTNIDETQPGEEGSAVLPSCENEKDKNEDEDADEWHVNYDSGDSEHSDQNNGGEAVTGDMHMVQNQNDDDVALINPLLHFFVKAFPKETIELVSPLQLGTSWPIVVNNLSDSHILTLFTKPIADISNFILYNNRFVKEMYFATFKNLRENDFRNILLKLELCECESVVLEYYKKNGNEDVIIDYLMKRLQSSDESLDLPSCEKNNHMEQGYNESDSIGDNNSFMLTDSNNLVLKIVYQLIKIKVFKNLDFVFECLTKSTSNSLKFKVLGIISKKEQSTRLIKSIFCIVMDRNINLALAALELIRSIELNDTTYLYSLITLINDERLDVYDTTISILFSVLNGRMVEADLVDECLGEIVNRMERICFRKEYNGFDDKNDKEKNECIADGDSSRFIDVQKTDRSDNGEKNENLPAHDEKSCVTHTTKVVDAGNIISKSLIRKDLVDSHQIYEKFLLSSYLIANTLSPRQEKSVKFTFSELTNFLYLHQNINLSDSFFVFLSELFLKCEFICEEVVDFMLEYKKISYVLFVCYLRMIREVGMNYKNRVYEKMLRLFSIFLGSDVKNAAEQSTHINTPAISQPTLPGGDTTGQLANTRQDISNDLNTEFKIAGFNVKRSEIIDLLHSLSRFRSYEILQITKSLPQDIVLPFYIDWLPDPKIIETIGDGSQFGTESLNKLIKVKMDWEEKTSILQSLKIEKDNLETFIESSTEMMIEGFESLENERAVPNITCYNPIYDENEEMKENNTLCFGISNKIPSKKCDREKEKIIINYLTRYYDTLSKHQKLDSRSLEVFYRLSKVKKNNINVSFHAYNYLFLVKPDYLCVRIKEAIEEYLIDLMKYEHLFNRCKRDEIMYILERMDRETTLLVGKSIIELLKCKDLEIIEKVYCVLKSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRB8</accession>
    <name>L7JRB8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of ABC transporter</fullName>
            <ecNumber evidence="5">3.6.3.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_3069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.3.41" evidence="5"/>
    <dbReference type="EMBL" id="JH994086">
        <property type="protein sequence ID" value="ELQ74018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRB8"/>
    <dbReference type="FunCoup" id="L7JRB8">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3069"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="InParanoid" id="L7JRB8"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="101"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="392"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="593" mass="66697" checksum="3EEA5BAEE4882951" modified="2013-03-06" version="1">MAPPAKINNFINPSMLKEYLKNLLNYPFTDNEEVQHALSAYFSHINIPLLEKDEPLPLDTPVSLHVNRSITSKKVPIADTYAVEEQTSNDMVMVDGPYTDIKIDNIDLHVDGRTLLKDGSLCLRRGLVYGLVGTNGVGKSTLLRWLKNRAFTSTYLVRQESAWTSAAPACDGTRCAAVDNAARITVKEYLKEYDECEATKMLVQFGFKELTKYVCELSGGWQKKLALLKALLSPTNLLLLDEPTNMLDLPSIDFLERALAKTNKTVLVVSHDIAFLNSTCKFIIRMKDGLRVYKGNYDEYERLAALERANAEREYEKNEDTRRRMQLFVDRFRCNAKRAGMVQSRLKTMARMDTVQLENADRQIVVRIAGGMKGEIVRAEGVDVRYGGDSHSRSTNCSCTPHNPYIFKNLNMIIKGDSKILVVGPNGAGKSTLLKTLLHSTSVSRHPSLKISYFSQHHAHNFAPTERVLPYLLTSTRQPESAVRAVLASLNLKKDYQFVSSLSGGQKTRLMLAKLSLDNPDLLLLDEPTNHLDIGSIVALRNAIREYKGAVVCVSHDLWFVNGLFTDLYVVDGGLRYFRGTVEDYKRGLWSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRY8</accession>
    <name>L7JRY8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2907"/>
    <dbReference type="HOGENOM" id="CLU_2795747_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRY8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978659" description="Transposable element encoded protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7948" checksum="A7C960912DD4A70C" modified="2013-03-06" version="1">MWPCFVWMSVGCFVERWVTVECGRMCDSCPFLMRCIGKSSRNTSIGWFIGLKGRYGIVPRRVDIMYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS92</accession>
    <name>L7JS92_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA helicase PIF1/RRM3</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS92"/>
    <dbReference type="STRING" id="72359.L7JS92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2795"/>
    <dbReference type="HOGENOM" id="CLU_001324_11_0_1"/>
    <dbReference type="InParanoid" id="L7JS92"/>
    <dbReference type="OMA" id="RYTQNIV"/>
    <dbReference type="OrthoDB" id="3353471at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8083" checksum="D5BE213277140778" modified="2013-03-06" version="1">MTIHKSQGQSFDKVGVYLHNPIFVHGQLYMALSRVRHADGLKVYIANNGDQNRADNNMVYTRNVVCNVLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSD6</accession>
    <name>L7JSD6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2878"/>
    <dbReference type="HOGENOM" id="CLU_787769_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSD6"/>
    <dbReference type="OMA" id="IGLWGPC"/>
    <dbReference type="OrthoDB" id="2189914at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="374" mass="43381" checksum="47B2EA1819118C21" modified="2013-03-06" version="1">MKILSPLSRLFLSSLNVSDSSIRFKTPLKTENVQINKMTDTSFLSHVDEGIMSFLLCSFCIYRIIMNRNGSFLRKTGISFFVLSVCSLCTYMFLLIFLSTQMAVSRQEIETIGFLDGEYLYEIGSRTVNIVQLVNVSYSLQHIFRTSALYMLIGLWMPCVSAYALKRRTKLKDHFSLLFLEDNRKHQMKKFRRIITHESIITLSIIYGFVRIPFAFFIDFYHQDKARASVFFRSIFYGFENYVCAFFLLILQIKFFSTTEFDGEDSRSTENLNILVFALLVNTFLKYTLHILSVPFAINDMSDYVLQKCECISLVIVYLVMSTLLCPLGTQVLEHEGGESITDWKDEERMEEIGYAKGTGLIEFKGKKEEMHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSF9</accession>
    <name>L7JSF9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2871"/>
    <dbReference type="HOGENOM" id="CLU_2308026_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSF9"/>
    <dbReference type="OMA" id="IICIQRK"/>
    <dbReference type="OrthoDB" id="10305192at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11823" checksum="493A5DFF45E172EB" modified="2013-03-06" version="1">MDNKTELIRKINTSIEKIFDTLIDIFTMLSTTNTQDYKELRDIICIQRKIVQVSDTVLQIYNYTVLLKYMRYEKGVKKDEHDTFDADAMFNSIVDEIMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSJ8</accession>
    <name>L7JSJ8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_2804</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSJ8"/>
    <dbReference type="FunCoup" id="L7JSJ8">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2804"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="InParanoid" id="L7JSJ8"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978804" description="Probable aspartate--tRNA ligase, cytoplasmic" evidence="13">
        <location>
            <begin position="21"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="176"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ74265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="479" mass="55332" checksum="3E87F190D887D5E7" modified="2013-03-06" version="1" fragment="single">VTFTCTCGLWFFIFNRSVQPLRMTEKVQDVLIEIDEIREQHLGNEIEVHGFVESMKNFPKFGFLTLRAGVCRLQCVFNLGGKVDEEHFTQICGVSLESYVRITGVLKKAHKPIKSCSVSKYELEVSELEVLSAAGSLPFDLKDINVYKKGVPNVSFNKRLDYRVLDLRGTMSQSIFRIIDQIMFTFRTFLRNEKFVEIKTPKLLGSASEGGANLFEVNFFKKKAYLAQSPQLYKQMAIIGNLRRVYEIGHVYRAEESNINRYLSEFIGLDLEMESTDYLKTIRMIYSMLCAIIRDVYENNRQDVENLRKYNDFEDLRFEDEPLILSHRECVDILKEHGEDIKYEDDFSRFMEKRLGTIIAETKKIDFFVVKDYPTRNRPFYTATCADPFYSKSYDFILRGEEILSGAQRINSYEQLRQSAINNGIDPVSIEGYLGAFKYGAPPHAGCGIGLERFAKALFGSSDIRCFNIFPRDPGRLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSN6</accession>
    <name>L7JSN6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2624"/>
    <dbReference type="HOGENOM" id="CLU_188586_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSN6"/>
    <dbReference type="OMA" id="KECAGRE"/>
    <dbReference type="OrthoDB" id="2191508at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="90" mass="10914" checksum="E6EEADAA444CD365" modified="2013-03-06" version="1">MIIPPPLNTKERTEFDLNDLKSIFVRCQTLGISKDINIRKRICVLKECAGREEFMKEFLDLSLFVEEKRKEMERMRESELMNCMFECYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSQ8</accession>
    <name>L7JSQ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxylase</fullName>
            <ecNumber evidence="1">3.1.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.2.6" evidence="1"/>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSQ8"/>
    <dbReference type="FunCoup" id="L7JSQ8">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2773"/>
    <dbReference type="HOGENOM" id="CLU_030571_4_5_1"/>
    <dbReference type="InParanoid" id="L7JSQ8"/>
    <dbReference type="OMA" id="VYNDEYA"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="24990" checksum="CA7A4B0E589317E3" modified="2013-03-06" version="1">MVEFMERKHKLLGVCSGISRSMMYLVYNDEYAIVFDITDINTLGRALEIDPPARFMDMMEVFNCERVFKRKLLAVFYTRNCRNYDLIRFSYEFLTKSIFFEWNLNEKTYCFEDFEVAALTIPNRDKNAFCFLIDDYFIIGNAFFYLGCRKFYKEGTINLSITLEKLRHYVRTNVICCYGHDFSKMGYKLASKYFDPSFKVQNSKISHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSZ5</accession>
    <name>L7JSZ5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LRR containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3242"/>
    <dbReference type="HOGENOM" id="CLU_701261_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSZ5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="45690" checksum="3DB3D7840B802119" modified="2013-03-06" version="1" fragment="single">VQLKYLSIIALNDDRIRTLYQFLSKIDRCKLKHLILTYTSSKERSNVADIFSLTFNSLEILEIQAYNTMLIADTSKFNHEMNMPKIRSITISYEEMGTGFVKILNGMAPLTDLHVKLQLNDEGDYRNFIKSSEMFLSHFTLKEQLKSLSFNPCIPMERLQETLKDFKSVKELAIEHFRIENHDIPNDTKASSNQSVDLPAFLPIKEIYRVNRLKYSICLYPFLTDRIPRPLNVCQIFINVRKLIITVYKAECPWLEKNKTTDQVPDIKESLIQFINDMFAKFQILVVDCRSTKWSMLVFESLYECCLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRVVFLLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT14</accession>
    <name>L7JT14_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2533"/>
    <dbReference type="HOGENOM" id="CLU_621429_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT14"/>
    <dbReference type="OMA" id="ICAFLEP"/>
    <dbReference type="OrthoDB" id="2196367at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="437" mass="50754" checksum="E4B767BAE10C8F9E" modified="2013-03-06" version="1">MTLTENTNKLDDKKMFDEFKAMQNEYHKLYLSYFSEGKRYDDVNETNIYQSSIFMIDMVLQCCLNFRECTSFYSSILKSAKTFLVAYTCELEKSFDKKKRENNVEAQNNKCIVYSKQPDIKKKINVTYNGKRAEMENIFNKFHRRNEQKVEEKVVMDNSPLSTQTEVKISAENFDESINSILQGCSAVKKAFEIGEPEIASEKQELFLQDNNFIDDADVQNEIKDTENTQFENIIVNKTNDMIDLSDDLFQSLGIDFATPGNANDTSAIPINRLSNQRNKKRYRFNTNTNQNKRKKNDHTPNNTRQQQKQQHCSLSKSFFNNLHHNKSQDNQAAVNTGSAVTNNSKNIENNASFAARINNLCVKHKISHPEYVIERTNNVYICTAEFFSQKFTSRYFKTKEEAKNDVCRLICAFLEPAKDNIGKYYEEFILGGKNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT15</accession>
    <name>L7JT15_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2487"/>
    <dbReference type="HOGENOM" id="CLU_3263273_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT15"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4566" checksum="777BE025DCEB029C" modified="2013-03-06" version="1" fragment="single">VALEGNVVGIISDVSNSFKKIQECLAKLNIKYLNANLICDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT47</accession>
    <name>L7JT47_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994063">
        <property type="protein sequence ID" value="ELQ74191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT47"/>
    <dbReference type="STRING" id="72359.L7JT47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2889"/>
    <dbReference type="HOGENOM" id="CLU_1662042_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT47"/>
    <dbReference type="OrthoDB" id="2195822at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="159" mass="18056" checksum="55E160837919715B" modified="2013-03-06" version="1">MVNLNGHDSRKGINNDDGNDDDDDDNNNNNNDDNINDDNINDDNSINSTINSIDNSTNDNDSDNSTNPATNANTSTINGTDPFDSPSYDLSRVQQSIDDGFHILTKTNPEMRFNIKRVIPACFNGYESMDEYLRDVLPNVTKMRKKYCYNEFYDISRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT99</accession>
    <name>L7JT99_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2838"/>
    <dbReference type="HOGENOM" id="CLU_3160282_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT99"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5422" checksum="0C0B8FC259B8D216" modified="2013-03-06" version="1">MLGCQELNIYENPREEEFLGVFLGGGVTQAVTCVLRSLLRLQHTFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTA0</accession>
    <name>L7JTA0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Like-Sm ribonucleoprotein (LSM)-related domain, Mechanosensitive ion channel MscS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2468"/>
    <dbReference type="HOGENOM" id="CLU_2706557_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTA0"/>
    <dbReference type="OMA" id="MPHFQKD"/>
    <dbReference type="OrthoDB" id="2187336at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="5">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="8518" checksum="B0BACF7C281538E5" modified="2013-03-06" version="1">MPHFQKDIIFSFFKTVYVLSFSPFRIGDKIRVNNKEGVVENMDMQFVVLSNKKNKIFIPTGTVYNSVLEIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTA1</accession>
    <name>L7JTA1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994093">
        <property type="protein sequence ID" value="ELQ73987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3102"/>
    <dbReference type="HOGENOM" id="CLU_734005_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTA1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="377" mass="43204" checksum="AFAF1E929F195097" modified="2013-03-06" version="1">MINFTICNAFIIKSTRFLPTIYTVHMTRVSIYPASILELNETIGEFSINNCIDPVNFDGAHYFKAIEIGVPMYKFGMPERNFHFKRIDSERTGCLSLSNLEIHETIHFGPHIAKLEFYDVTVSEMNYIIINENFKTIQIIACKGHFIIPGIFSDRESHAIYIADYICYLKITKTKKGSFDIFLDSFKFDKLVIEMNINTAEFNQVTIAESLLINSQRCKNLVLNSFMGRLFIPNIASFNELKLFNLQKLYMSYKVAFPIEQASAMQNTPMSGDQNINVLDSSTKIHIPIIKNNHFENIFVSKCSFPINIANVLRNVITNVCLFPVVSESEFYLTNHNSKKLSKLKLVNNRVCGIWQLESDVRFLSLVGITSDEDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTC9</accession>
    <name>L7JTC9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2354"/>
    <dbReference type="HOGENOM" id="CLU_1147932_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTC9"/>
    <dbReference type="OMA" id="KYEKKFM"/>
    <dbReference type="OrthoDB" id="10439457at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="241" mass="26911" checksum="69B22E1821541A16" modified="2013-03-06" version="1">MKNLLYLIILIVGVVALVAIIVFVYGYSQAKKYEKKFMEQIEENYNSIQANDSTKDIMSEVKVLLFYKDGANNGRIVVKGVSATGAFKDLKDQNMKKSEDFLKDIKDAENLMNPDDTSAGLAFDADKIPSMSKSQPALSGIGSMFKKFNVFSYNSVIKDLKARIKEIDNTKCPAVMLFIEAESIGASSYLIDDKAKGKFKENSKAKHKTFKSVEHKGKKVTNMLTHYLLKEVLSESGNTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTH3</accession>
    <name>L7JTH3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair and recombination protein RAD52/RAD22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTH3"/>
    <dbReference type="STRING" id="72359.L7JTH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2540"/>
    <dbReference type="HOGENOM" id="CLU_100405_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTH3"/>
    <dbReference type="OMA" id="NEESRRY"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="195" mass="22312" checksum="33A57D7CA1F889C5" modified="2013-03-06" version="1">MPRKQLTPSQRSFSHISKELNKKLGPEYISYRQAFNNTHIAYIEGWTAINIANRIFGYNGWSSKLKQITIDYIDECNQRYSVGVSAVVRVLLSDGAMREDVGFGSADNQRVKSQAIEKAKKEAVTDALKRALRQFGNALGNCCYDKEFLRHVRSVKRQDEQVLNECELLRRMDVGGDECMLSLESELDDLVKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTJ4</accession>
    <name>L7JTJ4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_2260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTJ4"/>
    <dbReference type="FunCoup" id="L7JTJ4">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2260"/>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="InParanoid" id="L7JTJ4"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000386">
        <property type="entry name" value="Fibrillarin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ74783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="273" mass="30790" checksum="09589F0395629961" modified="2013-03-06" version="1">MAGVTQRHKFTKYRGNESDRKPRDSKFFKKPKKFVKQTKVLVEKHARFPGVYVSRGKEDSLCTLNMVPGMSVYNEKRITVDSESEKKEYRIWNPYRSKLAAGMVSGCEDIYMGPGSKVLYLGAASGTTVSHVSDLVGPSGVVYAVEFSQRSGRDLVNLAKKRPNIIPIIDDARYPQNYRMLVPIVDCIFSDVAQPDQARIVGLNAKYFLKNRGGVVMSIKANCIDSTKKAESVFAEEVNKLRKDEIKPREQVSLEPFEKDHAMVLGIYKPKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTJ7</accession>
    <name>L7JTJ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994078">
        <property type="protein sequence ID" value="ELQ74082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3003"/>
    <dbReference type="HOGENOM" id="CLU_1295214_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTJ7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="233" mass="27547" checksum="ACB04A55268C9BF2" modified="2013-03-06" version="1">MYTKLRKADDNNCGIKEEIKLLNGIVNVLIQPIFNVRAQNTLETLGLLEFRLDESNTNILGGFVALTKNCVSYEMSDTIFLSSIPRNVRQLEILGNLNTSEYFNEGWILFNYQCIKLLSELKCIEELTVEGHFLRQTQNFQSFPPNLKHLKVSYFDYYESCYESNNIRFVLNKLTLLMYNNEESRVKWDDVERRIRIDEMLNYLSRYIELDKLEELIVEDGENEPYHYFPSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTR8</accession>
    <name>L7JTR8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2372"/>
    <dbReference type="HOGENOM" id="CLU_3227280_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTR8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5046" checksum="ABB708D3A5101B48" modified="2013-03-06" version="1" fragment="single">VLMDKYCSDIFAVGTVNGLDIKILDVTTYSCCFYHHESQCHDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTT0</accession>
    <name>L7JTT0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2387"/>
    <dbReference type="HOGENOM" id="CLU_1636610_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTT0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="162" mass="18368" checksum="3262F2F799FAF88C" modified="2013-03-06" version="1">MHIGSYQPILHTVKTFFQHSSQEMDENRENNTLINDDGINTSADEGFVEVNTRSRADDNLYSTGNVAKMDELESAKHVISEKTGANRTKSTEKIPYVTDSSDRYDRLFLELTSKIISVNDYANSKNRNETTMNEVTRFSSMCKAFNSKFSAIHGLQISPRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTT1</accession>
    <name>L7JTT1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2926</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTT1"/>
    <dbReference type="FunCoup" id="L7JTT1">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2926"/>
    <dbReference type="HOGENOM" id="CLU_057784_0_1_1"/>
    <dbReference type="InParanoid" id="L7JTT1"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045015">
        <property type="term" value="F:HDEL sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="232" mass="27580" checksum="69703E5C4DB3BE18" modified="2013-03-06" version="1">MDFGKFLYSIFRFTGDIVHLYTMLILFKKIRETKSVSGLSLKTQFLYLVVFVARYLDLFYFWFGSFLDVYNFIMKIIYISLQSVLIYMIRYKYFYSYDVFLDTFNVYNLVVPCAVLAVFLKSGTYGLVDYFVEFLYTFSVLLESVAILPQLVQLQESGEAETLTSQFIFFLGLYRLFYVVNWIVKLFFGLRVNHLLLATGVIQTLLYADFFVIYYKYVFTRKGNERLPKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTX1</accession>
    <name>L7JTX1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994013">
        <property type="protein sequence ID" value="ELQ74869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2198"/>
    <dbReference type="HOGENOM" id="CLU_3419469_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTX1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="25" mass="2725" checksum="50B812B09A05776A" modified="2013-03-06" version="1">MRYKAIHEQTVVKVTVGLSAPGKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTX7</accession>
    <name>L7JTX7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP:ADP Antiporter (AAA) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTX7"/>
    <dbReference type="STRING" id="72359.L7JTX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2894"/>
    <dbReference type="HOGENOM" id="CLU_514084_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTX7"/>
    <dbReference type="OMA" id="TMIVIFE"/>
    <dbReference type="OrthoDB" id="10378889at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="538" mass="60972" checksum="5E7E7C6C57D0444F" modified="2013-03-06" version="1">MSVPCLESSALTNSSSAVLSNNPSARNNKSFTTWKVKICAIMAFICYVIIYSSRNLLNGLILSRQGPITKLVSIALYVQPLSLISSLWIRRQLRQYTIRQLLDHALLAFAIYFSLINFILVKFRHVIDADSFYINDFLSDGKSLYKRVDLLFVALSTVTSPTITVQYTMIVIFEFVVQYVLVFSFFNDLFSQKQFNSFISILCVCDVAGSFLSSIISSLYSGLGNLIGAHMIDTMQIAFFLMVSALCFVLLYLTKEIQKSTQQECAAELDDQFKIRVDNSDESVSLTTMGVISCILRNRFIRSISFYVIFFFFINELLYASLETTICGMNGSTSEAVSSSVTRTTSIIRGVSSCVILVFLLSSLSRWLITHKWTLLVYTTPLWCFFSCITIFMLDTVRAGIEGLSLSFINRKTSFLNDADFIFFKDHLESATLVISVVVCIFLKIVKTVAFFMSKETLTMMVDRKVRSRIRPIYDGMCPLIGKSLAAITMVVCAEIMETYNARVFSIFLLVISVFVVLYWLKNARYLCLRYMNDVYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU20</accession>
    <name>L7JU20_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
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            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
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                <person name="Bernhardt J."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ELQ74546.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
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                <person name="Becher D."/>
                <person name="Bernhardt J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ELQ74571.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="63" mass="7415" checksum="EE1581E3801B17C2" modified="2013-03-06" version="1">MQKYEDADEYEKNFLKKYLTRKAEDKLNELEKRLKKRYGYKKRTNNGADGKNAPRTGALTQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU89</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
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                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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    </reference>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUA4</accession>
    <name>L7JUA4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 5B</fullName>
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        <alternativeName>
            <fullName evidence="7">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2536</name>
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    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
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                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUD4</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUH7</accession>
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    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="103"/>
            <end position="122"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="EMBL" id="ELQ74970.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="128" mass="14620" checksum="C8DA26A20E263C50" modified="2013-03-06" version="1">MSAPNSISNSFDQKDDLTLRSIKNIVKRYNKQRKVTQTDTSPTYLKLLLTSCKDELKEMSKNKKRITSMEIEKMMSLIGEISQEINDLGKICGVEKKRNTRMVYYSLFVICIIVGVVVGAIVKLQILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993994">
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2644899_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUH8"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="77" mass="8831" checksum="7A6E4B5E71CCA78B" modified="2013-03-06" version="1" fragment="single">VMKVFRNLINGLGIQFESDILEGLCALSEYEVKLRLSFENLFSHQNNGCDLSNEELNKRIETIVETLKSVNKLLIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUI8</accession>
    <name>L7JUI8_TRAHO</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993993">
        <property type="protein sequence ID" value="ELQ75089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUI8"/>
    <dbReference type="STRING" id="72359.L7JUI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1971"/>
    <dbReference type="HOGENOM" id="CLU_543136_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUI8"/>
    <dbReference type="OMA" id="PCPQPCY"/>
    <dbReference type="OrthoDB" id="10454701at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012926476" evidence="3">
        <location>
            <begin position="16"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="502" mass="56471" checksum="94490B5E97202A73" modified="2013-03-06" version="1">MQFLLATLLAGLIYGEINFQQSDINEMQPVTDIKVDYFVNGKQKSLDDSCIKVQKCKDSSYDTVISGCRSETSFASSSIIRVKFFAKTDDDPMAPASNTIYSIIYSKDISIVAPQGTTASNELEFEITKATRQFCIKLKQSVYIGVVNVGTTDDPKLEITAPMLKNNPEVEYVLDDLTPPDTVKISTSEGGVEAYKRFQWNNAKKALECCFEHARLRCTPEFRKQLGKLQQYLKCGRERKRWACKVEGCFMSTCRTPRRPGPVCYPEPCPPIPQPCYPAPQPCYPAPQPCYYPPAPQPCYYPPAPQPCYYPPALQPCYPSTSYPSECSSQTSVSIQFLVMLSDNLCRVMDICQQNPTFFAELNTITYPIAHQEYISFIDKKIRGPCNVVPYYAQPQAPIGIVCRSGTYAVDYLTGVNKDFLFACRVLCKPQPKMIAKKEPVRKTTRDRKKKKVEEESSEEEEEEETHNKKKKKLSRGVVIGISCCGGACLIVALCYVGYTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUJ3</accession>
    <name>L7JUJ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993991">
        <property type="protein sequence ID" value="ELQ75094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1968"/>
    <dbReference type="HOGENOM" id="CLU_2984814_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUJ3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="6845" checksum="E275EEDC6E1AF94F" modified="2013-03-06" version="1" fragment="single">VTDDEQLNNQCYCKFLCSADVCVWRMMMNYSLKVDVGWCVSDDVKFPTEFYGHIYVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUN7</accession>
    <name>L7JUN7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">20S proteasome, regulatory subunit beta type PSMB3/PUP3</fullName>
            <ecNumber evidence="1">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="1"/>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUN7"/>
    <dbReference type="FunCoup" id="L7JUN7">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2344"/>
    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="InParanoid" id="L7JUN7"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="205" mass="23033" checksum="D0900D7B805446C3" modified="2013-03-06" version="1">MSDISTFYGGSVLALTGKHSAIIVSDKRLGNNSITVSTQHDRVYKMSDKVYVGMTLFVPDVQMLVRKLRMEVNLFEIEENRRIDPDEFSSLLSYTLYSHRFSPRFVDPVVAGIDAHDKPYICSMDLLGCQSTSNDFCAVGTAEDKLYGLAEALYVPDMNDDELFVTAMQIFLNAVDRDALSGWGAEAHIISRDRVVKRTVKSRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUP5</accession>
    <name>L7JUP5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2020"/>
    <dbReference type="HOGENOM" id="CLU_375613_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUP5"/>
    <dbReference type="OMA" id="QQYREMD"/>
    <dbReference type="OrthoDB" id="10401936at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="855" mass="100822" checksum="53ACF1129D77EFA2" modified="2013-03-06" version="1">MDIHRKIFIAYKKSKRFSLLLEIYKTLNLRIPHCVSHVYIKDHYNNVEDSFIKLLERSTIQKYFRGMLTAYSRMILNASPPETISILSNICYILGQNLVLNEVDRSKIYRIIIELTGKFFDEDTLKVKDQANSTITESMRTVFNQLLENARVYFNDDREFLFLKYLDNLDEKSTLKLRVYLKENLENNLPLLYKVLTQGTAVFEPDMYETLISLYQNGGYKDDDTMNQLFFNNLTLKKSPNDKLKRNHSLKAQNRLVDQGFSRNKYVKLMLRQKSTQKTNYDILCNCIKFIQQRYNLCKIPELSQYSRENLLLIDENHIEKYLHENRIDILTDSKINRVAVVAKILKTDEFTNSLIFGMFDVKKIVKKHYNDLINTALQTNSSSQLKTTGRTAYTEESKIIKTYEFIENVEIGHYEVKDNKEINKNDILSTSNRKNTKDITHLNNLLLLNNIKRLSIKVNYDYKVLRRLFNVHKSVKITGVLLEGQINFDYLLLLNDVMASNILRRRSLKELFHKILYSEQTGRSLKLKYQILGMLIQQYREMDVFITDNNLYDVVENNAKKAKSLGKKNRALLEKTTYNKKIYERIDSTDINEDNAEILSVKIWDETQIFDVEETPYILKLLIACINSTKKGFLIRRIETKLEYYMSIHTCYFYGRDMNLFFVFLESILRYSLKNKKLLEKIFYFLLEYEQHMVLTVFYEHNRALFLYLCADVYQVRNYTKHKNVIWNEKHKKMLYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSLNITFIDVSLKIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUR0</accession>
    <name>L7JUR0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Ribosomal protein L24e protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUR0"/>
    <dbReference type="FunCoup" id="L7JUR0">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2300"/>
    <dbReference type="HOGENOM" id="CLU_089419_2_2_1"/>
    <dbReference type="InParanoid" id="L7JUR0"/>
    <dbReference type="OMA" id="NAGKEMT"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="168" mass="20263" checksum="12617025EDB77A7D" modified="2013-03-06" version="1">MKKIFSYPCSVYKMRIEKCSFCSSSVYPGHGLTFVRNDSMVFTFCRSKCNKAFKRKWNPRRTRWTKAYRLYNKKEEHGIAGMERKREEIERYRRSVVQDTVNAIPVINELESEKRKHYIYNRIMSVRERNKDVDMNILRKHGHLLEEGKESESKKKMEEVENVLNIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUV6</accession>
    <name>L7JUV6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-type ATPase (P-ATPase) Superfamily</fullName>
            <ecNumber evidence="11">3.6.3.1</ecNumber>
            <ecNumber evidence="11">3.6.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.1" evidence="11"/>
    <dbReference type="EC" id="3.6.3.8" evidence="11"/>
    <dbReference type="EMBL" id="JH993977">
        <property type="protein sequence ID" value="ELQ75253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUV6"/>
    <dbReference type="STRING" id="72359.L7JUV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1801"/>
    <dbReference type="HOGENOM" id="CLU_000846_3_1_1"/>
    <dbReference type="InParanoid" id="L7JUV6"/>
    <dbReference type="OMA" id="PTECFRE"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978830" evidence="9">
        <location>
            <begin position="18"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="10">
        <location>
            <begin position="443"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="668" mass="76634" checksum="28DC4E81F38622DF" modified="2013-03-06" version="1" fragment="single">KMFYIFILYFVILFASCTMLTTNLRKNEVEMYGIDNFSKQALKLTGTNYILYSYLIPLSLFVMIEVARIFQKTFVSYDPDIKGAYCRNSNVTEDIGMIDIILSDKTGTLTENKMNFRYYDTGGGIRGTDSLNINDSFFFVLNLLCNNELQLINNKYEGISQDEISIVEKLENVGCFLRNKTDVMLKIEIENAVYDVKVLAVLEFNSERQRMSTLVQISSRNERCVKNNEVYLFTKGSDQRLSAHLSQPLAIEVNSNYRSLLVVHRRIDDTDELNAFLNEYHENVLNPKLIESLFERLEVKLEFAGVAYIEDRIGFKVKDTVEDLKGAGIKIWMVTGDKKETALSCGRSVGITSNTAYKPDEIVDQLNENTSLPMDRAVWMDTLPDTLIIYRAIPDKKAMVAKELVKRGLTVLAIGDGNNDVSMINASTVGVGIRGKEGGQAALAGDFAIMSFHHLRKLLFHHGKNNLIRFSKLTINSFFKNIFLISFQFNYNFSNGFSGLSAFNYYFLNYFNILFTSFIPFTIAIFDRGKEQREFQDQTADRLLLESYKETRNYFSTKTIFCSMIFAIMKGCLLYWTSFGMLDWNYAYVTTYFSYVVFISTVIFQISLIEFFNIYTFISMAMTTLIFGIVMFGIDEVDYTIYGNPLFYFTLLAVMSINVGSDLIYKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV37</accession>
    <name>L7JV37_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1776"/>
    <dbReference type="HOGENOM" id="CLU_1673534_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV37"/>
    <dbReference type="OMA" id="QTEIHIP"/>
    <dbReference type="OrthoDB" id="2195253at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="158" mass="18306" checksum="7B11E48F8091CA9E" modified="2013-03-06" version="1" fragment="single">VNMPKSEKKEEVRDEEPKQEEVKKDEQPEEQSQKEEPAKTESAKNVEPVEEKPEEAKQTEIHIPKIKSGKMQQSGVLMQNDILTVQIDDIVEYVKNRKEMEKLKEGERLEPFIIFLNSRFISTVRHNIRMRRAKTGIIVVVLLIVVGVAFFFAGKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV48</accession>
    <name>L7JV48_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2167"/>
    <dbReference type="HOGENOM" id="CLU_2312986_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV48"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="100" mass="11777" checksum="00F973AB2D1AAE21" modified="2013-03-06" version="1" fragment="single">VQIIRLHPMDHRTVYFDYTKSIYNTPTSFRILSTPTDLCVFVSQSRGRMVFSDEIHEKMSAQRMGRGKKILVFCMLDGENMLRSVEEELYDVLVRNKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV51</accession>
    <name>L7JV51_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1796"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV51"/>
    <dbReference type="OMA" id="EYLVFNN"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="964" mass="110978" checksum="740DF661C17DBD40" modified="2013-03-06" version="1">MLAFAHSMKHYVYEYIKITIKYILVFALTQNTPVNEYLVFNNLCDTGLENFLRTCESTQIASSASRVLNMAEMSEPVADGIKGIGKAIQKHFTCYTNEIFGLEENRCESYHDFIAANINDMAFTIINVPLSMSLFKKISNLEQDTVTNFTFEEIYDMFVHLFPFRDKQGLCCLAVGLHLQNNQNLMEELKDCYIEKDKTDFDEKIRYLSACILNDKMGPENFVIMLNTNVTFRLTEDCEEVLASHHNSTFTDITQNMNFIDFSIGFILTYVYIDHNSLMIHADAVIKKLIDDDICYPLTLHIHNMYNTSSNDYNNERSYSSEIESLLYYINYVYELTNTMERRMVNLILELRGFKMKFDPSYFDSIPTHSTIECVDCSHMFLVSIPCDRIKITAKYLDSSYKTIEQICICVEEAYYTDSVFVNNLAFIGRHKRVDIRSSTINDALIFSPNSDCNYINLIAVEGIVCLSGIAGFKEMWLFKNADAGRLLYEKKGPGQSLFKLENAGVYGTISIGIDIGTVILRNIMLKPGEKIILSNANRHVEIIKAYGLFDMRAYLGVEQFVNRDVSIKIIAAQEKTSKLSQIELKNMNFESNVVLEDVFERVSLKNIKLRDNTSLRLNSSCKELVINECQGLIDLSAVGKLDKIEMTLHFQRNAIFTSKGPMHVRHLHLIQVYQTAEEIEFSLPDFVGIEHMQISSDDAYDHVKDVKRYNEQAETFFEHENLKDSPVPLSYEQKSERLSGHIKLSNYINSHWSKLVQVSAKELDLAGIVVMRENWKSLKELVNLRSLKICVENLHAELFEYLPPSIRLLELSCMITRDKNRHITVKHSPLGCTSLPNLRVLIVEADYLPLLRSLSTLLPSLSTIQVRITSVKIKHSLTTENKLKIRRLYIYDKNERERLQYLGKIMRDKKIVAFVEMLAEHIDFNALDYLGIISDRRLIVLNPITYEVLNKRLLHIPASPRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV75</accession>
    <name>L7JV75_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Synaptic vesicle protein EHS-1, EH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2113"/>
    <dbReference type="HOGENOM" id="CLU_1321724_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV75"/>
    <dbReference type="OMA" id="VINIERY"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="208" mass="24757" checksum="D8054E41548D09CB" modified="2013-03-06" version="1">MSGNNTFIPCIFEPRQMTTREFTNLHEIQSITSELRKKFSYLLSESVKKIKEVKYTRKEQKERLSHDIQMMRAEIKKNEEEINRLRSNLEKLKHTLDKERNELLEAHHENDGLSKQMAEYDENKKNLERLVNEIERRVRGLQAQKANEMRSIEANEKKLEAEADQYRKVLGINISQVCDSVLKIEFLILMRPISADILLWILKTTWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV77</accession>
    <name>L7JV77_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="16">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">DNA repair helicase RAD25</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">RNA polymerase II transcription factor B subunit SSL2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Suppressor of stem-loop mutation 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">THOM_1685</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/SSL2, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/SSL2 is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="16"/>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV77"/>
    <dbReference type="FunCoup" id="L7JV77">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1685"/>
    <dbReference type="HOGENOM" id="CLU_008213_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV77"/>
    <dbReference type="OMA" id="RCQEIDY"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="229"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="442"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ELQ75388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="666" mass="76772" checksum="B0F7AECBC28A82BD" modified="2013-03-06" version="1">MTEVFLPKQALREAPTYERIVLKENHSDYPFWVNYDGIIILETFSPLFKAATDFLIAISEPISRPKHIHEYKITSYSLYAAASVGLNTEDILFSLDRLSKNVIPKCIRKFITACTLSYGKLKLILRESKYFMEIANGDVLKTVLKDPQISSALIQQEIVADDVSEDTKSLMYEIRLEHLESLKKRCIEIDFPLIEEYDFRNDKKLKEINMELKNNIVIRTYQEISLNKMFGNGRGRSGIIVLPCGSGKTLVGITAICTIKRPTLVLCTSAVSVEQWKAQIKQFTSVKDEDIACFTSERKDVCDAVIISTYTMLCFSGKRSYEAQKAIDYIKNTEWGLLILDEVHVVPAQMFRKVLGLVSHHCKLGLTATLLREDDKIEDLNFLIGPKLYEADWQYLSMQGHIATVSCFEVWCSMTNHFYAAYLRQNMRKRRVIAIMNPTKFQTTQYLINMHEKRGDKIIVFSDNVHALKSYALKLGKPYIYGPTGQQERMKILKQFQTNPMINTLFLSKVGDTSIDLPEATCLIQISSHFGSRRQEAQRLGRILRAKRRNDPGFKVYFYSLVSKDTDEMYYSTKRQQYLIDQGYTFKVFDDMKMDNFDNRVFKTKEEQKELLASILLASENELESEDAEETVVSQKSLRSVSNVENVAYVEKKKKVTKDLFAKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV92</accession>
    <name>L7JV92_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1833"/>
    <dbReference type="HOGENOM" id="CLU_3392562_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV92"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="32" mass="3605" checksum="497B9A19F21F0BD1" modified="2013-03-06" version="1">MTTSDHIARESKVTRPRSALSAPGKFIWCVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV98</accession>
    <name>L7JV98_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exocyst complex subunit SEC6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993968">
        <property type="protein sequence ID" value="ELQ75354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV98"/>
    <dbReference type="STRING" id="72359.L7JV98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1697"/>
    <dbReference type="HOGENOM" id="CLU_025213_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV98"/>
    <dbReference type="OMA" id="LAYDSHY"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="691" mass="80427" checksum="E3F5CF2530491454" modified="2013-03-06" version="1">MSLQELAKMLKTVDDLDKKLPAIIENPDLDARESAYNKKIESITGKILDIQKNLENTQSDLGESRRLVARITRAESNFMDLISNYNQIKKLSTTFFNMKKTRRYADKIDVKEIEGDIIKWDEFRWKIMYYSADLSEEKYLMIQPLVNDIEKRYLEWEIQVLKVGENFFTLDDYGEEYFSRENVLSMIVYEEKKDVEALRAKRGRDGSNPTVEKEYFALGGTKFVIDTDVIAGNERIKSTLEYDRAFYYANKSLCARPVRKLKLRFLKNVYKAISQREIYNAIGDLKLLFKTEAFDVNNENSIFVFYHAVLKSKINLSTLEAGDILNLLAFKKSYNTLLQAHSVTMTDDILDEERFIDRYLSVLQNKIALWISNITNLEVEMLKERSKAPPLDESNLFISTNFINLLKIIKEQLEPVTFDERIFKGVSRFILDSVTDFKNAIVLTLENEYKSAISLSSTPGYEEYAIMIGNSGLKLTQYIANIPQCQNVEISELGEIFISIVKSSNHFLIKFVLATLKPAIKELFTERYYAEKNLKQITATLKDFLDDYKECMNEYVFVTFVNDLAAEFSTVYFKQLIKKKSLIYQSLCDNIENDQDVMNRLFWPYVNEDIVNLTVLNPLLVTRSVDTFIAETKNVLYTYEFKKDFIKSLIKKRSDLDANEIKELTDAVNSVYVSDDGTKKKKSMFKMFKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVA9</accession>
    <name>L7JVA9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_1616</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVA9"/>
    <dbReference type="STRING" id="72359.L7JVA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1616"/>
    <dbReference type="HOGENOM" id="CLU_814324_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVA9"/>
    <dbReference type="OMA" id="WECKRFE"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="12">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="174"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ75423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="331" mass="39603" checksum="5DDFB13EA34A8D98" modified="2013-03-06" version="1">MRRNTLTPARGRLSLAHPAQAVPEKRNVRSPSYQEQCITNVLSFLDEHNYENTSQKGVRSPTLKEFQNLFKFTISFFYKNWECKRFEDDAMQLIKQLKYPYINEINKSHLVTTSPHSWPVVLSFISWLIDMIRFVGVCEAEEDDVFVRCCFDGYLRFMEGIDNHFEDTLSEQFRKKHETKIREYESRMDRKKELENRLNEWEMKGENAALKRKIEELEDDKKSIMEGFKQLEMKKDKYCKMTQRYKEEIGELGSGMGALQDERNRLKENIGKQKINVDSYKEMNARKNELLKQLERIKPEKEKCFVMLSEKRRSWARLERRLRSTCTILDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVM5</accession>
    <name>L7JVM5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVM5"/>
    <dbReference type="FunCoup" id="L7JVM5">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2264"/>
    <dbReference type="HOGENOM" id="CLU_050888_2_1_1"/>
    <dbReference type="InParanoid" id="L7JVM5"/>
    <dbReference type="OMA" id="CPLANTK"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="234" mass="27731" checksum="EFCEDF30B60C403F" modified="2013-03-06" version="1">MTNPGRMSDESIWQLIGGKNNFCAFKLPTDTQTLCKHENNVTGICEQSSCPLSNSKYATVREIDGRLYLFVKEPERVNLPVQAYEKILLNAEYDEALKEIDEILKYWDPWTIHKCKQRLGKLTQYLIRRHELMADKDRVQYVARRKKALKIERGRGVKSMLRMDIEKEVKEELLLRLEEGLYGDELKYELERETEKENVRKRRRVFIAEFEESDDYCDSKTVKSKSKAKIKLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVM8</accession>
    <name>L7JVM8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2269"/>
    <dbReference type="HOGENOM" id="CLU_1338437_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVM8"/>
    <dbReference type="OMA" id="FEMATHH"/>
    <dbReference type="OrthoDB" id="10321857at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="24154" checksum="220D4E299545C8DC" modified="2013-03-06" version="1">MNMKLLRTYPNILARHCRQLDELKTTTFTEHDFMVLRKKQAFEMTMYHFITGLFKNKSTNSTFGYVPISKNVFENKNAPDLNLTCEIMIVKAFDILGVFQHEATTVLFKALGNLSYFYDMMVFSPVPIVVFPTDALKAVREFLSLCYDCKKATEETVLVFDVGIYELVLMEPYVALNFGLETETTEIIQSENIFSFFIGFIYQKLPSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVS5</accession>
    <name>L7JVS5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993950">
        <property type="protein sequence ID" value="ELQ75529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1513"/>
    <dbReference type="HOGENOM" id="CLU_098502_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVS5"/>
    <dbReference type="OMA" id="RMYIENT"/>
    <dbReference type="OrthoDB" id="2192887at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="225" mass="25443" checksum="0102FAAEFF815BFD" modified="2013-03-06" version="1">MSNKTFASVRLFNHLLVILQLLACISLIAIRVAFADYFSVEEVLGIGGLPMRAVLIITAFLNLIIPFFGACVIDSKLRLYMRIFLVYDSLTILINGLSLLYVYGMFMNIFEREFSKLITQNQGNRMYIENTYSCSDTSEVTCIQMFTDHLKNVQKYYIAVVGVIFGLNLVMWVLVRIALSLDLKGKRVRVPKIKKQKVGFSTGSLRNKRLVPVGNSPPESIAEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVT6</accession>
    <name>L7JVT6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2218"/>
    <dbReference type="HOGENOM" id="CLU_2470666_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVT6"/>
    <dbReference type="OrthoDB" id="10414108at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="88" mass="10468" checksum="9F8470F7D7EDD318" modified="2013-03-06" version="1">MSKCFGEYLKEVKNEIIEAKSVKRALIHTYEWIDDHVFSRFSTRFFKLVSTGCFYIYNTFIYLIVPVYYIYRTECAENVSLLAAEQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVU4</accession>
    <name>L7JVU4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVU4"/>
    <dbReference type="STRING" id="72359.L7JVU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1482"/>
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    <dbReference type="InParanoid" id="L7JVU4"/>
    <dbReference type="OMA" id="ARMQGRN"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="6">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="186"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="231"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="237"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="284" mass="34071" checksum="2C1464F9224A004F" modified="2013-03-06" version="1">MNEYKKQLLLKYYQLKSFYKRLSVIKKALHTRQSLFKYPVRSQDKDLNINRIVEKRNIMELMDINNTLWINIESICGSRYTMYGKYLNKYCTHRKDDELDTTLGGIDGRCLLPVAIENRIQPIVLMRKILALKKTTKDKFTSSEIDKLKDLVSKHGNNWVIIAKYLNKTPQQCLQCYRRYIRKSAGRWSKKEDELLMQAVQKFGKKWITVSEYIGTRSDLQCRERYINVLDVDRKEWTKNDEEELKQLVSKLGQKWKEIGNLLGRNNKECRRRYFKVIKKMKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVW7</accession>
    <name>L7JVW7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1886"/>
    <dbReference type="HOGENOM" id="CLU_1171328_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVW7"/>
    <dbReference type="OMA" id="KHARISI"/>
    <dbReference type="OrthoDB" id="10501636at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="237" mass="26285" checksum="A305C32A78A423C0" modified="2013-03-06" version="1">MHLRTKKISIYNMSSGWDKATLLKFMLPIMLLASLTMCVIATIWGDLHTNKLFETTFIVVSIATFAYIIFVEVEKYILGTNKTNKDSVNAFLMYGLIIIATVAVIYTFINCYEQLPLLPAFGFLLTNVTGIFTGSPGGISLMVNIALLLLCGFAAFVQAKTSYEITGTLSFLIVVAFGIKSVFFKSTDDDKKKKDEGVLKYLTLVIALIAAVLFMYTLVNSELYYDALFSQKDAVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW66</accession>
    <name>L7JW66_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein required for 18S rRNA maturation and 40S ribosome biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW66"/>
    <dbReference type="STRING" id="72359.L7JW66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1370"/>
    <dbReference type="HOGENOM" id="CLU_055846_1_3_1"/>
    <dbReference type="InParanoid" id="L7JW66"/>
    <dbReference type="OMA" id="ECKFSND"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="20999" checksum="92CC864F5CAABF0D" modified="2013-03-06" version="1">MIKKIIFFIQEAPFTGTEKHKVAQSRPAAPPRPDITHHILLTIIDSPLYKSNRCKIYVKTVNNILIEINEGTRIPRTTTRFVGLMKDVLRKLKIKDEDKTLMRVVKSKIDFPPGAVKIGMSRKGERISKEHFIANDVVLYVNAKQRGEDVFDDVDVLMKVSDYELSGAAAVGKAIFFIEDILNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWB4</accession>
    <name>L7JWB4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pattern-formation protein/guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWB4"/>
    <dbReference type="STRING" id="72359.L7JWB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1366"/>
    <dbReference type="HOGENOM" id="CLU_278749_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWB4"/>
    <dbReference type="OMA" id="CYMERIN"/>
    <dbReference type="OrthoDB" id="2194340at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="302"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1136" mass="131844" checksum="46342FA266B49C99" modified="2013-03-06" version="1">MQNVLLTKTKILQAILQIRSYPFTSHDLIVIKQKMHHISLKELSVWHIKHVFLEFVRVRKFRNSEMQFVLEELVNVVGLFDELDVVGECVMELLYENDRHVYEVLRAHFAVLYEIMEYYGENEESAIVRCFNEGMVLTDDGKGAVGSTGHVQPSKDQFCKLSRKTAQKIFYELFIALSHFKNKQLVFFLKPKFISLVNRKTLKRLYLQHKMYVVVPECLNLEVPTERALFALNHRDIASFVYSTVFDPYLFQVSPVQDVFYESVFFLFLYFDCEPMMEDLGMQMFVRMVDENEIIGVIEHAEHEEENEQNVKLRDEAKNDQYEGRDERNASLHVKHRDEKINDQHVRHCCERLKQYDPQSKDVVKQKFAHFSANGDALDFENKHLILRSFPLNKRSIGKFLSNNPSVLKEYLTTFDFTNLDLLGALRAFLRNFYLPTESQAINKILSAFSERYYECNKEGFGSDGNELDSIVCGNGGDVKRVNGIVGNENAGAESDEIYDGEDVVRGDDRGDNGDDMTNVRGKRLPNESDTPVQGVCEIVNQNSIDNLMKNSKEHAEKDAVKTGTRNTAFDFDSVDILTFCILCLNTDLHNAAIRVKTLKLSFIERARKCNLSYFFSDRYLSYVYDSVKKDPLVTDSRFIHSLETYRAYYQVVRHSTFYTVERMDVCMSCKRSIIREMCAHNRERVFRMVPDDVIRVIRFSSDVMTMIDYCVWYGDRMRRERMESFFRVFYAVLEMIEADGAWNGEGGEEQYVFLRYPLAILNKYKRKNENFFFKRSHEADRMKATLYKVIGSGNDAIFSHFIKENVTHNLSALVRKNVFRLGILDDDVLEKVTCEEVLIIAKELELYDLFYRMLNLKDFTAFILKNDWIEMSKVKKKWITADLVMHREEIGEEMFGYLNEDVNLLVYFRKCKSVFNLEWLEHILKGSQKCYMERINVKDDRLLFMVSVLDSLVNFDRNNAADTDADGAAGVITARDDNTNGGSDTIVKDIPIESVVSRIEDEKVFEPVNPYEYLTSQMVSRLSRDERSVLMKNIKKIIALLSLSLPLIIKIVRLPVSDVLGKELAKVFTKRIKYKNVCANECEHTVDVDGMIEYIQARGWISVDKDATAELTNEGKTAVEDAGVGEKQKENELDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWB5</accession>
    <name>L7JWB5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1421"/>
    <dbReference type="HOGENOM" id="CLU_2352425_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWB5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="97" mass="11440" checksum="4C78DF7A33D734C8" modified="2013-03-06" version="1" fragment="single">VRLFMLYHININAHKFFLFSIRVAPTMAYKAAIQLPPELTRKDIPKNLRNNEIFSCKNKTYICVEMPIKDLYCCGIENETTTQLPTEVHSFFWIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWE5</accession>
    <name>L7JWE5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase FCY1</fullName>
            <ecNumber evidence="2">3.5.4.1</ecNumber>
            <ecNumber evidence="2">3.5.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.5.4.1" evidence="2"/>
    <dbReference type="EC" id="3.5.4.3" evidence="2"/>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWE5"/>
    <dbReference type="STRING" id="72359.L7JWE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1668"/>
    <dbReference type="HOGENOM" id="CLU_025810_8_2_1"/>
    <dbReference type="InParanoid" id="L7JWE5"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF179">
        <property type="entry name" value="TRNA(ADENINE(34)) DEAMINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="145" mass="16369" checksum="F0ADBDCFB5A659F6" modified="2013-03-06" version="1">MTSNDVKYYMKEAINEAKKALIVDEVPVGCVFVRNGNIISKSHNLTNKLNDPLAHAEIVGIRSACCKNCDVYLTCEPCVMCFGVLKRLNCTIYFGCFNPIFGCSLVETSDNVFLDNQECVDLLKLFYKNENSNAPIEKRKIKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWG6</accession>
    <name>L7JWG6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septin family protein (P-loop GTPase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWG6"/>
    <dbReference type="FunCoup" id="L7JWG6">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1694"/>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="InParanoid" id="L7JWG6"/>
    <dbReference type="OMA" id="LYVIEEC"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="348" mass="41378" checksum="C9A576017318650E" modified="2013-03-06" version="1">MQFGGIGISNLPNQHCSNSTKKTHSYNLIIAGARGLGKTTFMNNLVRKKIFKQSLYLEKKDDGLRELQFIENDIFSSPKPYEVGDEYIRYDEGEGWSTTWLEEHKVAFELTEAQIFERGIRVNFSALEVSNIGDCVDNTDAHIPIVDYINRKYKEYYENERNHRRDEIIDTRIHACLYFFEPAGHWMREIDKKNISEISKICVVIPVVARGDIFTMEERELIRNNFQKTLEEEKINLYKHLQIVPFFIISNHIDEFGIVYERQYMWGSVQATNKYICDTEELRNVVIRDQMLYVIEECDKFYRLYRSSILKDELIKYVKDEAKIKNYEQEEFEKFLLEWSGDHEMLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWI8</accession>
    <name>L7JWI8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1245"/>
    <dbReference type="HOGENOM" id="CLU_2887426_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWI8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="63" mass="6744" checksum="3D056622442C72C0" modified="2013-03-06" version="1">MPGIRAAYPLSMVSVLGIRATLNAARPSRQYRMAKKPAIQARAALSGRGVTHSRVHELSTALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWX6</accession>
    <name>L7JWX6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1100"/>
    <dbReference type="HOGENOM" id="CLU_2243088_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWX6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="105" mass="11991" checksum="8B65DF7E4E910B6F" modified="2013-03-06" version="1" fragment="single">VLAVLKVVQVVQVALKVVQVALREVELAVLREVQVVLKVVLAVLKKEVLSLFPQVHQAELQNQKHQKRCQLLSLKVQVQERHHQHQANRLQVSHRPLNLQGDLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX03</accession>
    <name>L7JX03_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
            <ecNumber evidence="1">3.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.8.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX03"/>
    <dbReference type="STRING" id="72359.L7JX03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1449"/>
    <dbReference type="HOGENOM" id="CLU_059493_1_2_1"/>
    <dbReference type="InParanoid" id="L7JX03"/>
    <dbReference type="OMA" id="KRIEHIC"/>
    <dbReference type="OrthoDB" id="2195201at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018784">
        <property type="term" value="F:(S)-2-haloacid dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18572" checksum="21669A2CE0393CDC" modified="2013-03-06" version="1" fragment="single">VEESINNSRTEYSTALKYVLMKRHLSYEEYRDYVFPEIDYDGILKKDENIIKLLESINKPLFIMSNGTKEHVKKTLTTLGIEHLFKAVFYLGYDSNNYVGKPDVEAYQLVEQLTNARKIYFFDDKERNTSVTLSPKWSCHVTTYENIHNRLREVLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX67</accession>
    <name>L7JX67_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1718"/>
    <dbReference type="HOGENOM" id="CLU_531201_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX67"/>
    <dbReference type="OMA" id="MINTHIE"/>
    <dbReference type="OrthoDB" id="10685456at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979219" evidence="2">
        <location>
            <begin position="20"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="513" mass="57966" checksum="0A33F3574778670E" modified="2013-03-06" version="1">MSIILGILAILSYNQVSSTVMIHTGNSFLANYNKSLANSNQNVCGDKSNNELNGEKPGECKYVRITVSTDMEQYIKGTELKQLRGSFGPLIRQPVLVNIDIKHRSAENRKKCILYYQLYITKLSLLEVQLNYNSWLLEQHSYYLRLIATLSELITLKLRKIALQLILLIKKLCKLVDLYIKRLSDEINDKRKHCIPCADDAPLVDKLVWLRLIKMGLELLEMSIINSDILGTKSNYSSSASYGKDHGSVFPKDYKYTPDKEVSQNLLSKDEKYTQTEGSEHAAEIDVYAAGNKLENCSDLVSSSCSQRNEFIQDNDRVSKSRANVGNDDACKANPIMNFNDTTNTSIEECVGGKYEMLRITLHITSKDQVYERTETFVGSKSLTNYFVHEGAIGKYEKCYESPRVTELVNEIKEAQRCCCSTNCCTKSSAESTAGDTKLEDEHILVDEQTKNKKGSTESRAKINSESVYQKGTKAGKVKKIIIVICILCLLIVVLAFLLTCIYRWKQIKELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX84</accession>
    <name>L7JX84_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TBP-1 interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993903">
        <property type="protein sequence ID" value="ELQ75920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX84"/>
    <dbReference type="STRING" id="72359.L7JX84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1118"/>
    <dbReference type="HOGENOM" id="CLU_858385_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX84"/>
    <dbReference type="OMA" id="LCENMNI"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="8">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="208"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="324" mass="36801" checksum="C2A257F9B9790E65" modified="2013-03-06" version="1">MRMHPLMPTEKKNAKRKKCTLVMKKKENECIENEINEDDKEKENNTEEGSGTCSDASADEKSTDDESSEECKSSRAKKKEEKKGGRESKNTQGKNNKKGINSKKSINRNKNANKGSDESDTYVGTTRRNSTQSSAEIERNVLNHMELSYRPHSVQDLLIAFKNEIKKSALVNALDALVEKGRVISKAYNKSAVYLYNYANAGDNSGDMHEVEQCIKNVEQEINALKDSIARLREYPPDEHLIRMIGELREKKEKVRVEMEEIRKAGVDKAEYDRLMSVYKRMAGIKKCRMGILRNVVGELCEGMGKKRGEIVEELGLSEEVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX93</accession>
    <name>L7JX93_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1096"/>
    <dbReference type="HOGENOM" id="CLU_004199_2_0_1"/>
    <dbReference type="InParanoid" id="L7JX93"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1278" mass="149186" checksum="A1586B06D6A158D4" modified="2013-03-06" version="1">MVTASSHEEEYKIPLYIDFADHLFFPIPMHYCTINYKMLQVESFDFSFVYSSTIGLTIDVDFTGFLHKKNDIAQNRPPVKLYSLIHLENIYKMLCHPFISPDYVKTVVLRFSFIKYNIDLSMLRGKHIHLHCSNCIFGEETRLSQNLLVLHDQNSLIDVNLEMPHGLKTLKLANTQIGQNKVLIINEDCRKIKITGTTGTIRYPSVVNLDNMEFRYISWVLKFYIQSSRYFDKLYIKNVTFNSSTELGRDIKEIQLVNIIATNDAVISIYKSCQIIVLENCVGKFDLSKMVTWGRFEFKNNTSTFRLVNQKEKNIYEISMKNIYYDKTLESNNLGGEIKAIETLSDGPLNIMMNMNREHVVYKNKQWYVDIAFLLYKEMISKQHLTKNTYFYHFSSHGSNKLVIENAKLKGTWSLAKNGFREVILIDVQIEQDRFFEIDTECTSVFLQRCTGRFIIPGISSDKNEGINLSDVENSILIYKVKENIYNYELSNIQLKGNIVFTLVIHTARLTNVGSNASVDLKFMKKCEKLYLKRCQNIGIMSSCSLKKLRIDNFSDDWIRFCTAMSVHEFELSSCYNSMSNFFVMDSVKILQLYYIRLAENASFTIDQDCWKIAIKNVSGQFNIFYILKQSNNSATLTLKNGSFVFDKQSQNSRNHLLLKNIILHHTTEIQDNIHDLSLISITLVTNAVLKVNKECENLLIETCQCAIDFSRCIHLKSLYLYDNQFIYYEEIYKNINWLILINVKIDASIQLGEHISRVDLENINVLWPYCLNIMQNCEMVRISGSKGKINAISLDSFNDAKFMKEGTGIMHRRDVNKYGTSIYLRRVKIKRNYKLSSNIECVIANNPVMRKKAKLIVGSMCRYIKLINYLGIIDLSEVKVLKKAVFINNLPVIEDNRMQKNISSGINLLFISSDKKIIMPEYIESIELKNVTIKRSYTLIVGTDSKNVSLIQCKGRFDLSMIVHLKKLKLVVESKLVEILFPNLDSVENLEISYDDNQEYFEFLLHNCTNTKKLVLHNFVCELHNYLERYKLDILDANEYLWCLNEQSIETNNSAYLTICKQPGMLFSSWKYSCKPMFDQTRYKTLRWLSIRFFRFSEECVMMLKKFILLETLLIVLSHAPLDIFLHLPPNLKKFTITLVSCCITPYDCVTPMKINDRKINFSNRMLAWLRIHLLLLLAESKFTCFPKKLEYLEIIPYHSVKRNLEIPSFCKLKVRKLVILQIDEIMKIKIEKIRPLDEYYSNLVDLLTYFVDFEQLEELSIYSNNQETKLNPSNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXE0</accession>
    <name>L7JXE0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1610"/>
    <dbReference type="HOGENOM" id="CLU_2005503_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXE0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="124" mass="14481" checksum="EF8576A99F98FF19" modified="2013-03-06" version="1">MLIAGTITYIFYRNLRNSFIVKSRNEIANKPLYEQTNNDTKEQIIASKAVDSKNRHEENISTNHIDRDAEINHPTKPKFVNKPTEPMNIQEENSTKPGLHVIGKVYFFIHTGETNERKKFIFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXJ1</accession>
    <name>L7JXJ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993867">
        <property type="protein sequence ID" value="ELQ76158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0874"/>
    <dbReference type="HOGENOM" id="CLU_2967565_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXJ1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6766" checksum="63381584B3BC7926" modified="2013-03-06" version="1" fragment="single">VAMAGYSDQKSKFDWMMCCEVITKLIFCKKIPKASEGLFDKENIVEKEIISIFSRIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXK6</accession>
    <name>L7JXK6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0965"/>
    <dbReference type="HOGENOM" id="CLU_2098535_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXK6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="116" mass="13568" checksum="46A52E2C39609877" modified="2013-03-06" version="1">MNQSDLSSNMSQGIICVMVEQMLSFLTLTKLTEQKMCMLIRKECENVLDEQKRIVYEGEKFLKCVKEIQETHNYTISTELVKMLSITIEQMYFIEQSLVLFAKPLQKFLQGHSSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXL5</accession>
    <name>L7JXL5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1252"/>
    <dbReference type="HOGENOM" id="CLU_1120784_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXL5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="248" mass="28624" checksum="80CD9D8474C99F49" modified="2013-03-06" version="1">MKNWLKFLLLLILFAFIFLVVLPILILQVALKVGTYTYMQHSKSTINKFFADVQAFASNKDVISNCFCSFTSNYTETGHSIRLKVLMKPNVQKNEFDRFKRQIGEKGYFQTFMTDFVDDPIGFQLISIPHSKFTKETVIPKQHTFVNLATLIFKESIFSKVDKMINFLLGNKPFTVLKPNVFILNYDTEYFTIYEVETDIGNRLLKLGRELRVKATPSEAATIYSNIAMTIICNCDPPSLVNNLFVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXU2</accession>
    <name>L7JXU2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0790"/>
    <dbReference type="HOGENOM" id="CLU_1338436_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXU2"/>
    <dbReference type="OMA" id="ERCEHPF"/>
    <dbReference type="OrthoDB" id="10365106at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="171" mass="19911" checksum="1C6A39229C349148" modified="2013-03-06" version="1">MITAEKCAYNENVVYDYEMDVYKSYRGILMEVERKAKNKNSILTNLRKYHNDTTSTQNENDHKTLDDSVASAGNNVPVEYKIDDIMNLLDKLNDKVVDNLKSNVFDLPLHQIYGQLMLYLINSRPLPSNLIVCEVCSNLHAKVERCEHPFHKEYEKLRTVTEQLSKKLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXZ1</accession>
    <name>L7JXZ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-arginine dibasic convertase NRD1, Zn2+-dependent endopeptidase, insulinase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXZ1"/>
    <dbReference type="STRING" id="72359.L7JXZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0644"/>
    <dbReference type="HOGENOM" id="CLU_009636_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXZ1"/>
    <dbReference type="OMA" id="DETVYHY"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="762" mass="87380" checksum="0A2464CB6A0874DA" modified="2013-03-06" version="1">MLVARVKMKCRTKTKNAPKINDFDSFLNTYNGDSNAYTAEDETVYHYELDNAGMLQSFRLFSNFFKHPLINKRTVASESQVVDSEFQNRKNDDESRINRILEISAGKKFSIGSLLSLGNDYEELKSHCEDLYAKRYRKMVLVVCSSERNEDMKKILEDSFSLDLDAVVYTERTCVICSKHGLNGKLETEHEFKDQEHVPNGESQSAEDAFKEQQNDGNDLKITKLYKYRPIFPKKRVIVSVSLPSEHVQYHNVYDSLIYFFTKEDHSSLLYALKNSRLIFNGTVCTTTTQRETMVCFDFTVPSTDTYTAIVHEINRYFQIYKKSQGILSYYSKIEKDVNWQLYEEDDMRAHVVDCAERMLRSKVLFSDLMCEHECTNLALNECTVVLVDDDYECEKVAGDEYELCYEEIKCVGCADDRKLGPSVLNGSNCVADDRKSEHSAHENISTTNTQPVNLHCSQRTPGEQNDRLFTMRHPVGSIIKDKDVNAALKVIESAQNKLVFIKDSFQTTKTVIQLFLCYRTSIMDVINFTELIDQLNVVYNHVLRTNAISVTHHVFHDGVLFEIAGLDPFFVLLNVLNFDGILEMMSSTTCTLNVLNDVKVSLEDEMYDAGYVRTSNSIKNVYIEGYSTVEREYEMVKDMIDDLRVRESAGTGKTGTSRQFIPYNEVQSVLLIVNGCSNEECYHDVFKKICARIKGKGSAPKLRIREEYTCTQDVFSVLNEGNKKFSRKETNGRMSTCNVTSPERVGDKPMKLNECLVLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYC7</accession>
    <name>L7JYC7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYC7"/>
    <dbReference type="STRING" id="72359.L7JYC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0966"/>
    <dbReference type="HOGENOM" id="CLU_1176189_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYC7"/>
    <dbReference type="OMA" id="NRGQNEN"/>
    <dbReference type="OrthoDB" id="10626381at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979241" evidence="2">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="262" mass="28710" checksum="9B583E7B9334D5B3" modified="2013-03-06" version="1">MNFFLYFVTFVFVHAMMRKNVDYESWESRLAAANDKSSGSNPSGSSSSGNKNKDKEKKPPKEEKPKGQNDQPQNDSSGGGKGGKGGSGSAGKGTGNGSSPSGKDNNPKEEETPENGDKSKENPEKDPKDEKNPKDEEKPKNGEKSKENPEKDPKDDKNPKDEEKPKNGEKPKDEEKPKDEEKPEDEEPKDEEPKAEEKPEDEEKSKDETGKGTGILWNSCCGDDLGLEGGFNQGNQNTMNAGTPEIVISLKHAKNENKEQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYD8</accession>
    <name>L7JYD8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0976"/>
    <dbReference type="HOGENOM" id="CLU_2063254_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYD8"/>
    <dbReference type="OMA" id="YTVCDED"/>
    <dbReference type="OrthoDB" id="10455777at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978888" evidence="1">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="14040" checksum="B90E81828354D791" modified="2013-03-06" version="1">MARMLMNLGLCFYSLILAIYGKSIVDNLRSKYDIEQIDGSNRIEESNLADKKNEEEKDGKYVYTLCDEKGTEPDTFEIRKEEGTKEDRNKKQDKFTYTVCDEDSMEKSNQVHGNQGKTDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
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                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ76101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2098674_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYH6"/>
    <dbReference type="OMA" id="TCFYGEM"/>
    <dbReference type="OrthoDB" id="10348990at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="129" mass="14802" checksum="D2B4449A360777FA" modified="2013-03-06" version="1" fragment="single">VLDRFINSRPCDPLVDYPMPLKHTKVFTTEIHSIHVFSPPLRVEMVGIVFNKTKRTYTLLDFFGTCTILSSAQKLPIGTLCRIYGLVSGKGRVIITEWEKTCFYGEMMFLGEVVSLRKMKFYCGRKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYI7</accession>
    <name>L7JYI7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1263"/>
    <dbReference type="HOGENOM" id="CLU_483298_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYI7"/>
    <dbReference type="OMA" id="VEVHHVI"/>
    <dbReference type="OrthoDB" id="10342475at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978898" evidence="3">
        <location>
            <begin position="20"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="582" mass="67645" checksum="0DB74DDC619ACD1F" modified="2013-03-06" version="1" fragment="single">VRFCQAMLHILLFVWNILGYCSNSTENIVRTTGRKQNVSGTVIVSGMTTGSTEVNKGNKVEVVHVVEKSTAGKGGSVVEDGAKQSKTASKKVIFENDESKNINESSSASSSSHTVVMTEEHTRSTNETSEEKEVKARGLYTDAIPETIAFQVYAKRIHNGETELSYSNYTKTMREEIQRLREEIKTLSQKRNTQTVILQAVEQPEERSAIEYSTVEYDKELEILKQRKETLINEYQKLVQIHTRSTDERAYLEAEVKTRREELAKLREEYERMGNDGSFEGYLQELERLYEQNENRIKQLEQEIRRLRDENNRLENEYDENAEVHMKALERLLAEIKAIEQEIQQLMSSMDELMIDVEEQMQEIESEIRIIEEQMEHIMSERKTVITKSAPKKVRVVQQAVQPVEVHHVIHRVEKPVIQPVEIHHVVRPVTKVTTKRRMVKPVVKVVRTVPVKTVHHVKRIDNRVESTVKPSVKVHHVRKVRRIVRPVVREQRERAAALKSRKVVLVKEQAKEHENVQSTTAQKSRLVRPERMVVLKASHDDDKKDKKQSGEPEEDKKRIFEDDGNAITRMRYAFWNMTRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYJ5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi incertae sedis</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0532"/>
    <dbReference type="HOGENOM" id="CLU_1760069_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYJ5"/>
    <dbReference type="OMA" id="WVEDEES"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="17294" checksum="2AD39FD89EFDC364" modified="2013-03-06" version="1">MLDNKLFTMDYEGYALPCEDVDGYAENNEVDEAQVETMQSIPSCYYGSMNIYIIIIIIGISLLSLAYLLYCMMKRCENCRTSKKEKKFTRLRNKDLIRKKQNDLYDSKYDHSNNLMSSESLNAKTHSSDWVEDEESEYEDCISQVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYJ9</accession>
    <name>L7JYJ9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
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        <name type="common">Microsporidian parasite</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76509.1"/>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0537"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="6021" checksum="8165230E2CC4CD8C" modified="2013-03-06" version="1">MQIYDKVEKIGELQRKYNELRDEYKNLKCKYREKHLIEKYLKDAISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYM4</accession>
    <name>L7JYM4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0602"/>
    <dbReference type="HOGENOM" id="CLU_1791571_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYM4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="145" mass="16742" checksum="C6E204408240E356" modified="2013-03-06" version="1" fragment="single">VLLQNIISLNIVHGLNPLGSLTLEPSACSMEDDLQQFLEIERKRKLMVERSIQELINRRKILNEKMQQELQAIMDDTYAAQEYTNVKAPIIEHTGKQQPTRNEAQNTVERQPVIHPGAEVAPVRESERHQAPPNTLQYTRLRLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYR8</accession>
    <name>L7JYR8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0574"/>
    <dbReference type="HOGENOM" id="CLU_373057_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYR8"/>
    <dbReference type="OMA" id="FACYLFT"/>
    <dbReference type="OrthoDB" id="2198293at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="745" mass="87780" checksum="B97B56D9D7435989" modified="2013-03-06" version="1">MNKEISDETVLEEIEKINSCKKSNADYYINLINLEDNVDKVSLFVSIQACTVLSEDFYVYSKEEKASIYVEKGLLKFDQIVKMHLIEKKDFYSLVECLSRMLIVRVKITNCLNILSRYQSFLLINSEKIFNFLLDTQDEHTEMKITIDDTKKEHILVEEQQEIEEFASNGNKLLFATDFISTNEQFDIFLFFFGLFYDPAYKSAYLNKLANLRKKFERALLIEVVLNTECIAELADYVIKQKNGLNELSTIFMISLKINELNTFKVIIIDFLKIANIFTDEETANLRLITTSLIKNLNKETNDEQSLKKRSNTMNIIKLDNINFLLDIDMKSLIDWDDLVRFLHIQGNYAMILCLVRHGIKVERKILFACYLFTDDIISADKLYEEELQERFTTKAYRQDVSCDEMQENEIFAESMFKNDLIEQTHIFIFFMKKGRTSSAFNIMEKIDTVDEFIVCMKTLLPYDRRFLKDAIYIGIKKFYLNHNFLKISLSILHLEDINVTADERATLILELYFNNNDEPVTRLWPDETFVYNILYNNILEVTDLDLKCRLLKEIRQISMNEDTLFLFLYVMREIEQKMFVTNTENAKPGIRAVESLTTSISDILTYLFDKINTFKPETLILLYDYYKQYDKDKSDLAFNYIPICDLSESSLFFLCDITDDTKIVRIVQAMQTKRLLTTAILDSIYVRFSAYGVYNLIALCDELEMKRIEFKSDTLHNLLRTKLQYLKALKDLRLKRRILHFLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYU2</accession>
    <name>L7JYU2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0518"/>
    <dbReference type="HOGENOM" id="CLU_872087_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYU2"/>
    <dbReference type="OMA" id="IRILDFQ"/>
    <dbReference type="OrthoDB" id="2191410at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="317" mass="36749" checksum="4A42DCECF26CFB6D" modified="2013-03-06" version="1">MLNKEDNFYPTNRIEESLLSKTARDIRILKREIREALGSPAKLRYLVDFENGAVAYNPPKIFKKIVIQKKWSSKECARRSEEYYREISNLPIRFVLMGSDKVVFTEEWVYAIEERKNLKLLRKINFYRAKLFEDDDEEVCEGVVMNGGLKSTGYEKRVGDRLSGAERAVNGGQSKIDVPGKCALIADENINVDQHLHAKQMIARKLAHEAKAFIQKNTLYEDEEIRILDFQSTYTYQKQEIEEQPKKTKEYAKVFELMKSENSKTNFKIPNIKKKGTCHSSHAAALSKIPYDLSRMSMPTEILSYKTMRAGNNIRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYW3</accession>
    <name>L7JYW3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993899">
        <property type="protein sequence ID" value="ELQ75947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1091"/>
    <dbReference type="HOGENOM" id="CLU_3038212_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYW3"/>
    <dbReference type="OrthoDB" id="10390666at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="6576" checksum="63D5289863D1572A" modified="2013-03-06" version="1" fragment="single">VKEIHSKKNLRYGKTGRIVEEVGKENYLVKIFKRNHYQLTALALRERAMQGWWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZA1</accession>
    <name>L7JZA1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993819">
        <property type="protein sequence ID" value="ELQ76744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0261"/>
    <dbReference type="HOGENOM" id="CLU_3227277_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZA1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="4891" checksum="4FE1A6F4143371F9" modified="2013-03-06" version="1" fragment="single">VTHLHVTGLLTASIRRFCQRKCPLSGSRGLPTRPVMCKEVGDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZF0</accession>
    <name>L7JZF0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophosphatidic acid acyltransferase LPAAT</fullName>
            <ecNumber evidence="3">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.1.51" evidence="3"/>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZF0"/>
    <dbReference type="FunCoup" id="L7JZF0">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0193"/>
    <dbReference type="HOGENOM" id="CLU_041302_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZF0"/>
    <dbReference type="OMA" id="IHTTIPH"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="357" mass="41982" checksum="1A4CF47C874C7500" modified="2013-03-06" version="1">MTMLLFNALKKYVVIPLASIVYITSVTVGFVVCGFLKLILPFPGIRQKIVAWQKCEWLHLTIAYGCIFFPHPVYVAYNKQILQKKRCLVISNHQTNYDWLIILIVLQKFDMYRDVCILVKSSLAQIPIFGSAMKAFGYVFIKRSWSEDLNTLKKSLNYLHTKSKLFFLIFPEGTILVPSTHSKSITYSQKMNVKLRDTSFSPQNVLIPRTSGTNMIYNELKDTMEGIIDVTLFVRPYYQYPQKTFTYTDVYFRNVGKIGFFFLVDFMNNVTSKDWLYEIFEKKEILIEKYKQSCQLFKSIEDVNDFTKKFAKIKSGNYDFIEITLIRHRNLLYLLYFTVWTIGMIYLVSMAAKWLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZJ7</accession>
    <name>L7JZJ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0084"/>
    <dbReference type="HOGENOM" id="CLU_3417318_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZJ7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="26" mass="2944" checksum="905F95DBC8B697EF" modified="2013-03-06" version="1">MLDGSFKDLRLKIKSIIAELSLMTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZK5</accession>
    <name>L7JZK5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993809">
        <property type="protein sequence ID" value="ELQ76869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0128"/>
    <dbReference type="HOGENOM" id="CLU_2489564_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZK5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="87" mass="9875" checksum="50D4299D71E22F00" modified="2013-03-06" version="1" fragment="single">VQNLMLTEFKINNYDVIKDPLNVFEPEREQQSNANSEIGNASTNRDRYCSSAFSENKNELSSNCKNLCEIADAIIALSKFPLQNPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZN7</accession>
    <name>L7JZN7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0544"/>
    <dbReference type="HOGENOM" id="CLU_853100_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZN7"/>
    <dbReference type="OMA" id="IHTEVEC"/>
    <dbReference type="OrthoDB" id="10333653at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="322" mass="38583" checksum="FD72C755040A64D3" modified="2013-03-06" version="1">MKELFERKQNLQNKNSHLYLQARKEIQNNLDLYKNAVLIYEQIDAKIYDTDWVFELPVQRLNSIIDTLGTNLYIHYEQIFFPKDKLRYFLTKEYSDERKIPFDCENALRLLYIYTVLRDKIRQKKDEFGTEKQSRNTQCIHTEVECFGPPTDTFHAEIDLINDIISLFSGSTFISRSKVDVHPWDIPDDLKVRYAAPFTLKLEVARFKRFELDHKLTFIEKFVSVMTNEDTNVYETLLSFKFNDRFRSLKFITNGCAMDGTAIRERVQKIEKVIFERFNDDYKSVLFLSYVIYVCPGLSSALSFEHLKENRYYYFLKWTEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZQ1</accession>
    <name>L7JZQ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0818"/>
    <dbReference type="HOGENOM" id="CLU_1760071_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZQ1"/>
    <dbReference type="OrthoDB" id="10505480at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="17346" checksum="DD6979098C2937B6" modified="2013-03-06" version="1">MSEEKTRHEKLRTKLLIMKIILILSTILFVLCLVYFVLYLVVMFYNRSYINRLNEKSKEMNYSQKISSFDNSYFIIDFTSGGDEDSPILRQVQVDTSSAFIVNDILKGNEQENSKNMQKNYDSLNKFCLSRSSQLMPLPNLNKKDVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZW6</accession>
    <name>L7JZW6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0142"/>
    <dbReference type="HOGENOM" id="CLU_854082_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZW6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="326" mass="37574" checksum="C1582F1F2F8D6351" modified="2013-03-06" version="1" fragment="single">VVFKLSCLPPTMQKKDEVREQVARSTINEEAPVRNGTRGFFNSLTGQYKYNLMNPKIYLWYFLVFAASIVLMKVCVLITRLLVVDYSNFVFEDIRYDAVDNPNIIKVTLMSKYKCPMNAIVRSLSIAIFNNGENIVVLKKDEFELEKNGRLGFSGILNIAELHPKEVLAYNCNGNLSVEISSAVTIRFFSFYYTFHFQRKRSVSQQRSKNIYTVYLANISLIGQKQINLNIINTGQMFAEHINLRLPPVFFDAEIFGKACVITLSPVCVNRGRVSSFVSLSLFFEDILDLTYLFRYTYKLLSDNFELSTDENLRVPLRVKCLKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZX5</accession>
    <name>L7JZX5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
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                <person name="Schweder T."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
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    </evidence>
    <sequence length="83" mass="9969" checksum="4A599CBD0CAE31D6" modified="2013-03-06" version="1">MKIFVPFSMLLPVLIELFRENNSFTHTSQALFAVNEVKPEFDKDQNDILKVTFYNNQYDIFYYRIKEENGIKEIRITQILTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7K066</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">THOM_0499</name>
    </gene>
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        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
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                <person name="Schweder T."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="77"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS52002"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K088"/>
    <dbReference type="STRING" id="72359.L7K088"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0230"/>
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    <dbReference type="OrthoDB" id="2190004at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0418">Kinase</keyword>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="36"/>
        </location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    </feature>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="307" mass="36794" checksum="4868A00B4E5D13C6" modified="2013-03-06" version="1">MPFKIFPNLVNGSFAYIFFFWSDLHFVETLVYYYYLTVNIKSFNTKENILISLCVPFIRENIEDQSLFNAVFYYYVINPEDKWMIGQIFELVATFRMDVPRLLIDYLLYFLFYYKLFVFWMIMITLLFIVQLSILRCNNNWKRKAIHFFMLPCISNMNYFTRYNLDIIILLNVFLSVNFKRSAFFKHFTSQKDHGNIPISNVLILCSTYYPYYFLEKCEDFIALLITVFMLDSVASIIGTYLEKKGKSIQGMLSGVLSAIVLHYMLFRNFNYVFYYFTMGMIEYFVSCNDNLVLPFFSVLFFKFQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0F5</accession>
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        <submittedName>
            <fullName evidence="5">Structural maintenance of chromosome protein 4</fullName>
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    </protein>
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        <name evidence="5" type="ORF">THOM_0018</name>
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Noel C.J."/>
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
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                <person name="Becher D."/>
                <person name="Bernhardt J."/>
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                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
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                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="486"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="169"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="339"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="634"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="709"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="778"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1132" mass="132315" checksum="0653DFF307EFB62F" modified="2013-03-06" version="1">MQQKNIQQDRNLKMTDITLYNFKSYEGHHRISNISNFTTVVGSNGSGKSNIIDAVLFLFGYSAKKMRHKVNSGLINKGKDSCYVEIKFTASNDQFSVKRELIKGRSLYYINDKEVNVAEVRDKMKYYNVDLEHNRFLILQGEIEAIAMMKPKDEKNVGILEYLEDIIGTNVYHDEIQVLEQQLSALKEKEDVMKSSFKFQEKEFNFVRAKNESNEQLLNERAEWLKEKIRLNYLEEIKEARVRDKLMKENKSLENELSKIKNNDDVEQIKMLEGELVKHKSALSRKEREFLSCKQEVNRINREILRRESDYEMLVRTEKMAVQEYENTIREQKMNQIEVEAIKTEKDENMREIDVFEKKLRAKEDELVRLRQNCKHGDKIRALKKLMDRYEKDILNLNEKKSRIRLNQTQQDEVVLRNKILECEKNLNILKGLDRNICTDMRVLKNNIQATEQELESKKEQLREAKQQNTTRKTESELIGRLKGVEGFIGRLGDLGRVNSKYDIAITAASKGKLNNIVVKSVESAENCIKIINTNGLKRTSFLVMDRLVDEPLKKDKDFVYCVDLIDCKEKYKKAFSFVLKDTILCNDLDEATSVAFDRKIRRRTVSLQGDLIEKSGIMSRMKVTGSMNTQVDTEKLEKKLARIEAAKSNMENLLKEKEEQIRAVKSILDGRKEANECINDLEQKMGRMIDSYCKLTNKSRTDDLNALFRDDNEEMRALDEKVNELKNEIKGVRKEIEDLEGNEIKGRTCDKQLLTDQINLFIKRNQDLDEKMNRILLLDTQSKLKNVDNTLKDARRKMKEIESMDEIKKECNSKTKLCMELETVYENEQDEIRRLCEQINDLKNVTEELMQKELEIRNRIEKNLEKMKKKSMKNDHMDELKVFKRLGYRFDDIMGSENDDNISKKVVDYKTIDNTELDNLIGETQFKIQKLDKNEKIDFELVHEYKNKKIEYENVKNEYNRFMNTFDTIVKQFSDLKNKRHEEFMNGFAIINKHLKEIYQTITFGGNAELELVDYTDPFSEGVVLSVMPPKKTWNKVSSLSGGEKTLASLALVFALHTYSPSPFYVMDEIDAALDFRNVSLVANLIKEQKGQFLVISLRNDMFELADKLVGVYKNEGKSNIIVLDADAIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0H7</accession>
    <name>L7K0H7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-binding protein RANBP1, RanBD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993817">
        <property type="protein sequence ID" value="ELQ76752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0H7"/>
    <dbReference type="FunCoup" id="L7K0H7">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0H7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0245"/>
    <dbReference type="HOGENOM" id="CLU_998143_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0H7"/>
    <dbReference type="OMA" id="SANTFIW"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="150"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="279" mass="31245" checksum="818FA2FEB411F690" modified="2013-03-06" version="1">MIIEKEKKNEEVKAESCNENIEGKAVDKEGDGKAVGEEVKAESCNEKIEGKTVDKEGTGKTVGEEGTGKTNNDKTVGEENDGKTVDKEGPTTNGNKNIKPESMSTSSIFDRPAQPVHKESEFLKERGKPLFIEKECSDVLNKTSSAINTEQDKNIHFKATCQLFMFSENTGAIEQRGDGIIYIKMVEKHKLYKLTMVRDRIYKLGCNHFILPIGKLHAHKTSANTFIWHTKNDKCDDDVKSEKRTFVVKFGCGEDAERFESKYGYAMGENAKVLSDMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0L4</accession>
    <name>L7K0L4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0L4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0076"/>
    <dbReference type="HOGENOM" id="CLU_2203402_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0L4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="13111" checksum="242683A62E436D4D" modified="2013-03-06" version="1" fragment="single">VAKQENVRKSINRYTDTHFNLARIGCIVETLFYYMARRLIIEENPERWSNEMITNANQFHTYFHELVFRYYKAFSHNKLCPFDEDGLEKLDHTLQQFEHEYEAEKDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0M1</accession>
    <name>L7K0M1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993799">
        <property type="protein sequence ID" value="ELQ76972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0M1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0035"/>
    <dbReference type="HOGENOM" id="CLU_2706552_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0M1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="8845" checksum="04C60E0BC2A72864" modified="2013-03-06" version="1">MTKHIYNKRLDINTRKIENEKRDEIHKSNSELENGKNTNNRREENIIMKYLDDKKSSKEYYKLLITTESLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0M3</accession>
    <name>L7K0M3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0M3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0009"/>
    <dbReference type="HOGENOM" id="CLU_2484913_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0M3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="87" mass="10285" checksum="9F4DA0CE9021C5BB" modified="2013-03-06" version="1">MEDLRITYERSKTKESVTNDMKRVSSFFANTCNNQVFDYAFEKFVDFNSSKISYKCLLACIGRMQKKAAYKCNVERCNDDIYDKFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQX2</accession>
    <name>L7JQX2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3209"/>
    <dbReference type="HOGENOM" id="CLU_643358_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQX2"/>
    <dbReference type="OMA" id="QCHTNID"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="427" mass="48114" checksum="EB05A5A71BC9BCCE" modified="2013-03-06" version="1" fragment="single">MFLFTLYCVISCNCPKSEETGESSGSEAVINQQNVKEHNCLNTVGRRLSNPSHKLHIPTPSQVHALKSCEHGINKSDDEGYSSDMLSPANLDAGSRLTPSEPSPILPNVYNTCRSGTQQKSLDYFSLRRNGIACDDNQTFHSDGSEADYKMTSAKHRKRSMHDTSNNIDKPLIVLTNGESMSKKKFDQGNGKTKNEEQKIDKRIEAEPDNDFMNRESINQDVTGTSNSTSTDSITSNLSSIKMRIAELKRTFESYLSTDSYENMVKTQKTPETPENPQYSSSNGEFIPIPEPISLFDKNVLLVELLSYMETRLDYMKAFVAQIHSLEEINNPPFRKVENSKKAENVTTIACSKYVTITRKEVEGSKKVISEFENGVQNVCNMFITSYLKLSDVLLQIRKKEIKFENDQVKQLQHENDPLNGMLGINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR63</accession>
    <name>L7JR63_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3103"/>
    <dbReference type="HOGENOM" id="CLU_1504502_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR63"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="179" mass="20411" checksum="7E44960F148CB20C" modified="2013-03-06" version="1">MENTTMHRNQHTEILTSKSDTEDKNEPANDFLPVEFSFSQFLEGFIFAAMIIVILGLLCLYIYNKCRMHNRCRFGSTNDSQATGLEDLVSIEQQELSPPLYDEMFTVYPLNNLIHENNGVSCHTESGMADNQSSCMVNYEYGGILLLYMFEPPPFYDDVVILPSYDSTEASPLPEYSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR67</accession>
    <name>L7JR67_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3108"/>
    <dbReference type="HOGENOM" id="CLU_3360014_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR67"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4147" checksum="7A7C17C7E420A0B9" modified="2013-03-06" version="1">MVDCSFPGKALFVPYMRLTDAYQNVLSTVERVPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRD0</accession>
    <name>L7JRD0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3210"/>
    <dbReference type="HOGENOM" id="CLU_2851321_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRD0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7757" checksum="4EAE3559D3202E53" modified="2013-03-06" version="1">MEILRRVRESNRQINTLKEYVKKLKYLNSLKENSVLPEEEEVSLFAQIQALNDLFKNLSDQVKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRH2</accession>
    <name>L7JRH2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3197"/>
    <dbReference type="HOGENOM" id="CLU_2559920_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRH2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="82" mass="9009" checksum="8423D62937821F0B" modified="2013-03-06" version="1">MVSVLGDTNDIKYRKTVLPIQDGEEAYYAGTCRFKRSKSDTLACHQAVNSVEKTLLPAKISALRTSGLPTRPVVCKKVGNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRN0</accession>
    <name>L7JRN0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major Facilitator Superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_3146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRN0"/>
    <dbReference type="FunCoup" id="L7JRN0">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3146"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_14_1"/>
    <dbReference type="InParanoid" id="L7JRN0"/>
    <dbReference type="OMA" id="SEPQWRA"/>
    <dbReference type="OrthoDB" id="2196240at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="27"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ73950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="408" mass="45969" checksum="A19EE391AF1DADE6" modified="2013-03-06" version="1">MTESVPLKYDQSDDDVEITSHVNENIFTNFSVLTAYVCGLSFGFHLTALEIIKKLYFTGNALHTLKEYYVLASLLFISPLISSMLYNHINMKLNLWIGLVLLLHSISAIGLMMPYILVLYAFRCVAGVAVGLSTAVVPQYVSRLKKHRRGFFTFLFQVSILTGILIGQILSYYTSTVFLFRIIFAVFSFFNVMFAGMSFFIQKPAETETRRESRGITSLLAHKRHIKSVLLALCIHIGQQMTGINGIIVYSNTLLEENPGNPQMRTIFIGLFSLVVTLVSAAFVDVFGRKFLLLFSSTIVGASLILLTTKKYVLASVLAFQFGYSVGLGPITWLLTNELFPLNYLQAANSICVTTNWLCAFLVVIGFEYSYLRVGNALLWFYVCCMAVFTAIFFFYYNETKGKEPNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRN5</accession>
    <name>L7JRN5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_3151</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRN5"/>
    <dbReference type="FunCoup" id="L7JRN5">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3151"/>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="InParanoid" id="L7JRN5"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23276">
        <property type="entry name" value="beta-trefoil_MIR_PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="446"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ73955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="712" mass="83270" checksum="F9754208B8B1C6B8" modified="2013-03-06" version="1">MDKTPTNSSEEVNEQVEEEKNIIKQRIGGTTSICSEVNEKLNTKNKSSKGRIGEKSELFLLCLIFLVSFLVRSYKIEKGNFVIWDEAHFGKFASKYLQRLFYFDVHPPLGKMLTALSGYMFGQDVNFKFDSGTSYPAQMDYVGMRRFHAFISSFVPVFSYLTLREMSFDVHCCSVIAFMIIFENSLVCISRLILLDSHLLFFTSMVMYALAKYIRKRTIPNLVLLGTALGCVQSVKWIGCFTTFLVGIFIIAELWLLLIQKDVAITRFARLFTERALFLIILPIIIYLAFFLIHFGIVNRSSPDDGHMSSFFQSTLKGNEHKFRKYVEYGTIVTVKSNKLSGQYLHSHKDEYPENEGCQMTTYGHKDENNYWAFQKVVDGDTKVEMVKNNDEVVIMHMNTFRYLNLVDKDAYVTKEDRLLSTSPNTELFRSNLFKVEVVDDMITKEDKIKTLTTRFRLKSVDENCYVRSTNKRYPQWGFRQGEVTCSRKKDSSTLWNIEMNNKVKDEDLEYKELSNLKTAVFYNIVEHNALMYITNKSFVQDDDLEPIRIVSQAYEWPILRRGLRMCSWSDENVKFYMFGNPFSWYLSLACVLAAPTVLLCKTLTQIRNRQRIDARMLIFCCLFCGGWAIHFLPFFFIGRVLYFHHYLPAMYFSMHTLLVFVRNHKLLYTILFIQIIAFVLYSPLTYGFYDQNVMRWLKLLPTWDFVDDIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS35</accession>
    <name>L7JS35_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-type ATPase (P-ATPase) Superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_2789</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS35"/>
    <dbReference type="FunCoup" id="L7JS35">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2789"/>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="InParanoid" id="L7JS35"/>
    <dbReference type="OMA" id="CFVLWFG"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="13">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="11">
        <location>
            <begin position="173"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="12">
        <location>
            <begin position="861"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="497"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ74283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="936" mass="104681" checksum="2AB27C2303FEEA3A" modified="2013-03-06" version="1">MSNTYNFLKIDAETFCTIAESGDITCDDKFKNIEDVGIALHRDLHTGALLEIGEIAQLNDNERADHARKKQIYAQESKRMYGVNEIVVDDPRSITCILRKNMRDRILILLFIASAVSLIVGIYNTLYENEPYSYIEGLSILLAVVIIVAVSTATEYTQEQLFKSLESKKADLSVKYVEDGVFNTKKISEILVGDMLYVEPGDILPADAVLVSNDTLFVDESMLTGESNTMEKNMHMPVLRAGSYVQEGAARCLVIAVGYNSTKGKLLRSMVRPARKTALEKKSEQLANQLATRALIVCFLFFCLHIVKIYVLEGPYTLTYVVRKVIETIALAVMIIPEGLPMATTMALSFGTKRMLKDNNLVRDIAACERMNNVRYLCTDKTGTLTYNRLRLRNAYVKRKSLANASLVKSIFDVNDADNYRYIVHNIVFNSSAFKNREGVYVGSRLESTLLALLVKTGVDVSVMRKKSHVLRRLCFSSERKYMATIIEDVGVEMGDRPSQRCADGASSNDNEYNECSARSSTDQSTICTDTHSNADPGTGPNTVSPVDSNKNRGTDLNTDHNTVPTVDLSAHIGMQISTANDTNETHKKEQKKRQYVALLKGATEQIVKYCQYEIIDGNKVEIDRLKITKYLKKQDKLCKRTIAMAYAHVLGYESTFVQIDQLPGLVFLGCFSFEDPLREGIDQKIEVMKDAGLNIVMLTGDGLESASYIAEEIGILDGKYEAITGKCFKSMSDDELMNRIENIRVIARATPIDKQRFVDILQRKGETVAVTGDGANDGPALKLADVGFSMGMSSTDIAKEASSVVVLDENFESIIRAIAWGRCINDSIRKFLQLQLTVTVCTVVLMAVSSLFTFEQRGLFTPLQLLWINLYMDAFSAISLSTDKPTAVHLSRKPEHPDNPLITRYMKHFVFFSTLYILMVTLFMYYTSFGQFLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSD8</accession>
    <name>L7JSD8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2696"/>
    <dbReference type="HOGENOM" id="CLU_3418545_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSD8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="26" mass="3289" checksum="0EAF0ACB058F1436" modified="2013-03-06" version="1" fragment="single">VKFRIARYYAQSKRFFWNVHKQQMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSI1</accession>
    <name>L7JSI1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Flap endonuclease 1</fullName>
            <shortName evidence="16">FEN-1</shortName>
            <ecNumber evidence="16">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">THOM_2623</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13 16">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PCNA1 and PCNA2. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="16">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="16"/>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSI1"/>
    <dbReference type="FunCoup" id="L7JSI1">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2623"/>
    <dbReference type="HOGENOM" id="CLU_032444_2_0_1"/>
    <dbReference type="InParanoid" id="L7JSI1"/>
    <dbReference type="OMA" id="MGIPWVQ"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 16 20" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 16 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="19">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="18">
        <location>
            <begin position="143"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ELQ74443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="39046" checksum="625DF1BD0C692D6F" modified="2013-03-06" version="1">MGIHNLTKVIKKYYRPAEHPLSFYRTKKMAFDASLLTYQYLVAIRSDGAQLAHNSSSTSHISGFFYKIINLAEIGIKPLFVFDGKPPQVKSEEIARRNERRKDAAEKYSEAEEQMDKVKMEKYDKRKLKIGKEHTDDIKSLLDAMGVAYTISENEAEAFCAALCRKGIVDYVCTEDMDALCFRAPVLLKNFVKDSVAEYRLDEILRDMKLEFDEFVDLCILLGCDYAGTIKGIGPMKAETLIRKHRSIENIVKELQVTDYEYEKARETFLNMKNNVEVGFVGIDWQKYDRNKVFEFLKEKNFDERRINNGLDRYEKCRNKKEQSRLSDMFKKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT11</accession>
    <name>L7JT11_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine rich repeat protein</fullName>
            <ecNumber evidence="3">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.3.2.19" evidence="3"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT11"/>
    <dbReference type="STRING" id="72359.L7JT11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2481"/>
    <dbReference type="HOGENOM" id="CLU_1116414_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT11"/>
    <dbReference type="OMA" id="INIAHNR"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="249" mass="29161" checksum="E61B645775A304D5" modified="2013-03-06" version="1">MLVCLPRDIGKLKNLESLDVSDNRLKELPDTFSALQSLTVLNLTNNRFDEVPRIIGCIRTLHILSLEGNAINDVPVEVIRLPYLSVLKTRPLAPKSSIEVRSSGTSIDIAEKTARRVIIKHLYKKCKLNVHVKRLLMQVKECSFCNGPYFRVNYTVITNQFYNSRYIPVRHEMCSLHFTSEPTMFYLLYMRPNYQGILPRDSEERLPFSMIFNYHAYGDKFKKYIDEQNEEEGTILSLIYHYKRRCDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT31</accession>
    <name>L7JT31_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spliceosomal protein FBP11/Splicing factor PRP40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2570"/>
    <dbReference type="HOGENOM" id="CLU_1078434_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT31"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="258" mass="30779" checksum="66B3892C9660ED11" modified="2013-03-06" version="1">MSNESENTCQEVKNENPYKIYHTNTGKLFYYNTNTNKSYWIVPKNDRKYFSSGNLQTISTLGNYLRLDKKDKKLFFELLEQCNMEESATMEDFDKKLGENILYNAYGDVKDAFLNEFLKLRREKIAREENRKCELTMIQLLRKYLYSDYDPSYDYKAAVNFLAYNNYYWNAEKRREFYTNFLVNRFIHYHMLKGVEKNEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXWQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT34</accession>
    <name>L7JT34_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2421"/>
    <dbReference type="HOGENOM" id="CLU_080517_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT34"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="301" mass="35830" checksum="F4C6B79421214AFA" modified="2013-03-06" version="1">MRKYIFWCQIIHQMRYDEDLENRVEKLCFNLHAVENKTEPTGLYTSNPCFYDLMQEIQNIAYYHVLEDKQGSILLTSETEKYERLSPMFISFKDFQNIFVPNFLKMDSKFLVANREYIEGLCAHFSENGTNRIVVDVDFSGICNGRTDWEYLCYDIKNEKDVMAITSDFLKSSFIERLIIRLKKVNCDFSIPFPMNVELYFDRCNINEKIDFPSKLTKISIIDSAVYTSLNMPKTLKTFVLRRTMVWECYRVDINSDCMSITIDRAMGNINIPYIPNSNPFDLRDIIWSFERQKKRKWINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT42</accession>
    <name>L7JT42_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT42"/>
    <dbReference type="FunCoup" id="L7JT42">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2893"/>
    <dbReference type="HOGENOM" id="CLU_000288_59_8_1"/>
    <dbReference type="InParanoid" id="L7JT42"/>
    <dbReference type="OMA" id="DICHLYL"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="405" mass="46451" checksum="0237EFCDBCA24AA8" modified="2013-03-06" version="1">MDKYTLGNIIAQGTTCVVREAVDILGNKYAIKIVCRSARKYKDIKKEMMIHQHLQHSNIVKFKELLIATDYFIVMERVAYELFVYIEPKVGMPRMLVHLFFVQLISAIEYMHDKGICHRDIKPENILLSAAGNLFVTDFGSATLFRYKGRIRILNTICGSLPYIAPEVHKGAYNGAIADIWSCGIVLFVMATGILPWSRGDQTDIDLANYTKLKYHNYEPFSRLPRDVKHVFDGMCRVKVLERFTFGAIKQSSFFVQPNELLGTDGLCTDSAKLFSFFKTKNELVLPFSQPNQHLISLNTTNFVCSQPNGNDSVSLRRVYLSVEEEKIMNQLILVLDHFNVQFKRKMFALFFSTLDTYRNVLNGEFVVKRINNMCVISINRVKGSTLEFKEFCNVILGHLKSKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT58</accession>
    <name>L7JT58_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2857"/>
    <dbReference type="HOGENOM" id="CLU_678261_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT58"/>
    <dbReference type="OMA" id="IVYAWLR"/>
    <dbReference type="OrthoDB" id="10350542at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="409" mass="49028" checksum="DA2A448D4A3BFD64" modified="2013-03-06" version="1">MQRFLELNLDLEKYYQLARDITNKRINNYTALQYYKTEEDIKYLFKINSLKVFGEVKGTLQMLVESAGEDEKQIIDFLLRRKRTYKSALLVILCILSFKFVIHARGRKNRKKNTSSYKFKFETNEEAFLYYLYIVNNVDKRYISILNKKIRQLPLRMAFIAAYLLKCDELMKQVLDRWHEDYKVPQYVFEVYEPSYEYISTKMITLPNRDLLNILRIVNIDRIRIVKSFLNECMKQFMVTNDEKLLNRNLSFNEICLEVSMSENVFKYPDENSFICQKERKETKKATADEVERRTNHTDVYDEVGECASKEHHLKCSNIQIMKKIVYAWLRFLLITNNYLLFMDMFEKLREDSCPEYKVLKEIHNRITNVLKGQPPNFSDILSSYHENNEFSLVSLQDLGEYLCKIRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTC5</accession>
    <name>L7JTC5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2349"/>
    <dbReference type="HOGENOM" id="CLU_3362243_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTC5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4112" checksum="91A049434BF05DA8" modified="2013-03-06" version="1" fragment="single">VKKCEVLIKRTLKQKNDYLGPVAIVGLETRNVCLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTE2</accession>
    <name>L7JTE2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
            <ecNumber evidence="6">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.19" evidence="6"/>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTE2"/>
    <dbReference type="FunCoup" id="L7JTE2">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3060"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="InParanoid" id="L7JTE2"/>
    <dbReference type="OMA" id="MMYCHAI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990305">
        <property type="term" value="C:RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990303">
        <property type="term" value="C:UBR1-RAD6 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042275">
        <property type="term" value="P:error-free postreplication DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000639">
        <property type="term" value="P:negative regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090089">
        <property type="term" value="P:regulation of dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="48"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="206" mass="23665" checksum="76C804901180DC32" modified="2013-03-06" version="1" fragment="single">VSCHSNQCLLCSSTYSNSVQPDLLPSHVTHFISFFYIPRHFIPPMSTPTKRRLMKDLKDLENTKNRTVFAAPLQDDILTWCALIIGPKDTPFEDATFSMTMSFDESYPCTPPTCKFISKVYHPNIYANGDLCLDILTNRWSPTFNVMTVLMSVQSMLNDPNVQSPANLEAANLFDNDRKCYVRRVRDCVEKSWYDLDSEIEKNEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTG0</accession>
    <name>L7JTG0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2309"/>
    <dbReference type="HOGENOM" id="CLU_683675_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTG0"/>
    <dbReference type="OMA" id="RINMENG"/>
    <dbReference type="OrthoDB" id="10560634at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="403" mass="45479" checksum="500235AE3CB13618" modified="2013-03-06" version="1">MAQLAIVKTRIGNKYEGTFKSYDRLQGTIVLEDVRMFEHDTNTRENAVCVNADHRVFSFIVFKLNSLTYLEIGGIQINTNMFVETERCVVGMDLGKGVGDVIVGGGELKNRLGLDGDEEMVVVGGGELKNRLGLKSKMRLDEESERGYSGLEGSNGVMIESDYIGIEDVSSVRGVDGESGIDASEHGIGMPDKNNQTKIKKLKERLQNKDKNKEMVRNLDEDFRIADTPKTAGGRKIRDDACGGFPDDKNGSFNLSFTDNVLVVMNNDDKEEDSSDYRKRSTRYEGFCCKESSSGERYLTERNQRNGPQSRYYARSHETGSSVNEHNYESYFMNHSEGKPRTKYPKKTSKYDKKKPYQQEDYGLKGNVPKSDFDFANTDSIDKIDTELEKSVESSKKSFFDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTI3</accession>
    <name>L7JTI3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2418"/>
    <dbReference type="HOGENOM" id="CLU_158828_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTI3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="131" mass="15474" checksum="35029C4556BDC388" modified="2013-03-06" version="1">MDMNPYFNMKDLRNYGGLKNLALDNRILQADDFFDNLPVHLQSLKFVLYVADILLKPIQNFEKICLKSFTIKFIKDPEVKSLIKDPMEVYDIRISMLSQFACFIEFKKLAELKFELNGESMFLDTEIYEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTQ0</accession>
    <name>L7JTQ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTQ0"/>
    <dbReference type="STRING" id="72359.L7JTQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2214"/>
    <dbReference type="HOGENOM" id="CLU_133427_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTQ0"/>
    <dbReference type="OMA" id="VPECYEY"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="171" mass="19689" checksum="FB6F99230891258E" modified="2013-03-06" version="1">MFCLECVSLLFKHLQSTAIKTLTLNSFIYSPSHTITQSKSFYLPEPLMEVYKHVYTVETIDKDKKIFNKLSKLYLADQAYKLTIDYHSLLFKPKINDKIEIVIYKGILAEEEVPECYEYVLQGHCYRNKLADGKRIIGVSFGGMLMEMIVDENDVNLASNCQDVGMALRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTQ1</accession>
    <name>L7JTQ1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994072">
        <property type="protein sequence ID" value="ELQ74132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTQ1"/>
    <dbReference type="FunCoup" id="L7JTQ1">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2960"/>
    <dbReference type="HOGENOM" id="CLU_163495_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTQ1"/>
    <dbReference type="OMA" id="SIPTHKK"/>
    <dbReference type="OrthoDB" id="2189967at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="132" mass="16139" checksum="B05B079E2C172DD1" modified="2013-03-06" version="1" fragment="single">NHNTHKLSMSKDNGHILEISIPTHKKLNNIIHYEILCITNLQEYRKCYSRVFRRYKQFRHLYKILSGKIVQPEFPKKRFFNYKEEVIKERMAMLGVWLRYVAKLIDDNNCYRDEWAKEVLRFLQDDKYPGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTV7</accession>
    <name>L7JTV7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_2586</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTV7"/>
    <dbReference type="STRING" id="72359.L7JTV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2586"/>
    <dbReference type="HOGENOM" id="CLU_1416171_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTV7"/>
    <dbReference type="OMA" id="KCKFIRR"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="12">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ74491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="201" mass="23538" checksum="3241E9207798C851" modified="2013-03-06" version="1">MDEPFVKPVKTYKDKSDRATRDKVLDRKTLVILEKLQKRNILFDLEGCISSGKEANIYRAKIRCMPKCKFIRRSDSTENFHDKAGDTQNNNSELPVAAEDVVIKIFRTSILEFKNRNVYITNEIRFKNFRISNPRKLIKTWAEKEVRNLTRLNNSGIPSPQPLYLKRNIIIMRLIGDDVHVAAKLKDLQNVHFYPKFITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTV8</accession>
    <name>L7JTV8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2338"/>
    <dbReference type="HOGENOM" id="CLU_1983125_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTV8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="126" mass="15070" checksum="EDFD98B8075AB9C6" modified="2013-03-06" version="1">MEFLSGSMRFLLIQEANTDWLKKLENGVQNYSILIHEIFERLYKAHCGDKECPFDDDAVNSLSLLSDQFATEFENEGAFWSKQRIKLKNYIYVYDECMLETWEKLYKKGITDRINIYINRKQVLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU09</accession>
    <name>L7JU09_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3</fullName>
            <ecNumber evidence="3">3.1.13.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="3"/>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU09"/>
    <dbReference type="FunCoup" id="L7JU09">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2868"/>
    <dbReference type="HOGENOM" id="CLU_002333_5_0_1"/>
    <dbReference type="InParanoid" id="L7JU09"/>
    <dbReference type="OMA" id="IASRECN"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="411"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="834" mass="96366" checksum="FBDD61B2910072CA" modified="2013-03-06" version="1" fragment="single">VCPGMITYDQAYAFNRKHKLIKRVVECYKRADIPCGFACCGNAKLTNTKYYIPDADTLVKHKSLLFSENIIVLQSVLKEIKQKNVGTYNSYTRIIKRNNIFVFYDDFRLEEINEEQERTVLEGYNEMRVYEQKWPEKTARALSFYNSHVRGVIFSVLNRQTCLESADDPVIRDFIAVQDTQDDENYREYTNEGCVGFFHSSYYNYFSGTIYCGNTKYYVNNRLDVNRALNGDEVFFKTVESDDVTAEVLETDVNAGITQETGTIDTKKEKKVFAYVTGIKQRKDKIIIGTILNGTISGVGTQNVLVKPIDKKYPPCRIQTSNVERYKNMRLKIVISEWKETSKYPNAVYIGMLGPVGDVQTEINSILILNEISDTPLNQNYYEETEKFGHEQLNCEETRDMQHCMHINSDRLDLRNEDVFSIDPPGCTDIDDALHCKIGTTTEIGVHIADVSSYVPRNTAVDEEAKRRGTTVYLNDRRIDMLPEVLSSDLCSLKSNVDRLALSVIFQFDADFNIIGSKVCETIVKSREAFTYDQAQNILDCDKDHVLYAPLRRLYDVSRKLRKSRIDNGALILNSKEIFVRRNRNGKEIKGRCTQENEIHRANGDVNLSIDDKSEVETCSVIEEFMILANVTVAKFMYEHIKNCSLLRRHPEVEMKEIESEIESVRSMLKRRSMAQATYFSSGTVAFADFKHFGLAEPIYTHFTSPIRRYADLVVHRLVKSVLFRTDYGYDDYSIDALTKHLNVKHRSAQIASRECNFMFLYFYLRERECVTQAYVIKSLANGSIVYVPEYDLDGFIKSVRTVNEEVKVRIVRDDENFFINRWIKLEEVVQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU27</accession>
    <name>L7JU27_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU27"/>
    <dbReference type="STRING" id="72359.L7JU27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2282"/>
    <dbReference type="HOGENOM" id="CLU_1202378_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU27"/>
    <dbReference type="OrthoDB" id="2195485at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="231" mass="27766" checksum="847F3A67B683D819" modified="2013-03-06" version="1" fragment="single">VEELCTKGICVNTFILSDEILVKRAWIDSRSKDSTNLRNIFHMLNKHYKTDLVYDCDNDDKLITFLRHVFLYCYYCARVFDTEIEMIRKCGDYHVRDGRVQRRVFDRKQKIITMERNFNYLKTDSPETELEKYVVRLADGVFRCDLCHKTFEQLVYVKKHIKNKHEELYSDVEQEIERFNCFLDMIDINLLNYFDGIDNNYLPTFCVYEEEGNAVKYDLKRLFSGDIKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU42</accession>
    <name>L7JU42_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2479"/>
    <dbReference type="HOGENOM" id="CLU_1972018_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU42"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="127" mass="14724" checksum="BECCA842B011CC86" modified="2013-03-06" version="1">MEKKNEDSDAGASEYFSAVTSKNEESSNHEQQVDLHLKPIISDDKPFTCKRQIRSYPERIVSNEELSNHEQQIGTYPERIVSDDESTIYQSCSCARDVDDLDTTSDEVWFDAKDHIEDPMKHRWIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU85</accession>
    <name>L7JU85_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2520"/>
    <dbReference type="HOGENOM" id="CLU_3038213_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU85"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="6232" checksum="B0AE184CF9BD787C" modified="2013-03-06" version="1" fragment="single">VEMECKMNTEEVLEARRDQGLTTSGHHEELEQEETEEILTGQDVHDVPSKGGMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUF1</accession>
    <name>L7JUF1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">20S proteasome, regulatory subunit alpha type PSMA5/PUP2</fullName>
            <ecNumber evidence="2">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="2"/>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUF1"/>
    <dbReference type="FunCoup" id="L7JUF1">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1942"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="InParanoid" id="L7JUF1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="17687" checksum="F4B27B348FF72E2D" modified="2013-03-06" version="1" fragment="single">VIVEKSRMYMMGRMMQYDECSSVVGILKRLCAQSLKFGERDPNKKIFSRPFGVSILIAAFEDAPKLYLLEPSGSYKQFRAKSIGSAYQAVDNELLERYDEQMSHDDTVRLSYTLLKEVMRDKISKENVETMVVDKDGVRFLSEDEISNYLVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUF6</accession>
    <name>L7JUF6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1947"/>
    <dbReference type="HOGENOM" id="CLU_906692_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUF6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979037" evidence="2">
        <location>
            <begin position="18"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="307" mass="35485" checksum="472F25D927538669" modified="2013-03-06" version="1">MMLNVLPFISFLRFTLQTNDDTCKDVINTKFNMREAKESTCNNKISETDANIPNCEAEKCECGYKQQPIDSLVEFPFHLVSKCVLEDERALSMTKKLQKSFNSRVAEYCTEVFSECNRRLSGAYQRFTSWTEDLNTLRRKGLKELLKSFIKACAKGSRTLLQAPTKCTDYSWRGRTKMPIHGAESSSKKDKCIQAEENDIKTTLQQDSEDGSFTYNYEEAYPPWWYEQLKNAMEDSMYNPIGIGTNKKVDDQKTCENVKAESTEEENTKKNMNTYTKFKVAAGIFLVVFCCLLMVYIGYGIYSRWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUJ9</accession>
    <name>L7JUJ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding Cassette (ABC) Superfamily</fullName>
            <ecNumber evidence="12">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.44" evidence="12"/>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUJ9"/>
    <dbReference type="FunCoup" id="L7JUJ9">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2378"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="L7JUJ9"/>
    <dbReference type="OMA" id="IVFTMSH"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="68"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="341"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="593" mass="68317" checksum="1926D55AB0E524D7" modified="2013-03-06" version="1">MASITTYEILQIIMTKYVKDIPLIRMTIMPTLFLMFVARIMEVKVSEIVQNASLEFSGYREGGTFKKYMIVGILSSLLIELQGFIFKSSVQRAYRTALKSSLREYLLLNWSEFKMKGMGEITASIERRSSAVSEILDVFIINLLPVFFVLFLAVLKIYAIMGFTSSLIILISLITYTTVTIKMAVWRNEIRKKLNLSINESNNKLIDILSNYESILAFNNQNLELYKYDNKLATSEKHYVKLWRTFYLLNFLQRFVLCVQTGMIIYVGMCNKITSDQFVLYLSISKILASNLDKLGYMYSRFTAAILNAKMSFLDTVLPKKLYPIRYFDKKIVFRNVALPLSSENILNTSNDVFTYAISDNYIFKNMSFEIKKGEKIALIGPNGIGKSNFLKMLLKFNEYTGSIKIDDDELCTIDNYSLRDLISYVPQNSYLVSGTVKENIKYGNLVATDEEMIELCRSLNFHESFVRLSSGYETCIGENNSVLSGGEKQKVAIARAMLKNAEIYLFDEPTANLDKKSEETFFKRLAEDTQNKTVIVILHNLELLDYFDRIMFLQKDRIQEIKREEALKLMNSTKNEKSTKNAQEMCDTSEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUP3</accession>
    <name>L7JUP3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative WD40/YVTN repeat-like-containing domain, WD40 repeat-like-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUP3"/>
    <dbReference type="STRING" id="72359.L7JUP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1905"/>
    <dbReference type="HOGENOM" id="CLU_357219_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUP3"/>
    <dbReference type="OMA" id="MVICALE"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="785" mass="90517" checksum="73A9C745E8C98360" modified="2013-03-06" version="1">MLLTSRYLSSLTHEYIALGTKSKLFDPTFSNYSELIIINLKTNEKIKREMNGRFNDILVIENMVICALEQEMVIYRVVSMDDEQLDEVDNSKNTRCLECVLSIKMVVNALSFSQKRNMLLLAADKLILLDLNTVKSYNVGITGRANSISYNKKVNHIIAASIDNQLLVYDIKKKEEVVDKKFSNLKRVEWHPHTSMYLFIQEDGLSVLDLSNDKITTICLECTGFLVRDEFLYIWDQSCLRMFRHGESAKVQNVKTDLLIHVGDYAVSDLFHFNTNDRLAVISLLSGSTMILANSFLFYSSPPFSFALRNNVIFYTRDKEILRKQIHLMPIKVEKDVHELLAGVNNGAEYECPKLCVQDDEIAQLILEKRWDEIKCRHDAVDVPLAYFLDEDKKFLMDNLKLLLLICVKESNYRFLIENNVVDYKYLLKYLNKEELGVLAKQLAGKVPFDEIARIYEMAGDKKMLFKIKFDCIRKLADQMSICDVHGVYLNLIHKMKEEDVYFEDEMIDYFLEYARFVNDKDVVEYLEDKKGMKRTNEMNDVKSRATVVEQRASTVKLDRSESTENVLPRPAPKSSVPEIPLPQRVSSTPIKTHPPTGPALRKSPIIPGMQDMPDISRLSLNTKDKKLKYSDIMKGRTAPQSGFRPVTSEKKAVKPPSLSIPKPVRSENIANEPPSVTQIKNISEEFNEDEINELDSLIQKRIADLREKSAKKKGIIFKARIKDGLQRVGHYKKITNPNILPYLRIFKEEGLSYEEFLKKSQALLNFSEVKMWLEGILNLWKIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUT2</accession>
    <name>L7JUT2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993994">
        <property type="protein sequence ID" value="ELQ75080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1976"/>
    <dbReference type="HOGENOM" id="CLU_2943464_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUT2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="6966" checksum="913453250B3363A4" modified="2013-03-06" version="1">MRDCQELNTCENPREEESLRILLRGPHASHDLRVKVTVAVVAYLSFVVVMRAKLFREMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUU8</accession>
    <name>L7JUU8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994021">
        <property type="protein sequence ID" value="ELQ74816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2248"/>
    <dbReference type="HOGENOM" id="CLU_617039_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUU8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979165" evidence="2">
        <location>
            <begin position="25"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="444" mass="52830" checksum="F0D2E34C9F2D3537" modified="2013-03-06" version="1">MVAREMIKAMILSLFMYLSNILSAFNSPRKANVAYNVQKSDQNNDFISQLKFYNDAELRNENSINAKFENKIITILPDIKKILSALRYHEFIVDLHHSEAVRFRGFGMKLDHNCAAVIVDLMIPFIMLKDKKQEIDEVCKDLECFIRDLKANFEKIRNQNAEKLSYSEREFEIIVEKYGKEIKNGTFNWDAFVYSHYDHVSSIIICNINRNKVEHIRFCTQLALLLRITVAKNFLSFITTKIAKYNEKDMWRTTYIWFGSQIRSDQAQKIMDAANAENKKLLCYEVLDRFYDSVYEIMYSFDSKSNFMIKAFRRWRDGKAKYSYTSDLNQKTDLEHFFGFIHIYNSKNLKYLYDQRVKSYTDQYKIAGAAIDREVKDKIEEINKKDENKLQQYTNERNALVKKLVAQKAKAQDLQKQIEEKRKEIQGCYPRQRIFRYKSRYNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV13</accession>
    <name>L7JV13_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2188"/>
    <dbReference type="HOGENOM" id="CLU_1062400_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV13"/>
    <dbReference type="OrthoDB" id="10593774at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="262" mass="30197" checksum="A25E350B1A9F87CB" modified="2013-03-06" version="1">MVMGQKKKKKNENEHGIEEKDDLKAMKSKNRNNKTSGEGKMKQIEENNKIKKHTEKVTKTKKNKEIEVNEKTKRVKKSKRVENDRSDKNDQPIDQLTKNENSEVIDNTPHVKETNSKGNDDQSLEIVSKIYERLWKKYQHGNQRVYVKGFTAEQIMYQMKELIDYVIEEVEQKADEYEQEGAYVEGDNDDVCSNSGDSTSDNSAMNASSSDEDQSADENDELITQQVNSYQTSLDVLKALDATTRSEYELDEEVESDYGEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV85</accession>
    <name>L7JV85_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1725"/>
    <dbReference type="HOGENOM" id="CLU_2943461_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV85"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="7199" checksum="E1D3BF30B21BEB6B" modified="2013-03-06" version="1">MELDYYFYPDEYLDYDLGDLSIPVSIFFDTCDDELDDYPLPHTKNEKFKLDFGISNFNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVA5</accession>
    <name>L7JVA5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994032">
        <property type="protein sequence ID" value="ELQ74662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2413"/>
    <dbReference type="HOGENOM" id="CLU_2135281_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVA5"/>
    <dbReference type="OMA" id="LICKIFV"/>
    <dbReference type="OrthoDB" id="10442186at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="113" mass="13418" checksum="2C6FB787A9D4D170" modified="2013-03-06" version="1">MFFEIGDTNLFSLLQKDKKGISHAKSILLTQLSRSTDKKRREQLVRNFSDYVIGVGEQRCRKIDPFNFITLFKTNFKLICKIFVYGMLLLLFFLLAYDLFCSFWDSLTYILFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVB9</accession>
    <name>L7JVB9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HECT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVB9"/>
    <dbReference type="STRING" id="72359.L7JVB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1627"/>
    <dbReference type="HOGENOM" id="CLU_035440_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVB9"/>
    <dbReference type="OMA" id="TEHRMSH"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="519" mass="60499" checksum="F9778D44F8D06371" modified="2013-03-06" version="1" fragment="single">VRLSCPMILSITNAYIKDTSWKSFFATEKIALAITETNSRGENSTRTFSLKCRNCMLNYFHFFDEDNKLTLSMLKNGRLVHRMSVVDTSDRFSYADGGLKVLIELQLLNCDIFTYLENRERKRNGQPEIAQISKVIEVYSATEHRMSHDDRVYRVDKTNCCMSWQNTTIDQVSSCRGWEQIRTRKQLILWVNHGYQLVYLPGRTPVIVESEIERKTHAFYNALQRFETFKYLIFTKFALFTIRGFFVQSTASYFLRSEENMLRRNLHIKIKDEIGEDEGGIKNEFFNEVGLEIASDRRMLFTGSFLDVNRNVYDDGALSAGHGELSANGRENESTSERGGNSKTVERAFPYDRSALEVDVNAMKSLKEQMMRRLSFSKQPLIDTTATLRFWQSPEARNKKFIEDTDPAFYAEPNINTNLLSNDEFYAYLGTFLALCFLNREMISVKFSLAFWENLMGRKYTLRHVQDTQVQRNLLYVLREDLSEDFLDTFDDDLIRTDKQAICKENRVRIAVLLKEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVJ3</accession>
    <name>L7JVJ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1995"/>
    <dbReference type="HOGENOM" id="CLU_591307_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVJ3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="463" mass="53373" checksum="478A71ECD38E3D72" modified="2013-03-06" version="1" fragment="single">VMVQLPFTITFSGNCQNFIIENSKANIHITKAENVTISNCNELFAGKFRLELPLQLKELSIQETMFRHCWTVTNQIGNLRMYKVVFTYGSVFTLAHECKSIILSQCSGNFNFFGKMSLSVIQNNLYNSEFKVDLDNGNITNLSAFAILLEIDNSLLCKVRHFIMNFVEWKNMMLLVLNDDIVHFEVRQFYGVIRLSGIIQGKIMASGFEGNMRVAKLDNKPTYDVKITNWTVLGKLTINCLAQFLDLVKLSINNSTNELLILNRYNNLFINNIASSITIKFCPYLNNICLVRACFAYNDRIHRFIMVGVFIFDIYQLPPSIKTIIIQRCNINVGIQFYLNSEFNNLLIKQSSGVFHLRNKFNIDIITLNQESVVEIKEEDELSTELRFEHLTFEKSLIISENVKTLTLINVKFVDNSIVQIFSNDVQTNIKSNCEIHWYESNKLARIEKYGEDGVVCYINDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVK6</accession>
    <name>L7JVK6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVK6"/>
    <dbReference type="FunCoup" id="L7JVK6">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2296"/>
    <dbReference type="HOGENOM" id="CLU_075696_2_0_1"/>
    <dbReference type="InParanoid" id="L7JVK6"/>
    <dbReference type="OMA" id="IQKNHFR"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="168" mass="19762" checksum="6A7FF7EC2E5C5B37" modified="2013-03-06" version="1">MKHNNALVSNHFNKGSMKFKTWFDQPAKRQKRRAARREKAKKRYPIPVKKLLPVVRQPTQRHNYRVRLGRGFTEQEIVGAGIEVRYAMSIGVKVDKRRKDRNTETYERNVERLKEYLKHVKVYKNAKEAREDNAKSFIGTIMPVKNEKPVTKFVNVADINSYVEAFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVN9</accession>
    <name>L7JVN9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_1940</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVN9"/>
    <dbReference type="FunCoup" id="L7JVN9">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1940"/>
    <dbReference type="HOGENOM" id="CLU_863781_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVN9"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ75106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="322" mass="37850" checksum="030EBBCFD36C24FF" modified="2013-03-06" version="1">MLFKMVITMIFILFMLFSLFSIISLFSSSFSPSLTLHCFPYPLFILLFTPLLILLIPLLLITPLFILLFILLFILLLILLTHPTLHPTLHSTLHPTLHPTLHPTHPFLLTIHPLFYIRSLNRFLFTTFLHPPMLSYINLYNLAGTLVGAYALSSAVLNHFTKNVHFIFRIALCQSFYVLEILNILVNVSRARLFPTCVQLSSRLFIIWYICYRYNFTDAVVHIMLLCWFVSDTVRYVFYFSRRGTVKFLRYNLFIVLYPLGTLCEIVLVSRVERICTGVLKYFLRIVMLCYIPGFSFLYVHMIRRRRRTSKNKGVAQRKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVT3</accession>
    <name>L7JVT3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1608"/>
    <dbReference type="HOGENOM" id="CLU_3015873_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVT3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6950" checksum="3CEB674ECAAE070B" modified="2013-03-06" version="1">MDDEYEVFEAKHFLEKLRKKKIDDETQEKNRLNDKNNLVINRGIVSVMDYFKKYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVX6</accession>
    <name>L7JVX6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2153"/>
    <dbReference type="HOGENOM" id="CLU_1215531_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVX6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="228" mass="25772" checksum="98ED03481B52466B" modified="2013-03-06" version="1">MEELHPMRCTVEGIYVFTRDPSDSLLNFDLKDAQLDGELVIPNNIQKVRLVNVSEMQKFFITVNELCKTLLIENSTGIVICNSPMNLEKIVVSQSSLSALELRFSTSTEAMFDLNYEFEGGQNEQICVHIKNLCSLSFKHGCSNNIATIPKLMSDKTCDTSTLHLSESSYFAKDTKNAYDVDTANLNLITLLKGHLMIDITSSKRLNRKRLVQISITNSQHISQRRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW39</accession>
    <name>L7JW39_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW39"/>
    <dbReference type="FunCoup" id="L7JW39">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1335"/>
    <dbReference type="HOGENOM" id="CLU_015846_7_2_1"/>
    <dbReference type="InParanoid" id="L7JW39"/>
    <dbReference type="OMA" id="QPRANGC"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="109"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="483" mass="55206" checksum="4AD1DAB2EC2E902C" modified="2013-03-06" version="1">MGVNAESVPIFTMTTTYISFVLLILFGYMRDIVRMLFFTKGYEHLMRRGNLQPIYTAFESFFIRRLYTRIRDCWNRPITGVPGRIIQVLERKSYDNNQTFILTGKKIPLLNLSSYNYLGFGTNKMEVIKNDLATADLFPVNYPGTVSEIGTHPINRNLEKQIARFLRKEDCIVFPMGFGTNSCNIPIISDENTLILSDELNHMSIIFGSKMSQGCIRTFAHNDMDNLEKLLRFYISQGQPDTKKTWDKIIVIAEGLYSMEGTVLSLKKLIVLRRKYKFYLFIDEAHSIGAMGATGRGVAEYCNVPFDEIDIFMGTFTKSFGAAGGYIAADRKVINFLRNYSDFSLYGEQLSPVVAQHILTSFKIMNSPYGNVLRRRLRDNIAMLRKGLIAKGFVVFGEEESPIIPLLIYNPGKMFEFSRMCMQRGLAVVVVGYPATPVISNRARFCVSSIHTEEDIKYVLKVIEEVGELLGINVLKKRRFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW69</accession>
    <name>L7JW69_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW69"/>
    <dbReference type="STRING" id="72359.L7JW69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1375"/>
    <dbReference type="HOGENOM" id="CLU_128308_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW69"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="18073" checksum="37D07FD9D5D510BC" modified="2013-03-06" version="1">MSASKIFGNIKMKELLADSIIGILRLRNSQRHEFGLEKIRKTSLQKRVLQEVYKLTDFPSTNTREELALLLGLPHRSIQVWFQNKRQKNRQTSSISEKDSLINKENVHKVEQNTEYGSIATLDTYEISTCKLIEIIEFCQEEEKKKSYMFLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW77</accession>
    <name>L7JW77_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW77"/>
    <dbReference type="STRING" id="72359.L7JW77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2054"/>
    <dbReference type="HOGENOM" id="CLU_1595804_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW77"/>
    <dbReference type="OMA" id="IYALRHY"/>
    <dbReference type="OrthoDB" id="2188405at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="19737" checksum="2938080784971B9D" modified="2013-03-06" version="1">MSQTTSEKKVSNLIHSLFSAQMNDKVKNSLENIKIRMVQESEEETQAAMIIIMPIKVLDIIHQNFTLFRKNLANIFKNYNVFCVREPLYNKLSKSINKNVQEQWIFDLCYPAEVQCRMTEIKDGGKVLIEKVMLERKCDFLQEDFKIMENAYRTLTDKTVIYALRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW89</accession>
    <name>L7JW89_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993972">
        <property type="protein sequence ID" value="ELQ75316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1743"/>
    <dbReference type="HOGENOM" id="CLU_3074555_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW89"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="53" mass="6108" checksum="8E2B34ACD7FA41C1" modified="2013-03-06" version="1" fragment="single">VNIALELLRAIFGSQKSQMVNFLRIIQEVKRAMVEKHGRCKTIWLGMSYSGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWC6</accession>
    <name>L7JWC6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="4.1.1.65" evidence="4"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JWC6">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1381"/>
    <dbReference type="HOGENOM" id="CLU_529139_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWC6"/>
    <dbReference type="OMA" id="EYPNIEA"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="519" mass="58634" checksum="54D4E99EF47F7ABB" modified="2013-03-06" version="1">MTNREKNLEILYVDVPVVILSAKFCVASGQPCTLKIQTCIGDSAVNVGPSGEIKIFIRRNYKGPLNVQVYKSGLIIRKHLKTIEYPNIEAMILDFHHFSHPRVIKKVTMKLPSDMKIVVFTAENYLKNIKLAYKSRFFNVFTGLFLNNYQSAKIFVKTLSGTVVEEKMPTFLKIFLIYIYNDSLSSNIFYKTMCRKMTERAGRVYFEKKSVRYIKQFVQFFDIDLSEIEDEKYACFNDFFCRRLKPGARVVEDVRALCSPSDCRVIAFENVEESTKFWIKGTKFSLEAFLNGGTAYTTNKSREPTGCVDTGALADRDGNKDGRXXXXXXXXXXXXXSALADRDGNKDGHGALTDRDGNKDGRSNKTCQTYDQHKTSLGTLIICRLAAQDYHRFHSPVKGRIKMIKEINGDYLTVNPISVERSNVFTQNKRVVVLIESVQFGNVYAVAVGATMVGSIKISVTVGTEVDVMQEIGYFQMGGSTIVLVCERCLDIRKEVQINSNAQIETYVKVGNALAFDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWC7</accession>
    <name>L7JWC7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative WD40/YVTN repeat-like-containing domain, WD40 repeat-like-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1431"/>
    <dbReference type="HOGENOM" id="CLU_811793_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWC7"/>
    <dbReference type="OMA" id="FNDKPLC"/>
    <dbReference type="OrthoDB" id="2195891at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="342" mass="38592" checksum="32D0B303DBA7194F" modified="2013-03-06" version="1">MSARKIFFNDKPLCLSQVDGKRVLVSTADCKIYMVDPPYTGKKLLFEGLSPISCVEHQNGEIFFGDWNGCVYRMSIDVNERDSCTGNINTDENSMKGGINLPSDGTCPSVTTKRIKNVQNEIEKKHQESADSSSKKEIERVKNVFIKNAIIKSMKIFNGNVYVGINQKLIIMDKNLQVKTRINLNNKILCFAVINDQLYMGMSIPSILRFNNGKIEEIPTAHQSSILCISTDENGDIVTSSADKTLMVNNRVVYTGAEWIRVCLCLYFTDGNAVKKRTGKDSSTLFVHEGYVVGLQQNEEWLFSIGLDRCLTAFRKDGKMKMDVLGDWDEEEEIKRLNDEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWE8</accession>
    <name>L7JWE8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1411"/>
    <dbReference type="HOGENOM" id="CLU_2777702_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWE8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="69" mass="7755" checksum="DBCDB74B65F65474" modified="2013-03-06" version="1">MGEEAIVEKENGGVIYEDYVVNGEGVEEENNAHESDNEEENGNENSNVEENDNYNNNVLDENQNSHVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWH3</accession>
    <name>L7JWH3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993919">
        <property type="protein sequence ID" value="ELQ75823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1216"/>
    <dbReference type="HOGENOM" id="CLU_978480_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWH3"/>
    <dbReference type="OrthoDB" id="10499263at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="285" mass="31155" checksum="C47EC61D9D61B066" modified="2013-03-06" version="1" fragment="single">VRYATVPASSYPPCSGQQLPGSYQNTCVDQNGTVRYSPATIASYPPCHPGQQSVQQAPQPQQQPQPQQTVRQVQPAQQVCIDSTGTLKNTTEPLSLSNTYPPCSPTQQNAYPSCDSLQQRINELCKPSANTDMAGNTRNLQCVDSTGSVQQIVIEQATQCVPQNTTPSYPVCPGNVTLHLPSSTESFGPEWTTCTQPTDNVVYVYQPVNTEVEVFDPQNFQSRSAKNVSSSNQVVFNDPQFCTQYCQNRQLSPVFAEINQNGGPNVYNVNPGVCTSERKEDCCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWL9</accession>
    <name>L7JWL9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal trans-2-enoyl-CoA reductase</fullName>
            <ecNumber evidence="13">1.3.1.38</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">THOM_1224</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2E)-decenoyl-CoA + NADPH + H(+) = decanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44960"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:44961"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2E)-dodecenoyl-CoA + NADPH + H(+) = dodecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:44965"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2E)-hexenoyl-CoA + NADPH + H(+) = hexanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44956"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:44957"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-octenoyl-CoA + NADPH + H(+) = octanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:44953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2E)-tetradecenoyl-CoA + NADPH + H(+) = tetradecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33764"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PEX5, probably required to target it into peroxisomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.38" evidence="13"/>
    <dbReference type="EMBL" id="JH993920">
        <property type="protein sequence ID" value="ELQ75819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWL9"/>
    <dbReference type="STRING" id="72359.L7JWL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1224"/>
    <dbReference type="HOGENOM" id="CLU_1807581_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWL9"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019166">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033306">
        <property type="term" value="P:phytol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052388">
        <property type="entry name" value="Peroxisomal_t2-enoyl-CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317:SF7">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ELQ75819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="15933" checksum="6CF246AC79ED6D2C" modified="2013-03-06" version="1">MSYNFLNKVVVVTGGLSGIGLSTTIKLLRQGAKVVVGDLAHEQEIDFVVSKINESAPDSNVHHNLRFLRTNIHSWQDNVNLVDFALDEYKGIDYVVANAAMIRRNGEGASDEPTLDEFNEVVNVNLGGTFAFNKLCINYWKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWV7</accession>
    <name>L7JWV7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="2">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2"/>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWV7"/>
    <dbReference type="STRING" id="72359.L7JWV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1246"/>
    <dbReference type="HOGENOM" id="CLU_1820510_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWV7"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="16517" checksum="AD18150C4E6EA131" modified="2013-03-06" version="1" fragment="single">VIISFLEKYFSEPASDIKSYNSLELAKPPKFSIGINNSRLRNLLQALHERWNMLYKETIPNANDCMSTLIELPHPFIVPGGRFRELYYWDTWFVLEGLIASGLKEASVNMLKNFIYLIDQYGFIPNGTRKYYLNRSQPPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWW3</accession>
    <name>L7JWW3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1251"/>
    <dbReference type="HOGENOM" id="CLU_111262_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWW3"/>
    <dbReference type="OMA" id="VCCRFDL"/>
    <dbReference type="OrthoDB" id="10376393at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="173" mass="20155" checksum="5C76D9D9989F998F" modified="2013-03-06" version="1">MSGVIDYFYYDYILYHNIKRFINGEKPKFDIVQLLASDLKGIEEQLTLKLKLNKIISILQTNECKNMMVCCRFDLISKLGRCILIQCANEELQNVLLQTYLVIGKNKNAFASDKVYNMHVRSFKNKIRRIHKGIAKKSGDKSGSKVLFRVGSEQFNILFTALMVKEFKKFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWY4</accession>
    <name>L7JWY4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="JH993890">
        <property type="protein sequence ID" value="ELQ75988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWY4"/>
    <dbReference type="FunCoup" id="L7JWY4">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1040"/>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_1"/>
    <dbReference type="InParanoid" id="L7JWY4"/>
    <dbReference type="OMA" id="FEETLYC"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="225"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="327"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="398"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="7">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="474" mass="54894" checksum="43EC12000B350999" modified="2013-03-06" version="1">MIDIKLLRDEKTRREVYESEKNRFKDPEEVMKAYELDQLKIKMMYEKEKIAKEMNRACDEMKKMMKEGDDGNVEGKGGCNGDECADEEDRNARIEVEKIKNMSITEKDDEQNTGGKKKGNCGVALREKIAGLKARRAELEIKVKQTDEELKRVLKNIGNVLHKDVFVSKDEEHNPVITRYESGVKRNGKMAYYDVMERLGCVDMKRGSKVCGHRGYFLFEELALLENALVRYAIDFARTKGYTLVQTPVLMNRDVMAKTAQLSEFDEQLYAADEQYLIATSEQPLTALYMNERILPEQLPKKFCGQSLCFRREAGAAGKDNKGIFRVHQFEKIEQFVICAPEKSEEMHKAMLAVSEQFYQSLRLDYRVVSIVSGEMNDSACLKYDLEAYFPHSKRYRELVSCSNCTDYQARDLEVRYGITKENDRKVYCHMLNGTLCAVQRTLCCLVENYQEEEGVRVPDVLVKYYGDEMIRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWY8</accession>
    <name>L7JWY8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993900">
        <property type="protein sequence ID" value="ELQ75944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1094"/>
    <dbReference type="HOGENOM" id="CLU_004199_2_0_1"/>
    <dbReference type="InParanoid" id="L7JWY8"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1471" mass="170963" checksum="755DD64D3B6D1598" modified="2013-03-06" version="1">MLSPSAQLTIIYIILFKNETRNSADNDYIITKDLKSVYLSSILDESLSNDKAEMNGFSITDYDIINDELDILHSKEMEEICIQPGPREQNQSASSVADKSMNYNPQYKLIKVPCTKALLNRVITLSDDLEELPSDTDITEILQYPILYSSNNILLYKFVQRYLKNFDFSEKSNFNLPAMYNKIESCTAYGFIDEKGNTAVTTSGGMKFFVAVHNKDIVGGKIMPSINYFACDVQYIRDNMSVMREKIFCGQNRGILSTIDIDFRTHICELLLEESKDIRSEALVTQKNVCIPSLLPDNFFEKIVVQKVVIWLCNAEIELNEFYLPVEEIVLHCHDSTIRITGDVPDNLTELYAQESFIGDRMTLHSKFKTLVLKDIKIESEAEVVINQECSVIELMNVFGGRIRVPFWEKHKEKFTMKSSCEFILWKNNDEFIEHLYISNMELHKNWDINENIKELELCNIISPRNAIIVINEDCKSLSLTKCKCRFSFLRIKLINKLRLQSRMTVERFVLNEEKKPSSYKPAEYHYHSNEEEAYGSIKEIHIKNTEPRGNDSIKIPNGCNKVALLNWLGTVDLENLGFGKLIIGMEKCTFNYEYKDAERLYFLSIEGGRIDWNSFRSNKRYNLHLNKVITSENSILNIGNNCITFTATNCQGHIKVPEILESECKSIRLDGENNFFYLKKLQNQKYFLEMSKIPVEDKLVFNDEIDTCVLIGIKVKENAEMRFKPDIVKFATYNSRISVNKAVVEDNNGPIKSRASDTGFVGSDNEILHVHKLYIEKNQSCKNVKILNLEMQKKLQDSESHINLKLENIYITNYSGKIFSQIFGPLTACLNFKNDGAFGFLKNHFVDEYIMQLQNCEIENGMTIRYDIKHLVLQKVTATHGIDGSQNDNTKWMDTFKIQGLRSLVLSDMKGFDYKRFTGLNYLQLENMTIEQNISFDEPIRILKLKNVTADNITVTINSSIEELHIQNCSGLFEIDQLFSILRKKENEKWIIQYKNQSDDKGMYLYLEGIKFNHNFNVPQSVKTLHLKNITMLDNLVLRIDQNCENIDIEEFLGIIETPEAKLFKNATFHSKLPIFIENTRNCSDNVETTWYFENDKEIIRLPNYLRTINLMNIEQGKSLELIIGEQCKELSLISCSCDFDLSEITHLRKLTFYPTPYSDINIELSHTIHVDELDIAYNGTGKYFRWFLVKCSSVKRLTIHAWNTDCQEFEIEKIKDIGMYGCTDIEKGRIENAYNKLVPHCDQDGEYSKQELLNTIMNILIKPIFYCRMRNTLESISLFEFRLDTANAKRLKNSFPLTNISIDYRMLDAVLLSNLPNNLRKLEIASDVGILTDRMKNRAIYKYEIKTLLSEQKEIEELTISLHFFREWKNLSFLPPNLKHLQITCFVFYAYNISAVDKKLNVKKLTIHRYRSMSQVIEQNEIMLKIYLLKIYDFLSQFIEIENLDELVVENTEGVIIKHTPSKYRERIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX00</accession>
    <name>L7JX00_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX00"/>
    <dbReference type="FunCoup" id="L7JX00">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1001"/>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="InParanoid" id="L7JX00"/>
    <dbReference type="OMA" id="AESHCGQ"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="4"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="331" mass="37628" checksum="DECD2D7CFFD64067" modified="2013-03-06" version="1">MEDSKKIIDFVNKNRNDRGYEYHSCTYLHLSMHYWVTTIFNILGYTDEAVAIETIEFLKSCKNSDGGYGSTKGYPSTVFNTMLACQVATMLNYDFYDEETVDYVLSCCNNGVFYAEKWCGDFIEEDNRFVCAALISLVLLDVNRRKNMGELDSSTDLTTKFIISDDFFSLLLKKGFEKEKTIRYLLKCYNMDGGFGCIPGAESHCGQIYACLVSLKLLNALHRIDKTRMTFFLINRQEPSGGLNGRPYKKEDVCYSFWTLCSLDILNGVKYIDSNKLREYIEKCQSADGGYADRPGNVSDCFHTMYALLGLCLLDNNCGCKDVFHLGISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX11</accession>
    <name>L7JX11_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative WD40/YVTN repeat-like-containing domain, WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1073"/>
    <dbReference type="HOGENOM" id="CLU_774305_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX11"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="358" mass="39236" checksum="3F2A1A96F74C3FCE" modified="2013-03-06" version="1">MLISPYQHSSSQPFTLFTHTTTTLFTSSSSSLHAHTQSPHILTKFSSPITAMHANRLGVAADHTGTIKLFTDTHILKQFTYHRARVNAVRLIEGRCVLSCSDDGTVVWNELESVRVLTGHNDYVRAVCLDECAVVSGALDGCILVHDLRESAPVARYAMDAPVLHLESSDGVVYVSTPTGITRFSVAQRAALRSTVNYGVNDLRVCNGLVYACAARALTVYDRNLEEVFFCRFKDESAGLACVNGEVLVGLKSGTVLGLRTQSVNEDFDENQSFNEMVYDAMISRSAQARTYDKTEGDNDGEINGEVDNDEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX26</accession>
    <name>L7JX26_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1779"/>
    <dbReference type="HOGENOM" id="CLU_703156_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX26"/>
    <dbReference type="OMA" id="RYNNIEM"/>
    <dbReference type="OrthoDB" id="2190774at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="393" mass="46920" checksum="10EAA0ECE23CFB33" modified="2013-03-06" version="1" fragment="single">VMDKYVVEHCIGISPPFLERSCTKLNKNTVKHNYIGDRVCSFVYLIELVPLNADIETFENLYIRGYQENMHKRYNNIEMHLKMDGRKISNFKETRIVTFNCYDTTVLYILSQYKEIIRLFYCSFSGCHTTRKGKLLLYEIRLFDKHSFFKIMNEPVYSVEIKVINVKTKNKTNNLHYNWNSLKEQNDSEMCHIELLGERYVLDQNMCIFCFKNFSSFNSLNDHVNTMHVYYKSSIKREVDQNILVIKRVDLLYKVKETFAFRNKRKAERSDVPKGSFVSMLYRNAEFDIRNDYNAGEFRYFSAKRIGEIIDTNERKLRLMKMWNDFIIYKKSVGVLPRKYDLVKEFTVILNDTKDILEILILFYQKSILTKNEVLKMINELSLIVREESFTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX78</accession>
    <name>L7JX78_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear exosomal RNA helicase MTR4, DEAD-box superfamily</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JX78">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1733"/>
    <dbReference type="HOGENOM" id="CLU_002902_0_2_1"/>
    <dbReference type="InParanoid" id="L7JX78"/>
    <dbReference type="OMA" id="LNMPAKC"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="90"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="498"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="806"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="824"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1066"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1080"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1102"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1114"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1567" mass="176502" checksum="20F9E24D9182163D" modified="2013-03-06" version="1" fragment="single">VQNFLSHPQMNKNSKFDFTSAFKDTTTLQVPQKKVSTHKKTRSVDKLCRDNTLHEAIVPEDAPYTRIDLAQPIDTHIFSYDLDLFQRISCIALERDENVLVCAHTASGKTAIAEYAIHLALKRKQRVVYTSPIKALSNQKYRELKLKFDDVGLITGDSTLNPKASVLVMTTEILRNMLYRSNELVGEIKFVIFDEIHYMTDRERGVVWEECIILSRFNCVFLSATLPNANEFAEWVVNVQGRVCHIVSNDRRVVPLIHYVFPVGGKGLFKIKGSGEGMGGEDDVTRGDEMKGGEGIGGEVRDLKTRGGDTRGEARGGEMKSFTTRGEVRDLKTRGHDTRGDDTRGEVKNLKTKNPKKYGKEKGIKKYNGKNENNDKHGKMSSRTRKEDKTDRKNSKKGKNENSTCSSDDRLAGGDDKRSKSGKTRDDPSGSKRTFNRGRGRKEDGRKKRTNERSTKKVAKATQRALKAYSPTSTVDFNVEMFNEAIQNIRKSRVDYADIRAIIGLLTERGLLPVIVFSFRRKECENFATCLEEDYNTAEEKERITLIFNRALETLRAEDRTLSPIQSMLPLLVRGIGIHHSGLLPVLKEIIEILFSLNLVKVLFATETFSIGLNMPAKCVLFTTLFKFDGEKMRTITSGEYIQMSGRAGRRGIDKEGICISILTEAINIESAVALFNGRSNPLRSAFHLTYNMILNLLKIEGLDPVYVLERSFFHYQKIKGVERLRDTVNYFYGLIGKVESVDVGGNEDYKGVVYKEGVVNKDVEGKGKNEGMEGVINKGVVYKEGVINNERVINNEEVVYNEGMVNNDERVINNDNNDDNDNNNDNNNDHSLNTVNVNTTINPNNNVQAGDFEFLNDALSHRKLEDIGNLSELLVKGRLIDVILNVNGFPIYLQNCIISSAGALNQRNKKTDSNVNLEVVVLLYNRINKMKRKCIKLHEVRAIYDARVKISNKRLGRKYAVLYGTPVDGHYCTICEGEVGVACLEERCFFDVLERFMSGANIGGFDRRMVGREEEVPVGLSSALTVECRRDGVLSGDMSGYVDVCGGSAEDEEDERIGEGRIGEEEKDVDEKDEEDERIGEGRIGEEDGRDVDGKIGEDERIGEDEKDEEDERNEKGSNKEEKNHLEIINERMNDKEISRVNVQETDRSNSTEDTSSAAEHTSPSSAGTALQGTASPVLKRKILKYLNNVYNAKNGDLFLASRIDHIDQCTKMIQVLRRLDYYDNNSITVKGRVACELNTEELVLTELIFNGHFLKLSVVEVVSVLSCLVFTEREDAEVSEQSLRNYKLIEEVVHNVVKVMNQVGLNVQVEDFAYSNELMDVVRMWAAGASFESVTARTQVFEGSIVRCLKRLDEMLRQLSCAARAIGNLEMERVFGEGISKIKRDIVFCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQRLYDAKALQCFTSYVNDRNIRIALIYFYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXB5</accession>
    <name>L7JXB5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXB5"/>
    <dbReference type="FunCoup" id="L7JXB5">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1338"/>
    <dbReference type="HOGENOM" id="CLU_072378_1_1_1"/>
    <dbReference type="InParanoid" id="L7JXB5"/>
    <dbReference type="OMA" id="KEFMNIT"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="138" mass="15810" checksum="6986A00F017C5F81" modified="2013-03-06" version="1">MLIDSEVDDHVLNQYKQKRLSELKKALPVPSITSRQSLLNAITTQRCIIHFHNPEFARCRIMDERLAEAADIVSDIKFYRAEAQLFEDVCEYLKINVLPFLGFFRDGKCVDGIVGFEGLSGDDFKTSELVKIIKRSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXH9</accession>
    <name>L7JXH9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1274"/>
    <dbReference type="HOGENOM" id="CLU_1778765_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXH9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="17383" checksum="498017D21FB1ABA9" modified="2013-03-06" version="1">MLLSFLSLIPLRQRSTCSPSCLTLHQKYSDRDLLTIPTMFHNSFKYGRFSLQPKQEQKIRMTPMTRYNDLPDKENYDPLAECYSPHAKKTGSIRRAILKDITDKYRKRVVEEKEPVDEPKKWSEEIEELFGRWKDSPVKKKSMREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXI1</accession>
    <name>L7JXI1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXI1"/>
    <dbReference type="FunCoup" id="L7JXI1">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1028"/>
    <dbReference type="HOGENOM" id="CLU_028556_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXI1"/>
    <dbReference type="OMA" id="ENTICAC"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ssl1-like" evidence="1">
        <location>
            <begin position="50"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="334" mass="38608" checksum="0E2FE821D4F9464B" modified="2013-03-06" version="1">MSVPFSWEKQYKRTWENLNEDEEKNTSLEKKLHHTYAPYKKGIIRHFHIIIDSSASIELNDFLPSFRYHVTTKLNHFIKKFYDENPISVLSLLIYRNNKCESYIVLDRLSETEGFFGVAGTGEFSLINSLNVSLEFLNRDDYIKEILVITGSLYTIDIEELRSFKDIKIHFIAFRAEVYFFKDVAEKTHGKYYVPVEMSDISLFLESFCMPNSINSGSAHNLLKLGFPQVLTGDLVCACCFRYSKKGYECPVCHTKVCNLPIKCPVCKTQLVTSNILAQSLYYCYPLEDFEKAGGACRVCGGDGRDRCKKCGSIYCERCSYFIHNDLYFCIYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXK3</accession>
    <name>L7JXK3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1526"/>
    <dbReference type="HOGENOM" id="CLU_1887213_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXK3"/>
    <dbReference type="OMA" id="IAYESKE"/>
    <dbReference type="OrthoDB" id="10384827at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031533">
        <property type="entry name" value="DUF5093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17011">
        <property type="entry name" value="DUF5093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="135" mass="15866" checksum="1C049565E04594A4" modified="2013-03-06" version="1">MAATQVNKITLVFPFNVPGITNRVTLSTTMHTRDATLSFALPFLLAFTTKPPNNSYPYAVKVKKSNDMFVYILKFEPIDLKRFIVNCELHVVKEMADEYEEITREMDERMEEYERTEKMGKKKKIVDDDGWIRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXR2</accession>
    <name>L7JXR2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXR2"/>
    <dbReference type="STRING" id="72359.L7JXR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1213"/>
    <dbReference type="HOGENOM" id="CLU_689258_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXR2"/>
    <dbReference type="OMA" id="IVINHIT"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="400" mass="44887" checksum="917DE075C174186B" modified="2013-03-06" version="1">MRTTHSHYKETKRKVNDLWALALYVVFMAGVLTYTAFMSKTKSYLDLASHFDMKVLIFTFVCGFLSFGVHLAALLYFPGPAMHLSCIVIPILSIILAVLSGNIIGIVVSVIFSALMLVTYLFYLRKHIKYAAQIAKSAAQLVCTSIFSTLCVLILFLAGWSGMIYFFVTVSTGLSKQDRIIGLAIEALAFVWTLFVLCYSLRVFIASIFVVHYLMRSISPTQRAVEAFKNWLYALGSICFGALIIALITVLRMLVDRERDRSGSVGSFFYSILLVLLDILQDLVNFSNEWAYCYVALTEKATWNRLRNRGASSAGQGTTRSPTVCRYECCSHFFPSCFFWCTRLDCPSYLTRRIHRSGISHSPRTSSSCSRISSSDTVYTPCLILVLSRSSLPTRCSPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXR8</accession>
    <name>L7JXR8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1485"/>
    <dbReference type="HOGENOM" id="CLU_1349740_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXR8"/>
    <dbReference type="OrthoDB" id="2196372at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="203" mass="23842" checksum="D779668EBF30B6ED" modified="2013-03-06" version="1">MLKKKMLKDQNFLDREEAEKKEMELKKLKREYEHMKGSLNQKEDIIQLQNKVIKQLENNNQKMKMVYGDEQYDNDLESSLVLLDRKINDNKKKLPETKDKTPMYVDVGDVLQRNNDKNVQQSIKNPKTGGTNEKSTKKRKTNVKSIKNMVKDKKVPFSPPKVKAQIKQETPKQPPEDRNVSFFQNLTFSDSSPVIKKPFFKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXS7</accession>
    <name>L7JXS7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0916"/>
    <dbReference type="HOGENOM" id="CLU_580306_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXS7"/>
    <dbReference type="OMA" id="NNINYIM"/>
    <dbReference type="OrthoDB" id="2191110at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="471" mass="55261" checksum="C2015D697EA80E93" modified="2013-03-06" version="1">MKYDDYEKLVNTLAKTDKISQNLNQIYKKMENNAQNTPTTVLQTFERYSTPKKNLDYAIKFHNDYIKYCESVDESVVVVVDYKKTKETNIAKDLEAIKAYETIKKCNNNVKIYRNIGIVKAKIETSENALTGIYSCVKKRFFSLVKENLFIEVDGLNKISTFLTVYGEKSEIAEKYMQIYIKEFNFRDALENIDTFVKRVTESNKLFSDIRQMNVFLFDTATYEFLNKAMIDYFREDMKTNIMRLMDLIERRRNLHDIFVVIALYDVAKANDIDLLGCMDSLIHHIISYIGDINQIDKKYEVENFVVFTTKVVQSFNPQVMQDYIEKYGANLKVKEQNELVDKLLLTLYMKIKHLSVNESALNRNVYLLNNINYIMKTKNSIGDKMLFDDVQTFKKNIINDLKSESARYNDNCTLFINNTIGFFSRTKVPSETRNYILENVKKIVKDLTKRTTYDGDVEEVVRKLDELELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXU6</accession>
    <name>L7JXU6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993909">
        <property type="protein sequence ID" value="ELQ75876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1161"/>
    <dbReference type="HOGENOM" id="CLU_1074371_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXU6"/>
    <dbReference type="OrthoDB" id="10433702at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="259" mass="29342" checksum="6C2F62E4B2A87AD7" modified="2013-03-06" version="1">MNVLHASLPGHRHPPAKHENASLTSNPNETLSIDKHSSLTKHVPILCAVLHSILIHAYIPTDTTITLTTSANLHVYNDPTNFTKCPYMLSPTPSLAILKKYGTEYAIILNNAYLCSLDRKVFENRTKCLWEIQQNAYGYFLRRDGLCYRGGCTMVECNNNDEDQNYLLIEKELCVASDNSTLAGRIRNRMMGSKVESEDGDDDKSGVIKKMEEKYGRIGKKMKALINALHKDKKKKKRKSRKGLSWKRPSWKGVKLSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY04</accession>
    <name>L7JY04_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1108"/>
    <dbReference type="HOGENOM" id="CLU_1195649_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY04"/>
    <dbReference type="OMA" id="TRKWFIF"/>
    <dbReference type="OrthoDB" id="10307184at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="233" mass="27633" checksum="FCC0B71E799539BE" modified="2013-03-06" version="1">MEILIIYIYNFLTTRKWFIFVFFCLTNTLMFKKYTNEELTEDPFKIIELGASKTTFYKVPNEKVKTNYMQLHVPFIIDKLFHLQNDIEYMSGSIKFVIRPFKDVFMVKEGKKTFIGRFVRSFIDNESYWQVFEKGDKCGFNKNVRWSARVQFTGSIDNLRVVRLIEGNLCNYEIKVVGDILTRKITNKDTIIYKGDKKDEEDESTEEEEDENDDMMQSFKTFKMKLLGGASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY29</accession>
    <name>L7JY29_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3'-5' exonuclease</fullName>
            <ecNumber evidence="7">3.1.13.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="7"/>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY29"/>
    <dbReference type="STRING" id="72359.L7JY29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0651"/>
    <dbReference type="HOGENOM" id="CLU_054620_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY29"/>
    <dbReference type="OMA" id="THCSYED"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="75"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="300" mass="34852" checksum="AF78775CD2679501" modified="2013-03-06" version="1">MCEIESIILKDIGDDVRPDIKVLLHVEYLQHFVVKQPFSIYLEDDRFVNSDVSVREMNKIDLGVYKSAYRHTVHKLIAIDCEMLLTNAGVELGRVTLLDIHGNTLLDAYVRTDNTVIDYRTEYSGLSEQSFVNSVRFDEAQSMVLEQVGVDTIVLGHSLYNDLKILQIKHDKLIDTSRLFRTHGNYKISLKSLADKYGCISIQNNTHCSYEDAYACLQLLSVKVRVLYELFHSERYFGFVKTDRKVCLDKLKVSERCVRTAFVSLRELESLNVFDRVNNYYMVIYTWMNKMYAGVYDSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY50</accession>
    <name>L7JY50_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Zinc finger, AN1-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY50"/>
    <dbReference type="STRING" id="72359.L7JY50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0628"/>
    <dbReference type="HOGENOM" id="CLU_1918540_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY50"/>
    <dbReference type="OMA" id="CKEIKRC"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="132" mass="15073" checksum="77025C901A3BA414" modified="2013-03-06" version="1">MSVLVEHGIETISTKNSGAKDVSELKKKLSEKVKDSDFWIEANGTVLADDALLSELKGTVTVCYRKKYCDFVDCKLKRSKVCSDCRFCKYLFCGKHKMPEEHMCKEIKRCKEEANLKNANKLEEGRISKNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY58</accession>
    <name>L7JY58_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Histone deacetylase</fullName>
            <ecNumber evidence="1 4">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="1 4"/>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY58"/>
    <dbReference type="STRING" id="72359.L7JY58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0595"/>
    <dbReference type="HOGENOM" id="CLU_007727_7_6_1"/>
    <dbReference type="InParanoid" id="L7JY58"/>
    <dbReference type="OMA" id="ITDFYYL"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="400" mass="44447" checksum="DA7C89665B53158B" modified="2013-03-06" version="1">MRVAYTFNKDVGNYHYGKHHPMKPYRSAIVNNLVHLYKLTNHMDVLAPTKHEASGYHPDGYPFDDMKTTDDCPLFYGRKAFCAEYTSSSICAANALLTYDVAINWAGGMHHARKNSPSGFCYMNDIVMAIQRLLSSFERVMYIDIDIHHGDGVEEAFGLNERVLTCSFHKYGDGYFPGTGNLLSNHFSCNKAGTQQMPCGADDGVQKDVQAGGVSDECTGGSAVHSECSGADPLAMHRPFQKDKKIKNVINVPLRTGIDDWSYKYVFEPVTSSIIRKFDPDVIVVQCGADSLGEDRLGCFNLSVQGHGACVEYLKSFNKKMLVVGGGGYTLKNVVRAWTYETSVLVGVEIPGDIPQGTYTEYFQPSNSLFPDFKRKYENENTKSYLDSVTGYIHNVVDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY63</accession>
    <name>L7JY63_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0600"/>
    <dbReference type="HOGENOM" id="CLU_1896187_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY63"/>
    <dbReference type="OMA" id="NIYYEPY"/>
    <dbReference type="OrthoDB" id="2189046at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031504">
        <property type="entry name" value="DMAP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17024">
        <property type="entry name" value="DMAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="134" mass="15918" checksum="58DF7CE267A25FFA" modified="2013-03-06" version="1">MPQLSLKKKHKLLSTYRDFLGSLPSTLDRRRKILQTHFGEILVAIPTEEDFESKINNIIGKLHPHPYIYLASTIGFSKMTWNRSVEKILDQFGLKMKLKYPTLKNYLRYEKLKYLLIRYFDKRKELGLQNDSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY66</accession>
    <name>L7JY66_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1334"/>
    <dbReference type="HOGENOM" id="CLU_146217_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY66"/>
    <dbReference type="OMA" id="MTTINIY"/>
    <dbReference type="OrthoDB" id="10355933at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="14165" checksum="D48EDA8BE8AB395E" modified="2013-03-06" version="1">MNLHDDIKDQDIAIKSSFIMTTINIYGMCFVVHALLRKNVFQVQLFNYILGIESLLPLCNTVLFLVNRNVRESIFSFTMVLCNLSEMLYTIRVTKAAEYEFFWYYSKQTGMNMSMKGKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYB1</accession>
    <name>L7JYB1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1384"/>
    <dbReference type="HOGENOM" id="CLU_2962541_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYB1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6818" checksum="0CCC22F12B0B1C1F" modified="2013-03-06" version="1">MKIQYEEDSSTTIEINNPMNYELELGIALSESLHRNAILAPEVVQVKVAERLEKFLREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYK9</accession>
    <name>L7JYK9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="JH993919">
        <property type="protein sequence ID" value="ELQ75827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1220"/>
    <dbReference type="HOGENOM" id="CLU_326830_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYK9"/>
    <dbReference type="OMA" id="EDECVRI"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="316"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="881" mass="99373" checksum="49AAB6018612D092" modified="2013-03-06" version="1">MRNGNKPRRNKTKECKDKNAPVNTITAGVTNLTLNDGNNSKDSKGKDSNNDTTTTDTNTTTDTTTNPTTTNPTITTTTPNNYINIATYLKNRLPSLKASLPHLKSSSTTAHPLSQSPLKLLLKSNHYNRSDRIRITGNHSNVLKIVKVKGNVIECDGDCVVEGVVRVDDERYRMRRRVVGEIEWVVGKGLMGCVDVCGDGVDVYGDEWINCEDEGNVVDRSGEVRKDDEGNVVGRSGDEGEEENMDGYNNNDNNSSNNGINNSINNSINNGINNSININNNINKNKNKTHEKEINDASQHNIPKLNASQNKALSMCTSSLKILGPPGTGKTYTLIHIIKKLLNDGKRVLVCAPSNLALDNLRRWFSEDECVRIGGKSKFRNYEDIARKEKGRYSKDGDRSSRGSDRGSRGSDRGSRSGDRGRYSKDGDRGSKGSDKGSRYSNKDKDKNKYKDSNKDKNKNRNKHTFHKTTKKGIANKTSINNNKGNIQRTDYALLRNYDLVFSTLYSLYKIRDVYDMVIVDECCQADEDELVMVFFKGRNVILAGDPYQLGPVDEGHNGKNGCDERSGDESGEGSGDERSDESGDEKDSSFDEERVNEGNGDEERVNEGSDNNSNKGNNNKDNKGKTTTTNGKTTITASSDKNKQKKKKHKEERKTRNRRYKTMAQVRKEINNCMFNRIRLPTVLLNVQYRMPANLIAFSNRFFYRNMLRSVQPLSLQFFDHSNLMLINTAHRNFLEHKDVSIINVEEGKLVIAILSFIDRTYNVRSIGVITPYAAQAQHIMRSIDMSTFRAHVQISTVDSFQGQERDVVVISMVRSNWEKEIGFMDDVRRMNVAMTRCRMGMVMVGDKRCFEWVFYRRVFEFFEGGVVLGPEQFYSLVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYM6</accession>
    <name>L7JYM6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993842">
        <property type="protein sequence ID" value="ELQ76534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0481"/>
    <dbReference type="HOGENOM" id="CLU_1225520_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYM6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="226" mass="25871" checksum="606AB00367D91559" modified="2013-03-06" version="1">MFKFFTPNANETTPIKGSPDNLLILNIQNMEITNNMELSNYFEDVKLENITMKNNTKLVLNGRCKKLTIKNFNGIIGVGNVARFEMIEIHFPIDEQVNISFYGPVCTTKLYLYNVCKDVSNVKSALSNFRDVKNLKFENKSSNCFNIDEPVHVSTLKSIPLCQNAANKYVNTWSKYFTSKANSKENLFHAVSNVVINFIIEFLLNELKLELIENIELMSLTFAENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYR3</accession>
    <name>L7JYR3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RRM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1137"/>
    <dbReference type="HOGENOM" id="CLU_3108107_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYR3"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="51" mass="5927" checksum="BA4DACDFD1877F3C" modified="2013-03-06" version="1">MQRKGRSRCYGFIELVSGDEFVEIIEKFNGKRVNGKPLRIRKGRNSPMKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYS4</accession>
    <name>L7JYS4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0299"/>
    <dbReference type="HOGENOM" id="CLU_2504102_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYS4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="86" mass="10136" checksum="030F4AC2A08D8A22" modified="2013-03-06" version="1" fragment="single">VFHSKMTCDDSRNIWCSFYTKLGHAPYFRNCTAGLIMIYQRLILPRVNVRIYRLKAVAMAGHSRIKGRVANNWTMSMMVIIKERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYT9</accession>
    <name>L7JYT9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0344"/>
    <dbReference type="HOGENOM" id="CLU_3175705_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYT9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="47" mass="5228" checksum="58F085B55B7E950E" modified="2013-03-06" version="1">MNQRPMAMVSPSEPEECVRLSEVCGGNKYTSEKNMLIATYTIVNACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYU6</accession>
    <name>L7JYU6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993902">
        <property type="protein sequence ID" value="ELQ75927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1114"/>
    <dbReference type="HOGENOM" id="CLU_622851_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYU6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="440" mass="50352" checksum="92897E1821F7F30A" modified="2013-03-06" version="1">MKYDMQIIGILVLTIVVIRCELRNLLLDSLQSDVVSNFNIMSKCESMDLKNFSGIMNMQPVLRFGMALLNHATLKYSVNTRTLVLDGGLHLNTFFLPHWVEHLKLNGLTMNNSEVFHLHRNLKNIEICNCLGTLHFADMFNIGELYVEHKSAIDMKDLGGSHTSMHFKNLSLNRSLNIPVGVVSIMLWNVTMSDKTVIRISSECESMIVGLSQCVINWQNTTGMDILECAVKELYKFVRCDGSDFFMLDLGDSYLTKRFTIPDNAAVICLTHVNGSKEFPVLVNESCKTLIIDNCTGVVVCHSLKSLELLSMLRFGLNNLEVQFNRRSNATLEICYQFTHNRSLQLAICTKNLRAIVFKCESLNITMAEMMNNDKCHFYILIPTTSHHLARNIESIYSVNITKIDPITILKEHLRMNKTHRREFRMQRIVKIDFKNITLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYV3</accession>
    <name>L7JYV3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0330"/>
    <dbReference type="HOGENOM" id="CLU_877686_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYV3"/>
    <dbReference type="OMA" id="NCGERIK"/>
    <dbReference type="OrthoDB" id="10565340at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="317" mass="36669" checksum="F097C95D9A01D1A5" modified="2013-03-06" version="1">MNVRDLIRFYEDKIMIVKDVACVQNRIVEKIPTKMEDTHLHQWPKIVYELGDQVRTKAHCDIDDKKHGDLVKKMKRLCKGQNIGEETKASAVLIENECAMNEYRMCELRHVVNHDNWYVKPSTVAAREREKHYIRQSFHGKKNSAIAEKPSIGQDQTNNLVELANEEVYKAVEKNNSIDKSYGKIMPGNRSNVIVENYLKINIVKNLNEKEHHETAHYCTKNNSSCNNNATNSQSIGKYEKSTTTFLENTEHETSGDIILIHKELSDHPEQTNRVSKDHDLYKNHLYTGDMDVDKVKLILNCGERIKTSYLLDGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ09</accession>
    <name>L7JZ09_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Brix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ09"/>
    <dbReference type="STRING" id="72359.L7JZ09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0392"/>
    <dbReference type="HOGENOM" id="CLU_109938_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ09"/>
    <dbReference type="OMA" id="RMFEPNT"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="190" mass="22205" checksum="4DDD287000A8B809" modified="2013-03-06" version="1">MVENEEHEIKFVVRYGKVSKKTKVLLTSIKRMFEPNTNTKFNETNKFDLKLYKKLAEMYPIDIFIVLKESKSGVHIKICKANEQTSVYLQVIAFDAYSVNGNYKSDALLTFNGFDEDDAFRKLFGKQHFKNVDSVERVINFTKNNELIYVRHYKIIKTEGRCVKIGLKEVGPKIQMKYVKTDESSLGEHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ29</accession>
    <name>L7JZ29_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation elongation factor EF-1 alpha/Tu</fullName>
            <ecNumber evidence="6">3.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="6"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ29"/>
    <dbReference type="FunCoup" id="L7JZ29">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0419"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="InParanoid" id="L7JZ29"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01513">
        <property type="entry name" value="Translation_factor_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="473" mass="51439" checksum="A39C4B54CFFC9A63" modified="2013-03-06" version="1">MATLEKPILNVCFIGHVDSGKSTTVGNLAFQLGAIDPRKMEKLKKEAEERGRGTFSFAYVMDMSAAERDRGITITTSLMKLETPKHMLNVIDCPGHKDFIKNMVTGAAQADVGVVLVPCATNEFESCISGGTLKDHIMISGVLGCRKLIVCVNKCDTVEASKMKSRFDEVRKEMLNIIAKCHPDKDPIIIPISGYNGINIVENGEKYSWFEGWRPKNDPNATPIFTLEGALNSQIPPPRPVDKPLRMPIDSVHKIPGIGMVYTGRVSTGVIRPGMVISVQPTGVVAEVKTLEIHKTPRSEVISGENCGVALKAATKGNPALIKPGHVVSDVKNSPVTVYEAARAKVVVVEHPKGIKPGYCPVMDLGTHHVPCQISKFFSKKMQGVADEIIGPDVVSKGENVTCIIHPQKPVVMETIKEVPSLARFALRDGGRIVGIGAIDLRYTKEEYESEVSSEKSKESKEEAPARRRARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ70</accession>
    <name>L7JZ70_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0425"/>
    <dbReference type="HOGENOM" id="CLU_004199_2_0_1"/>
    <dbReference type="InParanoid" id="L7JZ70"/>
    <dbReference type="OMA" id="NNPMKRQ"/>
    <dbReference type="OrthoDB" id="10474014at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1542" mass="176707" checksum="FC03579B191193CC" modified="2013-03-06" version="1">MNCSSSRVTATLIKWILCFMGEKENVIGDISICDNLEDMNLESFFANPTVDEENLMLTELKINDYDAIEDPLKVFEPKEEQQSSVSPKIDSKDIHKFVRSANVNRYEYGDSSITENKNEFSSNRQIFARDRECKYRTIQIPVTKSLFMAVVILTVNSDVKFSNYELYIVVDRLLIFLHDKRPFLQVLAQQFLDDPKLSDKLDIIDKTSIKEEEKVGDNGEERNKSSGDISFNTKLQNAMCEVSNFIDVVTADIFGNAARVAQNNENRLVFSTDVESLFYFYKPRYLRMNGYFFINEKWFLCRMYDDVPSGFILTIDIDFTDVFDDVAKKHTSKRTRKRLITEKIDLALRFSFLRLRCLEVCIFRLKGVQIDLSFDTISNKQLHVYCKECVVSFSTHSSSNLKTLSIIDSKICCDLVLPDTLETFILEKTRIIVGYELRVTEICKHISINQNHGKIRIPYFEHTFSALLPSDGTFELLRSGDIIEKITLINVIFYDSVVTMPNNIQEIILKNIVLDGVGLWIFPEDIKKIALEKFSGHVQLDGFTQNKPLVGYFNDGTFRSYKSNESEQINELVFSRMHLTHDVYFNSNISKIVMSYVIMDLDFSFCFNEHIIEVSLYDCTCNLYLEGLPYLNQVQLENDSFGEPRRTFCFKRPDNQCIGQVSMSNLMIEETINFGPEIQDFKFNGITVSESSYVSFAENFNELELNDCKGRFKIPGIFSDDESHTIILGENVDLFKIRRTKNDSFDILIDTLSVDKLIIEMNLKTVELYDIKIVERVLITTHQCKNLIIGGFNCPLSIPNIVSLTKLELSDFDNLNISSKMFTLTKNVTAYVTPMNEDKNTGSPASDTNIYLPTIISDCCENIFISKNRIPINITGVLRNASINTSLMRLTPQSQFGIVTCPLKHLTKFELLDERICGIMIIEKDVCFLSLSRITSDEGSELWLNKGLESIRVDSSQININGSNAKNLRAITLVHSTAIIYDPSVHTSLSYLNICRMAINHSLILVPSIATFLLKHSTLISNCSVKINEEILELSISKFIGIIDMAGVAGLGKMEFDYECMLYFERSTSYNDGGLLHIEGYTFKNDITFSGDAKTIHLKHVKIVPNAKITLGHQCTSLALTSSNIDINFSRVNSLKKVTLASVSFAVLQKIFTNLSTIEVLILQDIALESSINLPNNMHTIVLREISLCAGSLLKFNAKCCKVHFYKCIGLYNFSNIERLLALSLITHFGDKLQFKVYLPSLRNLRRLDITYNLNNELFMFDLYGCINLEYLTVRSLNYSKEVTLYPPLSFSIYEVLDFSDTNTWSKYKPSKIKSRIGKFKNESVNILNLKANILISEIFTLKKRNKLKYLNLVGCSLDKENVEVLKELVNLRTLVIDSAFFESDLVKNIPRQIETLEIVDKKIFACQTLNLRRLNFKVVQELKKYENIKHLALDGSIMGYESIFDCLPINLESLKITRFSIGEVNFIEKNRTRVVIKQLILLLDDPNSHPPVLIDNNPMKRQYYKLFDYLKNFIDFNKLDDLMLEASGKFVSLDKETYRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ78</accession>
    <name>L7JZ78_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0663"/>
    <dbReference type="HOGENOM" id="CLU_1518911_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ78"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979006" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="177" mass="20536" checksum="AC76D40F515947E5" modified="2013-03-06" version="1">MIMIIWILICMTRETILSSNTRTITDDACKNANIAIQALTFSAKCLDKAIDDHEDDDDMAPLTEKQRQNVLNQIREKETNLDNLLSTMDCTPFSNIEVRTQLATILTRDIKYILKMFCRFFSNEEDNHEVECVQNNEIQKSELGKKLDDVLRKQIKDFKLSLTCIKQVFSNDEFGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZB8</accession>
    <name>L7JZB8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993816">
        <property type="protein sequence ID" value="ELQ76764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0243"/>
    <dbReference type="HOGENOM" id="CLU_2433026_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZB8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="91" mass="10608" checksum="5301606B8CB1DBC3" modified="2013-03-06" version="1" fragment="single">VTCDTFCIKFHFLTIIFTHSMLAFRLVLYTMLILCTKREKENKMGESKLKTNKESLVGDKSVDRLDTEGLLGRIRDVVKEYESFRSNVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZE6</accession>
    <name>L7JZE6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0188"/>
    <dbReference type="HOGENOM" id="CLU_2086471_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZE6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="117" mass="13643" checksum="36B6FA16FBDC5811" modified="2013-03-06" version="1">MLWLVVVSNYMWYVSTTGYKKRSCITIEEQPDSKPKLDDAMSPCSSLDSSPDYANRLHKNLGNTNSPDREQRTVDLIMQTKVTISMEIANMEDRIDNNLRKNAELIRKIYLTNIWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZG3</accession>
    <name>L7JZG3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0173"/>
    <dbReference type="HOGENOM" id="CLU_3320316_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZG3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4150" checksum="212828AC9E4635A3" modified="2013-03-06" version="1">MKVTYLENDVLILIGPVAIIDPSGPEEYVELGEVSSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZH8</accession>
    <name>L7JZH8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 protein</fullName>
            <ecNumber evidence="3">3.1.2.15</ecNumber>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.2.15" evidence="3"/>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0155"/>
    <dbReference type="HOGENOM" id="CLU_918819_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZH8"/>
    <dbReference type="OMA" id="NGMGICY"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="36"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="284" mass="33300" checksum="7E5EE870EAD9D172" modified="2013-03-06" version="1">MYPKSYIITVVILATIFIFGLSFILWYKYRHEPLLCGLKNGMGICYLNSTMQALFSSKQFNELLTKYSSSNNEMIKNLIEIRAMMRKGKTLNLLPRYKKMFDKVGDEFDFSQEGGYPLHALEYIGIHMEKTIPNDFFLAQENYEKTKKIQSDESLKQRFLRFYPLLRGNVDEMLKNGLERTIDKKSFEFPKLLIVCLWNVHSYTDTTCDKIVCNPEVTIFGKKYRLVALVISVKGKRFGKKHAFAIGLRGNNWYVFNDEYIELIKNKKLVFNNKFCSIAFYDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZI2</accession>
    <name>L7JZI2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZI2"/>
    <dbReference type="STRING" id="72359.L7JZI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0570"/>
    <dbReference type="HOGENOM" id="CLU_087330_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZI2"/>
    <dbReference type="OMA" id="ILCQHEK"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="293" mass="33386" checksum="46C000219FD04262" modified="2013-03-06" version="1">MKITERGSAQFDEKLLSLAVTKDSVLTGGTKKILHKLSTDLHTQKILCQHEKSIRCIAAKDGVIVCGSYDGNATVLYEDKILDLIEGPETEIKGVDLLNGNRRDNYIALSTRGKTVWVCKLNDKIEIDSILEDHTQDVKGVKFFNNLLYTYGYDNTVKVYQRFTMYDDSWVLLQSLEAQKETVWDVEMLTKLFVASNDGCIYVYRKEKDWVFDYCCNISVYPILSLCRIRDFLALAVDSKSLVIVDESLQVKCSLEDAHQKDINCVKYSDDNNMLVTCSDDGCLKVYHVDFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZI4</accession>
    <name>L7JZI4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993809">
        <property type="protein sequence ID" value="ELQ76873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0132"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZI4"/>
    <dbReference type="OrthoDB" id="583456at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="939" mass="109634" checksum="F38531B286558107" modified="2013-03-06" version="1">MWSNLYKYIDAGLKYIFLFENEDDFATENFIITENPEDLQMPGLWTVKQRTEMVQSITNENGINIFGNNKLVENLFSHDHAYYYNYAAGIRKIFYQTHQDVIDKNTNIQFKVINVPMSFSLYAKIIKLSIHCTVSFTIREIREILKHYTRFEKNIMILLLKHVCEHFLKDKTLLQKIQMYRDHPSDDPNTSSIMSIFLPFFDTEEAIYQFKMLVRLHIVLLISNGNKICPKLCSRSLLCQHQALCANHDAFALLFFFDKLEIYYEWFINNKNLLDTVFKCNMIDSSYAVSIYGSMEKYDSISDANVCKEILDLIQTSEFLQGTVVSELTLEFDSIHENVEIACLASIRASITAQCTECSLDFIQSIPEYIKITVSMDNLFSTPPFNISHNVTNMSFNNCNFDYSLRIPNNVESVYISDCTFNTNETLTLSERCKNVQISSSKLTFIFPNVIEFDMRSNTERNFFLFEFKINRMSEKEALLLDTAIIYKTISIDRSIESLAFVFVTIVPESCVTFNEATKYLTISQSEGLFDMRPYIGVMQHFKRNMTMKISPLKTSLHKLSEIILLDFELTETVQLSNIYESVVLNRVFMTENTEIILNKACKKLEINNSTVVINAWNVETIEHLFVRFSLKGNSFVKFVGLRRVNYVHLFNICLNVNSFATWLTGFESIKHLIFDNNHCLDDYHLIDAYYKNLMSFISTKESLERNPGLLRDVLAVRENKVTVLVYRRSNIIINYYLKHILNCEVMKKVSKLEFIGIAINSSNCNSFRNLKNLKALQLSLEKIDNKFLYNLPPNLKLLRVTDLFNENLNLRSEYTIKPSIIVQPHINLKILSVHVDFLYNLCFMAVSMPPLEILEVQYSRKIKIHSRVRKFKIKVRELFVQCKSYKQTYDHEITLTQNEMISFMKSIESHVEFEFLECVDFVFWGASVIFDPKTLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZJ2</accession>
    <name>L7JZJ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993807">
        <property type="protein sequence ID" value="ELQ76883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZJ2"/>
    <dbReference type="STRING" id="72359.L7JZJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0124"/>
    <dbReference type="HOGENOM" id="CLU_1086229_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZJ2"/>
    <dbReference type="OMA" id="NANNYHW"/>
    <dbReference type="OrthoDB" id="10341783at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="278" mass="31224" checksum="89F5101AD26AD8CC" modified="2013-03-06" version="1">MSSFNANNYHWLEENISPFCTDRLKALLAQKRYELTDLNLTMHITVRMNQIGFIYDISCTMERDGMCTMIKEFDNYSTGSDVHGPGRDDFLVALECVKKDAMEKYGGVVAGGKVVVEKIGADLVVDRTKMNEWCDGNSRKTGDGEENAPHADGSDENVRGLTVKMTITLACTKDDLLNYLFNPVFYKQYAPKSSGRCVRVVENVSFSNLDKEGMSFNVSMPDLLPCSKVQLTLKETESGTEVFMEQSGVIEGGEERISAFWKKYFFPKLGLHFNCAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZQ2</accession>
    <name>L7JZQ2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Preautophagosomal structure membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0224"/>
    <dbReference type="HOGENOM" id="CLU_556894_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZQ2"/>
    <dbReference type="OMA" id="CPLRVYL"/>
    <dbReference type="OrthoDB" id="2192796at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="490" mass="57687" checksum="F72F02EAF536B276" modified="2013-03-06" version="1">MHSIHSMHKQNKKQNKNSHKREKTMNTRLNASYFDTESSEVHYLSERLGTIEQNTRTCMRQFVARISATQLIKLTYNYYTCPLRVYLFTKASKVLSMVLFITLFSITVNYLRTFGEKAFRVVLVTRWMVVAITAVLLYQGVFLVHAVRNRYRGYLIFRYVYRFGPRVGFARITRCIQRVLDRHYDVKITSGRIKRIISFEDDLYAHLVRAGTVTNAFYTALLERLVQHLFPLDRHTITCTEHSHRKRTNYLVIAGLALCAPIMCMLLFISRTVDMIRTGSSLSHAFAYDYAPLSVVRLRRYGVLPHVYRTAVQRSRKHAQRMLRSYEHGVAHVLAKCVLIVCSTVIFVLMLVLLKMFVYQRGILSLEIVQYRLELQITRHTALVLKLIDIVYIVGFVFYLKNGVDVRAGRVHSTRRAFRRWSKALRMSKYQYDGSLRTLIRGMMMRRIVLVLRECAAPFVVPWQLLRINARIERFYERARRSFVFRRAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K054</accession>
    <name>L7K054_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K054"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0417"/>
    <dbReference type="HOGENOM" id="CLU_874885_0_0_1"/>
    <dbReference type="InParanoid" id="L7K054"/>
    <dbReference type="OMA" id="CAICTRI"/>
    <dbReference type="OrthoDB" id="2194095at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="318" mass="36754" checksum="38377790D986538D" modified="2013-03-06" version="1">MYCIINMTRHGSSKHCIRAFASSLYAIPVFNTKLHSFVKMPSMVSFECLTPLLKIVTHEKSYKIQLLTVESHQTILNIFKHIGLVYRVTYRSMKNTFNLVYTNKLINVVINDTENDVFEYDAGACFILIGGCVVHGLLHVVFTFKQDEACEYLREMHLDEQYYMNEKNNKAKTLQGKKKGVLKRNTHPVDEQKTVCNAEIDLLIKKYYKFYTLTQLSSQMKPSKQQIIPDLSWLESALIFSLCYFKKFGDILRNIQKMNNEENNSFKILMALNKLVKYGFVKKRAGSYSLMLSKEGACAICTRIGYDLKKETEINGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7K075</accession>
    <name>L7K075_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exopolyphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.11" evidence="1"/>
    <dbReference type="EMBL" id="JH993817">
        <property type="protein sequence ID" value="ELQ76756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K075"/>
    <dbReference type="STRING" id="72359.L7K075"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0249"/>
    <dbReference type="HOGENOM" id="CLU_2225032_0_0_1"/>
    <dbReference type="InParanoid" id="L7K075"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="106" mass="12122" checksum="AA1C7DFEE24BBD7E" modified="2013-03-06" version="1">MGKSKKLMDFDKFLKENKKKITHSELKIALGNEGCDLDSFLGSLVLAYSQNVVHVVNMRKKVFKCKGELMWVCKHLKISVDDLIFLERPMGNFYTACTQGRHVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0D8</accession>
    <name>L7K0D8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0D8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0070"/>
    <dbReference type="HOGENOM" id="CLU_617059_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0D8"/>
    <dbReference type="OMA" id="GYNELWT"/>
    <dbReference type="OrthoDB" id="10369937at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="440" mass="51365" checksum="1035DC4F841608ED" modified="2013-03-06" version="1">MKDDEEPFTKSCSIPPEKNDEDFQTTIRMLKKELVTKHAASYAAEIVAHYIYIKEYENALLQYEDINVSSDELDRMKLFIEVHLMNVDRRTCTATDGHLVANCIPYGLNSFKCQRAKRKGRPKQKLKFGFRKGPRRQQQRGKTVSNLLRYSKVTVNVMENNTAEVQFTRDVDSNLHMKIDNSGMADEASFVSAYENKSAIDAHDSEVQAQQTNFSMVINLDTSIIDLKRVFWDKSMDMARKTKFIIENKLYVHSLFNKLEPATQLGYLGAVISLTEDKLINFLERKFDLEVFSFLGTYRATTRRFVKDDCLERLKFMLNEEYCKELGYNELWTMYTVFRDDRLLRRAVYKNPFASDRIVSLGFGKEVRNGGSAETLEKVCRVLEINWFKCLYVWVEKYGMVNRLMRETRAHKTKALCAIVNNRTKPSDQIKLEITKKTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0E1</accession>
    <name>L7K0E1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993803">
        <property type="protein sequence ID" value="ELQ76941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0E1"/>
    <dbReference type="FunCoup" id="L7K0E1">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0E1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0065"/>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0E1"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="230" mass="26964" checksum="12515A84E8A4EFB3" modified="2013-03-06" version="1">MLFRLVRCLQNYRSTDLKIFNISSLAMGAKDYLQAFRRNKQSDVCRYLSRIRMWEYRQRPAVHRAERPTYPDKARMIGYKRKSGIYVFRVRVKRGGRPRKADGGKTNGKPSKSGIYHRKPTKNLQGLGEIRLGRKLGNLRVLGSYWVCEDRQYKIFEAVVIDPMNKTIRNDGKYNWMCKSNMKHRECRGLTAATRRSRGLGKGYRFAQTAGGSRKAAWRNRNTVSLKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0E5</accession>
    <name>L7K0E5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
            <ecNumber evidence="2">1.5.1.7</ecNumber>
            <ecNumber evidence="2">1.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.5.1.7" evidence="2"/>
    <dbReference type="EC" id="1.5.1.9" evidence="2"/>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0E5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0049"/>
    <dbReference type="HOGENOM" id="CLU_1442013_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0E5"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047131">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="188" mass="21558" checksum="A235820C585D8FE6" modified="2013-03-06" version="1">MCYCVIFMGTDHSVVTRSQKAFHENNDEPVVDFYIYMEVGGLFGVIIFMFFFTIIFWLARSKLGRKVLLKYPGFFTCGRVKHGLTNEEINKSSFEMNLYGYYEVQDNMSGQGENAERQMEHLSVTGPDPGYKTTPICMVECAIYLHDRICNSQKFTLCDGGVVTPAMLFYDTELVNKLSDEGIVFTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0G8</accession>
    <name>L7K0G8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative WD40/YVTN repeat-like domain, LisH dimerization motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0G8"/>
    <dbReference type="STRING" id="72359.L7K0G8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0428"/>
    <dbReference type="HOGENOM" id="CLU_573756_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0G8"/>
    <dbReference type="OMA" id="MDASICV"/>
    <dbReference type="OrthoDB" id="14421at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="560" mass="65085" checksum="0D24F43A605A2155" modified="2013-03-06" version="1">MSDYQNQSNSQSSTPQSLLNVLIHEYLTKNNFPQTAMTFKNEAGIAEYADTTSNSVLLEWFRMFNEICMVRSGSTSDFENLARIEAIMLRLENEKMRYYNVTKDKNFDNDKMRMLPMMRRQPRYGREQEVRYPVPPRFNERRPQRNDYASDDFRREYEDYRRMSAFSERDMRQGDARAEMRGMEMREGMRTDTRDVTFRDPVRPELKYDPREAMRDNPPTPGNNYGYNSLINLNLETRRQSAPDSKFEDVKETKKVYQNSLKEINSFFFDQKISCSASTNNLLFVALSDRTVQIINLLSMKIVGSFEPHAKPVVEIKVLVLNDESLFEHKSMDEQSVSGGETGEKVLLCTNSREKEIKVFRASDDGSMSNVCAVLPRNVAFTSALTKDWVYTVDLDGEFCKFDITGALKERVMMDEGVKQLVHYKDDLFIVNTRERVHVYDYAKRESIRDLSNEPALLIVHYNDLFALLHRDMVVIFGSDLKRLNAISVVNRMNSLAVLDENNVFVGVYRQIYWHSFNSLITNEKHSGTITALEICNLFGRTVIISMSQTGECKVWEISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0K3</accession>
    <name>L7K0K3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside phosphatase</fullName>
            <ecNumber evidence="5">3.6.1.15</ecNumber>
            <ecNumber evidence="5">3.6.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="5"/>
    <dbReference type="EC" id="3.6.1.5" evidence="5"/>
    <dbReference type="EMBL" id="JH993807">
        <property type="protein sequence ID" value="ELQ76882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0K3"/>
    <dbReference type="STRING" id="72359.L7K0K3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0123"/>
    <dbReference type="HOGENOM" id="CLU_564061_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0K3"/>
    <dbReference type="OMA" id="RMIDDKN"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004050">
        <property type="term" value="F:apyrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF127">
        <property type="entry name" value="NTPASE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="496" mass="57017" checksum="BB5939F473364B4E" modified="2013-03-06" version="1">MFQHALKLQTKRNLQMLLFAPFILAKQFVVILDAGFTSTKLNVYTFSDMIVVSSYTRFYHPGVHELRMNEIEHMIECMLSDARKFVEENGGDVHRTRIALVATEGLRSLGRTCADVILRCIKGLIDRSGFVSGRHSVSVMDGVFEGLYAYEALVYLLFLRDNKDILGEQLVDRYRKNKTRRDDEVGRSDRNAVRVSKNWWNEKKNNGQSTENRDKKTASDNTQDNITDSSNKLTHENRTAVISKVGQQEETGDAKTGKKKLHGWYFFKAKSGENTSKNNLNELKNTEENEFDKVTYLKPRNNTTSSIKSENYLQREHSTTSHSLTTNSKLSLGIIEMGGGSMQIAFSTNVGNKYQLFIHSFHNLGLIKGMNELLSLNLLERCRDLKDECVHCIREHFNLNEFVRAAPLHSVHKFYLLSFFYDRLSEYQPIRKFDDIINVYKTRCVRRTKNCNDLEYMVLVLKGIGLKGDTRVEIGRMIDDKNLNWGLAKALEMLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQS1</accession>
    <name>L7JQS1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3282"/>
    <dbReference type="HOGENOM" id="CLU_1533736_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQS1"/>
    <dbReference type="OMA" id="LCFHIMA"/>
    <dbReference type="OrthoDB" id="2189089at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="183" mass="21331" checksum="6ADAC398F54E20F3" modified="2013-03-06" version="1">MKFKELVFTPITIFIAFSVSSMLFFGSYMQPMTTFFKTSLNIHDDKTLCFHIMALGNFMTIVSVFIMARAARILEIEKLQRRIRKSALNLVPLMFLTFSNVLCAYIFKVGEDVMLRVVMCLAATHLLYFYFSIISSSLLTLYVESLIFCFNILLLSATFYEDMGRMTFSRNMFSRFFEKLVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRC0</accession>
    <name>L7JRC0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin complex component, TCP-1 gamma subunit (CCT3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRC0"/>
    <dbReference type="FunCoup" id="L7JRC0">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3265"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="InParanoid" id="L7JRC0"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ73825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="520" mass="57706" checksum="266F09C3CD74599E" modified="2013-03-06" version="1">MQSVPKSLNCILLVKDKSIQVQCDNIEAVNTISSILTTCLGPRSMQKMILTRIGTIQITNDGNAILRELDITHPAAKQIVELARTQDNEVGDGTTTVILLAAKLLEEMGVLLRDKIHPVHICKILKEALGECLSYLEEVSYPFKGSEDEKIGIVRHSVANKLCTMLKVDLASLAYKAANIAKNCDIKTFVKIEKISAADFSGCDVLDGVIVNKSLIHSEMRREIRDPRVIILDTPIEYKKGESKTSYELKNQAEYTRALEIEEEQVQEVVDHILALNPDIVITEKGICDSALSMFQKKNVTALRRFKKTDTLRIAAVTGATIVSRAEDLEEKHVGRNCRLFKVTRLGNEDYVNFVECVDPKACSVVLRGPSRDILNEFERNFEDAIKVARNLRMSDRLCAGGGATEMNLCKFLLRSSETTENTRNSTLRKRVYDGIANALRMIPLTLAKNSGCDDPLGLIAELESTNDVYMGIDGVNGKVVDVRNLVMEPIAVKRQALKSAFEAVALLLRVDGVIQSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRC4</accession>
    <name>L7JRC4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative CAAX amino terminal protease self-immunity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3051"/>
    <dbReference type="HOGENOM" id="CLU_1152484_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRC4"/>
    <dbReference type="OMA" id="SAVFMHI"/>
    <dbReference type="OrthoDB" id="10348683at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="212" mass="24695" checksum="6739655CEB23EE81" modified="2013-03-06" version="1" fragment="single">VLLIQESIGKKINTIFMILEDFSLYSCSFLVYFLYNNMLKTDFKKTWLYKYRLCAIICFDIVLSQYFVFIGNLKIPLIANNGQSDSASVGDVAKLARIFTLVIFGPFLEEIIFRRFLYQLVKGDRRLTKAIRNSEWRNIFCLVILITINSTLFALLHYDEHYVHFFPWPFLYFACGGVNLCLACELCDNIVSAVFMHIFFNFFVLVKAIVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRE2</accession>
    <name>L7JRE2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3225"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRE2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="940" mass="109234" checksum="0DCC39FCCBE55E19" modified="2013-03-06" version="1">MLFNLYDYVNVAVIYVLVFEPNLDEENVTSIEVYNLNDTKIRQFFKCAEIKSSRTSYDDVRHHSKEHTAQIFKQQGTSSQFNTPFSLEKTEETELSQSTGSNIMPAKGVTAQKYVYKMPFSFKLYERAILKKNGDPYRFSANDIHCIFKYIFIHIEYDKWLTYAILRSLQDEPSIFFCLSESSREYKLNMLRIRPNNVNKPHNFDEALFKFRASVNYNIAVCLTVDGREIATVGGKNRNENTIQHEISLPDLKIGFIFEQLEVHIDNFKKYINLFYKKFRYNGYNSKLTIIISGNLSFNTMLDVMVNKTVPDNAFEWLLEHKILHEEELEQVALKMTAANVSPDTLTNNIFPRNVYLIQCSICLLNRNGPPIQDIGINFMRYLYPDINDILQDITRLYCQNITINENFYVKKRFKYIQWRDSMIEEGFTVTFEVECETLDIKRTTGLFNLAGMMGLYQVWLTVIESSLCFSVDNQKATSCLTLKHVQITDNITIDSRTTQITFEHVESDFNIALEITDNHKLINIRRSIGEYEFKGNLKLRSRFNVNTILTIKSDKVYRTKFFLMNCDFNVSATLSKIYGCVELRNILIGKDFCFKVNENCEKLMILQCTGLFDLSNVDRLEILEINFSNQWTKKLRIIGPISVKHLTLINLPKDLIILTQFFNELVSIQCLTIGCSSLRLLATNLETYFCSINLKSICQKYQHYTNTATAENAQTSEKEHPTLTSCKFLSVIFHAPALVEVERLEYQKIYMSNHNCEYLLSLRKLKMLKVYMENLGNETFIYLPQNIEYLNIQASLFTDYYLKSPPNSLRELSNLKVFVVSGNVFFNLTISNYLPPSLNVLVVSYFLLKNNFSGDSNIVKIRPCRLYISALQDLIIDIETGLPHSDVHNFLDALFNYVEREHLELLVLATTSSCYEIDVLTFRTVNHFPKKFDFGIGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRJ1</accession>
    <name>L7JRJ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3183"/>
    <dbReference type="HOGENOM" id="CLU_543138_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRJ1"/>
    <dbReference type="OrthoDB" id="10614527at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="502" mass="54920" checksum="7CEFE681513E05FC" modified="2013-03-06" version="1">MIIGLFFKILGVILFIGIIFVIFLWVKVKQFPLVIKSKDKNLPFAIGEEDKGGEGEGEGGDAEKGEGGDKGGEGKTELKGRHVKNTTDSLNMLNNHSAQTYGSMAYPMSSGKDSNANTLLSSEKGTRHDQSSKDITSNYLANQPRNAGDRFMSGNNLLGDPAEYNNMNNYLYNPMGAYDNLYNTSSPGNNYLMSFGQGINESGLANGYDKPDLSFKPNNVNLADKSDAKKGKKEEKSADSKKEKEELISPLNANLTAKEDESDAKKGKKKEKSADSKKEKEELISPLNANLTAKKNAMVNLAEANEVDMKKDTKEMLQEPGNANLTEEKDKKKKKKSSKDNENDLVGVTNVQDVNLKEKGQKALPDVQKSNLSAKEDDESEKNEKKNKKKDSKLKPKASKLKEKLSGNNLNEEKESKIASSNVAADKSSLASSSKKDTEDDKETKHHKDSHHNGESHHDEKLSDPGNLLDTSNLFGNEDNFGSMGDNGSALLGHKSFSNILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRL1</accession>
    <name>L7JRL1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3021"/>
    <dbReference type="HOGENOM" id="CLU_1526324_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRL1"/>
    <dbReference type="OMA" id="NRICLEM"/>
    <dbReference type="OrthoDB" id="10507119at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="195" mass="22842" checksum="B029A564F3955133" modified="2013-03-06" version="1">MMVLNNEIIISQNIGFENTNRLISYRSFVREVLLTNLLFTLRIPSRHIRGYIFLSQLEYVHMYIIVSKCSISGNKEFKNVYDILFMTLPDFGLKLSFASKHVLGTWDQAITFNGIRTNYIIVEMICQQPGVFKRALRKNVLRIFNQKTFRFSGLSKLKETICNHIDKLDERDPCLMAPKAHAIYKFIRLRLLENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS71</accession>
    <name>L7JS71_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2766"/>
    <dbReference type="HOGENOM" id="CLU_2943464_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS71"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="6735" checksum="FC9A7435D9CC2875" modified="2013-03-06" version="1">MRSCQELNICDPREEEFLGVLLRGECHASHDLRVKVTAAAAAYLSVVMRMHAKALRKTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSF6</accession>
    <name>L7JSF6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994093">
        <property type="protein sequence ID" value="ELQ73986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3101"/>
    <dbReference type="HOGENOM" id="CLU_708970_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSF6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="390" mass="43530" checksum="E9E0E4791230182B" modified="2013-03-06" version="1" fragment="single">VDSSQIHVDAVNTRSLKAITIINSTSIVYDPSIHLSLSYLSISMMNIGLNLDLVPGLDTFLLTDSILAPGIAIKVNENISYLSLCNSVGIIDMKGVAGLGIIEFKPKHALRLDRHTGGNDGGLLYIENYTFEHNIAVSNDIQTIHLKNVKAKKGVKLILAQGCKSLKLDSSWVAVDTSQATFLEKLTLKNMKLLISENLLVVPSTIKTLVLLNTVITGSCTLPIHIRTVVLREVKLANSSILKFNQECRKVRFYHCSGEYDLSGIQKLEVLGLVPELKGTLELKVCLPSLDNVRKLDIAYNLNEDCLESCLARYINLESLTVRSIDYREKCLPYPQLSLVKSDVFNPSNMNAWLIQKISEYELPREHLDNETANLLNIKMNIFFKRALYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSI2</accession>
    <name>L7JSI2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSI2"/>
    <dbReference type="STRING" id="72359.L7JSI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2687"/>
    <dbReference type="HOGENOM" id="CLU_117799_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSI2"/>
    <dbReference type="OMA" id="NDLMACP"/>
    <dbReference type="OrthoDB" id="10329775at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="16566" checksum="6A0A8391A3A31A62" modified="2013-03-06" version="1">MDYYNVDLLLALTNKVAVTFTPPATLLVPATKTTTTLTTATLPIYQTLFFLKNGHCVQYGPLVPSTVVNDLMACPVLVNLNKLYRHIYQLVGIVGEEGWTDIFKIRMGMLSKLLFVENFCEDDLLVCDENEREIVRKGIIRFKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSM5</accession>
    <name>L7JSM5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994052">
        <property type="protein sequence ID" value="ELQ74295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2784"/>
    <dbReference type="HOGENOM" id="CLU_1210533_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSM5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="229" mass="26302" checksum="239A440C9ECE59F2" modified="2013-03-06" version="1">MIPMFFSRNLRVEKAYQLSSLYLYANPLDAIEVRDNKHTRRHVFSRMLTDASTRMSNIYPNDHSFRFEATSNLISSPTVIGKLYVSIRDGDKWVYQTAPVLDHLRIFAARFHETLTGGMMSRGRFLEMMAMEVIFMEYLIKRTGDANMLSSGPVGQFLRRHMCADAIPLYQVDEIIPGLCAGSDLRVSVHNANRRVFQLLADCATQSRSGPARRHRLRDRHARDCTDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSR4</accession>
    <name>L7JSR4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994039">
        <property type="protein sequence ID" value="ELQ74469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2616"/>
    <dbReference type="HOGENOM" id="CLU_166246_3_2_1"/>
    <dbReference type="InParanoid" id="L7JSR4"/>
    <dbReference type="OMA" id="RATKGTY"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7812" checksum="7CD1E5A3731340BB" modified="2013-03-06" version="1">MVRATKGTYIKTEMSIKEVIMFINETDNIVIEEIKDNAVFIQLNKTDMLKRKIEHILNSTYKHIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSU9</accession>
    <name>L7JSU9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2466"/>
    <dbReference type="HOGENOM" id="CLU_2504103_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSU9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="86" mass="10228" checksum="5BDC6E253A8FC46D" modified="2013-03-06" version="1" fragment="single">VFLLKFIMFFVVTPMDHLTPSIQKLRNLNVKELRSDNVMIGDEKVENTLCYKNYFERVRGNKLETINDDISLGEYGMRFTYEKDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSV4</accession>
    <name>L7JSV4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RuvB-like helicase</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JSV4">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2682"/>
    <dbReference type="HOGENOM" id="CLU_509590_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSV4"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="101"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="535" mass="59754" checksum="3E1C07F789F9590E" modified="2013-03-06" version="1" fragment="single">VSLLKNPLPFLRWPSQINLALLAIFASAPLFGPFSPQNKSILNLQPMFADQHSTSSPHSHISSLGLENLEPIDTKNAILGQKNARKAAGIIIHMLRTNKMSGRAVLLLGPSSCGKTALAMAMSKEISSNFVHLSGCELSVEDLMMHVRRAIRVKLRELKKVYEGEITSIRLTNLQFEIDLKSCKGSTTVKMGKSMYESVRDEELSIGDVVYIEPMCGIIKKVGRSENAFEYDIERGKKVPLPKKDVLRTKVVTQILSLHDIDVAEDTSDQLKNTVRHVLGKNAVSIGTMHDTNEIVNAYVENGMGDVQPGILFIDECHLLSTHVLFQIIKAIEGDVCPLVLLATNSRQFLERQDAQDLFNRLFVIKMEKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFKRMIITLFTFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSZ6</accession>
    <name>L7JSZ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2467"/>
    <dbReference type="HOGENOM" id="CLU_2980755_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSZ6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="6644" checksum="97484E761B0E3053" modified="2013-03-06" version="1">MSFWKCGITNIAGIKIADDVVVNGINFVLVREKKLRNFWMSCIFEGYLSFIKGKLNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT20</accession>
    <name>L7JT20_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3180"/>
    <dbReference type="HOGENOM" id="CLU_1058406_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT20"/>
    <dbReference type="OMA" id="WITHDIL"/>
    <dbReference type="OrthoDB" id="10454170at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="238" mass="27203" checksum="6DC8CFD40698EE6B" modified="2013-03-06" version="1">MEKKIIITITIIGTVVLLFILLLCMSYSMLQAVDNKYKAMVDKKLKESAKIRNEFMNGSHPKEYFMVIGSRVTDQKKELGLVTKLINFDCSQIIHDLDNNDECKLNYHTFAIMQGTGSLPSKINWITHDILRKHQLLYNENFLVRMASKLFRSFSVCIVDRQIRFLQQSAPKDKRNVFVAVSMDSNRKVYQLHVDDKKKTLKLNDQISIVVDKHDALAVTYGVLSVLEAAGFGKPGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT28</accession>
    <name>L7JT28_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2904"/>
    <dbReference type="HOGENOM" id="CLU_1679198_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT28"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18158" checksum="EBD14A24A16CC933" modified="2013-03-06" version="1">MFLLIYHVIVVIAADIMDCIASQRLLNNKAMKRRRETSPFEISFGNGAKQKYITSGSLQLNEQTNSEITNECEQAVKNTYCEGYNNSNILNKNGHEDMHTLHRKNSESITHHKNIPNDRYAWFGERNALLTQKQNKQEDVDTCRIENCYISTQNESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTG3</accession>
    <name>L7JTG3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994046">
        <property type="protein sequence ID" value="ELQ74336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2744"/>
    <dbReference type="HOGENOM" id="CLU_2591476_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTG3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="80" mass="9244" checksum="04D91993EFEBE131" modified="2013-03-06" version="1">MNSLDRITHRNTNGPHGEQAIVSNSFEAHNKKIIEQDNKRARVETPKRKIEEVVAPTKTKKKKKADVRRTSQAAQRWNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTH9</accession>
    <name>L7JTH9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2297"/>
    <dbReference type="HOGENOM" id="CLU_861032_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTH9"/>
    <dbReference type="OMA" id="EQISANM"/>
    <dbReference type="OrthoDB" id="10546489at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="323" mass="36834" checksum="C8E14C6359A97D73" modified="2013-03-06" version="1">MQFVCQYILIMCIQATNPNVPRFWRKENVHTPNQAMNLPSLRPVTDRLNKTPTQAELLEQISANMQVYAENTERFMSSIYQSREHVDSSGTRRRYLESKVIPQVSVPAVSSNSMQLQSEISSSDQSGNVSRSTNVVSLLKTTATATLTAPGYDLARKMAASLKKHIKLEYKPVYDKIWCDTHSSSDVDELLISTLQNDVFFDIAYIFIIVTKEYKRFLSEITKIHYLVHEINPRNGNNIYCLLALLSALKPFYHIVMCVLEIFVRMNNGEHRLTRAMIELVRSLFKMVNAIDSTANDLEKKAILQQHKGDLALLSLLIPELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTK5</accession>
    <name>L7JTK5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2337"/>
    <dbReference type="HOGENOM" id="CLU_1448689_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTK5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012429494" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21785" checksum="4198DCA7FA5E6866" modified="2013-03-06" version="1">MLFFICLLINSLVYATQPSMHRVDISRIEASEGEDISNKPPEVVEGMCLKWDAARLMKTFKRLCHESIKMFSDFQMHVQKRYKDERVQGFLVLIGNQNECKSTSPADPNIPKNNLNKENLSVFYKKTQDAFDKLLEEYVSKDPESNILNNSKNFVYPETLITRLSPSRIRYGFMPIPSYSYHGIFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTN3</accession>
    <name>L7JTN3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15 7">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTN3"/>
    <dbReference type="FunCoup" id="L7JTN3">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2232"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="L7JTN3"/>
    <dbReference type="OMA" id="NSWISHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 7 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="11">
        <location>
            <begin position="122"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="9">
        <location>
            <begin position="452"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="9">
        <location>
            <begin position="601"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="10">
        <location>
            <begin position="827"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="914" mass="103203" checksum="E71EFD67846D080C" modified="2013-03-06" version="1">MIRVGGSDKGSDKDGVNDKYGVNKGIEGGNEGGSDKDGVNDNTPTINTSTNTSITTPTINTNPTNTTNSYPLNTPIKRTLTAAEVLKKLRFNIDKCAELFLATGTLKIRTNDLLQTTGLSILAERINTYRFLSHFESINRGAFFAVLKTTGVRALRPESFGFLCPVHTPDGAPCGLIVHMAMDAIVGRDEELKIAGCVMGDRPLIVDGRVVGYVDGWFGEYLRRRRRMEGWCVEIVDRWDAVYVFGGAGRLMRRVVDGGVEVYVGVMEQVDAVVLGYEDDCSRGRESNNGEDDCSRGREGKGRESRNREGNNGESRDRESNNGEDDCIGESNNGDSDCGRKDRDIAHKQNKNKNKNNLKNVNAHKNERYKRNENNNSRGKNTEHSYDNDHSNVINKISEGINNTSINNTNTKNNIDNNIKGTSINNTNTKNIKNIKMPVYKERPNARFFSYVASTIPFADYNQSPRNMYQCQMAKQAMAYPTLTYNNRTDSKYYVLNNMQRPLIKTFLDTLLGTNVYIAVLSYTSYDMEDAMVINKCAIERGLFDGYVYVTKVIERTHALVLPDVGEELTHGCVLYVKDGESVPYTGECARVHCVRLTDALAIITLRVRRSPQIGDKFCSRHGQKGVLSYRYRAVDLPFNEHGMVPDLIINPHAFPSRMTVGMMMEMLAGTVAVIKGERYACPPFKTYGVKNEHDVENDLGRNIKNDLSRNVKNYLDKNVENDLGRNIKNDLDRNVENDLHKNVKHRMNNHTHEHFCEQLRALGLNYYGNETLYSGITGHKLHARVFTGMCYYQRLRHMVSDKWQVRSVGPVQAQTRQPIKGRKRGGGVRFGEMERDALIAHGCAYLLYDRLMECSDKTAFEYCERCKTFLFVRDGTCLCGCRCVKVVYLPYVFKYLCTELMGMNIFVEVDVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTR7</accession>
    <name>L7JTR7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2180"/>
    <dbReference type="HOGENOM" id="CLU_842470_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTR7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="330" mass="38118" checksum="436A520B19E2C66F" modified="2013-03-06" version="1">MNIYFIYCLQILALGHKKSGINEGTSKSTVINFNNNAYDLGNSTDISKWVKDFFQSLNVMFLAYQTVNELYIRPTVDIRRLCVVLSLLVGEFNKLTGLASMYSSYEQIESIYTSFCDIVTYIDRHRSELIPFDSEKLWHWDIACQLCEKTVDFLVLVTVLSKIWKLPVEIVNVKTRHIYLPEGDRLCQMKENQLVFKNEDIKRYINKEIGVVHNLVLSLKTYFDTLGCQIYEDMEAMHRAIQELGQNSPSKSELLKYSFSKLYYDQKKKFYDAVENSRALLNELQATSGVSFCAAVDFPLCEENLPIVLKLANETNKNEKPNSYDASKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTW8</accession>
    <name>L7JTW8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">20S proteasome, regulatory subunit alpha type PSMA1/PRE5</fullName>
            <ecNumber evidence="2">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="2"/>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTW8"/>
    <dbReference type="STRING" id="72359.L7JTW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2910"/>
    <dbReference type="HOGENOM" id="CLU_035750_8_1_1"/>
    <dbReference type="InParanoid" id="L7JTW8"/>
    <dbReference type="OMA" id="MSSKERY"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="230" mass="25737" checksum="3ECF72DB9F991D5A" modified="2013-03-06" version="1">MSTYTEYAGVSIYAPDGKVSALSHVQQSISLGSTALCITNHKQSILLCHHHSTSKLQHAMRKVFVRKNLFFTFSGITNDGLELIRYILDEMSTQNVWKNTAIDPMRAFNEISVSASARTLISSDRLYGCGGILGVEYRGKIKVVEWMPTGTIRSAKAVAIGNRAQSCRTVLEKYFEENRNVSNEDMLDLAMSAMRNAHGQDGEMKRENLEGYILKLGEHVKPIEDLGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTZ9</accession>
    <name>L7JTZ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2145"/>
    <dbReference type="HOGENOM" id="CLU_3244858_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTZ9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="43" mass="5050" checksum="8DEF2BC4008DE54B" modified="2013-03-06" version="1" fragment="single">VLIMDGCNRLYKCSMRVTLLVRRNDIKEIYLSVVMPLLLHINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU95</accession>
    <name>L7JU95_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2760"/>
    <dbReference type="HOGENOM" id="CLU_2741838_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU95"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8425" checksum="A93E8F3F5ABEB9F7" modified="2013-03-06" version="1">MKPSNWKKYNKVCIFGSRSERSLISSVENQKTIDLSMDNSEWEQNEFPKILRKLEEAKEKKIQTLYLKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUG1</accession>
    <name>L7JUG1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">20S proteasome, regulatory subunit alpha type PSMA4/PRE9</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUG1"/>
    <dbReference type="FunCoup" id="L7JUG1">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1952"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_3_1"/>
    <dbReference type="InParanoid" id="L7JUG1"/>
    <dbReference type="OMA" id="RECFKVV"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="3">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="302" mass="34053" checksum="87987FCB6B7FFA01" modified="2013-03-06" version="1">MRVFKSLSMLCTSFCPSPSCARLYLLLTRVLLSLAFLRTSSSPSHCYARLLVLLMHLFFIYSPGPCMNGGEIRTNTFNEEGRILQVEYAIKNVSNAGTTLGLTCTDGIVLLGITTTNKNHIISRNEKIYRITGSIYCTISGIFSDGLQIISMARFIAQEYLYRNGVEMSIGYLVEEVAMRMQYFTQGGGMRPFGVSFLFAQVRGDECLLYSTDPAGSCNRWRAKAFGQKEDSINNALQSNADRQFTLEEGVRECFKVVMQKQEITESNAANYEVLFITKDRSYFLKSEDVKRIIRDTKGDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUH2</accession>
    <name>L7JUH2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ74407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2673"/>
    <dbReference type="HOGENOM" id="CLU_403419_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUH2"/>
    <dbReference type="OMA" id="FMITECT"/>
    <dbReference type="OrthoDB" id="10412963at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="604"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="633"/>
            <end position="649"/>
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    </feature>
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            <begin position="459"/>
            <end position="511"/>
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    </feature>
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            <begin position="403"/>
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        </location>
    </feature>
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            <begin position="409"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ELQ74407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="682" mass="80003" checksum="3E5759AEBCEE94BD" modified="2013-03-06" version="1">MFPNLLRPSKHSKINNPCIKRFVYLCIMNCVKRRTVCTSSKKHAIKTPDPDTKGSRGRNEIKPRTRIVMAIEFIAWLMKDIVFILLFNSLVEVKINKLRKNDTKAGILRNDKHVIDNEPANCTRKINTNVDNNKKLKRGSYLYRTLYHIRAFFLTQYGILKEHFYVYHERTSIINNAMVLAVPCVKTVIFREYYPISTYLLHNVLLSLTMKVTGIPIICIFLYQQKVSHLQIYFALALLMFILEERGVAVLAQSFLVLHRFMFIIPVIVMTAHKVIENYLNRKKIQFLSLTVVVMPVIIYAVRYWLSKEQFEETDMYVIDRAVVQIRNQHGDMLEGKYEIIKVHEEDDEPAEIKEEERETSNYKIDETNNTRSDNEQNNDIKDFVKGIAGTIRSEKDDLTGKIAVDASENDKEKAVKVENKHNNEKQNTERQHNKDEEEKKRKIQKNDKGKQKHNNNPDSFIRQNELIRLKHIETSKFISSTTDKVDQKFYKIEMRDSNDQGFSLWRISSTDKNNEYIRAREFFRLKNANTNLMLGIRSDGMLNGSNESKITRQTFMITECTNHAYYKMVQDSENMLRMANEKTRAPDRVSRLNVDLSVNVADLLKFCVIVCVILFNYVLYRRYDFVCVMDDNLSMFLIFLGCNVFLSTEFFAYVQYLIVLLLTKKLIVATWNFVHTSSRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUL1</accession>
    <name>L7JUL1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUL1"/>
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    <dbReference type="HOGENOM" id="CLU_2293655_0_0_1"/>
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    <dbReference type="OMA" id="HREETEY"/>
    <dbReference type="OrthoDB" id="10391316at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="101" mass="11532" checksum="A569EE58B9A8FB4C" modified="2013-03-06" version="1">MVKPTKSGSNKNSVNSTANKTKKQGSLKPGAKDTQNKAKDTQAGLSFTKPVVNELKNLYERGEPFDKNWPEHREETEYVLKPDIKELILFWEKINEEKIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUL4</accession>
    <name>L7JUL4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_2352</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2352"/>
    <dbReference type="HOGENOM" id="CLU_000288_54_5_1"/>
    <dbReference type="InParanoid" id="L7JUL4"/>
    <dbReference type="OMA" id="MTKNPNM"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="144"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="291"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ74711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="575" mass="66171" checksum="A2FC59B38948B371" modified="2013-03-06" version="1">MKKLGGSNEDIVEKGVGKKTNGTVKFNIVDFVSDPLFECHWIDFYVDSELKTSVDVAEIKTEATKEITIGMQNNRDFEIILRGKNDVLLGMLFFACEYFMNYKNKKRVKFEFIQNATLECDMQFQRDIKLIRKNAEIICVYRDGHALENYKTITPFYCAVCNNIATFMDAYRCYKCRITCHKKCSNYILFYCVFAPEIEQAKLVKRYNIPHVLEDENASGFRYCNHCGTRIRLGEMCKVCRKCNERFHETCASFLPKSCGISLELRMKMADFNPPVQVSSKAAIKYEISDFSLVKVLGRGAFGKVMLAKKNHTLVAMKILKKEVIVNSNNIHYLDLERHILKLVSEANHPFLMKMLYCFQDEQNVYFGTEFLAGGDLFHYAATHKFTHEQIKLYVCEILLGLEFLHAKNIIYRDMKLDNVLICADGHVKIADFGLCKDNIGPDTMTYTFCGTADTIAPEVILGGGYTKDADWWSFGVVIYEMYENECPFNGSTTEEISAEILQTMPKFTENTPSEAQDLILKLLTRDPSERLGHGIVDGEEIRGHFYFKNINWNDVREKKTKPVFIPQSNLKDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUR3</accession>
    <name>L7JUR3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2305"/>
    <dbReference type="HOGENOM" id="CLU_3227279_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUR3"/>
    <dbReference type="OrthoDB" id="10424146at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5042" checksum="38D4B18D92E176BC" modified="2013-03-06" version="1" fragment="single">VIDHALKDVLSCGSRYCRKAAYEELRIDCVVMQAAKLRTRAFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUS6</accession>
    <name>L7JUS6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUS6"/>
    <dbReference type="FunCoup" id="L7JUS6">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1836"/>
    <dbReference type="HOGENOM" id="CLU_074237_5_0_1"/>
    <dbReference type="InParanoid" id="L7JUS6"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="164" mass="17632" checksum="79FC06808E5A612D" modified="2013-03-06" version="1">MAGPAIDDSIKYVSLRCVGGEVPGATLAQKVGPLGIPAKVVGEDIKKATMDYKSLKINVRLAIKDRKATIEVLPSTATLILKALNEPPRDRKKEKNIKHTGSITLVDVVEIARAMKGRSLSNEFKGTIMQVLGTCVSIGCKIEGKCPKDVLKEIRGGELRLPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUW0</accession>
    <name>L7JUW0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1916"/>
    <dbReference type="HOGENOM" id="CLU_2998127_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUW0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6743" checksum="756107E6D5AAA73B" modified="2013-03-06" version="1">MFDYSTTSKESISAHGYNKIDEEKIVNTYIQLREVNCRIHDDEENKKLSNHIMNILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUX3</accession>
    <name>L7JUX3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1822"/>
    <dbReference type="HOGENOM" id="CLU_2706555_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUX3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="8427" checksum="BEAE3834E85237FB" modified="2013-03-06" version="1">MDNDQFNEIEQNLQNVLSSLIEAFETIKEPYGGINEIKNAVESLKKVQEGLISVYENNSDENKEIKTKDNYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUZ3</accession>
    <name>L7JUZ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Centromere-associated protein NUF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUZ3"/>
    <dbReference type="FunCoup" id="L7JUZ3">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1790"/>
    <dbReference type="HOGENOM" id="CLU_025461_1_1_1"/>
    <dbReference type="InParanoid" id="L7JUZ3"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="123"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="428" mass="50541" checksum="063A1FF832462169" modified="2013-03-06" version="1">MTKEKDNIYLIPNFQPSEIISYFSEHGIPILQSEITKPSFQNVLRIYSSIIGLIYTNSSISNDADESKFLLILYKRTDMLLRRLGIDFFELKDLLTPSYKRNLNFLSTIYNFCIYRDSKKEYYEKLLLEKEEQESLLNEINVSINMAESKLKSMKDEAQKKEKENAELENKVGQLEDEVKSLCKEQRERANSVEEMKRERDEFYDKLSSLKLVCLNLKQEIKEMKTQVIDDPSKMLSLIEEMQVLIKTEKASIEEFNKKIRHTTELIDKEEEEKTRIQSAIKMAISQKNKTKTANELQNEVTCLEKTIKSLSMAINVSNRRIDHLSKQISHIEGKIEVLKKKDQENAKELSNNLNKLKDNYSKVRTERNDYFERIANNQKEIKEIEYKMVQIMNQHQKDMHVLISKLTELKNAANRYFMGFEDFNREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUZ7</accession>
    <name>L7JUZ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside-triphosphatase, RNA helicase</fullName>
            <ecNumber evidence="6">3.6.1.15</ecNumber>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.15" evidence="6"/>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="JH994013">
        <property type="protein sequence ID" value="ELQ74866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUZ7"/>
    <dbReference type="FunCoup" id="L7JUZ7">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2195"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="L7JUZ7"/>
    <dbReference type="OMA" id="NDSANSH"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="181"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="355"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="779" mass="90494" checksum="53AC0E0AB224B0CD" modified="2013-03-06" version="1">MSFDFNDEQIKMLEPHLKHLSKEIKEKVIRLLKRKEFLEVENIVSKKISVQIFNTLLEITKKMNENADLLTKRPKKKKSEKKKNEGKSTTEKSVDEEDIKADDIEVIDLDANFSKCNLEFMADAGDYAGFNEKLRLLKEKTDKMLIGPHEMDYTAEITIDENIKHRIKNKLPIHTYEDEIIRKIRENKISIIEGETGCGKTTQIPKMLLKYYKKIIISLPRRMAAINIARRVSEELCVKLGDLIGYKVRFDSNYNNKTRVLFVTDGILSLECLSDSIKQYDVIVLDEFHERKMEYDFIISYFLCKNLSKLVLMSATINSDQLTNFFNAGLVKVPIRPFSNTIYYLEKSTVSLVKNVCETISVICNETENGDILVFLPGMSDILAIEQQIRNTVVKIPKIIKLYASVSYKEQMSIFEKCDNRKVILSTNIAESSITVNNLTYVIDSGLVKKQFLRGNAESLEIVRISKSQADQRAGRVGRIAPGFVFRMYTSSEYDIMEDDLDPEIVNSDISHLLLKFMKCEMNFTLCMRLLGYQKIKLFKKSMIKLLKLGCIDKDSKITQLGEKIHKIPLKVEMSKTLLKAIDYGVFEEVAIICSVLSVKKLFYDDLEVRKSITNIMVSNSQGIGDHISYLKLFIMAFQQNFSQDFCKMYYMKRQSLIEANKILDQLKRMFKKDNEKVKISKIAKNINYERIIQAFCEGYLLNIAKKYKNFYLCIFNENEKLKIHPSSSLFDKEANLIFYERLQYTNSFYMVNCCKVQPSTLLEFKDFFRLNREKNNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUZ8</accession>
    <name>L7JUZ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ca2+-binding actin-bundling protein (Actinin), alpha chain (EF-Hand protein superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUZ8"/>
    <dbReference type="STRING" id="72359.L7JUZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2500"/>
    <dbReference type="HOGENOM" id="CLU_005217_0_2_1"/>
    <dbReference type="InParanoid" id="L7JUZ8"/>
    <dbReference type="OMA" id="LAHEFSM"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000057">
        <property type="entry name" value="Calmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="134"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="517" mass="59924" checksum="AEE7DC06BBAE28E4" modified="2013-03-06" version="1" fragment="single">VHPPIRMQNQTNDNTWVAPQVKSFTKWVNNQLQKKHYPPIMSIVDDFCDGKTLINLLNVIYDEPIEHNKGKLSEFQRRDNIDKAIKFIESKNIDLVSIDADHIFNKNVKLTLGMTWALILRSISQYGCDDASSKNIRSILLKWCRDCTKEYDNVDIKDFTHSWKDGLSFNAIIHHFAPHLVDYYSLSGKNAKENLTNAFDVAEKNFNIPKLLDPEDLTESVVPDEKSVITYVSQYYLKLAELEYKSNIEKGEEHLAKMDEWLRKNMGGYNKLAHEFSMLLQRKNEAETRLHGALAEILQFDASNNLHEKFLKLSSLYGNLRMAFSVLRGKEFETMPEYEPNNLMNRMKETTDMLSRTRIKLKDIAQSIELNSDTLAYVDKNKELLCKKYNSQKDDGVKAITERIACKKENNLSSTVGKLCEEKLALLKDLDRHKEYENYRLETAIKLFKTYDSSDTKYIDEVNFNNCCFVLNLDTDRDVIDGRIHYDDYVQFVKESLKKLSIKSGMACENVTGSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV10</accession>
    <name>L7JV10_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993980">
        <property type="protein sequence ID" value="ELQ75244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1815"/>
    <dbReference type="HOGENOM" id="CLU_3162571_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV10"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5750" checksum="C795C03400E5CCAA" modified="2013-03-06" version="1" fragment="single">VPNKKKRDDYLNISCSKSYNNIDNREKLEELKGKKYKDHHLRNFGALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV18</accession>
    <name>L7JV18_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993977">
        <property type="protein sequence ID" value="ELQ75254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV18"/>
    <dbReference type="STRING" id="72359.L7JV18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1802"/>
    <dbReference type="HOGENOM" id="CLU_1190617_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV18"/>
    <dbReference type="OMA" id="NDITEHY"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="233" mass="26902" checksum="943F5D287071ADA0" modified="2013-03-06" version="1">MAVKENKIVTSKYTLASFLPLNLYRQFSKYSNVFFFVTLMLLLIPAVSPFPPYAYLTAFLIVVGISIFKDGIEDLIRHKQDKHANERIIHKIMEVTNDITEHYRELDICNAAGTNFAATSSYVEDLRVGNVIILRENEEVPSDIVLLNAKVFDGKHLKCRSFCFIQTSSLDGETNLKKKQSNVNALIDPCVGTRPSSDYEMCECDKRIISNFKELRSLRRRNRFQRHKREDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV38</accession>
    <name>L7JV38_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion</fullName>
            <ecNumber evidence="5">2.7.1.67</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.1.67" evidence="5"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV38"/>
    <dbReference type="FunCoup" id="L7JV38">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2542"/>
    <dbReference type="HOGENOM" id="CLU_002446_6_1_1"/>
    <dbReference type="InParanoid" id="L7JV38"/>
    <dbReference type="OMA" id="IGMKDDK"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00893">
        <property type="entry name" value="PI4Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="569"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="847" mass="98467" checksum="A71D4D0F595B2440" modified="2013-03-06" version="1" fragment="single">VQLLNKITTPHDMKKPESLSWLYKLFNTSYFDTWKNISYLYSYPHTGIQHYLTRILRFKNAHILYLVHIMFYHCEEPISYPIMDMLVKKCKYSRSVSLKLFFTLKSYRKYLNKNQIGFYRLIIQRIMECDWYRRDKLRRTPVVEIREMKVIRDETIENSKVKYKLLEDKMVRLRNDTRIGDECEEGMLTGIKDDRSGERMLIGMKDDKSGVYEENGEGMLIGMKDDKSGVYEENGERTLIGMKDDKSGTPEGDGRTNDKVERRAMDGALERRGNIQGAYHGRERGTRTTKIDSKRKTGALRTPQKVNGRKNEHSNECERNDKCKCSYFAHKKRYMLRTRPIIDLNRGSGDLSSIFLFFCSASAFFFSEKILTSLISYEKMFYTSKSFTTIFPKRIGPTLKGCINFLDDLVMISFRLKTLPKNIRQRALEIELEYLNLYLPADLSIPFSGGKKVLNLEIEHSTTLSSAENCPFILTYECARRIKKTKKSFYNDIYLLRQLYALEKTGAENQAIKDKIVEQLMHENPGHAENSGSSATDTEDNAASQSGKLTGNRKRWAEKDTLPFLGKRKNWTDITREVLVKSEFKELRPEVKCVIIKTGNELGPEMIALELLREMKQIIDEEGIRIWLRPYQIYTVFHNAGFVEVISSASSIHEIKKMNDSLVGGKSFLRKFYYETYGTGVDKAINNFLESLVGYSLVTYFLALKDRHNGNILIDNEGHVVHVDFGFVLGLHPGFYCVETAPFKMSSEYIHLLGNRMDEFKKLFVEGFMAIRKHSKRLLQILEICMNNPKYKFIDVGAVECFKSRMKNELNTRELEEYVVGLIDWSLKSMTTGLYDSYQYFSNGYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV82</accession>
    <name>L7JV82_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec61 protein translocation complex, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1691"/>
    <dbReference type="HOGENOM" id="CLU_187038_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV82"/>
    <dbReference type="OMA" id="FIISPVH"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8590" checksum="B627D22C7F5F3440" modified="2013-03-06" version="1">MKKQPSRVKELMNSQLKPFIISPVHVLIISLLFIGTVFVLHLYARFSPGTTSLQMVVAFAVLILSVFASYQLNKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVF2</accession>
    <name>L7JVF2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysosomal &amp; prostatic acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVF2"/>
    <dbReference type="STRING" id="72359.L7JVF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2348"/>
    <dbReference type="HOGENOM" id="CLU_706151_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVF2"/>
    <dbReference type="OMA" id="SSWMEND"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979066" evidence="3">
        <location>
            <begin position="29"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="466" mass="53392" checksum="763D2B2654E32F74" modified="2013-03-06" version="1">MLIHFICVLSLTLYHMPSLKTYIPYCQAQYRHIPQKKGFKLKKVIVLHRHGDRMPLKTYGKEKGVCVRCDVRRRASRMNVDWAKDRNEPWYDDRTDTYSMQKCRISKCTDGTLTVKGYNQMRRLGRFIKDEYIPRLGHVRLTDINFRATAVKRTHSSLSGVVSGMFEEDRMNVREEEVNAFSSWMENDGEDIGPDDDSPLNADGIQEREDTAYYDNGEYTSKTSKLIDDKVSEGPESTHKTEPRVKKLKKIKRENFGKTFTLKIPPISKDTLVGYKTCPKLTHILTLTTKKAFSNVKNQTDLQNITDNYLCSMCADIQLDCEKLSCNISEVYDVVTANFKTWTYQSILLLNHLEVLEFLFGKFAIDLGLLLEDNSKLSVLSLHDNSLSYVLAGLGTRVIERPPLASAIFIEVWENKGDKYVRVLFNQFVCLTNIDSSTNIPFDKLVRYLNAVKATDASLSEACTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVF9</accession>
    <name>L7JVF9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993954">
        <property type="protein sequence ID" value="ELQ75473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVF9"/>
    <dbReference type="FunCoup" id="L7JVF9">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1577"/>
    <dbReference type="HOGENOM" id="CLU_141199_1_0_1"/>
    <dbReference type="InParanoid" id="L7JVF9"/>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="OrthoDB" id="2185952at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="87" mass="9942" checksum="1A95C06D2DBF3DF7" modified="2013-03-06" version="1">MSKRIKKVGITGKFGVRYGSSLRKRAKICMDQKKKKYECPFCGKSNVRWQAIGLWKCKSCEKVMSGGGYTFETPLHCTIKQTLSRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVG1</accession>
    <name>L7JVG1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2016"/>
    <dbReference type="HOGENOM" id="CLU_145610_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVG1"/>
    <dbReference type="OMA" id="IGMLECA"/>
    <dbReference type="OrthoDB" id="10422255at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="128" mass="15009" checksum="08B89D25B889F017" modified="2013-03-06" version="1" fragment="single">VNMSSDEESINDIFDENSANNELEILKRESSLNLDQIDEIIQNYYKIKVDGYNKALEDMRKYPFIKLFIGMLECADNSEILYYLSSVDVDDDFMTKVTFICQKKIFDNEKILKILKSKSSEQHLICEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVH6</accession>
    <name>L7JVH6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1527"/>
    <dbReference type="HOGENOM" id="CLU_2514229_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVH6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="9303" checksum="F3EF4AA8A1F72167" modified="2013-03-06" version="1">MYTNISLLFFTLTAYGYELFGGLVVNARRKGSAKLKVASLVCIVVDNVTLLVMPGTLKGNTKVILFTCVAAMRGEYPVINVMNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVI8</accession>
    <name>L7JVI8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Rab-GAP/TBC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1638"/>
    <dbReference type="HOGENOM" id="CLU_084270_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVI8"/>
    <dbReference type="OMA" id="RTYFDYG"/>
    <dbReference type="OrthoDB" id="2193149at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="46"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="315" mass="37448" checksum="386EC331576DDAF6" modified="2013-03-06" version="1" fragment="single">VRIPHYKNLFVVYPFMSKNRPVEDYLALRSVINKYETRKPPGAAVKSQDDLNVIKMDVERTYFDYGDKDVTLLRKELFNLLIRIPFEYVQGMNDVAAVLVYFYAESESMDEVALNSIDTKDCADDDSDSDRGVIYRCKNGQFVPSSTPNEYDNTVDQKIFEDVTEYEDITNLMNNATRRRMLTAVYHILKDKYLCLVQNEFKVYLAMNKVMLNMLNKEQKSVSVNESIRFMNYTLTWFSRILKRRDDVYFIFKIIIEEELCILFVIMFKFYSEKSIGNRKMFQLNLRNLKCEFKEEENEIRKENLSFGKIIWDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVM1</accession>
    <name>L7JVM1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993993">
        <property type="protein sequence ID" value="ELQ75091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1974"/>
    <dbReference type="HOGENOM" id="CLU_3108108_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVM1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="51" mass="6417" checksum="207FD1D84C2833FA" modified="2013-03-06" version="1">MVYKYHCKYTFSSMYAKRLKKNKEDFLKYLYSFHRTAHIRFNKEDVINLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVP2</accession>
    <name>L7JVP2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2284"/>
    <dbReference type="HOGENOM" id="CLU_2948398_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVP2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="7075" checksum="C541DBE6F26DEB69" modified="2013-03-06" version="1" fragment="single">VFILNNSYVKKIVKFIYGSPHLEIIWIYVHVPSVTRIMVQCASDDILFNKKRPKTRVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVR4</accession>
    <name>L7JVR4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVR4"/>
    <dbReference type="STRING" id="72359.L7JVR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1562"/>
    <dbReference type="HOGENOM" id="CLU_323423_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVR4"/>
    <dbReference type="OMA" id="QINICIC"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="468"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="722"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="894" mass="100560" checksum="39B1996192DAABB9" modified="2013-03-06" version="1">MTDAFSDKKKNNDKNDVYVFKNTRKEETNGGVVNGCRVKKEYGGRDRCSRDDCFSSRDDNDSTARDDRCNGALNTTYRSTGTYRTASDHSNAYGSSTTARQSLTGQKKYSNEINAHKQTINKRETAPEMSRDGTAGTAERKTFFWRTERVARDGRGWYGTNALSGTRNARSTDGRGEYNDYKQGKSYTAQQGSERRMERGGWRVSNEGLNGKCSFSGKGGVDHNYGPYMKGGAYSRSGTWRGENRRVDEGRRVYESKGDGRRVDEGRRVEESRSDGRRIDESKGDDQRVDEGRRVEESGRVEESRSDGKGDDQRVDDDQRSNNTRWSNDDQRSSNTTRSNNNDRINNDRIKNNKIDDREGNDSKSYDYSRTAPLNKQNGATTGNAYVPKTGAFRGGRYGHDESDGYNRKGTHSYRTYTSTAAKGRSKQFVFPSTYKTTEQYVITSSHPFMRINGNGKIKYNTLQRYAMHYIEEGKHMILRAPTGTGKTLTYLLPIVSNIEKVFVSQRVIKMLVIVPTRELAAQIVSEVNKISTLSVRMVIGGGEYGMDGNVVVATPGRLIDTLNRYYRYNHGDAHGVHPLLAQLSAIVLDEGDTMFDLGFKQDIAAVLSQAHRDVQLVIASATYNRGIMECIREWRCDWVYLCFEMDGMVEQRVLMVGDKFKELVRVIREYCARDDCRDRGRIEEGVDRRDRIRLDGRNTGEVLKKEQAGNNDGTTTDGKGSTEQGACRKEQANKILVFVKRKRTVDALANSLPFVLTSLHGNMPQHQRAANLAQFHAGVNILVATSIAARGLHIQNVNLVINYDLPDNIDEYVHRIGRTGRGKKGTSISFWNGDLLGTHLATYLESCGCEVPGFLKGERTVENVDLQSRFEMMKFADEKSGDSEEGWDDFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVU3</accession>
    <name>L7JVU3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994013">
        <property type="protein sequence ID" value="ELQ74867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2196"/>
    <dbReference type="HOGENOM" id="CLU_814315_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVU3"/>
    <dbReference type="OMA" id="EFNIEYC"/>
    <dbReference type="OrthoDB" id="2190427at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="342" mass="41114" checksum="97D7CD2E19FCC684" modified="2013-03-06" version="1">MMEKYLINYLNITQDHVDPTDYDNFAEECIEYVKNNRKYISLVLESLNIFKNDELLSMSYKILRNTNGDKSIDICDNILRKHIKNTNLRDSVILYLSTTDKNICKKYILKTFYDKYEFNIEYCLIFNNSCYQEEFIKFLELQQPKFVERKLYAMIYTGRFYNIWEYIEDFGAEDKFRSSLVCNLFSLLVEKVQQAIAQFKGESCKQQIQTFFKNEFYVGRTFCYRCDKFILCIDENTFFIEMVGKERLNVRSANNFVVNFLKFMREEKEVIEWIKNGDEKKIKETLSRYILKAENFELQHYTDLETDDTNSNNYVEENEIDINFDYLFESKCLKSHADCAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVX3</accession>
    <name>L7JVX3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="7"/>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVX3"/>
    <dbReference type="FunCoup" id="L7JVX3">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1442"/>
    <dbReference type="HOGENOM" id="CLU_1086541_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVX3"/>
    <dbReference type="OMA" id="IMNSIPH"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="157"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="178"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="263" mass="29286" checksum="F2FAB2318409B17F" modified="2013-03-06" version="1">MEPKNHEICKLSKNYKIPKKCTKTDYKTSSGVLLLIGGCDLYVGAPCYVSKAAYATGIDLCYILCDGCALIPLKTLLPECIILSFDQFELEKHTFILERVTCCVLGSGLGRLNERVEAVISELIGRIRVPLIVDGDGLYLWDKMNFTYFDTVIFTPNRNESEKYLKNVDLKKDIVLKKGPVDIITYVDSKITINSNSGLRRCGGIGDVLCGVLASLVNVYEDKMLACKYASLIVRKASYAVYKKMGRSTMPTNIISEICAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW48</accession>
    <name>L7JW48_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Golgi reassembly stacking protein GRASP65</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW48"/>
    <dbReference type="STRING" id="72359.L7JW48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1345"/>
    <dbReference type="HOGENOM" id="CLU_410597_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW48"/>
    <dbReference type="OMA" id="PFIHTIT"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="669" mass="79019" checksum="DB7D45DE9ABED804" modified="2013-03-06" version="1">MGQTITDESVTLQITKITQNSRAHRLNLLPFIHTITLVNEKTVGSSEDVKKEFIKWKQHNIKLQVLDLCTQKIKDLELEKCVEGESLGINVKVHKGEPYCPTLCLVEIDEDSPAYRAGLRVFEDYVIGIEGVYIPNEDAFRRRLYGFIGRECVLFVFNRETNTIRRVTVVLNDDPENLMGAELGTGLLYKIFDESDEAIRLVFDDEEYCRILEKKKREEEETSKEKNIKTRNESVVDEKRGDYNEKEGESVAVISEKEVNEEKTDERVNDVTAEKKKEEVFEKIEKIKINDEEIEKANGVKIEEKNDEQKRIEEENERKANALRKLEEVRKAKEIKKNEEMAMKQREEEKRREEERLEKENERRREEKEERQREEERKRKEEQRRREEERKRKEEEKRKEEQKLQEERKTKEEDEKRRLEEQKKAKADEIKKLEEQKRIEELKRAERIKAEEGKRLEEQQRKEKLEQEKKIKTDELRKLKKKKKREELKNAERINAEEMRRLDDLKTKDELEKQTKTKTEELRKLGEQENLEKIKDGEVERRAEDAVGGGANDGSDSIKEEMVEPKKCDDIKGAFDPESDFEEIDLEETQEYTIIKSSSSPHIVNHDGSIKERSISDPNNFDNVSDTVYDDGESLVYKDGSGFDLELKERLGDKGIEESNGSDAKLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW86</accession>
    <name>L7JW86_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1448"/>
    <dbReference type="HOGENOM" id="CLU_442276_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW86"/>
    <dbReference type="OMA" id="FFYMRSE"/>
    <dbReference type="OrthoDB" id="2196302at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="612" mass="73119" checksum="0FC48ED74734FFC8" modified="2013-03-06" version="1">MKELTISTFRLKNFNLENLLTEIIRGKNTKEAISQLTELKDAIFHKKQQILKLVKQKGHPNFSEILNAFFGEHNHLHLSALGDIGDAISRYNNLREMKLCKRIIVHIDEMRNGFYENISAIIKTDDINDLYMLAHVFLFFNDAKSSEEDNNLDIARLDRILALKNEFIETARNNFERAQKEKNVFIMKGTYKALKVLKKESVLVNIFMQNLKIFNLVCEEEDGDELVFNLDFFDYSTWFFKFIDTVQETYENELINLEDVLDAQVIQKINEKLFETVISNAVGKLLRMKKDVEFLWYLSNSYTRVQSLYRFVSTFYAFNYNIRDIFSQYFVGISKRENECCDFVLSTMTGEKEAQKKYVLLNEQLHAEQDERTIILKMLCIYNFFYMRSELLKYDSDDVYFVKKHFLKSVETLIMKNLRYNLKNFRKLNEYFFILKKVQLESKFIKDKMREIFGNYLDNSKKDLKIIIKSLTIDDLCKKENRMVDKLIYFLKTENKKIQKYVKGPNALALFYNIVDYAHDHLYKQILTLTYDRERAYILYNDVETVRKFLKKMKVFETPFDTLKNIMELLVLEKDVLAIYVHGFKELERSEIKRILKCRKDYVHVKECLNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWF4</accession>
    <name>L7JWF4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1398</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993936">
        <property type="protein sequence ID" value="ELQ75645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWF4"/>
    <dbReference type="FunCoup" id="L7JWF4">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1398"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_4_1"/>
    <dbReference type="InParanoid" id="L7JWF4"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="187"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="407" mass="45856" checksum="2562C7EB5C238907" modified="2013-03-06" version="1">MSHSEIIQDLLKIRPNLFNEDLSELDVQAKLIRGETDMIKSVISNIEHQIRVKKEGITENLKKIKLNRQLPYLVGNVVEILDDEENDKSAVVSTSTRVTSFLPMIGLVEAQDLRPGDMVSLHKETNVIFEKLPPDYDTRVKAMELDEKPTETFEDIGGLERQIMELTEALVLPITHPERFRKLNIRPPKGVLMHGPPGTGKTLMARACAAKSETTFLKLAGPQLVQMYIGDGAKLVRDAFKLALEKKPTIIFIDEIDAIGTKRTKSDRIGDREVQRTMLELLNQLDGFSSSDDVKIIAATNRVDILDPALLRSGRFDRKIEFPLPNTDGRKRILQIHARKMRVSNNVNFDELARSTEGFNGAQCKAVCVEAGMVALRKDHKEITQNDMIDGIQEVLAKKKSTLMYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWG4</accession>
    <name>L7JWG4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1282"/>
    <dbReference type="HOGENOM" id="CLU_3368784_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWG4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="4059" checksum="0A40347F063593D8" modified="2013-03-06" version="1">MMNIVSIGKIKIGDCKAYYEKIFIEALRERGLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWK2</accession>
    <name>L7JWK2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar assembly/sorting protein VPS9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993913">
        <property type="protein sequence ID" value="ELQ75858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1186"/>
    <dbReference type="HOGENOM" id="CLU_477499_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWK2"/>
    <dbReference type="OMA" id="RTITHKH"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="393"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="571" mass="65432" checksum="6A65FD05CBB9443B" modified="2013-03-06" version="1">MLLLHAKHRITYQLRVLNVTITYQASYYVSITHNQSTILKLNQTIKYNTTIHKNKQTMTKSKHSSENHSELKIVIDQKSTQNHPIPQPANTSTTSNFISTCSNTCMNELARAMCANSTLRTTVCEFMNGFGVLPGNTHRNTLIRFYDYLKITGDVCCDVGVFYVEKYLWGGCEEGNSSDGNGDDRDGSGKERSANDGNNNADDSKEKGSLVREEEMKSVKKNEERNRNNDRVMKEIKVEEKYKIKDSDRIKHASKKRGDKLGLGKDKQGVINEVYGSNNGKTRDKNRDKNNGKNSGKYSDRCNKNCDKNSEKNNNVNNYVNDGNNSDKTNQINRNNKINNNNKNNKTSKTSKNNINTKNVTNTTNQSKNTNTKQHSNNVSNAVPIRPVVRIRKDDNLLINNKIELYSFIKEHHLEIQPFTNNEIITYFRTITHKHSVTEKLNVIIKTIKDVYVTVGCEKGIERLLTVLIYVLIKSRVKDLCVIAAVVKEYRRCTYQQCSGAPLCTHLKGIHVYVQPCECYVRPILSDSEIEYYLTVFESALLFIKEIEFCKLRISREEYDENILKRIERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWP1</accession>
    <name>L7JWP1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1520"/>
    <dbReference type="HOGENOM" id="CLU_2203403_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWP1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="12286" checksum="8DF3357D7FBF6EA8" modified="2013-03-06" version="1" fragment="single">VNIDECLSIKSFNAFPKNVVHISYRKSKVDHNMKIPNHIESVNIKFSGWGPNETLTLSKNCKSLILDDSTGKVIFPSVARCQMESRMETDGSKFEFKINESEKQKSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWR4</accession>
    <name>L7JWR4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative WD40/YVTN repeat-like-containing domain, WD40 repeat-like-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993910">
        <property type="protein sequence ID" value="ELQ75869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1163"/>
    <dbReference type="HOGENOM" id="CLU_1109293_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWR4"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031544">
        <property type="entry name" value="WD40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17005">
        <property type="entry name" value="WD40_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="251" mass="28285" checksum="4ABB5F992CEBBC1E" modified="2013-03-06" version="1" fragment="single">VKERRCLHKDISFVTHHKNILLIGCTDGEIHLFYKNLQHHINLAGHKSEITALSILNNYVFSCSAQNFIVYKNNSVVHNHKTNELKGMRVIDDRIYLMYNHCIRVLKHDACFSTSYNEKEYDAYFGDNTAYYGSESFSHVYDISSNATECIAKINDDLVIGGEYLMVMVKGREHRTAVQHVNLLVVSNTIVVFATLDGQIGIGDYREEQFSMCDGGVGLVYDMVLCGNVVYVAGENGTNEILLEDCGAPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWU3</accession>
    <name>L7JWU3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1144"/>
    <dbReference type="HOGENOM" id="CLU_2814236_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWU3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="67" mass="7658" checksum="6626561A6EA33F8F" modified="2013-03-06" version="1">MADKNEKLKRVNEINSGLAKDRKTGYCKMIARKDEFAKTVLRWTIVGIAACVFLIMFKLCSYVLSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWV6</accession>
    <name>L7JWV6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993904">
        <property type="protein sequence ID" value="ELQ75914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1122"/>
    <dbReference type="HOGENOM" id="CLU_861030_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWV6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="323" mass="36273" checksum="B7090A1398E2A4A5" modified="2013-03-06" version="1">MTKRSLLNVSTFNNSNSNRTHDHGETGREKTVNSGLHGQTNDTVMLESDSGSRNDTASEHRKETKYVATTNNTAESVQYEEETTSSFEKPSSSLNYEATDWTVLCLKICNNQRYCSVQSKPHSQHGYSLSGLEIDCKNESPKKHDCSVDLFFEQSKNSENDGRTSREPLFYISCESYQHNNSNAFKCVKDPHIQDPKPENTLNMKINCVGTDNGELENCTLSHNPDKPGKLVVEDIFINGYENDPISIYKGNITVALPDSDGPVNTPSLTNVPSYTSSMNNGLMITAFVALALLIFSCCIVAYRCLRKKWRSEKQKPKNKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWY9</accession>
    <name>L7JWY9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993890">
        <property type="protein sequence ID" value="ELQ75993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWY9"/>
    <dbReference type="STRING" id="72359.L7JWY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1045"/>
    <dbReference type="HOGENOM" id="CLU_000384_23_4_1"/>
    <dbReference type="InParanoid" id="L7JWY9"/>
    <dbReference type="OrthoDB" id="2194934at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="97" mass="11547" checksum="F121556CBCBF16F4" modified="2013-03-06" version="1" fragment="single">MIYGISEKEMLAVKWGIDKFSQELKARMFYLITDHKALEVIRNKPEFDNNRLNRWCEAIQQYDFTIEYSKPVNLIKADALSIIHEKVKEPTEINKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX10</accession>
    <name>L7JX10_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1454"/>
    <dbReference type="HOGENOM" id="CLU_1090655_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX10"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="255" mass="30030" checksum="6603966F852219B7" modified="2013-03-06" version="1">MYDYRVKDFLRALDHNVHIEPPYIISFDDDNLHLYDMNTFTLLKRFSISNIEMVGMLSNYKERFLADREDQDGHSRVEKVRVTEKNNVKCDSRNGIVPFYFLVYKTNNLHIYRNNSIIKKLQLKNIKQMVSTNSHIYTLSKSHLFILDYDLKIQKRLDVPVDWSLINNKFIATKDGKLYDLEMRLVSSFEKEVSFANSKDCVGFVDGTFSIDKSNQIKRMKINVSGRVLYLDAENIITEHSFNGRRTPLHSKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX19</accession>
    <name>L7JX19_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major Facilitator Superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993916">
        <property type="protein sequence ID" value="ELQ75850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1192"/>
    <dbReference type="HOGENOM" id="CLU_054257_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX19"/>
    <dbReference type="OMA" id="MPVISCT"/>
    <dbReference type="OrthoDB" id="10378782at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23522:SF10">
        <property type="entry name" value="3-PHENYLPROPIONIC ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23522">
        <property type="entry name" value="BLL5896 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="9">
        <location>
            <begin position="53"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="301" mass="34090" checksum="E77C2127EBC5246E" modified="2013-03-06" version="1" fragment="single">VFFALVLNYMKRKRIQESKLVMINIFSILGNACVMFIMPVISCTGIIKNDRLLSLTVCIVAGTLAIILLLLKTPKFKKDVKENLTREGRIMHVILKPSVLLYYASVVAIGVYKCIISNFVTTFLQINGLQMNTIRMLWGTRCIAELFTYIIIPYFAFVPNNILFVISIFVSALSIAFYIFPELNTTMLVISEVLKGAGTASFVYTSILIFKSYATNDIQTQVQGIRNSAYNGFSCILFGILAAVLIDRDLKDPRTVNEDESDEMRNRMLNVFESSYFIIFFSLLIAIVPAILARFLKKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX31</accession>
    <name>L7JX31_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993890">
        <property type="protein sequence ID" value="ELQ75989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1041"/>
    <dbReference type="HOGENOM" id="CLU_2361224_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX31"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="96" mass="11061" checksum="56B1943716963589" modified="2013-03-06" version="1">MLAFTRNEKITPSYAILTIGMADLQRALNARIKTASYRNIPLYVVDECYLVVQHDNIYFCSCGRVVCWHVYGVMWGEWVGECDGDKYFGVVDERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX58</accession>
    <name>L7JX58_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1012"/>
    <dbReference type="HOGENOM" id="CLU_562836_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX58"/>
    <dbReference type="OMA" id="CEMTGND"/>
    <dbReference type="OrthoDB" id="2192347at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031522">
        <property type="entry name" value="Mad3_Bub1_I_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17014">
        <property type="entry name" value="Mad3_BUB1_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="575" mass="66128" checksum="64568211EF627713" modified="2013-03-06" version="1" fragment="single">VLSACIRHSLFSYSRHTTQMNSHGAVCLVNAVHCRNFTNLHISDPVGAMADFPVDDIPRTIKRYINEPLYRNEPSFLHLFHVFYKQDDDINVIFLMYLKSIGKYHYFVYACLARHFLRINEPGKALFVLQEGILNDCIGKDRLMNIKCMIDSHDIDHDAHDDVLPASVRVFGREWIQIAVNYAAVDVVCSALERKAKDYLEKLSWVEESVWNVDELSGEELLGDGRDRKRRKSIVEMVCVGIEEDWKNERSIVEDNSGNDGEDVKECEMTGNDGEKDVKGCEMTGNDGEKDVKGCEMTGNDEEKDVKECKMTVDGDTVHDELKNGEKSAFGSQNENKPTTDGSTNVITPIKLFGEEYFCSPEDQNVESVDNVAMEKRSLFKLSGAMYIVKEIENDHVVITSIENLNEEHTFTSREYVLKKVCKTVDLEMIRAIIPHELVYIRINGQLYTKYVKPFLYTLGESEQWLSSNICAYFVREMIKILRLVYMCGLCVELSLCDFNVEEEDEQLVLKLNNLNFGDRMRFDALELMVKRARIATSENPNDIEESAWRRIRQMNLADEFLEYKLRLLGGINYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX82</accession>
    <name>L7JX82_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA damage inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX82"/>
    <dbReference type="STRING" id="72359.L7JX82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1739"/>
    <dbReference type="HOGENOM" id="CLU_621408_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX82"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="441" mass="50770" checksum="9FBABB153099D3B7" modified="2013-03-06" version="1" fragment="single">MVNNLIDREEDFINKISGSQLIAGNIVYYDEENAFDTKKEERIEMTRTRARAIKEKIAQFTDNELRYAYKMVQIEKERLIRAWPALFDSDYMLNNVFIYIDIDAFYASVEMIVNPVSGPLAVGSMSMLAAVNYDARKYGIRSGMPGYQGRTLCPSLVIRKCNFELYNIFSERVMGMLAKFDENIEIYGLDECSLVMDEEKMRKGYMYFCEWDRGCECLLNDGLDDFSCNTRTTDSFDSHQNSTENGEKPIGLQEKDAKKMQIKPNETYNDGKKHIDLVSTAATKIEEDVIATKTENEMMNPQNEFFFDTCSQTTKCTREELFSLGNENKIFIKDYNVEDKSYGVKRSLLDRKSALPKINESPGSLLDISVATDATNHLTYENSSHFQICAEHKKKYKIFHSPLRTLNGLSMLFVLILKNTSGLPLVQEYQYAEVYPSYAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXC4</accession>
    <name>L7JXC4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1348"/>
    <dbReference type="HOGENOM" id="CLU_2910605_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXC4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7121" checksum="FEC76DF0015F7F9A" modified="2013-03-06" version="1" fragment="single">VTRAQYPHTEDGMALSLTAIPPMKDGQQVCFKGTNRLMRLRNDTPTYHTERWGRIGCDDEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXL3</accession>
    <name>L7JXL3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Cyclin-related 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0837"/>
    <dbReference type="HOGENOM" id="CLU_1267753_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXL3"/>
    <dbReference type="OMA" id="RITFCAL"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="217" mass="24875" checksum="B9DA1D81CACD0681" modified="2013-03-06" version="1">MRIHVHDTIKLYKWHRRALIPYLHTVFGSKETVIKVYRICVSGRITFCALLSAICVMKKVVKYNEMKIVELKGKSVDGKEGTDGAQYDSMRDKRTSNGCRMKVHELNGPLKKLSTSLKDDYLLFAASLIITTKVLFDYVYATTDWSKLTKLTVKQLNEVERYVLFLLDYKVVLENGDVEVAMRIFEKKGECKVVFGKKSGLRGVVEWMVNLFGCENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXT7</accession>
    <name>L7JXT7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXT7"/>
    <dbReference type="FunCoup" id="L7JXT7">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0785"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="InParanoid" id="L7JXT7"/>
    <dbReference type="OMA" id="QTYSIFP"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008275">
        <property type="term" value="C:gamma-tubulin small complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005822">
        <property type="term" value="C:inner plaque of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005824">
        <property type="term" value="C:outer plaque of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051417">
        <property type="term" value="P:microtubule nucleation by spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000767">
        <property type="term" value="P:positive regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="33"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="418" mass="47125" checksum="89AB9E4D9990CCBE" modified="2013-03-06" version="1">MREIITLQIGQCGNQIGSSFWQRLSSLHPKSQPSQFFYLADDNMPVPRAILLDLEPRVISQITSTGLFNHENIFVSNEGGGAGNNWASGYLCARSRKNEIFEMIHRESENSDMLESFFILHSIAGGTGSGMGSYLIEELRDEFPKKMLQSFSVFPNNEEVSDVVVQPYNSVLTLKRLNRCCDSVVVMDNAALGRISSESLRIKQPSYETINSLISTVICASTCTLRTPTYMYSDLRSIVSTLIPVNGLNFIVPSYTPFINKDCAQIIRKTTVNDVLRRLMMSKNKLAGIDTRAIISALTFFINTNEIGEVQRSIIRMQDKQLVGFVPWMPPSFHAVVCQEDNAAEQQVSGLSLTNSTGVSALLRKICEQYDKLKKRNAFTEIYRKYLDGLEEFDASREVVEQLIAEYERCELTSFCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXU5</accession>
    <name>L7JXU5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXU5"/>
    <dbReference type="STRING" id="72359.L7JXU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0795"/>
    <dbReference type="HOGENOM" id="CLU_027543_3_1_1"/>
    <dbReference type="InParanoid" id="L7JXU5"/>
    <dbReference type="OMA" id="GYAQEYL"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="134"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="308" mass="36633" checksum="9817784FEE44F768" modified="2013-03-06" version="1">MEWQRLETDQYVNLDKTLYSGQIFSFQKTGENEDTGMVEGFLTTFKQDGDHIYYKIFNYKESVDYQTIFSRFFTLDLNYKKITKEWNDKLLKCENEVYDENRLNNGLCTLRPFKETGLRLLRCDLKETIFSFICSANNNIKRITKMVLVLFSLGKYITTINDKNFYEFPDPDQLCDKELFLRESGFGYRASYIVKTAQQMKMLKYSQLYNLDYQHAFEMLNEYNGISYKVADCVCLLGLHFHSVVPIDTHIFKVASRIFSIKQTKLNKRTYVNIRRQFQEFFGQYSGLAQLFLFEESIRTRKKNSSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXY2</accession>
    <name>L7JXY2_TRAHO</name>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0699"/>
    <dbReference type="HOGENOM" id="CLU_1001841_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXY2"/>
    <dbReference type="OMA" id="YLPIFKE"/>
    <dbReference type="OrthoDB" id="2191914at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="281" mass="33149" checksum="6869F7FCEA208817" modified="2013-03-06" version="1">MDKMTYDITEEDIARFSTIEHEFSSVKEHFSNYKFALIERESKMLFLESIKDDVQVDYLPIFKESKKRLEETKEVGVALGEEIKALSMKNYELKRSISSIVVEYDALEELKKRFLESGNEFNKAEEINRLEREYNTASETAKGMVAELERLREEGEALEAERERSYVTHLRERVEELRRKRKRWSRVEYDRMLIDAYRWYDMMISVLEMFFGTLGEVVPRKNGFDLNVSVGGTEMVVMIRNGTFVGVGGIENEWASDIVRWCVRLESARLFVLLAKRQLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXY3</accession>
    <name>L7JXY3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1423"/>
    <dbReference type="HOGENOM" id="CLU_3282351_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXY3"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4657" checksum="32BB5E1044617614" modified="2013-03-06" version="1" fragment="single">VFLNKAYENENSNVNTNTNADNNNKAVLHTMRMLHVLLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY21</accession>
    <name>L7JY21_TRAHO</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ75956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1077"/>
    <dbReference type="HOGENOM" id="CLU_1300461_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY21"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="212" mass="24971" checksum="617E48BE4B0C8772" modified="2013-03-06" version="1">MAPQELDIDDYDIDRDELHIMDNREIVDICKNFLQTNSQEIEEVHVQSSHELMKRRFRYKLIKIPFTKEILVGIFALPVYNKESSTTVGTQEPFLLYSNNEMLGEKFFPHHSQDSVPTNESALILHQYKSQRNYDLPGRFDLLIVHKKKQHISYGFVDESGNIIIIPQENDILLVKIHIKTFIEKLIPSANHFACDYRYILDNTEFMRRNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY25</accession>
    <name>L7JY25_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1065"/>
    <dbReference type="HOGENOM" id="CLU_3302232_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY25"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="4549" checksum="4C469698B2A9E13F" modified="2013-03-06" version="1" fragment="single">VILLNSKIVVRGAAKYFKGRSGDGNKWKEMRCYVRCSSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY80</accession>
    <name>L7JY80_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY80"/>
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    <dbReference type="HOGENOM" id="CLU_3263268_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY80"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4389" checksum="69FBC4C7959EAB63" modified="2013-03-06" version="1" fragment="single">VQLVDGCTASVTSQIISSGLLTTHASDAVNNKNARKTDLVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY93</accession>
    <name>L7JY93_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0591"/>
    <dbReference type="HOGENOM" id="CLU_2623748_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY93"/>
    <dbReference type="OMA" id="LYIYFNA"/>
    <dbReference type="OrthoDB" id="2187855at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="78" mass="9219" checksum="628D7E71752FC091" modified="2013-03-06" version="1">MLSSLQQEINNLLYIYFNAIGLLQSKEEVDLSFLLDELQSCKERIEKLLDLEEAEDVEIDIREDLEDAQAFFEFFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYF0</accession>
    <name>L7JYF0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative E3 ubiquitin ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYF0"/>
    <dbReference type="STRING" id="72359.L7JYF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0647"/>
    <dbReference type="HOGENOM" id="CLU_1723612_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYF0"/>
    <dbReference type="OMA" id="HEFHCKC"/>
    <dbReference type="OrthoDB" id="2193062at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000388">
        <property type="entry name" value="Putative RING zinc finger domain superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="152" mass="17888" checksum="5931F923DCD29461" modified="2013-03-06" version="1">MSAQKNDKRKVLDRINLRRRRPNTTPPTSTVETFYITLDNISADFDVSNILFNLFPLIERFRDTSTLTNIILYFYPVKKRNVLSRKSLNALKKRVYTDGDEQCTICLQNYAKNDMIRELTCKHEFHCKCVDRWLLRSSDCCPVCRKRVGEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYF4</accession>
    <name>L7JYF4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYF4"/>
    <dbReference type="STRING" id="72359.L7JYF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0526"/>
    <dbReference type="HOGENOM" id="CLU_026126_10_2_1"/>
    <dbReference type="InParanoid" id="L7JYF4"/>
    <dbReference type="OMA" id="MEHSEIK"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02066">
        <property type="entry name" value="GRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46679">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46679:SF1">
        <property type="entry name" value="GLUTAREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="93" mass="11149" checksum="C62341B8901D7CF8" modified="2013-03-06" version="1">MAEILKTDIFPRINELKEKKRNILIGFKECPYCVRAEEILNTKNIEFDYIYRAREEELEEEIKKCYGHETYPMIFINGEFVGGCAELKEKYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYJ1</accession>
    <name>L7JYJ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993843">
        <property type="protein sequence ID" value="ELQ76533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0483"/>
    <dbReference type="HOGENOM" id="CLU_2518846_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYJ1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="10190" checksum="E4DFA20261A0B871" modified="2013-03-06" version="1" fragment="single">VIYYNEEEERVLIESNKMVGNSNMSCMFVGPYNLAMFYKRMGNGKNFVRFMKEARKSAMMRGNYDGIELCQDELRKYRKEKNKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYJ2</accession>
    <name>L7JYJ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYJ2"/>
    <dbReference type="STRING" id="72359.L7JYJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1268"/>
    <dbReference type="HOGENOM" id="CLU_1020094_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYJ2"/>
    <dbReference type="OMA" id="DHTHPNT"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979151" evidence="2">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="273" mass="27415" checksum="D9DE7ABA606E9834" modified="2013-03-06" version="1">MNNLIMLFTTLLGIVLTEKAKTSGGMFGGSDEANPIVGEKGEEKQEGSGLFGKSGGSDDEEKKDGSGLTSKSGGSDDDKSEEGGEEDDEKKDGSGLTGKSGGCNSGGSGEEDDEKKDGSGLTDKSDGSGEESEEGSEEDNGEKQNGSGMFGKSSGSGEEDDEKKGGSGLTGKSGGSGEDDDEKKDGSGLTGKSGGSGEEDDEKKDGSGLTDKSDGSGEESEEGSEEDDGEKQNGSGMFGKSSGSGEEDEEERGGSGLFGDPEEGSDAGSEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYP5</accession>
    <name>L7JYP5_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase, LTR Retrotransposon</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYP5"/>
    <dbReference type="STRING" id="72359.L7JYP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0586"/>
    <dbReference type="HOGENOM" id="CLU_000384_42_10_1"/>
    <dbReference type="InParanoid" id="L7JYP5"/>
    <dbReference type="OrthoDB" id="2193995at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="145" mass="17304" checksum="0A75D9E960F2F5DF" modified="2013-03-06" version="1">MIKKGIGIRWSLKDRVSEYLKRLERKRIIIKSKSDWRNPVKAIENPDDGMRIVSNLMLLNDLTEKDLYKIPDMKRIVKATTGSKNLTVLDLKEGYYQIEIEETDKHKTAFEFGNNVYEWYGMVMGFKNTPMIFQRVINRSRWINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYQ6</accession>
    <name>L7JYQ6_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993836">
        <property type="protein sequence ID" value="ELQ76569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="L7JYQ6"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4758" checksum="585B868F7E03E177" modified="2013-03-06" version="1">MSESLELCHFGAPRRTKAKIESDYGRMGLKKWKGISIYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYT2</accession>
    <name>L7JYT2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0507"/>
    <dbReference type="HOGENOM" id="CLU_2832978_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYT2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7083" checksum="B10ED72445F2235D" modified="2013-03-06" version="1">MGECFIPVTALRGLVVMADEEEAVTALRGLVVMADEEEAVTALRGLVVMIDEEEAVTALRRIGCYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYX2</accession>
    <name>L7JYX2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0353"/>
    <dbReference type="HOGENOM" id="CLU_2943464_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYX2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="6967" checksum="9F795469820FFFAA" modified="2013-03-06" version="1">MLRCQELYIYENPREEEFLGVLLGGGYHESYDLRVKVTVAVAAYLSVVIKVRAKALREVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ19</accession>
    <name>L7JZ19_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993833">
        <property type="protein sequence ID" value="ELQ76575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0438"/>
    <dbReference type="HOGENOM" id="CLU_1778763_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ19"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="17004" checksum="57D662B69E77BF08" modified="2013-03-06" version="1">MYLYEMDRYELVKDSSSELEKELEIENPKVYDKFSRALERSKEDADYDALFNAIKELDMGDISSIISGLDNNSLYVVLQALKNNIDYNVVLAVKVFFSIVEHHRYFVAENQSAYVVYKEIRGRVELLRQLIKENEYKIGINGVMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ21</accession>
    <name>L7JZ21_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0409"/>
    <dbReference type="HOGENOM" id="CLU_2308023_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ21"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="100" mass="11737" checksum="A5776A75DE047802" modified="2013-03-06" version="1">MLDNSGIYHRLEIINNQKTSCLYQLNSQNIWSYGASKHLSSSYIMKHSNLIRRCRVIRIYVDMLVMDCLSISSLLIITANSLLVLNLQEIDYLERKDIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ46</accession>
    <name>L7JZ46_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major Facilitator Superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ46"/>
    <dbReference type="FunCoup" id="L7JZ46">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0315"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_14_1"/>
    <dbReference type="InParanoid" id="L7JZ46"/>
    <dbReference type="OMA" id="MDTIHTS"/>
    <dbReference type="OrthoDB" id="2196240at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="33"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="415" mass="46884" checksum="46A91BCF7BC6AC6A" modified="2013-03-06" version="1">MPKYYTRRRDPVEEQESFEHRYNPLTTKMLVYSTVMSCLSSFFFGFHTTSMEILKPLFSGETATAPFEMTDKMWSSLSSVIFLGAIIGNIFTVFLNINLKLCMFVNIFIFFIGHVFVMDTSNYYIMACGRLIIGIACGTSCATVPSYLGYLAPRHMRGTVGSAHQLFIVIGVLTGQLVSYFIRDNQIINIFYRGFIVLYIIALVLLTAIKNVRRVTTGRSKSVWDLLKCREARKSLKLDMAFHIGQQATGINAILLFSNEILKKGMKDPQLGTISLGACSIVSTIVSMCIVDKFGRKPMILISTFLILIALLMLTTGRLVLTSLYIHIIGYAIGIGPITWFIINEIFRDEYKKAASALSMTVNWISAFTATFSFSFMIIYMGNLCFLVYFVLMIVFLFIVLLSFAETKGRRSEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZE9</accession>
    <name>L7JZE9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">26S proteasome regulatory complex, subunit RPN7/PSMD6</fullName>
            <ecNumber evidence="2">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="2"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZE9"/>
    <dbReference type="FunCoup" id="L7JZE9">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0389"/>
    <dbReference type="HOGENOM" id="CLU_031814_1_1_1"/>
    <dbReference type="InParanoid" id="L7JZE9"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="169"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="360" mass="42095" checksum="2C2A342B4E11C219" modified="2013-03-06" version="1">MESEFKEPTLVILEKIKKSKEGDHTELKNYLIENEMGHMYHTLCNKHVLPDEPEVYLPILKKNEEMLQKISEQQTEDDGKSIKKERLEYLAKIGNLSSFVEESRDAVLTTSTKMDIVLCQIRLGMIFKDYSLIHDKINAGLKLSEKDCDWDRKNKFKVYYAFYNLLKSDYELAADLFASSLATFQCNELFSYEMAVNYTIFCSLLSFSREQLHERVLKSTDVLEVKHHVNLAYDLAQAIYNCYYDKIFPCLVAFSSYYMDDIFIGDKIHYFINETKIRSYNQLLESYSSIGLESMALTFGVSEEYLEADLGKFLVNERMKCVIDKIDKMVLVKEVDETLYDMVGDKCEKIVNYIEREVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZH2</accession>
    <name>L7JZH2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0560"/>
    <dbReference type="HOGENOM" id="CLU_171290_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZH2"/>
    <dbReference type="OMA" id="TCRIFTE"/>
    <dbReference type="OrthoDB" id="2192040at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="113" mass="13270" checksum="7780CFF09992DA05" modified="2013-03-06" version="1">MRVNNATVAPAKMSSAKRSKKIEHDLENDYDNNEVAQLKIDLLTAYLKSLSTYNYYDRKNKQANLMFLKISTLLEKFLQFENKKRYNDKTRGIFVESKVVDKKETALKMNKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZU7</accession>
    <name>L7JZU7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993800">
        <property type="protein sequence ID" value="ELQ76964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0040"/>
    <dbReference type="HOGENOM" id="CLU_218125_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZU7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5220" checksum="D316B846D32C01DD" modified="2013-03-06" version="1" fragment="single">VLEEMLDRVFSEQYITSMHNFVLTLDSYMLKVVGEKIMELLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZV5</accession>
    <name>L7JZV5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0020"/>
    <dbReference type="HOGENOM" id="CLU_2039698_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZV5"/>
    <dbReference type="OrthoDB" id="2195369at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031523">
        <property type="entry name" value="Acetyltransf_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17013">
        <property type="entry name" value="Acetyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="13873" checksum="DE1B955B6CD26D98" modified="2013-03-06" version="1">MESTRKVCQRYNLTRPIFALHLNPKDQMMNISFSFYVNLGFVNVAYVNDGPYDLQFDVEKISTKWDEIQDRPASGRYLAMFCFDGLGTGVKGDFREVGENIRGKLLQFGEENKKTTEKAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7K002</accession>
    <name>L7K002_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K002"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0106"/>
    <dbReference type="HOGENOM" id="CLU_797402_0_0_1"/>
    <dbReference type="InParanoid" id="L7K002"/>
    <dbReference type="OMA" id="CIEVYDM"/>
    <dbReference type="OrthoDB" id="10383132at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="374" mass="43414" checksum="8BF940CCE702761C" modified="2013-03-06" version="1">MAAIFSSQIFSLPFDFSLFFTSLRMHQEDMFQVVSLISKTTNDALIFHLPSNTTRNHLKSILNDHFNTSDFYKFYSAKPFSELGDVYEDEGKLEIFYEKVNVFNVDDDVLRVKDGYLLCRNGFYRGFKKISNLQKREFCVDSDQAAFLSEPDCIEVYDMKEPEGLCHNLEDNSYSHHVASVVRPTSDKEFILRGKQQFDKDIVAFILKNNILIVTCTDGSVYVIRNISMTDNQKQLLVRHNTPITLVDHSNDVFHLFSKDGTYLQYRYDERDAQASLTTKHYDMPVTAFMTNPLFVIATTSKLFIEDDKIELSIRYIKDVKTYFNRIYVCGQHRLIVIEQLKIVNDIKYENEIIGVTIVDGKVYLVEGNCVHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7K034</accession>
    <name>L7K034_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K034"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0599"/>
    <dbReference type="HOGENOM" id="CLU_3108106_0_0_1"/>
    <dbReference type="InParanoid" id="L7K034"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="51" mass="5859" checksum="4472B158C1034BC8" modified="2013-03-06" version="1">MEGSVEKEFVALINSYKEIVKEYKDNVNEAVLNIDEFNNIITGQNHKDTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7K057</accession>
    <name>L7K057_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">THOM_0561</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K057"/>
    <dbReference type="STRING" id="72359.L7K057"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0561"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="L7K057"/>
    <dbReference type="OMA" id="GYIHEYL"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="123"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="305"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ELQ76452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="476" mass="54675" checksum="F3181AF789F6C42A" modified="2013-03-06" version="1">MWLCVRRGPLRMKDSFDAFYDEVERRLREEGRIVTEDKHNVQVDNTCNIQNMDHSKFFVRTYSLADVRASRIVNKIILESVCMQRVENFLLKSFADVRLSLCIYNKLREMNINQPTPIQMQMIPLVLGGYNVFGQSMTGTGKTLCFALPLIMMKLEANHSFNGAIILVPTRELCLQIKAFLEHFVSVKSAFGGTVHKTEKARCNVGMSGEIYVATPGKLLQLLEKNNFARECSHLILDEADKMTSPEFVRNIKTIVEKMKRPQFCVLAATCFDSYRLKSFIRIDVNVFIGNKNAANEYVTQIIKLVDDKFAFLKEIVGQNVLIFVNSKDRADELTLKLRNFFKTECRTGSNDTSPYSWKMSAKVESLHAGKEQIDRNKIIEQFNSGSIEILICTSLLSRGIDFKVDCVINYDCPHTIDDYIHRIGRTGRMRYGTPRHGVAYTLLEKTDKTNVLCLYKFWIDSNVRLDENILNLLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K071</accession>
    <name>L7K071_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K071"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0509"/>
    <dbReference type="HOGENOM" id="CLU_3353554_0_0_1"/>
    <dbReference type="InParanoid" id="L7K071"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="37" mass="4408" checksum="B2331F42A781DC55" modified="2013-03-06" version="1" fragment="single">VVYCCDRMNSRRWSVWGWAATFAWYWVGNLQQPSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K074</accession>
    <name>L7K074_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993818">
        <property type="protein sequence ID" value="ELQ76751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K074"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0260"/>
    <dbReference type="HOGENOM" id="CLU_2962539_0_0_1"/>
    <dbReference type="InParanoid" id="L7K074"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6972" checksum="BA57129FD7D1293C" modified="2013-03-06" version="1">MIAVLQALFNLKNYRAAMEEIQPEQNTIESILKSIYKEMVERRGKSMTIDGYRKKICNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7K094</accession>
    <name>L7K094_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993843">
        <property type="protein sequence ID" value="ELQ76532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K094"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0482"/>
    <dbReference type="HOGENOM" id="CLU_3020135_0_0_1"/>
    <dbReference type="InParanoid" id="L7K094"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6703" checksum="6603743B9F6F0B3E" modified="2013-03-06" version="1" fragment="single">VCSTDIEKYLEEIKNVQNEKMRVVGKQATHVQKNLKRFTRERDNANDRLFYNVTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0B0</accession>
    <name>L7K0B0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993836">
        <property type="protein sequence ID" value="ELQ76567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0B0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0446"/>
    <dbReference type="HOGENOM" id="CLU_2446834_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0B0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="90" mass="10460" checksum="81CCE88FE4191F39" modified="2013-03-06" version="1" fragment="single">VPFFKKLYQKVMGLNIIDLKFETNVYIDIFKYIFINLDDNKYFLGNVCGCIQDYSPEFLDVFKKMLTTNHNQIRSTRAINLPAAVTSNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0B9</accession>
    <name>L7K0B9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0B9"/>
    <dbReference type="FunCoup" id="L7K0B9">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0B9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0302"/>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="InParanoid" id="L7K0B9"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="12241" checksum="4FF4577252E9E215" modified="2013-03-06" version="1">MAKKNTREVAFEDKLPLAIQTGDVLFGFKECIKSLMNQRCKMVVVSANLPPLKRRMLEYYAYLNNNVPLYFFNGTNNDLARSCDKFYRIGVLSIIDDGEADLIPAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0E7</accession>
    <name>L7K0E7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993800">
        <property type="protein sequence ID" value="ELQ76961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0E7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0037"/>
    <dbReference type="HOGENOM" id="CLU_628795_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0E7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="382" mass="43972" checksum="0FBAEFA623DDF020" modified="2013-03-06" version="1">MSLNHADAIALMICKLESGFAALKSQMPKSDRQKKVFSDLEAKLSRGVRNDRRLRLDDFVNTFSLLFPFPDAAVVEEFEVHRDLMKECVKVIDSSKCVIDMRMLSFNLEKMFRLCRVITSVSRYACGAVSMCMRPDYDDYSLILPDRNPGTFEPDRTVAEGGPLSKSWSKQPACFLEWMKWLNGLRRVMVSYLAVHNRCKLFSRLALEMVAIIEPAMKDIESNYNDYLDREERRTGWSAEPFASAPGEHEPLFKYSVRSGGIYENAFTGLSDVLGSYMSDEPGVLPFMRCLERNGVFPFELMERRKQFWDWVMSRKVERPVSTDMGELIDAVNASESAEFNAEVRDVVIECFDPLVNEWIGPFVFFLIAVIVSILIWRFKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0H4</accession>
    <name>L7K0H4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993821">
        <property type="protein sequence ID" value="ELQ76737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0H4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0263"/>
    <dbReference type="HOGENOM" id="CLU_1687966_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0H4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="156" mass="18718" checksum="3F0CAAD83A2C502D" modified="2013-03-06" version="1">MNDRKNLRITDYFNNLKEKLKALRETYSKRFRNEPKVQKQENTSFIKQEFDKIPYDDGAECMPQLNDMLDELSRNVNNFESITLMVLEQLLKNYLVCTDKPSSEVLKKINIKEIREFYAECKKYTWDNTFFNDKDVCSKLVDNLLIKLFGMLFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0I1</accession>
    <name>L7K0I1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0I1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0211"/>
    <dbReference type="HOGENOM" id="CLU_2251923_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0I1"/>
    <dbReference type="OMA" id="TGSIMEF"/>
    <dbReference type="OrthoDB" id="10423034at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="104" mass="11122" checksum="9B73013A9A358A9D" modified="2013-03-06" version="1">MTISTFLSFTTGILSSTIPQKPSKPLIIGALGTFSLFYTGSIMEFDNLVTMRPVKKSSVGYWMLCGGVMCAGLMGGGLVRAAGGNVLGRIKNRDKKLIRESLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR33</accession>
    <name>L7JR33_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3177"/>
    <dbReference type="HOGENOM" id="CLU_750454_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR33"/>
    <dbReference type="OMA" id="PVDYHPG"/>
    <dbReference type="OrthoDB" id="6625923at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="369" mass="40657" checksum="CF17BB3287824FB2" modified="2013-03-06" version="1">MLLYLVPFIHTFMDDCNDLANPAPPVDYHPGLNTMKEVENILKNDKDITASPVKVVKEKVAETEAIDPTTGEVVSVLENVGDKTGDFLKNVGSKLKDAKESLEENVSSTIKSVIDDAAKKVSEVKDDYVKKTEELGEKAKDIIDREVLTKMNEGEITRNLEEKETEALGGIKGLIDRADELLNGKLKENVNVVEKTSTAADGEVTTTETVTHPGGKTETVTHSDGTTTDTVKVKHPEERTVVTVNDDTGTVHTDKVIESPDKTSADKTPSDKPKETIEKKKETLPDGTKTTTEVHKKEEPPKETTTAVNGVHTDTLLDKLQKLRDKFKKHADLDVQMNSVGDDVYYPKIETLIYELAGLERDMEKMKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR74</accession>
    <name>L7JR74_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ73973.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3113"/>
    <dbReference type="HOGENOM" id="CLU_702136_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR74"/>
    <dbReference type="OMA" id="YETYYAV"/>
    <dbReference type="OrthoDB" id="2188448at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="442" mass="52304" checksum="647803A0446DBAAB" modified="2013-03-06" version="1">MYELFVRLSERNLEDVADEVLTSEEIKKEKYINSFVTIVGILPWNVLLFARLIKQMKTDDSVVKILAQVLEKQINERVEEKNIAVFLSFLRFLYVLEYLNVFEGDAISTIERLDEKVRRVIFDCKGLDRNKLLVKKEDESIRMNLKIKLEDPFAVEVCKYVENFSQTAVKVGMDGNDSLGDVFIAHHLVKEIDFDKQECCLQASCYFDENNYRELIIGILSAREIIPENSIFFRFIFVSLGKNKGFLSEFYKFVSNVEKNKFLYSVLALIYETYYAVPPKKQFYASYYYQPQLNEAEIDTFKSFIDENLAVEMLKYSNLQLLKNFLPENYFHLMPKEKSFENVELKRIVESNNIQKVDGMDKNDFFEQFCKMSYPSVSHFLVYLEIFAQYFNLSQEEQRAFLNIFYRINENKFSYIEHVGKKLLLFKVVDQSIADEYPKIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR93</accession>
    <name>L7JR93_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3086"/>
    <dbReference type="HOGENOM" id="CLU_2980758_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR93"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="6756" checksum="0F7223A004900ED1" modified="2013-03-06" version="1">MTCSDWTQTNIIGKRFITDYWIELLRTVLQVNFLVGEVRMDGTFALQRECFCPLSAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRI6</accession>
    <name>L7JRI6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2978"/>
    <dbReference type="HOGENOM" id="CLU_3279809_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRI6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="5039" checksum="7B9E142BBFE6543B" modified="2013-03-06" version="1">MNDRINDAKIVECHFDDTRKYFEESVDYQCYYIESHQLVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRI9</accession>
    <name>L7JRI9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2984"/>
    <dbReference type="HOGENOM" id="CLU_872088_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRI9"/>
    <dbReference type="OMA" id="MACVLLM"/>
    <dbReference type="OrthoDB" id="10309659at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36539" checksum="13C076010EF134DF" modified="2013-03-06" version="1">MGTLMLKITMSSPRGEILFETEMTANETVEDIKNYIVEKMVDNEAAIEIYRLNGLRRKHSVSEIKNRLVILYNGKKISDRIPISILNTTGTVFLQFDVRKGEEGSNYIIEHNKIENSIDEKECQKGAGSSFQYLSESSVTEQQCPAQTSAEDRKIKDSDVDSNVNDNITFEDTPLSNSSLNNEEDDIEMRQIERNVSVRNLLTGKLMAVDPRKVVKRGGRMYYLSPQPEVASEDTILKRFEWILLFVTPETIIKASMIIALFYSGNSPMACVLLMIFVLTFLSNQSLFNLSFTNTSFYEKVGKMAYSFVASMFLLSFESSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRN7</accession>
    <name>L7JRN7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994070">
        <property type="protein sequence ID" value="ELQ74138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2944"/>
    <dbReference type="HOGENOM" id="CLU_3371052_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRN7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="4360" checksum="0AB7F6E051202BA7" modified="2013-03-06" version="1" fragment="single">VWRKHFQELSRDRNNYSKNKTIWASIGDEKRNIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRR9</accession>
    <name>L7JRR9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3088"/>
    <dbReference type="HOGENOM" id="CLU_2074786_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRR9"/>
    <dbReference type="OMA" id="WELSTHN"/>
    <dbReference type="OrthoDB" id="10304321at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="14106" checksum="6B8B7D516E675635" modified="2013-03-06" version="1">MNRVDCLRRKKFGKIYQIDRRYNVAKSMFKIQTYGIKKADHVVCPNSECLEQELQKFLVHQIHKSVLIDSIETLAYDKKVIILFKYMNVEGIDVYLRTTGMRNFWYAEKKHQQDDEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRS5</accession>
    <name>L7JRS5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994071">
        <property type="protein sequence ID" value="ELQ74134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2948"/>
    <dbReference type="HOGENOM" id="CLU_115067_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRS5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978967" evidence="1">
        <location>
            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="188" mass="20742" checksum="359CA01739431478" modified="2013-03-06" version="1" fragment="single">IMLIGMMVLYTVLCRASTRKLITHCSHDNDVFPEKGIFVDDGIEFGFRQFSGDDDQEKVKARTTEFGRTTDANEVIEGNVESSIHIGASEEDILTMKQGVDGEKEGNEVIGLNVPPVCNQGNRNGSIVLARDGNICALYQGVDRVEGGNEVVEPVISLAAIKRVKMTVSFWKRMNTETLSCRTTIWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRX0</accession>
    <name>L7JRX0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994080">
        <property type="protein sequence ID" value="ELQ74050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3035"/>
    <dbReference type="HOGENOM" id="CLU_2706559_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRX0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="8740" checksum="5C2F35E7AACB0948" modified="2013-03-06" version="1">MRDYLTYHRDNVLAETSLNYNQKNKEKGSKNVEISHRDAKTTYMNHPTTLNDNIKGYRQNLHQLTMKCVREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRX1</accession>
    <name>L7JRX1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994107">
        <property type="protein sequence ID" value="ELQ73791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3293"/>
    <dbReference type="HOGENOM" id="CLU_665686_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRX1"/>
    <dbReference type="OMA" id="ITPCAIP"/>
    <dbReference type="OrthoDB" id="2195960at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="499" mass="56354" checksum="B0D7C44483C47680" modified="2013-03-06" version="1">MPTIFPLYTLTLTHNVVIAAGGGGDPLFGKKNGIVIMDSTTAKELIFFKTEDIIRSVRVYMSTQLVLPENDDELSAADYRAQEVRMERLSTCVVKGVCDAADNLAQLPSCTLYLTLVGMESFSHVKICGGEMHVLERYRMRVDQHAYTNFNIFLAQGKIFAYMPCVPWQVDRRRIKSQQEEYFYGLARKNDTVVVVREDGHIDVNDDWEGFFYKNRRIHKVVKEDVIAEEDAVAEGVAVKDARVRDSTDNNTNGGKNTDERAGAKHGSAVRNKNTGAEDKNDGKSTSVEDDHTNKNTSIKDKNGGKSTAPRQCYTFVFNLKKYNFDEEIVSPEIVSDHLVFYLKKSSKVVFIKEEVKEVEMERITCISNHKPDDECSTCPEKSTGTSGPVPRRTRCRECVRITCSHIKNRKDYFITAVGTASGTLYIFKNTVLVNKITPCAIPITSLAVKDNFVYYCSLNGLIDRRVIVKKRGFAVFVLLCVMIVGLALLFGFYRTYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS40</accession>
    <name>L7JS40_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding Cassette (ABC) Superfamily</fullName>
            <ecNumber evidence="10">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.44" evidence="10"/>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS40"/>
    <dbReference type="STRING" id="72359.L7JS40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2794"/>
    <dbReference type="HOGENOM" id="CLU_431619_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS40"/>
    <dbReference type="OMA" id="CHKEMDE"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="216"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="451"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="656" mass="75753" checksum="6E2999E622B39F5D" modified="2013-03-06" version="1">MQGSNNAYRNSSYVYDRLCDIACTYTDTIKKLCERSPHMSKPFQIFIFVVKEMFSPPLKPCFVIFTIVAIIFITELLLYKIRIENLRSLSSCKNYSTLRSFLFYTTICGIIYPTKFLVYQVIYSDYLERLSCRAFYTVLSRRWEITLQEEGLNSRFKNLGWLVESVTDNGIFQSFVHRGVKGMTNLIRQLVLSLLARIFSYFFVMKETNDQLGTTILLAIIFMIVITLLTNIIIIYILIYYRRRYNFLRAQLDNHVSECLSNHLLVTYCHKEMDEYQRYKMKVKNYRTAVVMLESVEHVLEILLYLITNITKFVVYYVIYKNNDVYPVHLVMFVMQKIDVIEQNTKWAGSFYEKLRKAILDAEFAYDFVSSSKNLKASHDSDLIIAGIGQSRDTCTDHGLSDSHSDEGEQPAAKRYLETTVTLPSKEIYYDENENVTNTAPSRNTKGTLIMQFRDFTIIMNQKLLFKPLNLSICKNDKILIKGPNGIGKSSIIRAIFGMIDYIGDVTIKGVPLQNINTSKLCAMMAICPQSPLVFKNTIRFNLGYGNCATDEGMTKMCKHMNLFDKLVEMEDGLDSLILSGGENFSGGEKKRLCVARAALKRCEIYWFDEPTAGLDSTNMHAVVDFITRMKGTVIAIMHTDEYDRCFDQVIYLERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS61</accession>
    <name>L7JS61_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein S4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994072">
        <property type="protein sequence ID" value="ELQ74125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS61"/>
    <dbReference type="FunCoup" id="L7JS61">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2953"/>
    <dbReference type="HOGENOM" id="CLU_089738_1_0_1"/>
    <dbReference type="InParanoid" id="L7JS61"/>
    <dbReference type="OMA" id="WIFKNIT"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="7">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="184" mass="21295" checksum="4B6985DA297D9D07" modified="2013-03-06" version="1">MVKSKGKKRYSTPLRPFESDRLIAEMKLIGEYGLRNKKELWIFKNITNTTKKRARDLLITNNNEELIVCGRALLNKLVLTKVFGDDVSLITKEDITKNLERVLDLEVNSFLERRLQHRVFELGMANSVHHARNLIYQRRIMINDRIVNKPGYVVTGDDEAYIRLKEIPEGKKKGEQVAEVAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS63</accession>
    <name>L7JS63_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3203"/>
    <dbReference type="HOGENOM" id="CLU_1636696_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS63"/>
    <dbReference type="OMA" id="DISHYNS"/>
    <dbReference type="OrthoDB" id="10377309at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="163" mass="19650" checksum="F73D3A3F6B0C78BA" modified="2013-03-06" version="1">MTYSLAFIKYSNKEYIFQSLKTLSDPEYDVNEKLGIITQMTEVILSNRSMFRDPEMQVIYHEIVRLLPDDFLYDGLIVFLGKTCLFVNRLQNILFENNIFDYLKYDKVETDAFIYSLCYRNYGLAKYYFEVKYRSGVDDRRLIVMLKDWYIKELSNGRYPQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSA7</accession>
    <name>L7JSA7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3132"/>
    <dbReference type="HOGENOM" id="CLU_3038215_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSA7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="6661" checksum="12D365A12577D5F2" modified="2013-03-06" version="1" fragment="single">VYDADSSFDDVYFARKSTDGYDEEEVLRYENEINRKDTREDVKRRKIEESYGTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSA9</accession>
    <name>L7JSA9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histones H3 and H4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSA9"/>
    <dbReference type="STRING" id="72359.L7JSA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2731"/>
    <dbReference type="HOGENOM" id="CLU_078295_3_3_1"/>
    <dbReference type="InParanoid" id="L7JSA9"/>
    <dbReference type="OMA" id="ANMETSY"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="6">
        <location>
            <begin position="55"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="144" mass="16883" checksum="26C9E1FC3897FCE1" modified="2013-03-06" version="1">MARTVRPSRPKLQSPTKRTRQPVISKVARKKSLSIKTPTVKQLPIKKPTKLRYHVEKEIKYYRQSITHLVPKACFIRMLKGMVLKMDTPMRFTKDALDMLQDAYESYIVANMETSYLATVHAKRVTLKPIDINLIRKIKDRQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSC8</accession>
    <name>L7JSC8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Apurinic/apyrimidinic endonuclease</fullName>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="JH994046">
        <property type="protein sequence ID" value="ELQ74334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSC8"/>
    <dbReference type="STRING" id="72359.L7JSC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2742"/>
    <dbReference type="HOGENOM" id="CLU_1070338_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSC8"/>
    <dbReference type="OrthoDB" id="2671967at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="260" mass="30835" checksum="788E0CDA741BA379" modified="2013-03-06" version="1">MHCGFNTKVKKILQKDGRRRHDIWIASNTYKENEKLILQTLEGLGYPKTFIKQKKRRYPTVNLKPIQNKRNSIKAITFNINGFRNKSEEVYAFLDRRRPDILAMQETLLSEERYRTYIPGYTTIEAKMTDREGGRGLLLSVRNNRGLRLSEYKSDPNYLAGIIEGLDMQKEKFSMLIINVYASCDSKTKRQTIQQVCRLVERELQRQKFKEIIMLGDWNDTPEKTYNRLTKQGMAFNDSFINFRQPTRFVRRTRRGRCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSU1</accession>
    <name>L7JSU1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">26S proteasome regulatory complex, subunit RPN3/PSMD3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSU1"/>
    <dbReference type="STRING" id="72359.L7JSU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2733"/>
    <dbReference type="HOGENOM" id="CLU_062465_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSU1"/>
    <dbReference type="OMA" id="YDICISK"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="353" mass="41602" checksum="51510BD46821188F" modified="2013-03-06" version="1">MDTLTQILKAPDQQTKCNLLSQHLPALLTADIKGDSLIAFLLKILKMQQREEHAECIKKITKNQNNLSGVRRENDWVVSYIVRACFISMKKLNDYDLRLFCNLLITNRKYGNAKTSLALNNIVLKILIEKKMFWYARNYLNDEYCDDSKYNLYKGIVRCVSMEYEDALRSFRLAMALSDRYTSKVRKYECVTLMLLGRMDKSYRWCKSLCAYKEACDAVKMGDRKKLGRVIEEYKSAFWEDKTFFLVCRLHHLIVQEGIRKISLVYTRISLQDVQEKYGIAEELFTRYVKDRKIRGIVQNGVYISGSVPPLRRTLRLLDTLRLNEKCSERMRYPRIKKINYENYVKNGEGRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSU7</accession>
    <name>L7JSU7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">20S proteasome, regulatory subunit beta type PSMB1/PRE7</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSU7"/>
    <dbReference type="FunCoup" id="L7JSU7">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2599"/>
    <dbReference type="HOGENOM" id="CLU_035750_1_1_1"/>
    <dbReference type="InParanoid" id="L7JSU7"/>
    <dbReference type="OMA" id="CSGCWCD"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="243" mass="27887" checksum="14E55F410B77C741" modified="2013-03-06" version="1">MSFFREMLVTEDNPFKIQEVANKGPKKHLDVDDLYANNSGTVLAFKQQDYVIIAADTRHSSEMGINSRKMTKIFEFDGFIFSGTGFYADLNEVYFRLRYEVERYENEVEKRIGISALAHKLLNILYSRRGGLIYYVFSVLVGKDETGEPVLYSFDPIGSYEQVMCKCYGSASPMIQPLLDSTIMKYNQENASYQSLCMEESVELTKKAFFAAAERDVNTGDYLQIVVYKRDGVNEELVDLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSY3</accession>
    <name>L7JSY3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal recognition particle, subunit Srp19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSY3"/>
    <dbReference type="STRING" id="72359.L7JSY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2648"/>
    <dbReference type="HOGENOM" id="CLU_1950448_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSY3"/>
    <dbReference type="OMA" id="TVFMPRT"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="131" mass="15025" checksum="F01F2A0C680D9F35" modified="2013-03-06" version="1">MTTFAVYPCHINAALSHKHGRKYNKTLCTSNPTIQEMEKAAAALGLQFTVEEKKIHPKTPLDPGRIRFSKEYGRLTVVRGLKQEIEELRIVKVEKEIAKKENVKAKIGTTVFMPRTKKKKNEKKSKKTNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT26</accession>
    <name>L7JT26_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_2497</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT26"/>
    <dbReference type="STRING" id="72359.L7JT26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2497"/>
    <dbReference type="HOGENOM" id="CLU_527457_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT26"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978997" description="Telomerase reverse transcriptase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="53"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ74584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="517" mass="61214" checksum="D2E9FEED6E1C36BF" modified="2013-03-06" version="1" fragment="single">VFCNLLFLIFDKLFIPLISTCFYSTEGFQNFKVFYFTRKAWSFFTKIHLQEFLARFDIKKKSTGVQYIPRCIPKKDGFRVIVNKSKRDKKGKSENMILQSAYHILTKEQELDHGNSFIDYTQIFNEFMRYDFSASFILKFDIKGCFDSIPHDNLQAILIDFLKSDEYYVRRYNSLIKRGRYCVNKKMCISIDNSKSFADIVQNKEAKSNELIWDDVYVSYKRKECLIEEICKVIRENIITFGKEQYIQQKGIPQGSILSSILSSLYFQSLDTSLFNKIVKVGRIFRYVDDFLIVSPSLDEMLSILSSLKYLEKDGVTINYKKIESNFGIENWLFNNQQIQNLSQNKEHVKMLLDAVPDKNKFVTYCGLKLCCRGFKINLNFERIEHSCAYSSAKPGQMTKYKVNRFLKKILKDMYFVRRNAFKYQNLYDVFIFVFRKILNFIRKMDFVNIKFILSIVNRSKNQMRKLIRNLGTDVTEKKLKLIKNKALKDSGLKLFLQKIEINISLKRQKRIFGRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT37</accession>
    <name>L7JT37_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridylate synthase</fullName>
            <ecNumber evidence="2">3.5.4.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.5.4.26" evidence="2"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT37"/>
    <dbReference type="FunCoup" id="L7JT37">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2575"/>
    <dbReference type="HOGENOM" id="CLU_016902_12_1_1"/>
    <dbReference type="InParanoid" id="L7JT37"/>
    <dbReference type="OMA" id="THKHEPP"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="362" mass="42108" checksum="66224374ED626FC5" modified="2013-03-06" version="1">MTHYFYKFDTQVKGRWVGRSIIDVMSNEFTMKPVEYYDEAIRIGNITVNNEKSDKCRILSLGQTIQHLVHYHEPDACEIELLCLEDDYLVVNKPSGIACHPTSGYNLFSVTRVLEKYGNLSCINRLDVLTSGVLILAFRNAKKYHNEMINHRIKKIYLAKVKGRFHDEITVSASLKKNRFNFTEVSEEGKKAKTIFKCLFFHNGYSLVECRPVTGRSHQIRVHLKSLNFPIVNDPVYNDDTNGIIDENVADKENYLDDLCTSHDTEYVSKRKIVEKKQEHRLDYRDKQDKTFCATNCIFKRGCGTPGDYTAEEQFAIDNCRGNNTRSFRNKDKFICLHAYKYAFNGKEYMAEPPFWAKKDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT41</accession>
    <name>L7JT41_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT41"/>
    <dbReference type="STRING" id="72359.L7JT41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2580"/>
    <dbReference type="HOGENOM" id="CLU_2098536_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT41"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="116" mass="13329" checksum="A8BEE2DEC3E85A3A" modified="2013-03-06" version="1">MFRMTLLLFWSAGFSAIANTMVILLVFAQYLTMEYIGVIAFSILVVFYILLVAPFLMIYYGVVEWYTFIPTGMFVFLFVAMIVSGEALRRRRHFYKRLSECVSTTNYLGGGNTKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT76</accession>
    <name>L7JT76_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT76"/>
    <dbReference type="STRING" id="72359.L7JT76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2544"/>
    <dbReference type="HOGENOM" id="CLU_1555234_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT76"/>
    <dbReference type="OMA" id="MMSNSIR"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="180" mass="21165" checksum="AB169BC118630AAF" modified="2013-03-06" version="1">MMSNSIRDIFQYSKEYDMSNGIPLKHNKYNRYFRDSTKYDLDYFGLTFSQRLGCFFIFFVAAFLSFVYSLFNILGAIVSPAKFALPYAFSNFLFFTMIGFLVGFRKYFKSTFSQNRWKYTTTFLVCTFLTIYSAMKIKSYFFNFTMAIMQIGSFVVFAITYLPKGTERLGDVLRFALSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT78</accession>
    <name>L7JT78_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2555"/>
    <dbReference type="HOGENOM" id="CLU_3015877_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT78"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978713" description="Transposable element encoded protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="6433" checksum="70F82081C514EBA0" modified="2013-03-06" version="1">MPRRRPGKQIFIFYTDAFLCLCKEIVFVCENTVSIQFHDDEMKGSSLGFSNKALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT92</accession>
    <name>L7JT92_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LTR Retrotransposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT92"/>
    <dbReference type="STRING" id="72359.L7JT92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2458"/>
    <dbReference type="HOGENOM" id="CLU_897675_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT92"/>
    <dbReference type="OMA" id="HTEGNEM"/>
    <dbReference type="OrthoDB" id="2194752at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="77"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="310" mass="36531" checksum="28CF48FD091CB7D1" modified="2013-03-06" version="1">MFDFGIVGEVPGKENTEKLIIEAHLKANYRGLEPTYYELKERYHWLGMKRHITEIIKRCETCQQNNRKHTEGNEMVSTTRPLEKVAIDIVKIKEETVMIAIDYFSRIIWVRDVGNRRKETIIEKMNELVEEWGVPEMIITDNTKEFVAIETKNWMTEARIIHEKTSVESHKSNGRVERVIRTVREAIEKMELNEMGKAIKEVEDRYNKTYHAGIKCTPEEAWKDITGIAAVENSKDGRYNKQFKKRKREKFAEGQQVIVAQKENLRDNDKIGRFVEKDEVIAVCKGDSYLIRRSGRGILKKRHYDLRARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTD0</accession>
    <name>L7JTD0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994049">
        <property type="protein sequence ID" value="ELQ74301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2778"/>
    <dbReference type="HOGENOM" id="CLU_1363333_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTD0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="201" mass="22238" checksum="3642DD106B83818B" modified="2013-03-06" version="1" fragment="single">VCEGTSEREDGESLQGGSILQPTGVRVDRRKPMRVDRFVTYKLGSFTGANHELFAFLVTNMRIDEIVDGEADRVAELLFADVKAAVMQVRRMDSNLSYGLQGAGRSLGRGRREGTSLADDPEDEERPSSFSVTLPGRYVAILASVLSTSRCFGRYVKAIHLESFGGKSGMMTHSVIDLYARLEEVADFRLSPFVRIDILPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTE1</accession>
    <name>L7JTE1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994032">
        <property type="protein sequence ID" value="ELQ74664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2415"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTE1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="952" mass="111277" checksum="CE838F4BF1F416D3" modified="2013-03-06" version="1">MLYNITDYVTATVIYIFVFKPTLSEKNEYMVFNNLEHTQMSRFITFLEQEKVTNKHFSVEQCNIDQIINGNAISKTNADLNEIEPESGDSKPKRAKIEQQPHTYYDYIRSYYNENRSYKIVRLPFTKKLYQKILASGSIRATTFEQKDYFDIFKYVFLHLDDNVELLSEMCESIQENPTEFLRLFENDSDEKARSNSFHNFTTDCTCCNSERCIETFWESVNTYIICRLKLNQKYIAMVYGENSRECGVSLNKELENFNIGFFFQCLQVEYDTLRENIAEFHKAFQNRPRNTTLTIIMRVFRPIDELKPAISGKYSLNDDITELLQHEFFKQKYIEKVAIKVESDKLNRNPVKNKGDYPYDYVTYLKFTIDFKNNEIQPIRDMKVCISDDIYAINSTKFANLSRFTIQNVKFAQTLTFSEKWKNFGLYNFEGNPEKTIHVRSGREKLIIKETIGRFDLSGTAGFSKVLLSKDSEFSFKKRQTSTMSSLCLVQLRIDTPITIDRNIVCVVIAEIECNDIITLEITSCHDNIEIFDSKGIFKFEGIFCAQLNFTKNTFLGIEKIHNIPRMCFTLYCCAINDAVQLPDYYNTIELKEININNNFKINNGCSILRIFCCRGKIVIPEGTHLKVLKIVFDPIKYNELIIEGMPDVNELILQDLCCDYSVITHILNQLGNVMFLKIVCSDEQKVNTLSFEAYLNKQYVSSPYFENSSHKNQQNEDEIILDDVSSSQIIHRIVQNFLNAFHKCKLISRIHGLTYIGVLMSNHDLQQYSMHAANLKALDAGIEYLTNNSFEYMPQRIEFLNLCDSCTPDENLLSKFENLKNFDKLKVIVVDAVFVANVTNFQFLPESTEVLMFKDFGWGDRSQIEKEITKLKLRKLYVFKEVEEGTKVDEQVINENLRKILETLGHYVEFENLESFVVVDRKEHYEIDPVSFNPINQYRRMLNMRIGENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTG1</accession>
    <name>L7JTG1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transport protein Sec61, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTG1"/>
    <dbReference type="FunCoup" id="L7JTG1">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2529"/>
    <dbReference type="HOGENOM" id="CLU_031763_2_0_1"/>
    <dbReference type="InParanoid" id="L7JTG1"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="11">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="473" mass="52933" checksum="511B902944E9B30F" modified="2013-03-06" version="1">MAFRALSLIKPFVPFLPEVQLPGREINFQEKFVWTGVALLIYLVSSQVPLFGILNTNSADPFYWMRMMMASNRGTLMDLGISPVVTSSMIMQMLSSLEIVRVNSKVKEDQTLYSAASKLLAVLLTVGQSIVQVSTGFYGPTSDIGIQVSLLLVIQLFFSGIIIILLDELLQKGYGLGSGVNLFIATNVCESIVWKALSPKMHTTARGIEFEGSLIALFHLLFVRKNKLYALHEAFFRENLPNMMTLTSTLFIFALVIYVHGVRVNLRTESLQVKGQQGNYPIKLLYSSTMPIIVQNYIISHASTVSRFLYQKFPDVFLVRLLGVWTMRKNGKMVPISGICYFLFPPDSLMDIFRKPLYFMVYTSIVLLSSAFLSRAWIDMTESNQNDVARSLINRRVTIKGVPERNLANKLGEYIPTAAFLGGLVIGFIVMLSNILDTIGSGTNIFLAVSIVWQYCELFNKEAAKRGGLLVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTK7</accession>
    <name>L7JTK7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2988"/>
    <dbReference type="HOGENOM" id="CLU_772049_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTK7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="359" mass="40800" checksum="20CC9CA0C48346D8" modified="2013-03-06" version="1">MIFKLSMLYYEIALSFMTALLIFLGFKLFRPLVENEQKDLIKPDNEISLEEDRITSVDSEIERDYEEEDEHTGSDEIVYSLSTEEDISYLPPTESIDTSEALALEPLNQILANNDMTESKLIGENTKTVRNLSNERDVTKLLLTDKDSESATKTKVSKKRNDNSLKHSISSSDTQPGSLNCENSVEEFLKVRALQKQCGSSAVRKIVDFSDEHNDKSDDIDDKCQVDAMHKHGNDAGHECKNSLIPTYDNVRSSKDISDELNDHGAWISSIDKGERPKVNTDQHASRILYTFEVTNLAYQPRLNANQADENHTFDNYTSNREEDSSLESLRSFGNDMMPPVYKRDGNPKQSLHEFPTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTL4</accession>
    <name>L7JTL4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2285"/>
    <dbReference type="HOGENOM" id="CLU_2851317_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTL4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7384" checksum="F0074EF47C0D8CCB" modified="2013-03-06" version="1">MAGYRIAPVQKIIDKTVSDVIVSPANFCWASTCEELRSESIEVEAAKAKVRTFTMWIRSRTLYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTM2</accession>
    <name>L7JTM2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JH994021">
        <property type="protein sequence ID" value="ELQ74818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTM2"/>
    <dbReference type="FunCoup" id="L7JTM2">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2250"/>
    <dbReference type="HOGENOM" id="CLU_004962_6_0_1"/>
    <dbReference type="InParanoid" id="L7JTM2"/>
    <dbReference type="OMA" id="PSHGLMC"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="551" mass="63136" checksum="8EAC94D2F6B2B001" modified="2013-03-06" version="1">MEELPTIQEVDDSTLKAPLLSTESASDTKTDTTLSIDEELLEKYGEDLRSERVANVFLPASYVLDDKILRDQKKNCFDSDVIRIHFFNQGKLSESQASKITKAFIEMVKKEPNVIYVDKPCTIFGDIHGQYYDLLKIIKNINFDHETVVFVGDYVDRGSFSSEVFLFLMALKLAYPKNVILLRGNHESSEMTRYFSFKKECDIKYSNNMYKEFLSAFRALPLCAVVMKKIFCVHGGISPDLKEIEDINRFNRFVEPTSNKTMLDLLWADPHPFYESLETVYFAPNKNRRCSYFYTYLAVKEFLAANNLWCIVRGHEVQENGYKLYKEYIDDVPSVITIFSAPNYCDVYKNRGAVIKFDGEHIQIKKFKEDEHPFILPGFIDAFNWTFPFISTKIGELLLDLLSVKPSTSSSSSVSGIDENIKQVQTFTTAMSLLREEREGMNEFVDEESTDLSTENIKGVVVNEDDNFTEVKIKDIPNEVFKTKDNLTKSMSIETVPSFAKDISKEVENADLNAVVEESKIVETESKSVKVVVPENPKKKPSLFSCCFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTM6</accession>
    <name>L7JTM6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.15</ecNumber>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.2.15" evidence="3"/>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JH994018">
        <property type="protein sequence ID" value="ELQ74823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTM6"/>
    <dbReference type="STRING" id="72359.L7JTM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2242"/>
    <dbReference type="HOGENOM" id="CLU_324173_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTM6"/>
    <dbReference type="OMA" id="MHTAESS"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF925">
        <property type="entry name" value="UBIQUITINYL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="150"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1097" mass="124798" checksum="D4EEBAB47CBE3666" modified="2013-03-06" version="1">MNFKWNTTLPKKQHKNKSPDFEVDGRIWRIILANYDGAYVSLEYRGTSVIPVHTIIHFVINGESFTLSYEYNRFDNYFGRYLFRNDEDGEHESNRDENNNTMGDRTVISMHTAESSAVFRSAYQIDDSIEIEVGVHLVCDYDSKMSTGYVGIRNMGATCYINSLVQVLYNINAFYNRVMSTPTQPEVNEGVADKALTGKDFIDEGVASRTGKALTEKGAPTDLNEKGAPTDPNEKDAPTDPNEKGAPTDPNEKDTLKNTPKHEALKNTPTDHEDKTPTKVDARREEKRTNKYNLKALQQMFYKLRTQQTEVHPDLTFRNLSLLGPLDQHQDFHEYSKKLLDELEHETDDQRFNSLFDGELTQYIRASCGCTKESVEKFNDLQLDVRHSIKEALDAYFEEDELCGDNKYRCDEHGLVDAVKGQAIRKVPDILFVLIKRFSMDWETNEVVKNNGYCEFGDVLEINGERLVLKGVVVHSGVSSDGHYYCYVRVAHDDSTRDATGAENTTRNTTGAENTTRDATDAGNNTRNKTRDATDAENTTRNATRDAAGTAWSKSNDHVVAHDNRAGTVWLKFNDHIVTRVSESEVLEHNRGGRHPYRRAELPFSAYGLFYLKNDAVPKQPLTDEQIARIKTNETRAYNCNILTKESVKGYSGPGFFNTTCDYPRTQPYTMNSTNFKRMNAEKKYHYVFEVRDGMLCTKVRWCDNVLIFSVFTNVQYDFVNEHRLVFVKRFDESGGVEYDYGGGMRMIDVVVVGRTESVGGVVRRYIGNEGVEVVIEKVRGDYDYDEGGDGCDKGGDGCDNDKGGDKGSDKGSDNKDITNNPNTSPNPTVTNNPNNNNVNINEYVDLSDRAVKNGTIAIICSNARSAALHLRYLSQRRCISFINRNKSFTLFLKRTYTYNEVARIVREYLMDQKVAIAYFKGNVHTLRTNQIPFYTADDRRLVYFGRGCLDYNRIRHIHVLSIDKSLTVRKFKHTYRPSCISNLTDYYVVECVVNTPVIRVLADEDPMGSTDGLLVLENTRGKYFKACHAVCVDGVYQVTGFPFLFFYEDERTVGDLRVRCGCLGVLVVYDGEFYREMENGDGLERRDEEIVFILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTR6</accession>
    <name>L7JTR6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase (Reverse transcriptase), Non LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2286"/>
    <dbReference type="HOGENOM" id="CLU_1399410_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTR6"/>
    <dbReference type="OrthoDB" id="2205812at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="195" mass="22720" checksum="9B83E8C24672F360" modified="2013-03-06" version="1" fragment="single">VPHERLFAKLQSYGICGKFLNPIKAIYRRPMGSVKTGDKCPKPFYYKTDVKQRCLAPPILFDLYINDQFDVLTGIKVEPKTSVPGLLFADDTGLFAEDYDKTKICIPRIKQECEKRKMELNITEFGVMRFDTEATATIKYKIIEISQVSSYRCLRLPIDRKLNMNTITNDRKDRKLRAFRMIQAFLQELVIPWPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTU6</accession>
    <name>L7JTU6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding ADP-ribosylation factor Arf6 (DArf3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTU6"/>
    <dbReference type="STRING" id="72359.L7JTU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2361"/>
    <dbReference type="HOGENOM" id="CLU_040729_15_0_1"/>
    <dbReference type="InParanoid" id="L7JTU6"/>
    <dbReference type="OMA" id="LTANCKN"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="130" mass="15079" checksum="D638C478704E4C16" modified="2013-03-06" version="1">MGALLSRLYYYREKKVIILGLDNSGKSTILSQLLKYPKKRTIREPYMPPTLGFNMQKTTFKNRKYSLWDLSGNNNIRKYWKCYFTGCNGVIFVVDTADIDRIDENLSILGELVSDEELKQAAIFSFFAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTV5</accession>
    <name>L7JTV5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2164"/>
    <dbReference type="HOGENOM" id="CLU_3015876_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTV5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6901" checksum="A07D5CF6CF896CA1" modified="2013-03-06" version="1">MSQLPHKKIKLHKDKTKYLKRSKKDKSIGYRLTKEINRKMVDRVRMRQKNDMEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTY5</accession>
    <name>L7JTY5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTY5"/>
    <dbReference type="STRING" id="72359.L7JTY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2191"/>
    <dbReference type="HOGENOM" id="CLU_1176132_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTY5"/>
    <dbReference type="OMA" id="NIEGLIC"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="236" mass="28539" checksum="140B7EB3FB05BEA2" modified="2013-03-06" version="1">MISPFYFSFIKRHKNFSKIENLRLFYTGDIFTRILIRLKKYKPYSIPFLYPVKKKEAYNYYDIIKHPMDLQTMLKRADIYDEQSFRHDLNLIYTNCITYNIEGLICDYARELKQYGEKLIEEEFERQMVMTENRKMVVCTGGDEWRDVTGRVVVRTRENDVKEAMMKWLAAILMKRFVKVDGCVLNVLKDVVMWRMRVLIVKWRRMRTRKDGAGLECYVKVKEMVNEVERSNTNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTY6</accession>
    <name>L7JTY6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subunit of tRNA-specific adenosine-34 deaminase</fullName>
            <ecNumber evidence="1">3.5.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.5.4.12" evidence="1"/>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTY6"/>
    <dbReference type="STRING" id="72359.L7JTY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2294"/>
    <dbReference type="HOGENOM" id="CLU_2378578_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTY6"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="95" mass="10894" checksum="758962D3E2AA5E77" modified="2013-03-06" version="1" fragment="single">VDGQVLAVEKDRDDILNHGILNAVTAVSQQQINYLCTGLDAFLLNEPCVSCSMAFVHGRIRRVFYVNNGTGTYSRQRMHEFKKFNHRYAVFRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU05</accession>
    <name>L7JU05_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="6">dUTPase</shortName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU05"/>
    <dbReference type="FunCoup" id="L7JU05">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2102"/>
    <dbReference type="HOGENOM" id="CLU_1994208_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU05"/>
    <dbReference type="OMA" id="YNNNRCA"/>
    <dbReference type="OrthoDB" id="10261072at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="7">
        <location>
            <begin position="43"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="151" mass="16312" checksum="8207F33D40EF44E6" modified="2013-03-06" version="1">MSSDITSHPQNLFLKNAVHTPRMFKLHSSAQFPPQRSAHTHKLFAPQSTSIKAHQTALLPLGLKTAFPSEYFLFITTTRSPLVSTGGVIDSDYRGELGLIVCNAGDCDVTVERGECVGEGVFFKIVVPVFDVVEVLDDSVRGSDGFGSTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU12</accession>
    <name>L7JU12_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2267"/>
    <dbReference type="HOGENOM" id="CLU_2475144_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU12"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="88" mass="10257" checksum="A6E19C8BF2A4C519" modified="2013-03-06" version="1" fragment="single">VFIKKVQHNFEKMCLNYTTAIEDVAKVKPARIRISLNLYSNTKQLLQEEDSFKDLMKNARNQLKDFNDLFILLATKPSNILQRLADVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUA6</accession>
    <name>L7JUA6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994009">
        <property type="protein sequence ID" value="ELQ74890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2177"/>
    <dbReference type="HOGENOM" id="CLU_1504501_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUA6"/>
    <dbReference type="OMA" id="FWFELAD"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="179" mass="21259" checksum="45A93743A11145E6" modified="2013-03-06" version="1">MLLYIFYGFILGVVTAPVLVEIVMLYLIEKFGRSRYSFKPDRTRMSPCQKDIFRQSVHTTKDVAWFNVWIQRHWYELAHSYAHKDRISRIILKKLNVLKRRKIVKDVIVENLELSVEAPIIESVRVLTPSQYNDILRICDTTTSKSTVEEVEDRLNDGSSVNDRFFRMCRERRMGIRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUB0</accession>
    <name>L7JUB0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2541"/>
    <dbReference type="HOGENOM" id="CLU_3034055_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUB0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="6480" checksum="660F550608131AB9" modified="2013-03-06" version="1">MNDCMCLDDCREDNMNDCMCLDDCMEDNTCREDYRVRIVMDILTLNVIKLQIAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUF8</accession>
    <name>L7JUF8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1988"/>
    <dbReference type="HOGENOM" id="CLU_2055397_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUF8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="13823" checksum="6F31115D54641960" modified="2013-03-06" version="1" fragment="single">VIDHVLKDTLSCGSSYCRKAVYQGLRVDCTAMWVAKLRTRVFPKWKASRTTIGELMNQLFKCSNAIWVTGTETWLHRLLHYEIPITQREAIQAVKSKLIERKLHTDGCAIDCFKQVNLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUG9</accession>
    <name>L7JUG9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Heat shock protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUG9"/>
    <dbReference type="STRING" id="72359.L7JUG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2092"/>
    <dbReference type="HOGENOM" id="CLU_068529_3_0_1"/>
    <dbReference type="InParanoid" id="L7JUG9"/>
    <dbReference type="OMA" id="HTFFIDK"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="150" mass="17766" checksum="1018699A9195CCFA" modified="2013-03-06" version="1">MLPAKDYFTLLNLPHTFFIDKQTLKHNYYTQAKRYHPSMTGGNDNMFVGLKKAYDTLNNDLKRALYMHNSVHPAGARSALDADAADLSHVYELSERLSANDKNAQAELAERIDECKRFYYDPVYLGRWRYYERMRERMKDKEIDMRMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUQ0</accession>
    <name>L7JUQ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUQ0"/>
    <dbReference type="STRING" id="72359.L7JUQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2317"/>
    <dbReference type="HOGENOM" id="CLU_855545_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUQ0"/>
    <dbReference type="OMA" id="WKILIYQ"/>
    <dbReference type="OrthoDB" id="10348917at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="313" mass="37267" checksum="654D4D0FBEEC88EF" modified="2013-03-06" version="1" fragment="single">VFVVICSNFLISDPLMIYKSDLDDDDISDTISQKYPALCQFLKSPDNNLLLEILTYPCLAVLKKLIKSKFTKLAEPKNLLQLIEKMLPYNSTTTILLINLLRYCNSQPFVSEWIRRIRTTYDDLLQQTSFTLFYNYVIDNDTKNFYCEYFIKITPQLESYIEFFLSVNNNHEFYINLLFEKEITNKEIAQNTLNYLVNLEINDNLILLYNSVVKRYNLDEYNINLKEVKDIIDDIKKLNLKRYFAIIESGKPYINKEFYHITLLQSRKWDGYLQILFWKILIYQRIAFDWTVPDDNNNNDFGKDALMVLDNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUS9</accession>
    <name>L7JUS9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diadenosine polyphosphate hydrolase, proteins of the histidine triad (HIT) family</fullName>
            <ecNumber evidence="5">3.6.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.29" evidence="5"/>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUS9"/>
    <dbReference type="FunCoup" id="L7JUS9">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1841"/>
    <dbReference type="HOGENOM" id="CLU_056776_7_1_1"/>
    <dbReference type="InParanoid" id="L7JUS9"/>
    <dbReference type="OMA" id="DAIYGMM"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015964">
        <property type="term" value="P:diadenosine triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="149" mass="17241" checksum="9D7ABDCFD84DF9CC" modified="2013-03-06" version="1">MKFGQIDIPEEHIVAETASTFVFVNLRPFLKYHLLVSPIQPAISLRDMSEVQTADLFNTARICMKAFEFYAKDFTMTLQDGEAAGQTVPHVHIHLIPRLPDDLEVNNDIYRKGALECNYDGGRDRPNRSYDEMAQEALYLKKKFYTYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUT5</accession>
    <name>L7JUT5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA helicase, nucleoside-triphosphatase</fullName>
            <ecNumber evidence="8">3.6.1.15</ecNumber>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.15" evidence="8"/>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUT5"/>
    <dbReference type="STRING" id="72359.L7JUT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2278"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="L7JUT5"/>
    <dbReference type="OMA" id="RYLERKM"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="169"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="374"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="773" mass="89861" checksum="03E78261C8C9F6BD" modified="2013-03-06" version="1">MSVARAKKNLEKYEDKRRKDALRSDLYKRINMASTACCPPEQNILRNENSKRSNKADCSDKQGKKRRDYDKFVRDKNPKDGNTYVKKHFCEKGQETLRSKDDLEQLEEFQHPINDNGSQYGENGTKSSNEVAEEKDKAQIYGGFCYNRREKVKRMREKLPIVYQEDEIISLIREKSVVLIIGSTGCGKSTQVPQMLLENNFKGILMTQPRRISCVSISERINYETNEQVAAYRFRFNNNVTPTTRIQVVTDGILLNEMIKDAMLSKFNVIIVDEVHELTINLEILLPLLSRLVQIRKDLKIILMSATPNDKIANVFSDHGEINLKSALYSVAVHYSGVCLQSCLQNKPEMAEGWKGKEEGNHLNLYNRIKNETEIIDRVVEIVNKKEGSILVFLTSKTQIYSLIRSLKGISDQIELIPLHASLPLKNQQMIYSNKRKCVLATNYAETGLTIPGIKYVIDCGYEKNCVSNGTLRSYPVVPISRASAEQRKGRAGRTGAGECYRMYSPVFYEGMRKFNTPQVESNSLDHFLLVLFHFKVKHNVFINRPDNEKLERSRKVLERIGAVKNLKITKLGRLIVKYPFEPRLSVILLKYDFNEIKLIISILDSDIEIRREDFEHFYQNETSDLLIKAKIILFCRDLNDYRENNHKERLNTNKNMFEMRKEVSANKTSNLRGKVKDLLEYDNLKEKKFNFTEDVENKIAKILFVTYHDHLCRRIHDEYYFNGKQVHIDRNSKDVISEYFVFQYLTERNGKLYAVNVTDVDKEWLKTDNLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUT8</accession>
    <name>L7JUT8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dCMP deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="JH993994">
        <property type="protein sequence ID" value="ELQ75085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUT8"/>
    <dbReference type="FunCoup" id="L7JUT8">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1981"/>
    <dbReference type="HOGENOM" id="CLU_047993_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUT8"/>
    <dbReference type="OMA" id="CASDVES"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="117"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="261" mass="29558" checksum="3BE493057F874AB0" modified="2013-03-06" version="1">MLICIYTREKETSSYASKYLSERLQCPILVPSSPELCFPHQIKYGVLTLASIAEWKKYEVSCSLLLIIFTEHADPEFYDDVCALNKFTYKIQYINGSREKLQLRAQLDRIRLEIRPAWETYFMDIATFVSHRSACAKRNVGAVLVKGNRIVSTGYNGTAMGTLNCIDGGCPRCCSGTPSGSNLDLCVCLHAEESAMMGVVSERLSGCDLYVTLFPCMLCAKKIIQAQIKRVIFKNYYCASDVESRKLLEELKIEVKRYIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUV3</accession>
    <name>L7JUV3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RhoGEF GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994018">
        <property type="protein sequence ID" value="ELQ74821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUV3"/>
    <dbReference type="FunCoup" id="L7JUV3">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2240"/>
    <dbReference type="HOGENOM" id="CLU_018585_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUV3"/>
    <dbReference type="OMA" id="WDINTAN"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="6"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="732"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1015" mass="117105" checksum="3F7E357F304E60F0" modified="2013-03-06" version="1">MKQLRKRLEALSEIFESEKAYVSDLKIWGEDFKRYLFQSETLTIEKKHSLSKTLFINLDAIIALHEQIAQELGRRNEYIREINKLPTGDAYKPIVVNDDTAVMYKDLEYHSVYYKYLNRFGVYRYYVSRLPTVEFDLDKECNMNRFFKQELMDFFNERNIELGPKHFIYRASQKLARYAILWNAVLHYEENPVFIEGINETVQKLKEIARDVDQTYGSINESYKIFRFSADLHYSEAVKNRIPLNLFQKQRKILKEGDLIIKYRYIKEPKMLRFIVLDTVMLICDVVKQGNVEIKYIITDPLPLFKYIVTERNIGYTFDNAYLESMNPLFLLERAGTDIVVIFFKDERLKKMYFDVIHGAMEEIRRYFRTNVDLRPLLEKTNHEILCCSTRDTKFSINAHEEGEHTPHDTVDIADGKEVKEDKDVVKDSKGVVEIVDTYIDTVDDNDEDRRLNVDKDGDRDRDGDGSDDRLSVDGKDESNGKNSSSKNTNTNTNANTYTNNTNNTNTNVNNTNDKVVQRREGDGMNNSIDTNRDIANNALAVRRNDNKPINDDRTGSACEQCTGTADHNGRTSDKGRNIDNGRTSDDNNGRTSGNGRTSDNSINNNDNNDNVNNDNDHNNNNNINNNDINNVNTNVNTNDSEEEQSMSTTGDNVGSKKKERSQSVIVENNRPPRRLRFATQLDSDKDSGSSSSSDNDACSAEQGQRKLSFFKRMLGQNAPDETKDQTFNIGEGDYRKIFRSDEQFLLFGTKEGLFKKIGPHFVSLYDKSVQKVVYDVANKIIIFLETSRICCAPFVPDQNTLHTKLITRRADDFFYGITLNKLTIAALTVSNNSTTSVSLFKVTIENRSVSVLMDRKLFVGCLVFDIAFFNTKLVIACRDFEMVDSDTLKTQELVDPLDLCVPFYFKELKNITALSVFTIESDVFLVCYDCMGFFIDSYGRTIRQNVIFVWYIRPIKFKIYKEYLVCVSDQEVAVWDINTANMVYYTRQEHLMFVAGSSSLLLYDQYSLYKLMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV20</accession>
    <name>L7JV20_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin class II heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JV20">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1709"/>
    <dbReference type="HOGENOM" id="CLU_000192_8_3_1"/>
    <dbReference type="InParanoid" id="L7JV20"/>
    <dbReference type="OMA" id="RCYFASK"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="11">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="65"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="792"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1435"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1603"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="158"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1658" mass="189677" checksum="80D836FB9753509A" modified="2013-03-06" version="1">MADTMEEKIQQKDKKLIWAPDKERAFILAQIREEDGEYYAVLTKDGEERRVRKVDTQKVNPQKFDAIDDLAGLSYLNEASVLHNLHMRYTAHEIYTYSGLFLVALNPFRNLGIYTEKVMKKYSMNKKYELRPHIFAVANDAYTSMVMNGKNQSILITGESGAGKTENTKRAISFLAYVAQGCTASDGTSIEHKIVDTNPVLEAFGNAQTTRNYNSSRFGKFIKITFEGGRITGAYIEKYLLERSRVTRPGPNERNYHIFYQLLKGADSALRSALCLTGTISDYKILRNTPHSVPGVDDAKEFANTLRCMRSLGFDERTIEGVLRIVAAVLHLGNVSFVDTGEKGELADRAPAEAACRLLSIPIASLVNSILSPTAVLSHETVTRNRSSEQAQRIVDALCRLLYEGVFEEVIRIINTCIRSPVGSTYIGVLDIAGFEIFKKNGFEQFCINYTNEKLQQFFNHHMFILEQEIYKKEQIEWNYIDFGLDLRPTIDLIERNNPIGIFAYIDEECVMPGADERTLLHKLCTNLKAPEFEKGRFNDGFMLKHYAGVTEYAVDGWLAKNKEPYFEDIFALIVRSDDDLVRRLVARPTKGEKKGFFRTVAQKHKEQLAYLMQQLRNTAPHFVRCILPNCRRSAAEFDNHFILHQLRCNGVLEGIRISRLGYPNRMDFKDFVERYRVIYKEFDGFDERAYVKALCDAQGVSADLYKLGLTKVFFKQGVLAEIEEVRERALAELMREIRARIRAFVCVKRTHIDERKRSAALALKKDVLLHLALRRYGWWRLYQIVKPLLDVTKKNELAKEQLSRIKQMEQEMKECTQEIARLNAAVKTNQNEKDELAASLEKERLLVEHKDELITAIRAERQSMSEQLSAAQQEQHALQEQLKERARECAQNEQLLSTAQAEAQALRSQKDVLAQRYDALNEEHRKMRVNRQSLEDRVNILTAEMQAMSVKNVEQLVLDKEKELIRTNNLLKQEEERRRALEEQLGTFKENVHVLEERLEEERARAEQQAAQNNALSAQSANNAQRVHALTMSCAQQESAVRSLKEELANANKALSIAKNDAEDGAVLNQKLREELRKLSGELRRKENELQHAQELVHMEEEKSAALAARVEVLKGENEALPAPGTAAEIERLNERLKKAEKTNRELNESIAAEKAFFKRLEEERAAQHKKNLSEMQGRYAELLKDAAKTNSERKALSMRVSRLEHENADLRASLEERIQEDSTGSSECNMSVLESERKVRDELREELAQQEDLNMQLRNELEALHASFEKEVGERDALINELKARAVNKIGMQELYALRRELKACQRALAEALSTCQGTFNTRIAKYKAEIVALEQDGRDLKAQNYELKNKLGEMSMQAEVHANTNRNLESSLAFYKKSAEDAAERLQAKDAELSKCRNEGAELRARLSNAHIKHEYALKIAEERAKDVSGILADREARIAELNEQLSKFAQEFERLSALIKESDEEKALRAENARLSKECAQLHVELHALTTDNDVLKEHINRCEQSVLDLESRCSALKKENELKRSMMQCKEQEISNWKAQCASAAKELQSIALEKVPVPEFTPVQVNSVPEQRNEVVDVITYENGELKARVAERDGIINALTDERDAIKGEVHELKKAVEILELKNKQLERELADEKDANKLFKMIRTINKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV42</accession>
    <name>L7JV42_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
            <ecNumber evidence="6">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.19" evidence="6"/>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV42"/>
    <dbReference type="STRING" id="72359.L7JV42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2162"/>
    <dbReference type="HOGENOM" id="CLU_030988_12_2_1"/>
    <dbReference type="InParanoid" id="L7JV42"/>
    <dbReference type="OMA" id="WKPTISI"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="152" mass="17384" checksum="E2B91E763ABBFB43" modified="2013-03-06" version="1">MSTHLDRLLAEQANLKKERKYMFFARPSSKDATKWDCGFPGPDTPLYKGSYYLVSLSFGRTYPFKPPNVKFVHRVFHPNVYLSGDVCLDILGSGWKPSFTVSSILCALQQLLITPNVNSPANGPATRAYGNKEVYEKEVRKNIERWHTKLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV60</accession>
    <name>L7JV60_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1752"/>
    <dbReference type="HOGENOM" id="CLU_2851315_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV60"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7718" checksum="0733012F8282855B" modified="2013-03-06" version="1">MGCKTFPRHNPRSFTSMFHYLALYASEELHKRPFSENFTVLCMKEINKLIFSTKIFIGLNYMHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVG0</accession>
    <name>L7JVG0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1607"/>
    <dbReference type="HOGENOM" id="CLU_1016351_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVG0"/>
    <dbReference type="OMA" id="CECANDE"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="268" mass="30840" checksum="653EEAAB06FB0711" modified="2013-03-06" version="1">MRIFPSIYTILVMPSTTYTCYKPSPGGDHVTLYNIRTLSAVISDCVVKTSILQEKIHQNNSADELRCFVEYTGTLLRKLTELVEYYKTTKLFSHVDSIIDAFLTSHRCIYELLFVIVDNTEANLSINMKEKIENINNMNFIISQMVHRSRNEYSSSSIEKISTSATVLFLIEGDLKVLAQAISKLIFSNENININEVVKNQIVHYEECVIGLILVIHGAEMYNLQNGTCFICECANDEEFLYLSDNNNWIMCHFCFLRAKYMSEDIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVG7</accession>
    <name>L7JVG7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Cyclin, Cyclin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVG7"/>
    <dbReference type="STRING" id="72359.L7JVG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2021"/>
    <dbReference type="HOGENOM" id="CLU_963773_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVG7"/>
    <dbReference type="OMA" id="EMDISEM"/>
    <dbReference type="OrthoDB" id="10390287at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="304" mass="35402" checksum="F9AA3FAC594E7CD7" modified="2013-03-06" version="1">MSSDHWCYHSPQKMLHYSITSEYYRTKLLASPDDIHDFMKLSRAMALKRSTFIMSVNLFYRMLITRPDLKSDTLKCSVILLSCKIMENFRGISFITEAAKNYLKSVPGRKEIIHTELIISETLNFDYKYIDYYSYCESKVLSITRDKSLLICTFSFLTDCSFLPLLAFFKRRNVALACIFLALKVLKPGAFKSKKNVETDCSNQEIAAVITTGMKISIDSNDRDSTPAVQNLAIESQKRRKLFYRKLKKTYGNNEKSARKYFPYLKVEQEFLRDLESAFEGLKYSAIEIHFICNELLDLYIEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVH8</accession>
    <name>L7JVH8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2340"/>
    <dbReference type="HOGENOM" id="CLU_2352426_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVH8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="97" mass="10701" checksum="ACC1FFB77F024B2E" modified="2013-03-06" version="1" fragment="single">VSDQSLPCVDGRSGPVIYRTHARITNIASSSTYIMLGDTNDTWCHKAILSIEDREQACHAGMGRFKRSMNDTSACRQRRDDATVNENVCVTAPEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVP6</accession>
    <name>L7JVP6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Actin-binding FH2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVP6"/>
    <dbReference type="STRING" id="72359.L7JVP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1672"/>
    <dbReference type="HOGENOM" id="CLU_981991_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVP6"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="284" mass="33643" checksum="2A5FD1EDAE456E19" modified="2013-03-06" version="1" fragment="single">VIKDSRRLFLVSISLKTFEKKQLVLQDQQLANLPLEDLTMINTIIPTDEEYKILCTHKKDLNDIERRMIVFYPYKKLIRLLIFERRFFENKDSWIIGVENIKSVYDTILQSNNIRLLLKTVLELGNTINTNYGNSRKRASAFRICSLVLTKNYKGKRSDQSLLKFVAETARSRLKSIKSDLETIESIRNDELGNYKEIINEYILEYRTSKEWMDSLSGELRANMKAFLFFFSQFVRNFSNEYREAVIYSSIIKRKFGEPENKNVKEIIAILYDFLKSIRHEIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVS4</accession>
    <name>L7JVS4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mg2+ Transporter-E (MgtE) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1647"/>
    <dbReference type="HOGENOM" id="CLU_059050_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVS4"/>
    <dbReference type="OMA" id="NLEFCFQ"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="65"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="397" mass="43818" checksum="C77698B1C2C7066F" modified="2013-03-06" version="1">MTEHTTHNEVLAHDQEPPIYSKSILSQSIPSLLISLVGFTIAGIYLEEANGTEMFLSYPLLMVATCILSFKGNIELIFAMHLSSISNVYNPVIEYARFAIDNSCMVVVQSIMIGLSVGVVGMSVVILRFDDAFRYAVITLCSCLVSCLVSTLVVLLILLAAVLLFKNLQINPDNVVLPSIAAFSDYFTVLSLIFFFKLFHRMQSVTACATTILLILVVVPFIMQVSRRSPAILPIQSLTLLVITFVLSSISGMLIEYFSLMYPFLASSAPVFCGLTGSTSFIYLNRKLTSLYTKQPHNKKASLFSLLIISLAMSLTYIIILNTLFERLPSTFSFLFIVCFLVDVLLLIEVVDYVLSHFQRSVEMAGVVALPVITSTADFFGSSFLVGIVLLMSMISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVU6</accession>
    <name>L7JVU6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1466"/>
    <dbReference type="HOGENOM" id="CLU_2043787_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVU6"/>
    <dbReference type="OrthoDB" id="10506053at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="14045" checksum="F74220A2B8C47D33" modified="2013-03-06" version="1" fragment="single">VRRVCYDILGSELAVKQKSDIRSDNMNDNVEKSMKPTNTTSQNNTASIKYQVLTLPISKALYEKVLHLSWTSDTKFTFGEICDLLTMSPRFFEKEALIMFNVFKNIVSDRSLFLKLNQFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVV5</accession>
    <name>L7JVV5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2189"/>
    <dbReference type="HOGENOM" id="CLU_689260_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVV5"/>
    <dbReference type="OMA" id="SYREYEM"/>
    <dbReference type="OrthoDB" id="2194517at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="400" mass="45778" checksum="4D002116732ADCD1" modified="2013-03-06" version="1">MFALITMVKSLRNFIADSVTRLSSFINSSMVEDKTGSEDADWHDLGESEEKETVLFDDSISFSRDIVDDGKDRIGEDSVRKIDTERKERMNNEMGDGRGAGEVRDEGMDRGKKRKEDDSENRTVRNDKVEERRIVSQKIAGDGDNDVERGSYRLRGQNYGQSTECGSMSICGRGVVNTDTMGGSRSSRNQAVSQSMIDCGAEPAKSRNSVIYRSTGIHNYPIVPHQAEITCNQSTYIDECNNTQQSGVITLSYREYEMIERRISFLEDELRREVSRNAHTNTNHLLSALQEKDTKLSVLMDQINKLTVNEHRYKLQITTLEKDLTRANDRANAFKVIADEKVHCTTMENESLRDQLEFERSKNARLRSVLKEKESDARKYAMMNVEMVEYFRFMVDENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVX1</accession>
    <name>L7JVX1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell cycle control protein (Crooked neck)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVX1"/>
    <dbReference type="STRING" id="72359.L7JVX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2148"/>
    <dbReference type="HOGENOM" id="CLU_786582_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVX1"/>
    <dbReference type="OMA" id="HKIKTHP"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="308" mass="36378" checksum="683F18219B799A11" modified="2013-03-06" version="1">MSTYAKKIQLIRNHYNHKIKTHPHNTAIHTEYALFEELLNEYNRSRTIYENAVAHNHSNTNLWKNYACFELRQCDINRCRSILERAVQMNPREISLWLFFAELEEDMMNIAGVIDVYGRMVAENNTEDCYWHAYNFYLMVDDGLANEVLKTMDEKFAGVRIKVEKLVRMNDFSVVPALCDRWESMDDKTYVKIVDKLEKAGRLQDAFIFVKRGKYRFGSKFFKDQYKKMSTGVVDEDDDAHCSALLCEAARLEEQKEICAAEQMYKGLLNVINRKYRTKSFILYSKFLIRREKLQLARKTTDERSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW24</accession>
    <name>L7JW24_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1854"/>
    <dbReference type="HOGENOM" id="CLU_769841_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW24"/>
    <dbReference type="OMA" id="DIACEME"/>
    <dbReference type="OrthoDB" id="10445143at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="311" mass="35867" checksum="A31AE970293983FA" modified="2013-03-06" version="1" fragment="single">VITNGCALLAEKFEELEENFGSDIACEMEKLLLTLKSEIHETINDGNEALKLEFLHVFEEATKSIIEYINKVSRWEYAETDKILSYKCSELTTNIECLIKDVSNKIKKTVYTFNQAEEEDIEAIIRKENQKICTQIEQILCDTHNFDPIIPQLVFPDPAHIASIVSSDKPKLLEEIKKLMNQFIEEAKLEISQIEELELHDQKKIMDKGVAMVMNALEEIVYETLDLIEKKVCSATNKESRTLVESIYRNYSLLEEFITIKASEMTKNTEEIICEITRLEIKAMEVEIADYNDKIAGHFKGKLSCFNYNMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWB3</accession>
    <name>L7JWB3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Homeodomain-like, Homeodomain-related, Homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1727</name>
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    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ELQ75341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWB3"/>
    <dbReference type="STRING" id="72359.L7JWB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1727"/>
    <dbReference type="HOGENOM" id="CLU_1631132_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWB3"/>
    <dbReference type="OMA" id="MCKSSTR"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
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        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
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    </dbReference>
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        <property type="entry name" value="LIM_Homeobox_TF"/>
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    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="94"/>
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            <end position="95"/>
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        <location>
            <position position="1"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ELQ75341.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="163" mass="19236" checksum="73F33BBB48FC5BB6" modified="2013-03-06" version="1" fragment="single">RKICPCSMGRNSSFKAVKFIDSTHEVLRSYNKPQTSKRRRTKLTEEQLNILEESYRINHHPSSEIKEAVAAKIGIPIKNVQIWFQNRRAKDKSIKEHIIAESKRREDESYYTTNRRINLDFMARGNSVSTHHHDYNSSARDYSMYRSNSRNSYDGSYSSHEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Goldberg A.V."/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Goldberg A.V."/>
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                <person name="Weinmaier T."/>
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                <person name="Becher D."/>
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                <person name="Schweder T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="ELQ75793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="188" mass="21940" checksum="8DD63304226C10C6" modified="2013-03-06" version="1">MQKRIKFLTPMLISAFRNLFLKKRLTASVSRNGTQVLTDASLDLEGTTITLQKDTKTLKYPIEEMQSTTRSGNKLMFDYRGSHIVIESASLNDIYTEIQPLLPNTKVQAKSTVDYYFLEDKEFVLCKNGVDLEIVHELQDFIKIKDERIYHFEVIRADMQFYMDKNKKSFVWAGADFKTYMVVFYKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWF1</accession>
    <name>L7JWF1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposon-encoded proteins with TYA, LTR Retrotransposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2006</name>
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    <organism evidence="1 2">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
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    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5289" checksum="13C8F1B1398BB54E" modified="2013-03-06" version="1">MERIVEAKIGSSNLTVLDLKEGYYQIEIEEADKHKTALEFGNNVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWM9</accession>
    <name>L7JWM9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1587</name>
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    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993956">
        <property type="protein sequence ID" value="ELQ75466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1587"/>
    <dbReference type="HOGENOM" id="CLU_2759598_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWM9"/>
    <dbReference type="OrthoDB" id="10610583at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="70" mass="8072" checksum="6C922E1A5A74A45C" modified="2013-03-06" version="1">MEEINAPPRATPLRDPHNNRKVCCNRNSDPNTQVITWERPPSQEYPEEFLFSGIFTCDQFLAISHPAKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWU2</accession>
    <name>L7JWU2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993984">
        <property type="protein sequence ID" value="ELQ75187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1871"/>
    <dbReference type="HOGENOM" id="CLU_494476_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWU2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978862" evidence="1">
        <location>
            <begin position="18"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="523" mass="59569" checksum="8225F7FABDD0B59B" modified="2013-03-06" version="1">MRVTVFILLSIYRGIYTAAGDVVTISSGDDLSDENKLMQATSNDYGNKKSVISSTSLSQISTVKDELCLPSDINVLSQTHYLPASETLISSILERASYKEDRKECSIPTCSYFLTEQRPLFQEQNDTDSYLVGANNTHYCNPHSSNCSGSVNPDACAQTSGITQPSNSLRHDKPVDLNEVSCNDNNMCDIATFIQCMEQKLFYNISCPYSDFISLNQPNFTREIFQWHENAVCKTSFDKLFLRHHKKLNKALDNQQKTFLLIDTCSISRILDIKLPQSSDKHFFKASVAKFQASWLIFLLESRKYFNNTFLKCKDLHVTLQRIETIIKQALKMNIKLNNTELMASLIQLDNEQSALFNAFIAHISAENDLFMKIFVNMRIVFSSLNENVRDNLNVMDEMNKIRKYVYDDVLDILIIPRMSNAISFGKSLVLSVKNNVEQQNSIGYSNNDVVLINKGTDTTELCTTMTVNEHEIQTSKVIMSYMDEYKKLVSLICTLNEICEHLNTILNHDLNFIEQIVNNLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWZ0</accession>
    <name>L7JWZ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993980">
        <property type="protein sequence ID" value="ELQ75242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1813"/>
    <dbReference type="HOGENOM" id="CLU_3263271_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWZ0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="5134" checksum="9ACC6C7FB9039785" modified="2013-03-06" version="1" fragment="single">VVCLFWVEVFYGFKQVSMYSNMHIMVKRERWAPCVLLYLYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWZ9</accession>
    <name>L7JWZ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Transcription factor, enhancer of yellow 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993977">
        <property type="protein sequence ID" value="ELQ75252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1800"/>
    <dbReference type="HOGENOM" id="CLU_2456469_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWZ9"/>
    <dbReference type="OMA" id="MTANMPE"/>
    <dbReference type="OrthoDB" id="2190341at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="98" mass="11790" checksum="C274997EAC1C8CAD" modified="2013-03-06" version="1" fragment="single">VFFLAINYLPRVRMLQTSENLISEETKNKLLNLLDLHMKRSGFHDKIMQKMESLKINENINIEALYKEIYDFMTANMPEEVQDAFFEDVRRIMCNERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX39</accession>
    <name>L7JX39_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1794"/>
    <dbReference type="HOGENOM" id="CLU_2514230_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX39"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="10330" checksum="AD64D0AFFD799D15" modified="2013-03-06" version="1">MSRNSLPDLYLFFLALRQTEDKYLAYKKVKESILRKQEEVLSREYPLGDDEYERIYSELVRLNDKCSKIDELNRRNVNNDKEEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX60</accession>
    <name>L7JX60_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0968"/>
    <dbReference type="HOGENOM" id="CLU_1548701_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX60"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="173" mass="20366" checksum="31434EAF711696CD" modified="2013-03-06" version="1">MVLCLASNSLYNKTSYSDLEFNKEKISSDKDVNPNRYLERKENCVNNTFERKTAETSSDDENEEQDETGTADEAHNENVRNLNIKLALFKIHNYGSDDKNAQGTFSALNLKRRIEQIDKYEKIRRKIAKILKRNALFLKYLKMLNKLNQSYLNEIEDIRKEKEEMEKSEGERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX86</accession>
    <name>L7JX86_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993968">
        <property type="protein sequence ID" value="ELQ75357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1700"/>
    <dbReference type="HOGENOM" id="CLU_1566702_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX86"/>
    <dbReference type="OMA" id="AFCYENY"/>
    <dbReference type="OrthoDB" id="10423159at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="171" mass="20176" checksum="771867B65E40A1B6" modified="2013-03-06" version="1" fragment="single">VLVNKDRDTKLSEICEDKCKKCVFATDYNLSHLIALLKEKNVRKAAVCGYNCIPGKFVVKDDGRVECYGKNEEDITHAFCYENYNPLYEPYNPCLPNDNRPARLEFVFRCPPPYRPPQYPYPNYPCPPPEWTPPYNPYPCYFFGSNCFYRPQHSAHANDYDRNDDNHYWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXH3</accession>
    <name>L7JXH3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
            <ecNumber evidence="1">3.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.8.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JH993930">
        <property type="protein sequence ID" value="ELQ75736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXH3"/>
    <dbReference type="STRING" id="72359.L7JXH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1305"/>
    <dbReference type="HOGENOM" id="CLU_059493_1_2_1"/>
    <dbReference type="InParanoid" id="L7JXH3"/>
    <dbReference type="OMA" id="FQQMFEP"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018784">
        <property type="term" value="F:(S)-2-haloacid dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="227" mass="25842" checksum="5AEF096BCA7004A6" modified="2013-03-06" version="1">MPIPTRPQIIPMSTPPHNHQPPIHYPNLFIFDIDNTLYHSKPSLTSHITTQALSKLSINHSAARQKILRECREQYGFSIKGLYARNLLDYDTYCEVIDGVDYGAIVGCDGDLKSLLGRLDAGKICFTNGERMHCMRVLDALGISDAFDYVVCVDHKDPDFLCKPMEQAFDLLERLFSVKNMTVFFDDDPRNIAVAEQRGWNAHCVSSVQEMKALLVNTYHEYLRDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXI3</accession>
    <name>L7JXI3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1279"/>
    <dbReference type="HOGENOM" id="CLU_2160178_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXI3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="111" mass="13338" checksum="674DBEAB3364834A" modified="2013-03-06" version="1">MKKNMVNGKETLGTMILPEGIFRKKEDYVDVQHYLRDLQRIFGEIEKMYVSSKNMIGVQKIFYYCGEVVCLKNHYVHLFMFTLLLNVLLLHYRLFIFHKRNQLKRGKNLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXN0</accession>
    <name>L7JXN0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993877">
        <property type="protein sequence ID" value="ELQ76080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0943"/>
    <dbReference type="HOGENOM" id="CLU_1180919_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXN0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="235" mass="26719" checksum="0C18CBD674F85654" modified="2013-03-06" version="1">MMDGYNYISQKIGGTYTYLRSISADAYDYTMDKISKGYNVVRNGGTNVFQRITDWWKSYGIGADGSKLGFFGSLWNFIKSIYNWFFGGPGNSNDNSNPLLKQDVNNNSLTDQPAQKPEICDDKKDPTSADNMTPDETYLMSRNAKRIHEWNAYAIRKPYLNKMDVIVPYEEKGGNGSPPGTNGITGKDNTDNPEKYDQNLKKYLSVLTVGFMIFMSGLFVYSYFRESFHYILALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXN4</accession>
    <name>L7JXN4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative BRCT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXN4"/>
    <dbReference type="STRING" id="72359.L7JXN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0824"/>
    <dbReference type="HOGENOM" id="CLU_704343_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXN4"/>
    <dbReference type="OMA" id="ITIDHPC"/>
    <dbReference type="OrthoDB" id="10379484at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="392" mass="45580" checksum="CE0FCD2E83F508F5" modified="2013-03-06" version="1">MPFPHSPSNKYDKAIECFMKRLYTFIKCQMCHQNTALYQTNSNKIICSQCKEKGRFKECIFAHMLFDLRKYFVINVFDRNPILSTSSVTEKSCSESNVCAKPESDHTSVETINNGNDKEHLEIPKLSFSLSSYLESSPLKSNPVQRPIRLFTPTNDSSSFDFENFDCPLKPTFIDLPDSQTKTALTLQPAVLSFSSFGKQKKQPKIILKRIIKHEIEEIGNIYMCFSNLNEYQHRYVTKKFPIYKKKYKNIFLCRRMSDQVTHLIVNTEGNKCIRSYKYLYAGLRGIFILNFAFFIDFENQIESRCSWYQFLVDGDLAYGTNSLSTNIFRKDNLIFENVNFIMDKRTTNYQVAKLVQLGGGTINSKQDHFVNITIDHPCEIYDYISSNKKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXT2</accession>
    <name>L7JXT2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXT2"/>
    <dbReference type="STRING" id="72359.L7JXT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0780"/>
    <dbReference type="HOGENOM" id="CLU_073630_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXT2"/>
    <dbReference type="OMA" id="RNPLNNM"/>
    <dbReference type="OrthoDB" id="2189509at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031537">
        <property type="entry name" value="DUF5092"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17010">
        <property type="entry name" value="DUF5092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="41108" checksum="FF7F52622C89B6FC" modified="2013-03-06" version="1">MADLQVDFYSKAYEIDTVITIRGGPNNTRAREQPVMDEINGNESETFTLEEFRKIILDFRKCEKDFILARVTTPDPYRQDVLYNYYYIASEVNKVLFKYESTRRLLHRMKVRNPLNNMYIIGQVYYYHITKEEVDRALVDCFFRNKRLRNKEGRRAFSAVFRSVQNPAPSDTFLATSKDTDFPRQKQPKEDNIKPAKDIIEDVRKGKLRVPERDITPLLVNYNAYFFATDDDFLLKNDTRDYFKMNSIDPSEDFLFELDRTENDLFAILETPSSSENDEALSWKRMLTFHLSLLLTLVGVVLLLGSFPVVLIIAFPLVVIVFLSFLCSLVYILCIRRNSFDSLAVRSVEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY15</accession>
    <name>L7JY15_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA recombinational repair protein BRCA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0670"/>
    <dbReference type="HOGENOM" id="CLU_285698_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY15"/>
    <dbReference type="OMA" id="NTINRSY"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCA2 OB1" evidence="2">
        <location>
            <begin position="851"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1084" mass="122192" checksum="098052D258800132" modified="2013-03-06" version="1" fragment="single">VMRIYVGTVLLFRMLMKKSIRIRLKVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIRDFDGNIVTLRNKNGNNDVVTTTNFEDYLLSNGKHSSTSESSELEGDKEVAVDMEGNVIQLPERTNGLAHDIESLTTSLHESIGLVDANANILTTPVSESSDNEMNDGRIALNVSPGTKNEDDKTGTINDPSTYHNFVDGCPTDQTNSPTEESVSSTEDQNQDEQNSTGHSSPYTRASKQELNSLIHNTALFFDSRPYHNNFEVEIELFPNGVLSQTSIQSRGSAPLPDVPQHHTNMCSIMKTTNTGYVKGVPRKTIRAQYLQYEWENMSSEFLPKGNSARKYPMAKDAVEQESISSTELQEDDLAVGQLINSPENGPCAEIERVCESLPDVQEEQQPSVSDSFDSEDVSASDSDFSSLSDDQNKNIRPYHDLHESSGNSELIDFSSFLTQPRSDEIVDVTEQRDPLQSETLFSSLKNEARHGSSRADEGSLSVCAPNVGNTSMLTGFTTANRKKIYVNEDSMLKMTKKLEQGSQNIEKDLGVSMNVFDEENIFDDTRLKGNAQVKVSVMTDDCVFSEELNDKSKEVQNEKIKRKKRNEPVDVEDELDSDQSGINGNAERSCVKEVNYQKTVQVGLKDQTRNTSDQTDAKHGMQKGIENRGSKRNLQCFANKTPGEDEIAGNHERRTQNKQHSAIKYLAKEENGAKKVEIDDIVPIDRNGITKNAPMRMYGKPVKGHTTLEIQKNKNIEEIYTKIVKKYRNQRKEWIDEQFKWAYLSCFRSSNLEKDIADRMEARRLKEYSILRRIIEGDDVCFKLMCLVIIKTGSSLELYDGFYSLLFKADKALQGRIVAQKLKVGDKIYVFNAELLTHEKDIFAIDGPAFQLHANSVMRVKDDIKLGYTKYMSFLLKFTNVDKMGGLVPAIEFIITKVVDDKVLIQCHGLKRAVNVDRLEEEIEHMKTLAAKHGIEGEFKLKRYSKLLIRDLHSCQEGIFTWWNIREEVKVGDKIRAISATIVSDTVGLHFNTINRSYVSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY41</accession>
    <name>L7JY41_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide excision repair factor NEF2, RAD4/CUT5 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY41"/>
    <dbReference type="STRING" id="72359.L7JY41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0618"/>
    <dbReference type="HOGENOM" id="CLU_1161852_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY41"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042479">
        <property type="entry name" value="Slf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677:SF1">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="239" mass="27527" checksum="252DBD6F45DF8F04" modified="2013-03-06" version="1">MGGRTKQKYDYTVTHIVTQHDSLRKNAKCVRVEWVDRCLYAMRRCDERISIVRVPRTRSVTYNTHTMVQFTGIPPALKHTLKEQLNALDIKCADSEHMQGVTHLVSGSLATSEKFLCAMVSGIPIIKPNITCTDLDSLMWTEDDADDNDKKIVRAVMYWRGVIRRTHRLPFSGWRVRLLCTKARIGSYQRVLVCGGAEIVDEKWTHCFKSKDYDGEDVKGVRTTDYIFSYLFSHTSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYH3</accession>
    <name>L7JYH3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanophycin synthase (L-arginine-adding)</fullName>
            <ecNumber evidence="2">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="2"/>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0672"/>
    <dbReference type="HOGENOM" id="CLU_049340_3_1_1"/>
    <dbReference type="InParanoid" id="L7JYH3"/>
    <dbReference type="OMA" id="EHMYQEY"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="21768" checksum="931510283CD801B2" modified="2013-03-06" version="1">MHLRCNNLRCHTTIQKYILITPCSHIYCESCSPKIQSMQMCIACKTTIRPDDLIVQELTKPPSIVGYPPDDILECARDAISFWMYQAQQQEYVMKSMAENTRADAEKAAQDLKACRLKAAIEKRNMKSRVRKLESSLKRERENVYDLSMMLREKADEYKRQQMRRERKEMNMMSYEGCDSTCEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYH8</accession>
    <name>L7JYH8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">mRNA cleavage and polyadenylation factor I complex, subunit RNA14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYH8"/>
    <dbReference type="STRING" id="72359.L7JYH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0678"/>
    <dbReference type="HOGENOM" id="CLU_544228_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYH8"/>
    <dbReference type="OMA" id="AQLEYYV"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="4">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of forked" evidence="4">
        <location>
            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="501" mass="59763" checksum="5227D0373E5D0135" modified="2013-03-06" version="1">MFYSPIYEHAKWLYRTSKLSKLDDFLKTHLSMSYNVYLWQLYLAHVFQNMPEKLLDAYEYALSHLEGHFDITLILRDYLCLIDSMHDQDVVDRKRAAYQNVIKYAVFCLPAIYKEYEEFEYKLNKFTAKTILEKVSYNYKGHKRLSLTFNANKEIMDQVTLENYSALFEVDERKIFVWKCLKEKFYYSEEIYFELIRMAPNFVVEAIFCNSFVDHDEHSNTECILQNRENTFTRANFFFVLLGAYLNKIDLASYIFKENFLSNWKIGEGDSRPDTAKIAAIGDLKDSFRGIRIRNKDLVYIHFLDTVFKNKGISAFRCVFRDLKDLIGPLVFYYVAQLEYYVYGDVNVFVNVMLLGSKKSRSLETYMIKFLVNHRQENLARKYAAYFGRREALRQYLYLYTFEPQSAENENATRTESLNDFYYKGGFEYEPFILRSKGNKAFNEMVKTLEFEELRLYKHSLLLEMMEDVRKDESIKLFEVVHPECVVKLLRTAEIRPKNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYL4</accession>
    <name>L7JYL4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1204"/>
    <dbReference type="HOGENOM" id="CLU_2074781_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYL4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="13648" checksum="8DD4D0DEFF1E52D6" modified="2013-03-06" version="1">MKKKKYHDIDAYNLSHFCDNDPESNQDTQDRRKNGSDVASQESSKSSIDNAKSTETMEDVDEKDSMQSIKSSENQYLKIPKDQGHAVKRPVIYKKNFVRCLSPRQYYRTAQRSNVAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYN7</accession>
    <name>L7JYN7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993913">
        <property type="protein sequence ID" value="ELQ75857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1185"/>
    <dbReference type="HOGENOM" id="CLU_1714698_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYN7"/>
    <dbReference type="OMA" id="SKYGECV"/>
    <dbReference type="OrthoDB" id="10330359at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="17480" checksum="767DA1C3C4E23A6A" modified="2013-03-06" version="1">MPSNTLTIKHIPSVPLSLIKQYFSTFYPCTVSQSTNKTTITYKTAQHALYTRKVLTNTALNNHTITFILKSKARVYVRECDEKMAYDRASKYGECVVGRKGQGCIVTFERFKNADEFVESGGGEYAFKNGDERWGSVSDREEEEMSDDMAVMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYQ8</accession>
    <name>L7JYQ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993867">
        <property type="protein sequence ID" value="ELQ76156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0872"/>
    <dbReference type="HOGENOM" id="CLU_1431288_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYQ8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="190" mass="23022" checksum="539051473E7034A4" modified="2013-03-06" version="1" fragment="single">VSEQTERSPEQEENAEYERYLIETNRFVKSRPQLYRVRTFEDFEVILKSGNKELVARFFIRRLTEKLNEFCVNDLFETIEKAFHIFMKFYDEERGMLDHYDLLKYLPVMIEAQIITIIKFLEPKIFWKRRSLEEMNGALALIKKSLKWKGYNYEYLLDIYSPRIREHEQIRLNTAKTEISKILNGTQSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYT1</accession>
    <name>L7JYT1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993863">
        <property type="protein sequence ID" value="ELQ76176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYT1"/>
    <dbReference type="STRING" id="72359.L7JYT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0849"/>
    <dbReference type="HOGENOM" id="CLU_1454043_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYT1"/>
    <dbReference type="OMA" id="FGPCFAY"/>
    <dbReference type="OrthoDB" id="2186329at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="166" mass="18655" checksum="4ABE3DE394CBD036" modified="2013-03-06" version="1">MQQTYKYMRFRSTPNIHVETNGLTVSSAADNKSCLTNEAIEDNTYFEVLINKLHVRIGVAPQDYKLYGPLGLDGSYAFGSLKGYKYHKGVRNAYAHKLKENDVVGVLKVEHFLKFFVNGVDLGIAYDDLYGKEYFAALSFYGGGSVCVNFGPCFAYDSVIKYEGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYV1</accession>
    <name>L7JYV1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1098"/>
    <dbReference type="HOGENOM" id="CLU_2832979_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYV1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7837" checksum="3A82DCFA957A60CD" modified="2013-03-06" version="1">MRELPEEREKSVYKRILESDVFKRSIIVSLYGIILMLCTFLAMVAEAEESKNLKDVICHVWCRFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYY1</accession>
    <name>L7JYY1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding cell division cycle control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYY1"/>
    <dbReference type="STRING" id="72359.L7JYY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1071"/>
    <dbReference type="HOGENOM" id="CLU_034743_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYY1"/>
    <dbReference type="OMA" id="AVHIFEC"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="470" mass="53748" checksum="9391E49269AA75B7" modified="2013-03-06" version="1">MYVQQIKTALKYKNYTQAIFVLTHAAHKEETLKLILGIVLYENREYYRALSILSSFNTITGMFYAALCHREMKNYADAIDALLHVINGDAPKDTLDACWADYVLDGNSEHVCALLGELYTLNEQGDDALVYYRRSVGLYAPFMALFYERALDEHVCARLPGFFAQFAADLLEFERCSNMKIVHRYAALMPGIGTYFVSNAARVLFEHGDVRRSVRCFESVHKNDGTYTADYDSYSAALWLDKNVSALACVCRTLLDKCKHVHVTWCALANYFSLRNDHNRSVLCLKKSLNVRKTAYAYLLLGHESIIRNEYEQAQLFFFRALKMHRNNYNALFGIALVFSKTDQIENADVFFRKAVEVNGHNKVIRYLYVKYLVDNKKYEKAVDVVKAMYGVEGCELGALVGQLTQLGCKDEYDELVMLEMVDVLVYYEMVGDAQRCLDGVNVRGAGYRCKKDLVDKMIAAKENKAYVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYY4</accession>
    <name>L7JYY4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ER to golgi transport protein/RAD50-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYY4"/>
    <dbReference type="STRING" id="72359.L7JYY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0802"/>
    <dbReference type="HOGENOM" id="CLU_035820_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYY4"/>
    <dbReference type="OMA" id="AEHETIF"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="479" mass="57222" checksum="EF8E935333BDA236" modified="2013-03-06" version="1">MHSFTNFKNQLQRAGRQIKDDVIKGLESAVESLMFKEDNLVDLLIKMEDMYAIEQFFHECIFVNMIYAKIYDTFSFHFFTQKETNRLDKPEWYFKFLLDQLDKYKFVCACYDSVVLENKKSKINKNVISQRLQEGFLEENELKSNERSMNSLIERIYSIVEIKLNELRKCKSGQKRNLLLHFTEEYLVFKRELREKYSVNFNIMELADNIMRVQKGYIANNLHEIHCGDSKEWFESYQKIYKENFFLAFSYVSLQNNIFNDLIDFISSLIVEYQEVFIDKMSFVGKEEKRMLCFLVVGIDKLKNFLRLEESLFILQLENKTVDFNVEILKNIHIDTLKFIDFNNSNIKLLKTIAYHEISQVLVNLMYFNGITKKSLVQSCSELSKIMTFYNEQLGPYKILTESYIFDKIDNFIIDKIVLQNRFDSDVLFMYKDLVQRIMHMCEKKTDWMCLKACKNLEDIFNGVTEGDSLFKKIYAVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ10</accession>
    <name>L7JZ10_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(d)CMP kinase</fullName>
            <ecNumber evidence="2">2.7.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="2"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ10"/>
    <dbReference type="STRING" id="72359.L7JZ10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1000"/>
    <dbReference type="HOGENOM" id="CLU_079959_0_2_1"/>
    <dbReference type="InParanoid" id="L7JZ10"/>
    <dbReference type="OMA" id="RAITWWM"/>
    <dbReference type="OrthoDB" id="10263145at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate kinase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="228" mass="26214" checksum="B813CD501E572766" modified="2013-03-06" version="1">MGKIFEIAIDGHAGVGKSTTAKAIADFFGYTHINSGDIYRAITYVLLSKYENEKQAFKKGLNEEQLNFLHTIRIENHHNIFFYMGEVCKLRTDDVNVFVPYIAQVKEVREHVHTIQDRLIQQAPRGIVMDGRDIGSNIMPNADLKVYLTASAEIRAMRRFKECGGDYDEILAQITSRDYMDTHRKHAPLIKTADALEINNDHLKFDEQVKIITDRVEEIKRKSPDPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ30</accession>
    <name>L7JZ30_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ30"/>
    <dbReference type="STRING" id="72359.L7JZ30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0300"/>
    <dbReference type="HOGENOM" id="CLU_607204_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ30"/>
    <dbReference type="OMA" id="YNELACR"/>
    <dbReference type="OrthoDB" id="2188625at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="451" mass="51560" checksum="4BFB1D0691020A27" modified="2013-03-06" version="1">MSCSRTNDFRYVQALTGHTGCVNALAISRNIGRYLATGSDDKRIILHDLFSANFNHQPAVLHGHENNVFSIKFGKQDNHVYSCGLDGFSFVYDLNKSNRPFYRGGNASEQAYKIDVKKDNDNLFAVASTQSLELFDLRIRAPYNELACRQQLSTVNYHPIEQKILIASMKGKLDLLDERKLDRPYLKYNTALRYYPSFFQQRASDAVTLFEEFSFSGNETIRLELPISNATFNYNGELILASPLFFFPTLYRTSDADPQVVFYARELRHVWTMKNFNFGGPYDKMILAGSDKKLGFFWHLPDTFCTGFEHAKQRQDRKQHAFTRQGRCVNQPAANVTLARDVLLAQPFNEAVSDTVDFFSNSSYAGIQFRDAKRSFEVAQTYGKLLNAKGMINSVVMHSKMPLIFTAGVENIVHVYSNLELGHITKSYNRNSETLNIFEQLLQQNNLNDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ59</accession>
    <name>L7JZ59_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="JH993823">
        <property type="protein sequence ID" value="ELQ76733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ59"/>
    <dbReference type="STRING" id="72359.L7JZ59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0271"/>
    <dbReference type="HOGENOM" id="CLU_000487_3_1_1"/>
    <dbReference type="InParanoid" id="L7JZ59"/>
    <dbReference type="OMA" id="GIMHERT"/>
    <dbReference type="OrthoDB" id="2194727at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF32">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="6">
        <location>
            <begin position="28"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="355" mass="40143" checksum="18C341E0C2FA30FF" modified="2013-03-06" version="1">MYPPADKYFVYFRRPMKKIVNELEGLATKIESINFGILTEQRAKELSVLKISKREIYDINTEKPMVGGVLDPKLGLSSPGELCETCNKTLQECAGHFGHIELTLPVFHPGYQKMLVKILQTICKKCSRILLPEKKIFLYRINNKNIFNDDTLFGEAKKNQTCFYCSYTNGAVKKGIGTKILYSGYDLNPVVVRSLLSQIEDYDLLNFNKKGCNELYDNICDTGRVDHSFNDTSLQPHLRNDFNLFTNIVVSTVLVPPACSRPSVKTDEFGSNEDDLTIKLSEMVQLSGTIVNSLTTSSLTLLLNDWELLNNTFNSYISGNNLRSLLTRLKGKQGRFRNNLSGKRSDYTARTVISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ86</accession>
    <name>L7JZ86_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0354"/>
    <dbReference type="HOGENOM" id="CLU_604381_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ86"/>
    <dbReference type="OMA" id="INECYVD"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979159" evidence="2">
        <location>
            <begin position="33"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="427" mass="48970" checksum="E06D66F1AD41CC42" modified="2013-03-06" version="1" fragment="single">VKAMLVKSMSKLLSTFLFTSWILPLCLHWSTAGCMMQIVEAAADSDSSGDEAASFTANIIQTQQGSDDTNLTISDNEEGTMSITATSEDRPIDLISNENDFVEKYRPILANFLVQGEECLRDLTVQLKEVKTFKQAKKISQEICEQLLKEEQESTEEGKQNVKCERLKRKIIKFIFLLSREGSNLQNMTISFFEQIMSDFSDVKGLWVYIEECYVIDSSLTSKLNVFDRQSEGYSKILEALEIARSLNLMRVNIIDGKNLTSELLTKFFSTMRDYVTCLNSKISNIQNDHFARYVRDGHVNDRTESLEDRLNYELSRSHYRGSLKVEKTTKDTLPKRTELRPTKEGVKGFWNPESKEKKSYSSYKSAVQSKKLNPELIKRIEKKSNITNSMSTRPGVDTRVKQRQRCSEINFDSRNSNQQPPMVMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ98</accession>
    <name>L7JZ98_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993821">
        <property type="protein sequence ID" value="ELQ76739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0265"/>
    <dbReference type="HOGENOM" id="CLU_1623010_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ98"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="164" mass="19547" checksum="E755CAFEB04CC290" modified="2013-03-06" version="1" fragment="single">VAKQENVLKSVNLYNNTHSNLMLISCYVNSLFCFMDFLLNMEENPERWSNETMTNTNQFHAYFYELVFRHHEAFSHNKLCPFDEDSLEKLDHTLKQFEHEYEAEKEHWLMRRVSFGESNLAITKNFSIVQANSTNLLNNPDKHEEQVESNCLFNPMTIMKQKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZA3</accession>
    <name>L7JZA3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZA3"/>
    <dbReference type="STRING" id="72359.L7JZA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0689"/>
    <dbReference type="HOGENOM" id="CLU_031243_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZA3"/>
    <dbReference type="OMA" id="WRAVITI"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="415" mass="47077" checksum="E40165EBEBD2CB19" modified="2013-03-06" version="1">MGKEDLRKIALELVRDGKGILAIDESSDSMGKKFENFNISNTAENRRRFRNVLIEAEGIEEYISGVILHMETFDQRNDKNILFVESLSSRGIIPGIKLDQGLGKIEYDDVKIKATKKAKEVEENVPENVKSSVKNAGDKVVGFMKQHSEYAKNKIEEHERPLTEEEKVKEAKKYGEFIKRSSADNAEETYHEQVTRGLEDLEKTLASKKYEKAKFAKWRSVFKITKRTPTFEAIDKNCDILAQYAKLCQLHDLVPIVEPEVLFEGNFTIEEHYRVLKYVLSLLSNKLNYHDVDLDSVLFKIGFVTSGKNKASVDKESTTRLTSEAILSTIPIKVPGIVFLSGGHTCEDAIDYLRMICGLDAEINLTFSYGRALTSNAMKKWNGNDNNVEDARKVFLQDCQVSSKASKQRNLVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZC1</accession>
    <name>L7JZC1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0208"/>
    <dbReference type="HOGENOM" id="CLU_3144007_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZC1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5622" checksum="6F2F7D34A4DD08E0" modified="2013-03-06" version="1">MVENLDTETVTSEKVNFGTSGPVKNMELLELKREIEGVRNEKEKIIFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZH7</accession>
    <name>L7JZH7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0426"/>
    <dbReference type="HOGENOM" id="CLU_2147619_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZH7"/>
    <dbReference type="OMA" id="MCIDISI"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="112" mass="13182" checksum="E88742E903F9684C" modified="2013-03-06" version="1">MYVYRLAGYGAIAPIYGIKCLFYRKEERETAWHLLWRCERRAEYRTRFLGWMRGCQKLNTCENPREKKFLRILLGGGSHASYNLRVKITAAVATYLSVVVRVRAKLLRKAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZR7</accession>
    <name>L7JZR7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0073"/>
    <dbReference type="HOGENOM" id="CLU_1760067_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZR7"/>
    <dbReference type="OrthoDB" id="2189698at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="16650" checksum="10FC0DE654C36271" modified="2013-03-06" version="1">MSTNLIVIGHTDKNRYATTDTIVFFTRVSNNAYGIKGVKLRLYCHLALKAKSNVVNKIKLVASSDKSAVEHNECRTMIKIPSNAAPTVYEKYLCVYYTLSAVVHISRTSPIVIERRVFIYREPRRAEPFCAIGAFKGITFPSVFVSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZW7</accession>
    <name>L7JZW7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZW7"/>
    <dbReference type="FunCoup" id="L7JZW7">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0011"/>
    <dbReference type="HOGENOM" id="CLU_049131_3_2_1"/>
    <dbReference type="InParanoid" id="L7JZW7"/>
    <dbReference type="OMA" id="YWHQFDA"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="9">
        <location>
            <begin position="41"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="228" mass="26386" checksum="C0E473EED7CBAC1A" modified="2013-03-06" version="1">MINYFNTLLTIKLELQECIHVYLKICSYQAHMNEKRKFIVIEGIDRSGKSTLCQGLVQKLKNSAVNSNPVLINYPDRTTAIGKLVNLYLKKELTFNKETSHLLFSANRWEKNEEVKRLLQDHIVICDRYFYSGIAYSIALGTDEKWAHEPDKGLVEPDILVFLDVPPYRTSTRKDFGDEIYDNLDIQEKIYLQLKKCCTESKNCVVVNGQKGIDEIIDEVYGLIKRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K097</accession>
    <name>L7K097_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K097"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0205"/>
    <dbReference type="HOGENOM" id="CLU_3144006_0_0_1"/>
    <dbReference type="InParanoid" id="L7K097"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5948" checksum="502CFB9847EEA1C7" modified="2013-03-06" version="1">MYDLDGLCFVKMISYSKFIELPPCFRIVRLFEKRLLRLRNMLSALKEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0G0</accession>
    <name>L7K0G0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase III subunit C11</fullName>
            <ecNumber evidence="6">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="6"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0G0"/>
    <dbReference type="FunCoup" id="L7K0G0">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0G0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0386"/>
    <dbReference type="HOGENOM" id="CLU_2984811_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0G0"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="6955" checksum="1619CD64A9C626F2" modified="2013-03-06" version="1" fragment="single">VFDKQIKERIVWKEDVMRSMAKCEKICEKCGYNTASFYEMQTRSADEPMTIFYQCLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MV55</accession>
    <name>Q8MV55_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial-like Hsp70</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily</fullName>
            <ecNumber evidence="6">3.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3057</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="418" first="865" last="869">
            <title>A mitochondrial remnant in the microsporidian Trachipleistophora hominis.</title>
            <authorList>
                <person name="Williams B.A."/>
                <person name="Hirt R.P."/>
                <person name="Lucocq J.M."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="12192407"/>
            <dbReference type="DOI" id="10.1038/nature00949"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.3" evidence="6"/>
    <dbReference type="EMBL" id="AF492453">
        <property type="protein sequence ID" value="AAM97590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MV55"/>
    <dbReference type="FunCoup" id="Q8MV55">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="72359.Q8MV55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3057"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="Q8MV55"/>
    <dbReference type="OMA" id="KHIRMPF"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAM97590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="543" mass="60035" checksum="114C358309FB6529" modified="2002-10-01" version="1">MSKPAIVGIDLGTTNSCISIMQDNVATIIENQEGQRTTPSVINISGENVIVGKPAQRKLLTDPEHTIFNVKRLIGRKYADVKEYTKRLPFSVIDDNGELKIKVDDKRYEPAKLSSFVLSKLRSAAESFLSRPVKFAVITVPAYFNHTQREETKKAGELAGLKVLRVLNEPTSAALNHAITGHIAVYDLGGGTFDISILEKSDNIFEVKATAGDSFLGGDDIDNTLTDFLMERLKNGREMSDIDLAKIRPRIKKAAESAKKELSTQETVTIDIPYAYKDTHFTYELKRAEFEDVVAPLIKRTVKPCLKALKDANIDQVDHLVLVGGMTRMPLVRKLSEEIFNRKPLFTASPDESVAQGAAIQAAILSGDVNKLLLDVTSLSLGIETVGGLMSTIVKRNSTLPLKKSSVFTTSEDNQEEVIVNIYQGESENVKDNCFLGKIILKDIKKAPKGVPRIEVGFEADVNGIYRVTAKDLLTGREQSAEVTGIQTKEKDVAEKMQDKVDEKDEMVDKNDANKSNRFFDLIQSLLSKNSQEVVGDKNEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR24</accession>
    <name>L7JR24_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3206"/>
    <dbReference type="HOGENOM" id="CLU_601563_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR24"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="455" mass="53022" checksum="F71C4D9CE9AACACE" modified="2013-03-06" version="1">MEGTGHDVLVGMQNIRNYVVSISEKELTEILLKKNIKGHFITNSIKIARNCNYDIVVPLLKLIEEVEDKRAILEYALDYYSTRRRVLQGSKMVSVLISSKAYIDDVLRSKLHDFLGKLTNKRSYNCAIEKLYENGLLDHVEVDMLDRTSRFVLDENIKDLDIANECLSVYQKGRKQQICNGYVIKDWERTAKNFWCTVLDTMDEIPSAMLTGAHLVHLFAVPEKYHCRILPLLARAINEDNCYEIARVVIDRDINHVEVLTLVYNYVKSRDLFNDQFYVSDEELDIILREHKDIKAVSMILQLVNNQVIEHIPFILPFLIQEKEFLCLERLVKRYKNIMITYLQQFIEMGMNVKVFLYFDAGSTVQKMIQMAAYDTLTDYIAVLPYIDQNTCQEILRTGNAGLIQPMILKIAQSKKECTEVHDLLKDERDESVREFIKKNAIESKVLRNVVKEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR48</accession>
    <name>L7JR48_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Projectin/twitchin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3144"/>
    <dbReference type="HOGENOM" id="CLU_1769488_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR48"/>
    <dbReference type="OMA" id="MDWYADG"/>
    <dbReference type="OrthoDB" id="2190452at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="172" mass="19785" checksum="15102A363C692EFC" modified="2013-03-06" version="1">MHHTLKMNGVLLKMLIVPLMSTGLTIRTLLSKGVLKGSYDDETISNINKELRSMNYQAIQNCTKTLLVLKDLDPPAFDNSLILNNLENYIVNREQLESSTLDWLTSMDWYADGEFTDVFLIQNEEYLLEKFSEIFHKCKFCGLVVKGTDKHTYCLSLYKKHLGNASLRDELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRD9</accession>
    <name>L7JRD9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3220"/>
    <dbReference type="HOGENOM" id="CLU_590791_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRD9"/>
    <dbReference type="OMA" id="CACELYL"/>
    <dbReference type="OrthoDB" id="10465431at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="472" mass="55595" checksum="764C232ED36F45B9" modified="2013-03-06" version="1">MFANIFFNIKLFYNLLFDNELMEVINNTNRIFYFNLDNTIEHGRSGIEYRNAMLAVSMDLQARFNKLKVVIDEYEIYQMFLRICENAPEDSCYNSEYLKMYEDDAMNALSEICKTKARIGYQQVIKLVNGRSQRVTCFDSRSATKILENLFLRIVKNNYDNYLQLMGYTSKYECICRSNNNKITKTVELLVKTLKGRFFSSNCTNLFCHNLAYLSRSAVQKFTKANNKNNETKTCKYIVKKLTRKSSKKEGFIELDKCCNPQCAGVMSKHLKQVVYFTIDRNYKAFEQPAQLVTELNEYALFNYSPNNIMIIHINLYSLIIQEFILQNSMPANPWNDFNFSEISNSTTYTNKSRIMNNVILFIEKLIKCHYQNNYFIIVLKKFCAPEQDTSKRINIAGRNHTIDQLKNIYKLLKQKIKDLCCSKLLRKNVFLFKEADFNYETILENIRTNRRVFGNNKYKDACACELYLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRH5</accession>
    <name>L7JRH5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Reverse transcriptase, LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRH5"/>
    <dbReference type="STRING" id="72359.L7JRH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3025"/>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="InParanoid" id="L7JRH5"/>
    <dbReference type="OMA" id="PIKCALE"/>
    <dbReference type="OrthoDB" id="5152741at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="147" mass="17234" checksum="2D2D8620D26A47F9" modified="2013-03-06" version="1">MVIGFKNAPMIFQRVINQVLDRLIGNGVEVYMNGIIIHFKKCDALVREVIKRLSMNKLNVNIKKVQYTRQEVKLLGVTINERDKMPNKMKKNEALEFPKPYNIMQMRRYLGLVGWFREFVQNFSVIAAPLYNALKQKGALIWNEDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRM1</accession>
    <name>L7JRM1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_3031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRM1"/>
    <dbReference type="STRING" id="72359.L7JRM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3031"/>
    <dbReference type="HOGENOM" id="CLU_339243_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRM1"/>
    <dbReference type="OMA" id="YAHDSWI"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="838" mass="92089" checksum="28F0217160B6ACF4" modified="2013-03-06" version="1">MPSQNIEVHIKIRSSPSPYLHTAPPTLSINAHTFTFTHIHTQPDISSHLQPTIQSFLAGNNTSIICYGQTGSGKTYTMGLTASHIETCTGIVPASMRMLIERVSVYLAVFEIYNEEVYDLLDGRARIVLRNCGAELVINAHEREICTYEQFGEVVVGAIARRVTKSTRMNAGSSRSHAVIRVRTACATLVFIDLAGSERTKRTGVSNDTMREAISINTGLLALGNVINALYNRKRFVPYRDSKLTRILKPILDGNTVVRMIACVSDRYQDANETMNTLEYANRAGCLRTAVRREPVIGKEQGEVMRLQEEIGRLRRENEWLRRELKEKTGREPCRCIATQRLPTTARIVNDGGNDCVEIDGNDRGSANDRGDGRDKVSIDNPINPILNPTTNPVSTTNPVSTVTTTNTNPSTNTPIRNKVINTVPTPVRREGTRDVQVPTPIRKINFDLSRNLTLDVGHRKVRRIIDEVGIGEVGIDDSNDKEAETLNTTSAINSTKTNALNTINATTTSRATTTRATTNITTNKSRIEQPIQPLEQKTGIVNKPSRKNKNSPQETTTPSKRMRTLNGLKHVHSLAVHSSTILSIMHLNGAVYTTSSDNTLRRTAADRTVILKRCLFLSLLACNEHGNVLYTTHDALYAVDGALIVRYDTAITGVHYKDTLVVTGHVDGRVRVCDVRMGVLYENTWHRGCVNAVGVYDGVLYTGCVDGTVCYAEMAGGTVQGTCACLSPAHNNCVNLIFMHKGYVFSGSKEGTIRKWKDCRLVKECSTMHSSFMRAGAADAHSFYTGCKDGVVKRWNDEIVEGGSVRLPCSVVCMDGTGDGVVVGGSDGNVYFVGCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRP0</accession>
    <name>L7JRP0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protease, Ulp1 family</fullName>
            <ecNumber evidence="6">3.4.22.68</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.68" evidence="6"/>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRP0"/>
    <dbReference type="STRING" id="72359.L7JRP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3156"/>
    <dbReference type="HOGENOM" id="CLU_024324_2_2_1"/>
    <dbReference type="InParanoid" id="L7JRP0"/>
    <dbReference type="OMA" id="DRAANSQ"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ73960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="224" mass="27146" checksum="3CA1D5C9A8044204" modified="2013-03-06" version="1">MRDPLFTNKTKLVAYIRKNINNCVVKDHMDVCTEEYCILLTNQWFNDKIINFYFNLIKIYATIFEIKVYVFSTYFYTSLKTKGIKWVQKYTKDENIFLNDYIFIPVHRNNHWVFVNVDVNNDEIEYYDSLFSEYRIVSDIIDYLESERAAKNLKPVKYTMVERNYPKQHNGYDCGLFICMYARNRIFGTHMSFKNKNMYEYRLRLAHELLEGEIIYSLGHQFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRQ9</accession>
    <name>L7JRQ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRQ9"/>
    <dbReference type="STRING" id="72359.L7JRQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3125"/>
    <dbReference type="HOGENOM" id="CLU_568129_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRQ9"/>
    <dbReference type="OMA" id="AMRNDPF"/>
    <dbReference type="OrthoDB" id="2190778at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="481" mass="57042" checksum="63107A84CA397303" modified="2013-03-06" version="1" fragment="single">VVLKSEPLMKLHTKDNGLFELDALPDDMALLKDFITEYQLTTSSQQKLALLYYENNEFENCLELLKFCVSQNLFSSNDLQKLNLTLLAFYIEQGRGGKYLDECTKLFLQLENTKYKDELNFIKGYFFLYKEKYDTALFLLSNDVLGRNLIHLSMKCPEKVESSDPLLQGYKAYLENDEETAVKYFKQEYQKNKKVLPYLLRLAPNEFSYKDSDEWTKETPEYRLSAKEQDNVYTEQELLDTFGDVIKDEFLYQRARQLHLKEQYEEALECYIQCCGRRAADYQVRRILGLPFEDNKELGDLYQLKKKNKEIGNPVEGFINLKNNRKYLDDATYYCNRGYYVYFIDYYTEQIKKEIKDDLEIEDFSEAALCYFRKALEKADLEQEKGIAYNIQMLEKEKEYEYVERDLEDAIENVKNDPDRSLATFIKYVERENNVVAARGIGVVLAMRNDPFCIKIFKYLHDDHNLKIFLENQINKENNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRV0</accession>
    <name>L7JRV0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRV0"/>
    <dbReference type="STRING" id="72359.L7JRV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2916"/>
    <dbReference type="HOGENOM" id="CLU_055474_1_0_1"/>
    <dbReference type="InParanoid" id="L7JRV0"/>
    <dbReference type="OMA" id="KMPRPVF"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="387" mass="45163" checksum="BE4F7C519BC7E1B0" modified="2013-03-06" version="1">MQKSDTKQRKRVPGISEHLKAIREINDRINAITASVKECKDKIAQLIKEEKSNSPKVQLIAQKQQLNDDLSAVMEERDKLMEEKKALLPEYLKLKEDLAAEKRKINLKENVLELDNKIKEINDNIMKCTLTTQQEKEYANRLMDLKKKKTFCATLKGKELRIKTMGDELHVIKDKLAHNANAAHKIKLSINDVRNELNRLRETKIKNPRIEENDAKISNLKKEKDELLEKRRKVQLQIQEKEKEHERLMQEMEKQQEIENQKKEIVKEMREKEGRKNLLLKEIVEIDPHKFDILANELKNVQSNALPLSLVKSLAELKLPIPKDSEDINALLNTIKDRKKEYESSIVGKVEDINKKIKDIDVELVKCKEELSKMPAVEVGIRRMRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRY7</accession>
    <name>L7JRY7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3017"/>
    <dbReference type="HOGENOM" id="CLU_3224898_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRY7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5408" checksum="F7E49DF260E02CC8" modified="2013-03-06" version="1">MQQLKKTSTMDEKYETWLEKKDQLLTRIEGGRRNECFVMEKDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS09</accession>
    <name>L7JS09_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Pleckstrin like-type, Oxysterol-binding protein, Pleckstrin like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS09"/>
    <dbReference type="STRING" id="72359.L7JS09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3271"/>
    <dbReference type="HOGENOM" id="CLU_432916_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS09"/>
    <dbReference type="OMA" id="INRYQTR"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF148">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ73831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="632" mass="73020" checksum="E008912F34FD6019" modified="2013-03-06" version="1">MDHVVIALRILNDDISFMMKLVKEKYVSPIFGTVGEHLVYLRRIDLLKSLCASLEDEKVTEEENMNAYLLKRESDDCIVEKNSAINEFIASFLPLSKKLNYPEITLYFDSSSIRSPVRAGLLQKYTNIINRYQTRYVTLYDDFFSYYKIREGKKFLRKKLSLNTIRGIKLSRRRLIISTYDDKIVFTSTLQDLMEWYKVIDDLIKRMNDREFYVNNYVFKLLYYLCEKEARKEMLKIDHLSLYIKDKGVQAVASESNAAQPPVTVPQVYEAAKTNEVQVSSPSESPQLEEFESATENNSSETFYDFEENGELTNVAHLVDSLVKSAKRLAPALLPVSLLEPQSTLQRMAEGALLFKNIRRNDSLSEQHAVVLVAVYIVGLMNLQLDRKFAFESLAGETFFAEHENTKIYCEKTLRASIVHAVDDLFTLTAVIDLAYDKRNKKIVVYNKSKCTLKISDKTINFGLPNVRIRRKLEFCGECMVESEGEQAKLLVRDNNVTFSYRNGDKRWQIVGPVTNITVFCNERITANFSSNDFKKMKIEDYEDVHEYMPSDSRGRADIQALQEGRVQDVNVHRQKMKDQTKLKGSPEMKYFDLIDKKYVLKKGDGGRKDDDEREDDDDDGGRKDDDGKMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS53</accession>
    <name>L7JS53_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994049">
        <property type="protein sequence ID" value="ELQ74303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2780"/>
    <dbReference type="HOGENOM" id="CLU_164198_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS53"/>
    <dbReference type="OMA" id="LNDYRYC"/>
    <dbReference type="OrthoDB" id="2188272at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="Zn_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon 15" evidence="1">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="106" mass="12063" checksum="E03AB918605F9850" modified="2013-03-06" version="1">MSHMCQCLICGVMTKIKSKKNENAVEDVYCPFCSNNVDAADIIHKYYFTFFFIPLFPVGSSTKYVGCEVCKGKFSDGRVRICHKCRNIILNDYRYCGRCGDAVGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS78</accession>
    <name>L7JS78_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994070">
        <property type="protein sequence ID" value="ELQ74140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2946"/>
    <dbReference type="HOGENOM" id="CLU_3126087_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS78"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="5760" checksum="CAA03D28754F55E5" modified="2013-03-06" version="1">MNEKNRLGEFHLVNLPDCPDTYSRNNSRDMCDGSEVIVQKTKKQVTSETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSG4</accession>
    <name>L7JSG4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994058">
        <property type="protein sequence ID" value="ELQ74225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2854"/>
    <dbReference type="HOGENOM" id="CLU_142432_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSG4"/>
    <dbReference type="OrthoDB" id="2194784at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="14143" checksum="B6F39280E66D8409" modified="2013-03-06" version="1" fragment="single">VIRTVREAIVKMGVNEMGKAVKEVEDKYNKTYHAGIKCTPEEAWKDGRYNKQFKKRKREKFAEGQQVIVAQKENLRDKDKIGGFWEKNEIIAVYKSDSYLIRKSDGRTLKKRHYDLKVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSG6</accession>
    <name>L7JSG6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2737"/>
    <dbReference type="HOGENOM" id="CLU_1129754_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSG6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978684" evidence="1">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="246" mass="26619" checksum="A4E18DBC983A641E" modified="2013-03-06" version="1">MILYIILLLATSPEQVKDHSIVKLQRRCMTAQDEGNVSNPLVTNNNVYSPKTCEDQGVHGEILHNNLSEDGDVQLTSVMNGMSLAEKSLSKEDGESAPCDLTTPKKTENKQLGIRTSTKKSKSLGCISKIDPVCKNMCDNISSNGAMSSLDTASTSRSYMNEKNRYSQANPVNEICYDSDVDSIDTSGVFSNDGATNEDGWDEIARKLDAIFSDPETLSLILENGFIDAHGNPSGAEDAGPSRETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSP6</accession>
    <name>L7JSP6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Armadillo-like helical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSP6"/>
    <dbReference type="STRING" id="72359.L7JSP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2633"/>
    <dbReference type="HOGENOM" id="CLU_443846_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSP6"/>
    <dbReference type="OMA" id="ALWHINS"/>
    <dbReference type="OrthoDB" id="2191742at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="616" mass="72906" checksum="2F55F61EC3F08EDC" modified="2013-03-06" version="1" fragment="single">VIIGDAGDVSTNIDEDFILKNSLEYLSQVFKQHPDLYFKCWNNIKQNNDQAKFEKLSNLALLSKIDENQVFEHTTSPSERIRYIATFVTIRIFMYRMKTNHDFDIDIVLNRLRDVYHPIRVVVVREIFSFYEKFGTLVIDKLLLALHDSKDEVRVEVLRTLRRLYNKYKMEIGFVDIIKRLASDGISSSTRSEAADFLYDVFSAEDKEDDLFGVLVNCHPNKIKNVIMKIKKEKKDIYEVYHFLYNKSGMEIFRNIEIRKKGLDAYLDHVIDRISRSEQCCRKGNCHLHVLSTYRHTNLEKIYTLLSIVKDSRADIEIILKVLERIKNDVYVNSTYTTQILDKLYEYGQIYRLNYFSLLKRLETDYQPYVNEIVKRIEHEDLIKYFNVEPFNNAGVIYKALWHINSDQYDKVKTLVFSDRNDDNFDELTELIFFLRSKIDDLSKSTNAEDVQDMKDAFEFIYMQSITYLSTKIDQFKRDDNFYYNLTKFICNGNFKDKAGVIFRSAKHYRSLMVKCKDLGLLIELFTHFLGYEKGIRTKYLEKMTKTFKLRLKNYPSTEIFLILRGFQNEGASMDNFIPLIDMLSLDECIILENTAVGRFKEKLKEKCVERSNAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSS8</accession>
    <name>L7JSS8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2445"/>
    <dbReference type="HOGENOM" id="CLU_1005389_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSS8"/>
    <dbReference type="OMA" id="DEKCYLY"/>
    <dbReference type="OrthoDB" id="10387184at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="277" mass="32707" checksum="EB72AA8BD398A775" modified="2013-03-06" version="1">MFFLVKFSCPMTESRSARGGNVAIQMHRKDQTNVDTPSEKVKSITEQQVKKVIAYFDTKKIRNKRFKKCIRYLKRLPSDIDENLDVIFVKIFKLHLSDDEKCYLYSNMVDLIFLMDEPMLIADKVHNDASSKQKYSFLACKCLFILIAEYNFCCLNFFNVFMEYIDQQITENTEDTCEFIIQIVNRICLSFADVTRLVTAMKQYLLSLSSSKTYALLNAIRFIVEKHVLLHERFVKGDKFWELDVLEHSIEPIKCLAQAIKYKKERKYRLNRDEQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSU8</accession>
    <name>L7JSU8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994074">
        <property type="protein sequence ID" value="ELQ74116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2968"/>
    <dbReference type="HOGENOM" id="CLU_3175708_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSU8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="47" mass="5697" checksum="2EE8401D9614D9B9" modified="2013-03-06" version="1">MNEQLKNNTRGSLKKENFENLRRENKKRTKGSYKIGDLVYRRNIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSV6</accession>
    <name>L7JSV6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Nucleic acid-binding, OB-fold, Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSV6"/>
    <dbReference type="STRING" id="72359.L7JSV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3262"/>
    <dbReference type="HOGENOM" id="CLU_150840_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSV6"/>
    <dbReference type="OMA" id="PQQICEF"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="16858" checksum="E95D7655F87A8960" modified="2013-03-06" version="1">MFFFTDKLLKSPIHFIMGAKKRYKGTIKFFSYERGYGFLVPHDPEINEDGKLLFLISVFFHFSSISTQPGMVVYLLPQQICEFELVKGPRGYLAKNVTSEHKMETRGQKTNDIYYHYYHSFRKIMSKMIEDEIDKMKENKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSX2</accession>
    <name>L7JSX2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2703"/>
    <dbReference type="HOGENOM" id="CLU_2392083_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSX2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="94" mass="10626" checksum="8B18A8AC3C5D9085" modified="2013-03-06" version="1" fragment="single">VICVFLRNDRKVVEDVKEFSDGFFNVSHDENVLENLTSESEQSCSTSNEINNSTVSFILCKISKTENGSKNNNTTGLNNGDLYMSFEEKNEKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSY6</accession>
    <name>L7JSY6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_3232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSY6"/>
    <dbReference type="FunCoup" id="L7JSY6">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3232"/>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="InParanoid" id="L7JSY6"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="37"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ73857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="314" mass="36947" checksum="495D87235CECE4AA" modified="2013-03-06" version="1">MVIPTVSKVHANFCQEQPPEYYSYEEYEPEIGNIDNYKIIKRLGRGKYSEVFKGICTLTKSFIAIKVLKPVRQKKINREVLVLKQLDHPNIVRMVDVVKDSDTHTYSIIFEYLEHRETRVLFTELSRKEFAFYAKQVLSALDYAHSRGIIHRDIKPHNMIICKDSRTLKIIDWGLAEFYLPGTAYNVKVASRFYKGPELLVDYNYYDYSLDMWSFGCIVAEYFTKKSPFFFGKDNIDQLFVITEVLGRDDFYAYVKKYQISLEEGIVVSKNTKRKKFNVDIGECVIDLLDKLLVYDHCERLSAKECLEHNFFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT17</accession>
    <name>L7JT17_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2935"/>
    <dbReference type="HOGENOM" id="CLU_839881_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT17"/>
    <dbReference type="OMA" id="HRPRAYY"/>
    <dbReference type="OrthoDB" id="10579762at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="331" mass="38504" checksum="89AB3917A8F666CE" modified="2013-03-06" version="1">MQNQKKRNRMSLQFFQIFLFICYNAFAYNLTQERVTHVTFCIIKDDTNDKTGQNEPKKTDEKEPYDETIKMAKKKLQTSAENLLKTLTELNMHTYQVGTRIYKLFSSEFEGHCQAYYSELDSYNIMNSIFKPTRTDAVAVAKRLENAIISVCDEKLYNIVTTDQHETFCYPTPSCSSVKGFEFNKKRLSEEFESEVIFVRTFATILFVSGIIDKNAYSELLLEILGTLKKQLNDLLYQISRDPLPDYHIRVSEKVFDSWYITFCWKREASKKLGDLYNVRDNELKAFVRKIVLKGATDVDLLSMLNVQISINKNKVDSILKELVKGDCVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT55</accession>
    <name>L7JT55_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2884"/>
    <dbReference type="HOGENOM" id="CLU_1387258_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT55"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="22284" checksum="B16630BD33EE9448" modified="2013-03-06" version="1" fragment="single">VTEENNIRQSSKSIVESRNTSQQANDGTHESKNDLTESVQHSEMRKPSEMNTTDFTSVKDTRSDKLENSTQMTMQNGEPGRPTQQDDTMKPPIRAESTESPKDQKRKSKAKEDTPKPLSTLSLVPYSETNLRSFSQNIGTNEKQEKALSETLDRSNFSKSDLIKETLPTLYYPPTCLTQKTTIVDRIKSIKKADVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT61</accession>
    <name>L7JT61_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2605"/>
    <dbReference type="HOGENOM" id="CLU_1397220_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT61"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="195" mass="22568" checksum="410AB53A115E468F" modified="2013-03-06" version="1">MNLNSLQSTVLASVFVIVFNPKYEEKVIGENDYLVVDDTTDIWFKPEDLFIYGEWNGNKSVEQICYNIFGSEIAVKPKSESRGDNMNDNGKDSTNKTDVDLRNNVAAYKYQTITLPISKALYEKISNLSFISDTKFTFGEICDLLTMSPRLFDKEALIMFNVFKNLVNDRNLFLKLNQFFRKISVCKKRHIYSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT62</accession>
    <name>L7JT62_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="10">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_3143</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="10"/>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT62"/>
    <dbReference type="FunCoup" id="L7JT62">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3143"/>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_1"/>
    <dbReference type="InParanoid" id="L7JT62"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="13">
        <location>
            <begin position="125"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="14">
        <location>
            <begin position="266"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ73947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="409" mass="45379" checksum="45C045CDB5A9546C" modified="2013-03-06" version="1">MSNYPKFLYTSESVGKGHPDKLCDQIADRILDAYLSKDSLAKVAVECIVTQNMACVFGEVNSTAKVNTKACVVDVIREAGYDDASTGMDYRSVLVIENISAQSDDIRSAVEKTELNGKMLDSYDKIGAGDQGIMFGYATNETPERMPLTLMLANRIVEEIENLRKTYEFIKSDCKSQVTVEYENRDNELVPLRIDNVVLSVQHAADLEKWTNVMNECVYGTSDQPSSLKPLELFRAFLRKKIREVLPEELLKSTKYHILPSGKFIIGGPKGDSGLTGRKTIVDTYGGFGLHGGGSFSGKDWTKVDRSGAYAARWIAKSLVDSNICKRALVQISYAIGIVSPVSCYVDTYGTGVIDNDKIIKIINENFDLRPKAICAALGLDKPVYGRLSVYGHFGRKGYKWEESKNLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT70</accession>
    <name>L7JT70_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TATA binding protein associated factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2539"/>
    <dbReference type="HOGENOM" id="CLU_252130_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT70"/>
    <dbReference type="OMA" id="LMAMHYL"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="1361"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="675"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1114"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1437" mass="163220" checksum="FA1D3CA04E1399D5" modified="2013-03-06" version="1" fragment="single">VMELHHQTIYLFIDPNLRKAYGYTECTTEGVCELTFKVGKLKIQSVHVNDDPVQYKIKTDAHIIDENERTIGQGLYAKLIDHRNTLSVRTAHAMNTVRVQFVPNVQFYERLPGDHKHAEVIGVNGECVLFPYLDGMAEYTLVYVVPPDFTVVSPGQLVGVIEHCECIVHTYAVRTFAENVCFAVGTYEAYEISAVKTLYMPRYAAYADLKNDLNAAHRFVNAFVGGEHALPLSLVFTMVPCTAVALHVALQPLSTFPSADDIALNFAFKERVACLIGTQLFINTYFEREDLWLRQGLIGYIADHILKHMLGTNEFLFRLRNAIDAIVRVDHLHLPLYAPARSAYSYRSAFVRKKAAVFMHILENNTSLAFMQKIVKICLSAQRINTHAFIGTVRDVTGKDLRSERMIYRNNSGTYTGELSIDLKKNQVHVIFNGPVNTVVQSHEVEGVYEHVVKRELTYTYHNRRKKDDESVLFVRVDPYITQLSTYKLVLKGTMYVNMTRDKNVLSQMEGIRHVDEGELERLVYDVHTNYRVKLMAMHYLGINSILSFFVKKFCVQGSTIIRPNAFSVLNHEVLVGTMRVLSQFDPYVKRVVNEKVVSVGAILKAFFYNVLRYNDNSSNAYDDSVFVGQLIRGLSFMLTVRSNDREVEAEAREGGVGAVEGVVVGTGEGAIRDEAVEGIDRVKDNDDNRRDNDDNREDNDDNRKDNDNLNNDKQNTIVNSRTDDLRNNTDDNGRDNGRDNGRDNGKDNGKDNGKDNDKDNGKDNGKDNDKDINPTNNINTTLNTNIPNTTLNECDDIYVEIIERYRMKDIIFPSNCNRVTCAVLYFYGRLDLYGMLSMNTQYLLTLIRPANFIAVRCAAAEILTFKTILDDDHASTRHSTYVLLDTMLRMEDAIQTTVYKTISNLLTCTTYNALVKRRLCKSYFYDRLRCTESASLREHVLDVIYFLEGLDVEIRADEQLEHELSSTDEESVKVRVVPLVDLRVRLRVNGAYDGVFVRRIVPVRENDGVVKLRIGLRAGLDVPGKRMRINEGVVDEEGISSDGRGTGVDGRVRGISMGSDRIRRISNEGIDNEGVDTTTNITTESPLNAKASIPLNNKNNKTHGLRGTNRNISRNDKARAKGDRTEKKKKITKNTTRDERMRHTAQANAKITDITRAAEHTRWCFTDNTMIRRIVDKYGDKMPFPTGITTERELRAFLTHVFMSTGTNAPQYSLARSVYNELEHSKLLIPLLNRSYTPLSAAHKQNLKKLLNTLTIPQFTRPKNYKDITRRPKTVYSLKKKLDSIAVLEFFKLEIVDFLEKCTLFTSKRSFNENGLLAYLYALPESKHVSVYELLVQCFELIKTKRVCAEFVGEVKVDGYDAVVRTPMYLDLIVEKIRDGVYGCVLDVQRDVELIAANAALFNGEDSVYAADSKHLVKWFKRIVGGMLGDLYNDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTB7</accession>
    <name>L7JTB7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTB7"/>
    <dbReference type="STRING" id="72359.L7JTB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2385"/>
    <dbReference type="HOGENOM" id="CLU_025402_0_1_1"/>
    <dbReference type="InParanoid" id="L7JTB7"/>
    <dbReference type="OMA" id="YENVGRE"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="8">
        <location>
            <begin position="196"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="326" mass="37139" checksum="99BA8E1B2FE71E83" modified="2013-03-06" version="1" fragment="single">VYSLWLPSMIKDGQPVILYFSPSNIKLIHKDSSTTLNTSAGPLKHTSIDRYNTIIHLKNGQVTILRPTHYLISNTACSTQVIFDYDASFVCFVMGLKSTDVLFEAGFGSGVLTGSLARFVRLVYSCERIVDRIRNVGKNVIVYEGDCNDLIVDVNEKDYLDKDDGNLNEVESLQMNDDDELNKDDQHVVERIDEQNRMHHAHTDVGQDTDGGSEKMVESLHRKNCRISTKNVINKMVDGIVLDMPEPWLVIPTLKAILKRNKTMCVFVISIQQVTKTLRAMRTFKNIRVYENVGREYSMKKSCGRRVCELKDNQYMHTGYLIFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTG5</accession>
    <name>L7JTG5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino Acid/Auxin Permease (AAAP) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTG5"/>
    <dbReference type="FunCoup" id="L7JTG5">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2314"/>
    <dbReference type="HOGENOM" id="CLU_009020_1_2_1"/>
    <dbReference type="InParanoid" id="L7JTG5"/>
    <dbReference type="OMA" id="KARMQNV"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="44"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="426" mass="48849" checksum="C873F691CF9CF6F3" modified="2013-03-06" version="1" fragment="single">VHVSQHSINKLMFTFIRFILKQIGIIIYKHCFTTRIPFLMKEYLSGYVNILKTIIGSGILYIPMLFKSYGAISTFFLMCLSATLSMVGQIIFLYCNAFLNDRSTNITSLARESVPRTRFLVDFFVFFKCFGVSTSYLIIIRELIPNLIQTVFGESVLARPKVALLIFLCFISPITYFRQLKNLKYTSSIGLIAISFILFFSMYNFIKHGSLEHVTLYEPITIEWLKGLGTFVFAFTCHQNLISVQNEVVDNSPDRMKKIVYATTATSLVIYMVFGFTNYALYATNMHDNVLKSYPNDHITLFLHFLYVCVMGFSYPLQINPARVYMYNLLGFNTKKRNNNLVHAVITTLLLASTYVLTITGLNLGEMYAFVGATASTMICLIFPLLFYYNMGLERKRWLIIFGCIGFVFGSCVFALSLFKLLKHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTU0</accession>
    <name>L7JTU0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2239"/>
    <dbReference type="HOGENOM" id="CLU_2392082_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTU0"/>
    <dbReference type="OrthoDB" id="10574057at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="94" mass="11067" checksum="E7060AD6BD8272EE" modified="2013-03-06" version="1" fragment="single">VCKHFAMDVYCEFKSSFNSKMQVVMHTDEECAHTIDRFVTCDAKNLLAKIVKRETEGILFTRDVLRICEEKEFLKDSFQVGRCNEIDYYKLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTW7</accession>
    <name>L7JTW7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">THOM_2306</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTW7"/>
    <dbReference type="FunCoup" id="L7JTW7">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2306"/>
    <dbReference type="HOGENOM" id="CLU_000846_3_1_1"/>
    <dbReference type="InParanoid" id="L7JTW7"/>
    <dbReference type="OMA" id="XVYFIAT"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.70">
        <property type="entry name" value="Designed single chain three-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1125"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1150"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1208"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="21">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="377"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="876"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="878"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="957"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="963"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="983"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="986"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="987"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="987"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ELQ74745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1248" mass="141826" checksum="75EEF6E675FEB86A" modified="2013-03-06" version="1">MKKQEDVVFRTITVSKPIKQAYPRNIIRNQKYSWYSFPFIVLFNQFKHFFNVYFFFISFSQLIKTYRVGPLISNIAPWFFVLFLTLGKEAVDDLQRYVRDKEANSEEYKKVTREGVMVVPSSTLQVGDLIVLEKNQRVPADMVILKTFEDEGQCFIRTDQLDGETDWKLRNAVASTQVQDTAHLFKRSKEMTGLPSVMESLDNVGELNHDVDEIDHNVDEVDHQMNGMDHNVDEIDHNVDEVDHQMNRMDNNVDEDAGIEGKQSNYEIENRKEELVEGIDHGPEEIDRALANNDETEKEVGQGFNEGPGTLENERTSEGDQISIDRPSVERNVEISPTNGNKSSINNKSINTDETSMNRGGFDSSSDEIHEVEVHGTGNAVGKDDQDGDVGNLENNDSLKNRKCNETGNRGEHPRSTVIKIEQGTRRSASHNTLVKADTSELFNSEIVIYADKPHKDIYNFIGRLTMNKDEGTVAEPLNLDNVIWMNTVLATQGVIGCVIYTGKETRAMMNTARPRNKFGKIEEEINYYSILLCVSSVIAACVFLFFSGISSRFDVNLVRFIIIFSSVIPISLKVTIDVARMFFYSSAIMKDPDIPGCIVRNSNIPEELGRITYLLSDKTGTLTRNEMEMRKVHVGTICYTTELNSEITEIIRKKMARKHRRSRDLGSRVFELVRALAVCHNVTPVEEDGKHSYQASSPDEIAIVQWCEAVGVLLEKRTKDNVEIRILEDTVKRYAILHVFPFTSDTKRMGVLLRDEDTDEVLFVLKGADMVMRTIVERNDWLDEEVDNMAREGLRTLVIGMKRLSTEEHEEFEAAFRQANLAINNRNEEVQRVVCSLERNLKLLGLTGVEDKLQENVNQSLENLRNAGVKIWMLTGDKVETAISISISSRLFLKRNRYEVLQVTSREDAWQQLSMVKEKMINYVIIDGSSLQIMIDNFMSEFIKFAATLDAVVCCRCTPTQKALVARNLRMLTSHRVACIGDGGNDVSMITEANVGIGIVGKEGNQASLAADFSILKFSDVTTLFFWHGRNCYKGTAKLIQFIIHRGTIISVMQGIFSAVFLFSPIALYQGFIMVGYVCVYTMCPMWCIILDRDVSKVNCFKYPELYKEMVHTKILSARSFASWNLISFYQGSVIMIATFFMFKHELLSIVSITFSCLVINELLVVLLMVSSINRWMILSQVVSLVAYVLSFIFLRDELRLPPDIKYFMGSIALISLIAIAFSVAERLYFKYLRPPSYSKIQSANFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTZ3</accession>
    <name>L7JTZ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2545"/>
    <dbReference type="HOGENOM" id="CLU_062685_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTZ3"/>
    <dbReference type="OMA" id="ITHNEKE"/>
    <dbReference type="OrthoDB" id="2199193at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="291" mass="32330" checksum="01D2956476C6032E" modified="2013-03-06" version="1" fragment="single">VHLMLLYLSFIFTSEFKLKHATSNLFVGLDGRYPNWVTLERSNTFEEKPSDVEGEKIIEVKELKDKVWDIEGNVKNLIFYPKHGKVNQRFIIAKLTHSNVRIKSANGQCITHNEKEKFFERKECSDELATQIFVMTDANGAPLSSGAVSAAGDEWGNEWGSGWGSGWGSGWGSGWGDEWGMGSGSGWGAGSGAFGDYKSDQKLALDEIGRNARFLDARIMSGGMYGGGKGYGNGYSSGFMNQKLDGMFDTLPAFDKQNLLKLYYQNMGGPRSSRYSRFGRTPNSFSFMHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU00</accession>
    <name>L7JU00_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU00"/>
    <dbReference type="STRING" id="72359.L7JU00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2096"/>
    <dbReference type="HOGENOM" id="CLU_070108_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU00"/>
    <dbReference type="OMA" id="ADIGHET"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="285" mass="32637" checksum="CD932426AE6FCFBE" modified="2013-03-06" version="1">MLLINNFRLPLHMIKNDIFIIDIGTSFYKMGHSLRDCSIFGKTPDDTLVDKEINDYETYLNLIESNLGTEYLIINLGANRRVLSNLFEKRLVQGIMFVDDRVMDLYAAGKNNGIIINVSGSGVECAAICDSLVVESVKIYDGKEIDAWILKDGEDKFVFKETFNYLEESKNTLEEKVKQKVLNDIEKAMNDLINKIKPEMKNSLLANIVLCGGYAKPPSLTEKIYDVLSKEHKNIKVTKELDIFSTYTGCDILSRLDDLDYFIGMKDYEEYGANVLDKFNIEWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU77</accession>
    <name>L7JU77_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU77"/>
    <dbReference type="FunCoup" id="L7JU77">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2013"/>
    <dbReference type="HOGENOM" id="CLU_071681_5_2_1"/>
    <dbReference type="InParanoid" id="L7JU77"/>
    <dbReference type="OMA" id="QGILNQP"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006311">
        <property type="term" value="P:meiotic gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="98" mass="12353" checksum="7802F487ABD48FB1" modified="2013-03-06" version="1">MLTKFEKELEFVQLLCNPYYLQYLYQNKYFDDPDFRKFLKYLEYWKEKPYRNLLIYPQSLAILDALNNNEEFVSKLDDEKILEFVDEQLRFYWLHKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUL5</accession>
    <name>L7JUL5_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2052"/>
    <dbReference type="HOGENOM" id="CLU_146853_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUL5"/>
    <dbReference type="OMA" id="RIMVWGR"/>
    <dbReference type="OrthoDB" id="5950832at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="112" mass="13643" checksum="74348C91C8096ED2" modified="2013-03-06" version="1">MRKKLSLLISELSTILEDSFTLSKYPRPRTKMAFNFLKFADDSIRLFLITVCVRKKNYYIVFDSTIYCYAFYDEFIPMDKRIMVWGRVYGGKWMIIMQWKYIDAKKICYDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUN1</accession>
    <name>L7JUN1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2572"/>
    <dbReference type="HOGENOM" id="CLU_3282354_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUN1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="5007" checksum="71FF2BB473DEEF8A" modified="2013-03-06" version="1" fragment="single">VYESNFTRETRKRLCKIDRQAIERYFINKGDDELEEGEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUR1</accession>
    <name>L7JUR1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA mismatch repair protein MutS, core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993982">
        <property type="protein sequence ID" value="ELQ75193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUR1"/>
    <dbReference type="STRING" id="72359.L7JUR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1865"/>
    <dbReference type="HOGENOM" id="CLU_1745011_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUR1"/>
    <dbReference type="OrthoDB" id="2188923at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="150" mass="17505" checksum="9135BC6D14008F1D" modified="2013-03-06" version="1" fragment="single">MGYQLLKNNILFPFTGSEEIVQRQAAIEHLIDRKLTGKISHSLKNCIDIDANEFIFFKENKSEYFIKMYKMLSSVLVIVDLLRGHGGVYDVPDTLKCYGDICTYKDLIKNIERKINFKEDRFNIRPAVSDELDFLKNQYSDLENRLSEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUX1</accession>
    <name>L7JUX1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaphase-promoting complex (APC), Cdc16 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUX1"/>
    <dbReference type="STRING" id="72359.L7JUX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1764"/>
    <dbReference type="HOGENOM" id="CLU_594506_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUX1"/>
    <dbReference type="OMA" id="LIYYEYY"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="456" mass="53819" checksum="3EEB395081554B76" modified="2013-03-06" version="1" fragment="single">VYYNSKLYLSALTMSDFIIHTHKDGDIDLCSYKLISCLSLFELNYHHRTLKFIENNEEILNYHTIRTIYLKLGNILEPKKINLALLQDKRNEDFTLADCRLDKKSIEYYLEAMVKKYVDRKNLLINAVESDNRNLEALMALKREDLVSTEEFSELISAGPEWLTKLYTYIMNYNEEIIVSPFFMEAYAYENYKREVTAQLFDLGVEMIEDFPKCSVSYLVLGYYYLSKKKHGEAKKCFYEAIKYDKQIGNLWLFLGLAYSGLKECENAISCYKQAKQLMIGSYKPDFYLAYEYHKMYNIEQASFFYLRAFKIKPEPVVIVRYATLLIYYEYYVDALKILAKVGSVNEFQNVYNLLVAYAFLFTGDLDRSEMFLDKCKRDWRYLATKGFIKHLRSEIETAADIYMDALVQHGRSWVIEDLLRLTVEIKDVKKDNLAYEYANDLFDSMDLKSLDFKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUY2</accession>
    <name>L7JUY2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding Cassette (ABC) Superfamily</fullName>
            <ecNumber evidence="11">3.6.3.31</ecNumber>
            <ecNumber evidence="11">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2212"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        <location>
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        </location>
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            <end position="288"/>
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        </location>
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        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    <sequence length="648" mass="73219" checksum="B36671F4FF0D8DA2" modified="2013-03-06" version="1">MTYSIIYRNITVIKKGNVVLENINLGIRKNKLTAIMGLSGAGKTSLLKVLSGYSTNGEILMKRSLDDGRVVEISDGAGVNSGHDRGTYGTSRSAGSTRDKNRLIKANEFFASKYGIDMARDYKEVNDNYMRNISSLVYQSDVLPSWFTINEYLTFLCRLIDEPLSSIDRLLAEFDMSDRKHCLIGEQDGGISGGQRKRLSIIAELLSDPEILFLDEPTTGLDVRNASVMVKSLKNRKKTIVLTIHQPSSNLFFMFDDLIVLHDKRILMQICTEDIFKWLGDNFFKMGRMTNPADYIFTDILNVCRFEDGHFYRISETGRHRVIDCTRKSGENGDIRRVEDSQAMSAQPGGAQNETDSNGESATLVNTGKNDRPSAARRQRSFLHEFLILTVRNFKMLSGNKLLCFARVIQAIVTSVIIGTIYFNVSGADDFVYEKNASGLLYFLVVNMMFTCSFGGVSAFYKDERLAYRETRGKKYGILCYYLSKLLADLPFVFLYPITVFTVVYLLANLSYSLKQIAFFYCTGLALSYLCHTVGLLFGAAFKDHSVTLIMLPTLITPIVTISGLMVNTDSLIEPYKRMQYISPTRYAFNIVIKNHFGKDVRDKMLKGLVDGFFSIEASFVALLVMILFCIVLGYFMLRWKMHRLAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ELQ75343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="34" mass="4017" checksum="370A778A946E64ED" modified="2013-03-06" version="1">MELGRQLLEGKPLDNLSSYYVKFEDLHVYKETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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    <name>L7JV65_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ca2+ sensor (EF-Hand superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="191686at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005509">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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        <location>
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            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="183" mass="20979" checksum="B14DC1AC3E753564" modified="2013-03-06" version="1">MGNKVSPNLLQTAATVKKFSHFNESDIKKWSAEFNANYPSGYMTEKDLQLIFKKLFPFGECNRFTVILFRTINISGTKTIDFNELLIAYSILRKGSIFEKLRWIFRLYDCDSDGVVGKDEMIKVVKAFLDMIGASFDVNVDVGRFISNIFDDLENKSGFLTFDDFKILAGKKAEVLQIFEVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVI2</accession>
    <name>L7JVI2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1985"/>
    <dbReference type="HOGENOM" id="CLU_1217306_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVI2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="228" mass="26061" checksum="AFD1902D6464C61E" modified="2013-03-06" version="1" fragment="single">VKKCVEITSHLLLSSNQNIFKKLDNYQSKNLDVFLTCTSIVVEINYQASRFGFYLTGKDNLRSISIGKAIISVFMEEISTLGSTFRMLEMTHATIIVYNKDLIMNDHKLFTLISRFDFIFSLHVKWNEGKECSRIQAIPFILKNFILNFEYNPNSLTISNFKISFQFFRKLYKMKLKNLSLIGCNVECEMAILVAQEPINLTILMFAFIGGTAACAMKTIICPLIVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVL5</accession>
    <name>L7JVL5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.19" evidence="8"/>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVL5"/>
    <dbReference type="FunCoup" id="L7JVL5">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2254"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="InParanoid" id="L7JVL5"/>
    <dbReference type="OMA" id="GDRAKHD"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="18568" checksum="4FD64181A15233E9" modified="2013-03-06" version="1">MATWESKNSKRRTTNRIQKEYMDMTLDPPENCSAGPISDEEFDKWEATIIGPHGTPYQDGIFILEIYFPPNYPYAPPKLMFKTQIFHCNIKDGHICLDILNTKWSPALTISKVLLSISSLLSDPNPNDPLNKQAAELYMSDRQKYNRIAKDYTRNYAMGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVM9</accession>
    <name>L7JVM9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1523"/>
    <dbReference type="HOGENOM" id="CLU_837251_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVM9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="39094" checksum="C7A7EBFE93D59595" modified="2013-03-06" version="1">MTVTQKMKNVKRVYEKTKDRSRDDRSKKRTITNKSRGNNESVFRGGKNGMKDGDQELEKENKRKEVLKGAKDKFDRRGDQKLEKEKNTVKTTEELKNKFVQRRDNESKKERNIKKSIKETNCRSASTKDKEQRNDENIRCKEDKKRKITNNELLIKCNGKEKENIESKIKRDSNAESGEKRVDAGCSVVYSPKNRLILRKVPHTTEQEILSHFQLADKARMLMKNDKFTGTVFLQFMNYKKTKKTLEDESLRNFNGHTIEIDYCLPREVYLKKKHLYAENAEDKQENGEKRYDKMKSCDAKEERSKIGETNCKTKKDGVDDTTEKIKRKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVT0</accession>
    <name>L7JVT0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993949">
        <property type="protein sequence ID" value="ELQ75534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1512"/>
    <dbReference type="HOGENOM" id="CLU_628795_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVT0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978893" evidence="1">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="436" mass="50475" checksum="A617F6EA6CAC1D0C" modified="2013-03-06" version="1">MNILLIATLFTKHILFGWAGCSSDTPSCILLTDSNIRTQQYKKFEVMLRDGSVHSVSLSRVKDLWFLIAKFMMGFITMRYRSPQPGNSNKEFQALDKELSGGYYVTQVLDFRRFVDVFSQTMPFPESKSFYRLETPVSALKFVRTFNQAKCEVNLQGLMLYIDDLYNACRVVNCVCRYVFGSVSMAMRPEYADLGSVLSDPYGPFKEMDDLRAKGDDANYVFGSVLDFKSNLKYLSNLQGLFVRYLENGPRLSLLAELCEKAKMIEKELSENEADYNKYLCNTEGFCTWLFRQLGIVGYGGRGRSLFIHSVRLRDICQNWSLRGLCNQCQYYESYGDPHMLLLMERVKENGGVLPPGLRKSRERFWDWRNKNVSTDIMVNIVKLWDRLTEKESDEFDEKHRDLFTDIYRVACRTYGSSWLNSTLYMVDTSCVCSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVU8</accession>
    <name>L7JVU8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="11" type="ORF">THOM_1629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVU8"/>
    <dbReference type="FunCoup" id="L7JVU8">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1629"/>
    <dbReference type="HOGENOM" id="CLU_099537_3_3_1"/>
    <dbReference type="InParanoid" id="L7JVU8"/>
    <dbReference type="OMA" id="DLWMNIH"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="91" mass="10446" checksum="1E59D071383452BD" modified="2013-03-06" version="1">MYPVTLVRISKGSVIDVELKNNDTYRGTLVACDLLMNLRLKNVRLVSSDGEKDFNECILRGSAVKHIKLNNKVLYVQEMVERKRLMAAEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVX9</accession>
    <name>L7JVX9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993954">
        <property type="protein sequence ID" value="ELQ75470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1574"/>
    <dbReference type="HOGENOM" id="CLU_938642_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVX9"/>
    <dbReference type="OMA" id="MRVRTQM"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="297" mass="34156" checksum="426F965AC607AD25" modified="2013-03-06" version="1" fragment="single">VCRRASRRISSYAAIAVIRRNHRSLRFRRISLALNYRTVICALPRIWTQKVNMKKCVQQPDQIFEFVPTGILGCSDMRDQRDMWPWNVERGIGESMYRRFGGHGGAYYPDDLLHAPYYDRVPGIVYTDGYGDRVVQNPLYDYPSERFIHGAAVHDYPSEHFVHEQTVHGTPLYDNYALPPVRETQTVIHETDTHPRYVRPAVHVDPIHHPVIHTEEQPVVIDRPVVQDQLHSEKTKVIPGKTTVETKTVPVKMRVRTQMAPTTQTVVTETVADQEAINEEADASYDEETDVEDVNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVZ1</accession>
    <name>L7JVZ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2168"/>
    <dbReference type="HOGENOM" id="CLU_2580504_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVZ1"/>
    <dbReference type="OMA" id="VRAWCAI"/>
    <dbReference type="OrthoDB" id="10393085at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="9417" checksum="CB564113AB5CA538" modified="2013-03-06" version="1" fragment="single">VYLLCTNLLLDLLRLLLVKKLKNTFFFKMVAGSFIAEIVVYLVLVKDVGWVRAWCAIFFGVFSVGWMVFLHPCYISEHKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW45</accession>
    <name>L7JW45_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotidyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.3" evidence="2"/>
    <dbReference type="EMBL" id="JH994000">
        <property type="protein sequence ID" value="ELQ74982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW45"/>
    <dbReference type="STRING" id="72359.L7JW45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2080"/>
    <dbReference type="HOGENOM" id="CLU_649219_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW45"/>
    <dbReference type="OMA" id="DDYECIV"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="278"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="423" mass="48663" checksum="E740BA2917FAF9CC" modified="2013-03-06" version="1">MAYIKNIVKLDRKEDTLSLICHLLHTDMLAFVQVCFECNHHGFIRRYHQVIHQIKTFYGLNGVIIFTFENVNGLNELQEIKWDKCDCLERFDGLKDVIAGNAGDVWKWCDLKDLNDDGMVRNGGRSCKDENGTKHFSEKERGGNVTCCGNISHNSGRRRKVGDNTVYIRGVKGTNDEKAECVRVDRTRDQRKGSNRVINNPEHELKLKCYGGALYCEQNMLNETREAQNHPQRNLHSKTVEPLEYVCGDDNDIMKKYQTMNKHIFIPPSNTKKYRTVVLGGTFDRFHEGHVLLLSTALLLTSDELTIGLTTKRLQTNKKYNTIIESYNTRRNKLLFLCRVMSNARITLNKLNDSVGRCLTDDYECIVVSTESFTRACEINFKRMDEGKEMMDIVVTPVVEYENVKLSSTGLREKDIVHDRSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW88</accession>
    <name>L7JW88_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993932">
        <property type="protein sequence ID" value="ELQ75728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW88"/>
    <dbReference type="STRING" id="72359.L7JW88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1314"/>
    <dbReference type="HOGENOM" id="CLU_698653_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW88"/>
    <dbReference type="OMA" id="TNCADIG"/>
    <dbReference type="OrthoDB" id="10631674at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="395" mass="44639" checksum="60B92E72707D972F" modified="2013-03-06" version="1">MGLELLNKKGEYFIIDSDLVPKLVDEKPDELWLFIKKRSGTNDISYARMGERCLLYGKNNQLVGKKCSDIGPSVEDNGFSVHIRTGKLKELSDLMWMEDGKIVKEKNRKNVEEQVVDNESQEEAKEDYVTEKFEDGMPVSKENEDGGKGERRNGAKKRGRDDEDEGPERKKAGSRGKKRGRDDDDDEDAGPERKRAGSKGKRKSTDKSDEDTKPGRKRRRRDEDEDEDEDEEPERKKGRIRAKAGNGDEDEGDEKKPRKTTANPKKSTSDKENESPDENGENMGGQVKEAVRKLNKLVKEMEEKNRSKQKLMDDRKRKKESQRSASRERQSNLKSNAKNENEQKPEGEGPLESTANILGNAAGLAVDPTKKLNMALSAAETLKGLLSPSKNKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW92</accession>
    <name>L7JW92_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Meiotic cell division protein Pelota/DOM34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW92"/>
    <dbReference type="FunCoup" id="L7JW92">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1341"/>
    <dbReference type="HOGENOM" id="CLU_776589_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW92"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pelota N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="eRF1" evidence="2">
        <location>
            <begin position="253"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="354" mass="40179" checksum="C7FB4818692DB149" modified="2013-03-06" version="1">MIINSLNHSTHTLRITPTHPSDIHILFQNLLPSHTITMPTTRKIEINDQKKRVSINLTIRVCNVTIDLENSLLIVRGQIAREIENVKMGSYHNMNIGLNDCFSLEVQGDLWRMVDRLVRDIVVFMVIVFRNGKYEVGVVDEYGVECKGAYKKKEFAKFMKDRCANGAQKSDRSDISQASRGKDRQKDAKHGTTPITNSYRVKYIVCNFDVASFVNTSIPSHTISISKEHEKLPLKALIENILSNLTNTSIPFVKDLMVANQFLKMYERADDLIALGIKDVLAAIEFSAIDTMIVTVGLYCTYDVEERHRIRKMVEMVGKDKKVVIISDGHACGNKLNYIGGIGAILKYNYKEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW94</accession>
    <name>L7JW94_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable glutamate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">THOM_1707</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW94"/>
    <dbReference type="FunCoup" id="L7JW94">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1707"/>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="InParanoid" id="L7JW94"/>
    <dbReference type="OMA" id="WCIRARI"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="143"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="474"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="549"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ELQ75321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="633" mass="73678" checksum="C1646E40704518C8" modified="2013-03-06" version="1">MQIRLNPADKRCFVFYYLIKKYTQHDVILDKNKKDVDIDVLESLLEGTPVKQFLRKVYSFELELNEALLQFKKETDALKDVYFALLYENGALLKAMKNEKKLEEPATDKNERFSGVLSVLLEDVRNNTIVEQYKKEMKPKETCRFPPEPSGYLHLGHVKAALLNNSMADELIVRFDDTNQEKGSELYEKIILEDLELLELKEHRLSRTSDYYRTIVTCAQYLISEGLAYCDNTDQEQMNKERMEGIQSVKRDTKPVDNMRIFHRMIELGEEEKRGHGSEYEQYCVRAKISVDDKNKALRDPVIFRLKEKKHGRTNSRLSPTYDFACPIVDSVEGVTTVLRTNEFRDRNAQYFWFLNSLKMRVPVIKDFSRLNFENTILSKRKLRTIIEEHDLTWDDPRIPTIRGIMRLGLNINVLKEYIVMQGMRQKNTINSWDKIWAMNKKYLEKTCKRYSGVYGECVKICFVDCKDAPAEPLEAALMIPYNKKDLLMGQRTVFTSNMVISREDAELLADNEEFTLMHIGNVVVRNKQPDKILIMNKPDGDVKTTTNKITWVSLEGAHTVNLAVYGDLVVNGKFNTESKTIIRIHAEKAVEDVKCGEVIQFERIGFARRDYKSGDFIMVPYTEQKRKAGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW95</accession>
    <name>L7JW95_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.43" evidence="3"/>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2007"/>
    <dbReference type="HOGENOM" id="CLU_1760073_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW95"/>
    <dbReference type="OMA" id="STHSVFY"/>
    <dbReference type="OrthoDB" id="2189737at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01610">
        <property type="entry name" value="PAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="17632" checksum="8C25316B2EC4FC37" modified="2013-03-06" version="1">MVVDAFFTYLPLVLCIYHLRGLTRRSVYHSNQIIRIALCFIVSNILKLYFRMDRPGDVNRGYIRGIVDNGIYIFTSNYAFPSTHSVFYTQYFMYNMSVFTFLIGLFGIFTRVFYNHHTPQQVFFGLCFALFMEISLLNRFKLRKKICY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWA2</accession>
    <name>L7JWA2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWA2"/>
    <dbReference type="STRING" id="72359.L7JWA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1463"/>
    <dbReference type="HOGENOM" id="CLU_578949_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWA2"/>
    <dbReference type="OMA" id="KIYGHYF"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="472" mass="53586" checksum="1DAB50024115A80B" modified="2013-03-06" version="1">MLENIFNVAGIAQKNHVMCQENNVVYYASSSNVIKCKNNKIAPIIRQGNDITNLKVRDGIILSDKDNCVELNNTVLFESNDAIQAVNKSKFVLHDGKLRDVKAFCSFEKIYIFCEKSIFYVEQEGVITLDCIIIDGTVFLVCGTLDGKILKFTIKLDNLLESHKIGNNSLQTNSSHEYERFYLEERKTDKIMDIKRLEKYTVENIKAHDDAVTDIKINTSIILSSSQDKTIKIHNLQTFEHVDTLIGHSDYVYESNFVDKHNEIVSAGADNCVIIWEFRDGWKSKTRLGNLVSTPFYSALVINEKCTSFENGYDNEIEQENEYFVMVHSYNGGIYRYCDTELVHSVGGHVDKITTLAVKNDFILTGSLDRTVRLYYKMKEVARPCIHGYSIRSAVFYNDNVVVGSDESILRVYERTTGVEKILRDVDLKMNVESGDSALVTAVADNKCEAQHENVLFIATPSELSLTNEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWB1</accession>
    <name>L7JWB1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exosomal 3'-5' exoribonuclease complex, subunit Rrp41</fullName>
            <ecNumber evidence="3">2.7.7.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="3"/>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWB1"/>
    <dbReference type="FunCoup" id="L7JWB1">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2022"/>
    <dbReference type="HOGENOM" id="CLU_1147875_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWB1"/>
    <dbReference type="OMA" id="INERRVY"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="57"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="242" mass="27180" checksum="A95E71E024B11E1F" modified="2013-03-06" version="1">MRRYYTNKPLLVDRTAKYFLLNIFDPMEVQNELGLRVDGRLPCEIRRVDICYLNEPSIVYTQGLTKIRVSIAGPKPKSTKFNLNITVSINRSARTEINEWGRLADDHKHRLHNLFKTILILKPASSVDIDILVLEDNGSLYSAMVNSVSVCCAYAGIQMLDLVLSCSIGIYTQADLFDLCGAEEDCKLPSFTICYGTNRKTLFGTSLVGSIAMDRIPNLLNSAVNCIELLRDRVVPSLKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWC1</accession>
    <name>L7JWC1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1426"/>
    <dbReference type="HOGENOM" id="CLU_3263269_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWC1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4721" checksum="A86BE2630C694C9B" modified="2013-03-06" version="1" fragment="single">VRLSTGSEMKKYIFKGMNNETNKNVCGIGNACFRVSKRMFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWD0</accession>
    <name>L7JWD0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein disulfide isomerase (Prolyl 4-hydroxylase beta subunit)</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWD0"/>
    <dbReference type="FunCoup" id="L7JWD0">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1234"/>
    <dbReference type="HOGENOM" id="CLU_036412_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWD0"/>
    <dbReference type="OMA" id="GTTHNDF"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979087" evidence="2">
        <location>
            <begin position="23"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="276"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="451" mass="51189" checksum="5C3DA66760F5FBB6" modified="2013-03-06" version="1">MMRKMIAFAILSLVVARVAVRGDFSEEEMTSLRQTADVKQTKDERPVIEDKGVAIQVDKEDVQDMAECVQSALQMPSDMKSIAAELEKKRNEALIDQVRAGKRTFFIFFADQITNEQKQQIMKVKEDDIPYFISSDKKLAKSLGASFPGVYAFNTTENVSYRINIDHAFGTVMAPVLSVLTSDAIRHIDESKLPAFYIFYTGTQDKQLRDEIKSVATDLRDKYKFGMLRYIPGRTDLNHFKVTEEQMPALVHLIEGKKYRLVNVTRDALVQFIGEYAKGQLTPFVRSEPVPQEQTDLVKVVGTTHNDFVSDDRRDTFIVYGSETCPHCVSLLPTIEKLAARTKDNTKVKVGYINLYENDVPDVNIKAFPTIMLYAAGKKEPIEYKDFNRTEENFISFIKENGSLGVDLAKTGQNVSEEDVKDEAAKKDLEKKIEEVKSEIKEKVEAVKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWF9</accession>
    <name>L7JWF9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-finger-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWF9"/>
    <dbReference type="STRING" id="72359.L7JWF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1683"/>
    <dbReference type="HOGENOM" id="CLU_128868_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWF9"/>
    <dbReference type="OMA" id="ESYCRMC"/>
    <dbReference type="OrthoDB" id="5595379at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125:SF2">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="1">
        <location>
            <begin position="73"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="171" mass="20785" checksum="C47BF6590C427DBB" modified="2013-03-06" version="1">MKRNNILNLNHFFCYDQNNEAITRESLELNSFNDILDIEEYYLNKKTNDTCDYGVYYDFIPEKQLNKIETAAKEMYRPKHVKGKGILREGYCDSCNKWFRLKTSSYWYHMNYKHGINSKGKKYPQPYLREMYNRLESYCRMCDKWIFLCSASGKKSVTYAWYRHFQKNHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWL8</accession>
    <name>L7JWL8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1352"/>
    <dbReference type="HOGENOM" id="CLU_769840_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWL8"/>
    <dbReference type="OMA" id="NENWEIK"/>
    <dbReference type="OrthoDB" id="2190892at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="360" mass="42674" checksum="F214F4E5FEC72C0A" modified="2013-03-06" version="1">MEQLSFSSQLNAPPNIKTIKEYEAENEQLKTENFQLMHQLSYYRNRGDADMQLVNKNDVESLELENAQLKKQISAMIEENNKRMKLDEERNQELLGYKVRERNYVARESEYKKAMENYKSIETEFMEKEKKYSKMISDLRAAEKNLNDQMKEYNNMIEQLTMQNKVHVEKNNYLEKKLEDTMCVLEALREDNNDNITNLSKLNEQKKFYDNIISEQAEKIKNLEVNNNFLRNEVKNAGTASHLRDEENKRLLNENKHIKDLLEDERKRMNDNMNEMEGMKLRTEQNNRIELENTKRKAQQLAAENTKLSSAISELENKLEGIRNEYEKILKNIAPLKVSMPLLSTSLKVNRLMLMDINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWR2</accession>
    <name>L7JWR2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone H2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWR2"/>
    <dbReference type="STRING" id="72359.L7JWR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1887"/>
    <dbReference type="HOGENOM" id="CLU_1939594_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWR2"/>
    <dbReference type="OMA" id="IPMASTK"/>
    <dbReference type="OrthoDB" id="2192075at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="2">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="130" mass="14301" checksum="0860E619FC32CC03" modified="2013-03-06" version="1">MASTKSTDPKQKAEDKEHSQRTRRRTNPKNLESSALYKSSVKRLVRERLKDNYTISSAAVTILSSIAFDFFNMIGTTAGDLSKSVNKLTVGATEVKSAIRLELGGRELSNNIVVDMEAAMKKYGGKSAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWV0</accession>
    <name>L7JWV0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Tetratricopeptide-like helical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWV0"/>
    <dbReference type="STRING" id="72359.L7JWV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1062"/>
    <dbReference type="HOGENOM" id="CLU_466285_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWV0"/>
    <dbReference type="OrthoDB" id="10004495at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="585" mass="66615" checksum="94AA3DCEBBA7C241" modified="2013-03-06" version="1">MWCEIAIVYDMIGNFKMYKHAIENALKIRNGVEALVIYSRSIGVQPGQGAGTNYINAFVKEHRRTGLSVLLECYALLCDDQIRKFERRYGELTECGRVLENEVQRIESTECCACVGQHSCACQDIINSERPSSYVHGSARMSGKDAFINNESVDFFSDAYGAKTGRATIRDLRDKRYEEIRALEMSGILCAESSADREEAELRDGTANITMVKKGNGVKDCNDEDDVKDRVSVKDEDSVKVSVKDGDGVKDRSDAKDNVNNTNCINNFKTHGRGDCENTNKQNVAERTNTPGIASARNFYVLNKHFYLFFLSLVTAYHQRINKLHLSYNDILQYLSHSYRQTERSLMLFRLALILKQRRDYKSATRVLNVLSILAERTHCAVSVLDVHAQLAHLHFVQGATTECRKLLNAILHVDHHHLFSTVLKMECLYTTDMVACVRYCSRMAGRCVQGEYFLLRCYFSLGMIEQCFDVYTNRERSREYSAECGRTHSSPEIDKYFANTIGIVYFNLKDVSSSMAAFKRALSIDSDFKEARYNLALVQHIANSLSTNDFNVYAFNKTKFKEVMPSVSDPVFLPPYFFINCINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWV3</accession>
    <name>L7JWV3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1241"/>
    <dbReference type="HOGENOM" id="CLU_2211804_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWV3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="107" mass="12581" checksum="7D16587BE5DA3D4C" modified="2013-03-06" version="1">MHSALTSKKDWYDTNGTYRSGENNVQRDVLNGNSRRMMRDRTWLGVTLKYGRRIDGLRVCMRVLTYDLPALRAFWPRVSMGIKKMENKRDDLIDEEGLVWIDEEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWW5</accession>
    <name>L7JWW5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993894">
        <property type="protein sequence ID" value="ELQ75973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1059"/>
    <dbReference type="HOGENOM" id="CLU_437194_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWW5"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="36"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="626" mass="70903" checksum="092B86A7384AD96C" modified="2013-03-06" version="1" fragment="single">VLNSSVKNFLIRVPHQNDVLKVKIRQKNAHVPVPKKGLSNLGNTCYMNSALQCMIDLPLLTTFIRSNTFKGRLTNAYKELLAEYSSDSALVVPAEFRRSVVECTKRFYGNKEQDASEFLICVIERMCEEMKEDEHGARVSSDVQSGTDGMRQHANEFNLFRRNNDNIFTALFFSWLSSCLTCQTCRGVKEKGEAFLSLELPIPNEANYHPSVILTFRERRELVGGKLCVRRRRERAEERTLARNTRTHESRTFVKSIKIFVESTHTVKELLTRTAHKYKTAGLVAVSNAKPFSVLKDTDLIAQHKEVFVFEYDPAREYVWIRLSVCSFVFYTCEIDVPFLVEVRRCDNGMIEGLFGEIMCYVDEEHSYGGDGTCRSDTCKECVGRDLNNNVVGDCRGDDSCKEGDGIGGDYKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWX7</accession>
    <name>L7JWX7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1850"/>
    <dbReference type="HOGENOM" id="CLU_769841_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWX7"/>
    <dbReference type="OMA" id="FCINEIA"/>
    <dbReference type="OrthoDB" id="2193419at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="360" mass="39671" checksum="262E0683564A0B15" modified="2013-03-06" version="1">MLCFAQIPLLCLNIYTFYLRPQRWLQSSRPTSNTTKGLTPYNIQIPDLKPLLDVIVEGCEALDTNLTSIVTQTGDDISTIITNTTAVEMKEIQDVVGNGNTLYVSNLTDLFQATAKTITDLINTITGSEEAETSTLLKEKETALVQAIQALVDSANSQIKNLVDNHTNDEFTGLESLIKTENQTIYTQIQNILADPTNTSPIIPQLKFPDPATIANSIVPGKNQLNDDLVKLVTKLLEQIKAEIQKTEDYELDKEKSIIDAGTTSYVDKLNTIRADILVGVQKITDDVSSTVVTSLLASLAANNLEMKNSIVDLTKKMDQDASAYVIEVTNLEINNLAPLITEYNQEIAKQIIPNLKPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWZ5</accession>
    <name>L7JWZ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993889">
        <property type="protein sequence ID" value="ELQ75998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWZ5"/>
    <dbReference type="FunCoup" id="L7JWZ5">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1038"/>
    <dbReference type="HOGENOM" id="CLU_033361_2_1_1"/>
    <dbReference type="InParanoid" id="L7JWZ5"/>
    <dbReference type="OMA" id="QRTEYNK"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="384" mass="42809" checksum="5B53BCBB0834BB26" modified="2013-03-06" version="1">MSCRKYEAPRHGSLAYCPKKRAKQIRQPAAAAPPDNPADKPHLTSFLAYKAGMTHILRITTRKSNDKKAREIRKEVVDAVSVLEAPAMRVYGIRVYTRGVRGLVLADEYVTKNKSECLLARMVRRYHRSALKKNAGRENVQEDLNDVRARFEKYCATSNVLVKVLMHTKIETLKLDSKKAHVLEVQVNGGSVADKVQYALSVLNTDISIGEVFNEQELISICGVTKGKGFTGVVKRFGVRILPRKSNKGIRKVACIGAWHPAGVLRTVARAGQMGCFKRTLINKKVLKIGNATQSVQTEFDLTDKTINPLGGFVNYGMVKNDYLMVKGPCVGPVKRVVTLCKSYTGSRKLRNTEDIDIKFIDTSSKMGHGRFQTVEEKAAYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXE2</accession>
    <name>L7JXE2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993892">
        <property type="protein sequence ID" value="ELQ75985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1049"/>
    <dbReference type="HOGENOM" id="CLU_158828_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXE2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="101" mass="11997" checksum="093AFDE851CB8339" modified="2013-03-06" version="1">MIFFNNLPVHLQSLKFVLFVVDILLKPIQNFEKICLKSFTIKFIKDPEVKSLIKKPREVYDIRISMLSQFASFIEFKKLAELKFELNGESMFLDTETYEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXP0</accession>
    <name>L7JXP0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993919">
        <property type="protein sequence ID" value="ELQ75821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXP0"/>
    <dbReference type="STRING" id="72359.L7JXP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1214"/>
    <dbReference type="HOGENOM" id="CLU_122489_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXP0"/>
    <dbReference type="OMA" id="WTTAMEH"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="18895" checksum="10313718DF36CEB6" modified="2013-03-06" version="1">MLVFDLNGTLVKRFYKPNGIITNYDYEYGKFYVLLRPYLRELTNYLHINDLKYMFWTNALAYNADNITQILIKEGMRPVAHLDRQHCTFIKNVCKKDLSVVSKMHNINLSDIFLVEDMETRSVRGQNVILVDKFDGDATDDALLTLIDDLKKIYEDKKNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXV3</accession>
    <name>L7JXV3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0805"/>
    <dbReference type="HOGENOM" id="CLU_2009501_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXV3"/>
    <dbReference type="OrthoDB" id="10428600at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="124" mass="14553" checksum="CF8965200A6E5D19" modified="2013-03-06" version="1" fragment="single">VSAVTMAINAPSRILFTYVIMRLLYDKIYGWDKIAGMLTISMGILISNSDFSGNTSDEMLYVLLFLFGNFLNAVGLIYFDRKLRHHIVHFWNYMYTYSFTLLIFNVLLLPIELLYLKEKIFLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXV7</accession>
    <name>L7JXV7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin---protein ligase</fullName>
            <ecNumber evidence="6">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.19" evidence="6"/>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXV7"/>
    <dbReference type="FunCoup" id="L7JXV7">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1136"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="InParanoid" id="L7JXV7"/>
    <dbReference type="OMA" id="RKVTRCV"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990389">
        <property type="term" value="C:CUE1-UBC7 ubiquitin-conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180027">
        <property type="term" value="P:inner nuclear membrane-associated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="180" mass="20280" checksum="40250323D7AAF9EB" modified="2013-03-06" version="1">MAKRSLSIPALNRLKAEEKNLVSDAPECGFLAEPQLQPDGLRDYGTWDIYINGSEGSLYEGTVLHAVIEFTFDYPITPPKMRFISKMFHPNIYSDGKVCISTLHVADDDPSAYESPDEKWTPVHGIRTIVLGVISILNEPNIVSPANVDASKMFKDDYEKYCRTVEALARRESLKRVDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXW1</accession>
    <name>L7JXW1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0748"/>
    <dbReference type="HOGENOM" id="CLU_3320317_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXW1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4748" checksum="FF24DAA5AF331A7A" modified="2013-03-06" version="1">MKIEQQAKEREDTKNESTVTCTNVLMCIKEKRWNVLTYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXZ3</accession>
    <name>L7JXZ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1097"/>
    <dbReference type="HOGENOM" id="CLU_2747200_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXZ3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8498" checksum="1D24E7250AEC1324" modified="2013-03-06" version="1" fragment="single">VKLRDLPNFDRWNDKYFTVRQTSYNLDENHLNSTTILNSNSSTIINDKYHDIIKKLTNSSRLQTMHLINMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY13</accession>
    <name>L7JY13_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0695"/>
    <dbReference type="HOGENOM" id="CLU_2874102_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY13"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="64" mass="7191" checksum="458198553AC39DD4" modified="2013-03-06" version="1" fragment="single">VMSGEKIKISTKEPDGLEDLVATLLGKVNDINNNLEQMTRRIDEILSDITEDISDSKDEDEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY86</accession>
    <name>L7JY86_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY86"/>
    <dbReference type="FunCoup" id="L7JY86">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1019"/>
    <dbReference type="HOGENOM" id="CLU_027721_3_0_1"/>
    <dbReference type="InParanoid" id="L7JY86"/>
    <dbReference type="OMA" id="CFTKMDH"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="87"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="278" mass="33647" checksum="9477E3DE54A35E83" modified="2013-03-06" version="1">MFVVSYYVVMFVHIQKIYKYRQNIYLFYVVNYVSLYIMILLLQIVRASTDRLMHKMRNFSEITEESLDEMFNPFFTDKILMRRIEVSKTCGKCYAYMPPRTHHCRICDACFTKMDHHCFFLNVCIGLPNYKYYYLFLLINWIYSTFLFILLLYFAIAVKQTPNRMTFYVIGIISNCIILVITFIFLLFHTRLLLYNETTIERLAINEFLAGDDNYKGIFQEGLLSTDEQIDIRDRKLLNPYFLGYKENIREVFGDRYYEWIMPYFTSRSNGIYFRKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYN3</accession>
    <name>L7JYN3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993915">
        <property type="protein sequence ID" value="ELQ75852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1190"/>
    <dbReference type="HOGENOM" id="CLU_2172831_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYN3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="13111" checksum="942A004CDB85AE72" modified="2013-03-06" version="1">MTLPNFGLKLSFANRYSSYTWIQGITLNRISTYYIIVEMICQQPRIFERVLRKRVLRILNQKGFIFVELSKLKETICIHIDKLDELDPCFMMLKAHAIDKFIRLRLLENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYP8</accession>
    <name>L7JYP8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993910">
        <property type="protein sequence ID" value="ELQ75872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1167"/>
    <dbReference type="HOGENOM" id="CLU_3421425_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYP8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="24" mass="2821" checksum="776B5168CB8D8AAD" modified="2013-03-06" version="1">MNNKPVEMVSGYEHLYVLHSCKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYQ3</accession>
    <name>L7JYQ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Splicing factor 3a, subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYQ3"/>
    <dbReference type="FunCoup" id="L7JYQ3">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0308"/>
    <dbReference type="HOGENOM" id="CLU_1070337_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYQ3"/>
    <dbReference type="OMA" id="IPHWLYK"/>
    <dbReference type="OrthoDB" id="2189371at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="6">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="260" mass="30959" checksum="375B4CF72B5D6AE3" modified="2013-03-06" version="1">MKILQKITNFDLETENKFKYLFALLHLQHYLKDFVHKSRPEIHHKKIKRLLRCAESENKTWNVFDTKVYCMFCEMDITKSVFEYHAKGKKHGKARTAFLKNIELPDENGDYVRNKCENVYLKRKVEYICVSSAYVNRLEARVKLLLTFLEKELKLAVSVRGTQSIMSIEKEKKTYSMKIYRDEAGNPIPRWLYNQRGLNVEYICEICDNTMYKGRKVFESHFNSDKHKQCLMKLGITSNFDKYRGISQIRNAQKLQDKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYZ6</accession>
    <name>L7JYZ6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYZ6"/>
    <dbReference type="FunCoup" id="L7JYZ6">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0772"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="InParanoid" id="L7JYZ6"/>
    <dbReference type="OMA" id="QDIGGMD"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="176"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="396" mass="44490" checksum="80740E8196B88DBD" modified="2013-03-06" version="1">MSSKTQTKEDNDMFALKVYEKYKSKQYELEILCREEQQCIKDINILKSELIRAKEEIKRVKSVPLIMGQFLEAIDKQTAIVGSTTGSNSVVKILSTVDKELLKPNTTVALHRHSSAIVDVLPPDADSSIPVMLEAQRPTVTYDDIGGLETQKQEIIETVELPLKQFELYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANKTKATFIQVNGSEFVQKYLGEGPRMVRDVFRLAREQAPSIVFIDEVDSIATKRFDAATSADREVQRVLLELLSQMDGFDVTVNVKVIMATNRADILDPALLRPGRLDRKIEFPLPDKRQKRLVLNAITNKMNLSDEVDLESFVSRPDRLSCADLNSICQEAGMLAIRNGRYVILQKDFEEAYSRVADRKVSGPLLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ04</accession>
    <name>L7JZ04_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993837">
        <property type="protein sequence ID" value="ELQ76560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0454"/>
    <dbReference type="HOGENOM" id="CLU_3227279_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ04"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4476" checksum="906B584C3B1D704D" modified="2013-03-06" version="1" fragment="single">VIDQALKDVLSCGSSYCRQAAYQELHIDCVAMRAANLGSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ11</accession>
    <name>L7JZ11_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular matrix glycoprotein Laminin subunits alpha and gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0397"/>
    <dbReference type="HOGENOM" id="CLU_1483078_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ11"/>
    <dbReference type="OMA" id="YMDNELC"/>
    <dbReference type="OrthoDB" id="10356681at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="183" mass="21453" checksum="F587B80C955EF9A2" modified="2013-03-06" version="1" fragment="single">VMTLSTAIKSLDNMNALLAKVPKIEKIDAPSKTLMPTMLAEQRKKELLEQLIPFTHKVIQNIEEYITAQPKTYQDIEKKYERTKYMYDSYKSTVEDTDLNGNYEKAVSIKNDINKLNDYIKESSETITFNYENSVKLFDTVEEGIYMDNELCDFINNKFRFEIEGVDDREIEVLEEMLSMLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZD9</accession>
    <name>L7JZD9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0603"/>
    <dbReference type="HOGENOM" id="CLU_1579610_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZD9"/>
    <dbReference type="OrthoDB" id="2189578at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="169" mass="19733" checksum="92C9846027194217" modified="2013-03-06" version="1">MDLRRIIANAQIIKSSTPSFDPTYTSTVPPVIPLDTIEDLTKICSYFDLPQPTKQMFEDETQLEQLILFLKNLRLSLLGFGVQIEEITIDETNIRKAKSIEDEIDKMEISIANMEDRYNLLCEFKREVFKYNLRNLTNTFDETNSTNDVRKKIIPTFLSIKTRQSVVMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZJ1</accession>
    <name>L7JZJ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0141"/>
    <dbReference type="HOGENOM" id="CLU_338077_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZJ1"/>
    <dbReference type="OrthoDB" id="10615653at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="842" mass="95384" checksum="40AF47EF9C55D296" modified="2013-03-06" version="1">MKKTRNLPIFPRFNTTFSTENNKYVMYLELKPCASDNEMNYLHVLYNSNLLPFNVCIEVDIEAKRANSEEEQKKDDNEKKSGADDKPAGQDGTNGRVVSEQTETHEKANFKVNEEIDTGNVDSERDMDSNNNSTQKNSESTGQKPSKNAVCVIDVESHLKDADFSEDVHSDPHGKLQAESVENDPKNVHCGYDVKKTRAFFKMRSDVYSWKRLVDCYFSDTVLSIVITFDERTNQKLSFLFSRRYGIFFLDDEPVNMHSKPCSFVKPKVKSTVFEHKIFMSDDGFKNELMVKSASRVTREGSQIISKNIAGVDIVNGKFVKCENDKVKGSQSSLRYNNRALELDLRLGIYGIHILAHNMFCYDGEFLHIVFGSVSTISIVETVVNRDELKFLESWLRFIDLGDGALVDYSYLWKENPGDPFYYDILDRMHVKIYDIGEAIRLKIDMEDECCDRGCELKHIFTMPKPLDLLVGHSVGDIAAKISIGLNGSEVVYHGSRFYVRGQTIDITPDFSNLAFTKTGAFLSVPTDSVYHQIFAPLCEKYGNIVFTPNNKLFSQRSEDSLRMKVNLDMTGCMVGLNVAVELPEASVGKLNKVTEKKQPQGLRISWPDIKIMLYYDIPGDKRQIIMILQVFSSYLCLRPFGTKVITSYMCQKTLLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGDGRSSDAKKCRYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZK6</accession>
    <name>L7JZK6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZK6"/>
    <dbReference type="FunCoup" id="L7JZK6">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0513"/>
    <dbReference type="HOGENOM" id="CLU_019279_2_0_1"/>
    <dbReference type="InParanoid" id="L7JZK6"/>
    <dbReference type="OMA" id="ESRVYKY"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978914" description="non-specific serine/threonine protein kinase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="319" mass="37272" checksum="D7098749C8B11759" modified="2013-03-06" version="1" fragment="single">VSQLVVLLFLFFLLFSHPYHKKPMNDFSDIQITHKLGTGTFGDVYAFLDCKTNRKMALKIEKKNCNLLRNEYKIYVRLNRTMNDFVCRTYFYGKVRLNNTLNNAMVMDLLGLSLQKLFIRQHKRFSEVTVLRLGIMMISCVEFLHARHFVHRDIKPDNFVFGLGANSDKLYLIDLGLAKKYRSSTTYTHIPHKNGKLLVGTARYASVNVHRGEEQSRRDDLESLGYCLIFFVKGKLPWQGLKASNKQEKHMLIREVKESVSLEVLCEGLHGCFYEYMKYVRSLNFKTMPDYDYVKQLFEDALYEMGHSGNTQFDWSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZK9</accession>
    <name>L7JZK9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0099"/>
    <dbReference type="HOGENOM" id="CLU_1147872_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZK9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978926" evidence="1">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="242" mass="28147" checksum="681CC37FA37D9243" modified="2013-03-06" version="1">MHIFTSILLLSLLIQLADGGVDISTGKERVRTRHILTVKPLYNDEKDELRLYVRLIYMHLHLIAQGIQKALENFNTIVNACKNCRTQQFLIKETKITHTELYNALYVFIADHENVWRNHWYKSIMIIEDDKVQLDLDIIIEIVKRFTKLYEMIVPISNDSLFVSLSDDITLFDQQCGAIVSYVNELFGEMALVKSKGVVFVDTQLYEKLKEVCLKWSILWVESVVGSVSERLGPVYAYFFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZL4</accession>
    <name>L7JZL4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993807">
        <property type="protein sequence ID" value="ELQ76879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0120"/>
    <dbReference type="HOGENOM" id="CLU_272042_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZL4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1189" mass="135020" checksum="75A716F47CB8C528" modified="2013-03-06" version="1">MPITFGRITHSLVKVILFFKSNKPDGESDYIILNSLSEAKLKNYIDNNQVEDIDFKKHIRWYDSRSDVLNLYEKNTDKKTGSSSQDKGNMSSNRDTSRQTTDQDSSTPTNSDNEEFVAYLEIHLPISKELYRKISEITHLNEISLSCEEIYEVVDLNLFTILDNTESIICGIVNILQCDPEMIESLTSYYCERMHALLTTFEWIDISVEEVVEFYNSPGYPSSMLDHIQQSSCRQSLPFELTLGVFHWTNCFGAFVAKVKKHIGVRLKDPMGNELFTLGNVEKSRAVILELQLESLNISYLFDHIKLDSKILMNHKQQIEEKFSLEAGCSNITLDIDFTSLVSDECIVDMREIKSTCEEILSSDLICGDHISTLILRFKALNCEIDASGIFGKKCELFFNGCSWSFIQSLNVAPKTLCLINMTLPKIIELGPELETFICDNVVMVDGQTFTTGQNLKNMQLINVKGCAVKLNEKLTVYCQEKSTIEHTIIGPDSQIVTKLVNVKCNSLHNDHGAPTFLIYGEMSNTYLKNAVPIKKPHHIFLENCRGVISLEEIQHVQQFQLSGSFNNNIRFILPPRIVEFGLINVVLQESLIISDRCDVLKLDSIEAGNNCTIKVDKVCNTIKSNNIMCGINVFDEMFLGVCGGCNNISSFTLDIIKGEGMYDLQIKKATFSIKDNNCQLIQRMSFNKVQLNDTLMINIDETVEHLLLENIAGTVVLSGKVYGTFTANYAISAAKLEIKRQEVDKTYDITIDKMAFDNMVIINCNTNKLLLNSVKMMNRNFLRINGAYNELTVNNYSGIINIVDGGFLLHEQNLTEVSFAYNKKLALVSINTWPRMSNVDLTPEIKNISINKADVVNLHAFYLRKELESVSITNSTGNFFFEKMLNLFNLKLEKTSIVMMSDMQNDKLQVALKNLKLEQSLQIDKQAEKILLEKVTMADGAAVCVTSDCKSIEIQETGCYIQWLSDTGSFHRFVCRPTVNYEFGKCSGDGNWFCALKKAHIQEHINFPPIMRSIVLSEIVGDENSAIILDETCKNLLVDQSSISINLRSPRSVEKLTVSFSIVNFIEICFLECAPMRISCLYVFEDDEQSDIKIIVDSESLKTLSFRQDRFYASQEELYATVVDELSTIKQITSESHPQRLENIYMTEDRDLNLINLLENHFRNNISDCKCFGYKCINKVEISLQYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZM1</accession>
    <name>L7JZM1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">H+-or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZM1"/>
    <dbReference type="STRING" id="72359.L7JZM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0529"/>
    <dbReference type="HOGENOM" id="CLU_2374263_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZM1"/>
    <dbReference type="OrthoDB" id="2189390at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979285" evidence="6">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="7">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="95" mass="10606" checksum="EBFF26BA0D0359E7" modified="2013-03-06" version="1">MGSTIFVYALILCTLIANRITLEMTVNESMCHFGAGVMFGCSAYFSGMAFGEVCKRSYLTLEKREGFYIIFICTLSAVELITLFGFLISLFLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZN3</accession>
    <name>L7JZN3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0095"/>
    <dbReference type="HOGENOM" id="CLU_900755_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZN3"/>
    <dbReference type="OrthoDB" id="10533478at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="309" mass="34794" checksum="32F0B4A498742792" modified="2013-03-06" version="1">MILSHYKEYYCIVLRIINTFCVISMNKMFNMHKHFYFTLAMHRVIIIGSSPAAYTAALYTATANNKPLLFIPPVTYNVRNYERIVGLPDMTEEKFGCLMRAQLERFGVEIRVVDHIEVVEGVKDGNEGVDNEGIGENYENKDVCDENGNEGIGENYENKNVCDENGNEGIGENKDGRVEHGCVKDSDKEENDGEERSKEMIGKHIKQDELKEDDIDEGLLLLEQQAINESAVRITGGACNDKRNDELRINKEMLVVNGEECLALITDHDIGINAHNVFMCGGEEAIVAIGNGCMAAIKCNEYIERNWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZN6</accession>
    <name>L7JZN6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0836"/>
    <dbReference type="HOGENOM" id="CLU_2980753_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZN6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="6346" checksum="6178D8C1D22F5DF2" modified="2013-03-06" version="1">MQIWYECTSVPLVQLYGIVHVYSHVGLLGNGLNGNGVIVEKGVNKNGWFVLPSNDGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZQ8</accession>
    <name>L7JZQ8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JH993805">
        <property type="protein sequence ID" value="ELQ76924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZQ8"/>
    <dbReference type="STRING" id="72359.L7JZQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0078"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="InParanoid" id="L7JZQ8"/>
    <dbReference type="OMA" id="MEMAVTH"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="8"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="166" mass="19274" checksum="606E35948421A30D" modified="2013-03-06" version="1">MATIHDSSAKRRIHKELLTLQREANHPDANDKTLRCFEIATNPDDNIFEWYVRLRAPEESMYAGGIFNLKITFPTDYPFKPPSVVFLTRIYHPNINANGNICLDILRESWTPALTVQKVIISLISWLDEPNPKDPLVPEIGRLYITDIEAYKKKVKEYVRLYAKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZR2</accession>
    <name>L7JZR2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GLTSCR protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZR2"/>
    <dbReference type="STRING" id="72359.L7JZR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0068"/>
    <dbReference type="HOGENOM" id="CLU_1134285_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZR2"/>
    <dbReference type="OMA" id="NIDHIIC"/>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015671">
        <property type="entry name" value="GSCR1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15249">
        <property type="entry name" value="GLTSCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLTSCR protein conserved" evidence="2">
        <location>
            <begin position="104"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="244" mass="28685" checksum="186BD44ED8507FE0" modified="2013-03-06" version="1">MNLTTKSTKERKNSNEKVDGPSSHAQKAHMSRRGRKKKQHSSMDISGAHNWAGRSHSGSRKNMVDEHDADAFLSDRTEQSASLVDNIDHIICRRERILNFLYKDQYQLTHPDIRPFENTKHVYEYLLPYHIYNAPSYDDLLFRYANDNDKLMDEIKEVTQRIGRTLHDYECVNDDNIVIDLLLTEEQKFVTSRLSEYLKERKRKPRKSAAPKRRKKSSSIVKLNVKSAKMKDTKVKLRLETHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZS1</accession>
    <name>L7JZS1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZS1"/>
    <dbReference type="STRING" id="72359.L7JZS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0194"/>
    <dbReference type="HOGENOM" id="CLU_1262300_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZS1"/>
    <dbReference type="OMA" id="ANTHSNR"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="4">
        <location>
            <begin position="12"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="219" mass="25330" checksum="D189E52275D982C6" modified="2013-03-06" version="1">MYEEFRDGSIISLQLHNFQTYSDVKFDFHPRLNFIAGPNGSGKSTIANAIAFIFGGSTKVLSKAKDLMDFIKFDTNDSYIEIKIKYTGKVTTIRRALVPLKNSSLWFLNGCSTPYIKIQQMYNELKININNICNYLPQEKVAEFTRFSPEELFRTFIETYHEQNIVDKINTLIDMEGFYDSLSGDLEKILCNKMAIEKVISGMSRDIEKVKEKKRRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZT9</accession>
    <name>L7JZT9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0005"/>
    <dbReference type="HOGENOM" id="CLU_487623_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZT9"/>
    <dbReference type="OMA" id="YLPCRAI"/>
    <dbReference type="OrthoDB" id="10365712at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="560" mass="65449" checksum="2DFC63ABD8C131B0" modified="2013-03-06" version="1">MTEDELFIVLASLTTNPTLEKLQDIEFMLLEQGDLRPFVHKYDAHLISNLLKHPDLFDLVLEILILCLDENCASLYADKRKLFLLTDQLYINRNSRIMTAVTRIVVLNEEHVRVKIVNMLDSLGFFKMVIALACKESAELIDSLFVNDGSMRYTEDERNKIRVMFGGEESSSLLTYEENASYVFDVNVATGDGSFDKMNRNAVANNSDTGILPSNYGEKDELSVDITQGCERGTALEQNREKRSFSHFRNYPFDVKRKYFDIKTYFKEKEYFKTYTRRIHKYNLVFIKVLSIFMINIEYFIFYLPCRAIDFMVRLNECVIGNKAIMVTLKSTLMPYKEDILERFLEKHDCIHALAYVIDRNMLMRKDVLSKLKEIKDSGALFYKFMDDFDVLKQIHGKEWNDVFFSFLVDECEHMQHCMEHNNTKAINNTGMSSNTCLIQCKKYQTLLLLSKLPLVFKISKLMVISRWKAVLKNHACVDNEFLDLYQEEFLNYLRSNYFNFARVLFSEPKTRNGKRHTTKEDNIEDSSVSDHESNATLVEEGNDAYIESENFMSLDDKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZW4</accession>
    <name>L7JZW4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-directed DNA polymerase, Non LTR Retrotransposon</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0732"/>
    <dbReference type="HOGENOM" id="CLU_2591473_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZW4"/>
    <dbReference type="OrthoDB" id="10014409at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="80" mass="8848" checksum="E19D40FC5B697564" modified="2013-03-06" version="1">MASYFVFSRECAGGPCVSVGTGDTRSALFMYDIGVRQGCSASPVLFNLYINNLFDGLSRVTTQLERDLFPACYLLTMLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZX0</accession>
    <name>L7JZX0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">THOM_0016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZX0"/>
    <dbReference type="FunCoup" id="L7JZX0">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0016"/>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZX0"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="241" mass="26384" checksum="39920460EEF820E9" modified="2013-03-06" version="1">MSQRIDFEGSSDIGAYAILTNKYCIVGKSSSRNFYSYFQEHLDIPLVETTINSIKTVGSLCAGNKNGLLVPSTATDQELLHLRNLLPENIKIKRINERLNALGNVIVCNDSVALVHSDVDAESVKNIEEVLMVDVFRHNVGCEPLVGTFSAMNNQGMLVHPRTSVEEIEELCNLLSVSVVAGTVNKGSSVIGGGMVVNDWISFLGHKSTATEVTVIENTFKLVDGRDDENLKKVWVESMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7K064</accession>
    <name>L7K064_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K064"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0493"/>
    <dbReference type="HOGENOM" id="CLU_1286069_0_0_1"/>
    <dbReference type="InParanoid" id="L7K064"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="215" mass="24465" checksum="8F4A7697ED128EF1" modified="2013-03-06" version="1" fragment="single">MDRESINQDVTGTSNSTSTDSITSNLSSIKMRIAELKRTFESYLSTDSYENMVKTQKTPETPENPQYSSSNGEFIPIPEPISVFDKNVLLVELLSYTETRLDYMKAFVAQIHSLEEINNPPFRKVENSKKAENVTTIACSKYVTITRKEVEGSKKVISEFENGVENVCDMFITSYLKLSDALLQIRKKEIKFENDQVKQLQHENDPLNGMLGINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7K091</accession>
    <name>L7K091_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993844">
        <property type="protein sequence ID" value="ELQ76527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K091"/>
    <dbReference type="STRING" id="72359.L7K091"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0487"/>
    <dbReference type="HOGENOM" id="CLU_077727_0_0_1"/>
    <dbReference type="InParanoid" id="L7K091"/>
    <dbReference type="OMA" id="WGDWAGP"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="29070" checksum="746481158AC156AD" modified="2013-03-06" version="1">MKSDKQNILMIRQKKTRIAEFDKKMKRIKQIKSRKYRKHLKIARRNETGDVKIPDFLLKNVEEEKKDKVFFDEGLSDKIGKIMVPEELIDSVSTDTEDELFKDGSSVEDEHLEIFKKEKMDHVKQNMPEETTMVLPGWGSWGGQGLETKQTSLNTICSSKEGIVPKRRKDFRMGRVIINENALKNNIKIDLPYGFNKLEYEALLNMPVSKESNTLKIFQKFLKSEEQQNSEVKTFDEFEYASKYDNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K092</accession>
    <name>L7K092_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K092"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0190"/>
    <dbReference type="HOGENOM" id="CLU_2795739_0_0_1"/>
    <dbReference type="InParanoid" id="L7K092"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="68" mass="7569" checksum="EA20FB09C3398BC5" modified="2013-03-06" version="1">MAFSSSEHDVNAQGYDARITSVLVITGQSESADRHDRPRFDTRAGLRLLALPTDVRDERLRASRALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0B8</accession>
    <name>L7K0B8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993809">
        <property type="protein sequence ID" value="ELQ76876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0B8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0135"/>
    <dbReference type="HOGENOM" id="CLU_566438_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0B8"/>
    <dbReference type="OMA" id="DDIDKYW"/>
    <dbReference type="OrthoDB" id="2195577at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="527" mass="60072" checksum="4B2EBE1CFED4C383" modified="2013-03-06" version="1">MIKPSINYLISMFYPESMYSKALVVYFHFHVPSLLPCNFDNPSTTQAMRLTYKPLQRRKSKMLTTVNLDDDIDKYWTNATKVLDNDVYDLEEFSFLEKSVNLEEMDGKGNNEKNIEINDMRERTEYEHRNVMNNKQDNTMNVQNNVEEQNDNNVISNEQNIGTTNPKRVDSDNSINSGAKVDGDQHFINFSSLEENSFSIGRDSDGVVSSNEKENNHVENISGIKAGKDASSTRDEKDNGLIAEAEPEKNSKMRDFNLRDSDKKKKKKSFFDFNTMKKIETAYDDDVSVDGVVEDKKEDLGGACNVVEDFPAEDDAVDYNVSRAEYEDEYAIDQNEESTNDAQQEEYAGQHDTSIGAVERDAYSRETAEERSKTRMKREELKEIVSVMPMRKSGKRKILQNKTNKKKDTAERDSKRKRRSSSNENMDSNIVSNISARQAKNGFVPLVIENNLETAVLNLQENAYIEDEAATKSFSFYVTKGKFTIKRGDKEFLLKRDGMLVINEGESFVCKGVSRGGNTGIVTYKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0C5</accession>
    <name>L7K0C5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0C5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0092"/>
    <dbReference type="HOGENOM" id="CLU_2980752_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0C5"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="6713" checksum="7E7FC178AF8F4DE0" modified="2013-03-06" version="1">MRISYDDEGGYERLMEYNRRMVGGEMVGVFRERWGAVGECFVGRKGVLVKIIEYLFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0F3</accession>
    <name>L7K0F3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0F3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0013"/>
    <dbReference type="HOGENOM" id="CLU_2795738_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0F3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="68" mass="7865" checksum="8F0C7263918A77F6" modified="2013-03-06" version="1">MLMMYESTAGILLCRIDDGEKNEIKIVDKYLFKENKEAINILGEIKNHKIGDNLCGFLKKTWAKTSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0H0</accession>
    <name>L7K0H0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993831">
        <property type="protein sequence ID" value="ELQ76717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0H0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0288"/>
    <dbReference type="HOGENOM" id="CLU_1059901_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0H0"/>
    <dbReference type="OMA" id="EYKARSH"/>
    <dbReference type="OrthoDB" id="10293110at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="243" mass="28838" checksum="334D0DA2DF8AD72F" modified="2013-03-06" version="1">MTFITSKGCFEDNPDLLPKFLAIKDKEPKVFVVEMLNNMVNYILRNFLDQKVINTVSTLALKRIAIDSYNCRLLRKLERLKVLQIRTKHITGEVLYNLPPNLELLDITNLFIEKVNWTEKYVIKPSIIIQPYKRLKILVIDVEFLYNVRTLSVLMPSLEVRYSPLITTNPLIPWKKVKINELFIQCDNFRRYHRHVLKPNKDGMVYFLEKLKFYIEFDSLQCVAFVLSDKYIFFDPVTLKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0K8</accession>
    <name>L7K0K8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0K8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0103"/>
    <dbReference type="HOGENOM" id="CLU_1001840_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0K8"/>
    <dbReference type="OMA" id="RRGICEY"/>
    <dbReference type="OrthoDB" id="10430719at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="276" mass="31468" checksum="2A7873B3CB28489E" modified="2013-03-06" version="1">MLILHILTALTCTIDTHYEVPIKVVFEDIAFRKIAYDIIESADEIPKKRKRLEYARAEESVRNMVEGVENYVNMLLSDLKVSVSLEMVYENANSASEQICANPHRMRSVLKQLKINTNTIYVVGCTMPAYDESDREENSNDKLEGPERSIYINASNRPDSNKKMNVPTGTNKTSVKHKKTSFEINQAMMIQHLAMLNNIRAQDEKRWSISFEKQLTVNMSRCVMISGVYLDENLVYNLRKAAMEITGGGTVRANVDVEIRRGICQNVMECYDGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0M5</accession>
    <name>L7K0M5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0M5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0019"/>
    <dbReference type="HOGENOM" id="CLU_2020863_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0M5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="123" mass="14814" checksum="3904AC3F5D9FF900" modified="2013-03-06" version="1" fragment="single">VLLHRINLPLGMVIRRKKEEISKQRRKRREKMDDRKKESKEDRTERSLRKARKMKKKADDVKDTNTKTCEMKQEKHKKKRGRPSNSKIELNPIKSKSEMKADSCVIEKKTKKIEEKVKKTEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRI7</accession>
    <name>L7JRI7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_3178</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRI7"/>
    <dbReference type="STRING" id="72359.L7JRI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3178"/>
    <dbReference type="HOGENOM" id="CLU_1332303_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRI7"/>
    <dbReference type="OMA" id="CYEMVNN"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ73900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="182" mass="21334" checksum="9FED95CF7A89AB74" modified="2013-03-06" version="1" fragment="single">VPLMNELYEKYVNLLKENNDLKLRIAALEHSLSKIGNTDTAAHEQKENESNAFLVERLEKLEKEKLEWCANSNCTVYRHQEELRQLTDHYKEILKDIRKNVTGLLGYKLDVIDDQVHLHSLYSFDRDDVFTFNVKEDCYEMVNNHFAEGYRKEIDTYVVKGRSVPALLAHVTLDLVSKKTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRR4</accession>
    <name>L7JRR4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3083"/>
    <dbReference type="HOGENOM" id="CLU_3088972_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRR4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="52" mass="6055" checksum="25454D4FDD74006D" modified="2013-03-06" version="1">MVYLVFDSYLKIIFELIRQLCTVQKGPKFCGLVSSSLSNYPHETKKEIQVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRS8</accession>
    <name>L7JRS8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_3098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ74005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRS8"/>
    <dbReference type="FunCoup" id="L7JRS8">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3098"/>
    <dbReference type="HOGENOM" id="CLU_155991_2_0_1"/>
    <dbReference type="InParanoid" id="L7JRS8"/>
    <dbReference type="OMA" id="IYDPDMF"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="10451" checksum="29F7D642C1509CA2" modified="2013-03-06" version="1">MPSFQNKVFTPEEIEIYFEQAQPYYDEIDLDDFTYDEERNAYVYPCPCGDKFVITVDELMIGETKATCPSCSLVLKVSYNFDDVEEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRZ7</accession>
    <name>L7JRZ7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_3261</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRZ7"/>
    <dbReference type="FunCoup" id="L7JRZ7">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3261"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="L7JRZ7"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="7"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ73821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="294" mass="33838" checksum="CA3D576E6DAE0E27" modified="2013-03-06" version="1">MSSTDSYQRLEKIGEGTYGIVYKAKNKSTNKIVALKKIRPENEEEGISTTTIREISILKNLNNNRIIKLMDVMYSNSSIYIVYEYLETDLRRFLDDCISQGTTIDKDVRREMARQMVEGVAFLHCNGILHRDLKPQNILIDGNGNIKLADFGLGRTLRLPIKTLTHDVITLWYRPPEILLGSKHYASSVDVWSLACILAELFTLKPIFPGDSEIDQLYKIFMILGTPDNTNWKNVTYFPNYQESFPKWEPIDLKIILKDGLFTDLIKSMLRYDPLDRVSALHAIDSPYFTNIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS16</accession>
    <name>L7JS16_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2986"/>
    <dbReference type="HOGENOM" id="CLU_1278479_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS16"/>
    <dbReference type="OMA" id="AMSKNEC"/>
    <dbReference type="OrthoDB" id="10415197at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="239" mass="28068" checksum="3628C78CBA2780DD" modified="2013-03-06" version="1" fragment="single">VISTLIKKYKYVISSSAMYIFSILMSVGAITEKEVNRVLDEVVQKIQMLNQQIDLVTGSMSSMKQIRSNFVAMSKNECVSKNLFAFHFDKFAATRSNLSEYFLAYENFLCFLPYMINTVTITSIDKQNTKKVIDLKAMKKHIKDSEFFKNYTDEIYLNVEKLKGFETRLYECLEEIRSMVAKFDYFYKRIENGVILDIFSIKALNEHHYCNNCNSLPLSEEFYRSIRTFQQSNKCPEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS72</accession>
    <name>L7JS72_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3174"/>
    <dbReference type="HOGENOM" id="CLU_845154_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS72"/>
    <dbReference type="OMA" id="TWENKEV"/>
    <dbReference type="OrthoDB" id="10392526at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978763" evidence="1">
        <location>
            <begin position="21"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="329" mass="37626" checksum="B262DAF00498C77C" modified="2013-03-06" version="1">MNFLHIVIFALYKMINTSSAESESNPIQAISTEAFLPLDLLTPDMEKVIKVVVSNTTAVDDELKKRIMVRLEQMNEELDKITTDEMVKIRSILEKNQNIFYDGVVKDYTGFIEKINEVEPLLKNILDLNVLAEGIKSSAYTLIEQSHERKLVNYSTLFLTKNTEAYVILKNVLEQLDSLESIVLHFHPTNEKDIERIAINNDQLNEDITKAVNAIVNEFITENINNASRKNRKTVEAYIKHVIELKDYILNKMLSRITELSTWENKEVLKVVAEGNTSIRQLINDNMNMLTNLIKQIISNLSDEGLGNVKEMISSVNKDFLQKILPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS88</accession>
    <name>L7JS88_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2706"/>
    <dbReference type="HOGENOM" id="CLU_2783033_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS88"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="69" mass="8010" checksum="1F0D6FC66FDEF2F0" modified="2013-03-06" version="1" fragment="single">VLCDILRLTSMVRRIKLRFWPCRTCLLGELCRTSMNRRPVAMVKALADQEKGFIIFAVNNGEVGRIYCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSD3</accession>
    <name>L7JSD3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994046">
        <property type="protein sequence ID" value="ELQ74339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2747"/>
    <dbReference type="HOGENOM" id="CLU_2706558_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSD3"/>
    <dbReference type="OrthoDB" id="8093043at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="7553" checksum="81C45BBBF24D2660" modified="2013-03-06" version="1">MSVVHDRPESGAWPLTTSGVTFGLSPGSSETPAGVPGQVRKAQEGRVKNRSVMPLDGLGCTRTTVVAEMAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSJ1</accession>
    <name>L7JSJ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2632"/>
    <dbReference type="HOGENOM" id="CLU_138075_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSJ1"/>
    <dbReference type="OMA" id="IKYYFNE"/>
    <dbReference type="OrthoDB" id="2190490at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="156" mass="18741" checksum="581827E149C0AC61" modified="2013-03-06" version="1">MFTLPMILVIDVYDVPAAKIIQFIYDTKMFREIEQRNDASDDESNAIFQYLNKMRTREPTNFFVRGESFSKRVLDKIKYYFDEICEVQGTILRITDRKKREIRFYDIVRDEREIINFVRIKDDLREQADELGTSRTIKPYLDAQEDEVVLFPSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSU5</accession>
    <name>L7JSU5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2738"/>
    <dbReference type="HOGENOM" id="CLU_2203404_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSU5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="12667" checksum="E63370DB4BFD24C3" modified="2013-03-06" version="1" fragment="single">VKTNKSARCFIAIPIETFCKKTMPPINYFVCDYQYIFDNQKFILEKVHHGQDDIIWPTFDIDFKNHIHELQLNVSKSLDSVLSIKVKFNTSLSFREKCCVSEDYSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSU6</accession>
    <name>L7JSU6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994104">
        <property type="protein sequence ID" value="ELQ73812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3274"/>
    <dbReference type="HOGENOM" id="CLU_2177193_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSU6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="12267" checksum="53BA1D3DF16A10B7" modified="2013-03-06" version="1" fragment="single">VSDQNPLCAAADQDRPLVSNTLVSRASYSRALIPCSEDTSGTKCRKTILPIQDDEQACHAGTDRFKRFRNDTFACQQIADSIERTLLPTKMSALRTQRPPYKTYNEQGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSW2</accession>
    <name>L7JSW2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994037">
        <property type="protein sequence ID" value="ELQ74519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2563"/>
    <dbReference type="HOGENOM" id="CLU_1943274_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSW2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="130" mass="14288" checksum="E84332B30E51A502" modified="2013-03-06" version="1" fragment="single">VCEGASEREDGESLQGGAILQPTGVRVDRKKPMRVDRFVTYKLGSFTGANHELFAFLVTNMRIDEIVDGEADRVAELLFADVKAAVMQVRRMDSNLSYGLQGAGRSLGRGRREGTSLADDPEDEERPSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTC4</accession>
    <name>L7JTC4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo/beta-Catenin/plakoglobin</fullName>
            <ecNumber evidence="2">2.7.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JH994088">
        <property type="protein sequence ID" value="ELQ74012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTC4"/>
    <dbReference type="STRING" id="72359.L7JTC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3078"/>
    <dbReference type="HOGENOM" id="CLU_059424_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTC4"/>
    <dbReference type="OMA" id="NICKNRM"/>
    <dbReference type="OrthoDB" id="2195084at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="287" mass="32971" checksum="CDB9BC453659F7AA" modified="2013-03-06" version="1">MKEKKNAATNEVIAMVKRRLNNRIKVIAIHGASTSGKTTFANNLYASLKEHMPTFLLHMDSYYKSFTDTDVTKYDFDNPSSVDWDKIHGVLRSIHDGDEFIPTYQYSFVSRKSTGPIMVRNNSPEVLIIEGIYALNLFNRIVFDTNAFDSYDSSKEGYKENENEYPDFGVLKIRLNICKNRMEHTRVCRDVLERDRGYLESTLQFSTQVWPATTRWVHSSVFKSNIDLVHGSFNTSNYKTLFKCITDCLTGNSLYLAELTNEFDVVDCSKECVNKSNSDLTLYDSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTN2</accession>
    <name>L7JTN2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994074">
        <property type="protein sequence ID" value="ELQ74117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2969"/>
    <dbReference type="HOGENOM" id="CLU_3070362_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTN2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="53" mass="5860" checksum="E984143DFA380A5C" modified="2013-03-06" version="1">MCTPPLFLNYKNNVLLYNHVGGNVKDASLPEVKVCRITIGELMNQSFKCSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTP4</accession>
    <name>L7JTP4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994072">
        <property type="protein sequence ID" value="ELQ74127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2955"/>
    <dbReference type="HOGENOM" id="CLU_062891_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTP4"/>
    <dbReference type="OMA" id="CEIERCK"/>
    <dbReference type="OrthoDB" id="10470025at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="274" mass="31977" checksum="45F4BF2526DFFD28" modified="2013-03-06" version="1" fragment="single">VSRDHNNLLIKDMERMNAAEECHKPVVKKELFDKWTDMNSFKAPDMPMINKLDNDVSVQHGVITSDRAINDAVNRDKNGIPDQKGHGFIASYTHVRMKNNININRISPLKYFLLLNDNDSEENRINQIIRMSLDYLSEQESSFKDLDLRIELKDRAQDKIREVECEIERCKSEIEKWEEIGQEYVANCLKEGIRLKEKNTTLKHEENDKNDNAVLVEQNKERIAKLALMMNKYIEACKNGCEEIYRKMFAMVKGSDLDPLLVLKTLAKLKRMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTU9</accession>
    <name>L7JTU9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2931"/>
    <dbReference type="HOGENOM" id="CLU_403426_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTU9"/>
    <dbReference type="OMA" id="RCINTEH"/>
    <dbReference type="OrthoDB" id="10573135at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="654" mass="75174" checksum="FC3EF1C8BFAEF75C" modified="2013-03-06" version="1">MEVKHDHPKKFSADEQKRTNDHHRHINNQNANKTAANDQYDELKTTKTVNKHVKHEYKRMQRINALHKNAAMRCNSVFMHGNAVLRFTARSAVLVVYHLLVHVFVMPCISLSYFLVTAVLVKLAVHCVRLERIGKDRYLMDEYLCVIKGGDVICKGVVGMVVYVLYTFYEDYRALFFFSGYDERSDVERGCFSGGNSYGDGLEEKSDLYRKGVFNGEATSERNISDEVNASNESLNENLNERSTANENPNGRNTAKEKNKVKHTKQYANQKRKTNQKCKTNEERKNNPHRNTTLHKMQRFMQSMNKKMHKIITRQNNRTFYTALICNLKDDVIDALRFLHLPYFTGRLVLFILSYPKMMNIIRRINIFDGIERAPLIMHVLSYVIGSLITCNTGVLLVLSINALNVLIISAYTGIINTIVYNVALFTVDNAWLRHAFNFACVVLFRHGFLNFNVLCMIDFIAHEIKDEDMNERLMENIKHVYALMRSIKERIHTTCDEQQSTGTDNESVSDRSNDQYEQKSSIDNFLTAIDTLKGNYTIDSIKDNNADAPPQQPYSTIYASHKHLNVIMPCVRYVPLLLLVTTALTVLHRTNLLTLSNALFTISTFLFLNMMHKVNVKCFLAFALFVIAGMRMSTSVCIIYLVLRIKKGLLSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTX3</accession>
    <name>L7JTX3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetraspanin family integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTX3"/>
    <dbReference type="STRING" id="72359.L7JTX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2915"/>
    <dbReference type="HOGENOM" id="CLU_121525_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTX3"/>
    <dbReference type="OMA" id="QREHVQT"/>
    <dbReference type="OrthoDB" id="2192630at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="226" mass="25959" checksum="F3D6688A43DE78DF" modified="2013-03-06" version="1">MKGKETIKKGLMILFIVVQSLFLVFSILLIVLLITLYSKLRSYLMLSVKPLLISLSISSLYVLLPVIGILIIVRHRITYTFLYIVMVLLLMNFDILLVSMEYNMVKNTPGYTDKAWDKLSNEQREHVQTKLGCCGFRDRNDRSVGDCENVGCRDVFLGIVEGVKNKSERFLIGVFALKSLSLALVAMMSMRKKRNKHKNRRKTDKKSGGTSDRKVSVEPAKWFWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTX8</accession>
    <name>L7JTX8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTX8"/>
    <dbReference type="STRING" id="72359.L7JTX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2316"/>
    <dbReference type="HOGENOM" id="CLU_891981_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTX8"/>
    <dbReference type="OMA" id="KRILCHI"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="312" mass="37056" checksum="F2E390999A98E8DD" modified="2013-03-06" version="1">MTESFINEAELLLFTRNTARLIKKLMDMHFKGKVSKEQLKEKLLLLKESLKKKFAALEQNDGLKPIDNLDYAIQEYLEQNDIYIYEQRIPYFEKLKQKEENIRKNDLEELQIFCEANKVLLKELKSDLMENLKVRIFIIHCCNKEYSEAIQFVRAKQISVDIMREWLFLLVRDYNLHMSKINEHLNNLVNEYKRILCHIKGLPSQTRLTNRIVAGIIALNSIDCLNKRRVDDCPTCLPWIQSLAAKLPYSRRTNTFLRCKGSNEEINESNRPLVYETRHIYSEKYLKTCGYVVYCAETKKYCDKKPEICFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU19</accession>
    <name>L7JU19_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein involved in plasmid maintenance/nuclear protein involved in lipid metabolism</fullName>
            <ecNumber evidence="4">3.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU19"/>
    <dbReference type="STRING" id="72359.L7JU19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2165"/>
    <dbReference type="HOGENOM" id="CLU_002546_4_0_1"/>
    <dbReference type="InParanoid" id="L7JU19"/>
    <dbReference type="OMA" id="RDGSICE"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="3">
        <location>
            <begin position="530"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="726" mass="82653" checksum="3377E860406D96EF" modified="2013-03-06" version="1" fragment="single">VVKDRQGELRSTKFYVCFDQSHFNSSVYLIVNGVVTDIVMEVDEMGHCFFQVDYEGGDGVVDGKNGGNEFGSVNKDLSKMEKTINYCNVGINGTGKDGDHGKDRSASEKGMTNKNGVDSKSSANQILNTTNKSSANKILNTTSKSSANKILEITNQAENNQLAIKTGTAKNTSSMDDAMLALHKKIQMRMNENNILEDNQCANNALDFKLEDEEKCIMTDSEDDLRLLRRRTANPHFLSQNFKLSSSKLIVNKFLKESEIARTTNLIYRTYAMRYLKNRETFYERGGDVLGEFLKSKEHYDYLEESAERLFLIMARRLGTDRCTSTDNADAGAPDMRINGFAGKKGSFNAAHETGGDASGTRECACTKAYTNRVITYHSPYLLYGRKTGSDRAAGNFKFSVKYSLCADKKIAFSIEKLFTDHSVKNYVHSPNLVVRLSDGHVSFYMPSELFAELFMFCLDDRASFTKFKEFMREKMGRKNVHKRRTRNLSSHDLHKLHLQCGRNTLEYKLAGVDRRIEVSVYLWNESDKVIVSDIDGTITKSDLWGHIYDLVGKDWTHGGVAALFTKIVNNNYRIIYLSNRAMPMYFRTRRYLSKIKQNGCTLPDGPIVLSPKSVLSSLYTEVRNQSHIFKIDCLQQIERLFCGRRPFFAGFGNRISDLLSYKVLGIAKSMIFIIDRDGSICEGMKRKVSASYLTLNHFANTIFPEIKKEEDKKKKMYHDFYFWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU99</accession>
    <name>L7JU99_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2530"/>
    <dbReference type="HOGENOM" id="CLU_3387204_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU99"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="33" mass="3465" checksum="4D09F160A3519270" modified="2013-03-06" version="1" fragment="single">VFLAVKATLSITRAVEQYGTLLVATLRLGGLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUF0</accession>
    <name>L7JUF0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA mismatch repair protein-MLH2/PMS1/Pms2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUF0"/>
    <dbReference type="FunCoup" id="L7JUF0">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2437"/>
    <dbReference type="HOGENOM" id="CLU_004131_0_2_1"/>
    <dbReference type="InParanoid" id="L7JUF0"/>
    <dbReference type="OMA" id="YICQYNQ"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="2">
        <location>
            <begin position="441"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="609" mass="69830" checksum="CC0A967D037E72B5" modified="2013-03-06" version="1">MSCIPVCGCYQVTNASFPPKHVHNGQAQAQHMPIKRLSADTVKILQAQKYVFDYTKILKELVENSLDAKATRIIISISKDIEVCDNGTGMVSEIDYFKTNKETELVLSGTLTDYYGYKGIFLSSVRDICDLVIITKTKEEKLARCIDYKRGTVEKVAREDGTTVRISNLFKNSPIRRGALKLKVSEILRMLEDFLVFQAVFVRLVVNNRKVFERHGTELPQFVLENNLRAVCSQSFDFFYNLDRFKNPLILAGKRIITNKKLVKRLKTTLSLFFKDKIFYVLQLKNIQIDILSIDKLEVLLDDDLIDDVISTLELKFSDTRLFEQSNKMFNGSSREIFESSQKPEKEVKIHKKLRTNAAETENKTLIWGDTLVNVFRPSTIEMRGEIMNDTVEIPFKTNSGDDKENVPAENLAIYDIFERMDVNVDKEIEVQKSDLKNVKIIGQFNQGFILATLNGYLMIFDQHAVDEIYNFEMIKKGIKFNKQSLLKPISLPSDSMLMSDDLSSPNRLDQAMLSSLNRSFEVKDDKITASPSFNKHLFNINDYRELVSTGEVSSLTNKIASKACRMSIMIGDKLNLCTMNRIIYNLSELDNPWNCPHGRPTFRVLYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUH6</accession>
    <name>L7JUH6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2645"/>
    <dbReference type="HOGENOM" id="CLU_3193995_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUH6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5268" checksum="9421BB01096C8AE7" modified="2013-03-06" version="1" fragment="single">VIQVALEHLNDWFISSPIVVQLAFHFRKVRVLNFAAHMATQSMQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUJ7</accession>
    <name>L7JUJ7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUJ7"/>
    <dbReference type="FunCoup" id="L7JUJ7">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2671"/>
    <dbReference type="HOGENOM" id="CLU_080773_2_0_1"/>
    <dbReference type="InParanoid" id="L7JUJ7"/>
    <dbReference type="OMA" id="CIFAKND"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="170" mass="19811" checksum="FE698B18C0565593" modified="2013-03-06" version="1">MNPYKEYKVYGSKLPSSQAPSPQIYVMQVFAKNEVTARSTFFRVLRKQHKVKSTNGCILKMVPVVEQITHVKPYGIRFTYKSKKGTHNMYKEFRGVSRVDVVNDMYNDMAGRHSVGRTAIDIVSVKELNDDEIRRENMKVLGNPEIEFPVFKKCLARQEHFVEEGEKYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUM5</accession>
    <name>L7JUM5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1883"/>
    <dbReference type="HOGENOM" id="CLU_1120786_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUM5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="248" mass="28473" checksum="7AB99732DA177731" modified="2013-03-06" version="1">MNFLEYLVLECKRRLLSTYSSTNNILQEPQAAQMNCNVYQNENAFRREMSMVFLMFSVMFIIWFLLMYFCLTKTPYQQPDTHSEQEYVVEIGENNSLMSLNSNQENNARPQSEASVDGHHVDSPLSYDRNNDEDLYEEIPSTESSSFSVFSDDTRSFDTDSQITPEYTLLPSPFLDIELLLFVHNLLDRTSSSTSADDDNAQITSPRIQLIDSNVSQLDIELNLFLNLQMDSDDLPSNSSSLEVINTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUM9</accession>
    <name>L7JUM9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative WD40 repeat, subgroup, WD40/YVTN repeat-like-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUM9"/>
    <dbReference type="STRING" id="72359.L7JUM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2334"/>
    <dbReference type="HOGENOM" id="CLU_417496_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUM9"/>
    <dbReference type="OMA" id="PNCEGAV"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="657" mass="75588" checksum="90ECF3BAD84C1A6E" modified="2013-03-06" version="1">MERDKFSEIIDLMNRTLNEDNNNIYSLTKENVEEALKELFKKQKSPMEYLRSFKYRNVERQLLRYRTLHHHRICARRIGDVSAFYNFGSDRRNEHVPPAAAARPANLKEYFLPAPVVQYYLVKSMKEHDTAITTIFIERTNRYFLSGDEGGCIKLFNLRTGNLIREFFLHFGGINDINFSHCGTYMISSDSGGCVKINDLLTEKTVVHQFNSSILLVEALEDGMIVLESSGILHKIDKTGRTYINNIIPNCEGAVGAVCISEGANILLVGGSFPFLLLFNLKNFKNEAVILDTEGYTISYVCASRRRTIFMCSSFYNYLFYFEFNVGKGTSNYKKNNNTYFWKKCRIQVDLDEYDYTEKIIFLNDDRYFITTATDNKLRVFKNREMIRTLNNVNGNLLAHPVFNVFLVFNYEIKIYDVWLNVLQHIKLDFFITEISFSDDGYTFIVSDELGNIYMYSLFPTLSKSSLGEYVVKETSIPVNDVEIACLESLEVYSMDISKIKKKYFYEERREDKKSESTASEISEDYTEDLGTDYSSHFEDGSDLSTGSDDKSIKEIRTAGNRARHSAINVITDDNYEIPIRRGRRIISDDSDSLSIVTKKKTKARPRKKTKKVNDDSTDSCCKNRTVKKSKTASEITSEHEGDTTTFSDLSSLSDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUP7</accession>
    <name>L7JUP7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2312"/>
    <dbReference type="HOGENOM" id="CLU_3034054_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUP7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="6464" checksum="B472115529A2D898" modified="2013-03-06" version="1">MFAHILLHLVHLWAKDGDEKEDESGGMTPVYVLGFFLFLFVAFFIFLVIFSKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUR2</accession>
    <name>L7JUR2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_1989</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUR2"/>
    <dbReference type="STRING" id="72359.L7JUR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1989"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="L7JUR2"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 8 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="12">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="12">
        <location>
            <begin position="254"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="490"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="579"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="10">
        <location>
            <begin position="725"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="11">
        <location>
            <begin position="1179"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="858"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="874"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ75060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1263" mass="142727" checksum="0B54E4559C25D324" modified="2013-03-06" version="1">MNLIKSFLKQNGLFRHHLTSYNHFITTDLKNILKVNNTILSDIDPSFHMKMSNIRVNKPNIIDNMVVRDVLPEECRLRDLSYLGDIVVDVEYCVCRKINVRKDVVIGKMPVMVGSILCHLGSAGEDEEMGWMKECILDGNGNIVNDNDGIVDEMKDGRIVQNETDNTVKEDIMNEKRNVAIADDTFLTEEMHGAVKDSLIEGGFTENGADSTKKRAVSGLRTKKRNETQMNSTISRDIAQMKRLFVTKRPAYRRECPLDEGAYFIIKGVERAILIQEQLSKNRIIVTNETSTVSSFTSERKSRTTVIRKNNNYFVKNNVFTEDVPLIVLLKNYGVEEHEIVSLGCSLNDLRIDVHAYLKSVCKGREGFMDEIVLPNVKREVKGFYLLTMARLIERKGTFSDLDFLGNKRFELSGSLLCLLFEDALKRFNEEIKKGIDKILSKRMRAQEFQPLSLISLNNTITNTLCRAISTGNWNIGRFRMERSGVSTALSRLSYLNTVNTLTRVVSQFEKTRKIAGPRSLHTSCFGVLCPCDTPEGESCGLVKTLSMLTEITVDVPFDEKVFLVLGVAMGNFKNKFLVFLNGCPVGSCNECIVERLVRMRRAGTIDKYVSVSRTDTFVFVSTDGGRICRPLLVNPYVNADNNELGGKAAVNSASDTNHSTRFARFLQRTVYNEYMSMHDLVHKGVVEYLDINEQCNALISLRHRYSTKHTHYELHPITMLSYSATTIPFPEHNQSPRNTYQCAMGKQSMGIACFNYKQRFDNVLFINYYVQRPVTYGDYVPEVLSGQNVMVAVMSLSGYDIEDAIVLNRNSLDRGMARVTVYKSYSVGIGRYGDGSSDVIMPFKECDGDVCQGQGVEKKRKSVKDATSNTKGRGNDDWDKNKRMNDETEEKNTEMEMYGEEERQNDKEMKNKRENYNEGARKCNHNPTNSTSSNLTMNDGIRCVGEIVKNDILINKYSPKGVFNGLFHKKLAIVDTVVITDTLIKIKMRETRTPVIGDKFSSRHGQKGVVGRIIRAVDLPFNERGIVPDLIMNPHGFPSRMTLGKIKEVVAGKVGVLLGRRMECSAYSFNEYDDKCSVADNGDDIDSDGDKYFTCNDKKTLKTIEDYCMVLQSLGYSYSGKETFYSGMTGKPIPTHVFFGPVYYQRLKHMVEDKIHARNIGKRTVLTRQPTEGRSREGGLRVGEMERDCLVGHGAAEMLRDRLLFSSDAVDVGVCDRCYVVKDRGGACCGRVVDVKMPYACKLLFVELMAMGIYPRIKIGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUT4</accession>
    <name>L7JUT4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2444"/>
    <dbReference type="HOGENOM" id="CLU_601586_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUT4"/>
    <dbReference type="OMA" id="THNEYRF"/>
    <dbReference type="OrthoDB" id="10432749at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979162" evidence="1">
        <location>
            <begin position="20"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="459" mass="51034" checksum="7FD686EDF3DCA5BA" modified="2013-03-06" version="1">MNFFSTLFAIFPIVSLKQSNPVMTEKDRESVIMDYEAMKIIRSESSQLKDVKLGQDYKPFNPAATIAAVQRLVSNMAQVEQNYVKQSAAALQKGISEEIDRFEKVVTQTITTQLDAIPKTELDGITALVTDLGNKLVGYLNSYFQTSDKDFVSDIDTLKKCLKIIKGTSKTSKGNQTPAECVQALVKNHAASEQKSRSTLNNLIKQALAAAPKSSIVDNLIAKIKQLAITAENAIFAALSLTEKNLSDFSTRTFTNMLQFNSLKQKDLQKDLATTLETMLKNLYVKGEPPKKYNFKQKGLIMLDEYSLPAEAALPNTSWLKFEMKGTMSFENGKATMAYEKFTINGNQALFNKLYPRFTFKSNGQIILWEEGTKEKDAIPFEGYSFRSYGTITLKTLSAGHNNVMGATNTSVSYDGYRFDSDGQIILSKNTFAQDNARGIKVPIDIWTSFTSAGVISFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUT6</accession>
    <name>L7JUT6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA cytosine-5-methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUT6"/>
    <dbReference type="STRING" id="72359.L7JUT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1889"/>
    <dbReference type="HOGENOM" id="CLU_385511_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUT6"/>
    <dbReference type="OMA" id="GNDMFEM"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="263"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="717" mass="81956" checksum="408A1253449562DF" modified="2013-03-06" version="1">MQNKHLIPYYTTILDLSPRDMQQFIDMMDRPLPYVIRVCKSTPYYENVVKIVERMGFKRMCDNVYVLENEGESVVENEGEGMVGKGRDSVVENERGSVVENERESVVGKGGGGKGSMTGEEREGVTENEKNEENEMEDALDKKKEENGKEGVLDKERESVLDNDKEEKHEITNTENETTNKETINIKNTKENETTNKENTKDKNEQPSQPNNHCITPPLIKKYLTILTDLNLITRQELVSILPSSFLITLKTRKGALQVLDLCAAPGSKSTHMLENNITLTANDVSLKRCFVVQHRSAHMPKLLTNANGLSFPRPAVPYDAVLVDAPCSGDGTFRKNRVVVGDKNVRLMRALVIKALSMVGDGYVVYSTCAVDPVENEWVVQSVRDECEVVSVDEVGNDMFEMVRMDCNDRNGCDRNGYDRNGCNDGRDNCDRNGSCDNIPNPNIPNTKTKINYFNSNDRHVNGKYKIFYREGLTEWTTPTEYKSENYHELKKCMRFYPQDNNSGAFFIAILRRRKKNGVKGEDVKVEDAKIENTRVKDVKIEHNKVSSHNLTPHHTSNENTTVLTMNGTKYSYASPTLIHTLLSHYKLILKGHFITTPNTNRIYYINNNDQLNVANKTNVVSIGILLFTKIRDDQYRMNNLWYFGRYVRECVVVDEMMLRRMIDGERVDELRGKGLCVVRCRTWYYCVCGGRDRVDVYVKDKEKEIIRVMMGDAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV03</accession>
    <name>L7JV03_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994011">
        <property type="protein sequence ID" value="ELQ74871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2193"/>
    <dbReference type="HOGENOM" id="CLU_1100721_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV03"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="253" mass="29472" checksum="1619AC9B8E6F8324" modified="2013-03-06" version="1" fragment="single">MTCYIRSNMNYGVSTFNLDINEMEKKGQLRLCEATIHENVKINKDLETVDFSNVVVASQSVVVLNSECKNLLITRSEGLFDLREHIGAVQLFNLKMVINVTYQRGHFYNVGRLSLLHFCFKETAKLSNIYQWIELNNISTTKNTELIINRACKELLIYDCNMVINIHEVEYLEVLRIFFEFDVENRIKFTGSKRVNHINFFNICLNNSIISILEDFEEIKYVEFDNSISDAVETSINNYFCKLMAFLTSKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV29</accession>
    <name>L7JV29_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_2532</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV29"/>
    <dbReference type="FunCoup" id="L7JV29">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2532"/>
    <dbReference type="HOGENOM" id="CLU_025086_2_1_1"/>
    <dbReference type="InParanoid" id="L7JV29"/>
    <dbReference type="OMA" id="QMHEKGG"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="97"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ74617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="245" mass="28541" checksum="F19881EE63DCB5D6" modified="2013-03-06" version="1">MPTSRYVESSFWNFDALFQPQNHPAREMHDTFFLANPEKTRLTPTSYSERVKDIHEASYKCEWNPEESLKNVLRTHTTACSARMLYEIGQNKDNLHPIKLFSIDRVFRNESVDATHLAEFHQIEGLVLGKNLSLGHLMGTLQGFYEKLNLKNIKFKPAFNPYTEPSLEIFAFHEKMNKWIEIGNSGIFRPEVLEPMGIKDDWRVIAWGLSLERPAMIKYNLDNIRDLLGSKVSLEFIKDSSMCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV47</accession>
    <name>L7JV47_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV47"/>
    <dbReference type="STRING" id="72359.L7JV47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1791"/>
    <dbReference type="HOGENOM" id="CLU_377312_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV47"/>
    <dbReference type="OMA" id="YNIFAPS"/>
    <dbReference type="OrthoDB" id="10400714at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="374"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="489"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="729" mass="85467" checksum="142FC5544E0DD8E6" modified="2013-03-06" version="1">MYDLYANFPELLSFKPEIEGLSSSARDMIKKVVLTVHRRTNYYHFNYEKVKEENRNLWIQINNLKNENIRLLSKIEAVKRDGSAGLDDKHGDIRNEDAVAVPCGNGKTGNDRNAEYFTDEECIYDKGQDRVMIVTNDNEQDGNIEVKDVLGAQADNTCRSKRNEQGVSTNKRVSIGESNDSIHNKSIENNFLDSRASQDEGSFNTSFFSNPLTVINLQNTIYQLNRENNLLKEKNERLCREISFVLDDGMVNRAKKTVDQYVNDYYDVVGLLKNMCRLNDSLKNENIKVKASLILERKDRENMVSEHKKTLSEQIARLTRENTELVIVNERLSNELASAMDRCKLFERSNEECLNKCRFMEVENYDLKFKNNIYEGLERKLDEKNFELQTYEYRLGEKDKEIERLRERLKDKDDKIHSMLVKKPFRQVVLDYKQVFGELRENARGMTIKIREILALVEKMDEMSKTERANMRSIAESKEKLAAMYKDKADESLNRMERSDEQLRRCNERIRIMTVEIENLKKDEADAINKLNEVHEENANLKTKIDGLLVQKNTFVKNNQSQIMKLLEIERRENEKELQKYKKIAEDVDLGKIVNVKTLMKQLEESKNAVSSLENEKKNVNERFNQERARIEEYYTQELQNARAAIEDLNAKQQIYVTGFEKIRELLQNSLNTQVCDFEQLREVIVGLTERCNKLDDELKTKERSIENFKGIILKLRSVNEKMLKKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV62</accession>
    <name>L7JV62_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hly III (Hly III) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV62"/>
    <dbReference type="FunCoup" id="L7JV62">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1901"/>
    <dbReference type="HOGENOM" id="CLU_051078_2_2_1"/>
    <dbReference type="InParanoid" id="L7JV62"/>
    <dbReference type="OMA" id="RIHQIAF"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="208" mass="23908" checksum="EE59C74A16AD2806" modified="2013-03-06" version="1">MQQKPILRGRIHQIAFIISFVSLILYLVYSLFTNLHSGTLIILTTQCILYGTSSFYHLTSFKHTRTERFAQRLDHMCIFLFIASVHSSMALTLKLMYTKLILTTTWMIFILGATKIFLTEKIIESIDVVLYIVHGLSILIFLRFESLRSVYRMVLPLGGLLYVVGGIVFGLEKPDLVPTVYGYHELFHTLTVLANICFLIPIIMFYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV88</accession>
    <name>L7JV88_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2100"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV88"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="871" mass="98870" checksum="6B7A24512C1142F8" modified="2013-03-06" version="1" fragment="single">VKNKHESYQDFIKTNSTDTSFIIVDVPVTISLFQKILVLTKNNVPKFTFDEIYDIMSILFPFKDMEGLLAYAVCLYLEENPNVLKKLRQCHVAQDKSAFHDKIVFLSTLILDQNGGQDSFIEIVCRNIWFGSCHGCEFYDTSVSNIIPNKIIHHTLKLEDSSIIFLFKYINMSYEFLEGNIDLLNHKFCEDTLHKAFTVRVHSISYDDDETNQSALSENDVLERKINLLATCELLKCRGFERVILEFENFSIPIESNTLTFIPALGTISCVNCTRDFINSLPQDVKNVEVVFSKTHDLNIRYLLENVTYVRFLNAEFDGNIAFIHNKAEIVILSSIIKEGATITFPSECSKVYIRNTSGIFNMSGIAGFKMITTGIYNKFESYFYKGSDSLVIQNIMLDISAVYLTSIGTLYLEFVIIPKQSFCVVPDGIKSLKILRSVGLFNLSPYIGTSIRIQSITSIVIEPPSDKNSKLSSIHLSDITIDREVELADKYETVILTNVSVIPQVSLILNDKCRNLTCSGYIGNITVGKGKQFDVIKINCTGCPPLEIRFSNQISVRHLHLHHLGQDMSAFGALLSNFEKIERFEISDGYISPYIPEFYSFSGNVSMFSPHNLSENASKELSPYKDSKSNVGDSSHPEELTCKVTPIAWASANAKISETILELDFRNTSATKEDWGLLQNLSHLKIVRACVDNVHNESLIQIPSNIRLLELINSINRKNVFQVQNQAEWLNPLTTFHSLRILIVEFDIFITVCKHDLLPPRLETIMVYFVSDIAKHSAINQRVRVRELLIGSKSNGAIPWFMTMNWSETLHFINVLTNYVDFKSLEHLAVVSPGDLLALNPANYLIEKDQSITTKFLYLEQIMRHSQQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV95</accession>
    <name>L7JV95_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="5"/>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV95"/>
    <dbReference type="FunCoup" id="L7JV95">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1651"/>
    <dbReference type="HOGENOM" id="CLU_1115529_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV95"/>
    <dbReference type="OMA" id="QRNFMVF"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="78"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="213"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="297" mass="34570" checksum="8E6BA8A9469A25DA" modified="2013-03-06" version="1">MTGKTNEDDLSKLTQEQARNTEDKCQTDQNTPKEAEDRNIASIYAKNPKYYSIFGRLLHYLENENYGAIITELTNLYFDDQLPMTEYDIYCTTPYTNEVSLTYDLPYRINASFIRTEFVTYIACQRPKVKYYQKFVEFANHASDLIVCLCNDQEDYFTGSTCSSTADEGAGTTVQTDKQDTNKDERVYVIEQINNTKRIKFLRWEDFDVPNREDFAQFYDAYVSMDKSDKPVIVHCKAGVGRTGTFILYDVLVRMKNVTKEVFIDELCKMREQRNFMVFNGAQLKWLANIFLGNGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVA6</accession>
    <name>L7JVA6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993999">
        <property type="protein sequence ID" value="ELQ74986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2070"/>
    <dbReference type="HOGENOM" id="CLU_2905763_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVA6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7624" checksum="B5F5ECBCE0C570DF" modified="2013-03-06" version="1">MANDYQALRKFAFKFKFKRKGYKMDQNLIDICDELVIRYAKVRKKLKKYRIRYDPEKTSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVJ5</accession>
    <name>L7JVJ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1706"/>
    <dbReference type="HOGENOM" id="CLU_790327_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVJ5"/>
    <dbReference type="OMA" id="HETTERK"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="351" mass="40820" checksum="D0361787CDCC4356" modified="2013-03-06" version="1">MKYSVIFVLVILSNEVHMDHSFHTNIIRTTSESFVERMRSNEQVNADKVRKDIQKSPCYSSENICAGKTLDCDALASKIENNMTRENELSRTDGVNLIVNERLSTSKRLQDHPRTSADKAVRTILENNLLEVEKRSRDENSGIGCNEIKNDESLRERTPNIQNCLFQHSTDNTMHNKFFKDFNEKQQLERANKTKGQARIKMFYFYSSSSDSDDQGLTHVTCSHKERPSRDEDARDRSRCLKYDIYMLKIFVNITTYNLKAYVSRTTEGLYAVRSLVVILEQFRYFLHDVSKRNDKTEIIPVKHSLVHKLRSSFPSSFRKIMEMLYGISDSRRICSSIARLIEQISSVRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVK5</accession>
    <name>L7JVK5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2005"/>
    <dbReference type="HOGENOM" id="CLU_3147361_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVK5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="6002" checksum="B8E3254286220175" modified="2013-03-06" version="1" fragment="single">VNKLWLIKRDKKDEQYRGKKELLKKIDHLPKVPRRRTLSMGMRETLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVL9</accession>
    <name>L7JVL9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993951">
        <property type="protein sequence ID" value="ELQ75528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1519"/>
    <dbReference type="HOGENOM" id="CLU_2185772_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVL9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="12468" checksum="14D83386848EF013" modified="2013-03-06" version="1">MTRVCTHPTSTLELNETIGEFSINSCIDHVNFDGAHYFEMIELGISVHVFDDSEQNLHFKKIDAERTGSLFLSNLEVNETIHFGPDIEKLELCDVTVSEMNYIIINENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVM2</accession>
    <name>L7JVM2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVM2"/>
    <dbReference type="FunCoup" id="L7JVM2">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1736"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="InParanoid" id="L7JVM2"/>
    <dbReference type="OMA" id="TWLTGKH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="164" mass="18246" checksum="50DA05F404979D65" modified="2013-03-06" version="1">MAAKLPVCYLKVRKDKEPLGTIKIELRSDVVPKTAENFRALCTGEKGYGYKNCSFHRIIAGFMIQGGDFTNNNGTGGRSIYGPKFDDENFELKHDSEGVVSMANAGPHTNGSQFFITVARTAWLDNKHVVFGRVVEGMDVVKNISEMRQDTNDYPVIIYDCGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVN3</accession>
    <name>L7JVN3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2274"/>
    <dbReference type="HOGENOM" id="CLU_1714609_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVN3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="153" mass="18051" checksum="E66BA5C5D4AE18EB" modified="2013-03-06" version="1">MRSLAENCAVYLVTMLFNILDFCENKLKSRICLNRNIIRISGVDGITIGCTHEKCLKSEILTTLIKKILAKGMKIKMWLFYTLLIKKIRHDLMKTKNVEVNDKKREVRQYKVQKKVYRKKPPRVVNNIGLIGRASKKLKKWYALCDFRWITKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVN4</accession>
    <name>L7JVN4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophosphatidic acid acyltransferase LPAAT</fullName>
            <ecNumber evidence="3">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.1.51" evidence="3"/>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVN4"/>
    <dbReference type="STRING" id="72359.L7JVN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1528"/>
    <dbReference type="HOGENOM" id="CLU_041844_6_1_1"/>
    <dbReference type="InParanoid" id="L7JVN4"/>
    <dbReference type="OMA" id="HRSTVDW"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="113"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="318" mass="37458" checksum="48742823FB624C23" modified="2013-03-06" version="1" fragment="single">VPVQPALHNYFCCPAIIIHSKLCTLYYHMLGLLGLLKILLKLLLIPVHIFIFLTFIMYGVFLIPFYFLNYKWCIKLTTVYSFIIWHLYRASLYLTAQVLVRGSIASIKRDENVLVISNHIGAIDFLMYHEVANMKGMIAHCKYILKRSLGYVPILGPSLRCLCFCFVDRCARKDVESIRKYVDYVHRNGIKHWLMLYPEGTRFTQRKKREADEYCGQKGVPPFTHVLCPRTKGFKVFHEHARHVYKNIVDITVDYRNADGERAVCSLYKFFTVEIDGTFLMDVRVVPMEEVHDCEQFMDECFRRKDRILSEWRGTKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVN5</accession>
    <name>L7JVN5_TRAHO</name>
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        <submittedName>
            <fullName evidence="3">Anaphase-promoting complex (APC), Cdc23 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ75543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="72359.L7JVN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1501"/>
    <dbReference type="HOGENOM" id="CLU_018320_5_0_1"/>
    <dbReference type="InParanoid" id="L7JVN5"/>
    <dbReference type="OMA" id="LIAHEYM"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="514" mass="60054" checksum="7E958F2F56FE0F7E" modified="2013-03-06" version="1">MSFYSHAQFNTLSHLEKLSINIPQSLTAQEIPLLVQFHLKNYYMLYQGVHCRPDKQFYFCTCHSTRDNFLRNYALLLHKNTIKESVNVSLEPYVENEFILYVCALLESDRSRKEDLLMNAVTVNGLFVDAWQELMGVLEDRNRIVKIGSAKTGDEKLVWEVVKVELYCRRFIDLGIDENVLFKVGDWRKSEMSTDEHRMGHKSQLIDHETNDSCVTNTNYRVRDDMNHISNEQSVNPPVDTHTRLFSPIISNSVSGCHPDLNTPYLRNLSAAYFYHKKEYDLSLALFNTSTLIDYYDLYSNILYIKNDKRALSLLCHSMHSKYPFSVETMATAGNFYSLQKDHTAAIHHFKRAVRFNHRYAFLNTLIAHEYMELNQYNTAIKYYSLSANDYRAYFGMGQAYAMQSSRLAIAFFKKALLLNSTDPFIWQSLGHEYKKFGDIANALECYRRMVECGEVSGWLMIGDMYKNRKEYKHAVEYYEKYVGVVKDEKISKYLREYHGRLRECKEGGDEDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVT7</accession>
    <name>L7JVT7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1613"/>
    <dbReference type="HOGENOM" id="CLU_3399655_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVT7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="31" mass="3392" checksum="56CCAD4D81C8CDD5" modified="2013-03-06" version="1">MTRMYHILIFVLGTNHASINETSGVGVLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVV0</accession>
    <name>L7JVV0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1419"/>
    <dbReference type="HOGENOM" id="CLU_1504498_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVV0"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="179" mass="21204" checksum="93E22778AE814349" modified="2013-03-06" version="1">MMTISVFDKDFTLLYGNPNLNVQGLMKARSREIAYLEKQDHILVGHSKELEVPVMLSVLDKIRVDYLNDYYRFFTYMDNKFFNGYVLDEDCKPKSDKYQVFKKERVKFDVEEKIRAILQDNGTVLCLYAQGRITCCPQFITNTQLYIQYSIPKTEIEMRYSVEKIFGNRQTQGNKYIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW30</accession>
    <name>L7JW30_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2101"/>
    <dbReference type="HOGENOM" id="CLU_3193994_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW30"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5237" checksum="3CED308BC1E004F1" modified="2013-03-06" version="1" fragment="single">VNEHARQLLLPFKKVLTEKTSNEHNASLELSCIHRIHDIPSTIVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW35</accession>
    <name>L7JW35_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994002">
        <property type="protein sequence ID" value="ELQ74972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2090"/>
    <dbReference type="HOGENOM" id="CLU_923066_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW35"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="302" mass="34152" checksum="553D2D3937A17BEC" modified="2013-03-06" version="1" fragment="single">VDYDVTIKEKIVSSKMSGVVFENGHMFTLRKESHIISIEKSTGIFNLFKKINLVIDPANRAGCKFFLQTIDNYEEPNIISAFVSLSISTSFLSTITNISFIRVKFIGPILLEINNDIKKLNIEKCNGTIKTSGIVNGTLSSLQNFVSEIVVVKVKNEPKYDLKIAGYIIPETLTIYCILKNLMLENVYNSNMSCFRVVNTCEYMELNNYFGIVEMDTGPCLKSAVFNHAICIYSEATGMLDLKDGGLRLDTYFLPRTIRHLRLKGLVMNVSEVFHLHDILENIEICNCFGLFNFKNVFNIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW97</accession>
    <name>L7JW97_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Heat shock protein DnaJ, Molecular chaperone, heat shock protein, Hsp40, DnaJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW97"/>
    <dbReference type="FunCoup" id="L7JW97">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1458"/>
    <dbReference type="HOGENOM" id="CLU_1409723_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW97"/>
    <dbReference type="OMA" id="HPDRCKL"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="193" mass="22559" checksum="1A892A80526D32F2" modified="2013-03-06" version="1">MTTNNGLGGFGAESQTTRRVVPNKDDIQKKIDNILRETDSYAILDIKRGASDGEIKKAFHKLSLLVHPDRCKLKNSEAAFKKVLNAKDYLLDRDARAHTRFRTHAQPNADTFSYTNRFYESGPGFYHFYYAYNDNNFFDVLNNRFERRAYYSPFYGDSSHRNAQSFRPVHYNPDAYKFVLFILLLFIVLLNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWC4</accession>
    <name>L7JWC4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWC4"/>
    <dbReference type="STRING" id="72359.L7JWC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2032"/>
    <dbReference type="HOGENOM" id="CLU_091940_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWC4"/>
    <dbReference type="OMA" id="RFIKERC"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="265" mass="31562" checksum="89E78098B495794A" modified="2013-03-06" version="1" fragment="single">MMQYKLVLTKSDSASRSLLLVPVDLKKLNEPLHLKREEKAEQPETETYKNTKKKSETIEYVDEKYKKLSEEESQPLILEDTEGRGFKGRLQTVENTQNNYFVFINTGKAFKVIPVSKWYKFTQRINYDTLTLEEAESKMGKDDDRWMMHKKKEEEVEEIDYEEVFDDDDGEEAHVTGYEEKKQLSTSGKELKKFLRSLEESEERDDKGQKEEKKEMMKLSEGDLVQMIMNEEMSIKELLSRIKLRFKIDEYTKKLVQRFIKERCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWD6</accession>
    <name>L7JWD6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1391"/>
    <dbReference type="HOGENOM" id="CLU_2869240_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWD6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="64" mass="7870" checksum="D00B114F32463F49" modified="2013-03-06" version="1">MYAERKRKRFQKEEVTFDEASRQAFLNSYKGNKKKKGKSTRESRTNKRRRRMDRRKELLGRMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWE7</accession>
    <name>L7JWE7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993930">
        <property type="protein sequence ID" value="ELQ75734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWE7"/>
    <dbReference type="STRING" id="72359.L7JWE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1303"/>
    <dbReference type="HOGENOM" id="CLU_071105_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWE7"/>
    <dbReference type="OMA" id="DACNFRY"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="333" mass="38112" checksum="8AEDD43BD416C90E" modified="2013-03-06" version="1" fragment="single">VHIPPMISKVGFLTEGIEVNMLNKYIITDSDMESLRESLCETPNVLEESCSSDYDDEKIFKDDIVLYCTVYDFQMESSYLEFHVYSKDSELFLHHDVCVFADIYDACNFRYNNEDYVALALGSNKIEVYSFMIRNPLQPVFSLNKHTSTVSGITCSNGNIFSCGYDQYVNKWDIETRKVKAEKYFNERLDSIENHTSDLSMISSTNGFILDHDLNITATVDAKNLTGLKIIGNRIISTDTEGLIVERDRRNIRKSVNVKKVHSLGINDFDIQNDRILTASDDETICVLNNNFDVLKSIKTKNKVFTLNIYPNNRPNMLFAYGGLDEIVNVHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWH7</accession>
    <name>L7JWH7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1936"/>
    <dbReference type="HOGENOM" id="CLU_1788170_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWH7"/>
    <dbReference type="OMA" id="TDEVIFI"/>
    <dbReference type="OrthoDB" id="10366711at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16860" checksum="AAC4E861FB29AC7D" modified="2013-03-06" version="1">MSELLEDDSLAQWKEFFESNMEEGKKYFLVQNFYSKDSFHFSDSDKKCTAKDAMLYASLLSSDDLSSGVTFNDHNYAFIKKLEYGSGDNLPLFFFLSKDEVIGKDKERVNLIVKFITDEVLFIGKCLNSKRPAAIHFVEEYYNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWK8</accession>
    <name>L7JWK8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_1342</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWK8"/>
    <dbReference type="STRING" id="72359.L7JWK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1342"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="L7JWK8"/>
    <dbReference type="OMA" id="IMDYCTS"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ75670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="317" mass="36762" checksum="257586453E2D3D78" modified="2013-03-06" version="1">MQGPTMDTSGDEIETELRLPHAYKLIRKIGEGTYGTVYLCEFNSQRYALKKIRNISGGDGLPLVVVREIKILKMVDHPNIIKLVDIKVVESECNNLLGKAVFLVFYYVENDLLQLTMNKQFNENEIRKIIGQILQGVKFLHSNNIMHRDLKTNNILIDRNLDVKIADFGLSKHIKNGDSAYFDDNDIVDETYTSNNLTTNVVTLWYRAPEILLDENYSYKIDIWSIGCILMEVTLNRNVMKGRNENDQLKKIKHVLARLGGYFAGRSRNLYELGNGLLAYFEEERFCAKEALECRFFKEEEQKEIKKHNNVRKKQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWN8</accession>
    <name>L7JWN8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Centractin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Actin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Actin-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_1377</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWN8"/>
    <dbReference type="FunCoup" id="L7JWN8">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1377"/>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="InParanoid" id="L7JWN8"/>
    <dbReference type="OMA" id="PNIMVGM"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ75705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="377" mass="41800" checksum="70E0254ECE7ADE08" modified="2013-03-06" version="1">MSSENAPAIVIDNGSGMCKAGFAGDDSPRSVFPCIVGTPRHQGVMVGMGQKDSYVGDEAQSKRGILSLKYPIEHGIVLDWGAMEKIWHHTFYNELRVAPEEHPVLMTEAPINPKVNRERMLQIAFETFNVPSFYVSIQAVLSLYASGRTTGLVLDSGDGVTHIVPIYEGYSLPHAMMRLDFAGRDVTDYFIKLLKESGYSLVTTAEREIARDCKEKTCYVAVDFANELERYENAEKEIVKTYELPDGNVLKLGNQVFRAPEMLFSPSLSGFELPGIHETIYNSIMRCDVDIRKCLYSNIVLSGGTTMYPGISDRLQKEVSALAPPSIQVKVIAPPERKYSVWIGGSILASLSTFQTMWITKDEYAGIGPSVVHSKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWP0</accession>
    <name>L7JWP0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CorA Metal Ion Transporter (MIT) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWP0"/>
    <dbReference type="STRING" id="72359.L7JWP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1143"/>
    <dbReference type="HOGENOM" id="CLU_030291_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWP0"/>
    <dbReference type="OMA" id="ETRNANE"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="538" mass="63137" checksum="AB2344B46ACC106B" modified="2013-03-06" version="1" fragment="single">VQITYKSERAWTGSKQRILEQRFLLGGPVHVIKRKKGMPIMASNSRNIAEIITIYRRMKKGRENQRVYRQMLNVMNEDENNERVDEYEMVVDTRAQTGTTAGTNATHTGNASGNVHRDEDSTLSTNPACVPGKDTNEQFLRSYETGNYWDDKNKDEGDSEGYNDRPSGRNGGVSLIGERQSNKFYNFERYQDVEQAKFLFYSKEAGMFQTDSFSEIETRAKGYYWLSIFDPAEKDLIDIGRYFKVHDITLNDIREKNTKEKVELFHNYTFISTRLFSERETRNANENEKIKSVDIDFNILMFRNFIVTLHDTRWNSISDILNFLNLISEYTTVYPEWVLFSIVVEFLQDVRFLLELIVPEVTAMQNNSYVVMDEIGGVLKENFLLTNSLFSLRTSTKPKIHILNNIINKYGRKLRRSVLKHIYFTYQDFLSLDKEMKENSKSLERCQDLFLALVNMEQSREGNEMNKVMKRFTIITFIFLPMQTVAGLWGMNVPVPFQDETKLWPFFLLCIVGPLISMVYFFTPRRLFHLFQNRHHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX61</accession>
    <name>L7JX61_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VAMP-associated protein involved in inositol metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX61"/>
    <dbReference type="STRING" id="72359.L7JX61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1407"/>
    <dbReference type="HOGENOM" id="CLU_130507_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX61"/>
    <dbReference type="OMA" id="GAYKIRT"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MSP" evidence="6">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="17441" checksum="0B430F3E65B89183" modified="2013-03-06" version="1">MNDSSIMILPSKYVTIDNTTRKGTITLQNNVLSGGAYKIRTTSPKDYSVRPNIGIIKPLQTITINVILQSECTSKNHKFMVEVYDFDYKKSVDEFKKVLREGNLKAVCTKILFVEDKQVSKPVVTEDNEFIYQCCTAVVVAVLFFYAVKNLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX73</accession>
    <name>L7JX73_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Homeodomain-like, Homeodomain-related, Homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993905">
        <property type="protein sequence ID" value="ELQ75905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1128"/>
    <dbReference type="HOGENOM" id="CLU_173461_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX73"/>
    <dbReference type="OMA" id="CKGLHAL"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051306">
        <property type="entry name" value="Homeobox_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46123">
        <property type="entry name" value="MIX-TYPE HOMEOBOX GENE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46123:SF4">
        <property type="entry name" value="MIX-TYPE HOMEOBOX GENE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="111" mass="13111" checksum="21282159A8F0ABFE" modified="2013-03-06" version="1">MDDENLQKSFETKKRNRTVMTGAQAKILKNYFQKNMFPSTEAREELAKILGMRPRTIQIWFQNQRQKTKSRYGFDRQHHEDDAVECKGLHALAEIASGLLDRNKDKSRIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXA8</accession>
    <name>L7JXA8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0979"/>
    <dbReference type="HOGENOM" id="CLU_109007_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXA8"/>
    <dbReference type="OMA" id="KEVEYPR"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="222" mass="25657" checksum="C3732CE70A3C94F9" modified="2013-03-06" version="1">MSPSMLLPQIMQILGNIVFVFAPCIGFIPQIVKRKITFAPILSTIVILANVMKLLYWQSEHFPLEIVLQSIFLVLFHFVLLYLSKQELSILEEKLVLNRFTEKSYRRYGMFSLIFSLTVSVVLMIATIGLIFRTRYVYTIFGPLFLVAECSVGLVQLLIIETESKYSLGKEVEYPRELFLMWALGDILKLIWTIKLNPPVFLIVSVVFQILVDVAVVFRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXD9</accession>
    <name>L7JXD9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXD9"/>
    <dbReference type="STRING" id="72359.L7JXD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1363"/>
    <dbReference type="HOGENOM" id="CLU_088999_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXD9"/>
    <dbReference type="OMA" id="CALICEK"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="2">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="227" mass="26583" checksum="CAA88B318F08D1F4" modified="2013-03-06" version="1">MGNIFSKKLSLREQLFNLDERIEKRSQKIYYLRKQKSYYSFVVGIIYLFLLPLSAVFLHFYEFSFLFLGLPILSFVLIQTTVYLVFTKFIDYNENLLKRMKKTQLEQIEQLKRDVDYIETLKIVQKYDKTAKTKKQSSAESVVSTQSLADKLTNIILGDNPQQMCALICEKCFAHNGLVFPIQFFNRKFKCISCGTLNITKCEDELLEKKENDVDNSIPDESMINQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXE4</accession>
    <name>L7JXE4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1368"/>
    <dbReference type="HOGENOM" id="CLU_1016349_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXE4"/>
    <dbReference type="OMA" id="YWFRTER"/>
    <dbReference type="OrthoDB" id="10565433at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="289" mass="31790" checksum="4E773EFD4009E4AF" modified="2013-03-06" version="1">MSDDGDTKKTSRLVGYIALGLSVVLYLGLVAITYFVMADTFIFHAWWWSLGTGVGIVAIIAVIFLLKGLIGMIVNTLLFIVVLLLIFAQYWFRSERVLVLGSIDDAAENFGASDADALGTELLKDHPRRIFVFIGKMAAGGGAGAKSKQGSKTTEEGEEEPNASEPEGQGEPEAPEPESQPKKQGKTEITEEAVKKALESETKKASEAKEKVHVVQLADNLKYEPGKKESAKNIVKAFKKFSFARHLDQGVLRFEDDVEYGKAFEEGEGTKEGMNVKDFSEKYKKKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXJ9</accession>
    <name>L7JXJ9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JH993886">
        <property type="protein sequence ID" value="ELQ76050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXJ9"/>
    <dbReference type="FunCoup" id="L7JXJ9">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0984"/>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_1"/>
    <dbReference type="InParanoid" id="L7JXJ9"/>
    <dbReference type="OMA" id="HHRSWVV"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="28"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="330" mass="36262" checksum="9A63CAF6DAB7B71E" modified="2013-03-06" version="1">MLILGIESSANKLGIGLIQDDKILFNKRVTHVTQAGTGFIPSETALHHVRHILPLLSKCIVDTGIKLSDLDLIAYTKGPGMASPLQVGAIVARTLALYLNKPIIPVNHCVAHIEMGIKITKAKNPIILYASGGNTQVIAFSGKYKIFGETLDIAVGNCLDRFARLAKISNDPSPGRNIELLAKKSQKYLYLPYTVKGMDMSMTGIISFIASKYNLDKKETVQALCYSLQETIFSALVEVTERAMALTNSYEIMIVGGVGCNERLQAMMETMAKERGATLYAMDDSYCVDNGAMIAHTGMLMHQSNQSFTLEQCDVVQRFRTDTVSVTWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXK9</accession>
    <name>L7JXK9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0832"/>
    <dbReference type="HOGENOM" id="CLU_1176128_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXK9"/>
    <dbReference type="OMA" id="CIAKKIW"/>
    <dbReference type="OrthoDB" id="10341455at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="236" mass="28258" checksum="3E22D0D2A0DFDAD4" modified="2013-03-06" version="1">MMRKENEVMRRKSFTRIDERYESNKYIEYGAREWNNSRGYGHSGYGANIYAMDGTLAINSYEMRAKTQKSVYYSRKEGSYRIPRLDNCWENNRSHEKNYASFNFSSNVLNIPKNRSNLPYTLFTLTNTALQHRILAKLFISPPQTFFQFTPFVLIIATIYIRRHSYHTGMYNNFMNFFFIGCCIAKKIWNDKVCKVESWMKMDERSALECYFCKNVNYDFIVSEREFGWWTVMLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXM0</accession>
    <name>L7JXM0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0842"/>
    <dbReference type="HOGENOM" id="CLU_746363_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXM0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031540">
        <property type="entry name" value="DUF5088"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17008">
        <property type="entry name" value="DUF5088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="371" mass="42785" checksum="249CFDA63291394B" modified="2013-03-06" version="1">MVFIIQSIHRYHSVQKSGLTCHFDVTLKKDDQYLTYKLSPCAYDNVVKGKHRIGDEVFIRDGDEGVAIENEGKQDDSSTVTDRYLVRSERIDEIEMNDDSKMSYLPFLSDTPLFFKTVPQRINAFYREGALYFDGMIKYEMIKNEHKNRRKTSFEQGKPTLNATSSPNRGGEVLFLPFVAKIVLKSRIIAYNHGSFPFYQVLVVVDLTENKLVTVVLWNRSVYKYCNLQHNDIVIIPRCRKKKRYYNNGVMVYNSYSDVWMFDCEEFSVNGNDDICVCDIRKVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXM4</accession>
    <name>L7JXM4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative SNase-like domain protein</fullName>
            <ecNumber evidence="7">3.1.31.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.31.1" evidence="7"/>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXM4"/>
    <dbReference type="FunCoup" id="L7JXM4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1262"/>
    <dbReference type="HOGENOM" id="CLU_046484_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXM4"/>
    <dbReference type="OMA" id="PWLANGD"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990599">
        <property type="term" value="F:3' overhang single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="204" mass="23770" checksum="337D50F1DA7CCCDC" modified="2013-03-06" version="1">MYTLLLIAFIALPLLIAISALAKLLHKRFRPIQTNKQFKLNHTIHAIVTKVCDGDTIRVRHRPTWSCMRTTKRTILVRLYGIDAPECAHFGMPAQPYSKESTALLRKYVMGKKVYVTKLGTDRYDRCIGRVVVDGVDVSVMMVRMGMACVYVGYNAIYGRWYDKLVRCEKRAKKRALGMWKEGVELPMDYKRRMRNRNRRRVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXP9</accession>
    <name>L7JXP9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993863">
        <property type="protein sequence ID" value="ELQ76179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0853"/>
    <dbReference type="HOGENOM" id="CLU_420460_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXP9"/>
    <dbReference type="OMA" id="RFKKPYD"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Cys residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="652" mass="73939" checksum="B76D34CEEC787FD7" modified="2013-03-06" version="1">MRTKNPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEDKNSKPNNTKPSDDTNKKNKQNLEKKKKNDEDDRNIELVPDDNRNQGKQREQNRPDSPPSQQEADANYPESSLNELKLDEDELQPQTKDKEPKPANEESVDDSNDQAKESPNSAQKASSSNPETSNKPKKSPRPESQDKSSASKNYDNDEKPRNEEQQNKSPASKSYDNDDKSRNEEQLMPPKQSNRDEPEPSNDQEPDDPQAPNQPSNPGNMGNQPKNRRQQNPQDTSENPSRSDESSPRDDDGQVPNPYTSNQKKSPSSQVQPQTPQNDEPNNPQDQSQNPSSSNPQKSSPQNKPPGREEDTPILKKSSELGEKPLNDSAKPGKKNVPESHSNNPGSNGKQPGENDGQNNRENNEPEKLKRQPELGASNTNTENGTEEVKGEEGLLSENGTKRKTKKIEKDNVEKDKEYEDKEDEDKDDEDKEDEDKDDEDKEDEDKEDEDKDDDDKENEDKDDDDKDDEDKEDEDKEDEDKDDEDKEDEDKEDEDKEDEDKEDEDKDDEDKDDEDKEDEDKEDEDEEDEDKENQDKEDEDKEQPGDDTITLSDADSENPPKKTKNKNKRKKKGPGKGKSPSSCKCNCCSHGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXR6</accession>
    <name>L7JXR6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993917">
        <property type="protein sequence ID" value="ELQ75846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1198"/>
    <dbReference type="HOGENOM" id="CLU_3399654_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXR6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="31" mass="3549" checksum="371E628C13713522" modified="2013-03-06" version="1">MRRKEMKVGTFLMMDGERVDNGCTTDEQNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXS3</accession>
    <name>L7JXS3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1490"/>
    <dbReference type="HOGENOM" id="CLU_2832980_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXS3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7931" checksum="99CF4864880A62CB" modified="2013-03-06" version="1">MKEYFKKSIERLYVYIKKHQFVECLPDMDDILKKCDELDGDTATMRLGLSEIYMMIQECLIKFSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXS8</accession>
    <name>L7JXS8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0825"/>
    <dbReference type="HOGENOM" id="CLU_1618990_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXS8"/>
    <dbReference type="OMA" id="EHYTITI"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="152" mass="17820" checksum="65D71567C7DC1EBD" modified="2013-03-06" version="1">MLIYKLFSNPIKEKILKSPYFKEIKNYDLDQTISDAHKLSSIGSLVYGSPHPFICLLQKLESLNVDNNTMLEKYHGALREENSTVIMFFVFYFRMTAKMKNEFNEIKKPLENKKLLVKIVDENNESYSVTIKEVLNMLQSNKYVFGIFMKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXW5</accession>
    <name>L7JXW5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear distribution protein NUDC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXW5"/>
    <dbReference type="FunCoup" id="L7JXW5">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0753"/>
    <dbReference type="HOGENOM" id="CLU_124011_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXW5"/>
    <dbReference type="OMA" id="RFIIVEF"/>
    <dbReference type="OrthoDB" id="2190447at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="163" mass="18635" checksum="F43A72EBB58F1F03" modified="2013-03-06" version="1">MSNENFKWDQEYDEVQVMVPYSEDITKDDVKVELTRTTFKLCLKGVVVLSGELSNPIKSDSKDILFYIDDGQVVVTLEKESRKWWDSFFLGGEKVDINDVASKKQTKFEDLDPEAQSLVEKMMHQQKNKMEDGVTDGDIKTAELFNELKKGGKLDLGSDEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY18</accession>
    <name>L7JY18_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate transport-inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_107279_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY18"/>
    <dbReference type="OMA" id="NGMKRWT"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="255" mass="30246" checksum="34BC58370991CC8D" modified="2013-03-06" version="1" fragment="single">VLPNKVFFYKYRIFYKFLYSCINCGTKPYIMKFIRGYIHSYNEASLIVHAVRLGIIEPIKERLSNSDRENIRSGCVFVFIEDDSGIKRWTDGKIWSPSKILGHFLLYKEVPKHLSKSAIKKRNANTIKRERVISIHTQMQNDEFSLFKKTISIKHESKSYHIISYFQPIFDKRGILEFPFFKSLNSTLVNYPDLMSDHHVEALKLRNVNLYTKYNLLKFEKGNILPEIDRNAMERMACYILSNRLRVDRSVCRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY19</accession>
    <name>L7JY19_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1413"/>
    <dbReference type="HOGENOM" id="CLU_218125_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY19"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5022" checksum="17E4DC1D149CB56B" modified="2013-03-06" version="1">MLKGMLNCMFSKLYITKMHGAVLILSMCTFKVMNKEVVDLLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY26</accession>
    <name>L7JY26_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY26"/>
    <dbReference type="STRING" id="72359.L7JY26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0646"/>
    <dbReference type="HOGENOM" id="CLU_915826_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY26"/>
    <dbReference type="OMA" id="GQPKEDM"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="253"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="304" mass="34492" checksum="746D194E40AE6882" modified="2013-03-06" version="1">MKISLNFRSTKYSLEVDENEKIGAARERFFDMIKDAHSDVNINDLKFVGMAKFLDNEKTFSEEGIKPDSTILVHKALPKKEKDSKKDVKTSTSTGTAMPPFSNMNVPPVDAFGGINSSVINNQMNLLLNDPETLDLTIKTIMPTATNEERELYKKTFVENCRRFKDNPELLKQMTSQMQGMVGNNNVNPYMPASPAMNPYSPVMPNYNIQPPPYNPYYINPYAQQYPMPSPTVPCFHGFYPLNYSLPGQPKEDMEKRFEVQLKTLNEMGYTNKQHNLQALAQTGGDVNDAVNLLLDWLAGQRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY53</accession>
    <name>L7JY53_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-directed DNA polymerase, LTR Retrotransposon</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JH993890">
        <property type="protein sequence ID" value="ELQ75991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1043"/>
    <dbReference type="HOGENOM" id="CLU_3070361_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY53"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="53" mass="6354" checksum="3F88B3362678A06A" modified="2013-03-06" version="1">MKKVQYARQEVKLLGVTINRRDKIPNEMKKNEAFEFLKPYKITQLRRYLGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY72</accession>
    <name>L7JY72_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY72"/>
    <dbReference type="STRING" id="72359.L7JY72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0760"/>
    <dbReference type="HOGENOM" id="CLU_010289_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY72"/>
    <dbReference type="OMA" id="NYALYWA"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="237" mass="27623" checksum="93E4AC6E5023AAF2" modified="2013-03-06" version="1">MKRFVGLISGGKDSFYTIELLKQKEYNLVALVYIKSTDIDSYMYQTVGHEMIPFYRQVLDVPIYIIETNRKAINTDKEYVHTLNDEVEVIYDHLYELQKKAVFECVSVGAIKSYYQYNRIKSVCDRLNLSVLTPLFNLDQRVIYDAIIECMDVVIVKVACTNLGKEIVGKNLNVISGMRVDNWCGEGGEYETAVLDAPFFKKKLRIKNYEVLHHPEEEDKERTVFFMKINEIEVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY90</accession>
    <name>L7JY90_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1359"/>
    <dbReference type="HOGENOM" id="CLU_1251508_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY90"/>
    <dbReference type="OMA" id="TEPINCK"/>
    <dbReference type="OrthoDB" id="2196367at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="220" mass="25218" checksum="46520F1FE38F1A82" modified="2013-03-06" version="1">MSIAKNRFEKLFNFYFPHLSYHLNRSTEPINCKLVFLDLEIEIDDEYEDCDQCETAVFELGEKILSKYIEDLSQHQDADASNDASVVNTNAKNDNSTGDNGEKTKNSGSNDGNVEAVKKMEDAIKKKNSKSVENSMQSNTSLQSQCADFYAKQVHTLCICYSLPFPEYHFLKEDGLYRCYTLYANKNYESEYFYEKNDAKEFVCKAIADIIKNSVVDVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYD4</accession>
    <name>L7JYD4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0696"/>
    <dbReference type="HOGENOM" id="CLU_1631130_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYD4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="163" mass="19410" checksum="7E7B99332873268D" modified="2013-03-06" version="1" fragment="single">VLLYWITLYMELLSGFMCVILVQEDLKYLLEQLEDNVECYSVLINEINHRLYEAHHRGKGCPFDSDILVDLAFTINEFITEYKSEDAFWSKRGVVIGKYAHIYDSWFLESLSSFTVDDLDWCTDAMEKLVQNKIDSKFRNRRSTWMIIKKKRVLKYIENKAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYD6</accession>
    <name>L7JYD6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0553"/>
    <dbReference type="HOGENOM" id="CLU_1344082_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYD6"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="204" mass="23848" checksum="A97D85EAE4939BCD" modified="2013-03-06" version="1">MLKYNSKSLNKKVRKAVYLGIEMNLKNCTDKDRAWAVYEVLIKLGEKDPDIEGRSVCKRILLGRKPDMASKNFSLGQTAGFSAAKKEIKTNFPFLQRVPVRTNNVQEPCVKTEEVRDSFKSYLKRHNDEMKKLFSEKIAFNKVVNTPPKKQVRGVDQLKRKAEVEQRPQNILEYTPRGLNKYLEQYREEVQRLKVSPINEAWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYF3</accession>
    <name>L7JYF3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993877">
        <property type="protein sequence ID" value="ELQ76081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0944"/>
    <dbReference type="HOGENOM" id="CLU_710155_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYF3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979134" evidence="1">
        <location>
            <begin position="22"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="389" mass="45394" checksum="56F3906C1D789D01" modified="2013-03-06" version="1">MRDLMLLIIIFLNTCMSTGRTDELNRVFLTHGDVINQFVEDLSFFTHLLNEKSEIFSAIELYNSQRLRRDDYTNLQNLLYIIGRKQCKLTSLDTRPSNECYTNLNSIFIKILMKINGNAVFRQIFHVDATTIRYVMNCITEKYMKCAVLYYDNVALTRHKTSLIDFLNVLSGKLISTLTQCDGFQCLRNVSPKAFQTRVENFSTISFINAYSCITKALVICYNLESEMENTVMASTIDDTDQSENMAFISTELRNLADFIQHLESSQTKHDGYHNYATIFLQLGTHLRPCSKIICSFFSLGTSMLLTFQPTIPHFTSICRSLSNYFYQLHQMKMHQELYMDDEIMRVIIEKFLKEGIATVDVMLKFFNSFYTTMEKLRLYRIHYNRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYI3</accession>
    <name>L7JYI3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-related protein-Arp5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYI3"/>
    <dbReference type="STRING" id="72359.L7JYI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1258"/>
    <dbReference type="HOGENOM" id="CLU_447027_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYI3"/>
    <dbReference type="OMA" id="YPFTEHV"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="611" mass="69973" checksum="3DF1901ECE1E76E2" modified="2013-03-06" version="1">MTVVIDNGTHTIKYGIAGTRPRTKENVLYKSKHNYSFTPSKDSYIKKMFVNNIPVNYDVLEGMLDCVFSELGITKVHDIVLTLGVCTPKVVKREIAELLIEVYNVHKLQLGIDSVYSYLHNVKQRNACDIVVSSSHSETHLVRMDRLDDVMALPYGGERARAYYNALLRPKNIRKTDFYVRVAQDYRREALAIYDRLRNRDLKGSYVLEERKSVEKAENMKMNVRKALEKKRLRRKEMEEGDICEEDEEIEEGNGEKDEENGEEDEENGEKDEENEEVEEDSNVHESGIDEENGNEEENEGENSNEVDNENGNAYADEEENGDDNNSALDLDEGASHVPQVNGPSLKKNRMVYYSAIYRNKQKIEKCLLAMRDSLTQLEERHFKMSEPEKYLQSIKERFFVVRARIEAKENLKRKLRNKRSRESALLSRATNMNENEQMFTQDEAQIIEQINEIDHEDSASEQKCSKLLNEIYALDPSFEFLDFSTVEIMNGDHMGLTLSNTESLRVGEAVFNPSIMNCALPGLSEMIESALQGIGRAHGSVNVFVTGGFSQIEGFFERVVAECTMNAYGGVKCIKANDPVLDAFYGASFCEYFPVISREMYREEGPERLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYL3</accession>
    <name>L7JYL3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993838">
        <property type="protein sequence ID" value="ELQ76553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0465"/>
    <dbReference type="HOGENOM" id="CLU_391371_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYL3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="705" mass="81752" checksum="97ADEF017694226E" modified="2013-03-06" version="1">MPVYKKTKKMHLTTEITEVDGSATCSISGLSSIADDCSILPNDWDCSELLRDNILGTGENDTNESNSGTKIDPWLDDLLNSYPITGLTEMMTEIDNDCWSYNSDLLSVTSADDMVIDADANLRTVDSTDDCDEQLLSFVLDYTEKTAEQKGSEPPGVQECSNIPAKRSCKSTEAPEFVKEQPNDDSKTKETKLKKVKATDEGSTNPDSMIELKVPEHTMLEENTVPCINLEAVSKCGIPIFDESFVNFLRNAFEFTFCSSVICNIFIPLGTARDKILTYQTTTIGLQYILSSTLVNVAEILRKSNYSKLYCLKRRRDNKLNVFMTFITTVQMESLDGSGISQSATDLFRREPEWERDELPKLLNKLKIISVTNNLRKNISSKIIFMILEDEIEPCLIFTGRKTYRNSIEYDIRFYIQVLDLLYDHMPKPLDVKTQYSVRFCKQHLKNLARYFLRILREELKDLKMKLLPELFSLQDELYRKPGVFLYMKSNHILIIIYSVSNLHRMLRYIDRRIYHDQNNISARDNHQVLSLVLFMRELLLVPFLMSLSCHAYVVSTYLWLCKTENLFLVTNDILYVNPTNTRINPFSTAFFYFFFVAHFYEFPARLFKLGDLRNTKNVEYLMSQLSRFCTPYFIAYNVPRELYPLRPISPATFDQIYDSFSFKSYNELYVSICTLINHWKFRPCNEILFFIKQMVFCTHIAPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYP7</accession>
    <name>L7JYP7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993837">
        <property type="protein sequence ID" value="ELQ76559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0453"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYP7"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="963" mass="110734" checksum="BFA1CA984C5649B4" modified="2013-03-06" version="1">MSVNLHSYIEIALKYILIFKTPAYAQMSDYMVFEDLEQTGMKSLLETYMLNTIAETSYDTSECNAEHHIKKMRLVSECANYNTIYVSKDFYGKNIIGKSYQDIIREEGDTKFKLINVPFSMAIFTKIYLLENKDDPVFTNEELCTVFFHIFPHVKRISKLTKAICFHLQNNPLFIQELHIIAYDLEEGNHGEEKKLLSTLLTCTSDQAKVFREMVNSMVTFSLRDKKKRVAKTNEKIARYGDIFYDIKLEELNIAFLLENLIMSYDYFVSNHGVLYEKFGNSLAKLSLSIKIRDIHDRNDDMKLDLFLETRILNHKINFITESRLLKDGNIHKISLQFDGVQIPLEKGALSDLKKLSTIVCDSTSFVFVESASKEIEKLEVSLKDKILGSTLCIPHNVKKISFSKSQFCRNITFPNHLDSIEIMNSKADQDVIIIFDESCENVTMENTQTKIKFLEFAALNYILLKCEESGCSDVHYRNDKNSENGYLRISNSELSGEFYLNEGFRKVIFVRVNLTFGSKVVFCGQNKSLKISGSTGLFDLKYLIGSCLSLTRNSEIEIRPIENSLQNFSILFIKNVEMSECLVLPDYFENVELENVSLTNNMKVLLNRTSKTIILKNFKGIIDFTDAVCLETAKIHFGNEQKNDIIFHGMINTHHLCLINVVVDLNAVQSILFSLGSVKHLKFEVTDVYNINIEECIRVLKSFPRHQERAVYFDNLRKNPLSYCTFSNSLFQETTNATINSIIEGLGCVPVSKTLQNIEFESAKFFENSYSVLRHLENLRILDLGTQYITDVLFNHLPPKIRLLNITGLNKQKGNGLIKYNLCELQKLTNFSNLKVLTINAELLLSSCTLVFMPLSVDVLKIHFDSEPSKHKTPLCVKRHLRELIIKKPGHWEDVREAQPFVDILQHYIDFRSLEQLIFVRSYSLVKVNPHTLELIEARSGEFFERVGSLRGELEIDGPLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYQ1</accession>
    <name>L7JYQ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNARE protein YKT6, synaptobrevin/VAMP syperfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993908">
        <property type="protein sequence ID" value="ELQ75877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYQ1"/>
    <dbReference type="FunCoup" id="L7JYQ1">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1154"/>
    <dbReference type="HOGENOM" id="CLU_074848_1_0_1"/>
    <dbReference type="InParanoid" id="L7JYQ1"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="246" mass="28696" checksum="C1780269C20A8AEC" modified="2013-03-06" version="1">MLSFPNIPPNHSFLSLSPTITHIISQQLFVIPPNHYYQLLRCRPQPSIITSLRLTTLYSITHPMLISLSSIETDTLKIRNEAFNLGQFNFLQRIKIKDYMRTIFLKISQNVQTHDLQEITQELNGKMYKFYVKVHADIVYIACIQDYYPLDLIDTVLDKCAYSHAEGNEDLNKLLEEYKDYKLHDTTEKIAKELEDTKVILTRTLESVVLRGEKLGELTDSAKKLEIKSKKLFEKAKEQNKCCKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYW7</accession>
    <name>L7JYW7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0543"/>
    <dbReference type="HOGENOM" id="CLU_1778764_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYW7"/>
    <dbReference type="OMA" id="MNDMRID"/>
    <dbReference type="OrthoDB" id="10347767at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="17153" checksum="10635DA2211A0B4E" modified="2013-03-06" version="1">MNPFIASLLYASSILLIIIVHFIPPHIAQKTQENVQKQLKTQFNELYDTGAMNTHTGYYLKLKKVVRYSHLLHEHDVRTLFAYSEMNDMRIDAILNSLEFEKGNVFTFYLPPLFNFGIWFPLLCPILINMVVVLKTFIRRCKCVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ33</accession>
    <name>L7JZ33_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0756"/>
    <dbReference type="HOGENOM" id="CLU_3020136_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ33"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6472" checksum="5A8933AAB9F9A499" modified="2013-03-06" version="1" fragment="single">VSLSNVNFVDDNATQIFNSYKKVVMFVACKLRLLVLKNLLALNYSKICMNTEYLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ95</accession>
    <name>L7JZ95_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Histones H3 and H4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_0212</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ95"/>
    <dbReference type="FunCoup" id="L7JZ95">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0212"/>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="InParanoid" id="L7JZ95"/>
    <dbReference type="OMA" id="ANDCAIH"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000096">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ76773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="139" mass="15721" checksum="BF36DB3882AFF75F" modified="2013-03-06" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAMQTSSQGVKKLRYKSGMVALKEIRRYQKSTETVVRKAPFQRMVRDVTSKIRDDMRYQAQCLSALHEAFENYLVGLFEDGLLAANHAKRVTVMPRDINLVGKLRGRFGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZB5</accession>
    <name>L7JZB5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0937</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZB5"/>
    <dbReference type="FunCoup" id="L7JZB5">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0937"/>
    <dbReference type="HOGENOM" id="CLU_041825_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZB5"/>
    <dbReference type="OMA" id="INIMCER"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012677879" description="Phosphotransferase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="223"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="444" mass="50909" checksum="D735178A760F27A5" modified="2013-03-06" version="1">MRLFAILFFAACSLGLPDLESEFLHSDDMLTNLSIDYWREMMDNFAAGANRQHFLDTYVKVSDHSTITYDKEMLVIDFGGSFLKCGIYALEGKTVKPIHPIEQYPLPKRWRNSTKRADCFEWMAFHIDYFLRSKNYCKALRAGMTFSHPVNQTSIRSGTILSLGKDFPFKNIDITKENDPVKLLNKELQKRKVPVVVDVLLNDATATLASILFTGDRQETFSIGIILGTGTNAAYVDHIFCKKPRIINTEWASFDSLNLNVTPCDERIEEMVKEEGKVYKRLDCMVGGYQFANLINIMCERENITKRLKLDDILRIVEECETKSFISDQEMFICKCYEVLKKRNAQILVTLVLSLIKSQAVQPSTMVEIAINGSQFSNPKELRFFEEELKRQCATSLYKYENFRFIPAFDATLTGTLKVLALQHSKSGILEKVLKCFSRLVSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZC9</accession>
    <name>L7JZC9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0202"/>
    <dbReference type="HOGENOM" id="CLU_560433_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZC9"/>
    <dbReference type="OMA" id="NCTFADY"/>
    <dbReference type="OrthoDB" id="10315119at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="487" mass="58765" checksum="46B1ADA1CD91FEC0" modified="2013-03-06" version="1">MTIKEKKNGQAMYRLLSTYRLPYGHLVHNNSNYWLKTTKMTIYEYPNLKVRRHSQEKSLKMFTREDNNIYYRNIFIMSADAVDEESFLAYKFTKKSDEILLEEYKFYVADYFYNLEIFSSLRNYDNRIAELKMKEHCKMTESLLIRRKENILLVHGKYEDEKKEDDTLDFTGEVEDDSYFYNYKNKVIMYNTPVLKIKTAKKIKLYDTATEPIINIGNFLVYKKMACIKNCTFADYYKNLYLVVNREGIFLIYKSLIIFKKENNVVGGSIKNMFYYQTSKYVMKRTLGDLFFLLGLFYEYVFITKNDNTYLEFFGSKGLKSVPIHKLEQTTISLILSNYHKFVESFLSDLLKMDTSEAESFYTNLFRQLDDANREYLKKFNYVVKQTANFYKIVLYFPQEVNTFVKMAIAQRKEYYITELINYYKKQKYHLKLRTLRLSLLDNNCFYLYNECLDEANQSLEQIKELMKTERDNIETQFKKDFYYVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZE4</accession>
    <name>L7JZE4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0384"/>
    <dbReference type="HOGENOM" id="CLU_1564076_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZE4"/>
    <dbReference type="OMA" id="ESTDHAV"/>
    <dbReference type="OrthoDB" id="10316549at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="172" mass="19741" checksum="23A6D364EA66CDD7" modified="2013-03-06" version="1">MEPGKKINDVISLNEMLGRKKKMFEIGFVMDDNLANRNSLFRAARYGENESDSSKEKKNALGCARERRYREYDRIGCGSDREMNKYYGDKGGNSWYRNDGYGKIDGAARRWDGHQPVKNEHSSGVRTRSFDYDDESTDHAVQSQSSRRDTQGYESEDEDVVMANILLSLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZF6</accession>
    <name>L7JZF6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine/serine hydroxymethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZF6"/>
    <dbReference type="STRING" id="72359.L7JZF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0167"/>
    <dbReference type="HOGENOM" id="CLU_022477_3_0_1"/>
    <dbReference type="InParanoid" id="L7JZF6"/>
    <dbReference type="OMA" id="PASHRIM"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="261" mass="29329" checksum="EA79DED16BC8804F" modified="2013-03-06" version="1" fragment="single">VGAILLGDISHPSGLISHGLMNNPFKYCDVVTTVMQKTMGGPRAGIIYCKKKYEQLIRDAQTVLCGNSHTHIILQVAVALKEALSEGHYELSLRIQSNARYLRKRLIDHQFDTYTTDSHMILLDMGCAIKACNFEIVADFLGISLDRVSLAIHPCACKPTGIRLGTTGVTRRGMGKRELKKIGKILKCIKNYVEHDFDTKMLNNGETPSVASRLALDQRCLRTEDLKKCPELRKVKQKVRKMTRKFPVPFVLPKNRNGRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZF8</accession>
    <name>L7JZF8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0582"/>
    <dbReference type="HOGENOM" id="CLU_2856130_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZF8"/>
    <dbReference type="OrthoDB" id="10505359at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7135" checksum="F9F536B72CA4BE28" modified="2013-03-06" version="1" fragment="single">VYDNAELLGTFLVECVVMDVRGDVVRVVDGYALGVFYVGDCMHFRVRGVRQGKGNAELVGDRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZQ4</accession>
    <name>L7JZQ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0823"/>
    <dbReference type="HOGENOM" id="CLU_2322001_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZQ4"/>
    <dbReference type="OMA" id="EFNIYKN"/>
    <dbReference type="OrthoDB" id="10416393at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="99" mass="11743" checksum="9E0C2A554BECAF86" modified="2013-03-06" version="1">MKRTRSKEKTITKKITVKTSDHSEEESDENTQLESMNETRDQIMNKHRDYWTNVIENEITEFNIYKNYCVNDTINRKNVKLSDAVEDDLKIIQELGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZS2</accession>
    <name>L7JZS2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993800">
        <property type="protein sequence ID" value="ELQ76963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0039"/>
    <dbReference type="HOGENOM" id="CLU_2499465_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZS2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="86" mass="10111" checksum="B1AA82CD6E421999" modified="2013-03-06" version="1">MKLSEIDMISGKKVILNKECEYFERKSSDFDVNYSHVDSLKHVALKKVKWLAINKILALEKVTIATYKEIEFENELSVLLIYVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZY3</accession>
    <name>L7JZY3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0316"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZY3"/>
    <dbReference type="OMA" id="IICWKCS"/>
    <dbReference type="OrthoDB" id="10463835at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="975" mass="112153" checksum="590B7A827448E031" modified="2013-03-06" version="1">MHFYLRKYAETLLKHIILFEKGVDGSNEYVILEDLKDTAIPNYLSACIKSESESLPTSTIDKDNSRWNAKNVDDRKQNSTQNKLSYFSGLLGFEQLDYEPYYTVMEREEHITYQVINVPFQKSFFEKIVSISQNNIPYFTIDEICIIITEIIPHNDRPELFVYAICIYLYKNPDLVAKMRSMADNSEPIAHHDYQTNILSSFVFNTRYTKNSFREIIDSHVTFMLINQKDKNDAIYALPGQKCKEKIVFCFSMNNLLLGFLIKHLLMNYRTFEANQNVLNSSVCKELHDSLESVTILDINNEKGFTIFNSTTEEQFLAYKLDLIMKSELLQIKCIKSINLYFGYFCQEYDFTCLENLKNLNRIICWKCSLEFVRSIPKHIQVEMHLAEDNTGRIFRKVPKNVVESSFNRCHIYDGSKIPDTLRSIAIQRCRIGRNDTLVFDRKYDYITVEVSKVTIIKFCECFLFEEIVLGASGNSTFRFTNEYTKDRGSVELINAKIVKMQQMVTIGGDIRDVTFEHVKLPLDTVIAFEEGNQRIKISKSRGAFDLKAYIGSILQFKRDTMIEILPTSNSTTNLSRITLQNIQLEQNIVFADTCVHVELINIRMINNSLIKLNKACKQLVMNECNGAIDINDVNSFDRIVICFCINGNNDIKFIGSQTVDHLHLHNICTDVESITSNLKCFKNVKHLQFTFNYSDQTGALTGHSSKTSWRVVLRNILCRNPYRTLDELLPQADYWKALVSSGAEHSVNYILSKVLSENSKDLITKLELSSVAITQKNYKLFVNLPRLSVLNVQSAGIHLNFFKFVPMSLRILNISDSYILRRNSELEGNNTCEELQSRSNNINVITIDVKALLQLHNIGTLLPSLQIIKIEFDPKEITGTISSGETLNLRQLLIMCDESIHDQNYSAVQNCTFIAFIRMLAQRINLRSLQRCIVVSKTTSMVINPITFEILTIKHVVEPDNTKKLENKEDSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K008</accession>
    <name>L7K008_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K008"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0117"/>
    <dbReference type="HOGENOM" id="CLU_1355568_0_0_1"/>
    <dbReference type="InParanoid" id="L7K008"/>
    <dbReference type="OMA" id="YSICCGA"/>
    <dbReference type="OrthoDB" id="10464108at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="208" mass="23952" checksum="9C53745E3640C2AC" modified="2013-03-06" version="1">MKIEIQEPETPHSEPSFALILARELYYLLLAFVFIPPSISDKDYNVVIDFFIFPPLMVLLTLLVSVAFIDTKNTAPIHFLFGIVLMLSYLFIILLSEFYNVVSWCKNEFTDYLHVLKFTLVYLPLSFLLIGVIPQFSIIIALINALCQAVYMCRAFMRNKRSIDLSIHVAHFLFCTITSLVFVLILGKVVYPGYFTAQHVVNSFKQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K056</accession>
    <name>L7K056_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K056"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0422"/>
    <dbReference type="HOGENOM" id="CLU_3052056_0_0_1"/>
    <dbReference type="InParanoid" id="L7K056"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6012" checksum="4BD66DF8C996DB53" modified="2013-03-06" version="1">MAKKPAVQARTAFKRPKSDTIACHQAVNRVEETLLPAKMSALRTLRPTYKACNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0B5</accession>
    <name>L7K0B5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0B5"/>
    <dbReference type="STRING" id="72359.L7K0B5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0291"/>
    <dbReference type="HOGENOM" id="CLU_2607710_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0B5"/>
    <dbReference type="OMA" id="RIEWIYL"/>
    <dbReference type="OrthoDB" id="2193290at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9411" checksum="17BD0AA7B3EC5826" modified="2013-03-06" version="1">MTLGVIHGYQSQGFGSQMLSFVENMARSERIEWIYLHVQLRNVVASRFYLKWNYRVVKIEKDYYKKLDGQSAIVLCKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0E9</accession>
    <name>L7K0E9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">mRNA splicing protein CDC5 (Myb superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993799">
        <property type="protein sequence ID" value="ELQ76971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0E9"/>
    <dbReference type="STRING" id="72359.L7K0E9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0034"/>
    <dbReference type="HOGENOM" id="CLU_1476146_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0E9"/>
    <dbReference type="OMA" id="ACCARYN"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="183" mass="21012" checksum="FA51784906B7A43C" modified="2013-03-06" version="1">MVKWTSSEDKILLLAAQKYGLSHLHKISTLLSRSPSACCARYNHLTRKKEWTRSSDLQLIKYARKMPNQFNSIASLMGTTAAHVQERLDLLVKSDVDAFRYDELRENIHDGEEYKCADKDLMINVRLGNVKNRKEMRKEFIGASDATKIKLKNKSIIDRIMCKKIKCANIREVIANMPAPKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0G4</accession>
    <name>L7K0G4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0G4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0408"/>
    <dbReference type="HOGENOM" id="CLU_3070358_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0G4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="53" mass="6188" checksum="C38A1919E1E66A68" modified="2013-03-06" version="1">MYAIDNRFYRDEKKVRSAIQAGILVGIYNGLLMVECCNLGNRYSMDAYLERSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0I4</accession>
    <name>L7K0I4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTPase Rab1/YPT1, small G protein superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0I4"/>
    <dbReference type="FunCoup" id="L7K0I4">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0I4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0226"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="InParanoid" id="L7K0I4"/>
    <dbReference type="OMA" id="AHCIIVV"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="198" mass="23008" checksum="EBBDCF6250EC9296" modified="2013-03-06" version="1">MHDYDFLFKTILIGNSGVGKTSIINRYVDETYTENYISTIGVDFKIKTLTRHGKTVKLQIWDTAGQERFRTITSSYYRGAHCIIVVFDVTEEESFSDVASWIAEVEKHKVNDTLIVLLGNKIDDQNVAVKNDDVMKMIETYRLDRSLFRYISAKENTDITTVFESIVDKLIERHKLEDGDEENEFADIKIQERTRRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0J3</accession>
    <name>L7K0J3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0J3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0186"/>
    <dbReference type="HOGENOM" id="CLU_2308022_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0J3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="100" mass="11592" checksum="E665D3B28AAA6AB4" modified="2013-03-06" version="1">MILKEIEELQKILSKHIFERTGAFDVDNLHARLEKSQLREFVTQNACFDNDPNIVVKLDDTFKKLPAFEISQENIEVQKSLAELRRKSKFVPYGPTASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQU9</accession>
    <name>L7JQU9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Mad3/BUB1 like region 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3283"/>
    <dbReference type="HOGENOM" id="CLU_1435447_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQU9"/>
    <dbReference type="OMA" id="QFHYSYY"/>
    <dbReference type="OrthoDB" id="10350816at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031522">
        <property type="entry name" value="Mad3_Bub1_I_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17014">
        <property type="entry name" value="Mad3_BUB1_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="196" mass="23332" checksum="D6F8E17E99528A20" modified="2013-03-06" version="1">MTLPMHSNNPNDPIRKLTEMIDEVNFMKYNEEVQTGPIEKYIDHPFFKNNTRVIQRLNELYKSTENENVLFLMYNRSIAQFHYSYYANFADYFIKVCNYAAADYILRKGIRMECYRKQVLVDMLEKLPLQQIVADENVRKVFKRKSIVLFNKEWVNQERSYVSNLVVHCNGQCFGLMERKAYDYLKKTGAKDFAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQZ9</accession>
    <name>L7JQZ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">20S proteasome, regulatory subunit alpha type PSMA7/PRE6</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQZ9"/>
    <dbReference type="STRING" id="72359.L7JQZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3239"/>
    <dbReference type="HOGENOM" id="CLU_035750_9_1_1"/>
    <dbReference type="InParanoid" id="L7JQZ9"/>
    <dbReference type="OMA" id="HQQPLHM"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="231" mass="26682" checksum="BCF638300A585DAF" modified="2013-03-06" version="1" fragment="single">VRFYKPKCWQPLKTMYDHALAVFSPDGRLIQVENAQKASDQGNLIAFSCIDRRIAVTFDQRLLDRMRIEPPVKLHLVDADQNIWLAFSGLRPDALQIISEARYMARQYRYVYMVDISLRQLASELAMYMQRYTITRGFRPFGVRVILFGVEECARAFVVGPDGNYLEYKACAVGQKADKAVQFLENNLKDDCVWNSVCAVRDAAQNDFSKMVTYLIDENGMRIVEREEINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR17</accession>
    <name>L7JR17_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3196"/>
    <dbReference type="HOGENOM" id="CLU_3385065_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR17"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="33" mass="4059" checksum="52D3C71D61A2A4F7" modified="2013-03-06" version="1">MPEHYAGELSEKCVNFLALHFKDEQHRRYMYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR38</accession>
    <name>L7JR38_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Sec20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3182"/>
    <dbReference type="HOGENOM" id="CLU_1519002_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR38"/>
    <dbReference type="OMA" id="RRVWIGI"/>
    <dbReference type="OrthoDB" id="2191686at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="7">
        <location>
            <begin position="87"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ73904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="188" mass="21666" checksum="53D4CE2739278151" modified="2013-03-06" version="1">MSVLDTAPNRMEEQITNLLSIQPKEMEAHVHHVHSLINQYELQSYASSSPDKDLIAKWLRMLRESIIASTQKEEPIINRRDDAEDKQLFDTLSLMVSQVDTADQNILLLSESSVKLKSLCYNSKALEKELHTARNVIARSRANEMKEIRRVWIGIFIYLGVCVYILLGRIGLFKFIVYLVMKLINFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR79</accession>
    <name>L7JR79_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR79"/>
    <dbReference type="STRING" id="72359.L7JR79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3118"/>
    <dbReference type="HOGENOM" id="CLU_102724_3_2_1"/>
    <dbReference type="InParanoid" id="L7JR79"/>
    <dbReference type="OMA" id="AYATFFK"/>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18461" checksum="7A93A0CD8FAC91DA" modified="2013-03-06" version="1">MLRFFQKSKFDCLLHLHYLTKHMLTFVSKNICSSYTSIFLNLSNKFLPIMKIADINAYNKNFELTFMVIKNLGHIKTRDNDVVYSYLVADDTGSIEYSIFNQSLDLGDIIAINYAYATFFKTRLRVYNSELTVVRRVGEFNFEFKMSPNISERQRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR87</accession>
    <name>L7JR87_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_3150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR87"/>
    <dbReference type="FunCoup" id="L7JR87">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JR87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3150"/>
    <dbReference type="HOGENOM" id="CLU_031246_2_2_1"/>
    <dbReference type="InParanoid" id="L7JR87"/>
    <dbReference type="OMA" id="FESNNWV"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="222"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ73954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="362" mass="41045" checksum="7F93F7E26BA2DB17" modified="2013-03-06" version="1">MPCRADFFLRVIIENNRCPATMAKIWTDGCFDLFHFGHSNVLRQARELGSYLVVGVHSLEEINHNKGLPVMNDDERYFIVESCRWVDEVYFDAPFITSCDLVLSMGVDLVVHGNDSIESADGVDCYGEAKARGIFRTVDRTLHVSTTGLVGRMLLRRRSNGNGKRNDTENEITYESAASTVAQSNSSFRTGVDDENNRQAYLRGLLDKFSIPEHKIHGKVVYVDGTFDLFHAGHASILKKCKENGWYTVVGLFNQSVSYKLKRMNPIMSSVERELCVSACRYVNKIIRNAPLVPDKEFIKQYGIDIIVCGANDTSLENYHLVRDLVELKIVGSDFPELTSTAIVQRIIGNYYGYQERNNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRK9</accession>
    <name>L7JRK9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994097">
        <property type="protein sequence ID" value="ELQ73925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3165"/>
    <dbReference type="HOGENOM" id="CLU_3410806_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRK9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="29" mass="3497" checksum="8A50201C8A0AAD37" modified="2013-03-06" version="1">MVCALQYERDIVVEEIEWKVCVQCVWIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRQ0</accession>
    <name>L7JRQ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994075">
        <property type="protein sequence ID" value="ELQ74109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2972"/>
    <dbReference type="HOGENOM" id="CLU_2575554_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRQ0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="9631" checksum="D9C8AD12F06329B7" modified="2013-03-06" version="1">MNSGKESIEEIVEEIVEEIVEEIKEEIVEEIKEEIVEEIKEEIVEEIKEEIVEEIVEEIVESPRLVLYQDLLEEGKYKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRQ5</accession>
    <name>L7JRQ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994074">
        <property type="protein sequence ID" value="ELQ74114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRQ5"/>
    <dbReference type="STRING" id="72359.L7JRQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2966"/>
    <dbReference type="HOGENOM" id="CLU_2365434_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRQ5"/>
    <dbReference type="OrthoDB" id="2194437at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="96" mass="11226" checksum="80A9AD541420DC34" modified="2013-03-06" version="1" fragment="single">VQIKTEVRTHIEKMPKNSIIERSQSEWNSPAFVIRKKNGDVRLVNNHIDLNNITKKDGHPCANMQDLKLDLRGCKYFSKIDLNNGYYQIEIAKKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRT0</accession>
    <name>L7JRT0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRT0"/>
    <dbReference type="FunCoup" id="L7JRT0">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2932"/>
    <dbReference type="HOGENOM" id="CLU_108559_1_1_1"/>
    <dbReference type="InParanoid" id="L7JRT0"/>
    <dbReference type="OMA" id="YYTRTAS"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="16121" checksum="E1B7A40CB2322D72" modified="2013-03-06" version="1">MQSRIYQVEPSSFITTLSSHLKNNNLLTLPPNIDIVKSCSGKQNAPLNPDWLYVRAASVYRHFLTAQIKNERITITRLASVYGCKKDRGSRPGKKVRAGRTHLRSILRDFGRLGWIVEDERGKTVSEDGVRLSEQLIEKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRT4</accession>
    <name>L7JRT4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2937"/>
    <dbReference type="HOGENOM" id="CLU_1289754_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRT4"/>
    <dbReference type="OMA" id="YEEMAHC"/>
    <dbReference type="OrthoDB" id="10360277at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="214" mass="25327" checksum="7116F5D9592F8948" modified="2013-03-06" version="1">MNDQTLLTTPTGTPNTNTPNTNQIETILTILSTSSTPDKYQVIPFLSYLQPIHIPTLVYSIYTMPCYTTCTDYILKVIDQLDTAMLLHLFHYLDTAEIENRFADKFYFLMLAVYERLRVCPEHERVLFELKNIEIKNYVLRRYLERDFNFVLVVDDMLSAPLGTLRVYEEMAHCFDAVSDELKEWLFVRGSERGIKHENRRTVYRVYERIRNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRY0</accession>
    <name>L7JRY0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCCH-type Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_3280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRY0"/>
    <dbReference type="STRING" id="72359.L7JRY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3280"/>
    <dbReference type="HOGENOM" id="CLU_1476152_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRY0"/>
    <dbReference type="OMA" id="CFIHKEN"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ73801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="183" mass="22174" checksum="F3EB294FB89E04AC" modified="2013-03-06" version="1">MLNFSKNIDYVIEDDIKRSQKNKLPYYERKKIELYKTEICRSYEENGYCRYNEKCQFAHSIDELRKINRHPRYKTEICKTYWEEGTCPYGKRCCFIHKENIIKDQDIEVTAIGMSEEVNPVKDKSEIRNLRPFYYKHDDYFDNGLLYVRIDTTFKDDERIPGAFFVPKYDKKVAKFVLDHLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS17</accession>
    <name>L7JS17_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2882"/>
    <dbReference type="HOGENOM" id="CLU_1373068_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS17"/>
    <dbReference type="OMA" id="GHEWTSR"/>
    <dbReference type="OrthoDB" id="10330169at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="199" mass="22595" checksum="57F76C486007090B" modified="2013-03-06" version="1">MVVRHSTALPDHLHANATLTGELRNYKKSFLLDPISVEDLEPSIFLILLFPLYTCLLLLLTSLLSTIPHVQIVPVPYLLGIYLAIQAYLLVSSLIYRWYLTKTSSIVSYMHVLCYTLSYMPLSMLLRVLLKALGFIFVFAYVLVVQYYSSAIVTLGHEWTSRKNVFVFSLITLVISFMFVYGVEAIYTMGIAESASTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS26</accession>
    <name>L7JS26_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS26"/>
    <dbReference type="STRING" id="72359.L7JS26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2860"/>
    <dbReference type="HOGENOM" id="CLU_023964_1_0_1"/>
    <dbReference type="InParanoid" id="L7JS26"/>
    <dbReference type="OMA" id="RKVIWPI"/>
    <dbReference type="OrthoDB" id="2190844at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187:SF1">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="564" mass="63752" checksum="383C0E71A5AD1FD2" modified="2013-03-06" version="1">MPNQNDLAHEIRTLTENEVEQQAVRRAGRFGIYRVSKVEDSKFWLMGGMFFCIAYIYSVIRELKDSFIIKRQLPASISFLKLIYVPPVSIAASALVQKCLIFSSNKRILSYVVACFGVYFLVYGVVVLPLQDTIESSNFNATDDFSDSKMAYKGLESVSAIVLTLNCWTSTLHFVASEVWGTMVLSLLFMSFSNDVCPFRQFIRFMPLFYVLSNVALMGSSITMLGYQHYNKLVDYSTKQMMLRIAFVIIAIFCLAILAFQIILERKILGRVLYTIEGEEQKRTKKVKLSFTEGIRLMFKSKLVLAICGIVLAYNIGTNMIESCYKSSLKIVSMATKQDTGNHVLLKSSIIQFITGLVVILLLISPFSRFIESRGWKIVGIIPPLIATAGFVGVFTLALFNTGRDGENIPPINMMLKSEVSDDTRRKFLQFEETVCLLAVACFKICKYAAFDIAKETLSMKIDKRYRARFKGIYDGVCGKLGKAGGALLLLVSNQLINTTDIRRSSFFYLMISLVIVSIWFYLINYLAGKYEESVKLRKNVDIDLFKGTKKMFSDDEDEPITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS66</accession>
    <name>L7JS66_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit E</fullName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS66"/>
    <dbReference type="FunCoup" id="L7JS66">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2761"/>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="InParanoid" id="L7JS66"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990328">
        <property type="term" value="C:RPB4-RPB7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="80"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="155" mass="17305" checksum="9DF691CF4A053996" modified="2013-03-06" version="1">MFFISELSHTIHLSPNYFDTNLQYAVRSHLLEEVEGACSSDHGFILAVLSIQNVGEAVLNHMGSVLFKVKYTAITLKPVRNEVIEVKVDEVNTMGLFAHIGPLSIFVSNYQIPSNLQESIKKDTLVRLKIIGTKIDKNEIYAVGTINEEFLGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS76</accession>
    <name>L7JS76_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2771"/>
    <dbReference type="HOGENOM" id="CLU_763306_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS76"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="363" mass="41969" checksum="B1DBF6E9A789A6D6" modified="2013-03-06" version="1">MLVVNISCKTLTINRCNCAIDVRNAENFDRIEMNYSMHKGDNVKFIGSICTSSLLLCNIFRNANCVESLFKISTKIKHLHFTNDYTDEANKLSRMFLPNMKSDSALNNRRKTQLSLLAAYTKQTNYFCSIYEGYNDVINLILKKILKEPVMTTLIKLEYDSIVVNENNSKAFKTLLKLKILKICTATITNEFFEQLPSTLEPLDISGSNFYRCFRSVEYKTQDENSMFFHNTIKVLIVDLNVFLAIRSIKTLFPLLKILKICCKSVPKICYYAYDGKIKLQKLYVECCYDYHQSDTKSLEQWVFNNMVGELVKCIDFDSLECFILVSNAEIVSVDPINHTILFKRPRTAPDKSGEMITFEDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSE6</accession>
    <name>L7JSE6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Histone-fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3116"/>
    <dbReference type="HOGENOM" id="CLU_2401232_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSE6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="93" mass="10722" checksum="E6867D56352BA883" modified="2013-03-06" version="1">MQKDNEISPESIKILLKKLAKKRRISGDTVHLLAELAFYTAAFLATASKSFSEEDKSEFIRNGDIKRVFEVLGIEGVYDETYDEFIKKLEYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSE7</accession>
    <name>L7JSE7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2717"/>
    <dbReference type="HOGENOM" id="CLU_1289753_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSE7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="214" mass="24534" checksum="6E38060A54A7399B" modified="2013-03-06" version="1">MITIIFIILARVNAANYDDSLNNIITGTHMSSYDYYFSERTEYHVTNNDETNRTSRRKYLDVFHDAGPRYDRKTSSPTDEYMTNMNWQSPKRSFDNDNHGDNVVNEGASTSDASKQPKNEEELSKFTVTTQDTPNPDSNYQCHAKKRKKLVVLTKNSIDESGDHEETRSEEQYVLLLQEQQSDAEPSNDTVGIMSSKNQRNDVIIEVILSDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSJ6</accession>
    <name>L7JSJ6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2702</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="2"/>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSJ6"/>
    <dbReference type="FunCoup" id="L7JSJ6">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2702"/>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="InParanoid" id="L7JSJ6"/>
    <dbReference type="OMA" id="MEMQYFV"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="565" mass="65300" checksum="A412A99583D6CC95" modified="2013-03-06" version="1">MQKPQKIENLLKKKFFISQSSHIYGGVAGFFDYGPLGCSLRNNIVNYWRRVFASEPNIYEVDSSVILPEAVLKASGHVDKFCDTLIFDEVNGECFRADHYLKDKVDQETCERLDVMSLDEINETIARFDVKSPSGNKLGNATHFNLMFKTFIGPKSQNLGYLRPETAQGQFLNFKKVYELNNEKFPFGTFSVGKVFRNEISPRGGLLRVREFEQAELEFFVHPDEKVHDKYDEVKDIELTLHFGAEVQNTKKMRLKEAVDNQIIKNRCIGYFIGLTHNFLKALGFVDFRFRQHKRDEMAHYACDCWDAEILTSYGYIECVGIADRSCYDLSMHSKCSGTSLIAQKRLDKPKKEIKLEPLCDMKEWGRRFKDRLPVLLEKVKSLKIDENKLIKQIEFDGQMVGLEYKRSENTIHVEDFIPSVIEPSFGIGRLFYSLVEQVYWERRDDEERSVLSLSPVVAPYQVGLTSLRVGDYKKRLNNVFEQLRLRNIRVFVNERNVSIGRRYASADEIGVPYFVTFDSESASDGMVTIRERDSMDQIRVSIEKVVEIIDSLITGNGDFSKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSP8</accession>
    <name>L7JSP8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Integrase, catalytic core, Ribonuclease H-like, LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSP8"/>
    <dbReference type="STRING" id="72359.L7JSP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3023"/>
    <dbReference type="HOGENOM" id="CLU_2160175_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSP8"/>
    <dbReference type="OrthoDB" id="2195216at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="133" mass="15480" checksum="CC37E6A7DD31A75D" modified="2013-03-06" version="1">MNELVEEWGVPEMIITDNAKEFVAIETKTWMTEARIIHEKTSVESHKSNGRVERVIRTIREAIEKIEVNEMGKAIKEVEDRYNKTYHASMKCTPEKAWKDITGIAAVEKVRKEDIVNSLRRENGKNLLKINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSS0</accession>
    <name>L7JSS0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2708"/>
    <dbReference type="HOGENOM" id="CLU_2783033_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSS0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6893" checksum="CE694E84A8A0066C" modified="2013-03-06" version="1">MVRRIKLRFWPCRTCLLDELCRTSMNRRPVAMVKALADQEKGFIIFAVNNGEVGRICCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSS3</accession>
    <name>L7JSS3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2553"/>
    <dbReference type="HOGENOM" id="CLU_1519001_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSS3"/>
    <dbReference type="OMA" id="CPEIRDM"/>
    <dbReference type="OrthoDB" id="2193698at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978988" evidence="1">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="186" mass="21065" checksum="BD61104285AD9999" modified="2013-03-06" version="1">MFLHLISLLAFKFQLKSVSHDLFVGQKNGNVTLVDPNEADIFELEESKNLNQDFVMVRSKDNKVWDISGNATKLIYWSDRHGKINQLFMLIERPGGHVKIVNDMKQCITYDESLNYFIRAPCNNANKHQLLDFVGVGTENQSEGVVVNEMQLNTLKRAASMCPEIRDMLGMAYIAELGESPGNMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JST3</accession>
    <name>L7JST3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JST3"/>
    <dbReference type="STRING" id="72359.L7JST3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2723"/>
    <dbReference type="HOGENOM" id="CLU_177208_0_0_1"/>
    <dbReference type="InParanoid" id="L7JST3"/>
    <dbReference type="OMA" id="VHSKYAV"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="4">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="103" mass="11757" checksum="64FB8E56B0434875" modified="2013-03-06" version="1">MINHHKKIMRIKSHLLAAGYEVTDGIKYGTDFLIYTHDRNKVHAKYACIVYNKQSFLSVIAVQRVVNGVGKVLIFGDVRDGKVMFWRVERLYKRNDGDGTNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSY4</accession>
    <name>L7JSY4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tetratricopeptide repeat containing protein, Hsp40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSY4"/>
    <dbReference type="STRING" id="72359.L7JSY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2452"/>
    <dbReference type="HOGENOM" id="CLU_573664_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSY4"/>
    <dbReference type="OMA" id="KMETIAL"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="540" mass="63104" checksum="612EDA17E3D256DA" modified="2013-03-06" version="1">MPNNKKLSTFILTTVTAVTAALFYYGYKKYRERKRLALGISIKEEGNAHYRNKEYAKALEKYNLALSYTRTCDEEHLNILNNIALTYILLRNYEEALIYTNRFLALDRKNARVVKRRYEIHVALEMPLESVRDAFIAGFLDDNQYGRLGRTALESVAGRETKSVMEKKNVFPSKINVEEYFDTFPGVNRLFLEKSSSEKNDGQKGGVDHKDVKEIHESREKDDGQKGGVDHKDVKEIYESREKDDGQKGGVYDDSRNNITEVPDLQNKNGRKMQYEDYKKIYASKETNSLTLFVKASIEHLKGNNERALSLIKNDVFYYSVILREYLTVLLGERKISKEFLVLMKKRENDLSTLFYAMLIYLKLNDMNYLTCLDKGLQSYPNQFYVLRIWDLIHNKEYNRAEKVLKSLKMETIALMSLACEFYFLIKKYDDVPALIDKMQRMSASDPRAYLFRAMLKIEKNEDGVKEELTKCFELDKTFMKPYIVLGNYLMKRNDKECVKYFEMARDMSGVKDDVEAAVQALILLQVQDMCVKEYPDLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSZ0</accession>
    <name>L7JSZ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2507"/>
    <dbReference type="HOGENOM" id="CLU_2924361_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSZ0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="7228" checksum="5EEF0499D7097A07" modified="2013-03-06" version="1">MPWKDEDPIAFFIKPTEQSIDLSIRGKPRRHKFCKKHFFYPRQKGDVSAVQGQGNKYESMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSZ1</accession>
    <name>L7JSZ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2659"/>
    <dbReference type="HOGENOM" id="CLU_765454_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSZ1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="362" mass="40213" checksum="910B8E3141E1802B" modified="2013-03-06" version="1">MPPPSTPGVMRAPHSSSTYCTASKLTSIYPNKTPHSNTIPRSMNEEAAQYYPGGSQYPSDPQANQYYPGGSQYSSDPLANQYYPGDSQYPPDPQANQYYSGDSQYPSDQQANQYYPGDSQYPPDPQASQYYPGDSQKSSDNRFLSSTEHYTWNTTMLSQVSCDVNQVTSSTSDQTLSDNPNATHSSFVAPLNTDVYLERAYGPNQVAQQQSTTVIIPEKQVCNVSSSNLPETMDVHSRLDEHMSAECAATNLDTAITSSENALSSAKGFSSDDTPQVIDQAYEQRLIKEFEDLMNQIDLNYESEAISYFGPNYKSYFDQKENTDEAGDEDEDNDDENDDDDDDGDDDDGDDDEEEDDDDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSZ2</accession>
    <name>L7JSZ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LTR Retrotransposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2462"/>
    <dbReference type="HOGENOM" id="CLU_206113_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSZ2"/>
    <dbReference type="OrthoDB" id="2194291at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5353" checksum="3849E15F377BA6E6" modified="2013-03-06" version="1">MERIVEATIGSNNLTVLDLKEGYYQIEIEETDKHKTAFEFGNNVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT01</accession>
    <name>L7JT01_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2619"/>
    <dbReference type="HOGENOM" id="CLU_655845_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT01"/>
    <dbReference type="OrthoDB" id="10546247at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="419" mass="48373" checksum="0812E68EF4A2B361" modified="2013-03-06" version="1">MDFNYIAAKLMYLYCDNCKFGALTRLPPQLVELHINNSEINGNLELPEGLGSIVLECTSIHSNVVLTIKDQCKRIEIYKTVGVISFPSIWRLTGIEFSCYYEKVDLWRISDDLFQLVRIIGALIVKNIELGFNTKILQLINVKMSNDSIVKIHRSCNNIMVKDCTGCFDLSDIVVWGKIKFSTDTNSLKLIRSTTKNTCELLIVNIDYVKPIFTNRDIINLYISSTMNFDTDLCLKIHRIVEYVTSWHLKYYLDIPFLMFNGIISRRDQGIDYEFYQCDDNGKSKVIIKNAYIQGMVQFINRNIKEISLINVRVMTGQVLVINTAYESLFMKNCSGRFNIYGIIVSGENYVDLPDTNNHIWFYRVEKDIYNCELSRIPVNKKFTIAHNLQSARLSYITVARRASFNFAQGCKNLCLFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT08</accession>
    <name>L7JT08_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5096 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2527"/>
    <dbReference type="HOGENOM" id="CLU_1566703_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT08"/>
    <dbReference type="OrthoDB" id="10362842at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031512">
        <property type="entry name" value="DUF5096"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17019">
        <property type="entry name" value="DUF5096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5096" evidence="1">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="171" mass="19490" checksum="D2DCA7A9C0174B48" modified="2013-03-06" version="1" fragment="single">VLFHQFFKNNFFGTKESHSMKISIVIQKDDWHAQVAFNISRLLMAQGYYPELIMLCPVNCKTVRQLFISKKERQKKKDSLEGNYDLSIVACDNANILKQGSFESSNVVFIGVPNGTKSSSKMHAIFYGPYDAEYKNFGGELVFVNPGFGKRTLMRMGLDYYPSCGYIVHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT43</accession>
    <name>L7JT43_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative RNA-binding protein Nob1p involved in 26S proteasome assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT43"/>
    <dbReference type="STRING" id="72359.L7JT43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2513"/>
    <dbReference type="HOGENOM" id="CLU_106416_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT43"/>
    <dbReference type="OMA" id="LDFCKKC"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="5">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="4">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="220" mass="25596" checksum="5BBC6C2FD4539C2D" modified="2013-03-06" version="1">MIAVIDTNIIIQRKLSEYEFSKGFITPSILVEVRGEDLNSYLDLYAHKIEIVQPDEKYLKKVYDLQKEKNLLLSVADIEVVALTLQLNGALRRERLSGWITKENIDEKIECLSLDNGVQHCLRLLKCADKGTTSERDFMFRCVSCFSLYEEKLDFCKKCASNLITRVSVKKENGKIKLFLKKGFKMKKTELKDKYGNILHSEDQNAYKMHIREKSRTMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT64</accession>
    <name>L7JT64_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994037">
        <property type="protein sequence ID" value="ELQ74515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2559"/>
    <dbReference type="HOGENOM" id="CLU_2874104_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT64"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="64" mass="7612" checksum="B187EB2E59496D7D" modified="2013-03-06" version="1" fragment="single">VLDKVEILQNKTCHKTTLKTPYKLFFAVDPFTGKQKTMKETEKQKLRSRIEKNNQTNLMKENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT69</accession>
    <name>L7JT69_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994037">
        <property type="protein sequence ID" value="ELQ74520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2564"/>
    <dbReference type="HOGENOM" id="CLU_978481_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT69"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="285" mass="32616" checksum="CE8FA7EEA8A46404" modified="2013-03-06" version="1" fragment="single">VDMQALILYIDDFYRACRVTSSLCKYALDAVSLCMRPEYGDLGSVLSDSPTSLFVELEKLKAAGRGSTPACALRRPDEFIRWSERLSDLRRLFVGYLTTKSGRFRGVVEMCKIGKEVEEDIEKLEKEYNAYLDSQEGSFMSSLRSWGLVGGRKPLFIRSVPMVDVYMAWTEKFMEKVDSLMARGDSAIIALMQNLKENGGVLPPDLVERRKQFWEWRKRTKKDEKPLKVPIGNLLLDFRSGDSSALELERERTFMSIREAILERLLGCWLNSSLYGADRSLCNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTC8</accession>
    <name>L7JTC8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTC8"/>
    <dbReference type="STRING" id="72359.L7JTC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2498"/>
    <dbReference type="HOGENOM" id="CLU_1714610_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTC8"/>
    <dbReference type="OrthoDB" id="2199975at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="153" mass="18568" checksum="7FFEF2A2400C862B" modified="2013-03-06" version="1">MTKIKPLDLQYALKCIYDVEIVYDENAMVYKTKNDVSGFDGIDTFKKKKFKIERYQTEIRRIDSWVKKCNTMNYFKVYFKYFEKELNCKNFKSILDCQVSQTQLTNFLFVIAKKNFSNLFDYYNLGILKSKIKEFVTRNRYETLNKTELVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTD2</accession>
    <name>L7JTD2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994085">
        <property type="protein sequence ID" value="ELQ74022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3066"/>
    <dbReference type="HOGENOM" id="CLU_2074785_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTD2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="13745" checksum="08EF2F852E2A3927" modified="2013-03-06" version="1">MPSMNELILTNLFCDKNIIVNRLGNVNFLEITFSKDQNVNALNFDGYLLNKLCEENLLLNNLQGAMCEIVLFKDYCDQIKTAMHKIVQNFIDAFYQNKLISQIFGFTFEEVRTNTYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTE8</accession>
    <name>L7JTE8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994082">
        <property type="protein sequence ID" value="ELQ74037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3039"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTE8"/>
    <dbReference type="OMA" id="FANSEIC"/>
    <dbReference type="OrthoDB" id="583456at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="941" mass="109804" checksum="6204108A93CCB915" modified="2013-03-06" version="1">MWSNLHNYIDVCIKYIFLFKNKPGLANEEFLIAENPADLQMPGLWETREYIEEIQSLPYEFQSCATIGREWPRNLFFFDRAHYHGHIAGIKRLIYQKHRDVIEKNSDIQFKVIKVPMTYSLYHKIMKLPLKYQIKFANSEICTILKYYTRFDEPIMIQLVKFICEYLLNNKQLLKEIQVYKDYPNGDQCMSLIMKLLIPIFGTKETTTQFKKIVRSHIMFVLIEENGFMIELSGQSLSNSNYILNMNHDGFALAFLFDKVEIEYGWLVDNEDALDTIFNNNRISSPYTVIINDGRKIFDNFKEMGTLKRILNIISTSKFLTGESVNRLILKFENFHANIDMSCLTNMNASVTASCAHCSLEFIKSLSECAKIEADIDKYLIIKYLDGNPRNLTRISCDRIECDNDVKIPDSVEIVDVKTCILASNKTLTLGKNCKSVEIVNMRGKLIISGFMECDMGPGMMCGTLYFDFNTNETIEKRSLRLYRAKIYTKVKIRKDIEKIDFNDVTVTSESIVVLNDKCQSLKITNSEGRFDLRPYIGIAQFFDRNMIIEISTIKRPLYDFFGIIFNGWCFTHTIKLPNIYESVKLMHVSMTKNTEIILNRACKKLIVHNCEIAINFQEMEYLENLDIRLSIDRENNIRLINLRRVNHIRFSDVCWNINLITTIITSIKNIRHVEFNDGAILMSTLFSDLYYNRLMAFITSKGFFENNSDSLSKILAIKDSEPSVFVFEMLNIMTNCILRNVLDKEVMNTVSTLELESIAIDSDNSRSLRKLKGLKILQIRSKNITNEFLYNLPPNLELLDITDLFVKKINRTEKYVIKPSVIIRPYKRLKVLVVDVEFLYNVCSLSVLMPSLEVIEVQYSPTIKINLLVQIKKIKVSELFIQCGNFKREHRHVFVLKECEMLWFLGKLKFYIEFESLKCITFVLFNNRILFDPKTLKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTQ2</accession>
    <name>L7JTQ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-tubulin complex, DGRIP91/SPC98 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTQ2"/>
    <dbReference type="STRING" id="72359.L7JTQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2393"/>
    <dbReference type="HOGENOM" id="CLU_783436_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTQ2"/>
    <dbReference type="OrthoDB" id="2196203at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="2">
        <location>
            <begin position="192"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="354" mass="41625" checksum="7301B532F048620F" modified="2013-03-06" version="1" fragment="single">MLEEVHFQKSFNLGYNLTKNEDPMEEKLNLLVEEFFKIHNTKAEESFLKYLRLYLEPSQDITLSTNDVLSITKKYNLDVNLSIFSPMEVKLIYIFCKLASIRRKRPKIVQKSKINLKRIALGLETVENYKLNMEQDEILGILQNNAFIYTKFKNVTDGQTMSQLHFYKIAKDKVKEFEMQVLILDEEDILLFYVQLKPYIKTFILLDQINSHFQDTKNPYNFLKFYSRDFFTKEDTLIYNIVSSCTKQLNINLNEWLVKGQFTDYAREFFITKNTNDFWLSYNVDTGMLPFFISAEIAQKILYIGKVSNLLVRISSVYEADYSKQATNNLEIVNDGRNILETRPHCTKGGKCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTQ5</accession>
    <name>L7JTQ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exosomal 3'-5' exoribonuclease complex, subunit Rrp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTQ5"/>
    <dbReference type="FunCoup" id="L7JTQ5">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2219"/>
    <dbReference type="HOGENOM" id="CLU_034114_1_0_1"/>
    <dbReference type="InParanoid" id="L7JTQ5"/>
    <dbReference type="OMA" id="RGHGMYM"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="4">
        <location>
            <begin position="51"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="217" mass="24503" checksum="2616D4C1EE89FCEB" modified="2013-03-06" version="1">MFIPGEKVCDIEDNIYSHNTYPHNTSIHSSVLGTLTRINKLVMVEPCTTYRYIPLAGDIIVGRVSMLSVKRWKIEANAQLECILSLTTIALPDNVQRRKLEQDEMLMHSFFDVGDVLVAEIQKVNLGSAVLSTRNEKYGKLTNGVLRVVPLRIVGSYKSSFVENEHLKFVIGANGYIFIQLRHNEAVNYAKMVAALHYFDKCTAHGYLIDDKVLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTS8</accession>
    <name>L7JTS8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquitin fusion degradation protein-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTS8"/>
    <dbReference type="FunCoup" id="L7JTS8">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2640"/>
    <dbReference type="HOGENOM" id="CLU_018981_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTS8"/>
    <dbReference type="OMA" id="CETKFIL"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="10">
        <location>
            <begin position="788"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="862" mass="101555" checksum="645BDA20B5E726D6" modified="2013-03-06" version="1" fragment="single">VFIGYFDIYLAQLFYPHMIRREVFKFFDIKEKITDKTIPENEVEDLFISEMDSWTEEKGIFAFHLIDNYRTSYSLDFKEKILSYISMVLLNPDIVPQSIFAVESGPLVLMRKIVDECDLSYHRIYDCLKDLAEYCDEECAMRILIPLIYQCGKEASRLNLLENFAKYLNAVMMLITIEKVQVWFCDGFIWGLCDSSLFQENDFYRGFMYETNCPCFLDGFMEVFIYEKADLFTRADLVMNKDISELRNIGTMIIHKLEYLAQNVFDILLKLVRKCEKIKNNFLNYLILIVNNNKNRAKMVYDYTEVISDGFAINFNNVLALFCGQIVRKQLFNLINIKVMKIFDLKSIKESENREDQNKTMDEQNGTGYQTGDVSESGKSGSKTQNLSFSTVVLFAKLIFANYSYIKFLEHIKLLDNEIYSMELMQSERDSHSQLEYLRKELESKCFALRIIFSCEFFKQQEEPITSFLIEFTEHVDFCDLPHLYFEVVFQIQTLLIREHQEFLSNRLLGLIEKIMCSKIRNLHFKESVIKILELKTSSLTERLFHALILFYSDLHHFDEFFYEKFSIRYHIHNVLMNDLNEHIKSIAPSTENLRFVNFVIDDTESQLSSALNSIIEIKRCEERLKHTNDREERRSLKSNMLRAKKKATSSFVFVDSSLKMVSFLVEECSILTRNEVLKKFVTILNCNLKMIVGPKCNDLHIKNPDEYNFRPKELLRKIIMVYLKMSNDVYLNAIVQDHSYFNLSLFKRACFICETKFILGQNDLSLFKRLVSKLEAVQNEIVEDDEIVPDEFIDPITCDPIRDPVILLTSNVTVDRSTFDAIMLGDQVDPFNREVLDESKVRDNEEMKKKLDVYWESRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTT5</accession>
    <name>L7JTT5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74705.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTT5"/>
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    <dbReference type="HOGENOM" id="CLU_1220437_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTT5"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="227" mass="27025" checksum="59D27535DCB871BD" modified="2013-03-06" version="1">MYFIIKLYLLYETASFLSAVKLLLLDELLVTTSYGYHELVLLYLNDKYTCIRMDQRYFKNRTLFFGVILANMCDMKKEVKKFILSCEPVFENFRKQENDCLSAVINTIDDFTTIMMRKLRYEVKESRENDALRYMKDIFDSTQDTLEYIVKNKSRFEETSLNKLTECMNKVIDDKQMMKDIILSKVHAENLVEEIIKRVEQFKQHIIKLSDQLFSCLEEKGSFEDSS</sequence>
</entry>
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    <accession>L7JTU1</accession>
    <name>L7JTU1_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Cell cycle control protein (Crooked neck)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ74903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2149"/>
    <dbReference type="HOGENOM" id="CLU_2689556_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTU1"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="74" mass="9367" checksum="584F539F7EF1D736" modified="2013-03-06" version="1">MERVLDEKQRIRRIYEKYLEDRCMDARVWLQFIEFEESLDEVERAEYLFRNALMILKNGVEIIEEEYKKRKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUC7</accession>
    <name>L7JUC7_TRAHO</name>
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        <submittedName>
            <fullName evidence="12">DNA replication helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2067</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUC7"/>
    <dbReference type="STRING" id="72359.L7JUC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2067"/>
    <dbReference type="HOGENOM" id="CLU_641873_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUC7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="11">
        <location>
            <begin position="129"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="428" mass="49148" checksum="1D44C7193E76256A" modified="2013-03-06" version="1" fragment="single">VCQLSKYSTRTKHMLYNTLRYCTTHTNGTECFHLSYYALCSSIGLSYVQISKFCHLFLHPIMVYISYDNPSIKRSKIKSSGCKKTGEPSSNDLSSDISSELDISTFYSDLHHVHQFILTEKKDHVLQGDDTVVYLYGEWDHEMYAPGMCIRIIECRCCSTNATNIYENCLAQNKIAVCASLSKTKDDSAKKVFTITNTNKYLLLVETPTLSVTNLISGMECALQPLFNERIESLNFLYDDRRVILGKLFHVMLQRDITIDALLNEHSLELYTSNLTENEAKKRILDDLPKIINFRKKICGKNEEYIYSALLQMKGIIDIVDNGIIEIKTGNFNTKDVAQVLLYYLVSGIEPLFIYYLKNESFVNVKIKHFDIVSVLNRRNAVAFVYFMWNSMQYDKRAEMNREILVNKQKTLGSSPINQNTHAPTMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUH1</accession>
    <name>L7JUH1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993987">
        <property type="protein sequence ID" value="ELQ75128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1929"/>
    <dbReference type="HOGENOM" id="CLU_323940_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUH1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978766" evidence="2">
        <location>
            <begin position="25"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="892" mass="100324" checksum="138136AC36D350D0" modified="2013-03-06" version="1">MAIAYNKMFIFVFVFITTIGCANGSYERRSTVDSRSSLSRNSHRSRNNEDTAPFLSQPANTTTSQRDLFRHTHRGNECYHQGTRDNSRSSSQDSLGEQPRSGLWHSSKSGDDYTHSSAHISEHTPFPYKSFSGLTSFTHTSGHQRPADDLPSQNMNTRRTNYSHHDPSVLFMGNNRTVTGVKSSDDPANVEYITPTNSGAEHHSDGRSQMNRKQQVMPENPHGIDLKRRSVPNKDGAQSGTDDSDQSEEKTSEPFYLHQNQPMGSSSYGHMANSVPGADFTKITDFTIFVLKQSPDYFLDEEFVNSRAPKREGATITEITDVSESVTLVPTERTETTITESTDVSESETLVPTERTETTGSEITDEIEPETLVPTERTETTGSEITDEIEPVVSEIYANTSMLRSLYDWLYNLCADSVYNMGRAITTIIEKVNELRTNKALMNADESDDLSSSQADDDEILESGDEVSVNSENIPCTPEDIINDDESENGQQTRHSPNAPLATSSSEDSHPQPSLPGDSLQSSNHNKQINDGNKTKKYHELYLFNRSDLTNLNTETYMIPIIMFLEFIISSNRILEFSMCPQRNRQLESLQALLSYNFSDRTPLIRKCSTNGLLQHLSEAVKLFRTQVQINQTIFITIFVLYKKMLITLETEMAQFDDHPLFLSIVSKTKKTTFYGASSINDVARCDSYQISNRFIDSLPSESLPISDRTFASTSQFDITGASQKSHQPPPSKSIMLSEIIMDENNFELTVYPTGNKLFTGSKHQNNASKHIIDSNIKPSTTAFIVDIKDLLSHVYDGTKSDSHVPSIITIRGAILRIDQEMCLNDKRFRLNSFLCYDFSNRCTGFVLYANKFGRVWQSRSQKGIRDVDNINDILAETAKILLICYELVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUP6</accession>
    <name>L7JUP6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2587"/>
    <dbReference type="HOGENOM" id="CLU_2293657_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUP6"/>
    <dbReference type="OMA" id="YEICEED"/>
    <dbReference type="OrthoDB" id="10329196at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="101" mass="11731" checksum="881E418589ABE5BA" modified="2013-03-06" version="1">MESKREKLSFAFDNSQLIKIIKTFTDEEDVKELGDSVVSKIMDRNEIVDVVNYLFERLDELDIEVEYEECGNLVSIMYEICEEDESGGSTIYENIKSCVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUR7</accession>
    <name>L7JUR7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUR7"/>
    <dbReference type="FunCoup" id="L7JUR7">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1994"/>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="L7JUR7"/>
    <dbReference type="OMA" id="EGYNWGQ"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="106"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="301" mass="34538" checksum="AD2053720805BD70" modified="2013-03-06" version="1">MIDEFIEKLFRCQCLTEEEVKQLCEKGKDVLSREPNVVSLKSPITICGDIHGQFYDLMELFKVGGMPPDTNYLFMGDFVDRGFHSVETFSLMLCLRLKYPNRITILRGNHESRQITQVYGFYDECVRKYGSSMVWKEFTDLFDYLPLAAIVNNSFFCCHGGLSPTVDTIDQIHKINRVVEVPHEGSMCDLLWSDPDERIGFGSSPRGAGFTFGKDVTARFNKTNGLSMVCRAHQLAMNGYNYNHNKECVTIFSAPNYCYRCGNMATLMEMDDKGNYTFKQFMPAPETEDKENVKKIPDYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUV7</accession>
    <name>L7JUV7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994018">
        <property type="protein sequence ID" value="ELQ74826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2246"/>
    <dbReference type="HOGENOM" id="CLU_494476_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUV7"/>
    <dbReference type="OMA" id="ANQGMQL"/>
    <dbReference type="OrthoDB" id="10648110at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979166" evidence="2">
        <location>
            <begin position="20"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="551" mass="63677" checksum="B2BB54192F9BBDAA" modified="2013-03-06" version="1">MLVIVFLFVSICCSTYTPAKEDTEISSDEDPTKEDTQVISIAPDDEDSQNKIAMPFGENMAQAGVFGFSTVLLDDYWQTRETMIKLQAPEQKYDKYVNYCSTPGHNHAVIENKLLVKDQKDADHNLAEMYATHSSYTCSSDLSKSTNPTSYEAANQGMQLHSSYTCSSDLSKSSNPTSYEAANQGMQLFNPSTYLPFINPNPVPQMNTYESVHYSLAFIERIEQKQFYNTTRQNPTLISSIQPNFESEIFSLYEDDVCYAGFRALANRYKKLLNRYSNYQFKRFLMMDRFVLMPLLTIDEIQYLNNHHMGDYVKRLQISCFIFFCDSQKYFESVIEKYKELHVILQGIEEIIRQASLVNIKIKNKEIISILRTLKNEQPALFDDFRAYSYKINNLFGSILTKMHAILIFYGKNCSDNTNAINWVHKARAYIYERLLYEIIIPRSDNATLFIGLLTSTVENSTANQEHLESVSDIAVLTDECSSMRELPRVNNPDNFCPQTYEVILSYMSEYKKFVSVIWALNQNYVSLIPILDHNLQLFEEVEQVINKYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUX0</accession>
    <name>L7JUX0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.84</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="9"/>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUX0"/>
    <dbReference type="STRING" id="72359.L7JUX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1944"/>
    <dbReference type="HOGENOM" id="CLU_055667_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUX0"/>
    <dbReference type="OMA" id="HEIGHSE"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="246"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="413" mass="47771" checksum="8D997EE785482F82" modified="2013-03-06" version="1">MKNHYSYAIYFVFTVTVIIIFIELLNALYFRFVLSEDMVGFRKGQMVYELAERNKTSFLSSQIKGSESRIMSVLVDIAKTVFLILVSLLFLNRKFQKFGMRIASGNISIVKRDFRNLTRKEINFICLIAGLFILNKLILQIVSKDKISKYFAIKISLMGIIGYLLVLPLAIFLAYVLLEYFGKKIIVACYLAYIIKILPDVLINDTVNPDKMEQVDVKSFPDDIQHLLYKYHLEDSVYKEKSPGSEKNAALIGYGKGARMEIYGNFTETDQDQLFSVFLHEIGHAKENTLMRKTIIYIALLIIELLFMLYIYDTISTKFTTEIISVFTAFVLLVFIYRALLRQWLLMIYKIASQQSEINSDMFAKQHDYGRELAETLFNIVIDANDFLKPTAVYNFLRSGHPAIYARIDYLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUX4</accession>
    <name>L7JUX4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_2480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUX4"/>
    <dbReference type="STRING" id="72359.L7JUX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2480"/>
    <dbReference type="HOGENOM" id="CLU_021710_0_2_1"/>
    <dbReference type="InParanoid" id="L7JUX4"/>
    <dbReference type="OMA" id="NEDYLVC"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="12">
        <location>
            <begin position="43"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="13">
        <location>
            <begin position="354"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ74567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="490" mass="57692" checksum="15D28B80D6B6A494" modified="2013-03-06" version="1">MPYELERVGTLISQNDAERLIKRIYSFVQVKSNSLCFPGWHAVTLLRRHIVDLVNRDYFACEKSDGMRALLYVICERGRSYFFFIDRKMCCYRILENEPVLLDGDYLLDGEVIITNEDKIEYSVFDTIIFQSNSVMQLNLLERLRLADKFIRHQLCHLFSFKVLIKKMYKAYGFAEAYESRFSLGHGNDGLIFTCVEEPYVFGTCNNLYKWKPPSLNTIDFQMRSENEDVYSLWCMGRGSDMVMIGYFFDFDLDNGYEGDDGCTKGAVSYEKEDSLHPTDGRKLNTAKENVKEENENVKEENENAKERNGKQENENVKEENVPLEEENENVKEENDVKEETNDVKEENVPLEEENEDVKEDNKNELLVEENENGNRNEGHKRLKVNNTCLINNHSESNNQIGKYHKKIGEFHFNENKKSICMDDYSIVKGKWELLRIREDKNTPNSFRVVTNIFLSMRENITYEDIVDHFEEIRRNWKRRESARAQSVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUY6</accession>
    <name>L7JUY6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1837"/>
    <dbReference type="HOGENOM" id="CLU_1147874_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUY6"/>
    <dbReference type="OMA" id="TYLETNC"/>
    <dbReference type="OrthoDB" id="10445969at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="242" mass="27841" checksum="1320325E7EC7322A" modified="2013-03-06" version="1">MLQPSIITHINDKKVQSIGYIAKLKEFYVKLCMYILWLITLAYCSRKLHRYLIRPYENRGEIMKMYGNLKPRIVKSGPNASQMATNQFIAEIEEVAANFVKIKMNSLFLCTSDESNNVEGSPTYLETNCLWKVERLSKNNSNVMLKIGGNFLVKATEKDNRESSYGHKLKLVPFTTADSGKWFWEKYKPNVSKITEYGEDEYSSSSDSDDSSSELVDQKKKKSVIIGVEKKLRPEEKKMFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVA4</accession>
    <name>L7JVA4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1611"/>
    <dbReference type="HOGENOM" id="CLU_482832_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVA4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="565" mass="63294" checksum="89E067D988525A80" modified="2013-03-06" version="1" fragment="single">VKRKIKSEEQGNKVEGGESKEMGGFNNEAATTDGRIIKKESMEMMGVSTRDTEEKIWEVQAGENIWRTRNKNFAAVNNSEKKETCDDGKEAERNGRTNGGPRVVGVSFKVEKPNYGGDVHVEENLVVSGNSVLGEKTNTGVGCVNTKKRFNELRAIYGHNDSERSGGRSDVKHTNDKPENYYLNVRPGYIRTVLRRGKEIMNKSSGEHSPGDQELRNNGHIERRESGTNQTTEPAGSHLLPDASKSHSEVNSITSNLLKANDLLKDETKKDKLSQSSQLIHETNAKEEIFRNKEMIFLGNKDSKKEKKVVTNGKVKDHGGQSVNVHPDKIAAAKSGDSQDEVKKSVEIETEVVGSVAVSRKDHPKKDEGKTKNMYQMVVEQIKDTLTFNQAKPLHKSTRESSEKREKTPNDIANKKSVGRMDVKREAVSEKDVNGDENADIIQNEPVEVSIERKENIVLSHENSSKAETPVEGKHHKSKISKTASTQTDHNMFMKEDYGNHKPGKMPSNVQASKPSAKGRLSQIGEGEYVILTLDELREYKVRIKELIEYFEKLIAESNSRNRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVB7</accession>
    <name>L7JVB7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ74996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2038"/>
    <dbReference type="HOGENOM" id="CLU_155630_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVB7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="117" mass="13783" checksum="D45A6E564FF13F72" modified="2013-03-06" version="1">MNFCFLMSYDLFSIFRFSSMCFNYYWDNNTIPKCSNNKTIIRKMVTNHSKDIKEYFEKSVEILYMYIENHQSIGGLPDISDISRRLDDLDGSIERMVLGLPIIYEIIHKSLINCNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVC5</accession>
    <name>L7JVC5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1632"/>
    <dbReference type="HOGENOM" id="CLU_184681_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVC5"/>
    <dbReference type="OMA" id="KYVVQAK"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="95" mass="11297" checksum="12EE8608AD93EA7B" modified="2013-03-06" version="1">MARIQKSKSKLSKAALLTLQKQLSALLERQKQLIRRKNELDNEIYKYETEYLESGQGYPLTNSLDFYMGQRHEKKKYVVQAKDRVFSALLPRIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVF8</accession>
    <name>L7JVF8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVF8"/>
    <dbReference type="FunCoup" id="L7JVF8">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1782"/>
    <dbReference type="HOGENOM" id="CLU_029507_0_1_1"/>
    <dbReference type="InParanoid" id="L7JVF8"/>
    <dbReference type="OMA" id="TFPMTEK"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="165" mass="19095" checksum="884F6DED8C2EFC23" modified="2013-03-06" version="1">MRKVSKEFYALSAMKMDGKEYKFEELEGSVVLIINSATKCGMATTTFENLVALAKRYHDKNLKILIFPCSQFRNQELMDSNEIMKNIEKYSKEFIVFEKVDVKGDNIHPVFKFLTKHLKGTITDNIKWNFTKFLIDQNGIPTKRYGPMEPVSVDDPIIEDLLSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVG4</accession>
    <name>L7JVG4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LSO1/LSO2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
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            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="InParanoid" id="L7JVG4"/>
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    </dbReference>
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        <property type="entry name" value="LSO1/2"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="10075" checksum="2D57F5CE1D685209" modified="2013-03-06" version="1">MGKTRNYAKKLEGRRRKEEREAEKKRLEEMEKEKQLAEWWLIGAKDYTKEKEKEAKKVEKQMRKEINEETLRKEIEQYTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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                <person name="Goldberg A.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
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            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
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                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="30"/>
            <end position="51"/>
        </location>
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            <dbReference type="EMBL" id="ELQ75325.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="63" mass="7191" checksum="8DA34908CE714A92" modified="2013-03-06" version="1">MLFYYVAPQVSVPNLMLSDKSASPEHLSKIISALSMFPSSFLYAYAAMFFSERLFETESQKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Heinz E."/>
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                <person name="Nakjang S."/>
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                <person name="Goldberg A.V."/>
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                <person name="Becher D."/>
                <person name="Bernhardt J."/>
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                <person name="Rattei T."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </feature>
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            <begin position="22"/>
            <end position="132"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ELQ74817.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15184" checksum="8C42F8DBFF3E55E2" modified="2013-03-06" version="1">MIMYLNFVFLYFFIVYTNVFASNPHLHQMDTSTYDSDDEEVARILSSVEKKDYSHKPSQSMFYQVEPSKSQSVLVMATSSIPKQTHATLPPTLQSTSHENILYTSQKPDYTTYACVKKPAHHQGAYYIQATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVX7</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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                <person name="Bernhardt J."/>
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                <person name="Schweder T."/>
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                <person name="Hall N."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="PANTHER" id="PTHR34660">
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR34660:SF3">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
            <begin position="980"/>
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        </location>
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        <location>
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        <location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="ELQ75166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1107" mass="122049" checksum="4F3AF6AC92A6D0C8" modified="2013-03-06" version="1">MKKSAHIYTFYGIAVVVLLLVLYVFVHKKAVYNPVVEMKRSAMLDELEEEKKKKEEKQKDEEQWKDGDRKDAEKENTERAGNMDGGISTPYGGMAARDMYTNMYGVPPASTPANEYYYPGTGSLPQNDPYTAVQPQFNNTYTGPIGPPTNDSNGQMSKEAEEMLDSLVQDPMFNLTMFMGMLNRIKDENKDGADEDDSKSYVRSRFVPPTLITLPGRYNLGLRRPGESIFGENVGSQLGVDSFSTGTGGPLGSSYENMPGARVPDTGSENASESLGQSLFGEDKKKKDEKSVVPSMFADMGVLGGDGKDKKEEENVSPSFTGITVLGNDKDKKKEESVSPSFTGITVLGNDKDKKKEESVSPSFTGITALGNDKDKKKDNKDILPPPFTDTSSDSERDDGKRKGSDDAMFLPLDGTPAMDRNGGEKPNDSAVSSIFGVVHTSDDKKDKKKKDENSILPSLTGTSALGKDDKDKDKKKKDEKSVLPSPFSDMSILNKDEDDKKKKDKKKDEKSILPSPFFNTSILDKDKDEKKKKKDEKSILPSPFFNTSILDKDKDEKKKKKDENNTLPFSIFGTKHSQTESNNRNETSPSSQDRMSGTGTKASDRTDSSTKESNVPMASNDKTKDKKQKKDEQPVVDRVVKQAIFVAIGSSGNDKGRGVSGDSGMNGALRNGTTNSSIGDSSNNGKSDRTSTDTMNRSVPPQNGHEGPAEQDLLNFSILDNNRDSSSPSADSNLPKDSLQEKTPNRKQKDEGRTDKKFLDSYDLFSSIDDAKKDKRDSTETVGDKYDVPGEVPVKSDTLLTNGGIIKPENSLSTGNEPEGSSGQPSKSQKTGNLSNKNRISANYTESTPIFRDLPTYTNKNKKSKPRSKQVVPIIKFKELKDEMDGMDRLIDEVKDIREMKERSFDDMLGSIVSGGKGPEDKKENGSDKSEAFDLGEKLAFRKVPSTNTSSDAPAVVVTPEHPTVNQEKNPEVTLTAIPKKRVHRRIKHKSHKKRKNAPPKKSEPVVNEQGFFDFFMPGTNTEGDNKDQGERTSHKHHKGKKKHKVSQEISNDSTPGDEHVLVANGYQKALKGDTLRTGQEKVKRETTSRNIVEINSDDYGKEMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW17</accession>
    <name>L7JW17_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1435"/>
    <dbReference type="HOGENOM" id="CLU_883351_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW17"/>
    <dbReference type="OrthoDB" id="2187331at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="315" mass="35211" checksum="066FE3FEBDDF6DEC" modified="2013-03-06" version="1">MLDFLKPQHHILIQRIYRANGQMDDQKLSFFIHHLQLKPEKLASSIEYITRRGVREIRQHGKIDVTCAILTQIVMHFCNRTVEYETVLFRNMAELLEELVRHGIYVECFLEYVLLCCTYVNVRTYRGDEAVNRVLEVVCDNLFELKTYTMSTDVNSAGQLNGAVHPVMSTDGGGIYSFIGAGSANYYANGDERVDESTSCVNPCSSAADSTACYAAIDSSSAETKAGSTDVFVEGPSVIQNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW25</accession>
    <name>L7JW25_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">THOM_2095</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13 16">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 16">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW25"/>
    <dbReference type="FunCoup" id="L7JW25">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2095"/>
    <dbReference type="HOGENOM" id="CLU_015718_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW25"/>
    <dbReference type="OMA" id="YMASCIL"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="17">
        <location>
            <begin position="46"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="18">
        <location>
            <begin position="244"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ELQ74962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="434" mass="48652" checksum="CBD82D223EF3C85A" modified="2013-03-06" version="1">MREIISIHIGQAGVQIGNACWELYCKEHGIQPDGRPDENFGRNDSCLSFFSESCENTYVPRTVMIDLEPGVIESVQKGPFKKLFHPEQLIHGKEDAANNYARGHYTVGKEILDESLDRIRKLTENCEGLQGFLIFHSFGGGTGSGFGALLMDRLTSVYGKKSKLEFSVYPAPKISTAVVEPYNSILTTHTTLDHSDCSFLVDNEAIYDMCRNLGIEQPRYADLNRIIAQVVSSITASLRFPGDLNVDLTEFQTNLVPYPRIHFPLVAYSPMLSREKASHEQLSVQEITSACFDSKNQMVKCNPQNGKYMACCLLFRGDVNPKDVNQATLIAKTKRSSQFVEWCPTGFKIGMNKREPTVLDGGAMAPVKRAVCMLSNTTAIAEAWARLNSKFDLMFDKRAFVHWYVGEGMEEGEFTEARDDLRVLEQDYAMVAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW34</accession>
    <name>L7JW34_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993950">
        <property type="protein sequence ID" value="ELQ75530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1514"/>
    <dbReference type="HOGENOM" id="CLU_383854_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW34"/>
    <dbReference type="OrthoDB" id="7689696at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="721" mass="83247" checksum="175684592F71157E" modified="2013-03-06" version="1" fragment="single">VQYRMSYADDTLFIITNIVDLNKNATYSKIYTCDERYAFKVHVFKIIARDVLLTVDGDLCRWNMRSKTCVARQAVYNALTRIHRYRLVNNFRMSNGIFMMDGLLYAVGGRRGVKVDDFVVDDELFVISDGMHVYRRRERALYDREDERTGYSKDYDQNDNHTQNEKDNNNLYDNNDQTVLDGYERVLSVKLHTPTKILHVFSYTVLMCTYDSLEAVDLPYLIKKVLDQHSDINEVLRIVRTKNVEYSNFRNVYDVRRTYDNFCRIWDGLRMNVRENVCVKGCFGCRMMVGKDGGADDCAVLSLEMMGEDEKLRDDKLRDEKMYEDSRIVRDDKTINDKTMRDDKTMNDKTKEDTPHKTSISLTNNAPVTPAAFIAHFISLNDPLLSTRIFLKCKLPLHALQVVQTTGRMDLLHLIRKEYTDDEVFRKGLLLFDTVFIERLRVMMNVGVVVDERRLRFFVYDYLGMYEHAFYWIGRDNNSDLVGDSKLGLVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW56</accession>
    <name>L7JW56_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993999">
        <property type="protein sequence ID" value="ELQ74992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2076"/>
    <dbReference type="HOGENOM" id="CLU_515994_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW56"/>
    <dbReference type="OrthoDB" id="10500865at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="528" mass="61566" checksum="FB7A4A64854FD9AB" modified="2013-03-06" version="1">MTYNYAQITTIVTVFVLSFNPKYGEKAIGENEYLVINDKTALWFKAEDLLIYGDWDGNKSVKHIRHDSRGSEFAVKLESDSRSDNVKNNEKDTAIKTDINSQNNVAAVKYHVIMLPISKLLYEKISHLSWTSDTEFSFGEICDLLTMLPRFFEREALIMFNIFKNIVKNRSLFWRLNQFFSENKSKQENVHLSNELNWFENISVSFCENGYLILKDQFRNVIVTANDHEQQYKIPIYVELTTNSLFPILVDYLAINYRLLQNSCTDISIIYRETFGLTLDIDFNGFFSKQEEVETCTGETRKLVLSERLRDFYELFDNPLLSLECVNTIILRISSMPYNLNFDFISTKNIQLYCNDCIFSDEICFPISLTALIINDSTINTRLELPQRLDTLIVENCYINTKSSLIVNENCSEITFRNVHGNISFPPYWNLQAIEFHNSFGRMNLQRCQNNFSEVFHIYNVKITDNIELGRNIKTFYLENVQVAQNITLKIHGSCENIMLKSCVGCFDLTDFAKWLKFKFKKIGAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWF7</accession>
    <name>L7JWF7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1264"/>
    <dbReference type="HOGENOM" id="CLU_3224895_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWF7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5073" checksum="8E6E2E391C2FE5FE" modified="2013-03-06" version="1">MQLFLLVVRMLATQEEDKEEDSDFFKPCDKMCCRSGINESGNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWL0</accession>
    <name>L7JWL0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription initiation factor IIE, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993910">
        <property type="protein sequence ID" value="ELQ75868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWL0"/>
    <dbReference type="FunCoup" id="L7JWL0">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1162"/>
    <dbReference type="HOGENOM" id="CLU_056580_3_0_1"/>
    <dbReference type="InParanoid" id="L7JWL0"/>
    <dbReference type="OMA" id="RTKKDNH"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIE beta" evidence="1">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="220" mass="25929" checksum="CC9F3B0BE0E9721E" modified="2013-03-06" version="1">MASNKYAPFPSYKENNRARHINSYIHTIIQFIKNYDRPLTFDEIEKSTNLKLTDNKRLLKTLTKNPKIVIGNNTLLFKPLYNIRSEKDLEDIMIATNAEYGIELEKLLDSPIDIKPFVSNLKRKEVIFVLKDIDNSEIVFYNKLYLPPANDKIVELYNKIKIPNYQDVLKELSSAGIKVERKAQDERRNIVVKKTKIRKYKRKIRITNTHVKELNFNDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWL6</accession>
    <name>L7JWL6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small Conductance Mechanosensitive Ion Channel (MscS) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993986">
        <property type="protein sequence ID" value="ELQ75137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1922"/>
    <dbReference type="HOGENOM" id="CLU_475676_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWL6"/>
    <dbReference type="OMA" id="SCMINEL"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="7">
        <location>
            <begin position="412"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="593" mass="69411" checksum="767AA61761B71678" modified="2013-03-06" version="1">MEMYLTILTLTLVALHTVSVFAFYISKIKTVSFCGVLIFGLVSPYVFSCMINELEIGIYFRVLSRIFKYYCIISIIVAINVIKPFEHYIMCFVILALVAIIDIYRAYMVEYAKDMYRARLDSGVMKNVLKFEKYVLFELGMLKQSELDTHHETVKTFWKRGQPVSLDPEMSFRRWSGKKRPGQIRREPLKDLNRDELADFLGFDRNEIGENIIDETSESGTEQLFYRTRNDNEFDIVSHQGIRMLKTITKVPTLSHLENFKTVKQLPNDELARIAKKYRFRTIFDEQQHSKKNYDPSLLGTITVQSLRKRFEVQHAIEIYRMISHGIHGDVVYDNFRWNIRQLNIERGHLHSSIDDYKHLKKVLTTFSALIILVIILSLSPLLLKMKIPYLRIPTPMLLFGFLAILKDPLTSFIFIIYSHPFDSGDRIVIRGDTHMVQKINLYNTTLQKWNGELISISNKWLANHITKNYRRSEAQKWEIFVIIASNTPVSKIDELKKKFKSLAKKHRDDYPSITCNVVGIENSNKMKLVVYVTHSANFQIGLYRWKRHTLFMQYLIEYLTELNITYLPMDTPVKVDGVSVNDELFMDMCGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWQ8</accession>
    <name>L7JWQ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993912">
        <property type="protein sequence ID" value="ELQ75864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1178"/>
    <dbReference type="HOGENOM" id="CLU_1897667_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWQ8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="134" mass="14876" checksum="C1ED45A62CA1C085" modified="2013-03-06" version="1">MILPNNTIQVLTSQYNISSADNNTMSGITPNNTHYNAAIHPSNLTATLSTPLDGSPPLFPPRNYILIGFSFAILVCLGLWLLLKWYIESRRPVKAFETFCGVRMSVNTLGQDSLSDDEELHTEIEYDGISINTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWW8</accession>
    <name>L7JWW8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1256"/>
    <dbReference type="HOGENOM" id="CLU_2661429_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWW8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8855" checksum="20E5A229B508EFB4" modified="2013-03-06" version="1" fragment="single">VLVYLLRYICHANTPIGVIYTLSMSSCDGYVLGRVVVFVTIRMGRKCMVVYRMIERMNVVNRKHFFDIPGYYVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWY3</accession>
    <name>L7JWY3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein Mei2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1271"/>
    <dbReference type="HOGENOM" id="CLU_1469214_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWY3"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="2">
        <location>
            <begin position="57"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="184" mass="21360" checksum="DD7E9EED23D66EA1" modified="2013-03-06" version="1">MYNSDNVERTGIQHGTCCAAAGSSLYSSHLVRLKTLPYFKPTPFTIIPSLIHQTTKLTVMLKNIPNKYTSSMLINLLNEDHYGSYDFVYLRMDFLNECNVGYAFINFVHANYLCSFYYKVHGRGWTKYSSNKIAEVTYASIQGIDALYRKFRNSPILHEQESFRPKMFYRDGPFRGIEKNVFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX44</accession>
    <name>L7JX44_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993887">
        <property type="protein sequence ID" value="ELQ76043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0994"/>
    <dbReference type="HOGENOM" id="CLU_1295214_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX44"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="213" mass="25366" checksum="C33313582C121990" modified="2013-03-06" version="1">MNILIKQIFYCRMRNTLESISLFEFQLDAANAKRLKNSFPLTNISIDYRMLDPALLLNMSNDIRTLKIAFDVGILTDRMKNRAIYKYEIKTLLSEQNEIEELTISLHFFREWVSLSFLPPNLKHLKITCFNFDLYSINAGDEKLNVKKLTIHHCRNICQIIKQNDVRQKIYFQKTYDFISQLIEMRNLDELVIENSEGIIYYYTPSKYLRIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX62</accession>
    <name>L7JX62_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JX62">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1140"/>
    <dbReference type="HOGENOM" id="CLU_389422_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX62"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF6">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="10">
        <location>
            <begin position="295"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="9">
        <location>
            <begin position="431"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="709" mass="79058" checksum="DBA4791AB8205E23" modified="2013-03-06" version="1">MXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIKAICPRQILSSRGYPTVEIDIVSDQDEVFRSSAPSGDSTGAKEVAVLTDKGKSYNGRSVTGVLKKFEEEIVPLIFKSRISTQIEFDSVLYIADRTPTLSTYGANTLLPLSLSFCKFQAKTEGLKLYEHISRVTKNEPRMPLPNFNILNGGSHAGNELLFQEIMISFQNDTFEKNLESAAGFYATLKCVIKDKFGGIYTGFGDEGGFMPPVRTLEEGLDLLREVQQRTNEKGLRIAVDAAANSFFSNGKYTVHLKDGEKELSGDEMIDYYRALLKEYTEIYLIEDPFAETDLETWKKFTAEFGDRLIILGDDLLVTNSKMIKEAAEKKLCNAVLIKPNQIGTVSGTLEAVQAAKENNFKVMVSHRSGETEDPFIADLSVGVAADFFKSGAPRGERMVKYNQLLRIEEDLMRRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX95</accession>
    <name>L7JX95_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0964"/>
    <dbReference type="HOGENOM" id="CLU_1251510_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX95"/>
    <dbReference type="OMA" id="ESIYLWK"/>
    <dbReference type="OrthoDB" id="10347220at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="226" mass="27554" checksum="8C939788199052ED" modified="2013-03-06" version="1">MIHKQMLSLRAICTIIFLSDIFVLTILISFFLVHYMVIQHESLKFENEIQATNYTKIRNIFGINDKSNELQILFIKQFNHYDNKTYRSMLIKTQNDDPYNNLDARKGSNTYLNMFTDNDRKNTLVYDQPIPRRIKYFKRLESMYLWKIWLFLDVIRAYKIYNKVYEMLVSDEDVNYSLLYVNTKDKCVHLQHFKNRHENLIKQTVNFELDAHKIVLWILGNYRWYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXB3</accession>
    <name>L7JXB3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993879">
        <property type="protein sequence ID" value="ELQ76074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0956"/>
    <dbReference type="HOGENOM" id="CLU_404999_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXB3"/>
    <dbReference type="OrthoDB" id="10522136at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="679" mass="78384" checksum="0B7C4F6A11568C22" modified="2013-03-06" version="1">MKRTNLGRRCRKSDCQCGAVDKRVRSGTELEDYREHNKSKHAHCEKRDKTKKNKQSDRRRRVIKYIVALHDQGVLFSYDGTLLHCYHKGTYQRIRLSDRLHSVTAEHRFIYVCTKCAIAELCTNNVFYAQNSSMCINTIDEIVVAYRDHLRMYKNGRKIYKHSFDEHVRVHSTVHPRELYVCTDTNVYVLNVRTGECEHVICTPAKIQEVQSRNGTLFFITRNVLYVLYIDRTVKAVEYEMEKPHLQINDRFVILYDWDGQFLFFERQDVTYCGSVRYEMEGFEGFCTDQDVYHFVMREGVYSFVGHGLILNSEDGNAWLKGRKNEEIEEDEDEKKIEEKGMGSTTTRGKIKNNEEENESVTDSNVKNNVGSNASIPVNDSNTRNCFFKDPLMVSADKVIYASNVRVIRRIFKNRRKGGKLKIEDLYVLYKNYKEKRVIQRKIRSSLYDCLEEGRNEKDAEKKDSGDKNGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXATELLLTKKHCNKVLYCACKTIDKLFILNAFIGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXC3</accession>
    <name>L7JXC3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1069"/>
    <dbReference type="HOGENOM" id="CLU_3368782_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXC3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="3953" checksum="EF940B66A9CBA35B" modified="2013-03-06" version="1">MVSAQYVRRGCLGSIRNMFDSSKEKSIDGNFNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXJ2</accession>
    <name>L7JXJ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993887">
        <property type="protein sequence ID" value="ELQ76040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0991"/>
    <dbReference type="HOGENOM" id="CLU_2656204_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXJ2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8789" checksum="26811099A658B73F" modified="2013-03-06" version="1">MICFSQLFDLPKACLNFKNNGMFGLSKNRFVDGQIMELRNYEIENGKTIGYDIKHLVLQKVTATREIDGNKNDNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXN8</accession>
    <name>L7JXN8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA replication licensing factor, MCM2 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXN8"/>
    <dbReference type="STRING" id="72359.L7JXN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0779"/>
    <dbReference type="HOGENOM" id="CLU_973817_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXN8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="286" mass="32955" checksum="872B50C8F6EEEF2F" modified="2013-03-06" version="1" fragment="single">MQSYTLRKLIAKKIPIVLYACNKTSESNNDKTTNNHRATLDTCKIQQYLTTTLKDVTVINAAEFQECASVVQSTIVTKQNGNLCVSVLNGPLHRLKTGSTVFISNIDRNVNLFYFLKDKMRTASFVFSSAERLHFKRVMEIGVVRHERVHWLVNAVNERFGVEGSNYGVLKDFILPGRDEPYLKDEVSVVDGEFYVQVREEQQMDGLPKEYERRVRLYRLLSLVYAEEGYEKRIMINAYLRENCGLTEEDVLSSFVSTSWNDQRGMFYEDGLSFQSNHPNRSDRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXR9</accession>
    <name>L7JXR9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase</fullName>
            <ecNumber evidence="2">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXR9"/>
    <dbReference type="FunCoup" id="L7JXR9">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0815"/>
    <dbReference type="HOGENOM" id="CLU_084564_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXR9"/>
    <dbReference type="OMA" id="RNTETKH"/>
    <dbReference type="OrthoDB" id="2193051at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106435">
        <property type="term" value="F:carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="269" mass="31647" checksum="F0F8A80C2E42431A" modified="2013-03-06" version="1">MITCLFIGVLINYKSVCIHASFKLPIEMDNNKLVTLNIINDKTRMIRITKKAFKHIGIILYFMFYCASVITFAFQNQLIFMAPKDYKLTDRETPFARIETSEKNSELKIYVKNNNSETDLIFFHGRAMSVNVLNKITEGITSYNVIYYYCRGYENGTFVRNKKNIMDDVSTLAEFVYSRPKRKMVVFGQSFGCHFALYFTTLMNRDLILVLENPFYSLRSVIQYQFSLPLYLLLVYDYRNAELLKRVKNKIFYFYRTTTSICLEGISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXS0</accession>
    <name>L7JXS0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXS0"/>
    <dbReference type="STRING" id="72359.L7JXS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0763"/>
    <dbReference type="HOGENOM" id="CLU_074702_1_1_1"/>
    <dbReference type="InParanoid" id="L7JXS0"/>
    <dbReference type="OMA" id="DVVYSIH"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051720">
        <property type="entry name" value="rRNA_MeTrfase/Polyamine_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290:SF0">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="3">
        <location>
            <begin position="72"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="231" mass="26434" checksum="EBAF8B7B6A5E0D2E" modified="2013-03-06" version="1">MDVQLLDHAISYLDYIVKLKFWAKIILILTSLAMKLKDVKSRLSQLKPFKTPKIKYEQYITPPSLSATTIHMIETVYNDIHGKSVLDLCGGTGMLGITCAFYDPLSVVNVDIDRDALEICRTNMLMVDKHVDLINCDFQNLRLNTKFDTCVMNPPFGMKCKGSDVLAIESALRCSNVVYVLHSTKTREYYLNKFDNIEVIAETKYDLPSSYLFHKKKNKVIDVDLYRIANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXU7</accession>
    <name>L7JXU7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1440"/>
    <dbReference type="HOGENOM" id="CLU_1983123_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXU7"/>
    <dbReference type="OMA" id="IHFNEEY"/>
    <dbReference type="OrthoDB" id="10367725at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="126" mass="15237" checksum="AEF2602B8B6B7179" modified="2013-03-06" version="1">MLVNERLFLRNMFLAIILSIITIFIHFNEEYRVEVNQITTKNNKLHKFLELNTNNYRELLSDDWILSVNYKINPYEDMNIYELLYTVNIASLSLDSFENVRIFDLLNLSKVPGFFLRHKWCNIRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXZ7</accession>
    <name>L7JXZ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Ras small GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXZ7"/>
    <dbReference type="STRING" id="72359.L7JXZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0857"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="InParanoid" id="L7JXZ7"/>
    <dbReference type="OMA" id="ENIRTWF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001204">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="213" mass="24594" checksum="8F3F081F906FCDDC" modified="2013-03-06" version="1">MIIFRKKHSPLMPSKKDLTTYKIIILGESYVGKTSIAQRFVNDEFDTSLFSTIGIDLLKKTVTVDGAKVRLNIWDTAGQERFHSITKSYYRCADGIILVFDLLDLKSFDSIDRWFEGIHRETDENVPIFLVGNKYDDAEHRVDFVLDVFEEKARSMNVEFFVTSAKTGLNIELLFTRMAEELSKNENVLGTPIDEDKFVLRAETKKKSWKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY33</accession>
    <name>L7JY33_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0656"/>
    <dbReference type="HOGENOM" id="CLU_1870147_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY33"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="137" mass="14847" checksum="1365E5D161304EF6" modified="2013-03-06" version="1" fragment="single">VNLVNLHLPPGVAVAVSPEVGSGVAVSIKVCVGASGCLAECNEIKPIERRMFILWKGGVMCYRLMTENCSEGVFFCQELNTCENPETRKSLGCTPGRGSHARYNLRVKVTVAVAAYFSILVRARAXXXXXXXXXFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYB4</accession>
    <name>L7JYB4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYB4"/>
    <dbReference type="STRING" id="72359.L7JYB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0572"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="L7JYB4"/>
    <dbReference type="OMA" id="IRNEGCI"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="42"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="369" mass="44379" checksum="90934E10B6B8738A" modified="2013-03-06" version="1">MFTKKDFEHVQILERNFLCTYHIVRYRLYDNPEREQSKRTKFCRSLIRNEGCIKEFYFKKLFARNTHKLSQLYIYFMVRVMKKKKMVSYDKLKLLKQEFDVRRSVRHTFLINFICSFQDLKQVYYVTELALGGYFFYYLRDRKRLSSDEAAFYIAEIIIAVQYLHRKKLLYRSLFPNTIMLSETGHIKLRLDFLNKQGLELNDFENHIQYISIDYISGDSVRSDSDYWGIGVILYELLTGCNPFLGTNFVDTRYNILYKPIEFPDSFDLSAKDLILSLLKRNRKERLGYMPADAKLIRNHPFFRKLDWNAIEKRKVLPPIDIKTEFEFSATSRSLDDMFGFNYHHDQTDGYGETFKFYGGGQFKKYKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYC9</accession>
    <name>L7JYC9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0691"/>
    <dbReference type="HOGENOM" id="CLU_1157143_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYC9"/>
    <dbReference type="OMA" id="VCCAVRD"/>
    <dbReference type="OrthoDB" id="10342210at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="245" mass="28931" checksum="1C9D41DA1F553215" modified="2013-03-06" version="1">MMPFKMVTREKIIKSTYYQFILIIIIIVLTITINKYFKYLLGLVFLNMSILFFQFIGACQRNEADRDVPRKKIERPRRITKKQNEKVQQKEIADDNSINDINLSLKESTQRAGIPDLPVMRRGFEKFIVQYVIPVSKSNVDDSIDSTDVSNYDIVDNLVKHGFISYDRKKPEHRRVMYVMLRRVFGERGIVVHPECMVYCYVNKERMESWGDPVLAYLFMVCCAVRDGNEWFDKKGMHFLDELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYE4</accession>
    <name>L7JYE4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1280"/>
    <dbReference type="HOGENOM" id="CLU_2924356_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYE4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="7585" checksum="C2FBC993BFCBC3A2" modified="2013-03-06" version="1">MLLTINYGKLIYEIEQKQLDAFHEKEKCPVDKRLRRQLRKIKKKLKKRYNKFQKHVQSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYF1</accession>
    <name>L7JYF1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0568"/>
    <dbReference type="HOGENOM" id="CLU_819372_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYF1"/>
    <dbReference type="OMA" id="PALEINC"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="339" mass="37405" checksum="BB62229E6E8004F1" modified="2013-03-06" version="1">MTQKGTLLADDNNSTQITPEQRPNTSEHLYSDTTNTTMEISDKSAEKSFEIKCHSNLINLRCLPQSEPEQNSNTMITFKTKCYPNGLVNNCTSRINLKKNNMKSITGFDMTCKTKTADALGCTGSIGLGKVKPGIKSGTPKKSTLQTTCRWEMEQNMRGITCSTQSSNLDISSGQIAPFVADCQGDILGRSGTSCVLRRNAQAFASIRPTWFKLNCKGTTNDRPEMSCNGGIVLEETDHNTGNTSDTIFTPTSALFSANKYDPVAEGVFNSLITYDTVQPTFEPKLDLTDPKITVGILVAPLFVLFVGLWIVLWLRRSKHKKIDRSKNKPVQKIKQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYN9</accession>
    <name>L7JYN9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0292"/>
    <dbReference type="HOGENOM" id="CLU_3227278_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYN9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5310" checksum="78B3B0E8E34143E3" modified="2013-03-06" version="1" fragment="single">VKYKNEHYQDLLTNKDKHSFLFIYNGKYIGEASYNLCRIKKNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYT0</accession>
    <name>L7JYT0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993904">
        <property type="protein sequence ID" value="ELQ75912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1120"/>
    <dbReference type="HOGENOM" id="CLU_3387203_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYT0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="33" mass="3951" checksum="94C9FB0E9007BE80" modified="2013-03-06" version="1" fragment="single">VPGRVLKRLNRDGYKDKTTNARRRNQHACKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYT3</accession>
    <name>L7JYT3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
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    <dbReference type="AlphaFoldDB" id="L7JZC7"/>
    <dbReference type="STRING" id="72359.L7JZC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0593"/>
    <dbReference type="HOGENOM" id="CLU_067903_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZC7"/>
    <dbReference type="OMA" id="TYLRTTC"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="359" mass="42317" checksum="6F93AC65B14B5085" modified="2013-03-06" version="1">MTELKKQLEFYFSNQNYHKDTYLRTTCEENDGIAIEKILKFKKLQPCNYSEEDVRKALAESKIVKINGDKLTKAEDKSYGEYVTRKHCDYTVVIEGLDKELSLEEIETELCKYFEPKLIRMMRNGKKKFLGVVKVELESVEEVERVVKLEIPVFGKKVVDGEEEQKGVVNGLQDDMRATKDTNEVAGDKEKDEEKKDDEGKNDEKRKKDEEDVNKMNGKNEMVQAEAGATKMKKEEKSVKKVKKNILKIYTEEDYRKIKGPKDNASEKRDEYLTKNKDKLYKFVSCKEWTIKDMKEIVKDVIFVDLEKKVLRFKEPPEQEKMKINDELEIMRMEQKECQEYAKGINFSDKKKRRKRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZE5</accession>
    <name>L7JZE5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0156"/>
    <dbReference type="HOGENOM" id="CLU_1732774_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZE5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="151" mass="17206" checksum="7D2499524E2DB937" modified="2013-03-06" version="1">MHIGSYQPILHTVKTFFQHSSQEMDENRENNTLINDDGINTFVGESFVEVNTRSRADDNLYSTGNVAKMNGLESAKHVISEKTGANRTTSTEKIPYVTDSSGRYDLGIRQEQQNVTPRENRVNKYYTNFIAKYVKRGHQSVGITNRNKNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZG0</accession>
    <name>L7JZG0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993869">
        <property type="protein sequence ID" value="ELQ76142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZG0"/>
    <dbReference type="STRING" id="72359.L7JZG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0876"/>
    <dbReference type="HOGENOM" id="CLU_839878_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZG0"/>
    <dbReference type="OMA" id="GRIMRIG"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="331" mass="38391" checksum="A37737B42EC04D95" modified="2013-03-06" version="1">MHEYISLNTWYDTTNNKNKDDDMNSEIEYGNPQYSDDEALDHALHYDLLCDADGHSNDYTTNARQSCHTASQSVPYKTIIFDLDQTLYTKTSSLQTIIRHRLYQSLMARRAWSYEQSKQVYIEMSVKYGLGYKGMIREYGMDQRWYDELLDFDFGEVLKVDERLNDRIMRVGNINGRRDTMNGDSGSGNNDRNGKSSGNGKNSGNDRNGKSGDNHDDRDNNGNGNIAFFIFTNSPKEYTKRVLEHLKVPNISKIFYTTYFQPHMLCKPQRRAFELVNTYCRGKTYFFDDKMVNVEMGKTMGWNCFLVDDDLYDLLGCLISEIELSGQYLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZQ0</accession>
    <name>L7JZQ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993802">
        <property type="protein sequence ID" value="ELQ76943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0060"/>
    <dbReference type="HOGENOM" id="CLU_2869238_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZQ0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="64" mass="7395" checksum="75911EF36714A8DB" modified="2013-03-06" version="1">MPSMELIADVAWARAIYKWENSHTYIKTIIDTTFIDRKSRGYPVPQDGQIDILCRNSTAPSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7K041</accession>
    <name>L7K041_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K041"/>
    <dbReference type="FunCoup" id="L7K041">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K041"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0390"/>
    <dbReference type="HOGENOM" id="CLU_731766_0_0_1"/>
    <dbReference type="InParanoid" id="L7K041"/>
    <dbReference type="OMA" id="FESAMSC"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12261">
        <property type="entry name" value="RRM1_3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="179"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="349" mass="40387" checksum="2DCD34755B10591D" modified="2013-03-06" version="1">MEDKINKIFNTRTIRIENVPDALSITSIVDLIKDCELESIVIENGVYYLNFFEYFVFYIAYNELTKEGVLNKDIHISYVESGPMPENKLLAHQAGASRSIYFSNIDDDMDKEYFEDICTKHGEIENMKISKEKRHVQVRFYKFESAMSCMESLHKGSGKNRRYGFHRMKSYNKAFHCNRTLYLGNIQAEITASSVLNHCKGGAIFSIKFLREKKCAFLTFINPHAAEAFLYNCSLNPITIKKHRIKVTHGNNSNIPINMMLALYHGSTRSIKVKNIDDVLDMDQLESVYKDNGAVIYNFLSLYAATKAMENLRSTYGEEQVMYVPDRCGIVNSTEMMMYMQYNEFIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0C1</accession>
    <name>L7K0C1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0C1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0082"/>
    <dbReference type="HOGENOM" id="CLU_628795_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0C1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979179" evidence="2">
        <location>
            <begin position="21"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="438" mass="49962" checksum="3788B3F8ED91BAD7" modified="2013-03-06" version="1">MKIIRDLLIVVLFAVNACCGDDAPEEHARKDKRLVYVTNENASKMLCKKFLVKLKDGTKCPVSLCDAEFFASLFEAFSARDLPTMPMQSPLRQSSQEFAALENQICGGLRAKPVLNVEEFVEIFSLSMPFPDPDHIRCFGVAACENYQKNSDLDIWTEKIATGGIAIYLHRYFKYIEEMYMMFRLLGTLKNYADENLSVCIKPRYGRFYDLLTDKSAKLREFYGEIKKKIERMKESGRLGYIHRCNQRIAGHRKALGMYLREHDRLAQLVKFCEKAKEIEREILRNEEEYNAQLDDPTLGIADASGGVKRGSLFINSVQLDGICQLDVNPTATELYTGSAKTEILGMMRRTAKFGSLPADLKERRQRFWAWRKRNVTDDIVIQMESLCNCLKAKNGDELTVSLLLTNSTCGLITDTSGREGPQLEEIVRLLPDLNYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0D4</accession>
    <name>L7K0D4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0D4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0118"/>
    <dbReference type="HOGENOM" id="CLU_1166545_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0D4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="238" mass="26884" checksum="C1CA6D59D4CF20D8" modified="2013-03-06" version="1">MPYIKGLMPRKHSLLILLLGCSLLSLGITGYVIVSNARNRNLISVAQRERGAEFRDFVNDEQGHGKVRYEDINSIEKETICGDCTALGHDGSFICHDVDVKHSKDARHDNDSTPSSQYAIQNHQPMVIHQTIVPYAMTDSTVKVKPAEPNVQKLIDTQKPETVADGTSSTVYYSCYDQSSDYYSCFTDYSTVDKHIETKDDEDALGCGKRLDLSEKSIARIKKWEKMFNCDLKPFYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0E3</accession>
    <name>L7K0E3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0E3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0044"/>
    <dbReference type="HOGENOM" id="CLU_765453_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0E3"/>
    <dbReference type="OMA" id="WLIVNEF"/>
    <dbReference type="OrthoDB" id="2195547at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="362" mass="41152" checksum="E1EB8067565A55CA" modified="2013-03-06" version="1">MFKLEDFASLRLVDVLQPIIPLIVVSATLNMCRIYSKLLTTTQPLKIILPVTLTYFIPPLIANLVYKQFYVNNIVIGSFFIGCLLFPVMSRMPYILEMSASLCYIGKFGLFSSMRDSKEPVSNVTLWLIVNEFVSIFILKVLSNEHLFSISEGTVVKTLGNIILIYLCRIFHVNDVLMILLIIMVDILLYLKQKYLGQGLANVRINDRQGLKHYFKKRVDMDTQIKKEQKTANGDYLRDGKVFDNRENVKNGGSELEAGNDQKGRKNLAKNGFCEGQEKFQSANSEMDSMSESNTVRLSDIQDMDTADITASKKEKTTKTPKTPKKNTKAKQKDITELSDEKKSSVEKQTKKASTKTPRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0H8</accession>
    <name>L7K0H8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993817">
        <property type="protein sequence ID" value="ELQ76757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0H8"/>
    <dbReference type="STRING" id="72359.L7K0H8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0250"/>
    <dbReference type="HOGENOM" id="CLU_059048_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0H8"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="2">
        <location>
            <begin position="106"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="252" mass="30078" checksum="664D72FCC54487F4" modified="2013-03-06" version="1">MTDHNKPVEELSHCDINMIVDHHKLEKNISSVKRIYIDIDVGSATTLVSKYMGTEISKRIAMMLIIPIIVDTKYLKRRTSVFDVEEYKKLKKIVDVKKKKLKAMKKKLKKARRNDEHQNTEMILQKDMKVYECMGYRFGNSTVKYDFERWIDREGSKVTGIQKNKLGMILSMKMEEFRKDLGFDFYFVGCKMKKQRHFISINFPYIRFFVKKYRFQELNYKGFSYFKIPVEMTRKILMPLVIKSLKGIDGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0K1</accession>
    <name>L7K0K1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993809">
        <property type="protein sequence ID" value="ELQ76872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0K1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0131"/>
    <dbReference type="HOGENOM" id="CLU_1566701_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0K1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="171" mass="19977" checksum="9CAA57B45BF7DD42" modified="2013-03-06" version="1" fragment="single">VLKELVNLQTLVIDSLFESDLAKNIPNQLETLEKIGKKIFEYQALDLCSLDFKTVQNLKKYENIKHLILDGSIIGYESIFDCLPINLESLKFTRFSTGKVNFHKKNRKKVVIKQLILLLDDPSYHPPVLINNNPMRRQYYKLFDYLTNFIDFNKLDYLVLEASGKFVSLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0M7</accession>
    <name>L7K0M7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ77002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0M7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0029"/>
    <dbReference type="HOGENOM" id="CLU_912720_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0M7"/>
    <dbReference type="OMA" id="MEDVFID"/>
    <dbReference type="OrthoDB" id="2191299at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ77002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="305" mass="35823" checksum="69B452AE4D02A167" modified="2013-03-06" version="1">MHFFIQIEKGQKLLFHTSNNLTYSNVYALDTSVEMEDVFIDIDNILYGYSHGTLYKIVDTIIPLYHDIRLISFGTTIFLIANDHLVLMKNETNFQIVKRVPDNIKGLSSCADNYVFWEDSKIYLGERIISVNFTVRELRLFNNAVFVLSTENKFYTLKDYVFDEIINLESIAVIDMSINKFIPVVAFLTDDTIYILDIGNRKIIKAIESYSGRNIIFKNKRELFIIGEKVIEYHLGKDTVRVILEGSSQSKFKYFELDNEIKFSEMDTFREEVRTRLIENKIESKRMVFELMDQIEELKRKLAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQR1</accession>
    <name>L7JQR1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">THOM_3295</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="JH994107">
        <property type="protein sequence ID" value="ELQ73793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQR1"/>
    <dbReference type="STRING" id="72359.L7JQR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3295"/>
    <dbReference type="HOGENOM" id="CLU_940729_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQR1"/>
    <dbReference type="OMA" id="WKEKIIF"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ELQ73793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="323" mass="37126" checksum="F3AD825A507580F5" modified="2013-03-06" version="1">MSHSPNIQHHHGQNTTKLKILSLSYLTMYIYTITSSILTLILIKVVSLFNLTGMDVHKNGHKKIPDGAGIAAIVSFLLHLSVLNKLDNRLVVTFYIAVLDDIMEMTWKEKIIFPILLACNDVQMEEMRVMYVLYRIVMTVFSCNCVNILSGINGIEIGQVIIILLSMMTLKNVDTSTVILFLSSSVPLLYLNFYPSKVFIGNAYLFFTGYFIIFIEHKFVILFYGLQILNFIISLPQILGFYYCPRHRMPGYDGTFLKPSYFRTNKMNMTLLNYLLVLTGPINEGVFCNLFFLLQVVYCTVIIFFIKWNNLEELVGRIIKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQX0</accession>
    <name>L7JQX0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LRR containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3243"/>
    <dbReference type="HOGENOM" id="CLU_033135_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQX0"/>
    <dbReference type="OMA" id="YESICFT"/>
    <dbReference type="OrthoDB" id="10667951at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978940" description="LRR containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40926" checksum="7AE3FBC95A7FCFE3" modified="2013-03-06" version="1" fragment="single">VSVGNLMIFFSNLLWIHHLVHLIFGIKASNNETYTSESFVNDLKMLRNELEQRAGFRYIAIINNLLKSRTEVILNETKENINMPIFFSECLKDVQLVYKTHEYDLYISVLRKNSTEPMEGLIIPVRESDIKQAVYFLKRIKDVYLTIYIHSLPSDVCDFLLNIWKFDFIRHLSIRYHCPEIHRTRLKSETVVFVSILHGFRNLKILAMVNIQISVAQLEGMSKNVLLENLKLKDCDFCMKQSYQGPRSLSSIEFHDKYESICFTTCNVFVYNKEQMKWLYSPGFSIGINLSKCKNLRRLDVNSPYGVCIESKLNNLRCLRELHLCVMQRHLLSSPVHRAVKIFVDYCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR78</accession>
    <name>L7JR78_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3140"/>
    <dbReference type="HOGENOM" id="CLU_1020134_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR78"/>
    <dbReference type="OMA" id="AMEYILC"/>
    <dbReference type="OrthoDB" id="10248579at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="273" mass="32603" checksum="2F795D8031299DB8" modified="2013-03-06" version="1">MQNPLLTMSWAEIKKLPTNEILPNLDLIYNVPHRLSKVLKILTFRQVKHTKILKAAIYLQRSENLKYKRAAMEYILCTYDTFDKSCTYSEYNVPIHSKPCDFLRYDFSAVKRSLSEETVDENLLNFSKNLKNVFNNRMVTDNKEFVKDVVRILRLYGRKKRINLRYYKDLEIFDERVLIILMKEKRFKRIVQFMLCINSVLKPKSRLACAFVSANSEWKEWQANGFPEYKIEEQEIENICNIKITKNKPKDITFDVDGEKEPFNDGWKDWIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRB2</accession>
    <name>L7JRB2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994103">
        <property type="protein sequence ID" value="ELQ73815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3273"/>
    <dbReference type="HOGENOM" id="CLU_2741840_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRB2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8151" checksum="ABF758EB93E02F57" modified="2013-03-06" version="1">MYATHSPYIYRVYSSFSSLCEQAKSSFLSKIIASADSNSVYILGILNYLIYLFILAIREAIDEKRTSMNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRJ5</accession>
    <name>L7JRJ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3006"/>
    <dbReference type="HOGENOM" id="CLU_022546_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRJ5"/>
    <dbReference type="OMA" id="APFDRCF"/>
    <dbReference type="OrthoDB" id="10354760at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="786" mass="89821" checksum="8076C2760A66B593" modified="2013-03-06" version="1">MHKLVDLIATNDIKGIEAEMGRILSTSDLEGLSELLLDERTKIYFLILAEQLMKQFKLEGRSIAPLVAQLERFSYPHAQLANKFASVYALAGTLDWPLHFPNFLENVLGLMARSDVLGFNIFEKFLGHVRHGNEISEKRRKELKEALNVCAERFSPFLVRANARSEPEIARMCIAVFEHLSTILEFDPQVVLSTYAEFDLESFVVSVLERKQSDAFYAFLFTYLSDRPPNAKMLFALDRKSTPFLEYAIRGLVSDEQCFLAALLYLRRRVGLLYDDDCLSDGDGRVGDSRGDGRVEAGERFGAAGAGRGDGLGNGRGDGLGNGRGDGLGNGRGGSLRGDDQTIAGQTITAQIITGPIDDRTNRNTTNRKTKKMQRICKILENIAQRYDSADNYTRNEIMLFFIDVSRQQFDASFLNVEKVPRELLVQLLKNNEVISDDPFVHAYNLYKQRDKRCFNYIELLCTDTEGEKLMVKALERIALSEAELRSLIENIRSARVYVKIATMIPMYSILDVHWDVNVAEKFFYYLQYDEHAAMQHAAFFYEYFMRTDDFKFCFSILMRMRKALMRMNTRNDEPIDQKIIERCYGCVHTLPVAELKYFIEFVGSVRCYAWLLEPVHVRVLKEWRESEEWAELSALTRIYMGVLGRHELVAPLVELLQIDEISLLRRLLQMLGRLGVPDALRPRCTYLLLVLYNSSALTDLQGDVLAMLVEVYDEHTLRMVSNDQQALEEMRGNVKKRKGLMKAFLRDVKGQQLAEMGRRHLAVGAQGIIKKERADSPDVNINGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRK0</accession>
    <name>L7JRK0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3011"/>
    <dbReference type="HOGENOM" id="CLU_004199_2_0_1"/>
    <dbReference type="InParanoid" id="L7JRK0"/>
    <dbReference type="OrthoDB" id="192702at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1621" mass="185940" checksum="A33E4A8D548E24B9" modified="2013-03-06" version="1">MEIVRNTIKWVLCFASTTPEGKHDIIVCDSSDGLPLINLLMDVSDFSWNSRNVFDSEWYDTLEDLLHSIGEVESEDNITTDQKSNETAVAHDTSTSETRRYVKVNIPISKSLYMKIIEMMKNDGHNVWLTDSEIDEFAQYISLFVNEKVPILHQIDYQTRYDEKLMDRIEELCLIRYAASNKTKQTDLSVDNPFFVNLLLEIQTVVYYYVLEDKCGNMLFASETGEYEKQSPRFIGFEDFRSLLPLNFLKMESKFLITNREYMKDLCTHFSESGNNRIVVDVDFSDLCNKQRNWKDMYFNIKKEQVVEAITSEFLKSSFIKRLIIRLRNVECDFSMFFLENENVDLYFDCCTIDNEIVLPCKLAKISIVDSEINTLLEMPANLKVFVFRRTVIEKDCTIYINSDCRSITIDRVIGAINIPFLEEYNYFSSRDTIWSFKLEENAGGSIDNLTRSDYTFEEYLCKIQIAGVLILTHIRISSILKLIIGDNVEDLTLKEFSGFIDFLRPDSTVHFQMNLNYGDLIIVNSEKGDDSRELTISNGNWTDVVDLGGIISGLKNSDVSQYNSLQFNGVRLTKIVFDRCRGRIGCNDIVDVIILAKSYCYFSIQDLNKPIEVRVNNTICMVNCYELTMKDISISASLKLSFNIKKICLERVHVNENYTMEVEAGFESLVMFGCSGKFSIPNISYNDECFVNLPSDRFGRIEITKTSTGLYNITITYMKIESEFKIQMDVDCVKLKNVSTINKSVITFSGKCENLELICFYGHLNFLNSKISDRLVIYESNSTNNDDVISILTRKFQTTEAVSKNETLLPLCSRIPHCRRKHPANRSIVPLRANRNSKIFLSLNENVPVDIMNIFNNIVITGPEKIKENKFPVTSFLSTSLDKLVLEDLCIEEEHEIVRNITDLRIISTEGSTLRINAHVKNLFIERSTLSIDISKIDQLKKLTLIESPFIYDQNIYQSLSYLRFDRMSVGKNIYLAGKLKTLIIESTNIRGCSVLKIGATVVNLSIQKSIGNVDVSRAFKCGLIALYGKEIIELRRDKFSLILRGITFKGNVEIDDGFKTVKLSEIDMISGKKVILNKECEYFELESSDVNIDYSKVDDLKCVTFIKVKWPTIKEVLDLKTVTIAIFKEIKFGNEFICPANIRVISLHCVEMLDNSVFRVNENCEEITLFNCVGRFDLSSATCLKKLAVIPSADSNDEMEVNYPSLDGVIDLELAYESSGKYFDDLLTRCNNFKRFTLHNLWYGTEGSEIHVLPTAHDDLYLYIETYEKTSVFGNFRDHVLKNKSYYGQKHVTTMNILMNKVFYYIFNYNMRIRITYLNVEGFKLDERNVKMLKSFSNLETLILSSYSVQDSFFLYLPIYLKSLRLVYTTIPADLRIPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDLNFFTIRKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRL2</accession>
    <name>L7JRL2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ74113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2977"/>
    <dbReference type="HOGENOM" id="CLU_3193997_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRL2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5115" checksum="C658559B090F55F4" modified="2013-03-06" version="1" fragment="single">VKKKNVERKVVGIDINKKIRRAKMGSSTADSMKVHLSESSSSIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRM3</accession>
    <name>L7JRM3_TRAHO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ74123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2951"/>
    <dbReference type="HOGENOM" id="CLU_1961131_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRM3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979072" evidence="2">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="128" mass="15302" checksum="D6F5A93DFD8EE54C" modified="2013-03-06" version="1">MLYFVIIIYICWKSVFTTDNDRNSRLRSLRSYNRMLRNHSNEMRDDKSETSQRQRTVSSRRELRENKKSKTSLQKSQLVPRKSEMDDKEPDISNKPLSKKEFLRSFGLIPKLVTEDKGKCYEETCTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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    <name>L7JRP8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol polyphosphate 5-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.36</ecNumber>
            <ecNumber evidence="3">3.1.3.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
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            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="EC" id="3.1.3.56" evidence="3"/>
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        <property type="protein sequence ID" value="ELQ73970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRP8"/>
    <dbReference type="STRING" id="72359.L7JRP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3110"/>
    <dbReference type="HOGENOM" id="CLU_799734_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRP8"/>
    <dbReference type="OMA" id="SLIEYNC"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="339" mass="39982" checksum="A7F417198F88CA81" modified="2013-03-06" version="1">MNILILTWNVQKNKNYLVDLHYMLKEKKADTIYIALQEAHDFTVPWAIQKFFMKLFFKAYKYREIERFCGLVTIILSKYRITAVNTFVPFPNLYYNKGAVVTNLGINYTNILLVNLHLHHGVINEARRVNQMKMVLRSIEGRFSYIFVCGDFNTRVDVKKIPTCFDLNEFVMLSDWCNRTCREGPLNADADREWACAYNLHMDKFKKADQMNAFKSIFCLDEFDVKFLPSYKYHARTDAYNLKQTPSWCDRILFKTVNEIECLFYGSNMLVNTSDHKPVMALYQIRDGFELKNMNKKKKKAKYACYAGYTVQFTYNNFILIVIGLTAILWHFFGQLLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRU1</accession>
    <name>L7JRU1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diadenosine and diphosphoinositol polyphosphate phosphohydrolase</fullName>
            <ecNumber evidence="4">3.6.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRU1"/>
    <dbReference type="STRING" id="72359.L7JRU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2906"/>
    <dbReference type="HOGENOM" id="CLU_449920_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRU1"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="487"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="607" mass="67541" checksum="F42B2E06074D4086" modified="2013-03-06" version="1">MEGNSNEEQEQMRNNGYEKIGRVENDSCDKTGRAGNDGCDKLEQRRNSCCDKTGRTENDSHSRMEAKNNCSDKTGRTENDSHSRMEAKNNCCDKTTEQTKNNSFDKIGQTENNSCDKTEQRRNNSCDKTDTTENTQNKTDAQPVVPRGHHSSFLGSKAASCHTTNNLLEKQGRLSREQCEMMVRTTSRVNNSFASSFVDSCGAPVKWCVRIQPLSTRASTSVSHRVPCYGSAYRRALAKRRQNGEHLRNENVRKGVVVMKGSIDGGRNELVSGSAKDTGKSGEVNGAEESRTEEVMAGGTSKTMEINNREGNTGLKNGEVNGTEESTSLKNGNERTVSCGDQNAEITPLENETVKTTTSSNNKKKTVTSSKTNKTKTAKPTSSSSLNRTKHPNDIPPQVASKREHSLIKYRSKLAKGTRRYTRYSRMDIKRGEEPGYFDPFYEQDWKTPSSSISDHSNDPVAVKEPGCSVILTYIKDLIVALCLDVKVISHAGVLGVIGEKIVLVYNSKGKMVLPKGTIKHGEGMKQCAAREAWEEAGIQGPISPRRFLVKDGVAWYLMEVKRVYRHYDENWRGRAVITYGSEFKGKIKKKHIEVIKKGLLYASVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRW9</accession>
    <name>L7JRW9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRW9"/>
    <dbReference type="STRING" id="72359.L7JRW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2886"/>
    <dbReference type="HOGENOM" id="CLU_1587749_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRW9"/>
    <dbReference type="OMA" id="IFKMVAM"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="156" mass="17861" checksum="F983B487D6A85255" modified="2013-03-06" version="1" fragment="single">VLRKLQQKTNNKLKQEHILLIIIALSLITIIFLPIASLVSNVLCVVIPFQRTVRLVIANKPPTLDLIVFWMTFGLLCVVDCSLVVTRVVPFYYIFKMVAMNAIVLDERVCRFVVSGYKRMGFLVEEDIGKRAKEAVEVLKEKSKHLKGELDEMKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS98</accession>
    <name>L7JS98_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin conjugating enzyme</fullName>
            <ecNumber evidence="3">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.3.2.19" evidence="3"/>
    <dbReference type="EMBL" id="JH994097">
        <property type="protein sequence ID" value="ELQ73926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS98"/>
    <dbReference type="STRING" id="72359.L7JS98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3166"/>
    <dbReference type="HOGENOM" id="CLU_030988_15_1_1"/>
    <dbReference type="InParanoid" id="L7JS98"/>
    <dbReference type="OMA" id="WQMDIKV"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="16874" checksum="259C6C392E37334E" modified="2013-03-06" version="1">MKLNKMNVRFLKELKGLKQNMPTHFRLVSHTSTALVLDMYGAPGTIYAGETFTLRLEINDNYPIDPPTAVFVRNIPVNEHVYTNGHICISVLHDDWSPAMTLEMVVVAILSMLSDAKRKSKPPDNYFYTVFKRNKSPRDTKWMYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSM7</accession>
    <name>L7JSM7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2668"/>
    <dbReference type="HOGENOM" id="CLU_2962545_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSM7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6721" checksum="E1F426D1293ED381" modified="2013-03-06" version="1">MSSINISDIEENLGLKIIFILALTSTFLGIYITTYDIFVKQKTSDNRVLEIITFSVDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSQ9</accession>
    <name>L7JSQ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994039">
        <property type="protein sequence ID" value="ELQ74464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSQ9"/>
    <dbReference type="FunCoup" id="L7JSQ9">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2611"/>
    <dbReference type="HOGENOM" id="CLU_078274_3_1_1"/>
    <dbReference type="InParanoid" id="L7JSQ9"/>
    <dbReference type="OMA" id="GPYYMEL"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="5">
        <location>
            <begin position="66"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="166" mass="19285" checksum="ADA6CAAD262F0AF2" modified="2013-03-06" version="1">MSPDELKLLAYHQEIEIHPSTNLPTLHLLETDYGPLSPHISAKVPIHTALFLHNTNLCKIPLPFFLSLDYLRAVKQAEKQHVNEYSPIYPYIFEVYDDLLRCVDGRVEEIRMVISEIKDIRMEKSRRGLVSIDGRALNLNNLTVYEYEQLKSMILDGMEMALKMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSS9</accession>
    <name>L7JSS9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2718"/>
    <dbReference type="HOGENOM" id="CLU_004199_1_0_1"/>
    <dbReference type="InParanoid" id="L7JSS9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1138" mass="131074" checksum="CB434FA2D6CACB39" modified="2013-03-06" version="1">MLYCNLYLPDNLEVVTLERTEIMKYYMLNVNDACDKITMTLVTGAVHIPYIRRTLNIQFQRIWSFKLLRYRNVIEELVIDGVKLMSSTTIIPTSIRRITLRNITTNDSSVSVVFPTDIKEITLDEFNGYAQFKGFTNELSMFACFNRGRFRSKRAKENDSMLDIYMEGATLFELRNFLPIVSSIYMSRVDIRQIGVLQLSANINELSISNSIGTVNFEFIPHFKGFEFQEMRMFDKMCHKLHFKKARNGQPSHLYVANFQIQETIHFRPEIDEYVFHNVIVIKPNYVAVDKNFKRVKLTNCKGRFKIPGFVSNDKFGTVDVYNGYCGHLEVTRQHEESFDILVRNLIFYKLVIRTNINTAEFDQVKVVKWLHIATSQCKRLILNKFTGPLFVPNITSFKALKLFYLQGLNTLSELPALGKQIRSTQETPVNVESNQVVTLSCTDIAMPIVIGGDNDVNISISKCTFPVNVIGVLIDAVADKSSFCVVSGTEFYLISSYEQEPSELKLVSHHFRGVWRVKKDIGFLSLIKITSTDDSVLQLNEGLHSIRLDSSKIDIDATHAKNLRTITLINTISIAYNPAIHHSLSYLSISDMNIDFGFDLVPSLSTFLLKNCILVPDVVIKVNEGISLLSISRFDGTIDMTRVTGLKNMKFNQGCTLYCDKCTRTPENSLLYIENYTFEHNVAFFDDIETIHLKNVRTAEKTKLTLGRRCKRLKLESLAVNIDLSQAALLEKVTLKDMSDLDVKDFLTRLSTVKILVLENVDIKNDLKLPYQIRIIILRRTILANNAHFIFNPKCNEVRLHHCIGVYDLSKIENLEVFGLHPELVKKSRFMVNLPSLNKLRELDIAYNLNNECLTYHCPMKYVNLQSLTVRTLDHLDKSTPYLQSSFTLYYILNSIDHNTWSYQKIFKYMPAYQPLSDSKTNFLSIKTNIFMNQFFTINLKNKLEYLNLVGCSLSKENVSVLKEFTSLHTLIIDCAFIDNSLFINVPDQLETLEIIDRKVHENLHVNLHNLDFTTVQSLKKHKSIKNIVLDESIMRYRPIFDCLPLKLESLKIKKFPDVVNFCAQSDQKIVVRRLTVLLDGPDTYPLTMIDSNPMISQYYQLFNLLRNYINFNELEELALEASGKLVSLDEKTYQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JST5</accession>
    <name>L7JST5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JST5"/>
    <dbReference type="STRING" id="72359.L7JST5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3281"/>
    <dbReference type="HOGENOM" id="CLU_542037_0_0_1"/>
    <dbReference type="InParanoid" id="L7JST5"/>
    <dbReference type="OMA" id="IPICPPY"/>
    <dbReference type="OrthoDB" id="2196318at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978695" evidence="1">
        <location>
            <begin position="18"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="503" mass="56726" checksum="D8E80A800B9F607F" modified="2013-03-06" version="1">MLLFSSCILAFLAFILTTEKRVQLVPKKCNEDPMEICKLNGMAGVMASARNLPFLIELLRTNKIDAAVVCGWNGTPGNFVLRANGALAPYDPLTNNASYAFCYGKVYYGYGNKIPAPSTYVSYYQKNKESLGDYGRYQAYEKSWTPFYKENKQFPGAYTEPSIPFYPQYNNESCIPICPPYNKEPCIPICPPYNKEPCIPICPPYNKEPCIPICPPYNKEPCIPICPPYNKEPCIPICPPYNQEPCIPICPPYQPYKPCIPICPPYPYPPYPFPPFTPDNIPNIPCPWEKPFSYKYKAKCKKFPQREKMIGYNPVQPTKGDAVSFTQECISTEKTFIIDEEDLGTDQRVKVTEVTDVESERTRLLLLAAFQSGGPKLDVPFILRFPNTLLALKNYLQTTMKVQNPCLYTNKNGDVFVILNNVLNRVDFSKKPGTVTAARLLSVKRVPYKLPSFAADPPPPPPPKPTPIVPITYEFTPITGQALTSLIQMGLYNITFKSTITQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSV8</accession>
    <name>L7JSV8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine phosphatase 2C containing leucine-rich repeats</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSV8"/>
    <dbReference type="STRING" id="72359.L7JSV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3267"/>
    <dbReference type="HOGENOM" id="CLU_963738_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSV8"/>
    <dbReference type="OMA" id="CLIHQGR"/>
    <dbReference type="OrthoDB" id="10389386at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="289" mass="33350" checksum="D2B668ECF0B158E8" modified="2013-03-06" version="1">MSREENEQVREETVAQGGVLRTSVCTATGRCRRLLRYIKSSDLSVVVCSLLYNMLLVALLGLFYVYAVCRLGFIIYQVYAREKGKERDERDEEVAQNEPFNITSPLGFDFTISPQDAKYFNPGNFILMTDIVKSTYYMRHYGRGMKNALKKHFRQAERLLRQFRGYLVAVEGDSLVCLFTDFQDAVSFGNELEKFSQKNFITGNENLRLRCLIHQGRLDMVMMPYGVSIVGRTIAEAYVLCDNAKSEVITVSDYVYNRHIKYPGSKVRSSLRIEKICVNDICKYMFSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSY0</accession>
    <name>L7JSY0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2496"/>
    <dbReference type="HOGENOM" id="CLU_960381_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSY0"/>
    <dbReference type="OMA" id="CAQSECS"/>
    <dbReference type="OrthoDB" id="10307720at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="290" mass="34898" checksum="9EA04EA4DD82BAA5" modified="2013-03-06" version="1">MDLVSTYSISFNRFAVNMNGNTIVFYNYLGRRFLLVRKNDYRRLYNFTYDELQKIKFISWSEKGENLVICHTDEVTAFNIYTKKTELRLSVDKMVLGAYLLDNRKILLEYQKEIKLINQCAQSECSFYIDSYTKAKNRIVFIFDGYLTVLNLDFIVLFQRFISYCQIKQFDIYKNKYYYNEDGIIKGVDYVFECKDEISEFKLTKNFVYCYSKKNLKIFEKHSDSVLLALEADSFFLDKSREILYLLYDNSFLVYKKPRKCYLFQMIEGNITYKEREYEFDLSDNVELIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSY1</accession>
    <name>L7JSY1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3227"/>
    <dbReference type="HOGENOM" id="CLU_1541194_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSY1"/>
    <dbReference type="OMA" id="MMDMNRD"/>
    <dbReference type="OrthoDB" id="10360644at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="174" mass="20678" checksum="8740383847701EA6" modified="2013-03-06" version="1">MPRFSAQSLETYNTHLKSSLEALKQNYAPSYHQETKDLITACIDLINTTKQRPRHVEEFNMLYNSYKSYVKSRNNINTMIERAASNRNDKMYRINDGIGEVVKLTGLVDELVHGQREFVDNVEIMMDMNRDTMRRSNDEMKVTMRRRKESKMWKQVFGIMLVFCVLYCIFKIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT21</accession>
    <name>L7JT21_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT21"/>
    <dbReference type="STRING" id="72359.L7JT21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2492"/>
    <dbReference type="HOGENOM" id="CLU_091759_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT21"/>
    <dbReference type="OMA" id="IDQFHFF"/>
    <dbReference type="OrthoDB" id="2190184at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="283" mass="32788" checksum="615D1C60D9F5B19A" modified="2013-03-06" version="1">MLSVSVISVKFTGNKELFMLLQRLTNDKGVLTVPIASLVIERDSMNGLFIESLDTTGLFQPRNLQTFYVQAFILFVVNLYDPDYLETFSHPKSELVFLKSSTAKKILAPKKLLKYWQNVFHMMYSNVMVHSNYHRTSILFDNIDQFHFFDDDPKSKTEKVPIDDFLMILLQRKDFVEGGIVVAVKDNCLTARNAENYFVPNEKKIKKLSKCFKIGYTIENDVYDFLSKIRTGDYSSHIIASESIEKSVDLKCIQFQDIPLIIEEELEKICEEPVIVLQPRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT22</accession>
    <name>L7JT22_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994067">
        <property type="protein sequence ID" value="ELQ74161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2917"/>
    <dbReference type="HOGENOM" id="CLU_3162572_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT22"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5250" checksum="6C2E508FF28B4CAF" modified="2013-03-06" version="1" fragment="single">VPADGVVNNPKLNIQQVILNVQHGQTARLHLGLRGGCYHSGLLVILHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT32</accession>
    <name>L7JT32_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOT2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT32"/>
    <dbReference type="STRING" id="72359.L7JT32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2909"/>
    <dbReference type="HOGENOM" id="CLU_119160_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT32"/>
    <dbReference type="OMA" id="YIICIPQ"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="195" mass="22830" checksum="411EEEDC11939C20" modified="2013-03-06" version="1">MLKDNQPVKPPKPEYKPHEYTDIRVIQRNLVYIIGIPVKYADENVLKSNEFFGQFGNIKKLVIKNRSMTDQSVSAYITYEKESSAVRCITEVDESLLEGRALKCTFGTTKYCSFFLKNLICQNCECMYLHEIGEKDCALTKEEMCMGKHKLHSFRVVNKGRERIGKKKYELNETLFKYKEVKNFRVPEKINFCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT79</accession>
    <name>L7JT79_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2848"/>
    <dbReference type="HOGENOM" id="CLU_067406_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT79"/>
    <dbReference type="OMA" id="ATEYYAM"/>
    <dbReference type="OrthoDB" id="10470995at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978827" evidence="1">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="253" mass="27419" checksum="EEB4CC65ABA85279" modified="2013-03-06" version="1">MFNFFLLLVLRTYIQAEPYKIKNSRANTYIGLEGDYPTWLPLAKSNTFKEKPSETEGRVLIEVVEISGKVWDIEGSVKNLIFFHEHGGANQRFLVKRSDNGITRILSGDRCITFVKSNNRFEKQPCVDGTVDQEFLIADENGVTVRTPDSSPTTKHMGFMDEDGSDQSMALEMALEAYLGAGGESGGSNALTAATKGFWAAGGSVDPTEIGTTDALLIAAQAYLRSAGVANASKMNASKAMAALARVHPVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTD5</accession>
    <name>L7JTD5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994048">
        <property type="protein sequence ID" value="ELQ74306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2777"/>
    <dbReference type="HOGENOM" id="CLU_142432_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTD5"/>
    <dbReference type="OMA" id="NNGCVER"/>
    <dbReference type="OrthoDB" id="2194784at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="156" mass="18095" checksum="EB264A4D5A6F94F1" modified="2013-03-06" version="1">MTEAQIVHEKKSVESHKNNGCVERVIRTVREAIEKMGVNEMGKTIKEVEDRYNKTYHAGIKCTLEEAWKDITGIAAVENSKDRRYNKLFKKRKREKIAGGQQVIVTQKENLRDKDKIGRFVENDEVIAVRKSDSCLIRKSDGRTLKKRHYDLKAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTF6</accession>
    <name>L7JTF6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994026">
        <property type="protein sequence ID" value="ELQ74743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2325"/>
    <dbReference type="HOGENOM" id="CLU_918850_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTF6"/>
    <dbReference type="OMA" id="YNTIEMF"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="303" mass="34340" checksum="06BEFC37DB0C89CC" modified="2013-03-06" version="1">MMIIVVIVVEKEIVVRIEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDSGKDSDSGKDRDSGKDRDTNDKDDDNIRNSNNTYNKEIKSGRRYKAGYDERGMVNLNGHDSRKGINNDDGNNNDDDNDDNDDNDDNDDNNNDNINDDNINNNNSINSINNSTNDNDSDNSTNPATNANTSTINGTDPFDSPSYDLSRVQQSIDDGFHILTKTNPEMRFNIKRVIPACFNGYESMDEYLRDVLPNVTKMRKKYCYNEFYDISRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTF8</accession>
    <name>L7JTF8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994082">
        <property type="protein sequence ID" value="ELQ74047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3050"/>
    <dbReference type="HOGENOM" id="CLU_2074784_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTF8"/>
    <dbReference type="OMA" id="CPIAVKK"/>
    <dbReference type="OrthoDB" id="10349522at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="13600" checksum="A592A29748F42349" modified="2013-03-06" version="1">MPRLQELDKKNIHFIFFEQENILRISCNGPVTIILPIYKVLSRVFSYLANIDKGVLLVCPIAVKKTKTDTKIEYFIFAGNECVDFALIPDFSFPFKAFNLCGIILFFTLNFCVTEFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTG6</accession>
    <name>L7JTG6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994046">
        <property type="protein sequence ID" value="ELQ74341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2749"/>
    <dbReference type="HOGENOM" id="CLU_2967569_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTG6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6442" checksum="12A60DC01C1E6DC1" modified="2013-03-06" version="1" fragment="single">VWTTSVNGGQNTGAPCTETVREPEVRESKEPSHQLVSRVRAYLDEDGYGELEFDSGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTI0</accession>
    <name>L7JTI0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3019"/>
    <dbReference type="HOGENOM" id="CLU_2661432_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTI0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8369" checksum="AE930BEAC3CCFE15" modified="2013-03-06" version="1" fragment="single">VWFGGRLNIHGMLCILHARDTIDNGSEGEWLFIASDVNNGDNGILRSFAILTISIVIGDEDGVQIFIKIVNIEKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTM1</accession>
    <name>L7JTM1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2699"/>
    <dbReference type="HOGENOM" id="CLU_409499_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTM1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979130" evidence="1">
        <location>
            <begin position="20"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="671" mass="75858" checksum="312CB7879987F749" modified="2013-03-06" version="1">MLLVIALQLSSMLTSETRPRNVNNSVAFYTEQIPSELEYRETSHQVNNAEHVPSTSRTNEFDQLADSNQVLAQSSLIQVQNNQNSAKITQPNTNKPPYPLYQIVFQPIAPKKTEKPEQSSTSSVAEEYLVDNNLLTYLQSTVPNMLLIQQPLNVPVSIALNTHVPSNYMNISDVNPIKSCSTEHIAEINSTVIRNNEFYQLPQNSFDKLLEAATEMRDCDELRLTGDNKYVSADKMVQSSEIISQANNQSPNEKPAAKRINILREKAFSHNIRPQPEQYHTGWLNNAAEQRLDHERPAGLPHVSSKKYDCDGSSTIDSVGRTSVIQKHVQQPLEKKSIHIPTPFCTESITEYCSGQSSYKLNSAETTSLPTKQFTFSDSQELESKEHGRVKRTKFSDSKSITTSVSDVNPGKQDCLASNSSIKTTTSSKAMDNVPFDLMPTKSKIIKRKKIVEPLYNYAVRDCSTPYVDRNCACSHLDISDEQLFCFINELWTQDFLKQLLDWNSPSSCDLTGGIIMNFKNFVVFLKSCEKPKSKETKTKKHSRGSSKLTNPTVDSLSKFEKALRDDSAQISSEQDSKKLACENEILLNDVSHDTSCLDDITDRNNANEMKSPAFLNQEDNNGHLSTIQIKDKNRDFFDNTLDKSEIFLFLTNYYHGNDSWIVKKYILLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTN6</accession>
    <name>L7JTN6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTN6"/>
    <dbReference type="FunCoup" id="L7JTN6">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2649"/>
    <dbReference type="HOGENOM" id="CLU_024251_2_0_1"/>
    <dbReference type="InParanoid" id="L7JTN6"/>
    <dbReference type="OMA" id="NWKMHMT"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF42">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="279" mass="31394" checksum="AFB0418BA62EC088" modified="2013-03-06" version="1">MLFANKILLLQSRDFHDETKLSGLIAIVDKRKFALNTPMKKLLGGNLKLCCSKDRLNYLSTLINEEYNDVEVFYAVPFPYLSFAREIFPSHVRIAAQDCSEFINGAYTGEVSAEMLVDIGVKSVIIGHSERRKLYDDEKSVCKKVMNAFKTGMNVLLCVGEDEVQRRQNETISVVAKQLKSVLECMIEQNISCIDVAYEPVWSIGTGNVPNNKEIEEVISFIRQELNNYNVNGRVIYGGSVSEKNVETLCNIKCLDGFLVGKSSTTDEFVHIARALNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTP1</accession>
    <name>L7JTP1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994032">
        <property type="protein sequence ID" value="ELQ74660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2411"/>
    <dbReference type="HOGENOM" id="CLU_3410805_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTP1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="29" mass="3733" checksum="FD810430C07CC7E5" modified="2013-03-06" version="1">MYRQIRCIQYQMRIKYKYESETLTDKCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTP6</accession>
    <name>L7JTP6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cleavage and polyadenylation specificity factor (CPSF subunit)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTP6"/>
    <dbReference type="STRING" id="72359.L7JTP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2209"/>
    <dbReference type="HOGENOM" id="CLU_1492604_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTP6"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Zn-dependent metallo-hydrolase RNA specificity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="20683" checksum="329EDEE9630E283F" modified="2013-03-06" version="1" fragment="single">VSDKPFIVFSSPGMLHTGNSLKIFKALCEDEKNLVIIPGYCMKNTLAEMLLNGTRTVTLEREYTIKMQVRNIGFSAHADSSSILRFIAKIRPRNVVLVHGDKNRMAKFKRIIERMCSDMEGFDFRCNVFMPRNKCLVDLPGRNEIVLKSAKEINEDEIAIDTEQEGSAVIAKRIRKYVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTQ6</accession>
    <name>L7JTQ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Endonuclease/exonuclease/phosphatase, Non LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994070">
        <property type="protein sequence ID" value="ELQ74137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTQ6"/>
    <dbReference type="STRING" id="72359.L7JTQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2943"/>
    <dbReference type="HOGENOM" id="CLU_536582_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTQ6"/>
    <dbReference type="OMA" id="RMSIWEN"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="508" mass="59764" checksum="6BFEA748B0394414" modified="2013-03-06" version="1">MKKAVEAAAHNVCTVPRLRTHIRSCNKDTFTRLEIWNWDSFTLKDVRKLLKRKLKEPTPIKRIKQRNGKDRIDLYIKNESLRKVQIIVTELIYKTNGFYKILKTNTNAKNTSNQAIKFYKEDNNKNTATWSNLKLWTLNICGLFHKKEELAYTLRKRRPEIVTLQETLMKTMSYRPNIPGYIIIETKMSNQPGARGLAILVKKGMGHKVNKYADDTCFLAASATGKNKDGQNLVILFVSVYIPIPSEQKKAALNRLASFLRREKQENKFTEIIISGDWNDTPSDVLRALRMRLLSPCEDFIAFKARTRWTRNINREGRCIDFGISLNNTIITKQKVLRDVDLSDHYPVSITLTSISMRKPTEKYILNLKRLLDNETKNSIMSDTRWRQTMSLDVEECDKRILELTNTLLIEHGIRKKKCETVSASVSSKTRRAIKRRKIYFRKHKNSNFSWQEYDRLRKAAKKCVEQDRKRRHKNWLIRGVNTFINNQSKAHWQWVQYTNRRREFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTR4</accession>
    <name>L7JTR4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein (snoRNP) subunit-Mpp10p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2404"/>
    <dbReference type="HOGENOM" id="CLU_2962544_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTR4"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6933" checksum="313171372AC32379" modified="2013-03-06" version="1">MYKGEASARERPLNSLLGCDLEFKQTRVVTKPTENDENETLMLVKTRLREKNLITFYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTR9</accession>
    <name>L7JTR9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTR9"/>
    <dbReference type="STRING" id="72359.L7JTR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3300"/>
    <dbReference type="HOGENOM" id="CLU_130128_3_1_1"/>
    <dbReference type="InParanoid" id="L7JTR9"/>
    <dbReference type="OMA" id="ERINMPL"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="91" mass="10392" checksum="6A135B27036E5555" modified="2013-03-06" version="1" fragment="single">RYLHLIQPIKDLLYPTLEEVKRTNKRKKLIPEPNGSFIRVKCASCDAQTVCYSHTQIKRLCGECNASIWYPTGGAGKLAEQCAWAKIRRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTV3</accession>
    <name>L7JTV3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor 1 (EIF-1/SUI1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTV3"/>
    <dbReference type="FunCoup" id="L7JTV3">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2936"/>
    <dbReference type="HOGENOM" id="CLU_170489_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTV3"/>
    <dbReference type="OMA" id="PIDNEKQ"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="91" mass="10328" checksum="56FD99A31F7EC26B" modified="2013-03-06" version="1">MSHELTPIDNEKQIHVRIQQIYGKKRVTTITGIEDEIIVKIFKELRRKLSCGGHLSKDKKVVQLQGDYSSSICDVLGKMLGDVKIVVHGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTV4</accession>
    <name>L7JTV4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein RAD50, ABC-type ATPase/SMC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTV4"/>
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        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2333"/>
    <dbReference type="HOGENOM" id="CLU_547005_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTV4"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:condensed nuclear chromosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:double-stranded telomeric DNA binding"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:telomere maintenance via recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:telomere maintenance via telomerase"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="499" mass="59084" checksum="23EEA75A75662DA7" modified="2013-03-06" version="1" fragment="single">VFIKKFNDLLREIKDIGKVDYRDERFCSICRYSKGTCVDVKESVQKECKTWFYNILEKRKKLKDELQSIKQNMREIVDVRKIKEEIEGYNQEIKNLEVSLRQNLEYDKDVVLRESVKKMEKRVAKVKEDKNVKIAQRKELECQLEDAKAALISETSKMNQLKQQLIQLEEYLGVIENSEQATHHNLNEEEYYKKILDLNKVISDYEKDKFMKNKVREYLKYQEEQQRIHTIKDEITGIKLSIQRKRQEILAINDSEKIKEILSQLKLKDVDIEDIIKGVEKEINTREGANKQLAQNVKEYTLQLEEKIPNYSEIYTHTKILDVVLKDLDKSIKAIEKSVLKYYENKIEELNRNLKYLWSNTYKGNDIDKIELKAEITNSKYSYKLMMYKNDVELEMRGRCSAGQKVIASLIFRLALSITFSGNCNVLTLDEPTTNLDQCNIESLARTLKYLERMSNLQLVIITHDEEFLNLVSKDSVEYFYKVRRNSSCESVIERHSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU73</accession>
    <name>L7JU73_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Vacuolar sorting protein VPS45/Stt10 (Sec1 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ELQ74855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU73"/>
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        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2216"/>
    <dbReference type="HOGENOM" id="CLU_013933_1_0_1"/>
    <dbReference type="InParanoid" id="L7JU73"/>
    <dbReference type="OMA" id="LVHEWRY"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="529" mass="60493" checksum="A64525A4943E9403" modified="2013-03-06" version="1" fragment="single">VLVCGDEVYETINKNAGSCLSAPTSMSLRLITAFETIAIKTSFGQHAQPKFSRVSSITPPETNPKRFSYISMHVHPAMLDIFAPKLKNILAKGTGTKIALFDSYTKPILSSHVPHTTFLKNEFFLFQMLTDTRCRMQGLTCVIFAQPTSIYQIVCELREPKYGRYIVFFTSRVDEDVLEIMARSDTYAVVSEVYEMNIGVVKLDDMLYRVGGDNRMDGIMCVLSTLGICPKMIATAGMKDTVTQIMVHASKFANRGTLIMLNRSFDPYTPLVHEWRYQPMIYEYLGSSNGIVTIDRTYVLNDAFFELNKFLDINTVSANLREFVTTTEKVPVDLSALSTATKTKESLEKHLKLHNHIVKHCVDNKEISEIEMKIIRDNKMSSKQIEKVLSNEKLTREQKCKLVMIYLLRNPHKRNRPVFEKYTKAQQFVKKHTNAAVPTFREHVDIKLAYEPVITSVLGRILKNKIDGSLCTVDTLKVSKPYVIYIDDITFSEYRAISLFFRERNILDYVILCDRIVNYADMLNDDAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU79</accession>
    <name>L7JU79_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994052">
        <property type="protein sequence ID" value="ELQ74297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2786"/>
    <dbReference type="HOGENOM" id="CLU_2326497_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU79"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="99" mass="11221" checksum="37E3A286BCDC4E1B" modified="2013-03-06" version="1" fragment="single">VVNDVVEYLVENAVESEQVRINEGLIDQEVQTTVTSRYGEYNRSSIVKEHVNGNVVDQETPRIISDVEGQVVNQNVVNVNNELRLFLRDQLSLANPKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUA2</accession>
    <name>L7JUA2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2192"/>
    <dbReference type="HOGENOM" id="CLU_2706556_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUA2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="9026" checksum="8937F21E07DAFC0F" modified="2013-03-06" version="1">MSRSFLHLKVKERCFSPRLALNKALFDDTYDYNARCFMMRYIRISEQFTAYYYERLFEEKLVLKSSALHPFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUA7</accession>
    <name>L7JUA7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exocyst complex subunit Sec8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2046"/>
    <dbReference type="HOGENOM" id="CLU_389329_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUA7"/>
    <dbReference type="OMA" id="FFTHFIN"/>
    <dbReference type="OrthoDB" id="2193852at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="786" mass="93864" checksum="E3EB6AF7F13FA8E4" modified="2013-03-06" version="1">MNGDSRVNTILKELMVDWDDLAQADYNPLKNALELNDDSSVVATNFRNFYHKVDAAMAEIIRNKYRGFNDSVLIYTDINGLYRRLNKLILNMISTTNDCMLSLDLDITKIERENVEIKKMRAIQEYALRVDELHRLYVMYDKKLADEDFEFCTETIIKILESELDEVDAVKEMKSVFYHKRKLFLSVLYRKLDEYIFEDNGMKNEMEIVQDIENVIFRERRLLSYVVQLDGLLEFDNHVFYNLKFNFYRKVNKIINTGSELMSVFQRATDLFFAIIKKLCQFSYNLQMDNEENFYGEKYTKFRIFCLNGQQNVKTELKEELLRLVHSYARTRRVFDTKFKVENLIDFVNYEGLYENKYKIYERMVVKDGDKDLYADYTLIKKPSISNLFLFYDVLKGKFKNVCDESKGQDLVREDITKERAADGGVKGTGLHHDKATNQGVHHLPSFKMTAEKIQMEYKMELIHDITRFIKKMLRKEDRNLKHRIVRILNKEFSMERDYKTQRLFFFTHFINYFKPFTGRISFLRNFLWSFEYVTKKFEDNFSCFFRSQVISDSVYVNGRVNENERIFEGFKKQLLIKNIAYDDLALNKSNFDKIVFAILSLRDLINFYELNVRELERIDKNPRAESIISSLQNVYNAYNVSLSLEIILNVFYFFDKFYRDNDRSFTELFRVVNDMKKSLRCLHVEKEQFLYFNVYLLSEMNVSAYFISIFDVLNFYIVRNIRKLKVGNDHELRTFINDLKNMEEMLQGLSLGQVEGFDESFNFFEDVLNGKCTTEEAKLLRSKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUC0</accession>
    <name>L7JUC0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2419"/>
    <dbReference type="HOGENOM" id="CLU_2499470_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUC0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="86" mass="10105" checksum="042520647A0A1E53" modified="2013-03-06" version="1">MSIVDMMMNKVFCYCFNYRMKIRITYLNLDGFNLDEQNVEMLKTFSSLETLIVSSYSVRGDFFLYLPVYLESLELVPTTFPSSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUE8</accession>
    <name>L7JUE8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="1">2.7.1.67</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.1.67" evidence="1"/>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUE8"/>
    <dbReference type="STRING" id="72359.L7JUE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2124"/>
    <dbReference type="HOGENOM" id="CLU_797369_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUE8"/>
    <dbReference type="OrthoDB" id="10550081at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="348" mass="41643" checksum="123DD0961D2C43F2" modified="2013-03-06" version="1">MLFTTNSIKYFKERTKLQICRDVHKFMSDDLIRRIKTALEYDEHRDLMDLLLVVSLGKRTCFSEYNEYYQAQIRRYHREKKYNDLKRLIDYYATFVYTNGAGTISYAFLKFDLTWYKTFLVFYFRRAKKGPALFEHVEAFFKLFVYTKSPVLIDVFNSVPYIDRTHPCVAEVYFYVHEIMCMKECYTCDYKGSFETLMMPFLLKMPALFVKNNHALIYHAEKLKLNNFNYTGIIEYLKDERTLLNGVVDVFGRIHREVRLRSSFKEEYVWALLVLARDNRYESADAVLTVILEILLEENLCGWEEERSESGSDTRVINESVSVGMGCRDYECRQYILKQYTFKQYTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUG0</accession>
    <name>L7JUG0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2112"/>
    <dbReference type="HOGENOM" id="CLU_3052058_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUG0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6417" checksum="EC802E5049CAEC84" modified="2013-03-06" version="1">MDFKDDMESVTEIWPCVVSLEKINSVQNMSDDFYDFLRRVRGIFHDSIKENVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUJ2</accession>
    <name>L7JUJ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Actin-binding FH2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994000">
        <property type="protein sequence ID" value="ELQ74985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2083"/>
    <dbReference type="HOGENOM" id="CLU_025884_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUJ2"/>
    <dbReference type="OMA" id="YFPTENE"/>
    <dbReference type="OrthoDB" id="2196228at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="598" mass="68867" checksum="4835E72FBE068975" modified="2013-03-06" version="1" fragment="single">VCSSVLSHILKHILAKSEISNELNFLQYVVNDPFVAHLLLSLNFLGLITSKVKDRSVIDGLKDTSVMHSHEYTKFLDGALNFCEFSKDKFLENVKREVKKYLADQSVRLAVELKEIERNKTEYIRVCAGKDEEGADESAVSGAENKEKIGDEAAGAIGTNNGVKNALNMRMDERQVVISNRNIENPAGPENIDQSSNLNNKTGIKNEMVCKNKTDIEELTKKMNDTLPISNSIDVKKVGEEDNKMAKPPKVLKKPPRRPPGRAAVKKTNPEIVKWRSKSYKTLHLERNKCEIFKNYDEDKLMKKFTENDFVPFIRKVEKVKIFSEAKETTKGIFPTKKSYALSIALGRVKDADETFIKKIMNLEMVDENVVKQILTYFPTENEIVQIKECEDLGRAEMFYKVVIADIDIFYECLNCILLNYILDRSEIINMIDILQNVVSYILVDEFLAEFVNISLFVVNIMSKCVIEGFFIDNLNEFIRDENKKLFHLILSKMETTYKRNEYLSQAKAINYDLLCVEYEEILALYSKIKGNKYELIENKNVMFMENIDHIKDRFDTLKESYAKLNSYLGKNVDEKGFELLDRFYDRAGVYYKANKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUL8</accession>
    <name>L7JUL8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin/60s ribosomal protein L40 fusion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994039">
        <property type="protein sequence ID" value="ELQ74462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUL8"/>
    <dbReference type="STRING" id="72359.L7JUL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2609"/>
    <dbReference type="HOGENOM" id="CLU_2086611_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUL8"/>
    <dbReference type="OMA" id="SARAEHC"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL40" evidence="3">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="117" mass="13352" checksum="642038BD04414FE2" modified="2013-03-06" version="1">MRIILHHSNSTKMLDIPTYNHLLSFAPDHLLTTNGMLLTPQNFQFMAPFSHVNATVRLMGGALSEDDRALAAKRLNVQVCRKCYARLSARAEHCRKRACGFSRKLRAKKKIRETSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUY8</accession>
    <name>L7JUY8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1959"/>
    <dbReference type="HOGENOM" id="CLU_2905762_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUY8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7336" checksum="7003FC6E6DF1B21E" modified="2013-03-06" version="1">MISMETIFEIESTEEQDDTFVIERSIDYGENEENRRLTKAEIDELKSEIERVSKIINKKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV02</accession>
    <name>L7JV02_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV02"/>
    <dbReference type="FunCoup" id="L7JV02">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1857"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="InParanoid" id="L7JV02"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="283" mass="30452" checksum="D3C21143DAB29CD3" modified="2013-03-06" version="1">MSKCPGIHSERAGQAEACASCPNSTYCQQTTNSSTITKSRIARNTAGKKIIAVMSGKGGVGKSTMCMQIAHALKKCCVLDFDVSGPSIAKMSGTENAIITNVQDTFVPVHVHGTCIGVVSAYHVNEWHSVEQLYQPSFISSFLINVLSNCNFDTYTHVVIDTPPGITDEHLIISNYVDAVCVLVSTPGVLAVNDLVRQIDFCERAGVKVLGVVENMREFVCECGCVVPMGTVDVREVCLRRGVRYLGGLQCVKAVGMFADGGMVYEDALFAGVVRNITDELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV44</accession>
    <name>L7JV44_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1885"/>
    <dbReference type="HOGENOM" id="CLU_1210532_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV44"/>
    <dbReference type="OMA" id="MYFVNGM"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="229" mass="26071" checksum="D0C746D697A1992B" modified="2013-03-06" version="1">MPVKIYDIKKNVVNDQVESIRNMYFVNGMFLVLIGALLLLNSLLFVPLGWTIFTNAMPLILAVYIYMMIILQASTFLAPYLELYGGEEFSTPAMLAYFVGFMALLAPIVYILSLYYTYNTALCLLTTVILMCNALNMMSKNNREVYATLIVNALYCGLMVLFTIIALMFQLNRLWVCLPIIVVYALDQILKSADRPISWYPIEKKNHLHGCPYCWQASPFSCSLLTCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV49</accession>
    <name>L7JV49_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993968">
        <property type="protein sequence ID" value="ELQ75358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1701"/>
    <dbReference type="HOGENOM" id="CLU_1797906_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV49"/>
    <dbReference type="OMA" id="MLYNTEY"/>
    <dbReference type="OrthoDB" id="10344839at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="145" mass="17030" checksum="533E30D0C075ECBE" modified="2013-03-06" version="1">MREQDEEKNLQKALIDIAEDTNSTCESADEYMLYNTEYDDELASVNKVKVKEVLEKLKENDGEVYEINLSKNTILGDIVSYWNSKKKSRDKMEKRGMNKKILEEKNCQVRVEVRNKVKICNNGSNKRVKAKDKEYFKTNFCGNWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV89</accession>
    <name>L7JV89_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV89"/>
    <dbReference type="STRING" id="72359.L7JV89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1828"/>
    <dbReference type="HOGENOM" id="CLU_002173_4_5_1"/>
    <dbReference type="InParanoid" id="L7JV89"/>
    <dbReference type="OMA" id="FRWHELE"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="115" mass="13115" checksum="C31F2DF05F0A0888" modified="2013-03-06" version="1" fragment="single">VGSNVINVSLLKKTAVYSGFTEDSHIVKTFWKIFEEYSLEDKKKLLMFITGNERVPVTCTENWKLIIVRNGCDTDRLPSSQTCFNTLLLPEYSSEEKLKNKLGIAISMTKGFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVC9</accession>
    <name>L7JVC9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vesicle coat complex COPI, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVC9"/>
    <dbReference type="FunCoup" id="L7JVC9">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1637"/>
    <dbReference type="HOGENOM" id="CLU_007565_1_0_1"/>
    <dbReference type="InParanoid" id="L7JVC9"/>
    <dbReference type="OMA" id="IWNFQSK"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="133"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="4">
        <location>
            <begin position="529"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="903" mass="103801" checksum="7DAAB05B4ED50E21" modified="2013-03-06" version="1">MQALNIQDEIKSPRVKSVCFHRSRPVVLLALHNGEIRAYDYTLSSFIHKFLDHDGPVRSIQFHPQNDIFVSGGDDQYVRIWDYASRTNVKLKGHTDYIRCVRFHQNEPFLLSASDDRTVKIWNFQSKKKIRTLAGHTNYVMCAEFLHDKRVVSVSLDQTIRVWNIDDGTSEIVEAHDKGINALSLLFNNGSFAIFTGSDDRSIKMFNSDLVSTDSFNYHSKAVTALLTFNKVVISCGEDGLLFVNENKKTRRIEREGRFWCLARNSENVIVAGHDESFVIFKLKNDLVFDENYVIRDSRVVNYRNERVVDLKKEAKSICSQGDMLIVNYAHRFEVYKARDQRLCWSETGNAAFFNDLIVCSNKGEFHTYLLNGQVKDECIFFLAGRVVGFKTAFFVLNEKKIVMVNAKYERKSTSVPFVVTNVYYSEKPEPVCVVTGRNDLAILDNELEIVRHTNDMTRILSVVISDGLVFYTTEKQLRYVFRYSEGVICSLNSFYLARMYKKDERDMCLLVNDAQTVEREVNLDEIKFKLAVLNNDSDAIASHIGNLPGMAVVNFLRINGRGDIALPFIHERAQKFKLYLSMGDIANAYEIANDPDEYAQIYQAGMKNVELIDKNYEVIEGCVQRMKDERKLFMFYLVTGNDEKLRAMVADDLNVRLLRCVYLDDKNGVMEMLRDGGNIVDNQKMIEDELAEESDGDEDKYYDYDGENKLYHVQRLNERRNFVVEGLNAEKEFDSAMACIDAGKAKDALKTLYTIFYSLADSLDEKKRFLIGRYVAGLESERKRKKETDVKRMLERAHFFYHLELLPKHRKIQTENYVAVSYKNGNYTSAKLAAEQLDDEFGMKVRKSKHEGDAIEVGKGVFCVDEGCYRDKGRRCSFCGCFNAEGECGGCYIGVVSDEVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVL0</accession>
    <name>L7JVL0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2301"/>
    <dbReference type="HOGENOM" id="CLU_092549_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVL0"/>
    <dbReference type="OMA" id="YDKEFFY"/>
    <dbReference type="OrthoDB" id="2195889at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="23004" checksum="54D569CEBB28324C" modified="2013-03-06" version="1">MLKKYQKINSLLVEIKTKLEKLQEHSNNLKLFNIKIKALNEAFKECSLTIENIKEEKDATVEEIQMEEFDEQSDYEYNTSIVPDEHDTSYNPMYDNTNQTNSHIIESKPAVKERSLQSILIYASTLLPKDQKTQQNLKKIVSLLYDQKEMSLNNIVTICKVPKYRAVDILGKLSGAKRPIVSKRYDKEFFYTLVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVP1</accession>
    <name>L7JVP1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tub family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVP1"/>
    <dbReference type="STRING" id="72359.L7JVP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1667"/>
    <dbReference type="HOGENOM" id="CLU_1171375_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVP1"/>
    <dbReference type="OMA" id="MNAYKTL"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="231" mass="27416" checksum="4A4C3E9FF86F9330" modified="2013-03-06" version="1">MNSQPFSFNAFNSDLLRLPPEKFKYLISTSRVNREVIIGGKVLKISNYSFSYHLELSERRELLVMNAYKTLFGYNIYTFEKNQKLRKIGWLKMNMKKNEFVLYEAERDTIIIKYANVMCDHKLFHDIEVIYTVEGDSVLERYRNNEEDKIIRLVNKKPRYNKDRDLYTLNYNNSSIMPSERNFQLTHPKIPSHINLSFGANSENDYRLNYTFPWNALQAFAISLSALLFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVP7</accession>
    <name>L7JVP7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1486"/>
    <dbReference type="HOGENOM" id="CLU_1442016_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVP7"/>
    <dbReference type="OrthoDB" id="10616123at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="188" mass="22160" checksum="C652F9FE33D16903" modified="2013-03-06" version="1">MYYEYLKLSSRTRVLEQKFFSARVAQFHKLYASLSDQIAEKDERIDTLKKQTTELQHKLEDLEEQNAEWGTNNNKLQAELDIVNKDVKRLQAISVEKERKIEKLNAEVESCRKEGNAASNAQIDRLERELEKLRKENAKLADRNKELIDKNKKLGNDKVLGKKNIVLEKNTRRLLTNTMKLRKNTMNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVQ2</accession>
    <name>L7JVQ2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVQ2"/>
    <dbReference type="FunCoup" id="L7JVQ2">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1491"/>
    <dbReference type="HOGENOM" id="CLU_1462333_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVQ2"/>
    <dbReference type="OMA" id="CEYTILK"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="20810" checksum="96C96F03829F5099" modified="2013-03-06" version="1">MVKSSSPIFILLSSFVLNNEPVSFLTFFIIFLIGLGTFLITFSHDTLNLPQVLPILFASLVSGIRWSLIQRYLTKTSIFTFIATINLNISIILLIMAIYFEGLPVLNMHSFVLIVVLSVISFFLVWCEYTILKCFSCVFLCVLGIVKEMSVVVLSVYVGKVRLEGVNWIGLVLSVCGLMMYGMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVX4</accession>
    <name>L7JVX4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993956">
        <property type="protein sequence ID" value="ELQ75465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1586"/>
    <dbReference type="HOGENOM" id="CLU_2078769_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVX4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="13267" checksum="A593D0A6DADA8D9F" modified="2013-03-06" version="1" fragment="single">VSLNNAVVSKQRVLRDVDLSDHYPVVASLAVKHITAAPDKLIYDRLKLQLIGKTAAKILSDRRWLTCRSGDVSERAKQLHLLVEEISLEHGIRRARCERTLEDTVLPTTRGPSTMRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWA4</accession>
    <name>L7JWA4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1717"/>
    <dbReference type="HOGENOM" id="CLU_2783033_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWA4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9008" checksum="A36A17E9F903ADDF" modified="2013-03-06" version="1">MYESTNKSLVALCDILRFTSMVHQTKLRFWPCRTCLLGELCRTSMNRKPVAMVEALAGQEKGFIIFAVNNEQVGKICCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWC8</accession>
    <name>L7JWC8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
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        <property type="protein sequence ID" value="ELQ75356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWC8"/>
    <dbReference type="FunCoup" id="L7JWC8">
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    </dbReference>
    <dbReference type="STRING" id="72359.L7JWC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1699"/>
    <dbReference type="HOGENOM" id="CLU_013572_1_0_1"/>
    <dbReference type="InParanoid" id="L7JWC8"/>
    <dbReference type="OMA" id="NAPNMLE"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="110"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="287"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="402" mass="46054" checksum="5B76F4B05F4CE901" modified="2013-03-06" version="1">MQNEVDHVKNENSDDSYSAVGIRAFVLDNPAHDPSNNVSLMDHLNNELQNFLNFLRPSDEEMVLRRLMVKRIKKLILSGLRQMRRQQASASGNDSSYNVFTENMDIKIARALQSDAERRAEKSDTERCDAQEGRKRPGNRVKCIGSYATGLYLAGGDTDLSLLTEEEDALEKLSHFLRKSPLILRRSVIFISKARVPILRFVDICHFKYDLSLNQEASLAHTKFVKDILHKQPAIKDMALFLKQFLKCRGLNENRRGGLNSYAQLLMIISFLNLHPLVQNQVSIKANLSVLFMDFFEFYGQDFCYDKAAICSSGYKAKTSNSYLSIEDPTNSSYDVGCLSTKMNVIKEVFMHAYKTMSALARERVGDKYIALPLWVKVCDSEAIWRDNIPRFYKKMIINREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWF8</accession>
    <name>L7JWF8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993994">
        <property type="protein sequence ID" value="ELQ75082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1978"/>
    <dbReference type="HOGENOM" id="CLU_177947_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWF8"/>
    <dbReference type="OMA" id="MCENEYL"/>
    <dbReference type="OrthoDB" id="2186985at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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        <property type="entry name" value="DUF5101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17031">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="12960" checksum="7EDF5BD89E9DB90F" modified="2013-03-06" version="1">MRIPLSEKNTRSKQSQMHKQHKQLTDKQRVLNFLCDVTNTTNDHSLKYDLMKCVETIEGKENVEYVELKGALREALEENERLEQDKVKLMCENEYLKEMMDKKKDPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWG3</accession>
    <name>L7JWG3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1689"/>
    <dbReference type="HOGENOM" id="CLU_2874103_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWG3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="64" mass="7467" checksum="8E6DB8D38B78FBB1" modified="2013-03-06" version="1" fragment="single">VLGEMLNCRLNKFFQKRFKMVEHKDLESTTDMNNMKVQSFITVLPQKYVIKASKAAFVARNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWG8</accession>
    <name>L7JWG8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1287"/>
    <dbReference type="HOGENOM" id="CLU_083362_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWG8"/>
    <dbReference type="OMA" id="DALWDIK"/>
    <dbReference type="OrthoDB" id="2186465at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="311" mass="36175" checksum="A64BF2DEE6AD2D88" modified="2013-03-06" version="1">MFYYTEDQMMSFLTLKEERPEDFDTTNPFYSLDTMPLKVLSSLDEREQAIYEERRLNSGISAIRKTQVIKRREREYSDALWDIKIKEKNEGFFDSQGNYIVEGGIEHEYEEEVCWLMKKGRCMLGPFNQKEMLEMHERGDLAGSLIRRDVDKVFVEYEQLKDVPCVFTGNMDERMLNEIFTNAHLHKKEGSATTDMPFYDACTQMVDEPPPPPEKKKTLADRLEECTRTIALLKKRNLTIRLYDIFVCIKGMKKDAAVQKMASITGLCTADNAELLDAFLEEVGVQVCRDVDKDGFYIKVQSGKRNVKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWK0</accession>
    <name>L7JWK0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1260"/>
    <dbReference type="HOGENOM" id="CLU_641211_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWK0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978858" evidence="1">
        <location>
            <begin position="23"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="428" mass="49484" checksum="FD008E0E4CC19EE3" modified="2013-03-06" version="1">MKNIMEMYFIIILLLLLQLIHGTNETNMNDKNHGDILLKKDSTDSFSGKDENISIWQELIGALTDLVKDVKEITDKSRKLIELSKKDPFETNFKLTNGNLSQFFRVLYSKYQINQNMIYLEEKVHTVVFKQELNNLCAYICRDNLETVAMEITCLLTILDALYISYTGINSMDQAFIENFSQKTMEIAFKVAGIKLLPNIVEISNEKWDLIVKLLITLDDMKSKLLQVFKKWEVDLNRLDEQELSRVDILIIMSFVKEDLKNFELETVNSASSSYFIINDYQSTPDTAALYRDNSLEFMAQLNLQTNIQNIIRMSLNGSIENNEQMSRRFDGNSRTGFLSTENMLEPQRSYEFSCSITSNPVTCEYKGHGDQLQPSKKRAKYDNSCELSSLKTFNISSHHAESCDQDQPVLPSSSYQCVEMEEDPWYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWP5</accession>
    <name>L7JWP5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993905">
        <property type="protein sequence ID" value="ELQ75903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1126"/>
    <dbReference type="HOGENOM" id="CLU_2747201_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWP5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8232" checksum="575042A6298CDE9D" modified="2013-03-06" version="1" fragment="single">VINNVMITMNETLERNNQGGTLRMECFIASYPLLRYVLGCCVERGVSKERINVKDGMNNIIIIRKDYNVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWS6</accession>
    <name>L7JWS6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWS6"/>
    <dbReference type="FunCoup" id="L7JWS6">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1278"/>
    <dbReference type="HOGENOM" id="CLU_060400_1_0_1"/>
    <dbReference type="InParanoid" id="L7JWS6"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="8">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="10">
        <location>
            <begin position="212"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="267" mass="30070" checksum="3B54A69C12ED8A80" modified="2013-03-06" version="1">MVRGPRKHLKRLAAPKSWLLKKNVGVFAPRPSTGPHRLQESIPLSLLLTDKLQYARTGKEVGNILKERMIKINGRIRTDKRFPVGIFDVLSIPKTGEHYRLLYNVAGRFILHQISEEESKFRLSIIRKKLLRKGKVPYLYTNDGASFSYCDQDIVPSDTVKVDLETGRISDFLHISVGNLAFIKKGRNMGCVGVITNIEEKGVEDCKVYLVDKKGRVFATRKVNVCVIGPDGNSWISLPENEGVKLSVFDESNIRYEGETLKAAEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWZ8</accession>
    <name>L7JWZ8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWZ8"/>
    <dbReference type="FunCoup" id="L7JWZ8">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1444"/>
    <dbReference type="HOGENOM" id="CLU_043845_0_1_1"/>
    <dbReference type="InParanoid" id="L7JWZ8"/>
    <dbReference type="OMA" id="VWFSHNG"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="313" mass="34976" checksum="A06D7A4EB256B0A5" modified="2013-03-06" version="1">MTSGSQINFTLHSRPITHVQYNYDGDLIFACSLDSKISLWDTDGNLKGTYDGHQGAVTCMDQTEENLLTGSGDRSVILWDITTGKQQLSMSFKSTVKSVNINDNNLLICCDDSYNNKPAFNYYDVRSNSLIFSLNLDFIITSSILKDKFCIFADTEGNLRKFDFAKNEAVQNSKIHNSKINEIKPSPCAKYYVSSSNDATTKIFDSKLKEIKTFQSTEPVNSASIFPENNILVNVGGIPARDVTLTRGKRKFDVNFYDIVREERVGFYSTHFGTINTVDVARDGRSFASGGEDGIVIMVKMGEEFYSAPFTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX23</accession>
    <name>L7JX23_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1774"/>
    <dbReference type="HOGENOM" id="CLU_1078479_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX23"/>
    <dbReference type="OMA" id="CYIEDYI"/>
    <dbReference type="OrthoDB" id="10308503at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="258" mass="30911" checksum="CE3A499BE6E9456B" modified="2013-03-06" version="1">MTFHPDYKTLDLTQTVESSSEEHRIYLVRNAIYKRNPPHLNKSIIIEYFCYGFERLKRRCFKPQRKRMRKNKHRAQKNYTYNIYRNNKVIFRTMPYLMTDDEDQVLEWVHMFKNAAQEACWTEDAKKQYILELTSNTSQPTLKRQACSDDMLKVLLSNVFPSYRRGEIVKKLLTTKQKDFCYIEDYINEIKHLTSKLWISRGGGVEPDEKTLDEYFKIGLDMDTLVYLEMNGLYGIKEISRNLIDLERIITDEIRSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX46</accession>
    <name>L7JX46_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Histone acetyltransferases subunit 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1750"/>
    <dbReference type="HOGENOM" id="CLU_957123_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX46"/>
    <dbReference type="OMA" id="TKNRYED"/>
    <dbReference type="OrthoDB" id="10310782at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="299" mass="34878" checksum="0BD43926A7F8613E" modified="2013-03-06" version="1">MIPPYWRPMEFIGDDNEQQNVVKIGHKEQSSKTTVQDSLNGKIQNINTPNPNANKPSQSEVSYDDFNSFLQDFFSDITKDAFEEIVSFPVINVEDINVNLYKSKCIYLSQNEVNIDDLLVSALMSENNEESFVTKNRYEDDILFKPIKESETVVSEFFEKCKNFCEKIDLRNINIQEEDKIMGVLKKQIGINNGRRKNLSDILEKKLEVLSILKFLREIDKKIEKIAFKRIKNKRKKKSEDNIQQLLELIMERNQFYDAFKNEIETSLDVLSISHSIFNDENIDITSFGFAPKNFFPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX57</accession>
    <name>L7JX57_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol synthase</fullName>
            <ecNumber evidence="10">2.7.8.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="10"/>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX57"/>
    <dbReference type="FunCoup" id="L7JX57">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1135"/>
    <dbReference type="HOGENOM" id="CLU_067602_2_0_1"/>
    <dbReference type="InParanoid" id="L7JX57"/>
    <dbReference type="OMA" id="VTGVFFY"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="190" mass="21815" checksum="B7CA84C987229352" modified="2013-03-06" version="1">MNTAVLFYIPNLVNYLRLLLIISSIYLHGNLFLLVYTISSSIDLIDGTIARSLNQTSKLGACLDMFTDRLTTTIIVCKILERKRSKSMILLLFIDLLSHMLLFTSSMAVNVSHKEPILSMLKVYYQKVVLVLLCVGTEVYYVMKYLDTYKKVNKNVILLFYTFLIVKSFFHFLQLIEGMCRLSDLDGGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX89</accession>
    <name>L7JX89_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase, Non LTR Retrotransposon</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="JH993876">
        <property type="protein sequence ID" value="ELQ76088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX89"/>
    <dbReference type="STRING" id="72359.L7JX89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0941"/>
    <dbReference type="HOGENOM" id="CLU_330808_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX89"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="262"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="867" mass="100990" checksum="2A2048FD85405E81" modified="2013-03-06" version="1" fragment="single">VRKKIIFDRTRITQNLEVMSKIMNNRRWEISNDLSLAEKYKSCIKAINDISWEYHLKKEVKSKQNKCYSRRTKKLIEKRRQNYKGHKKPGFDWLSHEELTDQADKQKKRDRKENKRKYLMRGIKSFLQNRSKIHWNWLKTIARKRRPFVAKPVIDRDKNELVFGTKEIGEAWRSHFEKLSKDDDGFSKDREYWKTVIEPAAQTLKGCDDPITWEEVLRALEHSSKGKATGTDGIPIEFYKVLQRDKNRESPFGNFVFQLITEIYAQAKVPEQWNEAMIVPVPKKGDLHNMDNYRGISLINTLCKEVVKIITEKLNRICTTNKILRDEQAGFRKLEECIAQTTCFYEIVKRRSLKGKPTMALFLDFKKAYDKVPHEGLFAKLRGYGFSGRILDFLIELYRNPKASVRIGDERSDTFNYQMGVKQGCPASPTLFNLYINNILEGITGVGIGNGEQVPGLLFADDAVVFAESYDDMVHNMEILEDWCDKWKMDLNISKCGLMVFNSNEQRAIKYKNANIPTVERYRYLGIPINRNLDLKTVINDRKEKAQQALMIIRPLISRIEIPLPIRVTLIKSVLIPTATFGSELYGMSSQRTAPIQRVIDKAVRCAMACPANYCRLTAYEEIRIECIDIRAAKARTRAFIKWRNSRTTISKVMKTDFKCPKTTWYTGTARWIRRLLKNDTLNSTQEGVKKVEDALTTGKYARSKSKIREKRRKLVFGSSISNWKETVKNYRVNRGWHVLTKIRTGTFMFGYRLAKYGRISSEYKKKCIACEKHGREDGIHLLWHCSKWEKEREECYRGFNNSDDQKIRNLFDKNSQDELLEGVLLGGGLNVDYINNLRISVTVATATYLERIIGRRAEIINNLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXE3</accession>
    <name>L7JXE3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative alpha-helical protein, potentially involved in replication/repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXE3"/>
    <dbReference type="STRING" id="72359.L7JXE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0899"/>
    <dbReference type="HOGENOM" id="CLU_127203_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXE3"/>
    <dbReference type="OMA" id="EYERISY"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="126" mass="14955" checksum="2309C78202B66E52" modified="2013-03-06" version="1" fragment="single">VSTLKEHKLLKSLYEQELERVKYILTDYLRVRLIKLQNNFYVNTEYLSEYEKVFYQKLVEKFKEYDIFTEQNEEYVDFECVGFIALVDIGKVIIDGNSVDVLAGDFFVAQLADVKHLLLDRKIMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXJ8</accession>
    <name>L7JXJ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0865"/>
    <dbReference type="HOGENOM" id="CLU_2279414_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXJ8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="102" mass="11753" checksum="60F99974F97AA2EC" modified="2013-03-06" version="1">MTVYYRTKPIKPSTFLHPMKIDNLKALYHSKLTPTNYHKYAKTLVQLNDPSLTNKLLRLASIDTDGNRANAVLTEIFEGIDAFDEIEWQFLGSVSVSERNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXP6</accession>
    <name>L7JXP6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0930"/>
    <dbReference type="HOGENOM" id="CLU_1918541_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXP6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="132" mass="15030" checksum="D31FC82C64F00A18" modified="2013-03-06" version="1">MLKDYSVYKPSSHEYSNLLDYQHLENYVLGGVTTNDMKYFLETSMCTGRTNDYIDETLNTFRMANASLLSEIQNDWWSNGIDIWSANLPETFATDIDGGPSTSNNFDYSCEKTNCTILSHETNTTKRHVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXQ6</accession>
    <name>L7JXQ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993944">
        <property type="protein sequence ID" value="ELQ75542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1500"/>
    <dbReference type="HOGENOM" id="CLU_676501_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXQ6"/>
    <dbReference type="OMA" id="PSCYITL"/>
    <dbReference type="OrthoDB" id="2191583at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="407" mass="49073" checksum="C3671C6AB02085D6" modified="2013-03-06" version="1">MSRKIVFTKNIRIEDLKSISELVNTVKKGEVYNIPRFDDPSCYITLLRQIFFFIGAKKYKDHRNTMLLQIFDTCSINLDTVKSELVNFINDKRIFFVVKAISKNVNDKKYFYENLAEHKIDILSSVRYAREIEFLSSINWAALDYLYIMDKLEQDCKFIIDFLRHDDENVQEKALSMFLERVKHKKNDFNEKLWRKINRKMLKILYTRGNLDKISLMALETLCYKYLSDEDLERTQKLCHLDPLKFLVRAPLRSKITKEILLELLKVSNWSVHTYDNITIENIIYSNMHLLNEEDVFYIVELPFTEYLRDFFLKLNIMNYKIFVSLCIRVANEPQFLNCVFLLECMKIYKKCDVMDEWKSNKKMERLLLRAYPLIMKDRDWYLRLLAKMETVWKGECLLIKKYFKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY00</accession>
    <name>L7JY00_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0754"/>
    <dbReference type="HOGENOM" id="CLU_723986_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY00"/>
    <dbReference type="OMA" id="ETERCHC"/>
    <dbReference type="OrthoDB" id="10677330at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="382" mass="47201" checksum="905E075C809CFF58" modified="2013-03-06" version="1">MILIFIAYITNVFMTSEGNHVNNKTSKKHVLRAKEYIELEYESEGKRGILKIDGKMRERHKDIPGYLMARLSFEACEQVMKVLLRYVNEFAERGKIIEQEEKLNEKKRIKDEAKLESKISNLEILTVEERQKAEEMRLAEEARKAEEARKTEEERKAEEERLAEEERKAEEERKAEEERKAEEERKAEEERKAEEARKAEEERKAEEERRVEEERKAEEERKAEEARRANEERQKVEERKAEEAKKVEEARKAEEMRLAEEAIKAEEERKAEEARKAEEERKLRKRERLRKRERLKKQGRLRKRERLRRRDGLRRRDLLRKRERLKRRERLRKRERLRRKDLLRKREKLRRRGLLRKREKLRRRDLLKRRERLRRQKRLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY23</accession>
    <name>L7JY23_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY23"/>
    <dbReference type="STRING" id="72359.L7JY23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0839"/>
    <dbReference type="HOGENOM" id="CLU_1511648_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY23"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="87"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="178" mass="19936" checksum="23FF06103C18CB70" modified="2013-03-06" version="1">MLNEENAQTYEQEKEASRELLRSLDIDTHRMDEVQPKDALTFSNAMVQDNTLLSTADFSSLLVSEEIKNALYMLGYDRPSLAQLSTIPHILKGQSLLFQSKSGTGKTISFVVGALQNVVKGKGVQVLLITPTMELNRQTTSIFEKVGGPLGIRTFMAMRGERVSLWTRRCWSAHRVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY83</accession>
    <name>L7JY83_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0579"/>
    <dbReference type="HOGENOM" id="CLU_2984812_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY83"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="6872" checksum="EA335738CF13A0D6" modified="2013-03-06" version="1" fragment="single">VDTVDWRETNVWWLFVDGMMSMACGWLLGDDIVMDKGERGNLIYFVFITFFNTSRTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYA9</accession>
    <name>L7JYA9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine protein kinase and endoribonuclease ERN1/IRE1</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYA9"/>
    <dbReference type="STRING" id="72359.L7JYA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0606"/>
    <dbReference type="HOGENOM" id="CLU_331265_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYA9"/>
    <dbReference type="OMA" id="INQPFLY"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978975" evidence="5">
        <location>
            <begin position="20"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="345"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="7">
        <location>
            <begin position="738"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="865" mass="100712" checksum="4F4BB61A0AE0962C" modified="2013-03-06" version="1">MCTPFFIMFFLLFAKYVYCLYVFETFNSNLIFVDETTNEQWTFSISNMVDEYDNRSRLISGSGGNTGLTYLKTNELALKITERVPSSSNDVEAEDNLESINTTNESDKKVNNYEKKMEIRIVNGGTKSISEHNGDHSVNYVMSDENGTSRKLNTPSILSNTANTLSKIENYADGRLYAKSKERIDSFGFTESGKIYCIENECIMYLTPRLNDIINQPFLYRNVLITASKRNISYDIKTQNSTLYIIIGILYIRLMDVNSKYTRILKFYNICAPFFSVNNDIKVQYDVFEDGQNRFTLYEPIKDVYKVENFKKAYFFRKILREPPEINDRLCTDLKILVFLLKTLFVVVLFLHRENNVKVNRTLRVDKGIKYANGVFNKRNVMVKIYRKTDIRYLNELNILGMLDVPCFIKYTYREEKKQECFFVVDECGRNWQEKACLDGTAQPSSTNNSIMHDDVFTFSEGISNEVNVRSADFDENEGSSDELNGTRKDVSMHSMNASELENTILSNKTNTHEIGDNVNEQLGTFLKLVRVVQILHDKHIAHCNLALVNVFTRNDEVLLGNFEECFFDTEDEHENGRNERCISNHTPNNGDMPEDNKTAGDESVAADYTERKLSDRKFGDVLRHPEEHKLEFGLGTENFRAPEIIKYNVFDEALDIEKCQKADVFSLAVIWHVTAFGQHPFNKDNYKVEDNVIHDNYSLNSNIKGPLLDLMHHMLKNNYKERLSIHSVEKHPVFWDNEKTYNFYATLSDILENKNEMSYKIFCRLERNKNKVFSGNWANRLDKVMKDEISVHRIYNFNSLKGLLRVIRNKGRHYQELAGEIRQIFKSFPDGFVDYFRMRFPNLLMVCYYSGKVAASEELLENFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYD5</accession>
    <name>L7JYD5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vesicle trafficking protein Sly1 (Sec1 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYD5"/>
    <dbReference type="FunCoup" id="L7JYD5">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0510"/>
    <dbReference type="HOGENOM" id="CLU_016216_4_0_1"/>
    <dbReference type="InParanoid" id="L7JYD5"/>
    <dbReference type="OMA" id="DAHMSIC"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="487" mass="56044" checksum="5FA3F7CECFA53719" modified="2013-03-06" version="1">MIQNLQKAKLSEFLKSSTWTVLILDDTTFPIINALFRFTELRRLNITTIFRLENTRENVTASAIYFVHSKNLHSIVSDVIARTYSSYNLNFIDCVSRDGLEMLAGTLSERRLALKVESVWDRHLNFLALDNNVFVVGGGVHEMAAGLFSLFFNLDNEPFIVSGDENVSGDKNVSGDESVAELLYKKMRNNLVRKKDRRPLLILFRRENDVITPLEHNWTYAGLINDVLSLNINTVKYTKDDRPCTYTITPDDTFYATNKYEKFPVVTERIEKEHLNYKKEIGKKNYDIAELNRSNEMIDAHMSICLNLINEISDRGYDEYYEMEQRNASDDQIYKMVEKGTVEDVKRFVCTLLRKGARPEVIEYIMAKRGITQQFVEHVVQRIKIEENTLLKRATNILSKIINVDTSTPLSVYVGEIVAKARKGELRVMGGRKVYYEEVAGVYVFVVGGGCYKEIDSLRRMDRDIVYGCGEILDGRRALERIESGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYI1</accession>
    <name>L7JYI1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0551"/>
    <dbReference type="HOGENOM" id="CLU_1138689_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYI1"/>
    <dbReference type="OMA" id="HDSINGC"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978895" evidence="1">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="244" mass="28343" checksum="65DC4104AFEA5477" modified="2013-03-06" version="1">MDHLISHIILHIILKTIQCSNFYGMQPEYTENSSVTNPETRTTNDPGCREAAYTSTQANEVKNTHNRTIKLIRAYETTHKYMFSVRASRLVGFKRLCDIINFTWRDCDQNRPEKFTIMLSNMNNNEISNHFKELKKLCINCSMSERKHLPVKALNKGKQRPMSASAEKMIEEYEKFMRHDSINGCIASLAKYSDTILSLSARERTVVAFKEFFMLFGDVINVKSYLNPENADEVTTIEIREFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYM8</accession>
    <name>L7JYM8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor SPT4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Chromatin elongation factor SPT4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993869">
        <property type="protein sequence ID" value="ELQ76146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYM8"/>
    <dbReference type="FunCoup" id="L7JYM8">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0880"/>
    <dbReference type="HOGENOM" id="CLU_138052_2_0_1"/>
    <dbReference type="InParanoid" id="L7JYM8"/>
    <dbReference type="OMA" id="NCKNANS"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="7">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="105" mass="12024" checksum="56DA46F56CC749DF" modified="2013-03-06" version="1">MLTEKSYTSRKKYKACMLCSALIPVQELKKEGCKNCKNANSTSYNYKGLIGVLKKGGWVEKWQRIDEYGEGLYAMTVEGDPNEEDVCAIEEEGKTYFDRNESFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYW2</accession>
    <name>L7JYW2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0538"/>
    <dbReference type="HOGENOM" id="CLU_1929073_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYW2"/>
    <dbReference type="OMA" id="NVHFNQR"/>
    <dbReference type="OrthoDB" id="10317163at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="131" mass="15679" checksum="66E97408B884E1AA" modified="2013-03-06" version="1">MKKIFVRESNRFLNQLKLYIEGKASLESLVKLERDLSLIYDNIRPEDLRNKIFEYHLNVYETILQADLHQEYKSIDIDKNELIHYAAYIGLAQNVHFNQRGGLPPFPVKEMLHYDKESVEEKEDEEEVFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYW6</accession>
    <name>L7JYW6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993897">
        <property type="protein sequence ID" value="ELQ75952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JYW6">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1080"/>
    <dbReference type="HOGENOM" id="CLU_226997_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYW6"/>
    <dbReference type="OMA" id="WIECAKE"/>
    <dbReference type="OrthoDB" id="2191645at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK-related kinase FAT" evidence="2">
        <location>
            <begin position="2316"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1716"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2092"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1734"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2105"/>
            <end position="2124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="2764" mass="317979" checksum="3D0F0B689E837858" modified="2013-03-06" version="1">MGIKEKMIMESSTNEKMKKLRQWLRNENSIECVYRSSQFSDSFLSFSIQMLTELPYNKDAVGFVYDDRTLILKLVFRLKYTSYPEIEKLVDVLCISLKEDNLSNRGLIIKCFSILVRKFSLEPHILKKVFTSVDLFIAEIFENVEKARNVRDHLLMLSEVFTFLIFAFKNHVEYGKPLIPKLTDFIKNYIENKEPMRLLISSEDILLEFLAVTCKLLRLLNDSAMLRQSPLIPEICVFLLSYTPNDTPELRKEIFYQIHLVALNQKELFKPYTEIIMNTNGFFTCRPVLAQGVNLAADLSLNFWEKMSIERVYFLFESIVDVFEQEMPNMDLFTEHVDGKNVEITCERVNSLRLIVDALEKTVECFNLKKMPVPEQCAFYRRTYPLIYGIFACSDNAFIIKKAIKIFESVTKYMANGSGNVLLSLSFLCEYEVNILKKIFYLCIRNVTKIADLKETALIFAFFDERTFREIVTANLRNVMVADPKAIEILQFYLNFAPVAEPLAKDLFDFYTDVVKETKDYVLKEVETEEAKKKDGFLKKIFYTLFKVVISLPENKMNTAVVCIRKTLPVLLNTSKKPQFFEILRDFFYVLSSNFNKSGEIFNVIYEVFPAIFKTLNFLIDLYPMVETYVETLLSIPTSLNVLLPHIRQLVHALNIGMRGSNRLKIFSLRFIDNCLENLRSEFIDEQVHDEMYEVVDNLFYLLQFEETRVLAARVLTKLKDKHRVYLDQQNYLTENILPNSKTLLRVVSSGQDEFIPADEVLLTAIKYVRCGCLMPSFGEFKISFVQFRDVKKIESAPNDVLYTSFKIIKAFLSSIKRPSQVAYDAIVGLLELRDVEFQEENEKFLFWFYENIVNKGTAAGRNGSKYEDDAAYARIGMTGAVAEGSEPLNQGEESSKYECCMTGMRDDVALREFFVNALVETTHMPLSIKIQKDYPFNLFLKKYMQLCYYCNEKKRKAGFVGLMHLLRHRDLNGIEKYQSKIIKALFTCVEKSKFVVKDEVQNSVLLVLRKSLQDIHRETETTLIHGLANVNGNIREISQAALEYLCELRGAPVADLLCSYKELIMKNTLGLQYKANINGILENLSYVFLFRPPIIDLDENFYAFMNFVTRIMSRADVYHSALKFLGAVCTVINHKEHLRHIISVFINAIDQETCQKALRQLLSYMPEAEEIYDNICHRSIGELTNTMDENKIHKLRLLVETHPHYLINLLNKQGEVNQLLKLETVDSLHILSHFSLPEDVLIRLVKVLLATPPDKKILKNLLQNNPSIFHVFFTNVDLAFDHCRMLFKFPAVETLLSKNVELPHTAKSLIFMNPTGDDLIKYNLRISDLFVKNRLQKELQYVIDKNVVLREGFDSWNEETLLEYFLRSVDEMDYNNPFEVFYYAFGSEGGGRDAEGQAVGQDNTGRASYNAFGSEGGGRDAEGQAVGQDNTGRAPFRKCNVNSLILGDYLSDRKFVANYKILENNIEIFRSTSNRFLKNQFVFHSYLAEYRNNDIIDYCRQNERDFACICYLSLYDSKKEYFNILSGTPTEYKRYVFKAFDSLTRKYDLKKEIYNLLSTEIFYKTHLFIIYPLVIRNEILNDEIVFELCDAVCRLFSTYVKVHQKVAIGLLLVVNNYIMLKKRDRDEIDGVRDEIRDGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTTARNNSTGDQIRDNMPRNTTARNNSTTMNTEKESTYNVILDAQISTLSSLYSLYFSNCAHTADPTFLKFQDYFTVPLRMSCLSINPETINISNFIVLLTKELKKQNLMAEVKEKLLGALNNISNLIFCDKFANDLKELVSFLESEWLLGVLRKLIDEFANHSVIFVLLEHLLIRRDEYVDQHDGAVSKTDGPADKENDSLVFDNLVVIAVNYCKAVCKLPNFNSMAVIKLLNSHGVLPNDVLAKNEKVGDDLDLLLLSYENRGVIDNNIFKGFKARKELREQFFGLVLKSGINLNLNGDAYAHLRVAMMKNNCELLLGDKNLTENILDLMFYDDQLLFYMRRNLLKVMDEEIEEMRMSYPQYRNYEIVNECDEKENAGNRSSDADTAGSSLEKSAGSSSEKTSAAESSAKNRFMRFLAPSNNDSDHYYAEMRLNAKYTETEEALKLMQFDDFIAAQKMLEKINKDLPFDEDEAQIWEREWVECAKELEQWDLVQEIGVMNNDIDLVTEALWKESNLSIEEERNGLLRLVKESDKNLSLLINAFLNNDDATYNRLLDRNIYKLMIYRDRHFLNNLQVTMEIRDDGIKKDRVPMYFEGCREWSYLMTLRNHANVLSGSLKSLHELAKNYNMMGRVCYENGHYDVAQHTITKIFSLSNIEVVDAYEKIETDLRIYKERNPSIGIEFVNIANLNYFTAAQKARLFNLKAQLIGDQKEASKLYLQSVQLADLSDNWYSWAIFLKETLDLTKKENVRQLFAAFLQSNSKHGIIVLLNYMKNYNFDILKQQLDSIDMREFLFYVSNLAEMLKSEDFYCAEALIERMLMVGAQTVYLELMRVNMSMAGGNEKENVAGRDGGAGGVFPTTGSYDALPTTRDGGAGSVFPAPGPYDALPATSPYDALPTTNSYDAHPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXANNTPVLLHSLLANNTAALLHSLLANNTVAPPLACLYERSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYW8</accession>
    <name>L7JYW8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0345"/>
    <dbReference type="HOGENOM" id="CLU_3144008_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYW8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5760" checksum="366B120390E1B626" modified="2013-03-06" version="1">MYRLSGRHPLLKMDNSHRITINKVKFSFVGYGISNKDVSMKYRLNNLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ01</accession>
    <name>L7JZ01_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0368"/>
    <dbReference type="HOGENOM" id="CLU_162190_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ01"/>
    <dbReference type="OMA" id="DLIIYCN"/>
    <dbReference type="OrthoDB" id="2187052at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031503">
        <property type="entry name" value="DUF5099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17025">
        <property type="entry name" value="DUF5099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="126" mass="14953" checksum="B1D79B78D5E58ECD" modified="2013-03-06" version="1">MLLKYYLSKIFGQKLTFAKKPNLIFIINAYQNISLDEIQRLRDKYGIEKIVGLQRDDFDTFYTQEQLDRNNLPDLIIYCNIKLEFKLRQPEILYKAEIVFSRFGFSEGLFVKALDHFSKCIINNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ12</accession>
    <name>L7JZ12_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0731"/>
    <dbReference type="HOGENOM" id="CLU_897674_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ12"/>
    <dbReference type="OMA" id="ANIWIVC"/>
    <dbReference type="OrthoDB" id="10392499at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="310" mass="35277" checksum="93F91984801C3ABA" modified="2013-03-06" version="1">MSNKKLAEFISRQASAKKIPIARELLNGASHLGPHVESFTFKAFSFQISKSYSEFMTFNRDCCREAWFNIYDSFLHLVKREFMTNESSHPLFLRLIPEGDLRGSCKSNLLTTPSSGIDVCQESLQPENKEVNDDSDRGGHETQHSQEDVGAVTRTISLHELIEKKGVINLFENCSTVNRIARIAAVSALYGNVRYNIEGVNADCIFIDNSLLISKFRTQTENVTQTNKLVIDDAELVIETEMKLDNKVFRLTSFVYYGVIDSPLLDFKLYVRESEDKWKCLCWLGLCDIDSIDHLLMNTANVLAMSYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ22</accession>
    <name>L7JZ22_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0294"/>
    <dbReference type="HOGENOM" id="CLU_574377_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ22"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="476" mass="54370" checksum="2D84B2BA0B228690" modified="2013-03-06" version="1" fragment="single">VSACLTGCARSLRVLKCMHGMHIIHKNLKCSNVFLSVRDGKDVVKLGDFGISEAKFKNRMPIVGTPEFLPREIYEGSRYTEGVDVYSLGFLLIELCTGTWPYAECKDEFDLLKKVLLGQLPSAVHKIRDPCLKHLIFRCITSTYDRITVDELLEHHVFFPSEECNHFCICERPGTVLQLARSKNSLQCTLISIQPDAMHLQLHLPESEQFIRFKFHNDKDTIDSVMSEMLEEEIIRTNMYAELCDLFKTGIERAKKIKSLNIVEEGIFDVGMIEIKQIQLGEQLIMDVEQGYAYAGRADEDGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXERVSMRAREEKALTRAKEERVSMRTREEKALTQAKKERVSIQEHPRRWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ37</accession>
    <name>L7JZ37_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TATA-box binding protein (TBP), component of TFIID and TFIIIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ37"/>
    <dbReference type="FunCoup" id="L7JZ37">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0429"/>
    <dbReference type="HOGENOM" id="CLU_060161_4_2_1"/>
    <dbReference type="InParanoid" id="L7JZ37"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000120">
        <property type="term" value="C:RNA polymerase I transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001188">
        <property type="term" value="P:RNA polymerase I preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="234" mass="26732" checksum="60D60315690FFBD3" modified="2013-03-06" version="1">MNAPLQFVDFSAGVFFKNYHPLKQKYKKQRDTPMDAPNLSYDFNADSAQEQNKKTRITPTLQNVVATVNLECRLELKVIALRARNAEYNPKRFAAVIMRIRDPKTTALIFASGKMVITGAKSEQASRIAAKKYARIIHKLGFNTQFSDFKIQNIVSSCDTKFNIRLEGLAYAHSNFCSYEPELFPGLIYRMVNPKIVLLIFVSGKIVLTGAKVRDEIYQAFENIYPVLTKYRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ91</accession>
    <name>L7JZ91_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993878">
        <property type="protein sequence ID" value="ELQ76077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ91"/>
    <dbReference type="STRING" id="72359.L7JZ91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0953"/>
    <dbReference type="HOGENOM" id="CLU_000384_33_3_1"/>
    <dbReference type="InParanoid" id="L7JZ91"/>
    <dbReference type="OrthoDB" id="2194935at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="124" mass="14894" checksum="C045CF53D886DE1D" modified="2013-03-06" version="1">MLMTPLFEKHKKDKFYSQEEEIKTLESVKKEIVNAKKLLIPDQTKLFILFTAASQTIIGGVLCQTKKDEMWANTWISRRFESGEINYSIREREYLAIVWCIKKLRIYLQNEFIIYTDHRSLEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ99</accession>
    <name>L7JZ99_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Armadillo-type fold, Armadillo-like helical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0684"/>
    <dbReference type="HOGENOM" id="CLU_378642_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ99"/>
    <dbReference type="OMA" id="EDMAYIC"/>
    <dbReference type="OrthoDB" id="2196165at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="732" mass="85376" checksum="8FD4B0AB1B3A9DA0" modified="2013-03-06" version="1">MRECLGQKAINEKNECVCEQCVNERVDAKLTVEIDTDRVNEKNTLVGDDIRYKEFNNSGQSDLAEKTPDEPKELKEWMEITTSPSLVYEELCIDAACSIVNKGVEEPTTQIEIIIEEFDASYNDDECKHFNNCYGNEREETCLELKNEYEYREYLNLLSENVDIVFDRRDCYFCANCAQQNNNYTQDVYEKGTRTIRNSQFIDNAEPFADRDFLHACSDQSQCLDKENNAQIVHINSDIMEQRPFHCTVQQNDCEQHFPRKIGSTKSVDSINMINSEEQKKHCHTPKYSKSRTDIQKLTATDFIICSLDNDVRVKSFHAQNDKITVIFWNVKNAIDFYKQYGTIYRLRFISVKRNFSFLFYNDQIWKDKQHTVDKKSNEKNISGSLSPLVEKRSLTSYSKKFKENFYESEEWPRVDYSKEFNERVCELEEWPRVDHSKKLNERVCESEKWPRADRKLNEKENPLMTSYVAGNEDKPHLTVLNTLKSKLRYDKDGVRGDADAVLVYRNRPIDYGAVDKQRSGANDFLLNYEHKDQLLYGLTVPSQHFEERVRHFSAQSICYTAADIKRFKHMSRIDQQAAFISECKKIAVGMHSNILAQEMIKNMRNDQITKVIRVLGEDMAYICSTKYGAYSIQALLNVKNLTKDNKRSIIASLKRNALNLFFHPIGNYTIQKTIDYDPMFLSDVIAQNSESILSNPLGTKVYKNCMARLDMNKAWNNMQESEVDDQMKTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZM0</accession>
    <name>L7JZM0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0109"/>
    <dbReference type="HOGENOM" id="CLU_621977_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZM0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978928" evidence="2">
        <location>
            <begin position="20"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="441" mass="48716" checksum="DC93884F31848585" modified="2013-03-06" version="1" fragment="single">VVCGMIAVLISLLLLKVNSGFFDGNVGFYELGEPQACLNEKELQRCNPEARTCGNTMSNIQTNNVELNNAGVYSQKLAINPYSGVYDRITAGCLNADRSELEAPRKTNGEHSTQNCVEHSINKSLSICDGQEETSKYFNQGNVNPCEQLSEHCKNTVQVSESKTINTAKTCLNDESDVLDQSCQSTNVSHGCNPNQVRECPESYERTERAEEHFYACSNGENISEASNTDILPCHDEVRKSDETCPGLHAEVSDLDHKNYSGFVDWIDLEWDEVISASLYGTNCESDSSITIENELSLVDIDAKNDVSALADRNIPINEPLNGTITKNISPDLQFNDKCIETPSLSCECNQQSENRNWKNIKNLSQINNSASSTETDNFSVSSEHSSTNYINNNKGTDNALNTEIRSAKTTKVNFDLKIFIILISFLIVCACILAFLIANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZN0</accession>
    <name>L7JZN0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription initiation factor TFIIIB, Bdp1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZN0"/>
    <dbReference type="STRING" id="72359.L7JZN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0831"/>
    <dbReference type="HOGENOM" id="CLU_134553_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZN0"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="1">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="102" mass="12350" checksum="191C0A85F1E8392A" modified="2013-03-06" version="1">MDNKLIHYLQNKNFRKKKEKAVSSPPKRQTTRWSQKETQLFYKALELCGLDFTLISKLFTRKSRKQVKKKYMKEESLNRRKIEEIVKNADFDEDKYNALTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZQ3</accession>
    <name>L7JZQ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0116"/>
    <dbReference type="HOGENOM" id="CLU_1713232_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZQ3"/>
    <dbReference type="OMA" id="YFINSDY"/>
    <dbReference type="OrthoDB" id="2193909at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031527">
        <property type="entry name" value="DUF5091"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17012">
        <property type="entry name" value="DUF5091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="170" mass="19928" checksum="127E29C7A2C715E0" modified="2013-03-06" version="1">MFLKFLNKTPPMQDYLKQLNHVFSSPTFPNILAVFEKDSFIRFNMIYISPITLPHLKAKLENLGMLSWEITSSGINFFFVDFQLQFRGHLTVHRMQRVFALELDFEPVISRTERSGILNELESYLKGCDSVFFMSYFINSDYEILSNSLANSISYLGRRVVEKRKEGEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZQ7</accession>
    <name>L7JZQ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZQ7"/>
    <dbReference type="FunCoup" id="L7JZQ7">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0229"/>
    <dbReference type="HOGENOM" id="CLU_1220435_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZQ7"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="4">
        <location>
            <begin position="81"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="227" mass="26831" checksum="43C539093165D041" modified="2013-03-06" version="1">MNIFMNIVMNIVINIVMNIVINIFTNIVINIVMNIFMNIFIISTHTFHFLWTLQNAQFAKVKIFKNFCMPFSMVETLTKFKIYPQQPQIYNNPKNEEKKRYYRQVGYGITVPETAINGTYIDKNCPFTGSVRLYGKFIKAEVLKMKQVRTIICIKKYFFYVKKYKRYERRQKKFAVHFPPCFEGLVNVGDIVNCALVRPLSKTKRFVVVGVENKIVPEKKYKTLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K013</accession>
    <name>L7K013_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K013"/>
    <dbReference type="STRING" id="72359.L7K013"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0365"/>
    <dbReference type="HOGENOM" id="CLU_775149_0_0_1"/>
    <dbReference type="InParanoid" id="L7K013"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="358" mass="43102" checksum="FFB7009D26936D73" modified="2013-03-06" version="1" fragment="single">VMELLYDWALRTLNLEQFNFKKFFRDQFIKNATNSVIQRIILDKRNHKFILNIGKFIILRIFDNKGVREAFLKTYNSSNAEHTIQVVEEMFNTSHKSGEKILKDLIIEKRSPILYNLFYDKCVVIDSAYIECLLICKNHLNLLRFEMLEKLLDSYYLNFLIRDKTIFQKLTLRVSDYVLFLRQKRRNFDSEKFFINLVEKMVLNREEEVKDQILQRFNEINYATISISNLTLNLRRRNVEKHKNYLNNISFEIFERSLFFLNTFPEILRHILPFLHELLVTFNKEYKFYRDFKGEERGDPPNSTFADDDLTDINACGSHLSLRTESIVCFSQIFNNKIHNDLPNTQPNTRLYRRMELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K073</accession>
    <name>L7K073_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K073"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0514"/>
    <dbReference type="HOGENOM" id="CLU_2967564_0_0_1"/>
    <dbReference type="InParanoid" id="L7K073"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6650" checksum="B18D804D3D269AD5" modified="2013-03-06" version="1" fragment="single">VIHVARKTCIVCSHYLRKDDKGNILTILCRLFHSLPLQSNCVLPLCPISYRASSNSCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0F6</accession>
    <name>L7K0F6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0F6"/>
    <dbReference type="FunCoup" id="L7K0F6">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0F6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0023"/>
    <dbReference type="HOGENOM" id="CLU_058320_0_1_1"/>
    <dbReference type="InParanoid" id="L7K0F6"/>
    <dbReference type="OMA" id="VRDRGYF"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="23131" checksum="ACF3C55D48C9A335" modified="2013-03-06" version="1">MTSVRNQYLVRKTVLEMLSDRGYSVKEYQVNDYDDFVNKYPNCVKDTTNLRIIVQKDKEMLFVFFSDEEKMSLKSVKILVENMEKQNIKNLILVLREGISPAANKFALECPMNITIFKEKELLFNVTKHSLVFKHRIISVEEKERLMDEKKIKEEQMPRILITDPVAKYLGARKGDVLEIERESETAGSALYWRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0F9</accession>
    <name>L7K0F9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0F9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0381"/>
    <dbReference type="HOGENOM" id="CLU_115067_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0F9"/>
    <dbReference type="OMA" id="HTTEFRE"/>
    <dbReference type="OrthoDB" id="10662023at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22977" checksum="E60081B88E22ED33" modified="2013-03-06" version="1">MAQIIGCLQKNKLSLIFLTISPTMLIVVALLYIALRGMSTRKLSTHCSYDGDIFPEEKIFVNDGTKFGFRQFPGDDDEEKVEVHTTEFRESRETNEFIERDVESSIHIDASEEDNLKMQQGVDEVKEGNEVIGLNDPLVSNQGNQNDCVVLTSDGDSCASYQGVDKVEEGDEVDEPVISLGCGQESHNDSIVLEENECGTLSLQMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0K5</accession>
    <name>L7K0K5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0K5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0088"/>
    <dbReference type="HOGENOM" id="CLU_2198832_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0K5"/>
    <dbReference type="OrthoDB" id="3366231at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="12577" checksum="AAC6C174F364F182" modified="2013-03-06" version="1">MSIKCSRLWKHVRVLKLSQNMRAANQEEFSKWLLDIGNGLSNERSLVEIPQQYIANKDIANEIYEDLINSLNSANLTNKTILSYRRHLQINLKLITFFAPRSTNKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0L6</accession>
    <name>L7K0L6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molecular chaperone (DnaJ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0L6"/>
    <dbReference type="STRING" id="72359.L7K0L6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0045"/>
    <dbReference type="HOGENOM" id="CLU_477359_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0L6"/>
    <dbReference type="OMA" id="NEQVKQM"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="354"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="479" mass="55699" checksum="A65D9D999C16F8AF" modified="2013-03-06" version="1">MILFLLLVSTESNLRQNLDLFFSYVDNGQLRTARQVISNLFDNDSSNALVRKKYASFLMELGDYDKVLAVFKDDEKLVGEAVKMKTMLKNLKENVHKIYLKSPFSKPVMVELIKQKMLTNMSECYTLLSKAEMLFKDDDKIIYLRALYHAFRSENQLAHQSLLRSGSNRAGIFKNMCDMYKKLSSGSFRYAETKGLVDKLRTLQVNDKHPSIFYMLLINSLVFLVKNGAEENRKVTEYAELLCKLEKKDDSYVLLIKALLAEGKVKESCEQIGKIKNASLRERTERTIEVMKKKKIEERKRAEEQRKSENKRKTNEEERKRRVEEQRRQEKERKEKQRASQHQRYAGTNTDSKGYYKLLGVEPTATPKDIKARYNKLVLKYDVDRQKVKPTEQEKERLTQKLAMINQARDVLLNPKKRKLYDSGMLDQQGYGGGHAAANNEQVKQMLEAFFGRGGGQSFFFDLGGNQGGYRRSQTFYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR89</accession>
    <name>L7JR89_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3081"/>
    <dbReference type="HOGENOM" id="CLU_3279810_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR89"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4813" checksum="45A9787AD9C6FC2B" modified="2013-03-06" version="1">MVKNELERYKLCKTELKIFRMPDGKKTIMSLKLTNEIGNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRF7</accession>
    <name>L7JRF7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="13">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">THOM_3240</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="13"/>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRF7"/>
    <dbReference type="STRING" id="72359.L7JRF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3240"/>
    <dbReference type="HOGENOM" id="CLU_006515_4_1_1"/>
    <dbReference type="InParanoid" id="L7JRF7"/>
    <dbReference type="OMA" id="NCATIVA"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="10"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="742"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="761"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ELQ73865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="867" mass="97273" checksum="3497B8824F28F885" modified="2013-03-06" version="1" fragment="single">VPSMHKMKINSINITFPFKPYPAQILTCSKIIDCLKNKKTGIIESPTGTGKSIAILCAVLAWHATNRSTRIFICSRTHKQLDQLVAQLRATAYAPKVCVLASRRALCLNKQALKGDVNASCRDLVKKGECRYFMGKERLAKSIGDVHDIEELRQAGERCTGCPYYASRMLSEDAAITFMPYNYVVDPMVRRTMGIELKDSVVIVDEAHNIEDACRSAGSIELTNDTIDIMLKELVGVYRRVEEYREDLVVLNYFLRKMRGLSDVKMTRSSADSECACFKGDEIVQHLAHKEVVPELIARMRMNALFKKNEDLKDAFSLVFLQTMESLVSVLMLVFSGKARSYALIVKGAPSAPSLNFMLLDADVMFNAVVQHVHALVVLSGTLTPFSAVENELNHHFTYSLVAPAVAQHTFCATILRNARTGGDMLGTYAYAECLEYVDEVIDVIYGVSGCVQGGGTVVFLPSYHAVNKVVSRMRSRGTNAGGSTVGGVMGLSGVMGGRTEGRNTMSNINDKNINNVNNINNRNLNNLNNINDKNINNVNTRNLNNLNNRNSNNINDKRTNSIFSNKIQKNIKIQGNTLRTAFQNRSEIKNGNNCIDNVFIETNDKNFSKVFAQYKKHPNPILLAVYRGKASEGTDFKDKLARAVILVGMPCPNIKEIGVELMRNHRPGWYENQIFKAVNQAIGRCVRHRMDWGGVFLVDVRYRRDKDRLCGWCRDRMVYGEYFGDVVDDFREFVGRMKEMDRNRSSMEGGRKSLMSGGENGKEGCNENGKEDCRESGKEGCNENGKEGCRENGRGNNLENSKKNNLENNPVNNKENDGNNTIITKNAAIKEQTYLKNDNFIEREYKNRKNTCDEEGTVKKTRIDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-03-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRL3</accession>
    <name>L7JRL3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3126"/>
    <dbReference type="HOGENOM" id="CLU_847849_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRL3"/>
    <dbReference type="OMA" id="LWIDEIT"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978773" evidence="1">
        <location>
            <begin position="27"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="337" mass="39124" checksum="F274556ABEEE3BE5" modified="2013-03-06" version="1">MRNTNNNTMSNILYIFISELFSLIQTQLITNQSNVWVPTSNDSLEEAYHVDTELSSQLQELPGPQVIVLLTNELLNEYLADHEVNYTLESLGITLYSVVETRKEIHTVFKTQLDTINSKFEFLYTNLPIYHFNESETMAALRLGCFFHVLSEKVGNVDFKKSHNWFVRHFLDFLCMLINKMQPICLTFKNMSNFQSLDVFETNVKILIQACRISLDLVEEHYDFNHQSGLNLVMLVGITNSLETISGYIINEYLRFDNIITCLNIMEMVNKFKQALILLLNLVLTSVQTEFWLLILDEPCECGFYDEKCRSFAKNDGPIYCTMCLGMFITETYSLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRT3</accession>
    <name>L7JRT3_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase (Reverse transcriptase), Non LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">THOM_3076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994088">
        <property type="protein sequence ID" value="ELQ74010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRT3"/>
    <dbReference type="STRING" id="72359.L7JRT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3076"/>
    <dbReference type="HOGENOM" id="CLU_2428623_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRT3"/>
    <dbReference type="OrthoDB" id="10014409at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="91" mass="10409" checksum="6DB9D730A3B85034" modified="2013-03-06" version="1">MYRRPHTSLRTGNTRSASFMYDIGVRQGCPASPILFNLYINDLFDGLSRIAMQPGMQSIPSLLFVDDAVILAEPAYELKRSLKKINDWCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRX3</accession>
    <name>L7JRX3_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2859"/>
    <dbReference type="HOGENOM" id="CLU_3052060_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRX3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6008" checksum="D05A430B009DB7C3" modified="2013-03-06" version="1">MSACRPQGLPTRPVICKEVIGCKICSRRWKEGLIPGSKYEALCEVVNVYNPGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS27</accession>
    <name>L7JS27_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2812"/>
    <dbReference type="HOGENOM" id="CLU_2591477_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS27"/>
    <dbReference type="OrthoDB" id="10301728at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="80" mass="9252" checksum="C77B07A11B090269" modified="2013-03-06" version="1">MLKKNNRIARITDQDDFELLDNDRLGNVLDDNEIIVCYNCSETEDSEEKDMNENNEPEKRRVQVSSVNKTSESESAKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS51</accession>
    <name>L7JS51_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ricin B lectin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2851"/>
    <dbReference type="HOGENOM" id="CLU_125088_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS51"/>
    <dbReference type="OrthoDB" id="2199193at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978668" evidence="1">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="153" mass="18135" checksum="EE69D974B618EB6A" modified="2013-03-06" version="1">MLIRILILLNVPFVVSKLFKIKHLTSDLYIGKSGRYPKWLTLARANSFIEKPSKEKGKVIMKVTDLRNKVWNIEKNKKRLIYFPEHGRSNQIFEIQRSKHGWIKITNNDKCLTYIKNKKRFELRKCDDGKMTQVFLMADEEGKVMSDEDIDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSA3</accession>
    <name>L7JSA3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2929"/>
    <dbReference type="HOGENOM" id="CLU_370136_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSA3"/>
    <dbReference type="OMA" id="RCKFYFK"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="752" mass="87315" checksum="5A4EBEA30767C289" modified="2013-03-06" version="1">MSAYYNHLNKHQSTSVGQEANTKSVDSREKVAIKGKRGRKRKVLTVQLQGSKPAAKRGRKKKNAKEEPYAEYEEKKRYAGDDGRYATSIEKRYERDDYATRCAEEYREGHCSEYRCEDDATSDYTRGSQECAGGRDYVRGCSIADSMIRSDSINYERVDNNRLSYSNERTMGDMAYSSYEKEEWLDGGMRNACLEREEMQRSYGEYEAGERIRRGNSNICVERYAENESASTAEGPYTHPGRCSINENVLHNEQLYAHQEQYLRNKRAFDAGGLRQQHEVYSERGSVPNAERPYRYLDRHPVDEKICNVAFEGNAQNQCHERYSMNDRVSTTGGPNQYYERCPTWNMRNRDYYSQNDGLLYHHVGNDSRFYHSVSPSFNGDVSCNTEYQINEQSHNTNRILNVHERFYRDNSCEMESRPSEDYTASHYHEDADSLCTNDFQSFSERYGTNTWSRKKMLHRRGRPRRPSPGNTRATSRSTARTAKSIAHAYNYLKDEMPKFSATNELYKPREGMDSNTLKDEQGCDSSDVCGQACENKADVSDYNGQYANETVNETEFYTSERCDSTYAKDYVSFNDAYASTSSVPEYHSARNDTYNNPLCPVNQEAAVRYGAFQCVRCKFYFKRLSTLKIHMISHLKRADFFGCTRCDSAYKTYSLLKKHGLKEHKERIFDVNHSELRIFVAFLSIFSDFYNPFVDSFCFNCFTYPKSLKLHPCKGKYFSEKKCMLCGDKMKDIKEHILNGACKSKVKYEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSA5</accession>
    <name>L7JSA5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2726"/>
    <dbReference type="HOGENOM" id="CLU_2851320_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSA5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7720" checksum="5C853661BE19C9F2" modified="2013-03-06" version="1">MLYESDTMNQRSSRPRSALSTPGEFVWCVRKCEVLIRRTFKQKKIFVRSIEVVILVSRPKITLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSF7</accession>
    <name>L7JSF7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2727"/>
    <dbReference type="HOGENOM" id="CLU_3093284_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSF7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="52" mass="5428" checksum="FBACE46D8666DD25" modified="2013-03-06" version="1" fragment="single">VKNSNLFFDGFWGGVPSTPSVEPTPAEVAAAAAGSRAASYRFSRRMSTSYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSK3</accession>
    <name>L7JSK3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase containing von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2642"/>
    <dbReference type="HOGENOM" id="CLU_314780_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSK3"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="929" mass="108089" checksum="081B25D20753C0E8" modified="2013-03-06" version="1">MALFNELTSIDPLLLLIKECDVLPDIRRLLIRTYKYGKTDGINTINEFIREGLSKMLTRQQLCSQMAGRDFERFKRTIRAIEHCIQQHNDLNTFLRSMLNEHTLDMYVYYRLRIVKLLRCNDKQRLERYKRALIRCYLARDDDLNAYLRVVRGVDTFTDGYCAFFYRTFFRRTGGTVWLFVVEMVRGGYFVCDEMLNEGINDMFCYRGGCRDEYCSKDCSRGKDEDCSRDEYCSKDCYRDKDCYRDKISSKVKISSRDENDNTITTTTISTNTIIDKPRDVNYKVLLHILTREWHIKTLEPFLLLYSYQHFRSVLFFLKELSLSKHVLPNKSLFYGVSLQYYGYDRDIKEEINALEVIKEVEMRYDVRCYRCCDVMEKVYGMLWGKDDGMLVGKDDGIECWCMRVFRMGRVDGMKDVVRVLEESIKSGDKVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALNFDAEMDGQLIERVNTILYARRAYKGDYRTGKKLNMKKIVQFIASDYQKDKIWYRKDGHTPTKIRIFIDNSRSMMHYNLQKLCFVYRRLYGAFKTLNVPTELYKFGEHCTLIHSPNDLMFNDSVTNYSFVESFCDGVNIVLTDGISNELQGACNERFLFLIFNREILRMESVRYVGDRMVRSRYLDGFRFRYEVIGDVEEIEESILVAMEEMVIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSK4</accession>
    <name>L7JSK4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSK4"/>
    <dbReference type="STRING" id="72359.L7JSK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2809"/>
    <dbReference type="HOGENOM" id="CLU_768491_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSK4"/>
    <dbReference type="OrthoDB" id="10583697at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="361" mass="41609" checksum="DF76FCFC29F838A6" modified="2013-03-06" version="1" fragment="single">VSNTTRTESLATKHYVINKVNDCLLMDSNERKRWEVDGCRGGDYEGGNDQGDNEKDYEEDNDQGDNEEDKEQKVKEEDKEQKDYEGNNEEDKGCVNKKCFNGTLPGEKKHRILIGDNLFYLVDDVLPEEWGVKEEEEREEESRKEEESRTRTVKVMEGLDKCEEKENVQKSMMSKNGLKDEMGIEEGKNEGVVKEEEGKEENDKEEESNKIRGKKNVKSNKRRSTPRSSTSKEKEQQAVGQINDRSKIKNAQKGVSKRMKCIKLVKRVRPSPNTSYTLFATENTENGDEEATRENFINTVLTNEIAQGSKNVCYRRIKTKGGARENDQPYTIVKINSFVHTEDGRADQVIFTVKDYKLDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSK6</accession>
    <name>L7JSK6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase II subunit 9</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSK6"/>
    <dbReference type="FunCoup" id="L7JSK6">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2814"/>
    <dbReference type="HOGENOM" id="CLU_093932_0_1_1"/>
    <dbReference type="InParanoid" id="L7JSK6"/>
    <dbReference type="OMA" id="EVADNSC"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase II subunit RPB9-like zinc ribbon" evidence="2">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="112" mass="13236" checksum="95A38B231FBF0F1C" modified="2013-03-06" version="1">MNKEFCPECSNMLYPKEDKIEKQLYMACRNCEHVEEAMNNKVVENVFHREFTEEIDQETAKDMTMDPTLFIANVKCGRCGHGYAVYFEPKGNNPDLELKICYICKKCYNIWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JST7</accession>
    <name>L7JST7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JST7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3002"/>
    <dbReference type="HOGENOM" id="CLU_3419470_0_0_1"/>
    <dbReference type="InParanoid" id="L7JST7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="25" mass="2813" checksum="C4660926602F7B3E" modified="2013-03-06" version="1">MVEGERVVGSVCFGVYRKDDILRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSV1</accession>
    <name>L7JSV1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA-dependent ATPase MCM, Nucleic acid-binding, OB-fold, ATPase, AAA+ type, core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_3257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSV1"/>
    <dbReference type="STRING" id="72359.L7JSV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3257"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="L7JSV1"/>
    <dbReference type="OMA" id="ACATREN"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF48">
        <property type="entry name" value="DNA HELICASE MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="4">
        <location>
            <begin position="228"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ73817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="413" mass="46441" checksum="80F18DEFA0D857FA" modified="2013-03-06" version="1">MMDVPSDFYSYAEINMLQLCHKHPIFAHNFVQNNHLFYEAMVDKKIKNVPPSLLLKRFPRCDKINHLVLLRGTIIKVNPILLKDVEQSYRCLYCDHSEIVKSANYKKKKKIVCERCGKDNFRIDEVFTKAKNCQAIRIQDIGNPQTMSDTIEILITGEQAGKFLPGENIEVLGIVRLKWPLLKINEKLSPVIYLQSHSIRRTEKTEPLKFEGLDDFVGVEHFDKQRFLIKTFMNEIVGCENVKLGILLSVIGKRGKDKETRNNSHVLLVGTPGTGKSHFLKSVAHLAHSVSINGVGTSEAGLTTCAVKQGKEWLLEAGALILADNGLCCIDSFDALPLYDKRGLLEVMEQQTLSVAKAGLVSTLNARCSVIAAYNISYYDTTKSICDNLKITSPLISRFDLIFFLMKSTGMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSW9</accession>
    <name>L7JSW9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSW9"/>
    <dbReference type="STRING" id="72359.L7JSW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3212"/>
    <dbReference type="HOGENOM" id="CLU_442264_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSW9"/>
    <dbReference type="OMA" id="NDYERTN"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011936">
        <property type="entry name" value="Myxo_disulph_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02232">
        <property type="entry name" value="myxo_disulf_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978699" evidence="5">
        <location>
            <begin position="28"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ73837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="618" mass="71691" checksum="BE31D8D5FE2C3BBD" modified="2013-03-06" version="1">MKTKQIMLFIALTICAVIERTLPYVHSSDGTLRITDERILYVTFYFGARPFIVVLTDHPYSTDMKIKRNRFLYSARLVDDRHSYGYMVVGTHLYGMVVSNEVKYEIVYEDGRYKVEEKKMLYSRNDNNSVYDSKEYDSKEYDSKEYDSKEYDSKEYDSREYGNSVYDNIEYNSGKEYNNDKEYNNDKEYDNTMKYDNTGIIKGTMSIEDGKECDDMNTTEEENSINNDNTTRITEEWRKTSKEKAKEAPTHNYHAQTTNKDTLTYNRFRNNVKYFKIVFVNDYERTNTIQNIEMVARRTFLDTKEYFERLGLGIELVLIDVLNIVEPVDFVERGKCALLSGDGMVDKGLKNENNDELRIKKDEELEMEEEGTTRNENNDELRMEKDEELEIEEEGTTKNEKKKTSKINNNQNDGLKKMNRKKNGTKEGKQRSHRTICGTTSQNGHINVSEPYECTSSDVHAYSFLSNFADKFDSLKNDVRNEKLNNVNLFVLFSSDSISTTVDALTFRSGACSLANNYSVVFNTAFARMNTPKVLSHEILHSLSADHGDKLMAEETDGRWEGVSDKTRAEILQFVNKHGKCFDDGQRCGNGIVDEGEECDDGLMYGSERCTRECRIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT19</accession>
    <name>L7JT19_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.231</ecNumber>
            <ecNumber evidence="9">2.4.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.231" evidence="9"/>
    <dbReference type="EC" id="2.4.1.57" evidence="9"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT19"/>
    <dbReference type="STRING" id="72359.L7JT19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2538"/>
    <dbReference type="HOGENOM" id="CLU_011001_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT19"/>
    <dbReference type="OMA" id="GKWIWRC"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033832">
        <property type="term" value="F:alpha,alpha-trehalose phosphorylase (configuration-retaining) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="100"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="311"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="542" mass="62739" checksum="2038C57A2A21CE50" modified="2013-03-06" version="1">MNNRIFWSMLDAFPCYFFSSLKDPDSRADSFARKSTELIGYNGIIQLEMEKHNKINVNLLGSSLVSIEDYKSFYGPFYSSIFDEIALLARDLKTKRISFISSTSRGGDITLMRQAQMRFYQLIGANVSWYVTIPVNTVSKIVKYKLRDVMESAVPEDTILQAQEIIDLENWTSMNVSRLWHNSVFKNTHIVIFDDLQTSGFVRYLREINPEAKIIFRSHIHMNAEMYLRNKAVTDVYNYITHNLEGIDLFVAQPMNTPIPQLGMHPIVYLSSSTDPLDGLNKTLSDTDRAYYTRIFRESCHEHTRKYFRFQSPYIIQTSSFDRLKGQKECIDAFRIIYDMISTRINDESDALYGLYLLIVGHGNIDDPEGTAVFNELVEYLNEQHNCAVRDRVLIVKIPPIEQILNVLIENARVALQLSQCDGFETRVTNCILKNVPAVVNNVGGLRLQVLENKTGYIVDRGDLQGVAHKVLYLLDNDSFRNGMIEYREYSFMFTTPFNVYGWLYICKVLVEGGVITEEDVFKQIIKKYFHKYAHEFLLKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT35</accession>
    <name>L7JT35_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT35"/>
    <dbReference type="STRING" id="72359.L7JT35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3195"/>
    <dbReference type="HOGENOM" id="CLU_025464_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT35"/>
    <dbReference type="OMA" id="SKYVCSF"/>
    <dbReference type="OrthoDB" id="2189058at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="513" mass="60896" checksum="5D11429C4C6CF9D9" modified="2013-03-06" version="1" fragment="single">VKKEMGRKWKRSRNDELMINTADRCEELPENVNKDNRKEENGALRGITHVESVNDTSTDITKDDEDIKDLLSRIKKGVEERESARPIKLNKFGIDKPSVDEKLMTDTELTVLDRRMKAYYRQLNEIDKAKYQRLGDHFIRGSQIRSLLKDSNIVLKIGPFNAEEQKILKHKVNEYLRNRNLTIEYLQERILKGDDTAFMNDISKYVCSFMPFRVYHVVHLGIFYYYHPYANKVFTLQDDLELMQLYKIIGPHWEKISKEMLSTRFRVHRKFLAMQNLKRLKSCEGDFYNEYLKTRNIEKVAKMYNTKYGYVRKKITEEIARVYMNKWDDYCDFVVAVLVLKYNHYCGINRVGKIFKVLDRIVEEYTLEETVKTSDELEKEANAKGFGEQNENSNDGGQKHTKKKQKDNYKSAKLCYEKIILKNETIKAKIERFFTLNMDFNVEIHENDIFWLSVRDEFNDKHSENIVNIEPAIIRSKFCILCKKSNIVYYKNLLDYTKTKALSLIHEKLIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT68</accession>
    <name>L7JT68_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2872"/>
    <dbReference type="HOGENOM" id="CLU_1225521_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT68"/>
    <dbReference type="OMA" id="NEIRRMY"/>
    <dbReference type="OrthoDB" id="10582394at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="226" mass="25761" checksum="04691119EE90D7C7" modified="2013-03-06" version="1">MMDTELLSSILSAYKKLRLEFHKLRNEIRRMYSNTKKSIKQEIREVRMNIRGTTRKSRRVKGEKRCMRGRNNGKIDNRVRRKSVVMKNANVEERMKGRSVGEKERIVGNGMKGKGAGEKERILGNGMKGKGAGEKERMVPGVNIVEEIHKMDDKNAGGARATGNSVNEGLERKKQVYEDMTGNNALKSRSRRGNKSNTNIEKEKNTTNENTNSLGPFMKMLQEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTD4</accession>
    <name>L7JTD4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTD4"/>
    <dbReference type="STRING" id="72359.L7JTD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2359"/>
    <dbReference type="HOGENOM" id="CLU_630383_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTD4"/>
    <dbReference type="OMA" id="CAEPVDI"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="402" mass="45537" checksum="3008CD5C3A7BD8AF" modified="2013-03-06" version="1">MISIKSIKPLKQQFSTRDEIPFEITIDTDLDNQDVEFSIIYCGDPEKDAHDQKLSEDIVGPLSKGRFGFTLCAEPVDIMKVPAEMVFGVTSIVIIGRFKGRQFVRAGFFVNVSYPGLPNRILECLDVRDDVDVSLVSSCEDNEQFGKYEDDEEREINSDEIKYESSDIESVGEEDEDIDDEDVEDDEDVEDAEDEEIEDGEDAEDVGDIEDEEIEDVEDEDKEDAEDVEDENVEDIEDEGKEVEENVLKEDKNKKQLKGDTEKLRKNAEDRTGASKQGINVVVNESDKDEINGSEEQDEGSESKSKRRTKRNEDVEKSGEESCVEQPDELNPAHDEDISLFLANPDFTEGKGIPEENQVKLKGFILDKDKIVFELSEPPLITVFSIDDEEGEENDTIKRMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTE7</accession>
    <name>L7JTE7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTE7"/>
    <dbReference type="STRING" id="72359.L7JTE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2392"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="InParanoid" id="L7JTE7"/>
    <dbReference type="OMA" id="ISFINGY"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006527763" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="207" mass="23546" checksum="3A2BCD9332DD35B4" modified="2013-03-06" version="1">MIAVSTLLFFSIVSLRQVFMDVAYYDPVKSQEITKRIIIELFDKDVPKTCDNFYSFIKGCRVNGQNLSYKNSIFHRIIDGFMIQGGDILNGNGTGSISSYGKPFEDENFKYKHHQPGMLSMANSGPDTNGSQFFITTAVTKWLDDKHVVFGQIINNTLQNVLDISKVPTDERHRPIKSVVIKDCGDFCGRGKEEGVIVRKYFFAIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTI6</accession>
    <name>L7JTI6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein P2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTI6"/>
    <dbReference type="FunCoup" id="L7JTI6">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2350"/>
    <dbReference type="HOGENOM" id="CLU_2308025_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTI6"/>
    <dbReference type="OMA" id="YVAAYVM"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="100" mass="10985" checksum="8F42FC0CAFCCFC44" modified="2013-03-06" version="1">MRAILASLILNEAGLEITKQSISELIRKAGAEPQDDEVENFLTKLDGKNIQEAIAEGLGMMQSVESRANPAAKEEEVEVEEKSKEPPKPADTDVDLFDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTK4</accession>
    <name>L7JTK4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA helicase nonsense mRNA reducing factor (PNORF1)</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTK4"/>
    <dbReference type="STRING" id="72359.L7JTK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2678"/>
    <dbReference type="HOGENOM" id="CLU_001666_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTK4"/>
    <dbReference type="OMA" id="AIFINCD"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF317">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE ECM32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="100"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="339" mass="38756" checksum="67992D37436B6044" modified="2013-03-06" version="1">MQRMNLKNKKNTHKDRLRDYLRYSFVKDARVITCTCVTAGQELFKRFKFPYVLIDEAVQATEPLTLVPLIYSCRKLILVGDHKQLGPTILNKRAANAGLHVSLFERLIRLGVVPYLLTVQYRMHPVLCEWVSNTFYDGALVSAQYTHGAHVRYSAGTTAWFNLPMPTFFYVSRGKEELFVSGTSYLNKAEAQQCLAIIRHLKMNGVRETDVGIITPYEGQRVLLSRLTACEVANVDAFQGREKAFIIISLVRSNNINDIGFVSDRRRMCVALTRAKHGLFIVGNPGTFCKNKMWKELIAYYQGKGVLVEGEVEELRRCEVLGVTHFDFGNFVREVYHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTL8</accession>
    <name>L7JTL8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2998"/>
    <dbReference type="HOGENOM" id="CLU_1687966_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTL8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="172" mass="20297" checksum="3C38582F1C951BB9" modified="2013-03-06" version="1">MWENRPVSILEINNAEMNDRKNLRITDYFNNLKEKLKALQETYSKHFRNESKVLIKENTSFIKQEFDKIPYDDGTECMPQLNDILEELNRSANDSKLVNVMALSRLLKTYLICTNKPSSEVLKKINIKEIREFYAECKKYTTHNTFCGCRNACSELIDNLLVKLLEMLFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTM9</accession>
    <name>L7JTM9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2227"/>
    <dbReference type="HOGENOM" id="CLU_756906_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTM9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="366" mass="41901" checksum="164FB5EB6B7C3529" modified="2013-03-06" version="1">MFRPDSELHNTLSLTLDDNITSLIRDSDIDSHEMSDTVFNVLDGDMVIKQAKARNTGEIGLRFGYATFIIISVVLFVTVVILGMKIYDNSQKRNTESSLSQKRTRNEQELKKIEVQQQKLSGKISMLKKKINATEDPARQVRPKEGSILRDDENSDEQKHVIINTSSYVEKKDKQVQTEGAKPHEVIVGVACNQDRVEEVDFTFKSEDNGHRSTIVVIIEREDDVSKESKENSKAINDDNNDKSNDKTQIKLKLRTDEHDMKISEEKNVEKDCYADLLKDSLPCEDKSSDLPPTKRQETALKKHIERRKPDGTFKFYMKLYPNDIELEEKQNTNNMNGIGESSEPKSRSHSGHVTHNRNKFGSLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTS3</accession>
    <name>L7JTS3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin complex component, TCP-1 theta subunit (CCT8)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTS3"/>
    <dbReference type="STRING" id="72359.L7JTS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2635"/>
    <dbReference type="HOGENOM" id="CLU_1723614_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTS3"/>
    <dbReference type="OMA" id="MDFTRTQ"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="152" mass="17329" checksum="F082CDA5424B22EA" modified="2013-03-06" version="1">MDFSNTGLQSILNNSVQHKNVKLIMTVSKAEELIDIIASTFRADPYRKIVVDSYNNLLITSETTKILSSIKLVHPIQFLFKDVLLKMSKLGDGNTFLILFVGKLLRECRDLLVKGMKAPMIVSSLKKIKKELFVIMDDLKEKQKLILVMRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTT7</accession>
    <name>L7JTT7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2144"/>
    <dbReference type="HOGENOM" id="CLU_3160280_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTT7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5903" checksum="8CC59F6D1BDB300A" modified="2013-03-06" version="1">MENYKVNDVFDEKECYNKVFGKRKKISYLRWRVLVLILVRNGLLKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU10</accession>
    <name>L7JU10_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molecular chaperone (HSP90 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU10"/>
    <dbReference type="STRING" id="72359.L7JU10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2155"/>
    <dbReference type="HOGENOM" id="CLU_360990_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU10"/>
    <dbReference type="OMA" id="DEMMPNI"/>
    <dbReference type="OrthoDB" id="2196062at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="757" mass="85872" checksum="460FF19F52B10211" modified="2013-03-06" version="1" fragment="single">VRVALPMLLYLISAVCKMTTHEIAIDDEMMPNITRKLIHDPNAFLRELVSNSMDANKKLVMAAKQSDIDTNKDIILTLKDNVFTISDNGIGMNKDELVSYIGTMGGSGTRALGDSKNFVGKFGVGFYSVFVVADEVRVITKKYGENETYELVLKNGQKTYTIDTIDDRGECGTTVQLKLSEAFATGLDEDELKKWMKQNLLEDPLRNYTIRMCTDRKKADTKKEKSDDDEKDADKEPEKDAEEHKKVELFPWITSLDEKKLEDYYKSIDGPGKILTSNKMRVTVAQKDMDGKYQDVSFELLVVIPEFLDLRVLGMETKGKHYLFVNNQRVDLEPIPAFLGPITFILKSSEAFLVSTREKLLNSKDTCTALYNSIQKKVLQLIRAEMKKDLKKVMKVYDFYIKTGYVESKKDNKSSLAELFAAVLPFNTSDGLIMLQDFVDKLGADEDILYASIGHDTLDLPEGVYNPLFDGIKSPFILVSGLLEEQVVSMFEYKGKKMVNIVNKEFKNKEPANDDGFIAFCKRELKGVVDDVVMSVRLVNAPFFLKAKNAQFSQAHKHVIGEYTIKNSAFKKTIETDIVLEVNTDSDEVKSIKELISNDYDRAVAALRAGVMAAGVICNMVYNNTTVAFLNLINVQRNLLGMENVPIVVKEDDFDMEKEKKKTKNEIDGIKESVRGQDDESVDEGDFGRIEDDHNITDTDEISIRKRWLKRRLKTKRRRLSSRLLLMMGQQKPGLMLVVRVLERNLYLPPGMSFNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU31</accession>
    <name>L7JU31_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2469"/>
    <dbReference type="HOGENOM" id="CLU_1143237_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU31"/>
    <dbReference type="OMA" id="NICITEQ"/>
    <dbReference type="OrthoDB" id="10431459at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="243" mass="28396" checksum="672A0C0F55F49B18" modified="2013-03-06" version="1">MNSSVSLNGEFQNLLKEIKKLQNEQKELLTKLKTNICITEQLLMALLDRTHEGSLSNGDILNLRILKESSPDITVCTKLLHVLQQLRDRYNELLRLTENVFLNSARIVNTAFLVRIFLACQGTPTLGKIKFILKREMEGLHAHEIESQNVKRYIGVPSLHVRTNIIKQIANKLLITLKMDLNGKYDDLNLIRVRDAIRDDEKEERLDYLFKSKKKKRFGRKKRVKNREEMLKKIEENKTSWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUB9</accession>
    <name>L7JUB9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Argonaute</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUB9"/>
    <dbReference type="FunCoup" id="L7JUB9">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2705"/>
    <dbReference type="HOGENOM" id="CLU_004544_4_3_1"/>
    <dbReference type="InParanoid" id="L7JUB9"/>
    <dbReference type="OMA" id="FSRMHID"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="186"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="451"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="767" mass="87213" checksum="BF1D6C30A9FDE592" modified="2013-03-06" version="1">MATNMQLMQRPKNIQPGNVPLTANLLELKVPSLTLHHYAVLIEPVIARRLNPIVVSAIIQRHAQQFDQISYGYDGNTILVTSKQLQGDIVDVEKVGSTDVTIKFEYKNAHTLDDPTGMQCLEIMLRSYQARTFFVDGRKCVSAGDRSHVTGGIELWNGVTQRVKFFNGRLFLNVDVAFTPFYESMMLTDVLVKMCQRRRDEHVDLRRVDAGKFRALGKFLKSVRLTTVHRKNNPKFKCVDVTDKGACDTLFGDDNVSVAEYFAKQYRPLQHPYLPCVVVKKKDGNIFFPIEVVKILEGQKYTKKLSDFQTADVIRLSARPAAERFNCLENRIRSMHVTSNDVLTNINVQVSDRFYECLGKRLSPPDVLFASGSVQPSRGSWNLRNQKVVRGVAVVRWAVLVLADESVSFVNRQIPNLVKICNDMGVRMANPLEVRKVTLENIEEHIKGKELVMVILQDKSSFVYQEVKRIADLNCSVVTQCVRKQNVEKFRDGSFCGNIALKINTKLGGVNFTVDIAQDELIVFGADVTHPGFGDLSCNSIAAVVSSLDKHFSRYHTSLRMQPKRQDIVEDLKNITVDHLKRFRTCTTKVPRKIIFFRDGIGDSLMQNVYFREIEAIREACATLHEGYKPKLTFVVVQKRHSVRFKGDGRDEIVKDKRRGPTCNPMPGTLIDSVGTEYNDFYMISHFALQGTPCPIKYHVLVDENNIPNFPLYIYNMCHVFTRATKSVSVVPPIYYAHLAAARAKCYVNGDRLDETEERLKDVLYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUD3</accession>
    <name>L7JUD3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2720"/>
    <dbReference type="HOGENOM" id="CLU_829455_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUD3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="39170" checksum="1D858CB612BF3B14" modified="2013-03-06" version="1">MILRAERDKSNITTPVKTRLSFEEFVTIFGPIMSLLDPKYFVCLKEQEELIEAQNSSSCQFSLMRLMKCVLSLHCAFSVLEYVFLYIDGCPEIGTNRDVTAFKNFLEDPFSGLSASFKATIPGSPEAMEMEIVEDIVELIRLIETVRKVLLKYLSVNERMEKLIKFCEQAVKVRKELEKYEKEFWFYVRCEKARKTCFDAHSKGRMSYRSLYLYDMVSLKPKRGTTAKLTPKTKSDDPQRAEKSTQSMEEQRNIQAVQHTFAERREQFWLWYNEYVNSWTMVDISSLCNSLKYGDKEKLNMPTDPADSYKWFTALHSLSYFDNLTDTNSSNTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUD5</accession>
    <name>L7JUD5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2166"/>
    <dbReference type="HOGENOM" id="CLU_1877010_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUD5"/>
    <dbReference type="OMA" id="MVRENEC"/>
    <dbReference type="OrthoDB" id="10380058at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="16433" checksum="AC71AD4CB39FBE48" modified="2013-03-06" version="1" fragment="single">VHTSHPMRTIALLNRSKATVPKKVHWLKRNFLQHNDKIIIIALEEYTTTYIPAIHRCTWLPAIHRNTCTNTSVTYYKSLLKDLSNDKRLLVVRENECARVVEVLETYTIDVVVMGREFVDGDGKLFRMVCACMKMCVVMLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUK3</accession>
    <name>L7JUK3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2383"/>
    <dbReference type="HOGENOM" id="CLU_2656207_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUK3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8931" checksum="811843DF64C294DB" modified="2013-03-06" version="1">MISHSGPEECFVVRGVNRDIYSKKAKKYIGAELFVAITLYLHLKIFFFLQYTGIQLMNLHTNVYFSNNNNSSYYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUK7</accession>
    <name>L7JUK7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994029">
        <property type="protein sequence ID" value="ELQ74701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2365"/>
    <dbReference type="HOGENOM" id="CLU_381827_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUK7"/>
    <dbReference type="OMA" id="HPIVNTY"/>
    <dbReference type="OrthoDB" id="10399720at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="599"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="761" mass="88756" checksum="181388F573A4EF25" modified="2013-03-06" version="1">MNLFLLLFPLAMALELRTLVYQDKLRIYPAKKRGGKILPDFEQHRNVGLGVRQKKFVLQVESHLTVNDFWRLLGQKDDELAKKSHALQLNDKGLYMSLFKSPVDNVTLFSVILASLRLPENSHVNLVVDDTEVKKIAKDATQAFANVKLKLKYILPKTVVLALDGYVKGMIEKKYVLVINTSGEKGIFCLYTTDKVEETAKNGESKDEEKGKDEKEKKADNEPKEDKKKVINDGYALKLVFAHETDIISDITIRKIMYEFIRDSVEKAYNKFRTEERNLEPVEVGYYPFDDGKNKLEYYFLIEEIVDEMIQLVQKRAPVYVRIEIIIYNSLGKQIGVLTSQEFNLLDLYKQLDEYCDKNRSAVVAFEENLVNSVLKALDDKEVTADNLLQHIDVICHGVSMQLNLVKQFFKTIKIKNREFVTYYGSSGNYYQQYKIKDKRVYKVKNTPIISSKKYEDIMHELELYERSKDILGKCDKIEYDHPIVNTYKELWERIKRDDQELTVDNYKDFVRNYSRMAKEYEPEKLKMARTELRKQLKEVEALKKKEPEIYKAVKTTYDDVNDWFKEHGEKVETTYSNINDRKLDLMYTISAVRQDITIREMNKAKEKERLEAKKKAEEAALAKKKAEKTAVPIEEQESGYFTKNLLLTDANGFGFFKNLFGKQVDAKNLPQIQERKEFGESFDETKYEMNIPRLTGYSLSDEKDVLLPHDTSIMDMDDNMEEFMKFLRNSGPLMSKMDDTTHDYEKLLKGNAGETSKVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUR4</accession>
    <name>L7JUR4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1821"/>
    <dbReference type="HOGENOM" id="CLU_3242457_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUR4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="43" mass="5142" checksum="462FC311DD0F4A15" modified="2013-03-06" version="1">MIKRGAKKETNLCLHAYSMRFVEDKPEENVKMHANERSLLIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUU0</accession>
    <name>L7JUU0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar H+-ATPase V1 sector, subunit H</fullName>
            <ecNumber evidence="7">3.6.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.15" evidence="7"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUU0"/>
    <dbReference type="FunCoup" id="L7JUU0">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2449"/>
    <dbReference type="HOGENOM" id="CLU_602968_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUU0"/>
    <dbReference type="OMA" id="HFEESFW"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="333"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="448" mass="52644" checksum="C48D1EF6AECE645A" modified="2013-03-06" version="1">MEKLLEIEESLGNANMPNEDESNYDDIFSSEDLGKQHCYLLKMQNDILLDVLLGLCNKDDFYLKVKSIEIMSRRYSNALRDDPNSSFWTFVRATLTTEEDHEIVNFLLKCLRNFFLENLEREQIFPDLNTAVVFEKQDRKDSDRKDQRENVGDTNPNNACAPDNQSSKTDTGTCSEKDVDDINIILKCSKFIPYSQRYDQRERVESFRVHFVSDTAVQRRLLSFIETDDFCYNALFLIWLLSFTEKVFDKLSAVDLIEALENKIRKDTQDKIVRMACLVLMNLKEHDLFISLKNLHRMLNISKIMLNRKSEDLEYNHDKKELYNYIMKRIKNVSSVDNYLKELYSGHLEPTLYHFEESFWNVNLGKLQIKKHEIIKAIRLYLKRGERQNVVMALNDLFMFHNVDASIGRLIENYGVKEQLIELCGSNDGEIQFLALQAFLSVLNQQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV01</accession>
    <name>L7JV01_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1745"/>
    <dbReference type="HOGENOM" id="CLU_2211950_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV01"/>
    <dbReference type="OMA" id="ENAHNVV"/>
    <dbReference type="OrthoDB" id="10364779at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14441" checksum="0F726A6BCE3C1397" modified="2013-03-06" version="1" fragment="single">VWLLYTFLLVAQFICLVNHEICNISFSKKLNLLFHCHGMEIKTNDELLKDATIGLKKNIKDINNEITSQSTILEIIENKAVENAHNVVKARNKFEKAIESLKSDYRNFIILFLCSVIVILFIVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV07</accession>
    <name>L7JV07_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1862"/>
    <dbReference type="HOGENOM" id="CLU_1157140_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV07"/>
    <dbReference type="OMA" id="LYYCVEN"/>
    <dbReference type="OrthoDB" id="10396243at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="211" mass="24895" checksum="BCE1F47884E89A40" modified="2013-03-06" version="1">MLFFTIVSIIFAINDDEMSIEFCHVEDATKQLICQLDSIFNSVDCMRRLSQSAKQVCKYPKPTNFEFKKNPWIVLQIPENIEYYYGSLQHLSDNIGIFQMFFELSGLNKEMDVDMSYMEAIKKHMEKKQSMSDYIMKKYYNNHSDGIFLTMSRIITLNISKAMLSIRQLYYCVENGRIVDVCFIRRELIKHKCDKCEAKRKTSITNSKMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV40</accession>
    <name>L7JV40_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV40"/>
    <dbReference type="FunCoup" id="L7JV40">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1734"/>
    <dbReference type="HOGENOM" id="CLU_037460_3_0_1"/>
    <dbReference type="InParanoid" id="L7JV40"/>
    <dbReference type="OMA" id="LYTHMTV"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="272" mass="31169" checksum="B79AFB2D7B67772D" modified="2013-03-06" version="1" fragment="single">VLDLITSLGTDYLQPIKHLTIQKTLPMYTVLVIGSAGAGKTTFCLNLYDHLSTHNHNPTLINLDPSQQSNNTYHHDICTYITTQNVMEATDLGPNSSILKAFATMADHLENVEIEGYCVVDMPGQIEIFVHSESFLKTIAYFKGQGRCVIVNVFDFINFKSVERFLGNGVSMCMCVGRVELPFINLVSKCDLFLKDENDEDNLSEDDEDLCFDQLLLRTKFHKDLYQFLEHNSVLNFTRIRYTEEGMTDVIYMLDSVLHYYDDLDYVEPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-05-03" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVC0</accession>
    <name>L7JVC0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1863"/>
    <dbReference type="HOGENOM" id="CLU_1082540_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVC0"/>
    <dbReference type="OMA" id="CSICARF"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978836" evidence="1">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="257" mass="30185" checksum="CC571348677D9E4B" modified="2013-03-06" version="1">MNQVLFQFFFSLMITMIACSSFDDGEARQSRHQYITNPEITATNDSDSRNTIFRNFQVNESETSNEKIISCLMVYERNYKHMFNVKKVGSAKFEKLFNLLSFIWCTDEQNTLEQVRAMLLCRDDRKLVSYFGNLRTKLIIFARQTMSYREVMAEIEQNINSTKTVFDTVANYENFSNANFAEYVAELNKIFHSILLFKTKSEKIEAVKIFFDLIRKCIFNGDHLNPANQVTLDEISMFCSICARFKYIFLYNFSSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVD8</accession>
    <name>L7JVD8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVD8"/>
    <dbReference type="FunCoup" id="L7JVD8">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2059"/>
    <dbReference type="HOGENOM" id="CLU_064992_1_0_1"/>
    <dbReference type="InParanoid" id="L7JVD8"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="86"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="194" mass="21826" checksum="C071526AC885F057" modified="2013-03-06" version="1">MDIFTSRSVNVPIPKIKMFKEHWMEIYTPLVNIMGLQVRMNLKVPCVDLRIEDDNNQLCLEKGIQFLNAILDGFAPDQAVNLLKNGTCLVKFHISEIKRLSGDNVSRAIGRIIGREGKVKSAIEHTMGVCMLIKEDEIFMLGDEEGIKKAKESISRLVLGAHPGSILNKLKVIASKQRKGCFETVHLKNEENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVL4</accession>
    <name>L7JVL4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVL4"/>
    <dbReference type="FunCoup" id="L7JVL4">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1566"/>
    <dbReference type="HOGENOM" id="CLU_055193_1_1_1"/>
    <dbReference type="InParanoid" id="L7JVL4"/>
    <dbReference type="OMA" id="TTLCLCG"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="111"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="224" mass="25619" checksum="53C0F6D701DD0A83" modified="2013-03-06" version="1">MKKALLKVPDKHALTPALYKKRLLRTNPKNLHHKSQKAFREEVIQARKVALVDALKMPPALNQFKTFLSDDDFKEVQNLFMCYKPESKKERRERLRKEEEHGRVGDKPVIVKSGIRHVTDLIEQGKAKLVLIACDVDPVEIVLFLPTLCRKMGVSYAFVKSKYDLGRIVGRKSATTLCLCGVGADKRTKFDSLVKRCNSLFVEKYEIMMSTWGMPVNKEAEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVL8</accession>
    <name>L7JVL8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase, subunit RPB7.0</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="JH993954">
        <property type="protein sequence ID" value="ELQ75474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1578"/>
    <dbReference type="HOGENOM" id="CLU_179456_1_2_1"/>
    <dbReference type="InParanoid" id="L7JVL8"/>
    <dbReference type="OMA" id="GCRIFYK"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="6495" checksum="9A15DB2C1724D4D1" modified="2013-03-06" version="1">MIEEEHDQKKMYKYQCKDCKKLEIIGPKDPIRCGSCGCRIFYKLPKDESTQYDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVN0</accession>
    <name>L7JVN0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative E3 ubiquitin ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993947">
        <property type="protein sequence ID" value="ELQ75538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVN0"/>
    <dbReference type="STRING" id="72359.L7JVN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1509"/>
    <dbReference type="HOGENOM" id="CLU_880550_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVN0"/>
    <dbReference type="OMA" id="NCANGCF"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="316" mass="36737" checksum="9AE4515E1D1BCB1D" modified="2013-03-06" version="1">MNIKDIEKRTFFLIDQIVADLNDVDRKDELVALWLKYHNLVKSTCSNENQTFQIVENNRLDAKNVVDTLILDYLLRTDVHKARKFMRSASGNISEYWKMFEMKDKLVLLMDEQKYDEVLGIVEEKKKTDTITRFIFNVKSLKFMEMVHTSSTALSYLQSNFKEHSKADVLKLARILLTKQTNSRHEYVQQAKTLIPKLCTDLFNIPTFAALPIIYEIGMKSFQTLNTPEINEMLQTSCSKELPIDIALPKKYIFHSYVVCPVLKIVCDESNPPVLLECRHVISMEAVKRLNCANGCFKCPYCPVESNINNVYEIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVU7</accession>
    <name>L7JVU7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2179"/>
    <dbReference type="HOGENOM" id="CLU_2074783_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVU7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="13306" checksum="4B89041A9DDED1C4" modified="2013-03-06" version="1">MSSFDEKLKILTANNVPESSSEYITTLATLRQQSKLADITLGQNLEELIKYAMHAHPFIGKQRTMIPEQCHLCGTSSHTLYRMCQHPLDIPCAIKLYVTNGKKCPFCDKGLFIFLGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVW2</accession>
    <name>L7JVW2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative WD40/YVTN repeat-like-containing domain, WD40 repeat-like-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993942">
        <property type="protein sequence ID" value="ELQ75569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1473"/>
    <dbReference type="HOGENOM" id="CLU_1009005_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVW2"/>
    <dbReference type="OMA" id="FYDRIMK"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="276" mass="31715" checksum="3FA68B766DD7FFF1" modified="2013-03-06" version="1">MYNLVNPYLHHFRDIIVHNEKMLMLADNGNIYDLVTHKKILEIDGSVDVAALKDDNLVMVVDQHIHVYSLKTHRRRIIEKQIGEYSTAIYYNEILAVGTENGDIWLFGEDFVFLTMIKAGKEKIPVIAHNGTGIVAISHSGELIIYDYNSKKLITKHFGSKLTAMTVQKTKNDTRILLGDENGFVYFVNHDLSYKRIRISNGEIEYLYYHESIYCITEGFVRKINDRGAGKIYGTVCSIPTKVFSCNKKVFCTSVLVGIQPIVDRKNDFYDRIMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVW6</accession>
    <name>L7JVW6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related small GTPase, Rho type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVW6"/>
    <dbReference type="STRING" id="72359.L7JVW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2143"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="InParanoid" id="L7JVW6"/>
    <dbReference type="OMA" id="GDEPYTF"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="200" mass="22621" checksum="4CFE7C6A4A2740BB" modified="2013-03-06" version="1">MSMLKKQIVSKVTMIGSGQAGKTSILLRLIDDTFNKDCEPTIFENKMITIVVEQVPISLHIWDTAGQEDFNSIIPLTYESTEIAIICYSVDDAYSYEAVTEKWENEVRYYSENVEIVLVATKIDLRNDGKASCLETEDGRRLAKQINAIAFFECSAKDSIGIPEIFNFVAKHIYAKKVVNQPAKSKKKKGFFHALFQKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVY6</accession>
    <name>L7JVY6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1908"/>
    <dbReference type="HOGENOM" id="CLU_2905761_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVY6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7120" checksum="5CC21CE63D51DDCB" modified="2013-03-06" version="1">MKNQQNAFFSYNSPSNKLIVSPFRRMVHEGGVFAVLKKKRKDLLSKFDPDSTEEGINEKGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW12</accession>
    <name>L7JW12_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2109"/>
    <dbReference type="HOGENOM" id="CLU_3368785_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW12"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="4249" checksum="9CB9F4353736D98E" modified="2013-03-06" version="1">MVKAIAGWKRELMFFTDDNEEERRMCRNDDDKIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW18</accession>
    <name>L7JW18_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1844"/>
    <dbReference type="HOGENOM" id="CLU_3144011_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW18"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5813" checksum="F952E8302D4CF206" modified="2013-03-06" version="1">MMIRKVQVTVIVGLVTRKFRNVDIDRLILCRHQLMARLEVWYNSLLGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW26</accession>
    <name>L7JW26_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA mismatch repair protein-MLH1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW26"/>
    <dbReference type="STRING" id="72359.L7JW26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1405"/>
    <dbReference type="HOGENOM" id="CLU_004131_3_2_1"/>
    <dbReference type="InParanoid" id="L7JW26"/>
    <dbReference type="OMA" id="CAHRASF"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="162" mass="17870" checksum="3B123593623CFEEE" modified="2013-03-06" version="1" fragment="single">MTIRKLPPSIINRISAGEVITRPLSVIKELLENSIDAGASVIRVGYAENIVMEDNGSGITEDDFELLCARYCTSKLSDECDKKRDILDNVCTYGFRGEALASISDVSTVVVRTKTTNCAYGHVLVYEHGVLISKKKEAMKNGTMITVKDLFGNNAMRKTLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW57</accession>
    <name>L7JW57_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone acetyltransferase PCAF/SAGA, subunit SUPT3H/SPT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW57"/>
    <dbReference type="FunCoup" id="L7JW57">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1773"/>
    <dbReference type="HOGENOM" id="CLU_094300_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW57"/>
    <dbReference type="OMA" id="ALMPWDE"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978812" evidence="6">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="286" mass="33574" checksum="057E2492ECF52191" modified="2013-03-06" version="1" fragment="single">VKIYLCTFLKLTIFITGLSSSPSMNYLYTNEIKAMLYSFGDSKNPSLQTAQYLESVLKTQIQRFLSAANNIRICRRGKLINLEDIGFVIRKDPFKLRRLLNFIHFKEIKGKLESKLEFHSSEAEFTDIKPLCEDNVENKSDIDSNSAKIEPDIFKITNDEKKFSWMLPVQGTDTFQLNRLLEIDNLTANMSKDEYLEFAECRQSSFVYRKNKKFREFIGGWRIHDNIMDVLGYICYEMVYNIATMVLTLRDKRRGYKVKFGQSIPISTDEIDEVCWLILKENRLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW58</accession>
    <name>L7JW58_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1360"/>
    <dbReference type="HOGENOM" id="CLU_057187_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW58"/>
    <dbReference type="OMA" id="RWILCFK"/>
    <dbReference type="OrthoDB" id="10502308at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="403" mass="46531" checksum="CF588EF04D7EB0EF" modified="2013-03-06" version="1">MNVPDLLARWILCFKNETSGNACESLICDNLKETHLSSVVKDIFESKIASGHKFKAEEYDTSDDPLGIFQKDENSCTTSTPQTNEQTSDENGNSCVFESKTQKYMRLDVPVTKSLYMKTTKLSENNDIDLTDSEIVEFMEHLMPFLDDNSLILQLICQKLMNDYQHFEDRIRKVYCDKYSNVKRSRESSSLIFDLHYSDLIRKIQSVIYFYVKDKSGNVALFSETEDMENRLPVYTNLTNIGELFVPHFLKTDKNFLMKNHEHLYLLYRDTLPRNTDLVVKISPTKDFKPDTCSACDNLRNNTVEAVINILKCGFICSNWVKKLIIEFEKTESNLDSNFFGEKDINSQSDSSPMKKNIILPGNLTKVYIRNPPNNISFDIPDTLKVFVLRKNEFTTGCRINVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW84</accession>
    <name>L7JW84_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1395"/>
    <dbReference type="HOGENOM" id="CLU_1429032_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW84"/>
    <dbReference type="OMA" id="IVFIEEC"/>
    <dbReference type="OrthoDB" id="2187509at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="199" mass="22559" checksum="B1EF5DEF5C9B819B" modified="2013-03-06" version="1">MEKFANFNDPITGQNPFAPLPLKQPTLLRAVHLIYRVPLFILFLIGINTVPMLITIKCTRTAYKKMVCNSVSVFDTFVLRHLFPGHAQLYDVNAFTEYDGAAILFIEECASNGKMVTKFKSDVRCDGALFMKYSNECVYVMGSMLQFYWRFLMCDGRVSVKVCELRHSGEYARVIGVAKSVLGVNEKNKFLAKTGRAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWE3</accession>
    <name>L7JWE3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993932">
        <property type="protein sequence ID" value="ELQ75729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWE3"/>
    <dbReference type="STRING" id="72359.L7JWE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1315"/>
    <dbReference type="HOGENOM" id="CLU_1157145_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWE3"/>
    <dbReference type="OMA" id="LDYQIRY"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979089" evidence="5">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="243" mass="28878" checksum="0FF6660E591B45FA" modified="2013-03-06" version="1" fragment="single">VIVMNHILLIFMSLVFAERVYILDEHKPRNFVSRVRKDFYSIFAPPRRNNKYVSVHKLRSLSSGKKEFNELLLDYQIRYQILKNQSDDHPDLKDDFENYLKEIVLVFRMLYKLRTSDNYSYVKMEKLSADVKKMLESAEALFNKGIKTNRTKHEEKELVRELNVLKYDLLDVAICDEISGKRSKRYSSECPICYEDYDLVYTPCGHGYQLPCLYKWMLEKRTCPYCREKLLPDVDPADGLDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWG7</accession>
    <name>L7JWG7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993991">
        <property type="protein sequence ID" value="ELQ75092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1966"/>
    <dbReference type="HOGENOM" id="CLU_2312985_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWG7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="100" mass="11941" checksum="A561083F44B43599" modified="2013-03-06" version="1" fragment="single">VDDRLRRLIGKRSYAMQRRTNWSKYDYCRLLAAKRHYTKRADYHMQILNDPRFGFCGTMSLVKLCDCMKHLNAEKHWHANDENLMSAANDYVPSFIARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWH4</accession>
    <name>L7JWH4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1649"/>
    <dbReference type="HOGENOM" id="CLU_1113654_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWH4"/>
    <dbReference type="OMA" id="TFCRYIH"/>
    <dbReference type="OrthoDB" id="10366995at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979091" evidence="2">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="260" mass="29822" checksum="747035CDC00D5946" modified="2013-03-06" version="1">MQSLRWPSLILVLIAFITAGLQYVTPTLPSLTNNLCQLLQYRISPEFFPLILAFTVLVVPVFISALIMRTFCRYIHESRRSLRKTHLVSSFFYVFSICTNALLFTMLMYTMMSFSKSPGNILFFMTKRHTTVQDAVFNVNVLFTIVLFMNAALYIVSTYVVESMEMRRINKINDFSALILDSSYISTNFIIALVALVMYVALILVYTVLFYTLLSSFRVFVQPMVYCILFAVLSHVLFVVGYTTHTNVSLEKALIANDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWI9</accession>
    <name>L7JWI9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993917">
        <property type="protein sequence ID" value="ELQ75843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1195"/>
    <dbReference type="HOGENOM" id="CLU_2335130_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWI9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="98" mass="11042" checksum="FA54132A3E073533" modified="2013-03-06" version="1">MEIVRNTIKWVLCFASTTPDGKHDIIVCDSSDGLPLINLLMDISDLSWNSRNVFDSEWYDTLEDLLHSIGEVECEDNITADQESNEIAVAHDTSLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWM1</accession>
    <name>L7JWM1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1597"/>
    <dbReference type="HOGENOM" id="CLU_320083_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWM1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="866"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="907" mass="101960" checksum="17A5D1C952C76D80" modified="2013-03-06" version="1">MFILLPVLVFTISLPRKKSPKDEVLFKISNDELEKIVVIDYEVIQTIEDEMLRALINSYLDCFHNFSDLLTNAVSQYFTEIPALDVDFEPKNIQMVRPTMLSRMTINNQDNLEIAVNLPKLGKKRQRHELEECKLDQISKEIRLQVPGKKIVANNLKQKCKQERNLTSTRKARIEREKSRHTRMNHNNDSSDSDSTCQTLTPGLCSVQLGLNLVQEELNNLKQKVDSLLEKFDDHVIKRPNTLDLMSQKKTFIFGDNDDRGQLIDDAEDMHYNNTCINSSTMEESETYMSANEYVSSAGKMSTEQEDETRIPKLTNSNLNHYPASSDNNIDQFYPYTQRSEIKWDLACDNKQYRDILNRPVKKLLLSSSTCEAELGHQNVFDSNYHPLDDHYSKEHANLTSERDIFGKHSRNISYTDEDESLDALVNRAGDVERTVELYQRNKSGGFLEPYFSSHLENADSEECVKGDSSPVAKNLDALKDADIMENGEVKLGYGSNGNRRVGTESVQGLSQDIDKVMRTARVEKLPGDETALLLGVNKLVPAVYELVSAIGSKESFVPKGVVEPVRPFQMIQVDKKKSCGESNDNFEGNNGTVYNQKLEKKQLIAQPDVARNASAELENGYKPQSIMSNLCDSSNVHGQSVIFGIDEAFNADQRVYSPSEIPERQVFFDNVVAESKEASAKLPTLNLHYSSELVPGISPDSENEYDIFTHGSSLASQLQDVSENVSSIHEQSIRYGSRLPTTAVPIGVNSVHQVPLGSFLSYTEAGINSPFSIYTPSYHSLHTDSEDSSRYHSTKSPDEYSRTNFDEGDAKCDYTNASNDNIVQEPAVSSDDVENFLTDDSLTCMDNSPPQNTISEPIESLCNNEGMISDNASKRSSDLLYQEQPESNDGNDDPSMHGRRPSLTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWQ5</accession>
    <name>L7JWQ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993933">
        <property type="protein sequence ID" value="ELQ75725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1318"/>
    <dbReference type="HOGENOM" id="CLU_1369219_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWQ5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="200" mass="22397" checksum="9EB6562B658EAF20" modified="2013-03-06" version="1" fragment="single">VCSSNMCRAFMVCVGTCVTAYVAFKDVLCFSVFDHITPSFLKIFDQLKHPFSSAKKTVPVTTDDQFFQDIFGEEVECSLSADFSVVNGQFESECESHTQDKHRNSDKKIDSPNFSVSTSNTATNRTSDHEDHAEELENNSKSSDDMMECSWNIPKFEEHLKLTSGTVKLEELSGTEHECSLELCLSEEYFHSSDSGHGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWR5</accession>
    <name>L7JWR5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1547"/>
    <dbReference type="HOGENOM" id="CLU_700571_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWR5"/>
    <dbReference type="OMA" id="IHNTSGF"/>
    <dbReference type="OrthoDB" id="2196308at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979209" evidence="1">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="354" mass="39375" checksum="8F78F53F75CB639B" modified="2013-03-06" version="1">MQHTLLLALLMPLYYTSDLPTLDDAHDDCCEADCFEPRGCNLKLGDALLSGENSRRYRAETAKCIWDKTRCEDTKEQVLPCIVRYSSTAQKCKQTEIDIYIKGVCCFLRANGCTPTQEVCELIRLMFAFFKGDVRRTTILLAHCIHNTSGFKYLTGADESAQVGAYISRGILQIRGKENYRLADQNGFFLRCPSRMAALDSMANEGALNVYAAVVKVDDQLTFIDSWVALNPLEVQGTNYQLPYFQKIIIGRLNVYLALCQTLGLPVYLGSTARLFLSFCEAYLRDACNRANSVIAFKTGASRHAHPYRNDCAPRYTPNAYSGTIIGCGTFECGTGYPRGRSASGCGRTPVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWT9</accession>
    <name>L7JWT9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative WD40/YVTN repeat-like-containing domain, WD40 repeat-like-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993898">
        <property type="protein sequence ID" value="ELQ75948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWT9"/>
    <dbReference type="STRING" id="72359.L7JWT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1085"/>
    <dbReference type="HOGENOM" id="CLU_382258_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWT9"/>
    <dbReference type="OMA" id="HFYRING"/>
    <dbReference type="OrthoDB" id="10387440at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="724" mass="82712" checksum="0AB99930EFC345A3" modified="2013-03-06" version="1">MTTLHKNFRKIRMLNEISSYGSIITEKRDNASYITTFTQTSYTTFDTKHLNTVFIGPLFTRVVCYDKYMDELVVCTDSLICVCERGEIVRSVGYAELGVSRAKMVVCLADCAVILADDNEIITIGYDLSVRRRTALAGAYLMKRVGAKNKLVMLCTNRAVLCRIDSGEVVCTYELHYKATCMFVCGYTCVIGTSTGLVTLLCLKTGEFVKMAQFDVQVRDVCADLESGMVAVCDVKGVLHFYDVKTGVVVDRMVDVCRVEWVDEFWVVTRVNNGGYLRDSGENDLMMWAGNDSGGVIERNGSKDDVVNDRLVGRVIEGGCAAGKDSFVNDKRVDNKNERVVGNGLQAIKENCNRNGDVFVTGTLLNESLAYADKPPVDLFKIDLELYKSENYKLVLSKCRRTFGERIVGLGNYTRRNMVLVGERGAFNVGYYRDEHSFRFKMQRMVSGWTEFNKIRYYDIKDRIIIGTACSISELDHTNKREMVVFRTYNERILCMALSECSNFVIFSLGNVVICLNLTSSLIYKRIYLKNVIGVAMSLFRDRILLYDGCKVHFYRINGLKLYEMVVEGTQFVTMVLIENVLVMRYAKKVVLIDIENQSLVDEILFNDEIRDMCISSDFKRVGLVFERYAAVYELGSNSLIDKFNGTYDRILFSLHNEFVVLSNYNMVELYADENWFCNERMVDKVFLDDNKHNVRDDDGLVQEENDNLMIEVLSYLEFERKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXA5</accession>
    <name>L7JXA5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Integrase, catalytic core, Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993899">
        <property type="protein sequence ID" value="ELQ75945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1089"/>
    <dbReference type="HOGENOM" id="CLU_2759599_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXA5"/>
    <dbReference type="OrthoDB" id="2193507at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="70" mass="8221" checksum="3C06C0A9F7373E36" modified="2013-03-06" version="1">MVTNPGKEFKSKLVTSFCEENGIEYHVTSTEHSEANGRVERLNRTIREYIRKRSNPKIRQKNDKRSLISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXB7</accession>
    <name>L7JXB7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXB7"/>
    <dbReference type="STRING" id="72359.L7JXB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0909"/>
    <dbReference type="HOGENOM" id="CLU_634917_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXB7"/>
    <dbReference type="OMA" id="RYTIESM"/>
    <dbReference type="OrthoDB" id="10412886at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="422" mass="48745" checksum="6245735FA1C94F6A" modified="2013-03-06" version="1">MTIKKDDYVIIEGYGRASAPLKIEDKKCKFNRQIFNLLDLEGLEYYVTYKIENEVFKLVDMLEPLDEDTGNTDYDKKYVDANNNTTKRLNVSAGDGKCRENEDDVHSGDAGEKEEITMEERTRRKYRNKKNEKKEKRIIVHELSPLSFHSSLLKRKKTFSLSAIAFLSFYVEKDRSVLIYDDKHALLSYTALYKGVKTVDVVGMKQSVKKVGNYIIKYTTLNDLSSVYDVVILADICDASENQQLCERIHSHLSDQLVIYRRNRDDAEKCFEYFLNHKSYVNVRMNDFFSRRYTIESMHPVVRGDYNEGYVITANKVVDVMECLSAGKKQPAFEEKKHLSVDEIMAGSMVDNNHDINEKDDGMHPRTRSDNSNNDTDGEMKNSEKNETFVCYHAAASQADDEGMEKMDDKDETHKRKRLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXD4</accession>
    <name>L7JXD4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1358"/>
    <dbReference type="HOGENOM" id="CLU_1504497_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXD4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="179" mass="20421" checksum="78983C1EB6873FFB" modified="2013-03-06" version="1">MLLLVKNIPRYTSYRLLFDALTKDLCVSKKYIKLAYKPGKAVGYLRIRNKEEFLVELRDNDKPIVHEDGKSNNILVKDTEQVGENAEENKIKTMSDVEVGNMDNDKLNNICDIVSKGLDSANDALNDKSLENIAKNGFNKNEELSSVQSRDVGESLNDKLDMKIFEFLCRKEIKLGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXE7</accession>
    <name>L7JXE7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXE7"/>
    <dbReference type="STRING" id="72359.L7JXE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1373"/>
    <dbReference type="HOGENOM" id="CLU_1005388_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXE7"/>
    <dbReference type="OMA" id="YDFRFIL"/>
    <dbReference type="OrthoDB" id="10315153at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="277" mass="32794" checksum="FB522B5EBA497B4C" modified="2013-03-06" version="1">MDVLRSLLTDGYEISDKKIIADHKIIDNKYIEIEEKTYTLLQILFYVQHETMPFEMYAKLALENDIPVVDSKLMYYLAEKVYPLEKYDKNKFNLQYDFRFILNHVVRKEYVILVPASYSSKINIFNCLNVFSTGSFKNPPLDIKNMLVNEHKLKRKMEMCTANFIFMTKWHGTVHADVVAVFLDGSEWQISTLLDVYKDKYDETRRNNDFDINQSDDFFGGRSKWACPVYFVHTADQQICNTNYEFEDVLVENEAGNFGLVNKIWRDIENYLKRTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXG0</accession>
    <name>L7JXG0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">26S proteasome regulatory complex, subunit RPN8/PSMD7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXG0"/>
    <dbReference type="FunCoup" id="L7JXG0">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXG0"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1003"/>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="InParanoid" id="L7JXG0"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="1">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="286" mass="32888" checksum="B68A34617FFD60B4" modified="2013-03-06" version="1">MTQPTADGDGESKCNKRNEGGTMMQRNKVIVHPLVLLSVVDHYHRVDGTRVVGVILGYKQKVKNSNSEYQTEIHITNSFAVPFDEEYNSNWFIDTSYLENMFELFFKVNGKEKILGWYHSGPDLFSNDLQITQSFLRYVEDPYLVIVDVKSTTKGIPVRVYELEDDNFKHIFASIEAEEAEEVGVEHLIRDIKDDTYTPHFESYKDIKDSLNVYSNNLQAIINELDNIINNNSPMNESLIFSFKECLSSVLKVSNSTKINELSNYVGSVTKTFILTNDLIRNRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXP8</accession>
    <name>L7JXP8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase II, fourth largest subunit</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXP8"/>
    <dbReference type="STRING" id="72359.L7JXP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0789"/>
    <dbReference type="HOGENOM" id="CLU_110332_4_0_1"/>
    <dbReference type="InParanoid" id="L7JXP8"/>
    <dbReference type="OMA" id="CQQHTRV"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="112" mass="12782" checksum="D15A97F4CA3804CF" modified="2013-03-06" version="1">MVQNTSHPLTISEAFHHLASQRPRIIKKDVKFRTIFENTYNYCQQHTRVSSTSLMENLRTSLIELGLNEDEVAIVASLFPQSVDEVRLLVDSLGRLDEQTLIKVINKINSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXS9</accession>
    <name>L7JXS9_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Putative WD40/YVTN repeat-like-containing domain, WD40 repeat-like-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1495"/>
    <dbReference type="HOGENOM" id="CLU_393391_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXS9"/>
    <dbReference type="OMA" id="CSYDIMK"/>
    <dbReference type="OrthoDB" id="2200860at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="701" mass="80119" checksum="6BA156282455546A" modified="2013-03-06" version="1">MEEDFIPNFIYMAQVGELANEHSTLSYYNDHLLISRNNSLEMWDIRTKEVVKRIGTYKKEKISCWCVADGLFVLGYDKGIVRAYNGDNTKMFGFRWGTRRITSLFYVHNLLLIGNAARTCSYDIMKNEVVMEYEQHAASKLPASNNTTCFVRYAGNTFYVYQYGTAHPVHVYDALDVISFCVVGDALVFLDRNGEIALFDLRSKALMKNRLKIKKAHTVCNVNDELFVLTGKKVVYRYEIIDERVINEKDRENDGRSDDERSDKIVDGSIDKTVDGRSDRIVDERNDNREKGLNENVIDEKDLNDREKNLSDKNKGSPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKNFDIKLFDYNDDYLVAAGKYSVYLYEMDRYELIKDSSSESEDELEIENLKVYDKFSRALERSKEDADYDALFNAIKELDMGDISSIISGLDNNSLYVVLQALMNNIDYNVVLAVKVFFSIVEHHRYFVAENQSAYVVYKEIRGRVELLRQLIKENEYKIGINGVMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXU9</accession>
    <name>L7JXU9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0901"/>
    <dbReference type="HOGENOM" id="CLU_2564820_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXU9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="82" mass="10093" checksum="AB33FE3E71C6BF70" modified="2013-03-06" version="1" fragment="single">VMRILFENQICMWLSKCPHTKHVLLPYFMKYRNKYEKEEPYELNTRAYIYLVCFSIFFSVIAGIVVLWKTIYPSFRMRLSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXX5</accession>
    <name>L7JXX5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993869">
        <property type="protein sequence ID" value="ELQ76150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0884"/>
    <dbReference type="HOGENOM" id="CLU_1897666_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXX5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978966" evidence="2">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="134" mass="14942" checksum="EEA3FCBAE804F9FB" modified="2013-03-06" version="1">MNLGRCHMVTISLFCIANTILLKNFVGTVKYGEEMRNSAEEENESVNGNEVSVEKTVIKNRMVGMLLDLAGIQFSNETSGRMAASNIKKDRLEDTKHKKKANKKYLAHGEDVTEESVTSSFTGTRNKKVEKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXX7</accession>
    <name>L7JXX7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bZIP transcription factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXX7"/>
    <dbReference type="STRING" id="72359.L7JXX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0723"/>
    <dbReference type="HOGENOM" id="CLU_1332758_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXX7"/>
    <dbReference type="OMA" id="NEMWNQR"/>
    <dbReference type="OrthoDB" id="2187714at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="206" mass="24529" checksum="1252E172F77526E5" modified="2013-03-06" version="1">MLKKEKLKFTKYSGKMMSHPNNISPNDISSMRKKESAQKMTYDDATRINLANVGQHKVDIVQDGVPNTYDMDIFYMKSIWKKERNRLAAKKSREKKAKLMKEYELNEKKSIQEIMLLKQAIYDYDNILKEFFVYIENVLNDNNVHGDNLVALFDFLCRLKKPGKDYYIENVSSCMERSLMVTNNQIYTLTIKIRSRLNEMWNQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY10</accession>
    <name>L7JY10_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class 2 transcription repressor NC2, beta subunit (Dr1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993856">
        <property type="protein sequence ID" value="ELQ76314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY10"/>
    <dbReference type="FunCoup" id="L7JY10">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0716"/>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="InParanoid" id="L7JY10"/>
    <dbReference type="OMA" id="RDAKFKK"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="16923" checksum="5E01DAFD4198E4ED" modified="2013-03-06" version="1">MTRDDNKPDDDLSLPRSTIDKMLSTYNLSIPRQVRDHLTTYLHQFIHHISSDANLLCEKEKKKTITHEHIYEALRTAGFAHFIVECQKVYDETLNLSKMRPSRINKLKSSKFSIEELRMEQKKLFESARKEYENMEFDEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY31</accession>
    <name>L7JY31_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY31"/>
    <dbReference type="STRING" id="72359.L7JY31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0810"/>
    <dbReference type="HOGENOM" id="CLU_1111998_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY31"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="250" mass="28856" checksum="8D3893A302F64D26" modified="2013-03-06" version="1">MLFYVLLVEQISDTKIRIYGKEGRRTDDNSGIIYGNKMAVTLTIEPEYLHYMGLIDKADLLNTNYQTVTRKNYFYTDLPVDLELIKCNKKTLKGAVKSFSEFSSLTEQFIITRKIKGPGILEISDICETNTELITKEENVKFVEHAEYPPLIVGAVFVLDTMLKVNLYRIEDKKHIFIKVINFTDVRNESIDVLVHHNMHLKAIGGVWVIDTFECAKQLMRGRSFCLDEILGRNISENVTKNQHTEQQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY61</accession>
    <name>L7JY61_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein SEL-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY61"/>
    <dbReference type="STRING" id="72359.L7JY61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0687"/>
    <dbReference type="HOGENOM" id="CLU_000288_126_3_1"/>
    <dbReference type="InParanoid" id="L7JY61"/>
    <dbReference type="OMA" id="YENYICA"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="389" mass="44509" checksum="E86D6879C9591DE9" modified="2013-03-06" version="1">MEKQISSLVVKKNLTDYERAFKSNNMMAKLKFIYKILRKIEDNRENLCHVMGISDPALTAGKNSKKSEPNEMEKACLEVLKSVLKGYAKNNTPEKELGLAYAYMGIAYEIGAFGLEINYKKAYENYICALKKNHGMGAFRLAVLFEKGVHARRSLTKAFAYYRCAAKMGLSEGMHAYGMILYYSEDEDVRDCRTGFHYIKLAMVNASSEYPHPYFDLGRIYETGNTTLEIHKDLQYAYKTYVRGASLGCPNCCYRLGRSYEFGELNRSKSWKEALWWYKKAADLGQVDAQMALSTFYITGIDRVLDVNYEEAYQWTLKAAVGGHAGAAYSLGGYIEKGIGIRKDPAHALWWYSISGLFGNKNAKYKIEQLSNDVYMNTTRKKRWWFLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYM1</accession>
    <name>L7JYM1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative snRNP core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993844">
        <property type="protein sequence ID" value="ELQ76529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYM1"/>
    <dbReference type="FunCoup" id="L7JYM1">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0489"/>
    <dbReference type="HOGENOM" id="CLU_130474_4_0_1"/>
    <dbReference type="InParanoid" id="L7JYM1"/>
    <dbReference type="OMA" id="DNISCTD"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="119" mass="13740" checksum="3D233C04AB5DD57E" modified="2013-03-06" version="1">MHFYHNQTTLPMIFYMFFQKNINKNIIVELKNGLVISGKLLSCDIFLNIKLCDVTVKDLENYRGLSGVSTLSVRGSCVKYVKLEKDEDLIASLLETTRNRFIVNEIREEAEKESDSQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYM2</accession>
    <name>L7JYM2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding Cassette (ABC) Superfamily</fullName>
            <ecNumber evidence="10">3.6.1.3</ecNumber>
            <ecNumber evidence="10">3.6.3.25</ecNumber>
            <ecNumber evidence="10">3.6.3.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.3" evidence="10"/>
    <dbReference type="EC" id="3.6.3.25" evidence="10"/>
    <dbReference type="EC" id="3.6.3.28" evidence="10"/>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYM2"/>
    <dbReference type="STRING" id="72359.L7JYM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0902"/>
    <dbReference type="HOGENOM" id="CLU_020421_1_1_1"/>
    <dbReference type="InParanoid" id="L7JYM2"/>
    <dbReference type="OMA" id="STHMMEL"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF116">
        <property type="entry name" value="PROTEIN BROWN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="13"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="491" mass="56920" checksum="65BA88205D919EDE" modified="2013-03-06" version="1">MTRMKIEWQHVYVRLTLTYGVSSGTNFCVLSDMCGEMEEGLLAVMGPSGCGKTTFLRMLAGRVPSGSITAGYVHYNGKERNIDQWLNNIAYVGQNDVIYKYMSARDHVVYSALFNRKKIRNLKQKIKLLFDRLDITKLMHKKMDKLSNGQRKRVLIAMELIKEPDIVIMDEPTSGLDNTSAFYLVQFLKEYALSGRIVICSIHQPDERTVNVFDRILVLNTGHTIFLGKKETCEELLRQNKIVRSPFMSFSTHMMELCWSENDGFYDANSMLRLCEIFNENQLKYSKSADRIPHFKSKDDFYLNMWINPYHIFLLLKRSMHARFSEKSALVYIAIYNTPLPVFILFEKFYLRSDKFDFAALDALPSNSPNLQQQLEDIIGYCNEFAHYTDQAYRFTIMLISTSIMYLGISDLPRVCNELALNRYSIVSYYFGSMLDGISVFIPPTTIGLLSMNIFVDAIFDMRFVFLSILFILHACIYMYFFQNLFKGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYM5</accession>
    <name>L7JYM5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993837">
        <property type="protein sequence ID" value="ELQ76563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0457"/>
    <dbReference type="HOGENOM" id="CLU_2948396_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYM5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="7048" checksum="64D5BA612BB60B00" modified="2013-03-06" version="1" fragment="single">VVANHDTSKIFKIVTVSYTKELYEKAVKLDGENCFSFSLDETRLIYRYIFLNLDKKQKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYS2</accession>
    <name>L7JYS2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Homeodomain-like, Homeodomain-related, Homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYS2"/>
    <dbReference type="STRING" id="72359.L7JYS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0497"/>
    <dbReference type="HOGENOM" id="CLU_1305701_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYS2"/>
    <dbReference type="OMA" id="DYINCMM"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000020">
        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="211" mass="24738" checksum="A97A8732162F5B75" modified="2013-03-06" version="1">MDKSSYFNSFHRNSHGELKSTFFDPFVVKHRKRTSKTQLKILEKTFETNIKPDAVLRNQLSEQLGMTPRSVQVWFQNRRAKQKKAKNKCKNDNRENHSQNGNIPKYDYINCMMPPPDESMMFMPIAPLEKTTTFCNDRYPISPVHDKALKKMAQNDHYATRAESTQKSDNKMEYPPVDTLDSSWIDMRPHYENNEGIADNTISFDPNNFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYV8</accession>
    <name>L7JYV8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYV8"/>
    <dbReference type="FunCoup" id="L7JYV8">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0817"/>
    <dbReference type="HOGENOM" id="CLU_017374_0_1_1"/>
    <dbReference type="InParanoid" id="L7JYV8"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="2193092at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="11">
        <location>
            <begin position="330"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="451" mass="52421" checksum="F110E51483413734" modified="2013-03-06" version="1">MKNFYDPSEMDDVISLDSLFLLSTNNGDENINLKLADKGIAMKNIENGAITTIKKDDIHRIELYRGTRLYNMRITTKTKIFNINNILEEKIEEIKKVCGHWYSINVYVKPLEIVDTTKGKVTFSEDYLEYRTDKLIFDVPLKDVVSVCSVKNEAVLGFDCDKEFDGVIEMRLSVPDENFVKNLRERSEIGQVKSIITFETLNNVSPRGKSDYIFSENYIRILGRTYEHKVLYSSIKKIIVLEQEKVVNIIINVDPSIKQGQTRYNFINLLFEKGIDEDFELELDSDLRSKYPSLEEKYNGELYETFIKIIELFTKQRVQVSECFKTRTNQIFLSCALRALEGFLFPISDAVIFLPKVIYMPHREIRLVEFYRVDVSVMTSKSFDMKIITYDSSYLFSSIDKDEFGALEKYFGDCNVEIRVEIVENEIPPEEEDDTTEIENEPSLEADESDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ06</accession>
    <name>L7JZ06_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ06"/>
    <dbReference type="FunCoup" id="L7JZ06">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0720"/>
    <dbReference type="HOGENOM" id="CLU_143122_1_0_1"/>
    <dbReference type="InParanoid" id="L7JZ06"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="72" mass="8466" checksum="0A2DB5C889A4F956" modified="2013-03-06" version="1">MLIPVRCFTCNKEISSLYEKYVLLLKADYTECEAMDKLGIKRMCCRRMVLCHVDIVDKLLKFDTTQDINTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ31</accession>
    <name>L7JZ31_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M7GpppX diphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ31"/>
    <dbReference type="FunCoup" id="L7JZ31">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0383"/>
    <dbReference type="HOGENOM" id="CLU_041045_1_0_1"/>
    <dbReference type="InParanoid" id="L7JZ31"/>
    <dbReference type="OMA" id="INDYKWD"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="31123" checksum="F10A6E19B14D9EDF" modified="2013-03-06" version="1">MFSFILSHKSANPDSVMESLTNYEILSCRGNNTVILGTLNDKLSIVLVQGKEIELNEIEKLKTEKYEVTLMITPYMRMVSAHYTLRVISPCSEHHIKKYGKPKYRSETYDEYLLYLQQDKLSSNWIQKIKDGEYEIPIHVDSRFIVINDYKWDMSDVSQLYLLLIFKDQGLFTVRELNLNLIVDAKKTALQVLNTIYGLSEQDVLMYFHYRPSYYTLHLHIVNLERKMEYGMMVGRAILLDDVIENLKIDPLYYQKRKLFYVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ32</accession>
    <name>L7JZ32_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">60S acidic ribosomal protein P0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ32"/>
    <dbReference type="STRING" id="72359.L7JZ32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1025"/>
    <dbReference type="HOGENOM" id="CLU_1462331_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ32"/>
    <dbReference type="OMA" id="CMTANTF"/>
    <dbReference type="OrthoDB" id="2193036at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="21126" checksum="6B6D3FD25FF6FCBC" modified="2013-03-06" version="1">MVAVSKKEKNAVHYTKIKECLGKYNQIILFEMNPVRTNVLHKMREVTRDTTKIIFGKKLIIRKALKDVDDDFLKCMTANTFLVFTNEDTSKIVDVILKYNVASSEKLIPKGILKINNVAAPTVIKKNLDKLNFVTKEKNGVLMVENAVELDTEKDKKLIKLLRMDDISINIKPLCVISNGNYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ41</accession>
    <name>L7JZ41_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0434"/>
    <dbReference type="HOGENOM" id="CLU_2967563_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ41"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6668" checksum="D6F3858D39C7226A" modified="2013-03-06" version="1" fragment="single">VITEYVESNESVETVTMTIPPVVKTETISEHDKTKTATESASTETSKPKEENQEHFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ54</accession>
    <name>L7JZ54_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993886">
        <property type="protein sequence ID" value="ELQ76047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0981"/>
    <dbReference type="HOGENOM" id="CLU_2887425_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ54"/>
    <dbReference type="OrthoDB" id="2188726at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7882" checksum="BD0BD27CE61A2D0B" modified="2013-03-06" version="1">MAKNINCKKSWHPTRFEIQSKIHEYKMKEDEKEKRKQLIASELEEEERCFGEVRRMKWMEENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZE1</accession>
    <name>L7JZE1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab GTPase interacting factor, Golgi membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZE1"/>
    <dbReference type="FunCoup" id="L7JZE1">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0182"/>
    <dbReference type="HOGENOM" id="CLU_074741_4_1_1"/>
    <dbReference type="InParanoid" id="L7JZE1"/>
    <dbReference type="OMA" id="HIRAKSM"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="189" mass="21040" checksum="81B17F689D7CAC3F" modified="2013-03-06" version="1">MDVRPTIDLKSAFTGYEPGDPPLLQELGIRFTTIHQECALIFHTPTKSANIDKVDLTGPLLLIFLFSSILLLTGKVLFGYVYFMCVLCTFVAHFVLNAMGENEIEYVVVCSVMGYAMLPVVCFAVVHVLMCYLDVNVRVSLVCGGIGAFYSAMVASEVFVAYLRLKSVRVLVIYPMFLVYMSFVVLALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZK7</accession>
    <name>L7JZK7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZK7"/>
    <dbReference type="FunCoup" id="L7JZK7">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0859"/>
    <dbReference type="HOGENOM" id="CLU_030733_4_0_1"/>
    <dbReference type="InParanoid" id="L7JZK7"/>
    <dbReference type="OMA" id="RFANCAV"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="283" mass="33254" checksum="9F4DBC9ABA78DC68" modified="2013-03-06" version="1">MGNDPADSFLDEKNKFRYSPAYTALSVFLGDINENIRERSYKQDPQNFVILLLNKIDDKIQNTPLNTGPQRFANCAVAEVYEFIESVPLDFGEFTKVSEDDRHILHVYLDQSFGSKHRFDYGTGHELFFLSFLYVCNQLGILSIYDMEEVFQRYFQVVRNLIYRFNLEPAGSHGPWVIDDYHFMPFLFGSAQLIDTKLTFTDLFKKENAHLLYSEAVLFCIKHKCRFVKTDFKKHSAALYSIKDIDWKSINERIMEMIEEEVMGRDVVTQHFIYSKYLKALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZN8</accession>
    <name>L7JZN8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0100"/>
    <dbReference type="HOGENOM" id="CLU_1870146_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZN8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="137" mass="14854" checksum="904FB09F918409A4" modified="2013-03-06" version="1" fragment="single">VLCWPSMLSKAAKKLGVILFTLFICIVGVCIIIYCLNGRSTGNRNENTADGAHKGSAWKASKDGQNDTSGMSNTGFAAKRNANRNDKQSKVNNKLEGGRPQNAGFLGYVAKTSMAFYHTISAAISNFFSYIGSFWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZP1</accession>
    <name>L7JZP1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA nucleotidyltransferase/poly(A) polymerase</fullName>
            <ecNumber evidence="7">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="7"/>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZP1"/>
    <dbReference type="STRING" id="72359.L7JZP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0214"/>
    <dbReference type="HOGENOM" id="CLU_395476_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZP1"/>
    <dbReference type="OMA" id="HLETAVM"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="639" mass="73994" checksum="AB5F7623159CB94B" modified="2013-03-06" version="1">MSLHEIRLTPTEEKILTKIKTYAHTLQGIVPRIAGGWVRDKLLGKLSNDIDITINRISGYAFASGMQKYYGMTGSVGQIKANPEKSKHLETAVMRIEGVFVDFLSLRTEEYFDTRIPVVKSCSAQEDAFRRDLTINSLFYNIVEQRVEDFTGKGLSDLEQGVIRTPMEPLKTLIDDPLRILRVIRFSVRFRFKIADDLFMAFQNEHVRTNLHKKISNERIGQEMYKILGYEHFIHAFKVITQCELVPAIFKKHIPIDQHILMHGYDNYMRLQKYFVFDERIARLYIILLHNACVSVENTFSNFLIVKNYLCYGKKDFTRVKVIEKNLCLLRKVNERMSAEDAVFLVRHMKEEYELSFFVYLMVADYEHDDLERNFYGIIDESVGDEEERGVNNCEIIDKTEKNTKNEQPLTIEKRRTEQSDEIIANREYVKGNQTTEYGEKTFSCKHESKETIGKCEYSSDARAEGSLTMEMMNLHIPGNSTSDARAEGSLTTEMMNLHIHTSNDMKAADLSYSDHSSMNADNDTTRAHPLPADRSSAGTAHESLKQCANKNKHLILHILRTIRPYKTRLFSTTFTFNGRTIFDTLGIDQNETSFYLEMAKVQQIVHGVADDDIMDRMKVIKEQQRIKGFRAFYLTNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZW2</accession>
    <name>L7JZW2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0137"/>
    <dbReference type="HOGENOM" id="CLU_1964913_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZW2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="128" mass="13649" checksum="CD8B9FF0B262F1D6" modified="2013-03-06" version="1" fragment="single">VLRFLKKELVSVRDVDGDVLMCSGNRIMSVVSFLCSCVDARVAAVFARRIICDYEGCGGVENNCGGVENSCGGVENSCDGEGSGKEDLKEGPKEDDKGSLDESLKEGLNESPNESPKEGLKESVKEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K009</accession>
    <name>L7K009_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K009"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0669"/>
    <dbReference type="HOGENOM" id="CLU_1240897_0_0_1"/>
    <dbReference type="InParanoid" id="L7K009"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="223" mass="26724" checksum="BB0A6BF2A33D128B" modified="2013-03-06" version="1">MYVKIRKQKQVYKSATAAINALQSIINKKNLFIVHEKTKHAFMELKRKYTKRDLRSKILNKLQVCIKVFANVRLSYIRYNQAFVLLYWITLYMELLSGFMCVILVQEDLKYLLEQLEDNVECYSVLINEIIGRPYEAHHRGEWCLVDRDMFNDLIFIVTEFITEYKSENVFWLEQGVVVGKYAHVYDSWFLESWFPFTVDDLNQWTDTMDNRFGIYKFAEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7K023</accession>
    <name>L7K023_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Farnesyl cysteine-carboxyl methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K023"/>
    <dbReference type="FunCoup" id="L7K023">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0048"/>
    <dbReference type="HOGENOM" id="CLU_1435449_0_0_1"/>
    <dbReference type="InParanoid" id="L7K023"/>
    <dbReference type="OMA" id="RYNTPCT"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="190" mass="21867" checksum="252FD5EA91E093D7" modified="2013-03-06" version="1">MTSTSCSYFLLGSLHVLLLRYNTPCTTVFSLYALLLFLYIYTTNTLKLEMHIKENDLFYFVFSQALEHYFMQSYLRYRIFSIFGGLTTIAGATAFIYSLLSCKMSNTTTPFTGLFSVVRHPLHSSLFIFLVGSCVYLSSFVSLAVLVWYIRTNVSSFAVLDEVYKDHEEYLRNVPSGIPFMITEVKKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K037</accession>
    <name>L7K037_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K037"/>
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    <dbReference type="HOGENOM" id="CLU_1850028_0_0_1"/>
    <dbReference type="InParanoid" id="L7K037"/>
    <dbReference type="OrthoDB" id="2189578at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="139" mass="16704" checksum="463D705F1F48583C" modified="2013-03-06" version="1" fragment="single">VVDSNKETVNVDVNMINEYVNMLYSVKKELMNSPFIKYKDVVKNFNKNYLSKHQSYLLYKNMKKRQILLDKLYSTDNTVLKCFFVELLQNKVVYLSEMETKYKLERVNMFKIVYNLISRGMIDFDKNNECIRLGLNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7K076</accession>
    <name>L7K076_TRAHO</name>
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        <submittedName>
            <fullName evidence="3">Putative CAP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ76492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K076"/>
    <dbReference type="STRING" id="72359.L7K076"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0520"/>
    <dbReference type="HOGENOM" id="CLU_305694_0_0_1"/>
    <dbReference type="InParanoid" id="L7K076"/>
    <dbReference type="OMA" id="NTEEFNG"/>
    <dbReference type="OrthoDB" id="568194at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05379">
        <property type="entry name" value="CAP_bacterial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31157">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31157:SF1">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="899"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
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        <location>
            <begin position="605"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="661"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
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            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="970" mass="107846" checksum="45FE08BECECC3833" modified="2013-03-06" version="1">MLPLITIAVHTLTIYTSLLTITNEYRAQNALAPLAVHPSLTRAASQQANTMCTRKSLVHNNLSGRLAAVDFVGARIGENIARSVENDEHRVFEVWLKSEMHRDNIVGDYEFVGEGKCVDGDGYFYYVEIFGRRARDTDGKDCGDGTSCGEIGARTGISAVKYDVPEQHGNTVKYDDGNTKTKRTIRLIIDRSSSNDNHPKNDPNTPNTIGYISSYGANTGYNTNTISYSDFLVYYDQFLKNYLSSLQTKDECTIKEINEKLKSIDGQLSRLLGRGNEREVNGGNDKCSGSCGVRGGGYEPVYDDNVKNVSDDKEGDKSRDNGRNENDDNVKNVNDQNVKNVNDDKEGDKSRDNGKKENNDNAKNVNDTDINKINDKPENDNNSTSKNINKVNNRSENENKNGNKNTADEGDSNTSSPEKPKNDVRVPIVVSDKKNEKRRNVLLINLKDLLGNIPNTSIIDENTNNDKGNGEMATNTQQNKGPDNRNDDENGGNANDKGENGGNNTKNSTKSKDDQNASAKNENNGEINMGSDVKGLAEILEHLKIGKKTENSNVDPENGKESAGQSNDKHEMDDDLRFVIKIGNNGIENENEINKLISVLKKIAEGKDTPTNEGGDKNKQGELERQNEDGKNKQEELEGQNGDGKRKTEEKDNGDKNKQEELEGQNGDGKKKPEQNEDGKNKQEESDKQNGDGKRKTEEKDNGDKNKQKQAEKQNKENENDETGKELILKELISLIGKLERIRTGESAKDLKKEEQSENKPEILNWVKGLKSIIEKYNEESGDKAKNGHENERERIDDRNKNGKMSKDGDTSKDNQSKRSDKDKNDGEKTMSNSPDDSDKNKNSSMNRKETVSNSPDDGKKTKDGDETNDQNGDGNKNAARNSTGNSRPANTVKIRKRYNPFSLNQTKITTKLAELCRLLSASDKMNSFNYTNMSKLCTENENGLDDEVYGSNDQIEIGVPLYYGAQLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0C2</accession>
    <name>L7K0C2_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0C2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0307"/>
    <dbReference type="HOGENOM" id="CLU_1846500_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0C2"/>
    <dbReference type="OrthoDB" id="10681255at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="139" mass="16545" checksum="213C0EF5E5BD1A95" modified="2013-03-06" version="1">MYCSFFAYLVLIRKLEFQIHKIDEIKGCNDNSPKIVLFNKYLLKHRQKMVKKIKRKIIQLFTELKKRNDDPETVLEHFNEDLKNVEDVVASISLRKRLSPKIMALFSEQENYGTCLDLQFLTAYYALSYDENPSKNNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi incertae sedis</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="InParanoid" id="L7K0F2"/>
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        <source>
            <dbReference type="EMBL" id="ELQ76981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="47" mass="5634" checksum="32D8FD96ABB91656" modified="2013-03-06" version="1">MVSAEHIWIVHLGVLMKVYLSINQIHRLKNENDWLIQRVIIIKMHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0F7</accession>
    <name>L7K0F7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
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            <taxon>Fungi</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0376"/>
    <dbReference type="HOGENOM" id="CLU_2559916_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0F7"/>
    <dbReference type="OrthoDB" id="10518826at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="82" mass="9342" checksum="EF772BCF91B1ED99" modified="2013-03-06" version="1">MILPFIFTFLGSLMITCGLEVLYNFEWNFLEVICSSYQCLDANMNKEASMVAYLVTLFSFALGFGIQIPTILKLHKKKPPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0I8</accession>
    <name>L7K0I8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0I8"/>
    <dbReference type="STRING" id="72359.L7K0I8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0196"/>
    <dbReference type="HOGENOM" id="CLU_1647841_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0I8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="19340" checksum="29016AFA85C61BAB" modified="2013-03-06" version="1" fragment="single">VDDRKEVLDFLSALLDFSSIPVTKNDVDEVSIFKKTSFVKMAVNNTYLAIKKNKYDHRDFTIIENKLRKVNLFNKFTPHDELATLEKKLEEIEDKRVRNQSVYKEKLENVEKLKSCFQKIQATRDEEKRKIYEYERKVAHRERLIDEIKDLEIQLERSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0J1</accession>
    <name>L7K0J1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0J1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0176"/>
    <dbReference type="HOGENOM" id="CLU_2711825_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0J1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="8585" checksum="4E9A4D4D95A29CCE" modified="2013-03-06" version="1" fragment="single">VFIVILEQGSLMNISKAKEELKKKKERYGELEMPETGTIINYLNECECPEMIRIPKSFVDNEKEDYKIMGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0L2</accession>
    <name>L7K0L2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0L2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0066"/>
    <dbReference type="HOGENOM" id="CLU_2639853_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0L2"/>
    <dbReference type="OrthoDB" id="10384884at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036785">
        <property type="entry name" value="YkyA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140423">
        <property type="entry name" value="MW0975(SA0943)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="77" mass="8805" checksum="CF1EAE58D51D56B1" modified="2013-03-06" version="1">MEQPTQLSEIMNVIKTQKKICEIAENLYECLQGDEVDVDQASGQIDALESACKEHEQQFERCARECGEERDIEGKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQV0</accession>
    <name>L7JQV0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQV0"/>
    <dbReference type="STRING" id="72359.L7JQV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3213"/>
    <dbReference type="HOGENOM" id="CLU_1611961_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQV0"/>
    <dbReference type="OMA" id="LKNEYVM"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ73838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="165" mass="18764" checksum="EE415372E811B1FB" modified="2013-03-06" version="1">MVQGEINEAAHKECTSYVDAFKDVIKSSEDVRTFVDISNMGMPPAGKEHIKRRVSCNFERFKGNYLIISFVFIAVFLIRQLSALFVLALWAGYFFAADCFGDKFAVGGYELKNEYVMYFCIVLTVLYLIVFNTIIVSLMVTLSLFMVVVVAHMLCYKDEPSLEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQV4</accession>
    <name>L7JQV4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994104">
        <property type="protein sequence ID" value="ELQ73814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3276"/>
    <dbReference type="HOGENOM" id="CLU_2177194_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQV4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="13556" checksum="E0A94A6E327ABE50" modified="2013-03-06" version="1" fragment="single">VSKMKLQQNKLESDYLHTNLCIEYDKILYNLCRLVEFLQILLSPEKIRLMFKKLNTKISLPHVLNNEFMIRLYRMFCENKLYPFGMDELRRLTCVRERFVFENENEENQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR07</accession>
    <name>L7JR07_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR07"/>
    <dbReference type="STRING" id="72359.L7JR07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3186"/>
    <dbReference type="HOGENOM" id="CLU_415099_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR07"/>
    <dbReference type="OMA" id="HERFIMI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="769" mass="88167" checksum="93435106D0720B12" modified="2013-03-06" version="1">MENFGIDIGDHKTVLTGSSRNGRILIDELNKRTIQTQFQLSHPQRKFGNNVGGFKQQDMVERYRHFTNDQKLLTMYFCYLHRLILQNMDKQPVGFRPNVTISTRCTSLKAIDDVLMCARAADLNVVGVYDDLTCAAAHLSLKVKAHERFIMIDLGHAHSAIGSFTFVDGKMRARKIEQIEIGGGSFDERLFYHILEQCGLEKEQAKGDSGELRTSEKEQAKGDSGELRTLEKESVKSNGMYRGITVNRTNYRPCTYKETYKYLVLRETVIPKLKKYKMILSSTAVLEDTLEVGDDLYKIRINQDEYRAMIKDDIDRIGAFLRERIDEYIKDENHFCDYEGAIVEVVGGNSNNSFVREMLEQLRVKVRRSSDSHESVGFGAAIAGALPFYTTAMRVMDVLVGDVMLNGAVIFRDGALMEESVVVDRDGERVFWRLSRDAHEQDVAVEALEGSSSRDSSCDAHERNTRLSDQAPGGSSCSSRDAHEKNARSSVQAPTGSTLTFTHQGDVLLDEEIDTPFTAVLTRNKQLQIKGHNFETDCSHLLKLEEEFRQREIEIEQIGNLTNEYQLYLERLQNTMSKPIYYTLFTEDDLNNVCNLSMEFMYLPVCDTLKDEKKKIDEYNSKIDKFVTRMKDLMECKKKAVHDRIELSLKNLKGVKTCTPAVYKLQSRLNGNKDLLSRCTFDGDVEILNLERLDEEIVRMELEIEREVKEKEREKAEREEREKVAREKLRKAKEEKKGDDMTGNEADENKDEEQPLERNEKAKADEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR82</accession>
    <name>L7JR82_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor 4F, ribosome/mRNA-bridging subunit (EIF-4G)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_3145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR82"/>
    <dbReference type="STRING" id="72359.L7JR82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3145"/>
    <dbReference type="HOGENOM" id="CLU_362557_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR82"/>
    <dbReference type="OMA" id="NRIAWTN"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="6">
        <location>
            <begin position="435"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ73949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="859" mass="97468" checksum="B01DB39C3335FED2" modified="2013-03-06" version="1">MPFIIKRILFYPKKNLMEIGSPSIHRPYMHESGIPESEVVLFTENKARDLMAGGTKITKEMLDAIEFSSSSSEESTADNRDLGDGRAAVAENIDKIVADEFKAKLQKNEGESTEEASEESTKEPSHDNESLLSERLASTLRIAGETRVNEERLKIAIQKATKQIDNASKTVMVAEQEHLSVAVNSQTVTAAEQGQKEQRRAVEQPGAALPSQTVTATEQEQRRAVEQPGAALPSQTVTAAEQEQRRAIDQPREQPNTAMPAKTNEHEIRAQPAVAEPGITPAPVESLAEIADTTATLDIPQDDAAEKIYVYQPSAQQSLPAKVLLERIKTNFHVCFLDLHDEAVTLNENFRKEFYGKFMKILEDEIGQKDVGEKYIKSLQDIRKSLKSKYDNVVRKDVDVRYTVEEILAIKERAEVPINVDKTIFATVPRRERREDAISLFRLELNRIAWTNCNSTIERIKRLKVRRDDEIKKMAEILFEKAISEEAFCKLYAFVVQNLYKTFRSDEERRRSDTKSVFFTTLIKLCQNILHSKEKWSKAHDLSTLSMEERITMEETLENENIEKEVKKGRMLGTVKFISLLYSYTIIGFKGISACISSLLDLDDEQNVETLCALLSNCGEKMVQSGKHAELINVMNMLRQKRQWSNRIRFMVCDILEKCDGWIKEKRKDSPFKNSFAALKNDRGFVMDKENVEIAGKESRPAVEHGTVPAQQAPAGNSKQRESLLLDTIDVMSRIIEDVPHVNDYTALVNEMKERTKTVDLSIVLESYFLAIIEIYESYGDYLKLLRLYLTDVKADERIINESVVNVENKLGDISVDCPYAKSNFHLLAYSLGRWAGCPVKVGGYDEEGVKKKYESLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRY9</accession>
    <name>L7JRY9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA helicase PIF1/RRM3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRY9"/>
    <dbReference type="STRING" id="72359.L7JRY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3291"/>
    <dbReference type="HOGENOM" id="CLU_1696019_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRY9"/>
    <dbReference type="OMA" id="RERCFAK"/>
    <dbReference type="OrthoDB" id="2272314at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="158" mass="18222" checksum="0D9A6CAFBFB35C87" modified="2013-03-06" version="1">MRDVNPYAEAFKNLAEVERNALQEGTTLMDLNMVFNANIHRNMNRYNVPRASEIAMIFNDRNGEPPFARDVKVYARNANYDNITLSILSPHLDPMTYALLYPYGEPGWTRDLVSQGNNVRCRISMLQFKVAQLAIRQNVFNPHLHAGKLLQQWIVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRZ3</accession>
    <name>L7JRZ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RAB proteins geranylgeranyltransferase component A (RAB escort protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRZ3"/>
    <dbReference type="STRING" id="72359.L7JRZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3256"/>
    <dbReference type="HOGENOM" id="CLU_765103_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRZ3"/>
    <dbReference type="OMA" id="AICECND"/>
    <dbReference type="OrthoDB" id="2195620at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="39211" checksum="CBCD4AD0842B6425" modified="2013-03-06" version="1">MDFEYGYEGTSAKDLIKLFDIRKKDTIVYDNSDFYGTTSTPLDLPTSKYVKDVQTIKMTEPKCLIETEPQLFRTNGRLLSKLEELDLLLNIDFIEIYDHLYIDENLCIYKVPYFDYEIANSNWLEAQEKNAYFYFVHNGIKYEDFIASMSKRSLQIFNSSLNILTYENCIPNYLSSFGTPPFSYPMYGEREISDQLSRVLSFRNISFYVNKSLKCTRVNDHYEINGIYGNATFRKRKSEANEVVSPVSFYFRVLLLKQPFILPTFFGTIMVDKKIVNVISINCSAKVCPPNTFLVYFYADHKLPAHLMSHLKIDENNILNDVTFSNMREFNWSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS04</accession>
    <name>L7JS04_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCAAT-binding factor, subunit A (HAP3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS04"/>
    <dbReference type="FunCoup" id="L7JS04">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2897"/>
    <dbReference type="HOGENOM" id="CLU_066247_12_1_1"/>
    <dbReference type="InParanoid" id="L7JS04"/>
    <dbReference type="OMA" id="MQTDDAN"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="163" mass="19026" checksum="C2AEBF5AE509D644" modified="2013-03-06" version="1" fragment="single">VMAETNQFYMSETNQDTTRPSKYKRLQFRSDMDIDKNSYGPLKSTDRLLPIANISKIMKGPIPRSAKIAKDAKELMQKSASEFIAIVTCMAKEICESENRKTITGDDLIRSMKQLGMYYYAEITKKYFMRYKDGGKAFKNKSYTEKDFGEHRPHFSNDYRHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS23</accession>
    <name>L7JS23_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS23"/>
    <dbReference type="STRING" id="72359.L7JS23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2807"/>
    <dbReference type="HOGENOM" id="CLU_1385052_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS23"/>
    <dbReference type="OMA" id="PINLCTF"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="22616" checksum="B24429FC375B84FC" modified="2013-03-06" version="1">MSISSFFIVNKSGGMIYKFLKQEEGITKDNSTNRNDKSNENITDESKHLKVTSSENNIDKTITNKTEQNKDELKRTNKKANANSHTQRASNQNAGVQLCTTNLNNLLVLNSTLHTIHQMASTIYGQSQKFYIYFTGLTLTMFKTMTGYTFIFVGDEKASDKLVYDVYKEFNLYVLRNPAYMDDMPINLCTFKPNKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS39</accession>
    <name>L7JS39_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994059">
        <property type="protein sequence ID" value="ELQ74224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2856"/>
    <dbReference type="HOGENOM" id="CLU_3175707_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS39"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="47" mass="5587" checksum="AD8E1787711BE329" modified="2013-03-06" version="1">MNIVIREIKWKAFNDEHKMKLFLALKFMSEVIKMLLVKSTLISIATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS44</accession>
    <name>L7JS44_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994075">
        <property type="protein sequence ID" value="ELQ74110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2973"/>
    <dbReference type="HOGENOM" id="CLU_326429_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS44"/>
    <dbReference type="OMA" id="DISEYEC"/>
    <dbReference type="OrthoDB" id="10348791at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="883" mass="103013" checksum="C70F07C0E3BC95D5" modified="2013-03-06" version="1" fragment="single">VILLSPLLFLLLSPLLSPLLSPLLSPLLFLLLSPLLSPLLSPLLFLLLSPLLFPLYFPCRYSSISSFFTLLLVTPSMKEYDFNRKYGTEEERLKAFEYLLTVSKQLIKRKERQSTSYFVRNIDLVFKILPTNCALLFPLLLVENVEIDNAFSRRFGTFMHTYRDNPHAYAKILHHWVTKYPDVVVYNIRGSVFNLFLDNLHVENAANTFVKFYDMREKEFDVFLALMKKYRFFTRLLVLLEQTVGRDISEYECSSEYNYENIRVRFSDRLDDLRNEVTKNDKNKKKEESVRYVRKESKTNDGLEGVIQEFKKLRISDEDKCMDKDARANEKGVRVQNERSGDEKDLRPQSARSGDEEGPHPQTARSSDEEGPRPQNADNDKSMNRTNMQIRRNVLAIILSFLRKYSDDSINHKIMKQSNVILNLFLEENVHIIELNSLFNILKTLVSKRNCKVLVDMMGRRMNTFRFLFNTLGDVCIKETTKGSADKGTGNDGGKHASNQEEDVSNDDSDDSKVVPIDFIFNNTNFIPNLEIDYLNGDKMHKKRGHYKRSVERQLVKLKESALDLHLSLKLNLLCYCSKYRKIREIIRKQLLHIYFISVFFETTNTFVLHSFTVFLENCLQDYRFMAEILLSTNLLKMIQRTGKLQYMNLYERYPERKPMFVFNSYVAFLLMKLKQDIAAYCRVDLKVMENRNYSDYDWRGEDRVYTDYRNVIFRRVIDADVEQASFERNGAYGRGSAGTFDNADSISQSSDGYIAHDGDNEYVRGDGGINISGRATNDDTRSSAARDSPSTRDKKTIANMSTSKADIINRLLFKLRYLESDDWLFVQDGVFTPEIARYKVSYDDKSVHDYMENNMPESMYRFLFKNLVWDMPFCDIFSENGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS55</accession>
    <name>L7JS55_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2821"/>
    <dbReference type="HOGENOM" id="CLU_2656208_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS55"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="9051" checksum="45A6CA4DC30BA176" modified="2013-03-06" version="1">MSFIYLGEHEICPGENTRNKYRERRKYNTYQEQGSKNMPKNDHPLGRNEMDCVVALSLLKKGVKHVSIDVYNRFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS87</accession>
    <name>L7JS87_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_3189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS87"/>
    <dbReference type="STRING" id="72359.L7JS87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3189"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="InParanoid" id="L7JS87"/>
    <dbReference type="OMA" id="SHYDINH"/>
    <dbReference type="OrthoDB" id="2192794at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="63"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ73911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="333" mass="37290" checksum="1399C347AD9F03EB" modified="2013-03-06" version="1">MQPSAANGREHYVDSCTNDPSSVADVVNTNVTDHKVLGFNFSSNKSTPTYTEILNNLVNFKLPDVNHALRILDDTKKLLMAEQNLLYIESPCTVVGDIHGQFVDLLLFATDDKKFVFLGDYVDRGTSSVEVILFLCLKKILHGNVYLLKGNHEMANQNETYGFKSECLLKYDISFYRKVNEVFEVMSIAAVVDRTYFLVHGGISPHIGNIADIMYLDRTDFGSFLPLLWSDPQEENGYKTSPRGAGYLFGPDVLNKFLDDNQLSYVVRSHQLVMEGYKIMGRCIFVWSAPNYCNAMGNAASIMNINGQGFDFFTFTAASKNKSTTFGQDGAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSA4</accession>
    <name>L7JSA4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994048">
        <property type="protein sequence ID" value="ELQ74304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2775"/>
    <dbReference type="HOGENOM" id="CLU_1830076_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSA4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="141" mass="16074" checksum="CAF5885546A71683" modified="2013-03-06" version="1" fragment="single">MTLEDVTLSNGCIMLLHKHITKVELERFTGLIRISNIVRNESCVSYLDSGTCQLQRTDEGSVQELTLFNANLISTTTTTEHQIDLNDGLNLELSNSIKKICLKNCCGVLLFEDWPIFRKIVFEQDNRCPISGQMFQFVRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSC7</accession>
    <name>L7JSC7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2898"/>
    <dbReference type="HOGENOM" id="CLU_3263274_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSC7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4823" checksum="36CFEB91158773F6" modified="2013-03-06" version="1" fragment="single">VRKVESSGKDDMGSIVFYGFVGLWSSDELLRWVSIDQKNIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSD5</accession>
    <name>L7JSD5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
            <ecNumber evidence="8">2.3.1.23</ecNumber>
            <ecNumber evidence="8">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.23" evidence="8"/>
    <dbReference type="EC" id="2.3.1.51" evidence="8"/>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSD5"/>
    <dbReference type="FunCoup" id="L7JSD5">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3106"/>
    <dbReference type="HOGENOM" id="CLU_052673_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSD5"/>
    <dbReference type="OMA" id="NAWVSRY"/>
    <dbReference type="OrthoDB" id="2189411at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ73966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="411" mass="48225" checksum="E880A5D56EA35ADF" modified="2013-03-06" version="1">MNIMTLERELRYGTAILFQIFFSYAFRGVQKYNFVLSSLILLIAFGVKSYAVCMAFLLFNTSTLLSTIRQKHKRVIILVLNLFVLQYVYHLFDDEISICSPIMMFSVKFFFLVAEIDWNTDSVGDVVAYLFSIPCILVGPAISFVDYKNLQKNAKQRVMKETEGGKPPRKHPNDLIHCLKNVLYEQNGVIQGVYLCLQAVFYLWVYLLLSKHFVVYDVINKKAYWRVFYMYIAHFCFKSKFYFVWTVSQLCNHLYGCTNLKNISKTGVELAQDFKELTDSWNIYVNRWLKVAIFRPLKPYGYFFACFMTFLYSSLWHGTSICYFTLFMSVPLIMKPMKSAKTFLYLCFPPRVAKVLNHLLFRFVLAYYGAPFMTLDMSKTFEIWNKLYFSGHLLIIPFLFIGNSKNIKPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSF8</accession>
    <name>L7JSF8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2651"/>
    <dbReference type="HOGENOM" id="CLU_2238496_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSF8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="105" mass="12128" checksum="B6E355AA27CB56F0" modified="2013-03-06" version="1">MFTLRITFDQFLLVSLGKDNKFTDVFKVSDYELGPEGFFAISVDNSTGYSDFKLQAIRHSTIEYPIFKDPEEKRSSGGKWIWLLFLIVVAFIAFVLYKKQVTKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSG5</accession>
    <name>L7JSG5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSG5"/>
    <dbReference type="STRING" id="72359.L7JSG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2662"/>
    <dbReference type="HOGENOM" id="CLU_134505_2_1_1"/>
    <dbReference type="InParanoid" id="L7JSG5"/>
    <dbReference type="OMA" id="YYGQDLA"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="10036" checksum="2F76477BF6494741" modified="2013-03-06" version="1">MFKNLYKTLTQPIDYYGQDLAKKAAYNILLLGYSLAWIVGYFMSDLRYTFITGIVTVLIAFIVVVPPWPFYRRNPFKFKKLKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSK8</accession>
    <name>L7JSK8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein RPL1/RPL2/RL4L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSK8"/>
    <dbReference type="FunCoup" id="L7JSK8">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2647"/>
    <dbReference type="HOGENOM" id="CLU_026535_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSK8"/>
    <dbReference type="OMA" id="ALYGTWR"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="325" mass="36026" checksum="365940369DDC24AB" modified="2013-03-06" version="1">MQKKVEIISKSSTPSVVDLPPVFRTPVRSDLISFVHKNVALNKRQPYAVSPNAGKNYSAEGWGTGRAVARVPRIKGSGTRRAGQGAFANFCRGGHMAHPTSVMRRWQRKTPLSIRRLVTAMGISASALAPIVESRGHRISGLKSIPLVIDNEMLQGIEKTKDAVRFLNELGLSEEMDKTKEVFIKSGKGKMRNRRYKVKKGPLIVYDGEICAKAFRNVQGVDMCQVDSLSVLELCPGGQPGRLVIWMKDAFLKLHDLFGDFENEANLKPGFLLTGGIASNDDVEKIFYSCEVQAFIDEPCLVDKPKLVKNVQEIEKLNPYLSLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSQ1</accession>
    <name>L7JSQ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2768"/>
    <dbReference type="HOGENOM" id="CLU_1763301_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSQ1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="16832" checksum="416032C37AFBBF8E" modified="2013-03-06" version="1" fragment="single">VYCTKSALTLESRCPMMKPTLEQILEKKAQLRKVECRSKPKQEKYAGRNNGKFVDAVKKLKHVEKVKETVLSIRKPNNYTFNTCMSNATGIPSECLRQIDPEPKNKIINYDVEPVRKGIIKNKTVPSVIDSEAHAIENNKTSTDLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JST1</accession>
    <name>L7JST1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromatin remodeling protein HARP/SMARCAL1, DEAD-box superfamily</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JH994106">
        <property type="protein sequence ID" value="ELQ73797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JST1"/>
    <dbReference type="STRING" id="72359.L7JST1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3292"/>
    <dbReference type="HOGENOM" id="CLU_881564_0_0_1"/>
    <dbReference type="InParanoid" id="L7JST1"/>
    <dbReference type="OrthoDB" id="2194725at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="316" mass="35411" checksum="6CD63DFE5925207A" modified="2013-03-06" version="1" fragment="single">VLEGFNYNDYVNRYCMDGRSRFNKFMKYKGCSNYDELSLVIGGMMVRRTKDDVMSDLPRKYRKHVLLGCMGGCSSVRTTGTMRRINSDDSGNTGRMGLINNFNARDTANTPNITPLDDVDHTIMEMYAQAAEIKLSSVVSYVREYINQHIKDKKNKLVIFCHHKCMITGIINALDVGYIKIDGSVNSSIRQRLVNSFQLDDNIKVAMLSITSANTGLNLTAADTVIFSELYWNPGNLLQAEDRVHRIGQRKDVEVYFLLGKGTIDEMVWPKIVGKLGVLERLGVGENVLKSVGERKGGNILSVFERIKDGKASGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSU0</accession>
    <name>L7JSU0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3286"/>
    <dbReference type="HOGENOM" id="CLU_099520_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSU0"/>
    <dbReference type="OMA" id="MHRFALM"/>
    <dbReference type="OrthoDB" id="2193035at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013107786" description="GOLD domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25306" checksum="C61CC6A856F4C152" modified="2013-03-06" version="1">MIFFLLLPIQALIRTITNNRPLVQFKQLAERTVVLMEVSIMYRANEFAPWQKLDQNTPIKTDLLITCSPDRDWTTMNKNPQFVAEYTGTGTKPTFFFTSQVNTMHRFALMLPVPNVGMYGAEMKLYEGRAKNPNVISQTDSTLRELERQIRYAIGACQEIENVMRMDLMDEGEYDGIMASTARLILGSILFKIVVVMVTFVYFNKKLKQFYVTKKIAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSX3</accession>
    <name>L7JSX3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uridylate kinase/adenylate kinase</fullName>
            <ecNumber evidence="5">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="5"/>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSX3"/>
    <dbReference type="FunCoup" id="L7JSX3">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2554"/>
    <dbReference type="HOGENOM" id="CLU_032354_4_2_1"/>
    <dbReference type="InParanoid" id="L7JSX3"/>
    <dbReference type="OMA" id="HSENANC"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="125" mass="14246" checksum="F3F6D7308FF112B1" modified="2013-03-06" version="1">MGSGCLVPDDLIIEMMHLKLSGSGSYILDGYPRTMKQAQLMKEVDAALFISVDEDECVRRIVGRNQGRSDDNKETAMMRYRIYQKETLPVVEYLRDRKVLSEIDGNRSVEAIYGDIRKALDGLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSX5</accession>
    <name>L7JSX5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2491"/>
    <dbReference type="HOGENOM" id="CLU_445642_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSX5"/>
    <dbReference type="OMA" id="QCCEISI"/>
    <dbReference type="OrthoDB" id="10327899at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="613" mass="71229" checksum="CF14ADB9370C84E9" modified="2013-03-06" version="1">MGSLEITFNDLKIYCDATCTLSIKKLSISGQVIIKGASSLIKSILIDVLRTGKSKHDNIKVTGSLQMNNHKLSLDFLEKLIPSHIKCTYCYTTLSKLRFIYNFTKTHVKLQPERILKDLLLPDKCIAHLTTDELWAFSIACNIIHGHKIIVAANIKPTFFYLNAMDKMMYYTTLMPLVIIFDHSGEEMCLGSSFYLLKKINIMEYKLICLDHDSDSDEYTVIYMGKQIYDQVMEEKAAKCMDSNAFFENVLSDELKNPLIINERSKNKQLSMTKRTFNVNFYRIDFKTIRLINYLRFKEYLGNRCNLINQLVMLGILIMLFISKLFADEAQDEASRMACNLNFSLVKSFNWLKRFLIDRYSQCCEISIGSDKAERLRMLLRAKKLLRDISEGKRLVGSDLNDNCIERIAKSVDLLTIRMLCLTVKQAVTNMRLSTSLFRTCVKYVVNNHNAFELLIIGCFVSTNTLRLINQEVDFNYRNNNLIYTPCTYFLSIIKFLVCDVCHNLINIIILFNKGHLLLQILNFSFLCTFIAVTKYSIILLVIFNVIAFSTSFDSIDFLREYPILFFVRKINPFFISKEIFSPSQLSIWHSFWYLLRFYVVSFLIAIYKFSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSY8</accession>
    <name>L7JSY8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2457"/>
    <dbReference type="HOGENOM" id="CLU_3299685_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSY8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="4850" checksum="FD240C8458E66D2C" modified="2013-03-06" version="1">MVALLDYENVYKVVVWIIKHTFNMKINPFYIVTRKNLAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT59</accession>
    <name>L7JT59_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino Acid/Auxin Permease (AAAP) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT59"/>
    <dbReference type="STRING" id="72359.L7JT59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2432"/>
    <dbReference type="HOGENOM" id="CLU_049198_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT59"/>
    <dbReference type="OMA" id="IANTASC"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="4"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="402" mass="44029" checksum="ADD3298DA089A16A" modified="2013-03-06" version="1">MGKNVSAIQGSILMMNTMFGVGVLYLPLIYYSLGWVQGLVLFVMVASVTALTMYLLGVAAIESEDPHPTYYSVCSRSFRFMGPCADIAILLCCFFCCMAYLTFITNTVHFEIKEAVPKPVITVIAAFLVFMLAVQKDLSSLKIASFVSVASIVYLACFVVYVFVVNRENVTVLKFNKDYSTGVSGLLFALGCQQNMVAVYSQLKDGSRAGVLKVAIGATLMGGLLYMAIGLFGYFGFGEAATTNILRLLTDRDSDLCKMLLKRNSVNKYAIRACDWLFIVTLSCSFAFQSHPARVALNNILRKFVGVKKEVLASNKYRYIATGTYVALICIIACFQVDCDKIVAYIGATCNNAICYIMPALAFIGLVKRSTVLRPIAYAVVALGAIGMIYMVAMNIIKETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTB8</accession>
    <name>L7JTB8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTB8"/>
    <dbReference type="STRING" id="72359.L7JTB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2488"/>
    <dbReference type="HOGENOM" id="CLU_1278423_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTB8"/>
    <dbReference type="OMA" id="PCDECHN"/>
    <dbReference type="OrthoDB" id="10253329at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF53">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="155"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="216" mass="25242" checksum="C70A09E7F0E6BCE0" modified="2013-03-06" version="1">MNREIQQLNEPGFEIFEVDSPNVYASITNVNTGIIYMKSLTAQVVCKQCQRNFTINRSKQCQCKNDLIYEFTPIFYHNNYVGRLEMSSLVLICFETPETILSCLNCGSYYHTKEKNVEFSCFNCNTFTKYKLNKVWLKPSRKEQNKEFVPVKGTPLPNNGACKHYRKSFKWYRFPCCNKLFPCDECHNESVDHELKRASKMICGLCAEEQNIAKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTP5</accession>
    <name>L7JTP5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2660"/>
    <dbReference type="HOGENOM" id="CLU_2869243_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTP5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="64" mass="7663" checksum="ED2F12541E16BDDF" modified="2013-03-06" version="1">MTVITIPAKKHNAVKILLSFIYLVLVMRKEYDEERHERRPRLNKGGFHKRHHPTAMFTCWNSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTQ3</accession>
    <name>L7JTQ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain acyl-CoA synthetases (AMP-forming)</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTQ3"/>
    <dbReference type="FunCoup" id="L7JTQ3">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2271"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="InParanoid" id="L7JTQ3"/>
    <dbReference type="OMA" id="NRGELCV"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="642" mass="72783" checksum="025F2A77E38ADA6D" modified="2013-03-06" version="1">MAALEKKKFSMVYEDGVYRHAQYMENVYCTQNGAESLHQVFIKAVQDSPSSQFLGTIKDNRVEYITYLDGYNRVRKIYSFIKGMNLDEEEIIGIFSVNREEWIISEQAILMADATSCPLYSTLGVDSIKHIINETNMRIMFVSGEKAEYLYEKILSSDPNGLEVVISYDHISEKMVACFADLGISVYFFDEIYENSTEKDIKPSDLKAQNARDVGDGFYDSMKVLKKIRNESRSKPDDVVSICYTSGTCGKPKGAMLTNRNFVSSIAAFARGDDNGSVIEVNNSVVYISYLPLAHAMEKICVYVIISVCARIAFYGGNPKNLQQDIKIIRPSFLVGVPRVFNVFKEKIEEKVNERGCLTRFAFYMALKYKKWKQRSGSVSSYIVDRFIFKKIAAEFGGNIRFGLSGSAPLNPDVCSFLQSVFSMKLYEGYGQTEALAANILKPPQCHTYGTVGIPFPSNMVKLIPSDIPDQYEILLKGDNVFKGYYKNPEKTAEVLDSDGWLHTGDLGIVKEGLFYIVGRRKEIFKTSLGEYIVPEKLEGLYKKAPIDDILITGKTCGDYIVGIVVCTDNRISKDEIKEKIQEIGQNEYLKGKITKFEIPRDIHVVREEWTIDDGFITPTGKKRRAILEEHYKNEVESMYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTR5</accession>
    <name>L7JTR5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycolipid 2-alpha-mannosyltransferase (Alpha-1,2-mannosyltransferase)</fullName>
            <ecNumber evidence="5">2.4.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="5"/>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTR5"/>
    <dbReference type="FunCoup" id="L7JTR5">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2626"/>
    <dbReference type="HOGENOM" id="CLU_024327_4_0_1"/>
    <dbReference type="InParanoid" id="L7JTR5"/>
    <dbReference type="OMA" id="FMETIPT"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979018" evidence="4">
        <location>
            <begin position="17"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="321" mass="38617" checksum="20F3D13C72CD1803" modified="2013-03-06" version="1">MLCFLHFLSIFSKENAVILILCRNREADEISTTLKNFENVFNSTYKYPYLFLNDEDFTDEFMKKVKEVISTEAVFGKLESHEWGYPNWIDKEKAAANRKKLEKMGIIYADSESYRHMCRFFSGFFYRNKYIKKYDYYWRIEPGVKFFCKMNYDPFEFLKKKNLEYGFIINIREFMETIPTLWDATIEFITRHKDIIPNQNVLKEILDNNKNYNGCHFWSNFEIANLNFFRGELYQKYFDFLDQKGGFYYERWGDAPIHSLAASIFLGKRKIHFFEDIGYEHPPFQHCPRNPSRFPDCDCNSNNSIDDGPFSCLREFIKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTS5</accession>
    <name>L7JTS5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2190"/>
    <dbReference type="HOGENOM" id="CLU_3377390_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTS5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="34" mass="3858" checksum="C2B2BE70C833AAD5" modified="2013-03-06" version="1">MKVFLHEPTVVKTMVGAQRVMRGRLGVWVVLGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTT4</accession>
    <name>L7JTT4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vesicle trafficking protein Sec1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTT4"/>
    <dbReference type="FunCoup" id="L7JTT4">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2139"/>
    <dbReference type="HOGENOM" id="CLU_009210_1_1_1"/>
    <dbReference type="InParanoid" id="L7JTT4"/>
    <dbReference type="OMA" id="LNSACKM"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="500" mass="59660" checksum="DF9A51C8EA7F37A9" modified="2013-03-06" version="1">MNLKEMMREKIAKDVLRQSSEDEWHVFVYNKSTARILTHIFTKTQILSNEILSMQRLELNRDPIAYPAIYFVTYCKETYRAIKKDVKNKIYTKYYIIHTNEIKENEKIIGDNIFYKHVDINFVVMDERVFTCLDSVEDAMRSFSSILKLRFNMVNLRADTALFEQLRTNDSMCESRSEYYNSDLIILDRSFDMIVPLIHFFNFESLLYDLNLCQSTTDESPLYREIRYLHIADTNSVLNNKAQKLVEGMKKIDQKTDINEIHKLVLEAPENIKLKESVNRYINLAEDTLNLFEKEQLNYIATFEQNISTGYDNKGSRYQNGIKDVFSVLNQKIKRENKLRLVLLLLSTHYDFQANEVSKLKDKLMLTDQELKIFEKLKVMRKNFNKRKEYNSKFTYEISRYDPLLHDLLRAFVQNKNNRFSNLVKRETTEKKESLRKSSFVFMRHETKKKTLVLYIDVLTYPEMMLINQMSEKSSYEVFVCTNQVVTPKEYLKWLEETRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTW3</accession>
    <name>L7JTW3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">20S proteasome, regulatory subunit alpha type PSMA2/PRE8</fullName>
            <ecNumber evidence="2">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="2"/>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTW3"/>
    <dbReference type="FunCoup" id="L7JTW3">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2343"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="InParanoid" id="L7JTW3"/>
    <dbReference type="OMA" id="WKACANG"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="230" mass="25433" checksum="F645303A099256A3" modified="2013-03-06" version="1">MEFNFEHTTTVFSSEGKLQHCDKALLAALKGNLSIGLNAADGCVLASLKPSDRLIDKSKVTKIVPLSSNLGITYSGLQPDFRVLTNKLLKMVEGYNMVYGKMYVDTLVNKISREIQEFTQLGNMRPLGLLLLVCGTTFDNKTKLFSLDPSGSFQEVACAGIGKNYSESIRYMERRSEGFEDNLSTAVCTLKEFAGYDLGPEEVQVGVLKDGSFRVLNDDEVKDIFDNINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTW6</accession>
    <name>L7JTW6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Suppressor of G2 allele of skp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994014">
        <property type="protein sequence ID" value="ELQ74864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTW6"/>
    <dbReference type="STRING" id="72359.L7JTW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2203"/>
    <dbReference type="HOGENOM" id="CLU_1972131_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTW6"/>
    <dbReference type="OMA" id="DMKEMWP"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="64"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="16634" checksum="CE1ADF337EDB1909" modified="2013-03-06" version="1" fragment="single">VPDQPLRLIHKTKNMKLYDWHQSQTHIYINPHVPLTITQSTISTPSHTSILYKNVTSVTLSNGVYVLQKDMKEMWPCLTVETREEVCEEHVEDEKDDSLDGLLIKLYKDGDDEKRRAMDKSFRESGGTMLSTDWERVKGKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU83</accession>
    <name>L7JU83_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">sn-1,2-diacylglycerol ethanolamine-and cholinephosphotransferase</fullName>
            <ecNumber evidence="7">2.7.8.1</ecNumber>
            <ecNumber evidence="7">2.7.8.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.1" evidence="7"/>
    <dbReference type="EC" id="2.7.8.2" evidence="7"/>
    <dbReference type="EMBL" id="JH994013">
        <property type="protein sequence ID" value="ELQ74865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU83"/>
    <dbReference type="FunCoup" id="L7JU83">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2194"/>
    <dbReference type="HOGENOM" id="CLU_035066_5_0_1"/>
    <dbReference type="InParanoid" id="L7JU83"/>
    <dbReference type="OMA" id="SVYANCK"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="378" mass="43441" checksum="AEE7671ADC043055" modified="2013-03-06" version="1">MTSQTIYYANLRSIPMEEREERLNNLRNYKYVAVDKSLLSNYVLNRLWELVVSLFPRRLAPNLITVFGFIFIVFACAVNVYYDYEMVGAAPSFVYYTNAVCLFIYMMFDAVDGKQARRTKTGSPLGQLFDHGIDSLVATLTVIMFTSSLGFGRSLESFLFLASSKLIFYFVSFEEYFTHKFVLSYINGPTEGILSGILVFLVSAIFKPSCWSWLLRNDLSSHVSNISLLGLFFIVVVPLSGVISSIRGIKTGDKLTVLLQALVPIIFYTCFYIYFRQLKNTFNFYVLMLTEAFNFLILIVEMSYAHLTRRDIPIAWPSVTMFAFCVYFTYRDIYLYGLFLFAFISACLIVFGIINEICDALQIGCFTIRNEELMNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUG3</accession>
    <name>L7JUG3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2695"/>
    <dbReference type="HOGENOM" id="CLU_2943462_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUG3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="6909" checksum="BA69E5CBBE888B3B" modified="2013-03-06" version="1">MAYSNMIAYHTGTRKATTRERNGRKKKSEDTRKGPINSTQLIYLLCSHIYVSYTTKSCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUG5</accession>
    <name>L7JUG5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2117"/>
    <dbReference type="HOGENOM" id="CLU_1645005_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUG5"/>
    <dbReference type="OMA" id="YVSDIML"/>
    <dbReference type="OrthoDB" id="10331979at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="194" mass="22406" checksum="A4D44BAAEA4D7A86" modified="2013-03-06" version="1" fragment="single">VNIDLKMFKGYYLDVISISNVPIDLYSAFRLTLMIYVPENSSYLLKFITNNNFTKCTDTVFYKVICYPDGIYTIGSGDMVHIFTRNTHMISKGMIFNLRDNVSLIVKRQSYKLKKSLNSNIPGIHVVEKDDVVVYVSDIMLDGNVKGTYIYSDNCLINGLVSNLTNNFQKYYKVKKSMSYEKDLFYLLRLAKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUG7</accession>
    <name>L7JUG7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras GTPase-activating protein family-IQGAP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUG7"/>
    <dbReference type="STRING" id="72359.L7JUG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2700"/>
    <dbReference type="HOGENOM" id="CLU_011104_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUG7"/>
    <dbReference type="OMA" id="FRINKPM"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="53"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RasGAP protein C-terminal" evidence="2">
        <location>
            <begin position="773"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="965" mass="113228" checksum="39539BBB142E3C23" modified="2013-03-06" version="1">MAENLEIDLNDESKKPIRKNVHDRIEQGSVSASEMDENRKYEKEYEYLCYMAQARDWISKNIHLEMSNNLEFKEELRKGEILVDLANVISGKDMKAYRMNKLVYRHTDNHNAFIDFLREVKLNPCYHYGVLDAYDDVNIPSVIFCLHALSNHLQKFGYVNKIEKKRYVFTEKELSSARKEIKNFSALQFDSIGKDVKEMKKIIDEEYVPSPRRLSRLVNNLCRYRQYREKVNSTKSILKEQIESLNNTIPIVIVEFIKKKLKERISRRLSAKHDEVLRHTLRRFLMRNPMKEVLSGRASLFSIREVLRKQSMDIKYVIDAKHRLITEKLKENYDLETQIDKIMCTIEKVLDNTRLNIGLESSLYLTEYNKNFERILFYMQTEPKVLLDVLGKIDKDELEDFIARYIVPLFSTSSERDKYLILKIIDEDNSEVVSSSLYSEDNTEEDIRLVSYKIVVNLFRSSMMAVEIRDALLITDKVNVSNAKEDYIKSLNTIKDIVTRTMDTICSISMPYYVLYFFSKRGEGRRAADLRDFYNDFISPFIAAPDAFPNFRGKFDRNTLLTIDTVFQGILKGEFDNDYYLPLSSWGTDVRERLEAYFCENINRKTKITGNSKFRINKPMIQFSLKELNQLLGILQVITTKSVEFDNLIKRTRPYEYYDNEFVTLHLSNPVVKDDEDRFAGVVEDIADIVCVTRGRDLESILMSKSTKEEECRYKKLQNYKNNLIRTSTRECMEEYDNANNSDESEYDLLNKDSFVNDEERTESLDTSDSALLDELKVSVCKRIEVLEKNGVLTANKYDELVQKMCERIEEMRILMSQRRMEIKINNKTLSNLKKQNKFLRVRMDTVTEYFQSLLESYFVKGSGNCSKKSVYGTYKYKFKHLQKKNILMAVHDYTVDDPVVLYFSCDRPGVIDIHLVVGGQTVESVCITLEEILNKREEKSVVLGSLEFNSKGLLRLVNDNYVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUJ1</accession>
    <name>L7JUJ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUJ1"/>
    <dbReference type="FunCoup" id="L7JUJ1">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2405"/>
    <dbReference type="HOGENOM" id="CLU_009923_1_0_1"/>
    <dbReference type="InParanoid" id="L7JUJ1"/>
    <dbReference type="OMA" id="YKLRIPH"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="292" mass="33994" checksum="61AAC930D2230077" modified="2013-03-06" version="1">MVTQIDVYKDFQFPTSCTKLKLNNEQTHVIAVGTYPPQYKVYVVEDNTEFFERRMDTDIVDFCFLTHSPRKLAFLRDDKTIEFHLNYNLHYKLRIPHFGRCLNRFSDNLYFCTDKELYRIDLARGAMSRVYNSDYELNTFSVSRTHGLSALFSDGQLAFVDARQNEMVKHINFRENVINGDFDANIIISVATDQNLYMFDLRNMKPFIKSTVTGATKVICHEKHCFVAYSEGIDIYDNVSKIDTLFSANISTFDLKDNVIFVGYCSSEIKTYYTGIGIIPKWCSYAEKYVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUM4</accession>
    <name>L7JUM4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2329"/>
    <dbReference type="HOGENOM" id="CLU_2216302_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUM4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="107" mass="12593" checksum="77A4E4C58B52CA43" modified="2013-03-06" version="1" fragment="single">VYLKKAYETKIDSYERINKCQDDCSKNVCAIGQITDRSEEKRLKIREVFVREEKYSEHKHESTHKELCYTLNGKNTRTGLCCSIEDVIGTGLGRKNEEERLVLEEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUT0</accession>
    <name>L7JUT0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2552"/>
    <dbReference type="HOGENOM" id="CLU_1807583_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUT0"/>
    <dbReference type="OrthoDB" id="10515020at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="16508" checksum="A77B4340E98C1C2F" modified="2013-03-06" version="1">MWGMKNDDIEFVDMVNADIFELNGTGTVNEDLIRVKSKSNHVWDIKSGSNKVIYRYNVYQKPSQHFLVQKRSDEHFKIVISDQECIAYNAPVNYFVKERCRERDMTQLFDVVALFETTKTPSIAAINGYKGLSFSTKAIGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUU7</accession>
    <name>L7JUU7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUU7"/>
    <dbReference type="FunCoup" id="L7JUU7">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2455"/>
    <dbReference type="HOGENOM" id="CLU_040185_1_1_1"/>
    <dbReference type="InParanoid" id="L7JUU7"/>
    <dbReference type="OMA" id="HPIYEIK"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="9">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="KRR1 small subunit processome component second KH" evidence="10">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="246" mass="29061" checksum="B11227D25B847ADE" modified="2013-03-06" version="1">MEFNEEEFKDQFLEKSRFEIVYARHLESTLKENQKRIKALLKEKNVRIKINYDERVVQMSTTSKTRDPYVIIKSKDFITLVCKGVPLQEAERIFDDEISYAMLNIQQLASNKEVFINRRNRLIGPNGDTLKALEMLTKTYILMKSKCVCVIGSFANVLKVEQFVLKVMENYHPVHLLKQLVAKKEVEQCTEKKDMNWKNFVPVVKKKTGGSKQTKRKFNVREGKLFMEMPVRKEDIEMIKMNKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUU9</accession>
    <name>L7JUU9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bZIP transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1906"/>
    <dbReference type="HOGENOM" id="CLU_2428730_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUU9"/>
    <dbReference type="OMA" id="ENNAMKH"/>
    <dbReference type="OrthoDB" id="551672at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="96" mass="11236" checksum="AADA3B417B8E41BE" modified="2013-03-06" version="1">MLHPLMRKASFTDDEKKRKLMVVNRASARKSALRKKLYIEALEKENQSLRDENNEMKNKLENYRKMFAVMLGKNTNSHSVINIPSEYIESTMADCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUY9</accession>
    <name>L7JUY9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Notchless-like WD40 repeat-containing protein</fullName>
            <ecNumber evidence="6">2.7.11.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.7" evidence="6"/>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUY9"/>
    <dbReference type="STRING" id="72359.L7JUY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1842"/>
    <dbReference type="HOGENOM" id="CLU_700570_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUY9"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="544788at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016905">
        <property type="term" value="F:myosin heavy chain kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="394" mass="44835" checksum="4B81DD9AAAA5B33F" modified="2013-03-06" version="1">MEQNPSEIVVIQFYDTSTETTSQSFQVPVKIRRTQLLELLDRKSTLYYSGHIITNDLLSVLPKNFNREETIVIKTSDEKEQKAAVYCSSSFSGHESAVLAVACDGNDVFTVGGDATVRKWDFDMKLQKKISKEHTHWIQVVKILNNMVFTGGMDAQVCVFDKDLNLLCTIRGHSNGITGIGEIEEMIVTSSRDKTVRFWQKKDKNEKIEYECVYTYAHDGIVNGIYVHNSRIYSYSKDSSVKIYEKMRYVTEIKTNSSINTLKAHEKDVYIGCEDGSVYKNNSVIAKQNNLISSIDVSQNGIYFATGSFSKKTCVYTTDGDLIAEYMHFDSVYKVKMVSYMVYSSSKDKTIKIFSLKTKKVVSTLICKDEVYDFDLHGEKVVAACKDGRVYFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUZ9</accession>
    <name>L7JUZ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1852"/>
    <dbReference type="HOGENOM" id="CLU_2322002_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUZ9"/>
    <dbReference type="OrthoDB" id="10372316at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="99" mass="11274" checksum="16C00F22CC024B69" modified="2013-03-06" version="1">MLGNKKLCLVGGDQVTLCNPYDKSVLDDWRFVETSKGTSLRTSNMCLTVSMTPRNFLSSPFFTLRTTPCGSKVYSYFSIDRITPLPPQKPPFFFSSWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV56</accession>
    <name>L7JV56_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translation initiation factor 2B, epsilon subunit (EIF-2Bepsilon/GCD6)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV56"/>
    <dbReference type="STRING" id="72359.L7JV56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1746"/>
    <dbReference type="HOGENOM" id="CLU_036210_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV56"/>
    <dbReference type="OMA" id="NICNGCV"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="577" mass="65648" checksum="318CA96BDA4C0D2F" modified="2013-03-06" version="1">MIKVLLVCDFYETKNIPDSVFTVKKNVTLFPISNIPLIEYILEMLSKNGFTEIILAGSSTSVVLEYLKRTKYHKLLNISCLSNSHTSLGDILREIDEKDWRVDNLLVYYANTFVNYDLRFVLDEHLRSKKKNRNVILTTVLFDEKARKTNNLYGMRGPEIVYYEELGKKGNVKADMWNMVERYGSVDLISNVSKSRVFVISSEAFPIFTENFDFQSIEDLIKGFQVFNAYGYKINAILSDRIPYKRARATKEVINISSISLNSLSFTSHVVTQYSEKTGTCSEGAKNQANENIMSLGVAYGKSITTLQDYFDINTDFRSRRSSPFSLEDYINYPEKHYTCRDGNYIIDDVQVNCSLDKSVLGKSKVTENTMIKSSNICNGCVIKASVIQDCILWDGVSVSKNLSECLVISNDEDGIIYLNQIEETDESEVVDEEECENTFFTDVVNYLLDTYGDISSFKMDVDEVLKQVNLLRIVWNASRFDLVEAFGIFLAEIYDPKDTEGSTINASLFFPILIGITEDTNSQDLLLTSINSHLTGLDNKGKKEIVSRYGFLLLEDGLVSRASIKKYRNLIKKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVB8</accession>
    <name>L7JVB8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1671"/>
    <dbReference type="HOGENOM" id="CLU_580849_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVB8"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="471" mass="54519" checksum="14DF74423B962215" modified="2013-03-06" version="1" fragment="single">VTRNVSCTIFIYEKPGENCKRMAYIPNGNIKTKISIFERITSLKLTEESVREIKIIPRVFLINHTSFPKTEEYLRSKKNHIFLTFEDDEHSYNNEVRFSTRTSLIECISFIRVVEFWLQLDSQNTVIIRNTYRNSLSFYMLSLVRYIQDVTFDKAYEMVKENMRNVEMPKKSHRLYFENYLNGNEFKTLCLHQIVISTLPKKQIENSKPFGKPFYSLRIMEKPTISTVIHDEHHVICKVDAAVAGDVTLVLNRNNAKLFTLFLNTNSFEEGLFRFSKDDLVLDSGTILEADFTIDIIFFKTDKKSKVYDFNGKSLVISKFVGNYNENLLNRLKGEGYSKDDAMIATIVANSSTEVNKVLQKLEKKEKPKISAETSLERPYTPNDDVTLEDINLIVDIMPEKENAKTKKKMLPPKNAPKTGVTNSLTVKPFYWAVIPKSCDSIFNELDEVHTQIDFVKIRGLVLHYDRLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVC4</accession>
    <name>L7JVC4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit E</fullName>
            <ecNumber evidence="4">2.7.11.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="4"/>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVC4"/>
    <dbReference type="STRING" id="72359.L7JVC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1676"/>
    <dbReference type="HOGENOM" id="CLU_073901_2_0_1"/>
    <dbReference type="InParanoid" id="L7JVC4"/>
    <dbReference type="OMA" id="IVNTIHV"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="175" mass="20638" checksum="8C1372C8E48C788F" modified="2013-03-06" version="1">MFRTILIEDNISILPTSKDHLTSLYTATNKKYTNRIIPNEGIGIRVKEIKKIYGKELVEGCYTVHLEFILITYKLFKDEIVEATISKQDENGIYLMHPIVNTIHVKTLFPGTEKKYFVMKDSPEKHMCWCWTYKNDNFYFKNGQFVRCKVVHVSYNPFVVEARMDDNGLGPKEWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVG8</accession>
    <name>L7JVG8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1617"/>
    <dbReference type="HOGENOM" id="CLU_2819741_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVG8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="67" mass="7696" checksum="6B529305BDE367BD" modified="2013-03-06" version="1" fragment="single">VLRRIFEGSPVFYIKGLKGRAGKAMSPGRALNKSLQKCLIIKKYFSLEKDKAIFKDYMIRTVMTNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVH7</accession>
    <name>L7JVH7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2031"/>
    <dbReference type="HOGENOM" id="CLU_3108109_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVH7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979068" description="Transposable element encoded protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="6278" checksum="1069225B8EDF33F2" modified="2013-03-06" version="1">MVFLHVMLFLNLIRTVFVDGRHEIDYAHHSGRNLERWYFEDSDDKLFKPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVK4</accession>
    <name>L7JVK4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin complex component, TCP-1 zeta subunit (CCT6)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVK4"/>
    <dbReference type="FunCoup" id="L7JVK4">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1600"/>
    <dbReference type="HOGENOM" id="CLU_008891_3_1_1"/>
    <dbReference type="InParanoid" id="L7JVK4"/>
    <dbReference type="OMA" id="KNAIEDX"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="474" mass="52394" checksum="8BDD77A9DB40AEFA" modified="2013-03-06" version="1">MEQIGKNTEITQSGQAIRINLSAFSGLNALFSSSLGPASTTKMLINSAGIKVLRDGRSILDSVMFTHPVTTIINKAAVQSHDLLGDGVCTFVVFASLVFQNAFAQIASGQNVLKVNERILKDLNLLTEIMGAQKVALAEEDLSKLLFYVLNTKMGRDAAHHFTQIVLNAYRPNLQMVEILKMDGDLADSAAIDGLVLDHAGRHPMMPREVLKACILICNISLEYEKPEINTSLHFKSAAERESFVAGERAILNRKIDRILELKSAVESAGKKLVLMTERGIDLPALDRLQGMLCLRRVKRRNLERLLRLCGGRLVSAADDVRMECLGYAGSILVKEYKDKAYTYVTKAPYTGCSTIVIHGTNSYEMERVQIALKSALKMVELVKSAPFYVKGGPMNYKRWSEQLSAVNKGRTAVSEALYQLYNTIRADDEDVMDCFVGLSRTLFNAGMVSSTLLMVDEIIRAGKSVKEEKNEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVU2</accession>
    <name>L7JVU2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase sigma</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVU2"/>
    <dbReference type="FunCoup" id="L7JVU2">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1461"/>
    <dbReference type="HOGENOM" id="CLU_013572_1_0_1"/>
    <dbReference type="InParanoid" id="L7JVU2"/>
    <dbReference type="OMA" id="QQPYIKD"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="128"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="288" mass="33597" checksum="EE0CBF3DBB9F0BE6" modified="2013-03-06" version="1">MQGDYIQIKSNEESRPYVVFDALAFLSINPKYNQSRKISFMDHLNNELRQFIEFLRPSDEEVTLRRVMIKRVKELILNGLEEIKRERTCAKEGNGYFDNTSKIREKDGIENKSDDKSAVEKNENQICEDRVECFGSYETGLYLPGSDIDLTLFTDEKDALKKLQGFLCTSPFIFTKSVIFLSKARIPILRFMDVCHFRYDLSLNQESGIIHTRFIKKALKQQPYIKDLSLFLKYFLKSRGLNESKRGGLCSYAQLLMLINFLNLHPLVQRQMPVAPNLSVLFMDFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW22</accession>
    <name>L7JW22_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ75629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="98" mass="11453" checksum="C166DAFC12D32931" modified="2013-03-06" version="1">MKHQLNSEKQADRINATIMSPEFSATDITDKKMVKICLQFDDTKCINQVNGENNHLLDSGYKEYIDKLKDLPVGFKKFLDDIEEFFRINFEIYGECHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWD8</accession>
    <name>L7JWD8_TRAHO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5777" checksum="505C6A12BA9331D9" modified="2013-03-06" version="1" fragment="single">VLDNYLSEYCTRFMDSCERYFDDDLNRLPIDKRIQYVRNGNVISTPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWE2</accession>
    <name>L7JWE2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="L7JWE2"/>
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    <dbReference type="OrthoDB" id="2192848at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="327" mass="38429" checksum="0070E777501CC78C" modified="2013-03-06" version="1">MKMKADEVEEEKQNLVVEKQVDNTIDFDKTIGDLMEKDLAEGIEGLRVIEVSLGIQDLKFADETEQNNELLMKKEKILKAKLGLYNKNIANASYNAYKSTLQDYIRVNELLSKDGNVIFYVKMLLKVKHDTIDLIRFLSTIKEARKIYQDQLFFSSVDAHNKKEILRVDGQQDSDAFYDSLDEEFKLAYLLRTQYDNAVTYFYDDQNANVQYNDKILKEFAVASFQKEDFKLTNDIIGRIAKREEELDDIIVVLEILGVRKPEILKDKFVMLEKNELMLKSTNRRMELMRAYFMCINWDFDECTKIIKDEMGIDCYEIVKERYCSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWJ0</accession>
    <name>L7JWJ0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWJ0"/>
    <dbReference type="FunCoup" id="L7JWJ0">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1620"/>
    <dbReference type="HOGENOM" id="CLU_008037_2_0_1"/>
    <dbReference type="InParanoid" id="L7JWJ0"/>
    <dbReference type="OMA" id="QFEQHVT"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000154">
        <property type="entry name" value="Vesicle-fusing ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="234"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="551"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="724" mass="80692" checksum="990A980545AF90EA" modified="2013-03-06" version="1" fragment="single">VPTPTMPDQIRLKVKKPLMPASLYSPTIAMPALFPPTSLVSINNIIYAHNALPTSNRVIEMNSAQRENHNVAIDGEVTAKEFTGKLMDITLVKIKLLPVRAGDKTVGRKEMTERFISLYNNYPLSLGQLFYMKYEDDPIKAEVCEVMLEDGEAREDAVNVCGMVSYKTTVHFFSESAHLAIDQPSDENMLLKTNFNFFSLGIGGLKEEFATMFRRAFLSRVYKKDLMDRLHIDHVKGIMLYGPPGTGKTLIARQIGRLLNAREPKIVNGPEVLNKYVGQSEENIRELFKDAEKEWRKKGSASHLHIIIFDEIDAVCKKRSENSSITDQVVNQLLSKMDGVESLNNILVIGMTNRMDLIDPALLRPGRFEIHVEIGLPNLEDRKEILEIHTAALKKNNVLDGVSLEEVAKQTNNYTGAELTAVVKSAVSYALERGLKRKTGSAGDDADSGIDEGSSDAGSENGGDNYCTGSAAGRQGASGESSPNTIRVSDNIRVTMEDFLKAIDEVKPAFGLNEQEFTIFKKNYYSLRHHADIMQQIKEKIAYLLKTTFYNTSNILLCGESGVGKTTLSVRAALSMKIPYVKLISPREVIGYSEVEKIQFIKEIFINGYKCKQCLIIIDDIESLIDYVPLGPRFSNAVLQTIKTFVRMESNGKCFVIATCSSLEIMEELSLRESFDSLVVVRKISGNDIEELKEQNEAFGRVECGEIGIRELLGMLDICDLATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWJ4</accession>
    <name>L7JWJ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993917">
        <property type="protein sequence ID" value="ELQ75848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1200"/>
    <dbReference type="HOGENOM" id="CLU_3191630_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWJ4"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5109" checksum="32FD92C5EB937EB6" modified="2013-03-06" version="1">MRVATMNAYSGVKYIKANGSVLGAFNNASFCEYFLVIIGEMNRVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWK9</accession>
    <name>L7JWK9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phospholipase A2-activating protein (Contains WD40 repeats)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1270"/>
    <dbReference type="HOGENOM" id="CLU_320589_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWK9"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PFU" evidence="5">
        <location>
            <begin position="461"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="905" mass="101712" checksum="28B8591A6FB4A674" modified="2013-03-06" version="1">MFLKNTRTAKLHTTDIKALAHLPNTIVSCSRDKTLSFFTDDLRLIGRVEMSFGYLTALAVDERYVYVGSEEGVIVVYRRDDIDDYLRDDVEGKDVEVEMKRGKEEVSNKDNNKDISTKDNNHNARDRKDFQNINSNDKNNNIKDKNISSNDNNININSNDNNPQNTNKQLIPHTYIINHSKNITSLHSDNTILISSSWDNTMTVTDITTHTKIYSYTHPSGVWCVRKDERYIYSACMDGCIRMFRDYAVVGCINMHGGCVRGMVVRGDEMVGVSNDGRVLLFRIGKGRAVGKGRADDEDRANDEDRANDEDRDKDSNAVGKGRDKNGNAAVEGNAITNSSPSTNNANLSLNVTNANIVKAARAFGTYCYDVIAINHIYIFLADDGVVYITDQSLQNVRKTCIGSFCWCVTHKDGLLFFGGANGNVTTLRIEELIEQSTDAMAIEKGPANTNENDQLQEIKKKMKNNDNYRIEGTTLFQRQGDTWVHVGQVVGKRDNCFTVEIGNRKLELGFDNDENVYDVADRFLRENALGEEHRDEIVEFMRRNFKKCGMRKFKGLDIDGLRKYAVDEDLVRVLESINEYGVKYNYDVGCIEGDVKDSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWL2</accession>
    <name>L7JWL2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1640"/>
    <dbReference type="HOGENOM" id="CLU_3015874_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWL2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6706" checksum="11E53D71D358DCA6" modified="2013-03-06" version="1">MCHRSCTLRMTKKNNLEEIELKDLDYLKISDIKNDNSEISKELRAFYGKLFGYKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWU6</accession>
    <name>L7JWU6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex, Nup98 component (Sc Nup145/Nup100/Nup116)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993947">
        <property type="protein sequence ID" value="ELQ75536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWU6"/>
    <dbReference type="STRING" id="72359.L7JWU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1507"/>
    <dbReference type="HOGENOM" id="CLU_532312_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWU6"/>
    <dbReference type="OMA" id="DITAMNC"/>
    <dbReference type="OrthoDB" id="2191699at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S59" evidence="2">
        <location>
            <begin position="393"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="511" mass="56836" checksum="5C0A87F0C88C3FF8" modified="2013-03-06" version="1">MSQNDRKPFSYFGSQPSQNYQTPFLTNYSNENRSTGLFGQKSAADAPTSAQPTLGTDNLFKSGFGANTNPFSTTNNYFSADNKTTTYPSTTGFGAPATRYTPMTSGTTYDTSGYSSFKAPSTTYDYTKPSWLSSTEKRGSSVEAYKKTHTRDDTMILVELLDITAMNCYNGKSVDEIRYEDYELGRKRAVSKPLTTGAGLFGSVSGTGPVQPASTAQPSFLQGLSSTTPGSTIGSTTSNVYNPVSAPSSFLLNSRPADTTVQPTQSIPFQSQSLMNQPIQTQPFQTQNTSVVPPVPAQPSFMSAQPSMISSSVQPTTFVQPTALYTPQPYYTPAQPVSMPSAQPLVSNYNLEDPYLVEGLTFEHIEKPSIKLKKNFYKSIFNVREPDHKPFIRMNKHTNTKPYSIPKYEDVIEQNQVSNPSIVFPGKGKIEFLESLDSYLLREENIQKYVFDSRGVSNVLGKRARVYVENVKPTRRENVERFVYELKNDKFKKFVDYNVEDGIYVYESDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWV4</accession>
    <name>L7JWV4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin regulatory light chain, EF-Hand protein superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWV4"/>
    <dbReference type="FunCoup" id="L7JWV4">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1820"/>
    <dbReference type="HOGENOM" id="CLU_061288_9_3_1"/>
    <dbReference type="InParanoid" id="L7JWV4"/>
    <dbReference type="OMA" id="GVNFTMF"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="162" mass="18604" checksum="13C1E81A5327A529" modified="2013-03-06" version="1">MKQRINRRRQPSNVFSMLTQTQISSLKEVFNMIDNPPDDKIDAADLNNFLPTIVNQDQLHEFENLEKDIGFYALLAAISDKFIGMSSKECIRKSLLSFSDDNVTVNKSELMNYLRCEQLNGTDLEYVFGVFGDEKMLEIEKVVNLIKHGEIEPNAEKKRIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX54</accession>
    <name>L7JX54_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX54"/>
    <dbReference type="STRING" id="72359.L7JX54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1402"/>
    <dbReference type="HOGENOM" id="CLU_2039703_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX54"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="13683" checksum="B970746295D6A0B6" modified="2013-03-06" version="1">MDVRKSLNIMQALAAILKNDQNVKNDADNDALIDDFIGVIPSKTIDAFKKLSIMDVKMFVTDFMNNSFSLVQFINQIIDLDLPVEFYGVIGEVEEMCVRGGDTELLLHFLCSSYIEIRKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX85</accession>
    <name>L7JX85_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993877">
        <property type="protein sequence ID" value="ELQ76083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0946"/>
    <dbReference type="HOGENOM" id="CLU_2039702_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX85"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="13867" checksum="CB8B8CE979E50B79" modified="2013-03-06" version="1">MSSPGDLRKQSIKMGFDKFSVFRSLWSRNHRQSATYSEMNADSFSETSDLGCLSDPGTDIRTNDDIFSKPLSSDICRKQSSRKGHDNFPSSESTNSTDLRKWMFQCRKYNNIPQRPDAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX90</accession>
    <name>L7JX90_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1659"/>
    <dbReference type="HOGENOM" id="CLU_916925_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX90"/>
    <dbReference type="OrthoDB" id="2190258at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="304" mass="35825" checksum="C1873524C4CD9A87" modified="2013-03-06" version="1" fragment="single">VSGFCKHRKMLSHLLLPNIGLLINDLFLPVKKITLNQKCVEMNLISSFVQFFRELGNVLVVIRHFESASVHELFMYEANNVLCALLASVSVTYNYKDLLVMLNTLYFVETTFLDLTENTRKWGCTSNNVSAYVRKLEKKVTTGIESILKVIFRRSVKKKYTFSNEFIEMLKKEVLVLDRIEFNESIFHFLFETLFSLLFSKMVKFKMEPRLAELLIEEIGEIRLFLEEDWPKPPLIDVIESYLKIFVCTTDNIRVFVTCFNQLNNNLFDFKNIIEALEDSSRNKQLVREYENQKNKIIKYESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXC8</accession>
    <name>L7JXC8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXC8"/>
    <dbReference type="FunCoup" id="L7JXC8">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1075"/>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="InParanoid" id="L7JXC8"/>
    <dbReference type="OMA" id="LVVEMKF"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000105">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="16832" checksum="F555CFF6DD3227F0" modified="2013-03-06" version="1">MEYYIRELREQDFDNNFPQVLSGLTTVGQVDKHSALQLYTTLMDKKDYVILVVLKNGCDRVLGCATVFFEYKFIHGLSVVGHIEDVVVEEEHRGQGLGGMLVNRLVEIAKERGCYKTILACSERNVRFYKGIGFEEKEKEMAMYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXH5</accession>
    <name>L7JXH5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1598"/>
    <dbReference type="HOGENOM" id="CLU_1835149_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXH5"/>
    <dbReference type="OMA" id="RIDCVAL"/>
    <dbReference type="OrthoDB" id="5594797at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="151" mass="17277" checksum="871A70764DFA8F9A" modified="2013-03-06" version="1" fragment="single">VFEYLGLPLTLDLDLNIVIRDRKEKAVRAYHGMRPFFTWKFVPAPIKMLLVKSVLLPIATYGCELYGMSIARLAPLQRVIDHALKDILSCGSSYCRKAAYEELRIDCVALRTAKLRTRAFLKWNTSRTTISELMNQSFKCSSATWITGTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXH6</accession>
    <name>L7JXH6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E3 ubiquitin ligase</fullName>
            <ecNumber evidence="13">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_1299</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.2.19" evidence="13"/>
    <dbReference type="EMBL" id="JH993929">
        <property type="protein sequence ID" value="ELQ75741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXH6"/>
    <dbReference type="SMR" id="L7JXH6"/>
    <dbReference type="FunCoup" id="L7JXH6">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1299"/>
    <dbReference type="HOGENOM" id="CLU_009169_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXH6"/>
    <dbReference type="OMA" id="ANLTMFT"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ75741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="327" mass="37856" checksum="462E5E4431570AB8" modified="2013-03-06" version="1">MKYLFLYTAVHFISLLIFSYREYVVEESIYSVFIRTTNNNGLHLFHAAFLILLLFISGKLLVTLFLDGIRSEEQSTINDNCFMFLTDTLLIISIFSEDISIKNLILFCYLLTLKCLAWVFSERVTQQNDRMVISFGLLIIMQSLTSFILSLKSSLEEPNVQILFTFEYGIVTLTCIKSLISMFLEDSIKLFWVDITYVTLKLVAHIFFFCFTTMHYRIPFNVFRECFSTFKTLFKKINNFRAFLKISKYLETCPTVSTGTCAICTEDMEEEKGRIIKCKHSFHLVCLKRWVEQQQVCPICRDVIMSKEGDKKRGAEGSLVGIPVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXI4</accession>
    <name>L7JXI4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome condensation complex Condensin, subunit D2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXI4"/>
    <dbReference type="STRING" id="72359.L7JXI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1284"/>
    <dbReference type="HOGENOM" id="CLU_586880_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXI4"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="466" mass="53923" checksum="C0CA69C58E6EA70F" modified="2013-03-06" version="1">MNKKKVIDRELVKTLFRKFHDGIDVVRTTRLLKNMCYKRAEDNVLDKTADVLLTDNIREDDINVYKNVLEMVSIRPSMPDVKRCISNLALMKVVDFEIIDLTVQMLYKMPDPEPLCQLLLEKLCTENKNLAKIIYTVGSIAINESFFIDKLEKKVPKIHVPREIREKRKSFNVTRTSFRQSINFSMHERDLSSSFDMSLRQSQDIIDGQAGLKNKTSDEIADILFYIKEKEILCGSNSILAPFIKIVVENCKTPDLDVVAYVSVYRMMAVSSEFFLNHFSYFISGLKSANTLVRYNSLVAMADFILLYNSYVEKYSYLLFDKLFDENENVVKLALFIIYHLVSSKILKIKGYGAVLCKLHETQHSDTIKSLLSSLASDENTIASIFYEVMLDEKSRNMEVIQFIKCLVKDKTKENLFLKILQKFKKEERMGDVFLGQLYSILSFGSKSVSDMRMNEVFNTWIAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXN9</accession>
    <name>L7JXN9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Poly(A) polymerase</fullName>
            <ecNumber evidence="12">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">THOM_0866</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="12"/>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXN9"/>
    <dbReference type="FunCoup" id="L7JXN9">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0866"/>
    <dbReference type="HOGENOM" id="CLU_024144_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXN9"/>
    <dbReference type="OMA" id="ELEDVPM"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="320"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="15">
        <location>
            <begin position="380"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="14">
        <location>
            <begin position="563"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ELQ76169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="696" mass="80162" checksum="C9B87686BDFE2281" modified="2013-03-06" version="1">MHLPHSKKHGITGPLSLKESSQDDIARTSSLHAFLVSSKIYDTDEEAIIRERVLGRLSYMFDNFIKAIGTKKGLADSDIRTATGRIYTFGSYRLGVHARGSDIDTLCVAPVYVDRKEFFEEFYVMLNDVFAEVEKVEDAYVPLMQLVYRECVDEGGTMSGGNKIGILDTAIDNIDDLRSCRVDERSKRVRVNERQAVDEHLKDEERNDTCIDRKCGDKHVVSTLMGQDRNGMLKRTRYGQDEKEKFSDVLHEKEGRNEMLNGEKERNDVLNEKEKFSDVLNEKKELNNTKTVEIDEKDKPSSVPLNRPGNKRGTGPGLNKKMVEIKIDLVFARLNLFKIDGSLNLLDSSLLKNLDEKSVLSLNGNRVTDEILSLVPNKTVFHGALRCIKYWAKRRALTGHLYGYFGGVAYAISVARICQLFPNVCEYTIICKYFELYKEWKWPMPVMLKKIENLNYNLKVWDPKIHPSDKFHKMPVITPSYPSMCSTHNIMNSTMKRYKEELERAHKLLVEGAEWNEFFRGTDFFQRYRSFLAVFILLKNAGCTTNNDARSEQEITNEQASGAKETSMHKMWQGHVNSRIRFLSTKLETVEQLDSAPPFPQTFDMCGFLGLHPLAFIPKNALCSLTFIALDMADSKQLLRKKVFIDAPIEEFKEMVFDWDKRTEDMDLVMRAMKRKDVNVLLEDLHDFEMKKERGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXP3</accession>
    <name>L7JXP3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXP3"/>
    <dbReference type="FunCoup" id="L7JXP3">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0784"/>
    <dbReference type="HOGENOM" id="CLU_025885_0_1_1"/>
    <dbReference type="InParanoid" id="L7JXP3"/>
    <dbReference type="OMA" id="HPGSHLR"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978956" description="Apurinic-apyrimidinic endonuclease 1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="70"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="326" mass="37403" checksum="F0763913DEB61D9E" modified="2013-03-06" version="1" fragment="single">VVWCAFFILFSFPFSHFSCLLSRKFLTSRPNILNFHHRPKHHRMTNRKKILIGAHLSIAGGIWKVQERMESLNATTCALFLKNQRRFAFTPLEPKSIQKFKKLVKNADVLVPHGSYLINMARNDKAERKKHFECFHDDVARCSSLGIKLYNVHPGSDVDNLGKKALENVADAINEVNRMEPNVTIVIENMAGQGRVLCSKFEGIRDLIELVHDKNKIGVCLDTAHLFGSGYDLRTKEKCERTFGEFDRIVGMKYLKAMHLNDSKEDLGSKKDRHESIGKGKIGLEAFKFIMKDERFENVPKVLETPDISCYKEEIAMLRSFAEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXQ2</accession>
    <name>L7JXQ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0833"/>
    <dbReference type="HOGENOM" id="CLU_3244854_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXQ2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="43" mass="5474" checksum="788CC8B139ECD09D" modified="2013-03-06" version="1" fragment="single">VKQAHFHIFFVYEVSIWMILMKNRWFMYEEWGNALRSPFDMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXT3</accession>
    <name>L7JXT3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993872">
        <property type="protein sequence ID" value="ELQ76125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0906"/>
    <dbReference type="HOGENOM" id="CLU_2456345_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXT3"/>
    <dbReference type="OrthoDB" id="10589486at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="10111" checksum="2C48B4B387935C5F" modified="2013-03-06" version="1">MSTACLVPLRRVMDHALKDVLSCGSSYSRKAVYQKLRIDCVAMRAAKLRKRAFLKWKASRTTIDELTNQSFECHLDHWNGALVAQSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXU3</accession>
    <name>L7JXU3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative RING-containing E3 ubiquitin ligase</fullName>
            <ecNumber evidence="12">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="12"/>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0728"/>
    <dbReference type="HOGENOM" id="CLU_055016_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXU3"/>
    <dbReference type="OMA" id="PYWERTH"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407:SF0">
        <property type="entry name" value="FI05221P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="RNF121 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="346" mass="40053" checksum="0ED7CF394C1E0D05" modified="2013-03-06" version="1">MIPCHHKMSKTSGETLANKNNNDDNMLKKQEESDEDSHVAHKNDSDDGDTIVLSSRPINMTRRTMLSIGPGGIPIIRDIIIIETEASLSRLLYVLGLLFVYCVIMQSVLLLWERYYPRSCKLTVGAILWFFPFFYAIFNKKYVFIAVWVFYNLMLCILFKNVFFRPIDRNAPRRIYSFFNRFFQVCHFNVISCIVGMAASIIMQRSWLMNIFLVVFIYILYFAVLSQEIITFNSELMAFNVGYYSKDAVPAKVLTDPTCCALCDHKIDSQSITLNCTHKYHASCIKGWFLISKKEFCPLCKEKMGVEKLVDGFVKGEMYFAVFMDILRRGIVFCLMFVLVVLYGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXZ5</accession>
    <name>L7JXZ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Golgi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXZ5"/>
    <dbReference type="STRING" id="72359.L7JXZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0650"/>
    <dbReference type="HOGENOM" id="CLU_1760070_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXZ5"/>
    <dbReference type="OrthoDB" id="10409494at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="17079" checksum="2EB291414D3D6B9B" modified="2013-03-06" version="1">MDESTIRRRDIQSSAKTHKFTLTEELMILSSLRKKIYKILDPLSVAIRACILADLNYQNIITMDYKKGCVVVKDTITGNVLDNPLMDDVVYRIGLYKTSVSKWIRLLNGESYKRSEYYLKKVRKRVLVGLQNKKAVKFREQVLLSGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY52</accession>
    <name>L7JY52_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY52"/>
    <dbReference type="FunCoup" id="L7JY52">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0677"/>
    <dbReference type="HOGENOM" id="CLU_084513_4_0_1"/>
    <dbReference type="InParanoid" id="L7JY52"/>
    <dbReference type="OMA" id="LACEDKG"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="7">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="15867" checksum="B263FDC3E2054196" modified="2013-03-06" version="1" fragment="single">VNLLQATKRTKFLNPKMSTKNDDSISPLATPSLTKRILTNIEEYRKRSIKKGANEVTKMINRGKAMLVVLAADCNPIEIIQHIPVLCNDKDVSYIYIESGEALGRACGVERSIAAATFYYDSDEAYERMRVNVGGIINDIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY54</accession>
    <name>L7JY54_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase</fullName>
            <ecNumber evidence="6">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="6"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY54"/>
    <dbReference type="FunCoup" id="L7JY54">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1329"/>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_1"/>
    <dbReference type="InParanoid" id="L7JY54"/>
    <dbReference type="OMA" id="NNFGVMR"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="20567" checksum="8C8BEA7E699C9C9D" modified="2013-03-06" version="1">MDTHMAISRNIPQAYTADLTFEAVYKDKVKTISLSDYANKYVVLIFYPFDFTVVCPTEINAISDNKSKFEDANSVVLFVSCDSIFCHQAWMKISRADKGIKGCTWPIVSDYDRSLTQYFNIAEPAGNCARATVILDKKRNVVYFSVGDKRMGRSVDELLRVLHMANQIEKTGGMCECNWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYE3</accession>
    <name>L7JYE3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993883">
        <property type="protein sequence ID" value="ELQ76071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0959"/>
    <dbReference type="HOGENOM" id="CLU_2442427_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYE3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="90" mass="10296" checksum="7BA239B76F537B7E" modified="2013-03-06" version="1">MYTSHAYKIKTAVLIILNRPKKCAGRWKNKNAVICSHGTIAEEVFCYGFNKELFEMKRSSEIRTRSIITRVLLDASKAIFPSDCLRTRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYF6</accession>
    <name>L7JYF6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0573"/>
    <dbReference type="HOGENOM" id="CLU_1232500_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYF6"/>
    <dbReference type="OrthoDB" id="10573356at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="225" mass="26202" checksum="AA29624F3E00A31D" modified="2013-03-06" version="1" fragment="single">VIITNYVNDTYSVLFNDSTKKQYDGCLKAAVRFRNSLLVLIMKNDICFLDILEEDSIDSIELNHNFDLLAVYDDKILLVKHEKIFLYDLTFKYDSKKRKKYEVKANGEVYIITSSPILKVVVRHHYIYLITKKDSLMIFYKAKLKYSIFETQYLANFEVLKDDLIITSDKIGIVRIYRINSDLKLIFVQDVRDILVSIALFENVIYYLTGSGTKGTIQIELGTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYH0</accession>
    <name>L7JYH0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0931"/>
    <dbReference type="HOGENOM" id="CLU_3335898_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYH0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="38" mass="4442" checksum="F9BAD35DEDB40854" modified="2013-03-06" version="1">MKKIEVNDEQGEFYPNAKDESETASVVRQGNMLDWRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYQ0</accession>
    <name>L7JYQ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0554"/>
    <dbReference type="HOGENOM" id="CLU_615665_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYQ0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="445" mass="49989" checksum="EAC70A73EDD6C525" modified="2013-03-06" version="1">MRHGKDDLVKNAASLKLWEENDELFAKEMLKFKEIKVPDKFELSFEDDGKAVESEQVVLHPSTVVAQHDDAGLNIREAANVQMGSFNENLPQSNPAVNLGQKISATHKHAAHSTQGDQRFVFAGNEVINENSANAQNTYTNISNKNQDFYFEDEIDKEEQKSEINTEGTIQPIDENVIICDNEHFNFFGNQDLKFENLDKFSVMTQEEFLSRSAGSVSQEVIKEDEDGLIHGQESIVNEAYKPQKDIRADRTEKAPVQGRKYDDKHYAADQQELGEKTIVQQLERANMEYKNANGVSFGDINGDKHSNNEQIVLLDEKSSSVKSTEVYDQVDQEFDDLSATMPSQVSRDSCNDEQGNTSKYSFLEESFNSLGVTEDANIVNMPTLNEGDMSSGSVFEGSCVKNRFEDAVEESAAADKTQIGEFSNIGTVLQFNKRTLRKESDDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYS3</accession>
    <name>L7JYS3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0329"/>
    <dbReference type="HOGENOM" id="CLU_998144_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYS3"/>
    <dbReference type="OMA" id="RNDERKH"/>
    <dbReference type="OrthoDB" id="10545474at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979263" description="Lipoprotein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="32062" checksum="D488E325CA0FEA7F" modified="2013-03-06" version="1">MLRIVLCINLLLITVCGCTVSQSSNEEKNDMSKQLINWFFKEKLLSMLGTGLKTANVEANSVLTRIKPDESLLSEAVEQYSKNKNKKNLLGNPIFDDNGNLIILNSNGKDKSSLKDHDSENIRKTTVTNDSAYVKRTPDGENIVEFERQAKLSSNPNIRKQHYKNYELCTDSVPTCREKRIVRIYRNDERKHLENYSSSSDGGSIDFDSSHYADIKHHDAPVKKRTYSSPHSMIYTINEYYKSKPYQRKVREISMYQIPGNQINPLIPISRLERHNIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ00</accession>
    <name>L7JZ00_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperones HSP70/HSC70, HSP70 superfamily</fullName>
            <ecNumber evidence="6">3.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ00"/>
    <dbReference type="STRING" id="72359.L7JZ00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0387"/>
    <dbReference type="HOGENOM" id="CLU_005965_7_0_1"/>
    <dbReference type="InParanoid" id="L7JZ00"/>
    <dbReference type="OMA" id="MNIGICV"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978910" evidence="5">
        <location>
            <begin position="23"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="706" mass="79381" checksum="3988B1526A7320B8" modified="2013-03-06" version="1">MLWTFQLVILALTVLRTILCEAVRDPDDIRDETQDAGESLAKGWAIGIDLGTTYSCVGVVGPTGATSMEILDLGQGRQTLPSVVKYIPYRDEVTKKQQYMAKTGWEVYNENMRTPSPNTYLYAFKRYMGLSSLQDDPSLSGIQKKVTYTLEEVVNEKDPSKKSIYMLIKDVNDNVVKRVSAIDASAYILEHLMKVVNDRYGAKNIANVIITVPAYFSEMQVQATRTAATIAGLSLSRTVNEPVAAAYAYQVRNKDRSAALDSFLVFDLGGGTMDVSILEYEGGVLEVQTYSGSNFLGGENINDCLFKHFYGLMEKSNILLNDVEKLRLRGFAERFKISLCTRQLEEGGDAEFEDEFIYLGDKVFTFKLRTSEFNKVCDEVSKRIRHYLTGDVDGILYKYKQKLDKDKDDIKKVLLVGGSTRVPFVRDILYGIFGKDKVSAELNPDTVVAEGAAYYSANMLNYLLDDSIHLIDVVPMNIGICVDSDTFESILDMESAIPATQTKTFTTGHDNQMKVNIRVAQGLRYQYHKNMHLGEFELTLEKPQPRGVPQIEVTISIDKQRDIHVTAVDKLTKKEAKIKFVKTDYELSDARRSEMLKDRESNKAADERMKVKDQRVKELENYKDVVNSAAQQPTVAQEVRVEAYKAINKLDDFLREAKNPLGGVSADDVSLRHKEFEREVMPLMSAAGAKPAEAVPEAEKKAREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ26</accession>
    <name>L7JZ26_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-binding protein</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ26"/>
    <dbReference type="STRING" id="72359.L7JZ26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0414"/>
    <dbReference type="HOGENOM" id="CLU_062267_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ26"/>
    <dbReference type="OMA" id="CKCDPHD"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="163"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="324" mass="36960" checksum="A6A505C6FC1815E7" modified="2013-03-06" version="1">MILSYTPAEEDLLFAISYLNLPIELQESDIFSLKIQDEEYVGIKNVMNQLISLCKCDPHDLDLLNDEVVAEIQRMRQLSPRKVLVSLTQHKKECDGENVPSNIPLHNYINGKFLTLADLVLFARVYKSIKEGVKYSLVEKGWFDEFQARLIKLIEFKEIEIVDFEMLDIRIGRIVDIKEHTNADSLYVEKVYLGNDELQVVSGLRGKMEMEDMKGKSFLFIVNMQKSKFRGEVSNGMILCAKDGDNLEVLQAPVDIPGEKLYLAGEKRPVIRNFNVPKISKSNEAFSEVMSELKIRNNKLVFKDKIVLCAGKEIMSKLSNASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-05-03" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ34</accession>
    <name>L7JZ34_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0424"/>
    <dbReference type="HOGENOM" id="CLU_1305646_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ34"/>
    <dbReference type="OMA" id="CVRICNT"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="211" mass="23649" checksum="DB1016F3004E52DF" modified="2013-03-06" version="1">MFKLYGQSLQTEQSSILSVDQNGFALAFFFDKLEIDTEWLINNKDTLDTVFTDSMVASLYSVTIKNPKNVCENTNMVNILEELLNTIATSKFLTGKNVSELTLELNGIYTEVNMSCLKSVNAPITVSCTRFSLEFLTSIPSFIKIRANIDECLSIELFNAFPKNVVHISYNKGNLHANMTIPDHVESVHIELGGWGPDETLTLSQNCKTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ42</accession>
    <name>L7JZ42_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0393"/>
    <dbReference type="HOGENOM" id="CLU_2838362_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ42"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7708" checksum="1AEA17D4F6FD03E4" modified="2013-03-06" version="1" fragment="single">VQEKSDLVNERNIIAEKIISELLQSIDALKKERKEMKNSYFKIKTGMKSLFEINTGKQEAERNVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ43</accession>
    <name>L7JZ43_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vesicle coat complex COPI, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ43"/>
    <dbReference type="STRING" id="72359.L7JZ43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0692"/>
    <dbReference type="HOGENOM" id="CLU_021042_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ43"/>
    <dbReference type="OMA" id="DDECYIN"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="793" mass="90547" checksum="A11DD06FC2D7FCC9" modified="2013-03-06" version="1">MSSKLLTEIKSAFQQGLTPRNIIKSLVSLLKHIQNNALSAQHTEQIAFFLLRSFSLNNNFVNQLVYVCLNLLLPFDNSFVAINIIDKKEELGLRLLIKIVPEEMVGDFMKYVMECKDADLGMLCLLRLHRDMVLREMAKELGDERRPTSDQVRKASNSLVAYFGKLRAEFMRYHKVDTSRTVQHYHAILFDSIEKPFSSFYREGQDQRYSVIGRGMAGAQQARTTNNLRDHLNVKISGEICFTEALRKVSYMKDPVPFLSQAITNAGILLNSNDAVVRMSTLRSLDALSQNYARKVAVLNPSLIKINDDHSLRILLRTGDSNTIERIANTDLTQYDDEKALLIVKAFGTIAQKNGKEEEMARFLKPLMFKRSSLEMKKEIVRLYGELLGECMIDDECYINYEEQEEGTAVAGTTSPKNTKENDKTGGEERTIKSALNKNYVMDVLVDYLEDSQYSTITNDILGLIKDKKYLVAVYNRLILENEIVRNNAMACVNRLTGKSLFEENEDELLKYFFTNRKDVDVRKYVSNKKKESIFIKETRPVVLLHKEMKVVLVKRVFRCFVYVLLKMENTTKDLDIADGKMLMEAEEGKERYWNEKEFCKSAHYDEEYMKGDFQFMDCCAGQDDKRTDGVGKTTTVLFGIKAGFSTTVVMKRALVLNTEFSAVCFYDLTDPATEESENETRELRPFNVNYLDTIKPCSHGKTPLHSKKTSFALEGKSLGDAKEEVLDIFNLQVVDQVYADDVMQLVLEGVTIDGVCVRIDVRLESMSNDVGVFLKVFADSVEVIERIISVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ65</accession>
    <name>L7JZ65_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0967"/>
    <dbReference type="HOGENOM" id="CLU_1316225_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ65"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="23672" checksum="36A01DDF9CA2E76C" modified="2013-03-06" version="1">MKIFIIFDLKSLLSPTRMRILNPKAESLVANKHEVELNYLNNYHELNEDETFIHNDNPVGDNKTLKTTMPGTSNENNERQTSIMLNSVKKADNEHSAINLNESDDKKEKLSSGINPNNEKSNVQRNDFFVRMSNHDEKPLKNSSFLKNLPGAHFFTEPSENELYKSNLNWTSCEELDSNSAPNPNIAAKTVKNMLDAGIGKGIDVQRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ71</accession>
    <name>L7JZ71_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0972"/>
    <dbReference type="HOGENOM" id="CLU_138740_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ71"/>
    <dbReference type="OMA" id="QERNIYK"/>
    <dbReference type="OrthoDB" id="10354309at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="162" mass="19300" checksum="91793A54006C54CD" modified="2013-03-06" version="1">MKRIDRSTKIQRYHVSQNQRFIIKTQVDESRYVRMSSMCNDVIYLIALKVESNSPRLYGRNRLDQAVHSRMVRIARMKISKRKIEKHLGKRIPISLLKERNIYRNECCDYRKFYGIVESILKHKNNYYGTMVCNGFSSKLMPAAVKLHFFLRKRLLAAILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZB7</accession>
    <name>L7JZB7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0369"/>
    <dbReference type="HOGENOM" id="CLU_1533651_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZB7"/>
    <dbReference type="OrthoDB" id="10595400at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="175" mass="19941" checksum="8033E74BE24391EF" modified="2013-03-06" version="1">MKIGSTDNRTMLVTTRSARVLLNKMKTYNLIKIYSAYDVSSIIATDLLITVLEKECIKYELAVCETVEKINCEEESILHIYVDLYPRKDLGGLYIGLAVKKKLLKWNRGHESNKSGRADEDASEIEGNRAGRREFCRRIPLMKLILTEVTDAPMMLLFYPVNTTSADVMMTHTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZC4</accession>
    <name>L7JZC4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0213"/>
    <dbReference type="HOGENOM" id="CLU_2544214_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZC4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979271" description="Transposable element encoded protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9411" checksum="F064FDC89AFC4600" modified="2013-03-06" version="1">MHINHAFLHCIVCFDALCISRTHSMPISFGAILPLIFPFSPIYSLFSVQSTYRCTYNQTFPCMAYHVSCASNKSKGRRESPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZG7</accession>
    <name>L7JZG7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0411"/>
    <dbReference type="HOGENOM" id="CLU_2279412_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZG7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="102" mass="12175" checksum="FEC5F81D9892A4DC" modified="2013-03-06" version="1">MKNKDILFSACCRCPNDENIAMYIPEKNWAMILWILHPFMVYRMKIWNAIDIKGYTTTDIYADMSCTKLINDLECVRMNRSYKNQRDGAEYYQMNILQQVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZH0</accession>
    <name>L7JZH0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZH0"/>
    <dbReference type="STRING" id="72359.L7JZH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0183"/>
    <dbReference type="HOGENOM" id="CLU_088696_2_1_1"/>
    <dbReference type="InParanoid" id="L7JZH0"/>
    <dbReference type="OMA" id="LNQACNP"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000061">
        <property type="entry name" value="TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="8">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="16159" checksum="3DA4021D89F0128A" modified="2013-03-06" version="1">MSTNPPTKSPPPDPDNQPDHSSTTSSHTDTSTGPSQTVQLLQIVDQMTEPQLHRYESFRRSGFLKVNIKKLVNNVLNQACNPNFIIAVSGVAKVFVGEMVCKAKEVQDRWGDSGPLMPAHVHEAYRLLYRDMPNMKVYKRFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZL7</accession>
    <name>L7JZL7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitinyl hydrolase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993818">
        <property type="protein sequence ID" value="ELQ76750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0259"/>
    <dbReference type="HOGENOM" id="CLU_2612700_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZL7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9000" checksum="01D5631A4816BDC0" modified="2013-03-06" version="1" fragment="single">VSFVSGTTLDPDQLIHAGSKDYEFKSAVFFYSIGSTGHYFTVCKYESKFHIISFGKSNKANFNDVCVKNRLVLAFYEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZY9</accession>
    <name>L7JZY9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0327"/>
    <dbReference type="HOGENOM" id="CLU_1769486_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZY9"/>
    <dbReference type="OMA" id="CWIHDED"/>
    <dbReference type="OrthoDB" id="10366473at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="150" mass="17187" checksum="B663D6B7A5551B6B" modified="2013-03-06" version="1">MAINIIFGIVLFNSAVLFLVGEYSRSKMERILQNDKLSFSSLFPVQWKNARIGAAEERENEAVLSNILASGGKRAYSSLVEEIHKLDRDSRKTERAGKNVFNLTCWIHDEDNCTSNRKKKTESNKSVMLGPNLTVEREKHYAYLNRKFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7K003</accession>
    <name>L7K003_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K003"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0659"/>
    <dbReference type="HOGENOM" id="CLU_2575550_0_0_1"/>
    <dbReference type="InParanoid" id="L7K003"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="9511" checksum="364ED2AC8FEC0441" modified="2013-03-06" version="1">MQKGASQNAGELLDDDYRDVKLKLESIYNRREQIKDLEYVSSLLKKQKVLNKRIDRLISAAKIFRGKVQLKEGHIYEVDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K029</accession>
    <name>L7K029_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993850">
        <property type="protein sequence ID" value="ELQ76402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K029"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0615"/>
    <dbReference type="HOGENOM" id="CLU_2225033_0_0_1"/>
    <dbReference type="InParanoid" id="L7K029"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="106" mass="12385" checksum="59F4A15BA8923C22" modified="2013-03-06" version="1">MVFDKSVSSEYLSKIISALSMFSSSFLHASLTMVFSKHLFEAVSHKETVTIPDIRDKKPLRYFKPMNYIYFLRYACLAIFVFLLLVIIFYLPVLSPKTRLRQYGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7K042</accession>
    <name>L7K042_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthase</fullName>
            <ecNumber evidence="5">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.3.5.4" evidence="5"/>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K042"/>
    <dbReference type="FunCoup" id="L7K042">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K042"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0012"/>
    <dbReference type="HOGENOM" id="CLU_012368_1_0_1"/>
    <dbReference type="InParanoid" id="L7K042"/>
    <dbReference type="OMA" id="NIGLCHY"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="109"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="267"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="359" mass="41392" checksum="3D16D0C8993ACB78" modified="2013-03-06" version="1" fragment="single">VAICFYSDNSIYFFKDDVGRKSFGFTITNMFYAGSIGFETEVDPNFLYQYRIRDHKLLCVPKDKSITCQIGVEYHQDRISHNIILLKQEEIHVKWRKSEDLKSQAHILENLLIQSCKRRTHRFDNVLFFGGGIDSLIIAITLNKVVEKNRPIYLVNTSFDGEMSWDRFYGLKNYHALCNILKERKYVFVRNDISLEEVKRALPIVKKLIYPKISIMDLNIGLCHYFSAKKAQNYTKVVYTGMGADELFGGYSKYSKKTTSARCAIDRDVAAIYKDNIGRDDRVVADNAVEMRSPFLDKDVIKFALSLDVKYLVNTGDKGCSKAILRELLTLQGFKTESKINKKAVQFGSGLKKMEKEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0E2</accession>
    <name>L7K0E2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0E2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0356"/>
    <dbReference type="HOGENOM" id="CLU_395467_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0E2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="697" mass="79340" checksum="FC3975ED14C0A470" modified="2013-03-06" version="1">MYLQTLKNCFISFCRLFVILSHRTMPGIMRTCMAQPPEQSVTNVDKESAMSSASGMDDNDNNGNGSASVRPKYQDIKGADAKNQSPANDNNQEESISASSAYQEVANEHQAQIPDPQSEIYFFQRGILLTASRILLLDSLNEVFDIDNISPQNLAKLSKIYLDCKMICEKEPFNRASYDINLTQFLINKYQQSQDADFNLLSLEQVSGDIIRLEPFFIFVKACYAIPEDKILQEANKRLKIIEEDHSVAIKPYHEILLCYLDYTKDYVNKLREKFRNLCDEQPLMEKLHEFEKQNRGSAKQKVNMETSEDIRKESSKEDEQQQGIQHKSDNLNNFEAHPTDIPIVSVTEVSTEKNDEQPKEKNASQSISRPQDKNHHHDEQIIQNDTSESFDNDTKKIESTTDDNASSDLHTNTAKTDALESYDSGTDAKNEGDNVAAKRAAVKYRHKRIPNYQEFLNDLRDIIPFIDELGEDSAVADKSPFDDTESSVRSVDTLKVPPRHGAKNGRDSDSDSRYYSASDNVEHGYGDDIDDEQLYRTDQPAVNMPETDEYSLQNNNFPPGHDEPFTLDNFYTSEDHRPQLEQQSIADEPPYEKHDAYEPSGKDNGAKIRFRNDQRSNDNSNHHHEARGHKTQHKNQKKNTTDKSSTTDQDKTSQSNGSTKATKSNSKKNYNTILFLTITTVICLVVGVIVYLIIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0E4</accession>
    <name>L7K0E4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dephospho-CoA kinase-like protein</fullName>
            <ecNumber evidence="4">2.7.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.1.24" evidence="4"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0E4"/>
    <dbReference type="FunCoup" id="L7K0E4">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0E4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0361"/>
    <dbReference type="HOGENOM" id="CLU_057180_3_1_1"/>
    <dbReference type="InParanoid" id="L7K0E4"/>
    <dbReference type="OMA" id="DVDKEYH"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="213" mass="24866" checksum="D6684A38DA8CB10B" modified="2013-03-06" version="1">MYIVGITGNIGTGKSLVGSLLRQKGYCVVDADKISREVLEHNKELLRRNFPELFVNNQFSKAKLKEIIFKKEKNKKAIERILHYKITVKMCYIVLMEALKFKRVVFLEIPLFFEYNLDRFFDSIVVYCDKSTQAERITGRDGNSLLNEKLKAQKTMEEKKKRGTFLIDNGGSVEYTKMQINNLKFSGYTIYFYFTVAVLTCYLAKYLLKNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0G9</accession>
    <name>L7K0G9_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0G9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0433"/>
    <dbReference type="HOGENOM" id="CLU_1817150_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0G9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="16082" checksum="F0179EB207397041" modified="2013-03-06" version="1">MIKQKQLQNQHLQKQASQRRKIKSISAEDELSKKLLPFFGGILEKISKDLIVKEKQGKRRHTTTSIEKKTNIITVTSFKTITITKDAKKDADEGKKTVINTVYAKAKPKMIKCVPVMINNANCLITQEGVIVKTVFKENKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0I5</accession>
    <name>L7K0I5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ76792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0I5"/>
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    <dbReference type="HOGENOM" id="CLU_3210263_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0I5"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="45" mass="5102" checksum="18A2E643C2745C77" modified="2013-03-06" version="1" fragment="single">VALPNRHGVFTLRQESVMNSSSLCSCNLKRLFTNPNIQPRCPCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQT8</accession>
    <name>L7JQT8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative T-complex 10/CenJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3263"/>
    <dbReference type="HOGENOM" id="CLU_131641_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQT8"/>
    <dbReference type="OMA" id="KEIRMPD"/>
    <dbReference type="OrthoDB" id="10252174at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="115" mass="13662" checksum="428B584B8F07BF7F" modified="2013-03-06" version="1">MENKQKISLIKILKDEVAKLKELNQEYKRMINEKKVVHEEQSKGKTRYYLCDGSTYVVSADKKYRYLYDAKSRIITYEFDNGQVERTFPNGLKEIRYSDGSIAVRNGNKEYDYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQU7</accession>
    <name>L7JQU7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994101">
        <property type="protein sequence ID" value="ELQ73833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3255"/>
    <dbReference type="HOGENOM" id="CLU_1256827_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQU7"/>
    <dbReference type="OrthoDB" id="10689666at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="220" mass="25248" checksum="E64AA0D8F4415737" modified="2013-03-06" version="1" fragment="single">METSAGLVSVYLVSYLTHSENVRAERLRNRLNARIVEYQGRLNRHPMVSYIANSRPEYYVERAAGDTTSIASRFTLLEDKIRMFFAFLNGDDNIKALLQVLYFELYGCKTKLASNTVVDLYKKLDTVMNFEFADYTFCDMNWSIMPVDSAAIVESLLYFGQIPSFVNPKSGKYEMFFSSRAVGANYEIEDVYREQVFGHWLGTKKINCYNGIVPMLVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQW4</accession>
    <name>L7JQW4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3233"/>
    <dbReference type="HOGENOM" id="CLU_3242460_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQW4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="43" mass="5208" checksum="880B1BC5D67C7462" modified="2013-03-06" version="1">MNSTTHQRFIGTYVMYPEVVLHKLYGHEQRNSPEIHWHIRDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR44</accession>
    <name>L7JR44_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3139"/>
    <dbReference type="HOGENOM" id="CLU_2559919_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR44"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021494">
        <property type="entry name" value="DUF3149"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11346">
        <property type="entry name" value="DUF3149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="82" mass="9717" checksum="2377DC9B429C9D87" modified="2013-03-06" version="1">MALDEVLKDFFTNVYGWISIIFILIVILMIVYIVKALVDDSDNRPRDSQGNVIVVNQQMANMQQEKSKREEREREKKEKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRB7</accession>
    <name>L7JRB7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3260"/>
    <dbReference type="HOGENOM" id="CLU_3144016_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRB7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5678" checksum="73E085616AF6C05E" modified="2013-03-06" version="1">MSIDKAFEDLLDEIDECEFALRALERKAKPLTQFVYTAAAAYKEEEHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRM6</accession>
    <name>L7JRM6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2980"/>
    <dbReference type="HOGENOM" id="CLU_004199_1_0_1"/>
    <dbReference type="InParanoid" id="L7JRM6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="798" mass="92221" checksum="4F8CCFBCB2489451" modified="2013-03-06" version="1">MILKGNIVISVNISEAAFLNVTLDETSLITFEKECASLDLDMFTGQLNAPNVTAFNKLEVNDVKNDLLLSSLLSIPAKNYTGTRMVLDNVTFYCKVEQTKLRSYIESDANNTIRTLEASNRENPDVDFNKIGINTTNLVKQIESTVLPCIKDGKIRLLILKGQKNCTTLSFDDVKVKQTCIIEESIQILVINKYSSENNAVLCVSKGLKYLHVTYSETNIDISQASDLKALRLVHSQLTYDRKVYMNLTYLNIEDVVLNQDISLGSNLKTLKLDKVTVNEPFIFKINSNVSYLSINRSTGMLDLSGLIGLNHIRIDSKYKLIIDRSSLSRDKYSLYLEKFYLNRNILVLDNMEEVRMKNVEIRETCTLKIGKECKFLEVVACKVNIDMSEAHNLSNLVLIDMPFRFLKRIGNIPSITTLTLQNITLETDYVCSHHLKIIILRSIRTIENARFHVNEKCTAIHLYRCSGAFDLSKVEKLEKLVLIPLLGLPNIRIMYLSFDSIRELELAYNFHETEFMYLLYKCIHLVRLTLHCLCYDEAEERKILLNSWLKKIQDVSKYDLWASKKECLRYSSELLYMDWARADLLGTKMNMLMNESFTFNVQHRLKYLRLVAFNFDKRNLMLLPNFDSLQTLIVDYRFCDSDFFAYLPDSLETLELINDKGYDCLERTRPSFSSTALECLKKHPNLQILKIDDPLYIGGHLFDFLPTKLQVLRFTFFLSVGLKPREIVKRIKLKKLILYTDDYSAEIIIDCKNPFERQCPELFGFLSEYIDFQALDELILEVDGKGISLDKETYQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRN1</accession>
    <name>L7JRN1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2985"/>
    <dbReference type="HOGENOM" id="CLU_2905767_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRN1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7266" checksum="DE6E64F127C89ED9" modified="2013-03-06" version="1">MVIFNIRVPIFCIYILKILISEVCYWLESGAEISNREVTSDVECYVTDVVFWFYSAFTPFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRT5</accession>
    <name>L7JRT5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRT5"/>
    <dbReference type="STRING" id="72359.L7JRT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2923"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_2_1"/>
    <dbReference type="InParanoid" id="L7JRT5"/>
    <dbReference type="OMA" id="ATHNYFL"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="343" mass="40154" checksum="B839E4D498B4E157" modified="2013-03-06" version="1">MIYGELIVGLPGSGKTTYLKYKKNYLAGRNVYTVNLDPGRWEKERHVNNKDTYNNNVMDKTTNLEREKQSDGNNVMDKTANLEREKKSDGKNSDKTANPKPDHPKTANSKENAEPSVNNFTFDYDITNKYDTRKYMKQREIGPNLAVKKIMEEYVANYEEIRNIFCNEECYYLIDTPGQIESILNFDRLLLRLQRDGIRLVTVFLSDINSMTSIESLSYTYFMTMQTMVTLNHSQINVFTKLDLLDKIRLIDKLSNLIELALNVEEYPVLFKVLYRFIERESLIEYQVMEYREDVLCYLQFCIDQASGFINEIEDENTLAEYLSGIKEKEEIIRSYEEKEGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRU3</accession>
    <name>L7JRU3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994086">
        <property type="protein sequence ID" value="ELQ74020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3071"/>
    <dbReference type="HOGENOM" id="CLU_1278424_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRU3"/>
    <dbReference type="OMA" id="TGVQWLN"/>
    <dbReference type="OrthoDB" id="10393420at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="216" mass="24813" checksum="DE0FB0E50F58D748" modified="2013-03-06" version="1">MSVKDLIKFFEAMSAEEPTIRGVLPVSNNLKRLENNEPAVATKHATAKKQNKTAEKPKNEQLLDINKYARKVPTPHLTGVQWLNLRGFAHKIKMKRVAERNKREGKPPPDPHENESGFDKFVRGLQERIRQKGREPKTVLRNRCCDDTYSDLDALVREANSVEGVEKKQTRPKNFDGFSKQTNCTLIKEPFMYKYLRKISRIISNVLGCCNDTFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRV3</accession>
    <name>L7JRV3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2928"/>
    <dbReference type="HOGENOM" id="CLU_2518849_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRV3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="9655" checksum="586441669D28AB25" modified="2013-03-06" version="1" fragment="single">VPGVLLKDVIDRVFTSYAVFDRLKVNATHCLGNVCVLKAYTAFEEENGLLIITVPLFGTTPDEENDRLTHYTLYCIKGVFYYYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRV7</accession>
    <name>L7JRV7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3063"/>
    <dbReference type="HOGENOM" id="CLU_2127100_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRV7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="114" mass="13865" checksum="F0B8AD0716F914B5" modified="2013-03-06" version="1" fragment="single">VNLKSLRLNGKLFCTNNVFAFLPENLQTLKVAWFHLKDAQKVEISTKRITLQRFVLCVRVDNRHVFFDRDPFKRQHHFLFDYFRRFINFEDLKELIIEVDGEEIDLDTETYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRZ8</accession>
    <name>L7JRZ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2850"/>
    <dbReference type="HOGENOM" id="CLU_3015879_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRZ8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6240" checksum="30382390C88C8238" modified="2013-03-06" version="1">MRGNNMHSPARSSSHASPYNPMTNPYLRQNSFDPFATTETSPGLDTSMPYYISSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSB6</accession>
    <name>L7JSB6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3142"/>
    <dbReference type="HOGENOM" id="CLU_740074_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSB6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013152969" evidence="2">
        <location>
            <begin position="16"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="374" mass="43061" checksum="408879A6A3EE0E39" modified="2013-03-06" version="1">MQFLKLFLTVCAVCCTFVPEGRRGMKSEDGKVGDEKKAIVTSVSMQPRLNELGELLLNKLFRTADNICKNFVNHVIPRMKQEDWNTLKATRVAEDSSTSLIEKLGFRTLNFDVMRTYIHGTKSITRCDLLQIMFTYILYGVDYCFSLQWQAISLKKYFSKIPSANFISLEIDGSDFCHKLEKLFKEANSTIPNNQQTELETWFEEIIMKRPKKVYDFLMKYDDVLEKDDVDYIRVLLILKGVSLDIPKGATIEELVSIIKTNQWQRLSPNNEDTTTKKPKTVKKYIHLVLNGGAKIKDLISIIKTNQWQRFSPNNKDTTTTKPKTPTELIIRAGSEGIINIKDMFEMLKIIKEPGPNNEDTTTTNPETSTKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSE2</accession>
    <name>L7JSE2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSE2"/>
    <dbReference type="STRING" id="72359.L7JSE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2701"/>
    <dbReference type="HOGENOM" id="CLU_021169_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSE2"/>
    <dbReference type="OMA" id="EMIVKYE"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="598" mass="70292" checksum="60126C5ECD878A66" modified="2013-03-06" version="1">MAKNKFVPLVLQPIKIENYALLITKLKMMSNKYKNCCRSTKFIDEVFSLGDINLKKCLLRKKSVKEEKIDLREIINGYFEHTVRMKNDILLKDGVRRAKAHISNLVKKLKEEDKMKKGILHKIQVRDSMYIEVNFDRSARVDFSNPFLKYAFDFFTQHVEIDETYKRKEVFSKEINFLEKSYYDHVQKVLLENNKDNSVEDYVKIKYPKEEYFIESYDGRYLFAEVYTYVRCGFVQKALELIDTFSVFFEQMAPSLRESIVAFFNNNYVNKLEFEKARSIKNDRFKLMLYQLVCNVEEAENLLENFEDFLWFRMLQARSVNDILMLNKSLDVDGCKLLVLIFCKKYGTAMRVLYAGDFSIIEIFYVMRELCKVKKDISLYAEIVFTLLKGFKSLDRKLKLVNSLHAFNDYESLVAEMIVKYEAYDLLGLKSEVCYLDKTVVDRVAAILSKRNDRTRLLQLYYLFNDDVNIVGILNEYLIDHILRGKKELFNYTEIIAFYSQRSKSRETEKMKILKGLADFKDKKDIAALRNSGIFTDAQPSLLMEIKPVIEKLVPLIVSVIEEKKESVMAKELFELCSSISLGERCTVYVGEKLVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSN8</accession>
    <name>L7JSN8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vesicle coat complex COPII, subunit SFB3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSN8"/>
    <dbReference type="STRING" id="72359.L7JSN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2753"/>
    <dbReference type="HOGENOM" id="CLU_026726_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSN8"/>
    <dbReference type="OMA" id="EYICEDS"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF36">
        <property type="entry name" value="TYPE A VON WILLEBRAND FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="753" mass="86327" checksum="3D471E1FA3445E43" modified="2013-03-06" version="1">MSTSKSSFPSTPKSKSSPINSPSLPEELFNDQHNTSKLPPLSTTDTLLQPLIRSTMSVVPNNTGLFERVGVPLMLVIQPRIMNVCVERESLVRCSQCTSYVCEYTKTEGSTFYCNICGAKNRTENEITDLENTLILEMGEEAIDVENELGEGEMTSKHFFNGRGKHSVLLLCLECTNATYYQQCVNALESIFTGDEPFNTATHVLFFVFSDTLRVPYLKNGVYYEKILLDNKIFLDTSVMVPIDRIDAHFMARLRAIRSKGKSVLALPLALIAHFSRLVEFTKVLLFTRENVMSESDYSTLIDDFMENRVVLNLFGVKGVVESPLNRIVVSTNGRSYLSRNDVMERNGLKSANSSYGGSVLSSKLGTSSTGLIGDLSKIRIGTNVHDNVAYNTESNDMSNDNSESNTPRNVYDTERDEAHRLIKNIRECVDETVMYDVKCEVKTSDYVRRNNIYANSAEEMAMSFPIVHMTDRCTISYTFYVDGMLEGPVYVQCVLYYRDISDFKKKALIMNLKLKTSDNYSSIYNHLSMDTIFAYYVKVMASEIGRMEENKKFVMGNLVRTLRTYRMSTQGSQENHLVLPESIKNLPVLVSALFKNRDFSTMVSLFKVRTISNWPVRDIVRYFYPRMFSLDAFYDKRDLKDIMCTRLQYEQLHDGEGYVIENGQVVFFYLLKMVEQKGDERELEELIASFVSEEKEMIENLKEQIDTYYGRELLVRFVRNDSEILGMMVEDRIGENKCYNEFLCEIHYKIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JST4</accession>
    <name>L7JST4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin complex component, TCP-1 beta subunit (CCT2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JST4"/>
    <dbReference type="FunCoup" id="L7JST4">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JST4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2450"/>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="InParanoid" id="L7JST4"/>
    <dbReference type="OMA" id="RKMDIEH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="374" mass="41509" checksum="B2E088E5FB657554" modified="2013-03-06" version="1">MQNHLDAGATEQRSSEARKTIVIGTSMINTLIKSTLGPFGLTKLLTCDDKIKVTNDGATLLKNLVIDSASARILINASVSQDWEEGDGTTTIAILASLLVEEASKLEEIHPIQIIKGYEMALARALEVLDGVCFVMKDDDMVTLAKTTLNSKILRCDLQRFAEICVNAINLIEERDDLSLINVIKTEGELQHSYLVDGFILDKDVVVPTLKNPRILVANTSMDTDKIKINGAQVNVRSVGELSQIEDAERQRMQEKVEKIVGAENGIDVFVNRQIIYDYFLQLFREKNVVAVEHADFEGVERLANVLGAKIMSTFDSLNDCIGGCERMENVHVGEKVMVKFSGLRKARARSFSKDPPLRSLMRQNAACTMRFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSU3</accession>
    <name>L7JSU3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 3-ketosphinganine reductase</fullName>
            <ecNumber evidence="3">1.1.1.102</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.1.1.102" evidence="3"/>
    <dbReference type="EMBL" id="JH994075">
        <property type="protein sequence ID" value="ELQ74111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSU3"/>
    <dbReference type="STRING" id="72359.L7JSU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2974"/>
    <dbReference type="HOGENOM" id="CLU_010194_3_0_1"/>
    <dbReference type="InParanoid" id="L7JSU3"/>
    <dbReference type="OMA" id="PRQWGFF"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="369" mass="41815" checksum="2D52531D9EB3F683" modified="2013-03-06" version="1" fragment="single">VHEMLSLILLSLLCTFALVVLSNYKRPRKYQNKNILIIGGTSGLGLSLALKLSNHNNVSVTGRRTFDTAYLPLRFIRMDIMQGCIELAEYDAVFYCAGYAVAKYFVDLEWEEIVNDFSVNYFGAVRVLRMLAGCGKRDGEEKVMKRDQNGSASHRNDRADCDGEEKVVKRDQNGSASHRNDQAGYDEHSTSCTTALSTSPFRAALRVMHRGSAITNNRSQRTIKPRDIVLIGTPLAFFAVPGYAAYSPSKSALYNLFLTIQPELRKLNIYLYFYIMSTTKTPGYDRENITKPAFTKRIETWTEETGVDERSDRLLDGMAGCSVVTSDWLVEIMRGNMECGVKGVVMGWIGSIIFLFYRRYMNYLFMHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSW6</accession>
    <name>L7JSW6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolases or acyltransferases (Alpha/beta hydrolase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994072">
        <property type="protein sequence ID" value="ELQ74131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSW6"/>
    <dbReference type="FunCoup" id="L7JSW6">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2959"/>
    <dbReference type="HOGENOM" id="CLU_049633_4_0_1"/>
    <dbReference type="InParanoid" id="L7JSW6"/>
    <dbReference type="OMA" id="DYNYYTI"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="287" mass="32378" checksum="0F8D608845976FAD" modified="2013-03-06" version="1" fragment="single">VINVLNCTPMHVNLSVYDESNHLLILSTTQTVNTEVIILYIGGMLSGLMHPKFVFEMADKMDFAQFAQPMLRSHPFFGLWSLSDDAKDIEKAITYICTSFQDKCNRSTTAEAENDINIERDKKPKIILLGHSTGCQSILHYLNTHKSFTKITCSILLGPVSDREYEEHTNPNLQHNLELAMENSKTTFLHSNCPVNAQRYISLFSKYGDDDLFSSDLSDEFFKTINKSGTPLHFLLLKDDEYVINSNADVLKMVNNADVRVIDGDHMLSGGVDGLISVLKEIIQIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT03</accession>
    <name>L7JT03_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3252"/>
    <dbReference type="HOGENOM" id="CLU_1469217_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT03"/>
    <dbReference type="OrthoDB" id="1631570at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="184" mass="21924" checksum="37D2E04100337E6E" modified="2013-03-06" version="1">MHNERSFMNEPSFTHTINSRTTQNLCLSRAMIPYKTNTSFKDHLRSSALHSNVNPDLTIFQGNMHLFPYVFSASNIFTFSYTNQITIFHYLGKIFYSKPSYKDHNYFDNKTVIKFLFENYLLFYDYDDAFCDDLSLLYARHCYELITHMAYHIKNRRAGQFISFKPPCQSPIHLHYKNEFEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT12</accession>
    <name>L7JT12_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major Facilitator Superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3170"/>
    <dbReference type="HOGENOM" id="CLU_054257_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT12"/>
    <dbReference type="OMA" id="YEMHHIR"/>
    <dbReference type="OrthoDB" id="10366299at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978819" evidence="6">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="40"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ73892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="439" mass="50402" checksum="9699B1809375A751" modified="2013-03-06" version="1">MHRNFILFNLFAFLFHSCYATMHHFWFHIAGECKHISVRLNSFVQILGCLSIPSAFVWSYLADRTKWHTRIIAINALFYVIASIINFNLRNMTNRYAVQCGCVLAILLRQISAGGTFSIFFALLLNYVKRTNSSNRNVGTAKMFGILGITFVMMMLGLSGYLFPSTNARNVALVICVLFGTFSAVLAFFSLPEFVKPEAVLFKRKISLKDLFKRVYQYMNLIVLAFFLTTVLIGLNRIALDNFSTSFYHLLGYEMHHIRLFFCFRMIIEAFALFHSDRLCKFIGLYNLFLLSAVFTVLRTFILTMFDLLRASKYRKIFLVCVVEAFKGVSTSAYFYSSTLIFRSFAKYDTQTLAQGLNGCAYNGVPSVLFSIISVFVTNPQSSKHSDVITVNEKMQYDYFLVFFQIVTVLSFFGIIITAVGIYLVKKNKLENFEWTAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT49</accession>
    <name>L7JT49_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vesicle coat complex COPII, subunit SEC13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_3128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT49"/>
    <dbReference type="STRING" id="72359.L7JT49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3128"/>
    <dbReference type="HOGENOM" id="CLU_032441_0_2_1"/>
    <dbReference type="InParanoid" id="L7JT49"/>
    <dbReference type="OMA" id="NEWTQSH"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ73932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="266" mass="29342" checksum="64B322A679956C64" modified="2013-03-06" version="1">MEVSTHPINSISINSAEDLAVTSSMDKKLRVFTLKDSNLRLQYELAGHESEVVKAIFVGGSDMIASADFAGNLFLWTLDNKKYALKQRIKVFEGAITSLTARLGRDVTVFCGCADGKIRAYKLTDTEYGATEIASNEYGVTCLSCNDEHLVSGGMDFKVNLYADSRLVETFADHENRVNDVAVCPSNKFGVFCFASCSDDKSVIIYTKESGGFKKQRIEIGEECYELCFSKTGFVLTVGYGKNSFKAFVPDENGNFTETEVEEIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT73</accession>
    <name>L7JT73_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Kelch-type beta propeller protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2550"/>
    <dbReference type="HOGENOM" id="CLU_399116_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT73"/>
    <dbReference type="OMA" id="KWEYIAN"/>
    <dbReference type="OrthoDB" id="10333738at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="690" mass="80417" checksum="3AD7A6AD7A9B1D0F" modified="2013-03-06" version="1">MSTAHNTIIIEMSFSNVIADPQNIVVIDHTLKYKKPMITLSFKPCMVTSLSVLDNKNVLNVKLKNRKISFKDKVYIYEIMDELKIKVGDIDKDVAREQKIAERPSDFFIGRNMRTNKEYASGTETAEDEDACEKDTTNDEDRFNTYGVFNVANNVSKDIFVEDNELPTNLLNNIVLSGIKLTESEIDAYYKSINVRCSKIIKKYLDYHKMDIEITYEDVILTNIRKLLKNGQIDEIEKILKNILENSSEMINNGPYEVQVHTTNSVDEPMCRQCFYVEDESCQKIILYDSSFKDLGIKASKHQENMSGDVNLATITNYYPMSGKLFCFTLRNKLYVVKERKIIKKLEIKELRWINNHKIAFHDKKILLVGGSRNLNGIDEYNTIIEIKLRDWPPNASGNAFDDNNDIYNLADVAETSDDYEICVNKDFYPRTKFDSHLYGDILIVIGGKYGKSRLNFIEYYHLKYKKVVNQVPFPLKSGDMRINSVIKNKTIFIIFSFGPKNLLYAFEIETFKWEYIANLGIDLRASLILGVEENECVGIMKKIRKNGEKETYKKCQVISLGMSNSENSLESNQPSVCTQACADEDVYTFYILKASKRYKVTVKRRKKSDLFDELIIKLRSYFFLLEYNLEYAQRKIFPLVQNNEKFYRMLMIKCYLEEKVSYNDIFEELSNFFVESMRMPKENIEDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTB0</accession>
    <name>L7JTB0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA and rRNA cytosine-C5-methylase (Nucleolar protein NOL1/NOP2)</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTB0"/>
    <dbReference type="FunCoup" id="L7JTB0">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2375"/>
    <dbReference type="HOGENOM" id="CLU_005316_7_0_1"/>
    <dbReference type="InParanoid" id="L7JTB0"/>
    <dbReference type="OMA" id="EPEENEF"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="305" mass="34406" checksum="DD7CD5E8F1DE0F49" modified="2013-03-06" version="1">MQSSCSPFFLEKIANMFNEEERAVFLEESEKKRPIVIRVNTLKATKKELAKNLLQRGMTVESLDFYSNCLTIYDSKVPVGATPEYLDGWYYIQGASSILAVMNLDVKEHMSVLDMCASPGGKSTFIAEMMKNTGMLYLVENNPERISSLSGNLLRMGVQNSVVINMNVLDLEIEKVDRVLLDAPCSGTGTISKDGHAKTLTEDDLKRYTEMQKKLILKGFDSLKGNGIMIYSTCSVLADENECVVEYLLRKRKNAKILECEGNVGKKGFTAFRGMFFDAKMKYARRIFPHVHNMDGFFFVKILKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTB1</accession>
    <name>L7JTB1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2815"/>
    <dbReference type="HOGENOM" id="CLU_839880_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTB1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978716" evidence="1">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="331" mass="39143" checksum="28B945E357C113AD" modified="2013-03-06" version="1">MGIYHLLLTFIFSLKIQLTSASNQPSTSTSLMLTEVTYEMTDRNSRTEFFNRYTYKYIEICYMYKEIKRILSVVDERHKILSTVFSINFFKTNVLEPNDCKLMFDCYVNFLIVLRDMKKTSAADEEFGKDRIQYWETNAKIYDIVAQFFSVLLFFIVSDRNSFEPMSDDQEFHDLSINMDAPDFEKEKGELMYADVKDMEKVDFMYKRLKDMVNDINNIIHSTGTVLWHNLSMLTKEAERFQNKSLHSGSTISYLKEELEFWKLEVRCGILKKNSHLWFNLFGATIQEITLQTPNPNVSESNNELVDNIYSRKQSEQSKKCKSKRRKNRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTC3</accession>
    <name>L7JTC3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_2797</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTC3"/>
    <dbReference type="FunCoup" id="L7JTC3">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2797"/>
    <dbReference type="HOGENOM" id="CLU_012393_2_0_1"/>
    <dbReference type="InParanoid" id="L7JTC3"/>
    <dbReference type="OMA" id="DQCDAFY"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="190"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="294"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="428"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ74291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="577" mass="65352" checksum="7FD5007D13C7458A" modified="2013-03-06" version="1">MLKPGTVEALYNNTKDSPLYDTPVVQLLSLKKIEGKSDKTVRYHITISDGKLYMKGIFSSQVSKEVGDIKVNTIIKISDFVILEKNGNCFIYIKGCEKIRDCERVGSPKNASSTEKVDSSVEMDSSKIKQSEKNTAKRAPDENNNKRVQVGDNNGKTAKESVTGTNNSTDDEKKAYTPIAALNPFQTKWIVKGTVQKKSEMREFKKKDGKFFSFELLDKTGNIKCVAFNDGADLFYGMIVEGSVVEISKAVVKMCNKKFANTSSDYEIHLEKNSVVSLLNEEGLSMSYDLCKISNLAGRVNKANCDVIGIVHEAFPVSVVLAKASQREIKKRDLVLADETGTVRATLWGDKSEIELDDHPVLLLKDVRVGEFNNAVVLSTAFGSAVKVDPEMDEAYALRGWYDEHKQSVVVERPQRNDYAFIEEIQGYGTCSATVLFIREDNLFYNACANNCNKKVSLTDEGYYCERCNQTREICNIRYLTTLHVADFTQQVWLNVFDDFCTEFFGMTAVELKKMGEENATQLQNYLKTLLYREYVIKMKRSEEVYNGEMRVRWRGLSIKKINYLDESVRMLRLMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTW1</accession>
    <name>L7JTW1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vigilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2220"/>
    <dbReference type="HOGENOM" id="CLU_261011_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTW1"/>
    <dbReference type="OMA" id="INCERTY"/>
    <dbReference type="OrthoDB" id="2196204at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="507"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="574"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1307" mass="147822" checksum="6EF8DC25B79A619A" modified="2013-03-06" version="1">MDALNKKFGVPDDYVFIIDIRSVNNTIINESVQDMRRALIENANVVCDRSTDSARMMISNISRSIRSNFFFYLSKGIRVFLDVEVPVCLFNYKKRLMDEIKKISEDTNVLIFLQIGNDQNKDMHCKAGVMGQGNLVDELYGKPVPLKRDNDNTGTYNEDGQYLGDKAKTGRFSVSPNCYCTRTCEVEGCEKDAYECEHYDRNGHTAESCPNYEYNEDSPYTLPLSNSESLFSDSSGNFEEDHSGNRNRNESEGVQRSIAQDKCLSPNYIESGNLNGPEPNAANEECTNTGPEKEQDAKEPATDLEATNRSFGTGSLQADSEITIQINGRWKESAIARLKILKFIENCFGNDLKFINCERTYFNLENKRRYYYGTRINYKLAITQNMSDKEIIARRNFDDVYFFEIDTVKLFYLFYYHKKQIEDVLCSYHSFFETSKINNTCTTVKLTGKNHKIVQKAIMGMTEDIFKVLITDVPYPIPDTFIFKTHERSMVIGKKPGIIELLKYRDMYCHVQIELSKELEEFLCGKKNGKINRIIKDTGTKINIMVNNVMTIYISGQSANVCVAIHAVENEFPEELAFHLSERHHKRIIGFGGKNIQRIMKKHGVYIKFMSEYERRQNNYSGNVVVKTPRKNREALEKMKNEILQLADEKEYKREIVQIRITLFEFFLFFIVRAVGYRMLFDEVILSFSRGTDTFLFKDYFFEVDRTPFENLLLESEKVGVDEVMCEVEAGAVSKACNGETRHCTGDDKGSIGTMSKACNGETRNYTGDDKGSIGTMSKACNGETRHCTGDDKGSVVNNNENRPASESREQSKEIHNEGVNDDGTAMAKCRNALEEHRHEQNEDKNTKPGVFTVESNMPDGTLSEPAGGDPKSFTSRCDKSTQNTELVNKDRNKTPHNRSAINNSSENVVEIIDPPVHKQNAEIGVASRCHSDTTVNNKPKETFEPGKCSQNADMRCFKETKFADDEMSTANEMPFRMGGTRIDTESVAFDGGFDRRRVGWEDGNRRYYEGSDVLVDDQQSVGEQAPTISSVVGVETADTPCSAGIAGTEITTKSDSSQRHISPSNADEDGNHGIVKNDSATGSDQEGGESRRYHDQGTPTSNKSNESSHTTATDVFIIDSHQHMQYVNDETMKMVNHINSIMPSTSNISTISLSGICTKSMIMDVNDVVGLNSAKKEFYFDILGQKEKHIKKISPFYYQIGKNYRCTYAFAHTITLKDGSLFLRSFQQIEQHQDGVNALVHISALRWYEERKLAFKIFHSQLFYSYENSLSESKIGDESGSSDSGPKIGSLLTVGFEKGKRQSSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTX5</accession>
    <name>L7JTX5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2181"/>
    <dbReference type="HOGENOM" id="CLU_1579612_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTX5"/>
    <dbReference type="OMA" id="HEEHIIF"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="169" mass="19938" checksum="1A7B4B816F8ABD2D" modified="2013-03-06" version="1">MLLNLSKYVDATFKFILIVKQGAENAHEEHIIFDNLEDTGLESYLNACYEEQALHSLVHDMKNLKSEHCCFGTNNDLNISSDCSSFYFNSFCGFEKIHYENYRDWLRNENTQYKVIRVPFTKLFLEKIIKLSEFHIPNFTSEEKNTIKEVLNYDNQKNKLLELIMQSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTX9</accession>
    <name>L7JTX9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2132"/>
    <dbReference type="HOGENOM" id="CLU_004199_2_0_1"/>
    <dbReference type="InParanoid" id="L7JTX9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1493" mass="169403" checksum="29C677DA98C17A18" modified="2013-03-06" version="1">MLDSAQCTNIVMKWILLFNDFGGGNNFLVCNNLLQTHLYDAICANSDVQSTNSGYFVKERYDLEIDPLGIAPQILREETKHDSNIDVEAITQDTVQCNYYIVRIPLSTSIYNKLIQLSLSSEFTAEDADVYNILRYVLLHWEEVRILTYKLCQLFLADIALKDRLETYHRESQAKRTCVNTDENDDENVDIFCALRNSMDKHIYYKLLDDRGDITVTANCTERITRLPLPVKLVDFSPPFSIHHLAMNYTFLSNNQAEIMRIRHTFSDDSMTIDLNFSKLVSDILHIQAQGLHPDMHFISTFCRLLTSNLFSDFAIAKLILRFSHSNLIFDLSFIVAGAVVIYAERCVFSGELLLPSTTRELNIFHSIINLNLQLCTHLKKLRMKEVQIGQGFRVLLNEGCQNIMLMNVRGTVVLSGSNIENVIEPGPIWTEFELHRNYADEMIDLKITNARITRDLSLGNNMVRVHLRNIKLENDVKLALGTNCKDTQIEQLEGQFQIYDSASLLIIYSGNRIAFIRLKEQQNTSTYDFSLLNGYFEHDMVIQPFLQSVYLRNIELGPNASIKVGEECTNFAVANLKGKVDFSGICNMQIIDCALTSDIRSNNESSFYNTLTLDRANHKIYMYNLKLDRSIHFSFGAENVMLQSVEVVHGCTVSVANTVNNLEIYNCKGVFHIPILNHVLSLDIQDCFVKITRNDDDSFDILLSKIQFVAPICLKDNIRSAYIRNVSGTCLQINGKCEHLYLEKCTLDVNYTYCMPFKSISLCSFISVAARLLSIPSIEMILEDLTVHKSVAISDRVKNITLSNVYISDGCILCLNSACDRISVDQCTGMLDIPVITEHSDTNCLVFDDAGALHFCTRLSGSVFELELRHVKIDHDIVLAENIKNVILSFVDVTEGNALVVGASCEQLIVKRCTGTIDITKSAKITALTLADTPMIYNKEVHRAVTYLCLEHMALSQTIVLGDSIRTLYVSKLITGRGKICVNVDCKALYVKHYSGMLLVPNVLSPLHLSYETTVELKQVGGRTSLSLANLRLSTSNALSDNVKALQLSGIATKNHVKLIIGRCCEVLDLDNCNAAIDVSSSNMLRTIILRNMNYNHLFEYSQIIGFDAIELYNMDVPFDLYFYGNRRIVSVSSVTLRQGRALVVNGEREEVKLEHCVGTFNMLNVRNLKKLVFVPATNGYCSVHFPNLTMLDDLTLSYNFDAANIEYLLSHSINITNLSFHSFDGLRSTRHKESFKHEIKSIIESFGPWVDYKQQAMAYCRNDGVFSTDDLISIVNLRMNAFANIIFNFRTCNTLERLCLKGFSLNEQNLKKLQTCTSLKFLSIEIHFVPNSFFRYLPHNLETLRISDECSFGFYDSSNEIACEISHKHLAQHNNLRTLIVSSILVILNDEYFKQLPTKLEYLEIGYFDVPEESHERRDTKAVLKQLVVVGAPLNCNHSIVEYSKHITRDHENMLDYLSLFIDFSSLVVLQLRIANTTIDIVPQSLIVRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTZ6</accession>
    <name>L7JTZ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTZ6"/>
    <dbReference type="FunCoup" id="L7JTZ6">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2885"/>
    <dbReference type="HOGENOM" id="CLU_083987_0_1_1"/>
    <dbReference type="InParanoid" id="L7JTZ6"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="18899" checksum="6687AAAC7AFB6143" modified="2013-03-06" version="1">MHKYSVPIEDPANTVHTNAKSLRIKFKNAREVSVHLKRLTLTRATAFLKNVINRKDCIKVTRYAKKCGRTAQAKKYERGSSRADSRGKWPVKPCQAFIGLISNLVTEAEKKGIEPDDLVIVHCQVNKAPQIYGRIQRAYGRVNPYNTKPCHVEMIAMRKPLVVADAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU47</accession>
    <name>L7JU47_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2133"/>
    <dbReference type="HOGENOM" id="CLU_2851316_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU47"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978748" description="Transposable element encoded protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7611" checksum="E4D5D905CBF93561" modified="2013-03-06" version="1">MLVYAFMLMLIMYFSAEKIYLKFISTKDGTCDILVLSSPCDGCLKYFYDMLQSIDIETVKKIKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU54</accession>
    <name>L7JU54_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NUC153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2489"/>
    <dbReference type="HOGENOM" id="CLU_1483081_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU54"/>
    <dbReference type="OMA" id="CYFMDEK"/>
    <dbReference type="OrthoDB" id="10341222at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUC153" evidence="4">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="184" mass="21619" checksum="F1C1D35995E53F2A" modified="2013-03-06" version="1" fragment="single">VQMMSDVVTKRIAVLSKGNIKNVKLEGVKSLISQNIPEDRLISISFRQKKKLAIIIELKDVQCSKTVYDILDGQEIENIFLDCYFMDEKAELGEEIFVEKVEKVRKTNTKKSERKKQRKEKTKREIEERIKRKNADGFVFDPNDSRFDKVYTDPSFYIDTSHPLYKNNEGAEMMVEEMRRRNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU87</accession>
    <name>L7JU87_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994000">
        <property type="protein sequence ID" value="ELQ74984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2082"/>
    <dbReference type="HOGENOM" id="CLU_1312819_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU87"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="210" mass="24572" checksum="4C27FB8395E9DB7B" modified="2013-03-06" version="1" fragment="single">VLPLRYVCRAMLIAPLPLIIFLYNRFCYALPFRMANFRDKIDTHFQIIMNEVGLDPVQMQYFIANLPIEKKMKMILSVSKRKAKTLMFIDFFGQLKNEACAEAFYCVKKTYEAGLEHMKMLNAANFLCDALVRGVFVSEYFELIVLFQKSGVSFPEKLYENVLVHVFMKNVRMKEFGSVHNLFFEWLEMNAKGDTLRLKAEMLRSKVLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUB7</accession>
    <name>L7JUB7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exosomal 3'-5' exoribonuclease complex subunit Rrp40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUB7"/>
    <dbReference type="FunCoup" id="L7JUB7">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2056"/>
    <dbReference type="HOGENOM" id="CLU_069847_5_2_1"/>
    <dbReference type="InParanoid" id="L7JUB7"/>
    <dbReference type="OMA" id="YICITGE"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="74"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="139" mass="15598" checksum="2ED42E65A3E5EF5E" modified="2013-03-06" version="1" fragment="single">VAIGKTVGIHPDYIKLDFGYAIKGILLAQAFLNSTKRNRPKVNIGDFLLCRIIRVGDVVFVSCCEEGLGVLEGGWVFEIEAWAVKTLFVRKNILSDIGRDYKYKVALGLNGMIWIDGKNVMVVKNVRDEINKRVKSLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUD2</accession>
    <name>L7JUD2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2009"/>
    <dbReference type="HOGENOM" id="CLU_120622_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUD2"/>
    <dbReference type="OMA" id="HPFSQHF"/>
    <dbReference type="OrthoDB" id="10370686at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="195" mass="22948" checksum="67EA700F074F7FB1" modified="2013-03-06" version="1">MVDSKFYVFIHCFISKRITKIVNTLNLLFSLDITITSFKICAAIFAPGMEFHVENGQFRIHNTNHNLLTLEITFDEEKEIKKPMNIPLLYPPPPSVISDVSQRTNIHVEVEHPFSQHFKFDHRFLVKYLLSLLYNKTVHLKVICFDEELKFDIFFETLRELLKRIDGTQVELFCDDTSKRIVIAGKVVYETKIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUF5</accession>
    <name>L7JUF5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Rad21/Rec8-like protein, Rad21/Rec8-like protein, eukaryotic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2685"/>
    <dbReference type="HOGENOM" id="CLU_1012609_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUF5"/>
    <dbReference type="OMA" id="YGEIRCK"/>
    <dbReference type="OrthoDB" id="10349118at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="1">
        <location>
            <begin position="223"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="275" mass="31617" checksum="810F108F791835FA" modified="2013-03-06" version="1">MHAPNLLILYKSRKLQRDRSIKINLSSLITRDYSMHDLFERAKIIFSISLIYGKQMRWIVDESKRIVEMFEVSGVKRVRRTTGTVRADQPLSNAADHEDAFGGSVHHHDAGSIIDHDVTYDVDHNDFTFPSEVEVGRAEHTEMEIKDYELKQPRYRRTQGCHALALKDAFIIQSITAKLRALEAHLPSEIELARNDVLPEYDYDGVNVSDFVEDNSVVEYEKDEFVFGEVVQGKPREEQADIFYGLLVNIEKGNVSVEQHECYGEIRCKKMAVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUK2</accession>
    <name>L7JUK2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1938"/>
    <dbReference type="HOGENOM" id="CLU_744307_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUK2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979157" evidence="2">
        <location>
            <begin position="27"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="372" mass="44614" checksum="FB839C8D66F0744E" modified="2013-03-06" version="1">MPMFRRMFMLSFLSYKLLLEISVLFADHSIEVARVRECHEDIRETKKSLMGMEGIEKDGIVLVVEQGGMNAVSGVEEEGVNVECEECRVEEKMSEEEEVDVECEECRIERREENERRVENERRVENERKVEAKTDEDKEVDVECEECRIERREENERREENERRAENERRVEEKTDEDKEVDVECEECRVERREENERRVENERRVENNETIQQQEAHGKTNEEEVKKINKAAKQGSAGKRTRIGRRKLNVVMKNRRNSRRKKGMQRRVRQLHKPRRRNTECSGNEGEKDMNRRRTIRFKTIAKRESEQQRRKRRIYNKAMQRRSFLSYADAVSNEDDTQQTGVVRQRSTWSIMESLFDSRIVKKCRKTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUP8</accession>
    <name>L7JUP8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1910"/>
    <dbReference type="HOGENOM" id="CLU_3191633_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUP8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5123" checksum="1BEF401D1EC6A7AB" modified="2013-03-06" version="1">MKRVIKELPVEESLKKIYMNHGPVAMACPSGLEECVELDEVCGCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUY3</accession>
    <name>L7JUY3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase essential for the initiation of DNA replication</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUY3"/>
    <dbReference type="STRING" id="72359.L7JUY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1954"/>
    <dbReference type="HOGENOM" id="CLU_110543_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUY3"/>
    <dbReference type="OMA" id="FCEICYQ"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="184" mass="21628" checksum="C20402B07A1F253F" modified="2013-03-06" version="1">MLKKYVIFSKPYILIEDIKGKHQPFYKEYDDDKVPCIDLRSPALCCPFLKNKRFKSTKRRKERKGGFCEICYQKYVSYDAHVRERSHREFALDSRNYKDIDDIIDSFAISNFDPDLYCPVSPLLRKSASLPIDLDEKGELMDWEAGKMLDTIVFTDMGGSDDEKDKLCKAVYKVENFINEYLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUZ2</accession>
    <name>L7JUZ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small nuclear ribonucleoprotein (SnRNP) LSM3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994014">
        <property type="protein sequence ID" value="ELQ74861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2200"/>
    <dbReference type="HOGENOM" id="CLU_076902_11_2_1"/>
    <dbReference type="InParanoid" id="L7JUZ2"/>
    <dbReference type="OMA" id="CIYLRDR"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7398" checksum="6511E954D6614BBC" modified="2013-03-06" version="1">MHPSMRDPLQLVKSYLEEKVCIYLRDRSKLEGVLCGFDEHMNVGLLVGDEFVTVRGDSIVMIGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV90</accession>
    <name>L7JV90_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.5.1.41" evidence="4"/>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV90"/>
    <dbReference type="STRING" id="72359.L7JV90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1730"/>
    <dbReference type="HOGENOM" id="CLU_1082481_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV90"/>
    <dbReference type="OMA" id="WNHPTEV"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="41"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="274" mass="31052" checksum="7A11DA6B9A05F1D9" modified="2013-03-06" version="1">MDLIKQSNKKYKKAQIIQPMFLFLSLLRSAAILPDKCVKAGMIALTFDEGPTGYTPAILEMLRDEDVKATFHFTIQNITRGNISEHMREAVEDGHTVGLRVNPTRNYDEMDSGEIKEDIEQQIKAIQNETETKIKFARAPVDAGETNADVYNALMEKKIIQSNYTYCLYYEVEDVDAAREYLNKVFNASNPKYDSFIFLLHEEREKDFPIMQDIITLGKKNGYKFVTMDECLNGYQPGTAVNSKASAQKLKRSSSASNTLTVPLSLLIFLLVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVC2</accession>
    <name>L7JVC2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA+-type ATPase</fullName>
            <ecNumber evidence="3">3.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVC2"/>
    <dbReference type="STRING" id="72359.L7JVC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2043"/>
    <dbReference type="HOGENOM" id="CLU_048761_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVC2"/>
    <dbReference type="OMA" id="RRFHTKI"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="141"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="415" mass="47608" checksum="05C08E8A39E44956" modified="2013-03-06" version="1">MDKAHIKTKRPDDKDLKTLYFVKSSRNEMLNRDITVDVLTYLVGYNLFQKPKDKKKGKGIFLKVIIIGAIIVCLIGVMYKIISKKKMQDAYKTINDPTVFSATNYFGKENIMETLVGRITRIINLIEKKNKKLLNSKMTAAKKNILLYGEPGTGKTLLVKKMAFLLDQNLKLLKLKKSKIDIQKMKKSDLLAKLKRMKPCVRLIAVQPSSLNDRYVGGTEKNIQKLWDFATKNKKHVITIVFMDEIDSFFSKRKEENSEHSSNVKSEFLCILDGLRSKLTDRLIFIGATNLPKTLDEAFLRRFHTKILFSKPSLDEIRLLIESFLTYNEYRLSDVEINELVNACNGLTQSQIARIFSDAADYSDTLTYYADFNDIMILLNNIKSAGNNIEAELAEIHVEPRGTEEDFVLYNNLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVH9</accession>
    <name>L7JVH9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin---protein ligase</fullName>
            <ecNumber evidence="4">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.3.2.19" evidence="4"/>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVH9"/>
    <dbReference type="STRING" id="72359.L7JVH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1628"/>
    <dbReference type="HOGENOM" id="CLU_1548702_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVH9"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="173" mass="20717" checksum="42EF82AB985D199C" modified="2013-03-06" version="1">MTILYAPTSKQFVKKTVYESLFFSKKRAYDIIHYFFYSLMPREFQEIYATQDIYYVLNGKEEITFNFLKSAFQYIKCSEGSKEVVFLLNIFKRKNEAYYRKFLKFVTGSENIPLQSNKLDLFKIYVEQIDVKNALFRASSCVKMLFIGCYDTEEEMERIMDFSIFNTEGFHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVJ0</accession>
    <name>L7JVJ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993972">
        <property type="protein sequence ID" value="ELQ75315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1742"/>
    <dbReference type="HOGENOM" id="CLU_3193992_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVJ0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5029" checksum="801804083ADD7F07" modified="2013-03-06" version="1" fragment="single">VTYKLSVFIGENHEFNEFLATDLRVGGAGETDVIVANLQFAELENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVJ7</accession>
    <name>L7JVJ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease P</fullName>
            <ecNumber evidence="1">3.1.26.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.26.5" evidence="1"/>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1549"/>
    <dbReference type="HOGENOM" id="CLU_1846639_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVJ7"/>
    <dbReference type="OMA" id="HYTAKLP"/>
    <dbReference type="OrthoDB" id="10371486at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="151" mass="16796" checksum="B305C42DD2F89B19" modified="2013-03-06" version="1">MISPSFTPFNPKMKKFNAVAHYTAKLPKAPSKPPILHLHSKKPVCTKLSSLPRRTITSHSVEALQHSFIRTVEQSYSVPGVLRTADLAGACLRVGMLSGTVIGESRTALLMECGGRCRIVGKKGRLFHFEWKGMKYFLVGDLMDSNRIVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW76</accession>
    <name>L7JW76_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1385"/>
    <dbReference type="HOGENOM" id="CLU_738074_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW76"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978851" evidence="2">
        <location>
            <begin position="17"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="375" mass="43032" checksum="EB34CEA31C5549B4" modified="2013-03-06" version="1">MHYISLVILFFEGVLGYRDAPGVIFGLKRRLICGGKQPKNGDQNEVYGERPSSLDNNELKRTYSLPSKPVEQRSTCEATSCTHGDRVTRFDDEINGIIRRIERPNNTNLPNGPLSQANYEGNNFNHEKRGNFPFVSYHGKESTYHNEGDINAQSGLYEVCTQTYPWIAYTKSERRPDHTPVNGAYICDDTKKDCETSSSVQKSSYNIFPEDNRPPVTNTMIHKTHTKGECINTSPCILPACKQCFDQKLKSFKDSTKNIRAKITNALKNVNEIKTKIVQQILSSKDKLIEINLNYGIHNMNPYNSIKEQYELYERMLFDALRDSDAWLSDLQNDLKRWQEITNFWINNLEKAIVDYNTFLNSNGCLNSLDIEQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWA3</accession>
    <name>L7JWA3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993929">
        <property type="protein sequence ID" value="ELQ75743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1301"/>
    <dbReference type="HOGENOM" id="CLU_2051302_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWA3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="13906" checksum="F17964A601E21478" modified="2013-03-06" version="1">MNSCCITLSRGVRPLLGMCIRSNDEYHVYEYYDSWLFAITKRVLACYNVDKIYIAEEQEMLCRAIEKYVIVKIARKYFEMECHGSLYGMLAHSILCNYSAVQGVSSDTLEKNVVKRAHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWF5</accession>
    <name>L7JWF5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWF5"/>
    <dbReference type="FunCoup" id="L7JWF5">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1678"/>
    <dbReference type="HOGENOM" id="CLU_075876_4_1_1"/>
    <dbReference type="InParanoid" id="L7JWF5"/>
    <dbReference type="OMA" id="NQCISAR"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="153" mass="17487" checksum="4B12FAC73E6F6BA5" modified="2013-03-06" version="1">MNREPELFESAVPECTEQFDPNKLTKGMVFELIRHIKDPEHPYSLEILNVVNLDSIEIKEISTTYGKNLQQVVVHFQPTIPHCSMAAIIGLCIFYVLKARLDTFWIRVQIAEDTHVNWKTINKQLDDKDRTNAAFENTSILNLIGDCIGPCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWH0</accession>
    <name>L7JWH0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+-independent Cl/HCO3 exchanger AE1, transporters (SLC4 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993920">
        <property type="protein sequence ID" value="ELQ75818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWH0"/>
    <dbReference type="STRING" id="72359.L7JWH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1223"/>
    <dbReference type="HOGENOM" id="CLU_091458_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWH0"/>
    <dbReference type="OMA" id="PIRIFAF"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="258" mass="28911" checksum="E07DA30B3ED0CDC9" modified="2013-03-06" version="1" fragment="single">VSSLMCQSKEYPLTKPAGFHWDFLLLGITTGVAGLIGIPPPNGLIPQAPLHTDSLVVYDKYGKKLSVVEQRLTNTLQGAMTFVMMSRPFLVLLGLVPQAVLSGLFFIMAVTGLHGNIVTNRIRYFFLDKEYIETDPACPQVWKDIHALPNKKWFYVYTILEVIGGVGEFVITLTIAAVGFPGVLLFLAFCAKWVWPLFIPREDLDRLDGDVADEFILKNFTVASDEKKRRKRIRMEDEENKYEGETEVGESIMASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWI2</accession>
    <name>L7JWI2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1205"/>
    <dbReference type="HOGENOM" id="CLU_3052057_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWI2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6420" checksum="541E5965519FA6EF" modified="2013-03-06" version="1">MKYWLHRLLHCEISAMQREATDWVINFMIQELNTCKNPRGEELLGVFLGVSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWJ5</accession>
    <name>L7JWJ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myosin class II heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1625"/>
    <dbReference type="HOGENOM" id="CLU_418330_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWJ5"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="7">
        <location>
            <begin position="286"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="656" mass="75953" checksum="AED29737C8F12740" modified="2013-03-06" version="1" fragment="single">VCGYYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPLRSFSSFFSSLAVDISLKTTTHKNLPPLSQKLSLFNYLPLPMNDSLFNERVPIQCSSDSISSILTCDITLTNDVLLTKLIDTNDIFKFYQCTITSTSYVHLKNEQELRVNFENFVRKVVELFYQVKNGRMKALFDKDSGRFIFVEQNEFRNIVRLELRFKVPDENDYKRYLADMISRMEVTNVKLKKDNVQLRESLRNVEEEMRTRVADLTDRNRLLDERVDKLKNRLEGVEKENEGLVAEREQLKRQIVEIEKQNATYKFEVEKNKIEEYKREQEMVRLKEVEECKNGLEKEIKVANDIIRKLREDVRRMNEGKEEMDENVQKLKNENGKLAKSNEEASKTVKEKEERIRGLKDALKRKDEKIKNLEMDKKQLVKKMEEAKFVYNHFYKKKEGEISSVSENQNSTFSVHPESPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWL4</accession>
    <name>L7JWL4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993921">
        <property type="protein sequence ID" value="ELQ75814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1227"/>
    <dbReference type="HOGENOM" id="CLU_2924355_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWL4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="7024" checksum="429355D6BB8F4AF2" modified="2013-03-06" version="1">MTRHFNFTKRICNQSRSQKIHPGLESILANANKPIILRDYQEDAAEAVLSKLPTVCENLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWL7</accession>
    <name>L7JWL7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWL7"/>
    <dbReference type="STRING" id="72359.L7JWL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1592"/>
    <dbReference type="HOGENOM" id="CLU_477500_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWL7"/>
    <dbReference type="OMA" id="MFRETYY"/>
    <dbReference type="OrthoDB" id="2194974at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031494">
        <property type="entry name" value="Beta_lactamase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17030">
        <property type="entry name" value="Beta_lactamase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="571" mass="66021" checksum="17F4413833E446A5" modified="2013-03-06" version="1">MPPLFLTAPRQYAMPAIKFTRCKENSFLSMDLHNDRIQFDYPAEIYGKNHRIGDKPILIKVKPVNAKKIFISSNNALGIFFMKKNVPIYITRPVYEQLVLRLRELQGYLVNYDDEHDKTDLRSVNDANITKAERNIIFITYNEITYFDTFMVEAVSSNTFLGWSNFILHVQNRKLAYVSTFSLKGRISFKMEPTKLHVIIYNQRQINTHGHNLDDFLRICQDDMIKIIPIDMSSMFLELFLFLLNTTRDMNIRICVVSSIYTAINRIVNGCGKWLNKKFRIEQHDPLPLIIKNVTYCDDLAGVNELDDDSIVFCTKEEFDVTNNSIDNGAYYGEMIGVLNKENGESTNGEKAQVTRAKVLNKENGKSTNGEKAQVTRAKEAVVDEDSPEDDVRIKRINTALGGADKNERIDFIIRSILKGDTTRAKGLFNRKYSVLNVMGYDMVSDYSFDLNLNSTVPEMRTFYGDPVIISNSGNGLKENDIAVTDEEVYVINVPNVDYYTYSIKNAERMSAGDNLLLFDGKIRNERLACTRNRLKRMFRETYYLYDGQYFFPGLRKKVWFDNDVFYIEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWN9</accession>
    <name>L7JWN9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993917">
        <property type="protein sequence ID" value="ELQ75844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1196"/>
    <dbReference type="HOGENOM" id="CLU_218125_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWN9"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5218" checksum="7D0E3CAD6336B071" modified="2013-03-06" version="1" fragment="single">VLEEMLDCVFSELYITSVHNFVLTLDLYMLKVVEEKIMELLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWR6</accession>
    <name>L7JWR6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993929">
        <property type="protein sequence ID" value="ELQ75740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1298"/>
    <dbReference type="HOGENOM" id="CLU_2043786_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWR6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="13725" checksum="E67F846D80BFE724" modified="2013-03-06" version="1" fragment="single">VQVDSELTSSDDEYDENVTAKRGTQECSWSANLEGVSTNHARCINENKSSTQTEDTRENIDTREDRCNQITHRRESVMSPRSNPKCNCCHVSILLVFLIVIVGLVLRFFAYSRRSTLPATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWS3</accession>
    <name>L7JWS3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993908">
        <property type="protein sequence ID" value="ELQ75879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1156"/>
    <dbReference type="HOGENOM" id="CLU_2910604_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWS3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7219" checksum="AD0530EADD3C5E7D" modified="2013-03-06" version="1" fragment="single">VKEFEGSVTAQNKFAEGDRVLKYSFSPILNKLDPHRVCGYIVTSKARIRGIYYRKERDRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWS7</accession>
    <name>L7JWS7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1904"/>
    <dbReference type="HOGENOM" id="CLU_696740_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWS7"/>
    <dbReference type="OMA" id="LFRCNTR"/>
    <dbReference type="OrthoDB" id="10376853at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="396" mass="46295" checksum="159D5398FF43B7E5" modified="2013-03-06" version="1">MDKKARRNVKKSVTDLHSDIDLKSHQDQNLIHNVLGYNTESKDLGVLYENYDADKEIEEEKTEYIEDEGFEEEYSEAEGTCSTISLEQELFGSSQVTSSSDEDQPAALWTDSESIEEHDLHYLKDREQDDLNVIYEEKKEAKIQNKLFRCNTRIIRMVANETYLIILDARGFLYKLEKDGQESFKLAKSFKMDKYFVVDIMVINEKLILISNKTGILKEIDLNTFEIEDIRTNIKRFERGFYVQGNIFLVNKDIVLFLNEKYQKRTIYHFENVLDIKFLEGKFYFLNSCGFFIVQDENIFKVSKKEYFSLTNILIHHDRLYLGTECGLKIGKKVKKYGAVKTIDAINDHVIVVTEDALRVLSDDHTRTWKIKIGCVVFFQNRIVFSDGKFLGALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWT7</accession>
    <name>L7JWT7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1914"/>
    <dbReference type="HOGENOM" id="CLU_458690_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWT7"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="595" mass="68579" checksum="06D77469FF59CA7C" modified="2013-03-06" version="1">MCIDEPTIIINEGCQHLFVSKCMCGISLVKSIFIEKLELSHCKKMIETNADQGKMLRVLRLIKNCIDPWMPIYGNIKKIYIHNNILIVQRANHLLIPSDCNNVILRNRIGTIDLSGFIFGALYTGMKTINFEYYFDNLERVHYLHFFSGSINIDSNFFGCNQKHKLLLENVKISGDSILLINEKCISIRVVNCTGSINIPKVLNKEDDLLLGLDVATRFYFIKQQSGKYYMRMCNVEIKETTVPNKKVEVVVLENIKSRNGAVILFDKSTNQFIMSNCDVPVHQQALGVNNNIIRLWTSNVCYRLLNGHIFRANKFSAKICRLSQTATRLIINGCQIDSGYRFGIDSSCKYVYITGYRGTFVLFRSLSEETINVQFNGDSRFIFIKKRFCQDYIMQLYECILKSTRKIEINVKHLILKNVPISNEYNQATTGNLQWSSFFKLDDLQSIVLINIEKFNFRKCVNLNYLRLESITINQNVSFSKSLKVLELINVTLTERGRLKLHRNLKKFYISGGTGENLSRQFFNTDITKSCDGKISSQRNAKSQEKLCCYLVSIDFQRSFYVPEETETLTLENIKMQEGQVLKINTNCKSLKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWY7</accession>
    <name>L7JWY7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase alpha-primase complex, polymerase-associated subunit B</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="JH993921">
        <property type="protein sequence ID" value="ELQ75815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWY7"/>
    <dbReference type="STRING" id="72359.L7JWY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1228"/>
    <dbReference type="HOGENOM" id="CLU_1723613_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWY7"/>
    <dbReference type="OMA" id="FTIMCIS"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="152" mass="16380" checksum="4B35350FA5333C89" modified="2013-03-06" version="1">MANFQTTDLRGDGHLFEQRRYYPIMPGSIAKTHEQDISELSNGAAGEKLTGVSVGGSSLETPYLGLTELGNSLPDVLILPSELKVFAKVVKGVVLINPGQFIRPSRSINTEDGTYALMSINAPDVNALNGNNVQQVDDNPDLFTIMCISVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX41</accession>
    <name>L7JX41_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative EKC/KEOPS complex, subunit Pcc1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ75999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0997"/>
    <dbReference type="HOGENOM" id="CLU_175759_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX41"/>
    <dbReference type="OMA" id="DHRDDSQ"/>
    <dbReference type="OrthoDB" id="10353159at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978847" evidence="2">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="107" mass="12633" checksum="275F1AE266D9DB58" modified="2013-03-06" version="1">MHMLKNVVIYLFFIPMLHLTLSHLTPVKMDFSSTFRIKHKDPHKIKRILEVDKDFRADSQTTYDIEDGKLLVNISCSNLVSLKKSAYDLFRKLTLVDETIKMIEEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX49</accession>
    <name>L7JX49_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993886">
        <property type="protein sequence ID" value="ELQ76048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0982"/>
    <dbReference type="HOGENOM" id="CLU_894831_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX49"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="311" mass="36549" checksum="70F2205EE777D066" modified="2013-03-06" version="1">MLDYTINASHEEENGISTTGNSFFSRSNYILNSFVFINGRSPFIYKIFLIFCEKDPRNIIFNLLVHPQILEDVAPDILELYSSRKSYDDICWFIELLKSKQIEITPEMFNCINYSENVDKMAVDMIELQDYRIYVFETCRCGAISRNVKEHLQIALATGEKLATERINVEMTFCLGKRAQHGDKSTVKDAAEKQQNVTQTHDNNRIKKTKCTCKSKTRFNGIIVKRKNHLIGVYEVFAPQDLFVFIKRSRSKNLLMLEKNIFWNVITYFLIYDLPINFKETCNEEFELVIEENNDKRYFNLLKLPQIKFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX92</accession>
    <name>L7JX92_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX92"/>
    <dbReference type="STRING" id="72359.L7JX92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1323"/>
    <dbReference type="HOGENOM" id="CLU_1670709_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX92"/>
    <dbReference type="OMA" id="CHDKELW"/>
    <dbReference type="OrthoDB" id="2191823at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="196" mass="22400" checksum="ED227B733BEA463C" modified="2013-03-06" version="1">MHVNYKRIINTHQKNTFPILAFPPKQSTPLTRTTLTPLMSIQCCTKQSRARITLLGPDTKGTNMIYTRLTKSTKGRNTHARHLETLTTLNSLKVSLCNVECHDKELWTLNMRFSDGVVFVVNVDDDKLDLDRLVVDRMERHVVLVMCNTRNIGDCVVDGVKDWGDRVKVAVCNVEEWKGVDEALRWMTDMLKGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXC5</accession>
    <name>L7JXC5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993877">
        <property type="protein sequence ID" value="ELQ76084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0947"/>
    <dbReference type="HOGENOM" id="CLU_2433028_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXC5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="91" mass="10451" checksum="CE055BDA0C063B45" modified="2013-03-06" version="1" fragment="single">VNFFLDPSQLANVPMSDSSTFFKPSTSNMNNYTIEFMCLEEDVGEDKMSEGLTHRNRKVRLYDNSKNYLNDELISVTNLIITIIMCLFTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXG4</accession>
    <name>L7JXG4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone acetyltransferase complex SAGA/ADA, subunit ADA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXG4"/>
    <dbReference type="FunCoup" id="L7JXG4">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1008"/>
    <dbReference type="HOGENOM" id="CLU_018273_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXG4"/>
    <dbReference type="OMA" id="CCIDICP"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="67"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="39359" checksum="5900BAF265235DB5" modified="2013-03-06" version="1">MTVTNFESSRKIIILCDCCFQEITNYTRIKCECGIDMCVLCYFHQKTAKNHTVTHRYYAIEPLNYTLIESSWTALEELIFFEMLIQHGLGNWTEIALNLKTKSSQEIESHFYKVFGININKEYDSDTIISEPSNPNYHYVSVYAPKRKDFDFEDEYEYEMNLKSLDVGENEIVKNFLLDAYKNLLVLRKYKRMIILEKGLTRVQEIKASKDGTDSGLFYKVAPLAQFISKKDFNLFLAGLSIEKYLLDYKGVNKRVKHDFFEIERLRMNILQPSERELCRRLKITYGSYMKLKRYAVLEQIRTKNVSVKALGRIVKGSDSRVGILHSFFKKNGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXK1</accession>
    <name>L7JXK1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_0846</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 13">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="JH993863">
        <property type="protein sequence ID" value="ELQ76173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXK1"/>
    <dbReference type="FunCoup" id="L7JXK1">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0846"/>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_1"/>
    <dbReference type="InParanoid" id="L7JXK1"/>
    <dbReference type="OMA" id="NIWFKAD"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000003">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="14">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="12">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ76173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="149" mass="16474" checksum="876B8241969B839E" modified="2013-03-06" version="1">MEQSLVLLKPDAIKRRLIGTIIAKYEQKGLYIHKLKLLKPSRELVREHYAEHKNKPFFTKVVDYLSASAVVAMVVAGDNAVAVVRKLNGVTNPVDAELGSIRGDYGMCVGRNVVHGSESVEAARREIGLWFGEDDGDVDTFDAAVVYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXQ5</accession>
    <name>L7JXQ5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXQ5"/>
    <dbReference type="STRING" id="72359.L7JXQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1208"/>
    <dbReference type="HOGENOM" id="CLU_021971_4_0_1"/>
    <dbReference type="InParanoid" id="L7JXQ5"/>
    <dbReference type="OMA" id="IMTERCI"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="43"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="212" mass="24798" checksum="EBD888DEB7476011" modified="2013-03-06" version="1" fragment="single">VYDIIKVPKSFNPKNRTDHRTYHYLLPQHIARLDSTALSSILALYTGTRNYHNFTQQSNTRGKSRHITNIRVERAHNGWYEIKITGQSFMMHQIRKMIGFVLLVINWGGEDGAVPAMERIRALFGCAFSERVLNVPKAPAHALFLDAPVFAGYNGRYENHRDLVVDEAEKAAVRERMIYKEIMTERCIRMFREWQECVEAHMYEYGYLKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXR0</accession>
    <name>L7JXR0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0804</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXR0"/>
    <dbReference type="STRING" id="72359.L7JXR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0804"/>
    <dbReference type="HOGENOM" id="CLU_076902_4_2_1"/>
    <dbReference type="InParanoid" id="L7JXR0"/>
    <dbReference type="OMA" id="ELEDRRF"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="9995" checksum="7290A51E26961EF5" modified="2013-03-06" version="1">MANSFKKFLKCNVKVELEDKRSFTGNLLAVDEFLNIVLNETVEQRKYKNKKGYEIRNLGLCIFRGSKVIGIKTVGDSEKNTKTGGIGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXT4</accession>
    <name>L7JXT4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0717"/>
    <dbReference type="HOGENOM" id="CLU_2270290_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXT4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="103" mass="11494" checksum="E1D8074B68DD892C" modified="2013-03-06" version="1" fragment="single">VIVQNEPGRRCTWECAANIHHLTKKVEELTQVVESLAKKSLVGDARLEHDEQHSAAKSQAVVRIMGQTPQAQPTPDTGKNFSKRELRTQSPGIREKMPILQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXT5</accession>
    <name>L7JXT5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993942">
        <property type="protein sequence ID" value="ELQ75567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1471"/>
    <dbReference type="HOGENOM" id="CLU_3322473_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXT5"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4408" checksum="00D1B144760C38AD" modified="2013-03-06" version="1" fragment="single">VAGLRPLALPTDVRGERPREEAIHPKPENRQTTFAAQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXV4</accession>
    <name>L7JXV4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXV4"/>
    <dbReference type="STRING" id="72359.L7JXV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0738"/>
    <dbReference type="HOGENOM" id="CLU_014831_1_0_1"/>
    <dbReference type="InParanoid" id="L7JXV4"/>
    <dbReference type="OMA" id="WNVFPGP"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="355" mass="40285" checksum="075A8B018DC06E6C" modified="2013-03-06" version="1">MDRFLNHPSDHSFSPTKHQALPTTLKEPFRTVHISNLADDFYSNHLDWHQNTLMFVCENKIKLMDFYSNRITDLKSFGSATVTCVKFGSDGKCAIVGTSNGNLHIIDMCTKKTSKFNVHRSRIGTVEPKDNVLVTGSRDRQIKCMDMRSKHISFAVEKHVQEVCGVRMNRSATLLASGGNDNKVFVMEMRNLKKEIKICAHRAAVKAIDWSKGSDWMMVSGGGTADKIIRIWNVYGITNDNNENSSHMHMKRAHGLQSTSTTDKMLVKAQSFNSQVCNVYWSSTNKILSTHGYSKNDARISNLSLRTTNVMCSHKNRVIHFAVNERLGCFVTGSADNKLCFWRMEDFEDIGMWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXX0</accession>
    <name>L7JXX0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXX0"/>
    <dbReference type="STRING" id="72359.L7JXX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0775"/>
    <dbReference type="HOGENOM" id="CLU_716102_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXX0"/>
    <dbReference type="OMA" id="FIRTYMA"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="397" mass="45330" checksum="F112986501E87C80" modified="2013-03-06" version="1">MDNLVIYAQTPFYLEMTLLYDLKTTFTSFIRTYMAIVPCFFRWSTGSILDRLKVLTILIVFTFLRSLNCSRMYHSLKVQSLVRLYVLFNVLELAEKLIGTLVNDIAKAIEERMEGTQEQEHTVLEDESVVLGKSNVRLGSEKSSNNKNVVLGKRNGSESEHEGINSGDDVNAVSERDKRTENESMTDRGSDVSLDDKVGVPSSNSQSMIANAVLMAVLTTFFIISTAIHTLVLYFQYLIIQLSLNSSSSVLYSLVISNQFLELKGNVTKKGDKAMLFSLVDHDGTKRFSLLIFVVIAFLSVCVESEKLTFTKFILPIIVVLLFKVLVDWIKHIFFCRYNNLNLSFYMCYKKEYVKGNNFVGLHILFMWMLYELTRMGYFSFLACFLACVHFVGLFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXY8</accession>
    <name>L7JXY8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0739"/>
    <dbReference type="HOGENOM" id="CLU_1590447_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXY8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="168" mass="20560" checksum="B8414667AAE3157B" modified="2013-03-06" version="1" fragment="single">VVFGVNRQRRNTRLNYNEAKKQYRRRIRNKHTYNQKVRRTLGLDKVKIADAKREKTKQLRYYTWSRKRPKQDRTIYEDENEPEKRKRKSVNASDNLVLMRIFNKKLIEMMNGAKLMIGKANKKLLMMLFSIQFLIDYYKVGNFRIIANYSRCWLGLKRSRKCYKIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY32</accession>
    <name>L7JY32_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993853">
        <property type="protein sequence ID" value="ELQ76378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0634"/>
    <dbReference type="HOGENOM" id="CLU_1563986_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY32"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="171" mass="20052" checksum="A316A1B57F79FAB3" modified="2013-03-06" version="1">MLNLTQYVNLERLEIEITVNNYDLFAKHVSMALKLKHLTLHVLGIDIDIIKILEINQTIKFLTIYGDDKHMIMANNMTGDVKSMCQRIKLINVNIRKFDLFKYVNKLRNIEKLDISKSVFNPKHFDDVKMFRSCRSQTLLVHVAYSDDFIELLVSNDKGFVKRSRFSVLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY47</accession>
    <name>L7JY47_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTPase Rab5/YPT51, small G protein superfamily GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY47"/>
    <dbReference type="FunCoup" id="L7JY47">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0781"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="L7JY47"/>
    <dbReference type="OMA" id="GGPNKTC"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="198" mass="23133" checksum="D0094DAB4482F942" modified="2013-03-06" version="1">MALVLNERKEYTYKMVVLGYYSVGKSSLIQKYVKDEFNPNEESTIGAAFLTKTSIYPNYNIKYEIWDTAGQERYNSLIPMYYRGAHVALIMYDITCPESFETAKNWVTELSSEKPKNFVKVLIGNKSDLENTSRKVDFEEAKEYARRNKMLFFEASAKTGFNVENIFSSVSEMLPKDLKEKKKHHVRIIEKKKLFFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY60</accession>
    <name>L7JY60_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY60"/>
    <dbReference type="STRING" id="72359.L7JY60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0796"/>
    <dbReference type="HOGENOM" id="CLU_014923_3_2_1"/>
    <dbReference type="InParanoid" id="L7JY60"/>
    <dbReference type="OMA" id="WINKKPF"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="8">
        <location>
            <begin position="98"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="201"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="483" mass="55810" checksum="D6E5027C58F7BD6F" modified="2013-03-06" version="1">MIYHFRLCLKNPYDQKLRLIRFVFGWMIFCTLGFGMSFDELVINSLRKQNTQRNVETVVLLQYQPKNLFYLRKEEDYNFIKHRLLFMKSGYIELLELQDFSSINTVSVTDIIILGFIITIGEKVFVFNNTDESNDTLVELNLSEMDRYSLFPGQVVAIRGRNLNGNEIIVQEIYDSPVLPVNFFDEGDRGNNLKDNNFSVCFISGPFNNNVKPDEINSTDIYDRLFLSLDSIMTIDASYLVVLGPFIESRFLNSCLDLERVKDIFMAKMNTWINKKPFRKIITVPSTEDVHTLGMYPCASIDDGQNASFINLSNPTQFYIGDVLFSVCTYDILLHMSSTEIFFDINENVSLPESEISHRLDNIPKINPNSLDSCTPKVPKKSKRIERLSAHMIYQRSFLPCFPPRNIVSINRPECFDMNIAPDFFIISSKLKTFIQKDKGPFTVVNIGCQPNISNKQVLRITVNNRDSSSEERFNAVFEKYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYE5</accession>
    <name>L7JYE5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0706"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYE5"/>
    <dbReference type="OMA" id="ITHKENE"/>
    <dbReference type="OrthoDB" id="10482171at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="941" mass="109219" checksum="2619AF1E3D06F4B3" modified="2013-03-06" version="1">MLVNFYEYATNAVLYILVFKSVQRMNLNEYVALSDLSITNMSKFLTDLADNKTKCPYYSVHVYKYEQQAEDFSAMSTNVCSYSVKQALNVDRNDLRRYIEVLRTETRTRTFKIIEFEFSKTLFIKIMSLSMYTTTFFTQYEIHHIFKYIFLHMDDLALLAFSVCISLQNDPQIFYSLSDYTKKYKHLICSYQPCAFKCHHDYSNALMKFREVVNHKVELTLVEGDVARAKVYGHKQHSTILKSIVPLNEFKLGFLFECCDTKFTQVADLDILYDKFIYNGYNSRLTIIILENLTVENIFDIIVGTEDVMLKVPWFPSHKLWAQKHIERVTFRLHIYSSSDSSLISSHIKLLKHIRFASLMIDFVNSVPQPIYNVGICFLRYINAYVYNLPENVSTIICEHINFDYDFLFTKRFKSVSICDSVVEQGKTVTIEKGCETVTIINSRGQFDLSNAAGFNKIVLLNSGSKLSFQEKKDNHFNYITITFAEINESTIIDGSFNEMIFRNIKFNKIVTLLISDGAKHVSIYKTSGSLNFVGDFRGIVSFFSDSFLVITHKENEPRNISLFSCGVTDSLEFKNIYHSIVLSYMNLSDNFCFAMDETCKELSIDNCHGTYNLSKAGVLEKLKIEFARETSDKMKIIGPVAVNNLDVLEIPFNINELSHFFDQFSRIKSLKLGTAYMPIWRVSLEQHFMCQYAAFFQLRGPINNIRGESSNFLAYQNLYSHENWAMHGDEIMASIFYRKVVTEIEALEYENILMTDNNCRYLQRMNNLKSLTASMHNLTGESFTHLPRNIQSLNLYGSYIPNNDYKQCLNILKCLPYLSILTLSGDFFADTSNFQLLPETVKTLVISYEKQDVRNSSINDKKISLHKLYVRVLWQSIFHEYTKILNVELIEYLQAIFVFVERYDLECLIVSTAIECFEIDPTTYGVIHSYNEQTCHGINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYG4</accession>
    <name>L7JYG4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0501"/>
    <dbReference type="HOGENOM" id="CLU_428416_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYG4"/>
    <dbReference type="OMA" id="SWRTAKK"/>
    <dbReference type="OrthoDB" id="2193084at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="652" mass="76465" checksum="DA5B51D493C1CA3B" modified="2013-03-06" version="1">MNNSDKYVEPLLNVNLDDNKARNSLREYILRDSNSLTNREFHFLMEEIVAKFNDMKYLKFFLSFNFLLRGANKTFNVVFRHIFEGACSLEEYVFLQKEACGQIYQQLSFYRKKAQKYNSNDLLDEINNLVELSQKLYEGDALYECYTLLEIVADLIAIVNKFPFKRNTILYFTMLFNIFIHRGCLFSAANALYRLIRVEKKVNLKAEYVQTLVGLMHLKDNEEEHGRMFCGLPCIDARTFLQETKGVEYEQDMPFVLNEESLCNFIFYKQNIKKTFECDDKMLRFVSFLRLNNFNFSLDDGILIFDGTYCKKSNSAKVFEIVKGMKERRENVVVRNVEAIRIRENLKREKMIKETLIKEEKEDNQIKVEKKEKKARKDLFTKNFNLFRVYLMKSRQTDDPNDLKMRQYQLDMEYQRDYERKERLRQLYEQRKDSIAELLKNYEERKKKSIQPIAVTQEDVKVAKTSWRTAEPESFKTENIYKPKVESGKADSNIYQPPKITMRSSSFDPKEMSKPGVYDPSGAKRSFDSKEMSKPGVYDPSGAKRSFDPKEMSKPGVYDPSGAKRTFDPKEMSKPGVYDPSGAKKTTSKSVENVDNSKVYKFVRKNFMDTSTTDRPSHSKHADPHSTSNLGSSSEKPEKEIKKGESWRTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYJ4</accession>
    <name>L7JYJ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0912"/>
    <dbReference type="HOGENOM" id="CLU_1435380_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYJ4"/>
    <dbReference type="OrthoDB" id="2194086at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="189" mass="22543" checksum="5F7DCC998D39D77A" modified="2013-03-06" version="1">MRFPLMVFGIPCYISDSIRYIQISHKSLLIFEKAGILCDSIDLATIKSLHVKNEEKFFLRITYRNNLELVLKFDSYLNRDITKSLIIFVEKEIKERMRVDVGDRDLCNELTSKYHFDEKLYSSLTGEVYGQQIKNFGLYEIETKNDLLKCFIRLPYLLHVYVEMQVTLKQFFNLLKSSYFLMITMKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYP0</accession>
    <name>L7JYP0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monophenol monooxygenase</fullName>
            <ecNumber evidence="5">1.14.18.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.14.18.1" evidence="5"/>
    <dbReference type="EMBL" id="JH993912">
        <property type="protein sequence ID" value="ELQ75862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1176"/>
    <dbReference type="HOGENOM" id="CLU_594727_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYP0"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="460" mass="52821" checksum="A31FFBF6610C1F03" modified="2013-03-06" version="1">MVYSPCVIPWFIVCCHYANADSMEDRNNARTIDLNNYTINRNSYTINEDYTIKPAPYKEVTNSAIKGTIRKELRDLTVQELTEYKKAVNMLREHGIIDDLAILHTACETYAHNSTRFLPWHRAFLLYFERIIKTVTNKKISVPYWDWSIDAHAPTQSFALQHAWPINDTNHCFLVNFPSTHCVKRSPFIDAFYSTAQIKRMLKLPFSKFSTSFEIVPHAIVHLNVGGTDGDMAMLYSCNDPIFFQHHSYIDYLWSVQQIKGGNWYDGDFDEMMFPFDMRVRDVWKSMVVYKPYVIDYMDDSGKSRGGGLNGRSGRMNVNKDGIVKINSMNGNKEVMHREDKGDVLNRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIGEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYP1</accession>
    <name>L7JYP1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0581"/>
    <dbReference type="HOGENOM" id="CLU_2518847_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYP1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="9879" checksum="FFF4ED7D34466FB4" modified="2013-03-06" version="1" fragment="single">VPNSSALSYTILYSLVVPSRVYDRRMPFSLEEYFRMHGESVRVTCCCMFVGGDGIVKEMSVLRNIIDEYFTEYHGVKYFSIYRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYQ4</accession>
    <name>L7JYQ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0559"/>
    <dbReference type="HOGENOM" id="CLU_767681_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYQ4"/>
    <dbReference type="OMA" id="CFMIFEL"/>
    <dbReference type="OrthoDB" id="2192084at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="368" mass="44346" checksum="B72EBD5A92B59B0C" modified="2013-03-06" version="1">MKEDKAVEERGPPAYQTEKTCKNMGDSILDTKQASGYINDEYLRRINNFCQQISSNSESRTEIRKFFSQHPRAREILRRQVFRSDNYAILRMHLIINMKVDGKVLLHSLKGHNVSEKNCFMIFELYFFRLFDDIEAAKDKFAVLDDCYELFKRAESHAKLKIVEKDWERYEQRKYYEAFIKDRRLDVARMCRKMEKSPEILCRTKRSVDFLIVIDLDSFCHECEQLKRDNLEYLGPGSSQKRNLFDHSYIDSIIHKNNDELEIVLDFMKDNKYKYVLIHRKATDQYSYLHDFEAIRNENITWYTKFEHKPLLEKYGMKRCFILKNNTTYTRVDNDCYYISFDRLYNILVSFPLPDNQNVLKKDKKHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYR2</accession>
    <name>L7JYR2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein DRG2 (ODN superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYR2"/>
    <dbReference type="STRING" id="72359.L7JYR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0318"/>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYR2"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="355" mass="40333" checksum="8FA6D47D1BB606DB" modified="2013-03-06" version="1">MSIQDKITEIEEEIARTQKNKATERHIGHLKARISRLKLSMEEKKGKAVAAPRDTFDVIRSGDARVALIGFPSVGKSTLFSKITNTQSKIAEHEFTTVDVIAGQLRIEESVIQLLDLPGIITGAASNKGRGKQVISVARTCNLIVMVLTKEEEKELLVNELNEMGIRINRRKPRISINQTMAGGININSLEENNEEMIRFILKEFKINNCLVTIQDRITDEDMIDAITKRAVYMDCVFVYNKVDNLSLEEIKKIDGVAISSEKGWNFDTLKDVIWRTLSLKRIYTKKKGEFPDLDTPVIIRKDGKVSDLCKKIHKDFIKKFKSCLVWGRSVKHLPQRVGLNHLLSDEDVVQIYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYU3</accession>
    <name>L7JYU3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0352"/>
    <dbReference type="HOGENOM" id="CLU_057187_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYU3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="423" mass="48909" checksum="3559A1A323CCC426" modified="2013-03-06" version="1">MNCHLPHISNIMTKWILCFYSERENTPTDTILCDSLEDMNLMNVFTHLSEDIIKNKTLSVFKIEDYDTVNDPLKVLRPKIKEHSNSNTNIRDEDESMEGIDTTDMECSYDNSVVKNRNEDVSVKRDDPKDGEYKYRTIQIPVTKPLFMKVVNLKTDSNVKLSDDELYITICHLLTFLHNKTPLLQTLAQQLLDDSELSSRLSVIDKEQTEKNRETETKHSTNTPFRQELENAICEMLDCIDISTTDKFGNAAIAGRDSDSRSLAYADIYSLCYFFLPRYIRMDGYFLICNHELLCKYYENISSGFGLTLDIDFSDVFYRIEKNSTSEKDSTKKVAEQLNKVLKCEFLALDCLEVCIFRLTGVQNHLSFKDMSTKQLHIYYKECIFSERSQLPLNLKVLSISESKINCNLTLPDTLETIILEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYW5</accession>
    <name>L7JYW5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0827"/>
    <dbReference type="HOGENOM" id="CLU_810299_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYW5"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="343" mass="40356" checksum="F4C4D95247A61B77" modified="2013-03-06" version="1" fragment="single">VLSTMTILKNDYFRGFSLFESMYRIDGIFNMRYIRVLDHLIVGCAMPKANAIKKLLLKVLKEHQKKNAAIHWFCMREEPVIYVNNTPYVLRRYSVPYDNIEITGIDSNIVHKMEVQLKKDIYDEIKDNLLLVHDETLVKGTCVITHKWVEVEAVKTMREVYNIKSLIFHRVPISDERAPMPRLISYLYDTLCKVKGEMVLFFNCQMGRGRTTTFMILSYMTLIRNSLDTLPWETIEYRKPRFILIQQLLKFLPNARSSKKFADFAIDNFDHIENIRDIIEELAKSSVTKNIEKAQAFLLRYMYVICFAEFILGKETSFTDFLLNRPEIQELVASNLNTDLKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ05</accession>
    <name>L7JZ05_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993889">
        <property type="protein sequence ID" value="ELQ75997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1037"/>
    <dbReference type="HOGENOM" id="CLU_1714605_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ05"/>
    <dbReference type="OrthoDB" id="10515239at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="153" mass="18318" checksum="40D8BC369270DEC1" modified="2013-03-06" version="1">MSDGVLRIHAEELHIISDEIKERLVPIEAFLAALVDNRAFEKEIGNDLDLTEVRALRKYLQSTDITTKNVNMYKNELNYYKMFIMCFLFNKNILEEYKKMKIERELDENHNKTMKYVKTIFLFIIVMLIAFCVLTVIVVICKWFMRKKRPLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ82</accession>
    <name>L7JZ82_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993826">
        <property type="protein sequence ID" value="ELQ76724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0278"/>
    <dbReference type="HOGENOM" id="CLU_2998125_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ82"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6566" checksum="7EE98CACB655AEB7" modified="2013-03-06" version="1">MVLRSAFRNGRGAFDMVSWRDVDVWLFIFMCIFGSVIFLFFCGDGQGYVIKDVEGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ85</accession>
    <name>L7JZ85_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993883">
        <property type="protein sequence ID" value="ELQ76072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0960"/>
    <dbReference type="HOGENOM" id="CLU_3337993_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ85"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="38" mass="4255" checksum="8E174CA817DDBEB0" modified="2013-03-06" version="1" fragment="single">VSDASYDLCVKVTDAVAAYPFVVVRVCARQRTNFPHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZD8</accession>
    <name>L7JZD8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZD8"/>
    <dbReference type="STRING" id="72359.L7JZD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0379"/>
    <dbReference type="HOGENOM" id="CLU_1197393_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZD8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="232" mass="26633" checksum="89479A5039D41911" modified="2013-03-06" version="1" fragment="single">VKFSEKDNNGDLKRNTSRRYQGRYIYLPNTFLNHILLSKGLHPRIPIDLVNKYMNNDEGYKFFTDYVAHIYNMDNSIMALDTRFTIDIYSIVALDRRGISKNDLGTKVYEKLRQDTHDQLSTMIKDAKSRNIEALVITLPGSGVFGNIGYGNGAKVDPKYRDAIEKGAMKAIKDHGNGLSEIVICGHRSTPQVFKLRWYNKYGRVILISIAIVVILILTVVSIFFFLRRYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZS9</accession>
    <name>L7JZS9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0803"/>
    <dbReference type="HOGENOM" id="CLU_2098534_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZS9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="116" mass="14133" checksum="636E422816166BBB" modified="2013-03-06" version="1">MLPMYNLLVEREELRHKIKQLRDVENNHLYNSATEQIDKEVKRGMDRLNELEKEKLKSLKYFAELKCKLDEYKTAKKEDLREKIREAVVKYLNEINSWQNVGIEHYKRIEHMKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZU5</accession>
    <name>L7JZU5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0184</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZU5"/>
    <dbReference type="STRING" id="72359.L7JZU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0184"/>
    <dbReference type="HOGENOM" id="CLU_662546_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZU5"/>
    <dbReference type="OMA" id="FFIMEYF"/>
    <dbReference type="OrthoDB" id="2186239at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="148"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="415" mass="47879" checksum="164B7803EF267D71" modified="2013-03-06" version="1">MIKNRNVRSKKTAFYLRRRTCLLARSLLRAVFYVFIVCGCSVLVQIKLSYYFNHYFSSPLSACSNCPCLRFSSQRLFKLSMSSVLPSALVQIVHVFNSPLSACSNCSCLQFSSQRLFDSPSRLYFPFRKNKNLKICTVMELVYHVGQYKTVRVLGEGRYATVYEGINCATNQRVAIKITCKMLMAGTNPHFISNERRTYEILKNNARYSPNIVQFVDFKEDRENAFFIMEYFDGFTLQRVVYESLNNKEREKLTDSERKGFLMQIGDALQFLHALDIFHGDLKPENIIVRRQLIKLCDFGCSIVSSDRMCAAKRLVYNGTPGYAPPEVLDMGGMVNLEDLDTWAYACVIYYLYSGVQPFAKDNLCRTFQNLKMLEVGYDGLPGYVRAVCERVFRKQVSERIRMDGVMEMVKMFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZX1</accession>
    <name>L7JZX1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Ribonuclease H-like, LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0147"/>
    <dbReference type="HOGENOM" id="CLU_2160175_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZX1"/>
    <dbReference type="OrthoDB" id="2195487at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="111" mass="12722" checksum="CB5EB2DE515588BF" modified="2013-03-06" version="1">MVIETKKWMTEAGIIHEKTSVESHKSNGHVERVIRTIREAIEKIKVNEIGKAVKKIDDKCNKTYHAGMKCTPEKAWKDITGIAAVEKVRKEDTINSLRRENGKNLLKINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7K011</accession>
    <name>L7K011_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K011"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0360"/>
    <dbReference type="HOGENOM" id="CLU_1125243_0_0_1"/>
    <dbReference type="InParanoid" id="L7K011"/>
    <dbReference type="OMA" id="FFEGMER"/>
    <dbReference type="OrthoDB" id="10356095at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="247" mass="28632" checksum="273C81CEF06EFD1B" modified="2013-03-06" version="1">MLDVNDKTCWKCSTGMDENYVVSNLIDNTPLSSLSCVGCTANEFLIKERLNTGNNKGIEIRCDIRSINDLNNFVFLNSDSVVKITKNRFTYHYSKSETVYTTTGNLLKKIIRDLQYYLDIEIKNNDLDVKEKLWNHLYDDKKVYDDALLAYEDSSYENGDIYFCNDEMSNVNSTYSSSFFEGMERNEVAKFNHHNLDLVIKDKSCDLLIVDLEGVSRVFDNVGFSNGESYDDIDILNHKRVHHKWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K035</accession>
    <name>L7K035_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K035"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0380"/>
    <dbReference type="HOGENOM" id="CLU_2591471_0_0_1"/>
    <dbReference type="InParanoid" id="L7K035"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="80" mass="9044" checksum="927B36AE34470B85" modified="2013-03-06" version="1">MYSNATTISIVGEIVRKIRLSLFFCKHPIICAMGALIHTYLCPFFSVLSLFAQSRFHKSIGAKNDILLIARIIFKNIITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7K080</accession>
    <name>L7K080_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0530"/>
    <dbReference type="HOGENOM" id="CLU_2484914_0_0_1"/>
    <dbReference type="InParanoid" id="L7K080"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979176" description="Transposable element encoded protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9484" checksum="E3320C3012A6EFC6" modified="2013-03-06" version="1">MLSLTVISRVILLAINVHSISAYTNMVEPIITAMYEFVVTDFLLAKGIACIDDCAIAEQDAYEDIAINTMVPSAVIKYLCSLRSIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0A0</accession>
    <name>L7K0A0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0A0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0180"/>
    <dbReference type="HOGENOM" id="CLU_1595716_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0A0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="19005" checksum="F1BEDC2DC47F57F4" modified="2013-03-06" version="1">MTYSDNSPLEGYAMWFIIGIISLFTCLYLILLIIYTPAIRHQNNLRDELFAARTLIGNSGLNNRNLLHPDSLDMSLNRNFDLWRSSDEDVDVLSSSSARTASTFSSDYTSSEDSVLSNSDELWDYTPPHTPVDNFTSSSFHDDSSSLEDWPRACTRYQAYKCTFTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0A3</accession>
    <name>L7K0A3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_0463</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="JH993838">
        <property type="protein sequence ID" value="ELQ76552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7K0A3">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0A3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0463"/>
    <dbReference type="HOGENOM" id="CLU_000487_0_1_1"/>
    <dbReference type="InParanoid" id="L7K0A3"/>
    <dbReference type="OMA" id="KPCMGIV"/>
    <dbReference type="OrthoDB" id="2191821at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180034">
        <property type="term" value="P:co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="212"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1027"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1424"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1631"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1671"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1027"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1634"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1671"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1694"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ76552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1748" mass="193452" checksum="D3CE55DA566DA9B2" modified="2013-03-06" version="1" fragment="single">VFQNNNLKKIIFLPLKMQLQKKRIKSIQFGLFSPQELRASSVVRIDHPETLSNQAPKEGGLIDLRLGTTERQYLCATCGQSNLTCVGHFGHIELTRPVFHVGYMNKIKKLLETVCFYCSRIKAYDVHKEGVHRQGLSYFWGLCKGKTQCMHCQSKQPLIKRDGLSLIAFIRGEDNTEGKVILNGERVHTVFKRISTEECEALGFDEQYARPEWMIISVLNVPPPAVRPSVVLEGMLRGEDDLTHKLADIVKANANLAKYEREGAPGHIIRDYESLLQYHVATLMDNNIPGLPQSLQKSGRPLKSLSARLKGKEGRVRGNLMGKRVDFSARSVISPDSNISLCEVGVPEQIARIHTFPEHVTAFNKARLEALVRNGPNKWPGANFVTREDGQRIDLRFNRNSILLTEGCVVERHMTAGDVVLFNRQPSLHKMSMMAHRARVMKGKTFRLNLSVTSPYNADFDGDEMNLHMPQSHNTRAELENICGVDRNVLSCQGNKPVMGIVQDSLVGVRKMTDDGVFIEWYEGQHLLYKVVGSDDRGYGNDDRVYGNGNDGWGRVDGYSGDDRGYGYGYSGEDNINKGKDSNGILINYDTTHSTNTYTINSNIINTNPITNTNTNTNTINTINTNPITNANPPPTNTVRPAVLRPRRLFTGKQMFSCTLPCINYERGDVLIKHGILIKGCIDKKVVGTSQGSLVHVLALENKHIVRFFDSLQRVVNGYLLQAGFTMGVGDTIADECTLRDVMEGIRASKQEVRALIADARSGTLRRMPGMNLRETFESRISQALNRARDVSGSSANAGLGTANNVRMMVMAGSKGSLINISQMTACVGQQNVEGHRIAFSNQRTLPHFHKDDDRPASRGFVENSYLAGLRAHEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMENCQIAFDGSVRSERDVVSFLYGDDGFDGGRVERVEICGRDYYLPFNFERVYNEFTGGVVDKGEGKVSNIDREDRVSNIDGEDRVSNIDGEDRVSNIDGEDRVSSIDRVSSIDGEDRINIRTTLSPNNPSLTTNHNPSLTTITNTTIPNTTIPNTTIPNTTINKNTVLKDLLTFSPNRVLSFYLKLKADKLRLLDLKTLIRMSNVIREKYYRALVCPGEMVGTLASQSIGEPATQMTLNTFHYAGIASTITMGVPRLKELINVAKSIKTPSMLLTLKKEYADLKNANMVKNTIEYKELKHVIESIAVVYDPNVTDTVIPEDREFVRAHYLFPDEERADMLSPWVLRVKLSRNRMVRYGVTLGMVKAMVKQRIDVEVVMTDENAAEYVVRMRMVGECDDGRVRKVMDWVVGVRIGGVKGISRVYLLEDEGNDGLVDGAGGVDSKGSDGLVGGSDVDGRGIDGLVGGNDGLVGGNGAGGSDGSIDKAVDKAIYKDKDNNLNHTIDNTTDNTIDNTIDHTTNNTTNNTTNPTTTTNPTTTNRWMLQTSGTNLLEILHNEYITDCYSNDLTEVCAVLGIEAARNVLIKEIKKVIESDGSYVNQRHLMLLGDIMTSTGVLLGITRHGFNKKGSSCLMRCTFEETVEILLNAAAGSEHTNMRTISESVMSGQIASLGTGNVELLLDVHALGEKAFEFEHAPRQNVLWSPESGTCTDGVLSPAARYSPRYTPASPTYSRISSPSYSPTSPAYTPTSPKYVPMNAKYVLGSSRYSPTSPSYSPASPRYNPGRSAGSPQYYTRASPSYSPTSVRYYSPTSTRYVKGGVSPLYGQDDGEDKEEKDEKADKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0A6</accession>
    <name>L7K0A6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0A6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0164"/>
    <dbReference type="HOGENOM" id="CLU_1455440_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0A6"/>
    <dbReference type="OMA" id="TYINITI"/>
    <dbReference type="OrthoDB" id="10377186at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="196" mass="23319" checksum="3734FE4E947ABA8E" modified="2013-03-06" version="1">MIDACAKLFFLGNGISNFFNLIKIKPSTATYMRKSITDCKCNKSFVDAFTFDIETMKRDFIKDPTHENLHRIEQKYVLSMIRSFHKNSKKHVLYSIMYVIIIQRLTTNTECKSTLFLIFFLHFIYTNQFDDITYIEITIKDLEKINTIQNPFFAFYLDDLKRKGAFNVQFYPNYYFLHDLIAEIDDIEESVTKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0B4</accession>
    <name>L7K0B4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_0153</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0B4"/>
    <dbReference type="FunCoup" id="L7K0B4">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0B4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0153"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_3_1"/>
    <dbReference type="InParanoid" id="L7K0B4"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="202"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ76866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="424" mass="47689" checksum="597B31F1D343B04A" modified="2013-03-06" version="1">MGANNSRVPKLNPKQDTTSLNLRRKKQVRDSKFVPKLPTTRLPRCRLRLKMHQKILDYLQLEESLLSMQEDENENLLDQKSMVEQMRGSPLSVGTLEEFVDDNHAIVSTGVGPEFYVKILSFVDKDVLEPGSTVLLNYKDNSVVGVLEGETDPLVSVMKLEKAPTETYADIGGLDSQIQEIKESVELPLTNPELYQEMGINPPKGVILYGVPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPKLVRELFKLADQYSPSIIFIDEIDSIGEKRYDSSSGAQREIQRTMLELLNQLDGFDNKPDVKVIMATNRIDSLDPALIRPGRIDRKIEFPMPSAATKKIIFEIHTRRMTLDDSVNLDELVSSKEDLNGSDIKAICTEAGMNALRERRRHVCMEDFIKAKDKIFYLKQGVMPQNLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0G6</accession>
    <name>L7K0G6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0G6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0418"/>
    <dbReference type="HOGENOM" id="CLU_3353553_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0G6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="37" mass="4334" checksum="03824F20E78D7AE8" modified="2013-03-06" version="1" fragment="single">VFRATMAGHVDDTIHVRQRILFYIMDSKVLIKVLFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0H1</accession>
    <name>L7K0H1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cullin repeat-like-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993826">
        <property type="protein sequence ID" value="ELQ76722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0H1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0276"/>
    <dbReference type="HOGENOM" id="CLU_344234_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0H1"/>
    <dbReference type="OMA" id="CTQRTNT"/>
    <dbReference type="OrthoDB" id="2187379at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="822" mass="94834" checksum="9291F1355C360D59" modified="2013-03-06" version="1">MDHDQRATLRTTIQAALVRRLKSHEYIKSYNTVFKYCTQRTNTFEILGEKMYLILYAEIDTYTKDLTYTSMSEFINEAIRYERAVESICGVFKYLTRFYIRCNLDLRMSNVMPLKKMMYSLFYSNFACTIENVLVHSLDCTVIRFYYKLLLYSDALRKFEEVKTVYADNIVFDGDAGQKVQKLENCLNEVRSVFTGKNVEDVLERIRSRIGNVHDIVEYLCGRVCCRAYVNYEVIDALGIHGQLFERVIAGVLDEGMTVSEELRESEKLSGGVTMSEELRESVGLSERVTMSEELRESERLSEELRESERLREGVTMSEKLSEGVTMSEKLSEGVTMSERLRERITTTQGLIEDERITKTQGLVKNEGIEIKDEKQRMNVIDTGRTRARDTGESIKLCDTVNGHGGNTAQEVQNKGMINDRLRCEKLVLDEEGYQKEYVTLINGFIYCSELNDTYFKSEDYQKMLREAFLARIKDKRKVYDAIVQLMDRHVKHKVVQRTDEHEYGRAIKDRLAAKKWDVLIDLLEIFGDDLHKMVHLGVLRRVLLDENSLVHERILVARMEEKIKYFGKTRLALADFLSGIHRRGGIMNVTSAGIISDANVEMEQESDIELNSPNTLAVPGFSVRCFTKYFWPIRATCLNLNSRLEEMIGKISQSCKDRGYRIEFNYHYSKVELKINEHVVTCDAMLASLILDINDHKKINVAENKADIDRLVCAGVVIDQFGTHGDEQAENLEINDNLAQDVNLFSPEFKMPVSPERVEHCTAITGTEILKCKIARIMKRSKRMNVADLQALVNDNIDDALTWLLKYNYVKQVDDILEYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0L9</accession>
    <name>L7K0L9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993800">
        <property type="protein sequence ID" value="ELQ76962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0L9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0038"/>
    <dbReference type="HOGENOM" id="CLU_1066289_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0L9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="261" mass="30712" checksum="204A71D147442325" modified="2013-03-06" version="1">MLISSTVHNDLYQDITECEIALFLKAYIVNDYDFVDNGVLERQCMLLSNVIMNKVFYGSFDYSMKIRLTYLNLEDFELDERNVKMLKFFNLKTLILSGCSIKGDFFLYLPVYLKTLKLRSTPIIDDVWFRDDKSLCFTMKGFRSHQNLKSLVLNDRFLRVGSLFNNLPVHLELLEFVLCVKDVRLKLVRNFTKICLKSFTVKLIQDYDVKSPIEDSMKRDEIRISSFSQFAGFIEFEKLVELKFEVDGEVMVLDTESYEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRA8</accession>
    <name>L7JRA8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994088">
        <property type="protein sequence ID" value="ELQ74008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3073"/>
    <dbReference type="HOGENOM" id="CLU_360635_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRA8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="776" mass="88428" checksum="0AB7BBE0A99749E7" modified="2013-03-06" version="1">MMHDSKYDFGNGSINHFFHMINQLGSYLFIHSDDYGRSCAIKQKKRISFMYPSMTHATGVLIRFILLFKTEHGDYANDIMIANSLEDVQLASVSNDDLTKSKTLLSSLNFSIYDRLIDEMGIFKRDKRHEMIAISANGQKFVTSIETCSEDVCQYQYFKMKIPVKKSLFLKAICVSLHSDVQFSVNEIYEIIMGSFVLFMDNGQMIQRSVCQQLFGNENIYDQLNRIFVSKTRSSQSDQTAFICSFSTQYNDFIDNIKPTLYLHMIDSRGNILLASNIRKEESSLPAYTMSLNILFIYERCHITLSSSSILENHEQLYKIYKDPFSEKYLLVVDIHFDDILYDVQNRKNGAKISNDMIVDKIIGILKCNFLSLSCVQKLVLRFKSIDLAIDLNLRLSHDIDIYLNACKLVEGVVLPSNIKMLNMVYSHVLTDLELPCTLEEIIIKHSEIAEGKILEIDKSCKIINIEQVTGKVSIPHLEQNFWFKLSNSYSIVVKNNTSSLIEELEMHNASFLGNIIIIPPSIKTLTLSNVKLGSKAILKIFNDITSIKLHNFTGSVQLVDVNTGKDITIEIKSGSVELLKTNDSAKPNKFVLRSASLPENFIFNENITEIEMSDIKMQCGDFVEFSKNVQSVYLKNICGTVLFTCVGCLEKVVWLDCKRFNSNIFREFDTMILNVEDSLFDKNRMLLSSKYFCNNTIILKPAVKIFSFTNIMVPDQYILPIHGDFEKITLSGCIGKFTIPHIFKDGAATVQISGEKNILRIVKTSTGSYNIKLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRB5</accession>
    <name>L7JRB5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3119"/>
    <dbReference type="HOGENOM" id="CLU_1246169_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRB5"/>
    <dbReference type="OMA" id="CARVIFP"/>
    <dbReference type="OrthoDB" id="10428667at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="231" mass="27462" checksum="FD560B3A1BE98658" modified="2013-03-06" version="1">MIETTIYVSLIFVVFLIVVFIFILVSYVYIRHRNYSLLSKIETISDMCVFMADKSYLIIENYNNNLCDIFIITIYLKYDINDKQKSNDLDCYHTKHSCENVIQMTDNDSYLLIAAIDRKDTSIFMYNNVISKCAQFFFPNFLIFDVQKLMKFIFHSELNHHVVWLVEFKEQDTVVSVHSHDGQAVIHHDKMLKLKNFGNLVGKFFVFFINGFNLKYRQNKKKRHESIVNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRE7</accession>
    <name>L7JRE7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA+-type ATPase</fullName>
            <ecNumber evidence="5">3.6.1.3</ecNumber>
            <ecNumber evidence="5">3.6.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_3230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.3" evidence="5"/>
    <dbReference type="EC" id="3.6.4.3" evidence="5"/>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRE7"/>
    <dbReference type="STRING" id="72359.L7JRE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3230"/>
    <dbReference type="HOGENOM" id="CLU_327653_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRE7"/>
    <dbReference type="OMA" id="VYAYAEY"/>
    <dbReference type="OrthoDB" id="10412623at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="538"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="694"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ73855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="888" mass="101661" checksum="A344F00583898ECC" modified="2013-03-06" version="1">MNYSLWCSKGREKYTVYVATEELRGPVRINDVYAYAEYSPQLCSCNSILVGEFYATKVDCRKNVNVQKVDLPRAGIVYYKGKVEGLKAVRVLKTGTRIDKGEVLRMYERRECLCVPLPYYWEKEMEIGMDATVKRIFNNCYSVMNTNACITGEKERCSMQKENSNAQSNRCNDNEHIMHYGKSNGSASDSCNTDDHSCNEALNDEELSGGINDECLSDGKKNDNTNRIETEKNTNKNDEYFVVDEQTVFINVRNKCFTKRIYQDINPILKAYARAFNSNYFPKKLKNSKIDPIDTIVLSGEVGTGKRTFCMIVNDFLCANMKVEVYKRANLIRADEDEDNILDSYREFVEKTKEVFFFIVHTKRSFNFYQLGNVCDVKFSRPDRGAVQRILRDYGLDALNDAVGMNYYEIFNLIGEYRVYGNYGCVKKGYITLTDKRNNTCSVSSSSADNQYNHARVVSSGSEYYDSCIDDKAILTDKLQNLHLTENDASIIDDYLIRINRRTKRIQQHTFKNIAGYDDIKDLLGECLTRRYPKLIDYPTGILLYGPPGCSKTLFARSLSSTFNYNFVYFSASSIKSKWVGESERNLRDKFREAELMQPSLLFIDEIDAIATNRDTSHNHEVSLVNTLLSLMDGIDKRQTVVFGSTNRRNGIDKALLRPGRFDKHVYIGLPDEYDRKEIIRMYLYKEYDEDANNSNYSNASYNDKSAGSNDSNASYNDSNASSNYSNASSIGGNASYNDKSAGSNDSNVYNTNNIFAGKLCKENETNFKIKERNVKENKTVNLNINDIQTGDTISKEERRNKKKEVLGKNNVLRCKICLSPLVRRTFCYVKWSIIIKHTDGMSGAELKAAVNEGKMIFARRHRTNECIGMNWTSYILQGVQIIKEYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRF6</accession>
    <name>L7JRF6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994088">
        <property type="protein sequence ID" value="ELQ74014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3080"/>
    <dbReference type="HOGENOM" id="CLU_020887_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRF6"/>
    <dbReference type="OMA" id="MIEERIC"/>
    <dbReference type="OrthoDB" id="10428887at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="765" mass="89356" checksum="B741B0C6335BE33F" modified="2013-03-06" version="1">MVELKEIQVSSIDKDIPAHLSDKERCYFNLNMSAELLIQNLSNVIKRYKFMFTDDFVVNYGTNETKSNMFATDIDLCYHKNTEASSNFSHVHDSYYKLDCLGIDYCCYRGISLANILSYITPRSVRKYKAENERSFTGELIANDKSVSVVKKKSIRIGICDKSMDICGDSAVGSFVVRLDGLGRKGCFVLIRDSTGVRKKELCDIKEFIGAMDRSEPMSKKMKENQSRNTQPDNFPELLEELKNQNEEFDRKKMTRRDIIKQAEGSFSHLVDMLLTDSSLRQEINRDSEGYIICYVRSAQRVDKNIFIEYCIERRNLPVLPSEIEAFSILSCIPVQKLVLEYLNTQVKLFMVDGNVDMNAIIYNFRCAFYYNLMSGEEWIRREFHTMMVKLFEMIEERICERMVGYEKCSDALIHVIFMILVSSSKHSNEDVYPDIYACPQTVGSYAGIMENLRQNFTNNLFDLSTYYDLYKNCETTFRCGSMCLIEEKRFNELLNCLIIKNKKNFLKNYDYREEKCDDNSVGESSLIHDDVDSQGKDVSDSKSSGAKKNGFVPENNTHCDDIVMLNKISKLVPVQVVDSSNLFLRERLIRHFKLIFCVPWIKIKSFFYELKHSKIFNTRIYLGYEGYEDILDLNSILLDNENLRNPSEIFIFFKKLNLGDLQMIYTNKKEMHYLFGNSFELFYRLERLRIIKKFISKYKRTLSDAVIRKRYKGIAEIMEKSARFGVLGEDGIRTFKTVLYDECVEVVREMRMSIDMQMCKMIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRG0</accession>
    <name>L7JRG0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ubiquitin, Ubiquitin subgroup protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994086">
        <property type="protein sequence ID" value="ELQ74019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRG0"/>
    <dbReference type="STRING" id="72359.L7JRG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3070"/>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="InParanoid" id="L7JRG0"/>
    <dbReference type="OMA" id="ECKISDA"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="77" mass="8624" checksum="0D3996798023E3CA" modified="2013-03-06" version="1">MHIKIKSLIGVEKQIEIEEKATVLSLKQQIEMLETIPPEQQRLIYSGKILTDDGKILSDYNVNDGCVVQMVLALRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRG8</accession>
    <name>L7JRG8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3250"/>
    <dbReference type="HOGENOM" id="CLU_769842_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRG8"/>
    <dbReference type="OMA" id="CAQIRIA"/>
    <dbReference type="OrthoDB" id="10506791at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978746" evidence="1">
        <location>
            <begin position="17"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="360" mass="43073" checksum="9D67FCA0BE5451E7" modified="2013-03-06" version="1">MYIICMFILFINVLQCTNIVEQRISTLKTKLCKTVSNFHVDEEQMTYVKNCAQIRIARELLVGYQTECSVLKLNLWNIVNEWKNGVRLYVTEMASEIKSCVTKWKKECIDSVIRIVESSEQDKSIEDVKVTIKNEEIGDEKDVNYIIQEYDVENKETRRKQGDINENSTIQPDTSMYIHRNDKRYFKSWNTGIDRRSRDRDVINMMVAINRLFISDKDIDIAVNTYLERVYKNVYDPTVKLFNSSGLLHSRIINSVSEYIIKYFLTVNDKRTFIDKDITRLYDCINDKLKEYKQNYKKKMDITNVKVTNFIKLSLLELYKRYNIEINDYLERLNTLLEELFLRHKRQHIKKYEEVKLVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRH7</accession>
    <name>L7JRH7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRH7"/>
    <dbReference type="FunCoup" id="L7JRH7">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3062"/>
    <dbReference type="HOGENOM" id="CLU_122625_2_0_1"/>
    <dbReference type="InParanoid" id="L7JRH7"/>
    <dbReference type="OMA" id="ATWSRYK"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="3">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="14086" checksum="2D59F7EE0883C884" modified="2013-03-06" version="1">MEELDQKKLEIEEPQLLPEITIELLLLSTKKNILDIVCRDFYAYAMQHQENIPPVKHLKTIKGQVTTRKSPCGQGTATWSRYKLFVYGRKFEFRTTHDFLEKVATFLQNNDVEITLRVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRJ0</accession>
    <name>L7JRJ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Vesicle coat complex COPI, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_3038</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994081">
        <property type="protein sequence ID" value="ELQ74049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRJ0"/>
    <dbReference type="FunCoup" id="L7JRJ0">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3038"/>
    <dbReference type="HOGENOM" id="CLU_012709_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRJ0"/>
    <dbReference type="OMA" id="DREENSC"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="602"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="704"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ74049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="833" mass="94881" checksum="44F6F2ED6ABF3C25" modified="2013-03-06" version="1">MHPLIITAEPPIPKEKILSHLTSPKTSKKADALRAMITLLSQNADLSEYTTTAIREVCQCDDTQLKKIFYLFLEMIPKCDREGNMLAEILLIANQVRKDLEHPNEYVRGKVLHFVCTLMYGDVIELMFGPIVHNLEHLHYYVRRNALLCVTKIYEHFGANFPDIPDRIRRCMAKETNPYCLRQCYASLRVFERVTGTRLENGALVNEIVNMPFKNVPEELLGVVLCDAPSEELLWACVDSNKCKFQCALLLMQHRHSEDRAVRIILEMIRAEPSLKEIGLQCIKDVYYTRIQVNELLTLLDSNVMHIVFELVYRVAEIADYPIISEFVLSMIRQSHGDTPFLIFLIEQAIFISKNFNVHNAELNKTVQQFVLGEPEVAYVAINLLERDAHSHRYVLSVLHRIKYGRIFRRAVSVVASNNALAHDFLGKVDEMMAGNALSSTVYFGVACALALYKYYKERALSRKIVADKVLELIKRGRREECFDFSSHEIMASVLGDVLSDDEAVKENVDKNGKASGADSITAHSTGKDSVTGAITGKNDQANTGVNENAVHHVMTTERTQNVVKNTNRDVLDALSLKFLKSKRADDTDEQIRAFLCPTNADREENSCQMTGYSDHLYVEAAFRVSRLSVNIDLLVVNQTNKVIQNILFDFTTSCNIAHNFTCLPLSLGARSIIRMPFSFTIKEVFNGFITGCVSYTIKNVAHVLNMSTLSFRVNEFLQSRVLENEEFKTQWLGLEWENTYTSRFRCTRPVVHIFRAIAESVKAYVVDVKTDDNTFLVANLVCTTFLGEDVLINLKIRRDEMIHLDCRMRSTEEALVKSLSVVFSELLRRMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRK4</accession>
    <name>L7JRK4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2999"/>
    <dbReference type="HOGENOM" id="CLU_622851_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRK4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="504" mass="57674" checksum="A099762C01AF5DD4" modified="2013-03-06" version="1">MTSISMVNVVFPEPFVIDTNSNIEKLTINCYMGTIRLIGTNISGLLTNLYSLSADLEIIKLQDEMKYNVKIRNTLISEDLKIYCWLKTLELNTVRDKITSHISVMSKCESMKLRNHSGVLNMQPNLCFEMVFFSRAEFGYSMNTNTLVLNGELRLNTFFLPRWIEHLELNGLIMNNFEVFHLHNDLSDIEICNCIGTFNFADTFNIGELSIEHKNVIKVNNLKGLRANVHFKCLMLNRSLTISDNVAWIELNNVIMENDTVMNALSGCELITISWSLCAINWPIIKEEDVMICPKSGLWGLMRCPEDDLFEFDLYNATLTEQFVMSSSVVKACLLNVKVLRNISVVVNKSCKDLQLENCTGAVICHSLKLFDTFSVTCFDYSALFVHFTESSDVTLEISYEFNCRIVLRIALRSNNLSSIFLERYSLNNKVAEVTNHNTCSSFALVPIAPEQFAHNIEYAYETKTTNIDPMIIWKEHISINKAHRRLFGSQEITQINVRSFPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRP3</accession>
    <name>L7JRP3_TRAHO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3105"/>
    <dbReference type="HOGENOM" id="CLU_592100_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRP3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978753" evidence="2">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="462" mass="53896" checksum="E3A9ABD417AF986F" modified="2013-03-06" version="1">MKKFIVTLVIILCCKASIMHEEENDTRECCKFMTSGLDDDHESCNSTMHTEISSNEHDLAHDSERTHKKTDFSSKVTTNENETLPKSSFIAQNKSKDVEEHTTKRFSLCKACNFLNKSSKKAKIIRVFNIFRRKHKKQSASSANEDVIEKETSDDFKITTKPNPMKFESTGSQDNAMLESEVEVSSKATSDPNAGNSIGHTNKERSHLPQDINNANQSGLEKQHCEVFITRYYRTTLTTNVHSPTRYSFSQATNFDRYITMQDVEKNLFSKIGQIRSIEKQLRNNEVVQSSLFKIHSLMCRRCLFELGVTAVGLFLNQPLVYYERVYLSNSFQELIYWYHQSTYRLTRLYKSLYKAIKRLCYYKKKLLIFEGMLAKIRCHYQIVDIEFDLNTESGQKIDDFISYIRDTCEKVQDKRTIYASKGRFDKIQMLVNECTSILLYHQLFYVSNRPYIEILICNDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRV2</accession>
    <name>L7JRV2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3058"/>
    <dbReference type="HOGENOM" id="CLU_3034057_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRV2"/>
    <dbReference type="OrthoDB" id="10519227at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="6535" checksum="82D8809DCE6481FD" modified="2013-03-06" version="1">MREINKIELKASYDDFMKNLSELIDSNNPKADEYLDRIENAVFDILIELEENNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRX2</accession>
    <name>L7JRX2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monovalent Cation:Proton Antiporter-1 (CPA1) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRX2"/>
    <dbReference type="FunCoup" id="L7JRX2">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2933"/>
    <dbReference type="HOGENOM" id="CLU_008635_5_0_1"/>
    <dbReference type="InParanoid" id="L7JRX2"/>
    <dbReference type="OMA" id="FFGIRGI"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="6">
        <location>
            <begin position="47"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="454" mass="51647" checksum="552F3DC8A30AFD2E" modified="2013-03-06" version="1" fragment="single">VHKQHFLFPLSSIALLSFYIPPLIFNPMQHFFIILSLYGIFTLIFGLVSLLIKERLYISETVIATLFGIVIGPKGFNILEFEDYPTMLFYLSRMVISLQVVAVGTIVPKRYVVRQFQSLFILLVPLLLLTYAISTCLTFWMTDLGLWASMIVGACVTPTDPVLASSVLKGKFANRYIPTHLRHLLILESGLNDGLGFPLLTLPIFAMRLPFKKAFNKWLIHTWLYEIFLAVILGLAIGFVAKKLLVISHRKNFIDKENILAYLLALAFVVTGITGLLKSDDILASFFCGMIFAWDGEYQDEIKDSSLYEVLDLMINASFFILFGASFTSHIRYLPLALLIIFLRRLPLIIAGRPFIPQLFNMREAFFAGWYGPIGVGALFFITHANDCIKLDDELVKIVNMMVMCSVILHGTTAPIIHVSLRRRKRVDEEMYMTESEYTEVESDFKGESVMLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS49</accession>
    <name>L7JS49_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994051">
        <property type="protein sequence ID" value="ELQ74298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2782"/>
    <dbReference type="HOGENOM" id="CLU_1437763_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS49"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="189" mass="22225" checksum="422B55A8A7031EEB" modified="2013-03-06" version="1" fragment="single">MVKERIVSQIDSDYMYRCIYLHTDCDAAVHTIIDVLYMSVKYKLNITFDVFTFLNRTFLRLLHLGGRALVYNDYTSLPEAYFDGEMDIAEAVEETLTRLMELISDKTWQPVLMWNYAEHIETYRELLCVTKKRETAHRPARENVLHATEDHILLEHASLENRSTVEFFDVDAIFGAVYLDYASFLFKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSG1</accession>
    <name>L7JSG1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2657"/>
    <dbReference type="HOGENOM" id="CLU_1939595_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSG1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="130" mass="14390" checksum="AE7249392571BB13" modified="2013-03-06" version="1">MFSPFSPANYSNDGLKCDSERNQYREYTMLGSPLNQMDTVPSQKTTVSNSAKAAHSNVDAGTILSSANIYSSSYDNQYMTPIPSPSSLNYVSCQTPSDFDEPFSPFSSNYQPLSNAMSEDNDEFLCAWMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSK0</accession>
    <name>L7JSK0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_3054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSK0"/>
    <dbReference type="STRING" id="72359.L7JSK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3054"/>
    <dbReference type="HOGENOM" id="CLU_070980_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSK0"/>
    <dbReference type="OMA" id="ECNTRNT"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF18">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="338" mass="39470" checksum="655A77D48BEFED66" modified="2013-03-06" version="1" fragment="single">VEQVHIKEATLLRYHMFAHIITGARVTPIIQKCYPRYFQFLNILFYQHVLTNCSQHPIPNTNRFSINVSVRFNRFVHPQKVETRNFMFLIFNKKIRYPYMSFEDKVKELSLLGENVHCIECNTRNTQWASLSYGIFLCIECASVHRSFGVRVSVVRSVNMDKWNEEGYLRMKMGGNEKFKDFMRIQGIISLPTRERYRTEAVRDYMVCLKENVEKELPECVKTSSETTAYTTQRISAVPSASYTRLESVSSTDLRSSVSTALNKITDFVSENALYLKDKGIQVGCKLNESVLRPSTTYLKEKGKVFYSRFNGKDNKKTEFGQTRENMQVKYKDTSKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSL1</accession>
    <name>L7JSL1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2652"/>
    <dbReference type="HOGENOM" id="CLU_1284144_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSL1"/>
    <dbReference type="OMA" id="FFEHYDC"/>
    <dbReference type="OrthoDB" id="2191577at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="215" mass="25027" checksum="ED299E18E2E5D813" modified="2013-03-06" version="1">MECVISPPNALLLDKLFSVPVTVKLSVNMEIIYYTSEELRKMTLKGSFFEHYDCKCVRVFSIPKTNFFMSQMRFLRLVLNENVLILEFIFNNTKLIKYLDIIAANSIEIPSSSFYYDINIDFSLFTGTVDIFLRHDRVKVRERTNVWEKEAEAGLVNGCNLMVRIDSKTLKKINWYSKVMGKFSIGVGYEEPINLVFIGDGFIYSFFYAVFTQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSQ4</accession>
    <name>L7JSQ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSQ4"/>
    <dbReference type="STRING" id="72359.L7JSQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2638"/>
    <dbReference type="HOGENOM" id="CLU_605778_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSQ4"/>
    <dbReference type="OrthoDB" id="10515946at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="452" mass="52142" checksum="D5949F5D38D5920B" modified="2013-03-06" version="1">MKNILQQMMEESYNDRRRAKSRFIRSVVILLVALITPFLFSMMLMLFRILVFDSNTFKIEDVSYNAAQDPQNIHVTAGFANRSPLHVKVSDISIDFYVSTESRKYLLLFSVKKDETILQKGKQIAVKDHLLKIVDIRNENTLCLLRAKKIKIALRYKLSLRIFGVYLGRHMTSAYIIDLENNGSKVKKAVEIWRISAANDAIEVDLRFIGYVMSNFFRIYIPRLTLEVKCGDYLLDVIVDPMSVDNGVVQENLRVMLKFHPKHQLCINDIIKKVIKTRADNRDYLQLAICSLKNDCGIFNRFFDKLDVPILTLLSNSAGKSGGREDYQDDSPDINVNYDLKDNAIFLKKVGRGSTIFQYLFGVLYTLTLNCTIEKEMVAKIVIQQHIKDHMLKAKVELINLQRIIAAILNNDTIYMRVNLPNPTPQNVFRNFFISYAVKDGFVFSFSEITEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSQ6</accession>
    <name>L7JSQ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
            <ecNumber evidence="8">3.1.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="8"/>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSQ6"/>
    <dbReference type="STRING" id="72359.L7JSQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3034"/>
    <dbReference type="HOGENOM" id="CLU_271170_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSQ6"/>
    <dbReference type="OMA" id="IEDTWIQ"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="907"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="5">
        <location>
            <begin position="911"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="938"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="5">
        <location>
            <begin position="1058"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="715"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="940"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1197" mass="138516" checksum="3B720FB16F660917" modified="2013-03-06" version="1">MFYHFIFLSVLTILSYFLYFRKKYNTKTRALPQKKEHFRLSIANDNTLFALLCMNKDEPRIVEYKKGELVSVAGVILEGMACLRIDGRYYGMKSVGEFTVGVDEMVRMVVNDDGVSDRINDDGIRDARMGEESNIKDGIINDDDDDGRVNGGRQDEESNIKDDETKDEENNEESNVKDDETKDAENNEESNVKDDETKDAENNEESNEESNVKDDETKDEENNEVNPDEKNHRPCDKSGKDKRINSLKRRNVNTTGSDKKGIKKEKNKKENGSDGIYTIGNEKDVLLHFVHNEEEKRNDRSKYSNNDNSDKYNNNDKGKCNDNNDKYTNNDSDNYSNNDNDKKTNGVNRDRLNVTLIAETNLKVLVSCERFSSYAVFLYLKKIMHLCIKYFNLKRLIMRQDVIERSTITKEFTYEEYTVKDALIRDGVIWVVQGQVEVTAGSARIIIRNGVYGMINHVFKNMQCSLRAHGTVTYRRIDMQPFTYNDVLSYMRITRRMHKIYACIDWQVHSKDTKKFKDLVFLDCGRAYCNNAYYTKGCLNVRELMEYKTCDVRFVKRSYVLVMKRRMFRDLVRKCYGRGFVGRMSGENGRRKVVVVIGREREESLRFFGCLEREMMRMCGDGNDKDDEVVRDDKDDEILRAGGNNKDEDDEVMRDDKDEDDEVVKDNKDDELKRGKEENVRESDKSVEVKDNDNSKKVNSNGKQRKGKNRRGKNKNTNTNTNNNNNDNDTDPNISINNNNSINNGGERYTTSVNDLKPFRTKTTVNNKRTTKDASLQVRTQKKGGKKRPKKFLAIRHCNFIRMGELRFLELIKDVEIVLIYVENYFSRLMSFLVNYGDLILAVNLEHATFDFEVEDVVLYEERSNAGVSEGNGRKMHKIYGPCNKSTFCMKDYERLCRYIRGECVGLVLGGGGARGVAHVGIIEALLEYNVPIDMVGGTSMGAFVGGLYSISMDNFIVCSRVAYFCKRISSRWRLLMDLTIPLCSFFTGHSFNRVLYTIFKKRRIEDTWIQFFCITTNLCTYGEIKHVSGLMWRYIRASMSIATILPPLCDKDALLLDGGYTNNVPVDRMLEHCNRIIAVDVGSATHNAFTPYGDALSGAYILLNKMFTSNKYISYNEIQYRLAFLSSTYKQNKIVQDCNIVLITPDLSYRTDDFDKYREIMSAGYECGKRVMKRMRDKREYRQFFGKMRGRRRMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSV3</accession>
    <name>L7JSV3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate Permease (SulP) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994073">
        <property type="protein sequence ID" value="ELQ74121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSV3"/>
    <dbReference type="STRING" id="72359.L7JSV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2965"/>
    <dbReference type="HOGENOM" id="CLU_036921_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSV3"/>
    <dbReference type="OMA" id="AGCEWEW"/>
    <dbReference type="OrthoDB" id="2190497at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="68"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="543" mass="62544" checksum="BCD09CA4A2AFB90A" modified="2013-03-06" version="1" fragment="single">VIKELSITNTPIQMKKVETANSDKFKIRNMLSCVIMVCIFELMDMLSYSGAIMENYNSSKDIDAVCMILYIYPTISSMIFYNIFTTIPAGIVSSAIVENFRFFHKMSKNVRKNVDSEEALVTNSIFLFFVTGLLFAFSSIIMMKLRLGRLILQIPKAVVYGIFATIGIIQIPVGLQELMPNGYNHEHLSMYIIAFAVVLIVFVLQKRYPNIMYIMPLSMVVCMCLFYSFFIFQFKNDLIYELILHGWLHERDNRVINPSMLFNMIELETLQFGFLLKNLRTVLVCVFFSLLHVTYNLPSYKMDLNIEFDYSAELGTQGYTNLFTFIPCYFISCYSGPFYRSGGTKRIYGIISGLFLVFVALFGCSIRGYVPKFLLCMPPLLIGSTMIYDTLLTVISETKVFEQLVVFVISLISYLTEDYFLGVVTGILIHLAFYFMLKRRAISNEQRVSTYSEFLAGYTCIKIDFILCFMTMNKFKKYDFTDEKIVIDLLECPAVDWIGSDLLYDAINKPDKKVVIVGVPFNFNEKRFNKICKVLNNAEQLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSZ3</accession>
    <name>L7JSZ3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2664</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSZ3"/>
    <dbReference type="STRING" id="72359.L7JSZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2664"/>
    <dbReference type="HOGENOM" id="CLU_048466_2_0_1"/>
    <dbReference type="InParanoid" id="L7JSZ3"/>
    <dbReference type="OMA" id="ECRIRKM"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="214" mass="25097" checksum="C33E39D91C83AD67" modified="2013-03-06" version="1">MYPSMDQFCPQCKSDSYLNPNIKIYVSPCYHKMCENCVSRIFSQGESACPECGTLLRRINFISQTFEDIDVERECRIRKMLNRVFNKEEIDFDNEEEYDDYLEKYEDLILELMQLKNDMQISKRIESLKDDTGVHKNEIVAKRRRIQEGMDKSVGVVDNLRAPYDPLEDVEKPTVILKKAIELPEGYTYECTPAGYSKRITGYRAVYSLFDDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT30</accession>
    <name>L7JT30_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3190"/>
    <dbReference type="HOGENOM" id="CLU_2801168_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT30"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="68" mass="7396" checksum="00C74CCC767B9E9D" modified="2013-03-06" version="1" fragment="single">VVEVVPGEVLVEVVPVVAGDAEVEVAGEVPMKVEVVPEISSGLVTEASWATTEMSQLKDYWKVWTQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTD3</accession>
    <name>L7JTD3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2504"/>
    <dbReference type="HOGENOM" id="CLU_1571728_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTD3"/>
    <dbReference type="OrthoDB" id="2186859at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031543">
        <property type="entry name" value="DUF5087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17006">
        <property type="entry name" value="DUF5087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="170" mass="19928" checksum="4752D2D871E512DC" modified="2013-03-06" version="1">MLLSYQVLIMKRTNDSTDIVSKIQDEMDLFEPFDVNGLCSTILADNEFSHFKTASLRIICSFMDWNWTYNIFTVQTLYPQFVESSRPILLFYMGVICTLGYKNFGMHESVQSIFDEIKTFLDKENHELSVIACSFVKNFDLDLAGQWCAKNREKYGNQPWFEQILSKNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTE3</accession>
    <name>L7JTE3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA repair protein RAD50, ABC-type ATPase/SMC superfamily</fullName>
            <ecNumber evidence="13">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_2331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="13"/>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTE3"/>
    <dbReference type="STRING" id="72359.L7JTE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2331"/>
    <dbReference type="HOGENOM" id="CLU_824353_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTE3"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="12">
        <location>
            <begin position="5"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ74728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="337" mass="38337" checksum="E193D58039847425" modified="2013-03-06" version="1">MILNKLMIKGIRSYSPSTSNVIQFFPMTLILGENGTGKTTIIEALRYAITGDLPPMSRGGAFVYDPTLSNSTDTNAQIKLKLCDRYVVSRSLSLTHRKSKIEQKNTENVFSVIVNDSVSESYGNNMENLCNNDEVGNVLGWKKEEETNDRTKNTETKRKMKSLSGKAADIDKQMLMVLNTNKPLLDHVIFCHQEESTWPLSEPANFKKRMDDIFCSTVYIKAVENLKNVRKDKNVQLKMKLQELNFALQAKKKHKELLARLERANEDFMNNSGVISNLQSKLQVLNEKLCARHAIKKEINVESEKLLVLDVKLRNLKSKSMEIVDDEVVNKYRICAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTE6</accession>
    <name>L7JTE6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L14/L17/L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTE6"/>
    <dbReference type="FunCoup" id="L7JTE6">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2336"/>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_1"/>
    <dbReference type="InParanoid" id="L7JTE6"/>
    <dbReference type="OMA" id="IRQSKPW"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="15513" checksum="31B0FB79495059BE" modified="2013-03-06" version="1">MAQRGKQPLDTGRNRIRLTRGIQVGTILACADNSGAKMLKVIGVKGIRGRLNRLPAATLGDVIVCSVVKGKPDLRKKIVLAVPIRQKQIIRRPDAVHMYFEDNAAVLITNKCELRGTQINGPVAREACELWPKISSQASSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTE9</accession>
    <name>L7JTE9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2764"/>
    <dbReference type="HOGENOM" id="CLU_3056297_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTE9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6477" checksum="EC70291935442206" modified="2013-03-06" version="1" fragment="single">VFMDNMVVSFCFVLRERFDLSLLFTIPTSHVTELTMSRLSIHRQKYNSVYFISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTF1</accession>
    <name>L7JTF1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2341</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTF1"/>
    <dbReference type="FunCoup" id="L7JTF1">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2341"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="InParanoid" id="L7JTF1"/>
    <dbReference type="OMA" id="HRIGMLT"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="106"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="306"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="482" mass="54510" checksum="DABCD7C701232A5B" modified="2013-03-06" version="1">MSNYQRSNWRTSSRSSSYSQSPSSCSVRDNGPVDFEKNFYRESARVSEMSEKEVSEFRAKNQMKIIGEGVPKPIIDFEDINFGEGVLNYFRKKDFKSPMAIQAQGWPMALSGRDMVGIAQTGSGKTISFALPALVHAAAQVPLRPNDGPIALILAPTRELCMQIQEVVEEYDRFFNMRSLAVYGGVSAFPQRQAIRRGVEVLVATPGRLIDLMEQGCIHLSRVTYLVLDEADRMLDMGFEPQLRSIIPRTNPDRQTLMWSATWPQEVRDLAYSFMKNYIQVTIGEDELTSNRKIHQVIRVCDERDKVDNLVSFLNENDMKVIVFCNKKRTCDTLEYELGKHRYYASAIHGDKSQQSRDRVINDFKSGRKNILIATDVAARGLDVKDVQAVINFDFPPNCDSYIHRIGRTARGNQKEGLAIAFFTQEDRGNAAELVNILKNAGQSVPEDLAQIVPRGGAYRSSSGYRYSSSNRGRGSHGRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTN0</accession>
    <name>L7JTN0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2644"/>
    <dbReference type="HOGENOM" id="CLU_3227279_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTN0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5467" checksum="7E727D13CC85E8FA" modified="2013-03-06" version="1" fragment="single">VIDHALKDVLSCGSSYCRKTAYQELCIDCVAMWAAKLRTRTFLKWNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTZ1</accession>
    <name>L7JTZ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2299"/>
    <dbReference type="HOGENOM" id="CLU_3056296_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTZ1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6461" checksum="B40A96A7F9D64A76" modified="2013-03-06" version="1" fragment="single">VAIDSWFMKEINMPAYRTFPEKKGLLQRLDMQIIAYVVPLAQKYSEVFFFSDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTZ4</accession>
    <name>L7JTZ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994004">
        <property type="protein sequence ID" value="ELQ74958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2107"/>
    <dbReference type="HOGENOM" id="CLU_1442017_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTZ4"/>
    <dbReference type="OrthoDB" id="10588249at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="188" mass="21772" checksum="59DBD02172D20265" modified="2013-03-06" version="1" fragment="single">MFPCLNEIIIRSNDSEILKNLSCVSSTQVFTIRFESINLDTFTFLQVTGHKTITTVILEKVRFSFIDENTSFLIQSDDIVLANLTMIECELNDPRLINIFGRIKVKKALEVKKCDIDMEILAVMMGKDRLGELKKLELKENKMKNYQRLNMKKLEALTKIKIVNNKIYSEENISMHQICAFPTKTDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTZ5</accession>
    <name>L7JTZ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2140"/>
    <dbReference type="HOGENOM" id="CLU_2401230_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTZ5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="93" mass="9705" checksum="E7C182EFE700D01F" modified="2013-03-06" version="1">MVDNKISKKKEQVSSESDNEEEMRDESMSSSSLGSGSDTSSSGSESTSSESSKGSSDGLSSSEGTVMTDSTTDIDDVEESNDSAKEVDEGEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTZ8</accession>
    <name>L7JTZ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2551"/>
    <dbReference type="HOGENOM" id="CLU_2980756_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTZ8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="6698" checksum="8A175B57A585F26B" modified="2013-03-06" version="1">MISFSFLKLTILMDNINIHLEILIFKIYRHAALNPGTIELRRSVSGFLYNNISECLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU16</accession>
    <name>L7JU16_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU16"/>
    <dbReference type="FunCoup" id="L7JU16">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2272"/>
    <dbReference type="HOGENOM" id="CLU_001485_2_1_1"/>
    <dbReference type="InParanoid" id="L7JU16"/>
    <dbReference type="OMA" id="CIEPNIQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="4"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="432" mass="49682" checksum="B10209ADBBA10DDA" modified="2013-03-06" version="1">MSEKVNVYVRVRNKLTNELDGDQDELWFLKDNLLHQKIEDDKFISYFCYKKVFYMVDNCGLYKECIEPNIQPFVSGKSLTVFAYGQTGSGKTHTMTGKPSDMGIIGRTLEDIYNSMDEAAECYISYFEIYNENIIDLINTNNKPRVFTYNNELIVKGIERTLVSSLDKSLRLIKGCEERRKTGQTQFNLRSSRSHTIFKLELQNTNSTSTMTLIDLAGSEKASGTSLRIREGVYINKSLLALGKVINSLNKNEFTSYRESKLTRVLQSSMTGNVTLIALCMISPDRKCLDESISTLNFASRLCQIEMRNRTYSSKQLQTEPVICDNCRRELNRKDRKISVDEITDSSSAEDFTLMNPEKVKNKNSAEQIIQLQNKRIHSLESMIITLLGQNPSQRENEIFTLEKNMFNLQLEMLKRPDKINDEDLSFDQKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU74</accession>
    <name>L7JU74_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2510"/>
    <dbReference type="HOGENOM" id="CLU_1972019_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU74"/>
    <dbReference type="OMA" id="YLIEDSR"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="2">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="127" mass="15384" checksum="B1A606CFAA60508E" modified="2013-03-06" version="1">MHSCQFNLLLIVILSFTVIKTFLVLKNDIRIRIDDEFANLQYLIEDSRYKYEINRCGCTDIPAMRRDCMIWKSNMSKSRRDIEVMKIVMDCFGDIVDRFLERISWKFFIFSACLTVIYLIIYRNNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUB6</accession>
    <name>L7JUB6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIID, subunit TAF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUB6"/>
    <dbReference type="FunCoup" id="L7JUB6">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2146"/>
    <dbReference type="HOGENOM" id="CLU_327073_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUB6"/>
    <dbReference type="OMA" id="FCKNRLK"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="792"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="898" mass="102541" checksum="5D2240AD4C22DF5A" modified="2013-03-06" version="1">MHDDNYRPLDILTTPRPLTYRLHKYKVRRSAQQKLQFESDYTKKPTDTPSVNSVSNRAHNLIVRRHLRKKRFDREVLARWRAERAAGDYIVDDGCDQPINFVDWESRVIYDDRKVPASEHGDESEAESIGAFEEDERAPPPIKTPDIKTIELIRSIFNNEYWESQIIYDESNLNNFKTYVTINVNDPNLILERIDKRKVKKTKTDARRSNYNISNDRYYETLSVKSNLGNLGMQHSLPALRLDMGLFKTFLTKEELRNFHRPALSLLERAEKAIFSRTLPKSSQQSIKSPSQLTLTDSASFALFEYSEEIPLLVQNRGMVSLLTTYYKNNGNTPKKYLGKLTVLESEEPSPFIVDIKPGTCLTALTNNLFKACVFKHAVTDYLMIVTDSPVGEGTDDWKDESEEEIDAEEVARRNVVGHSGKMRHADDDRGRDHARKSAGTKNASREGNKQGVGKTVKPLKYFLRKINAAFTVGQTFPVEEVYSPHSRKLNIFCKNRLKVAAFREYQNNGLLSASYIEDLFPQFSEGSKRKWLKEYSDSFKRGKETFYQLKKSATVLNEEDLRGLVTPENVCQYEAMLCAEQRLRDCGLEYKENVMEEGELLLMPWNLSRNFINYVGGRGILEMKGPGDPTGIGEGFSFVKGNVKAADPEVIWEREQRSLSSARDILYDEVKGLIEERENRKSVEPVKPVVANTSSYVLITRVIDDEEHIEKITDPLVIKAYLKQRKKVRSEERKGTPKNVLRCGACGLVGHMKTNKSCPNFCARTLKGTSTPKKAKNLLTDLINKTIQRCAAMNYASAFLRPVSAKKFPDYLKVVTDPIDLGTMKSKSKNHKYANFGEFVSDLRKMWQNCVAYNGVDHGLSKLAKNMLELGEETMKSKKDEIIEIQNVMTKGEDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUI0</accession>
    <name>L7JUI0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LRR containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2389"/>
    <dbReference type="HOGENOM" id="CLU_408911_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUI0"/>
    <dbReference type="OMA" id="NINTIAC"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979042" description="LRR containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="77280" checksum="DB58A385803BE936" modified="2013-03-06" version="1">MFFLLLLLSHQSSLEIESSSTTSEELSDLSTKKQFKGSLKIHYEHNLEISSVVEIVKNLLTSGDNTGIEREFANINELSSLFSCSYSHLIQITCKIQNFVLHLYNQKETRNESEMRTPIYISDTCLTLYKEFFRKIGLKCLRIAIFDCISSYNWKLLFEFIDSHGSITSLYIKNYIEDSHTPQVQVPYELIDIKSSVGLCNIEMINLVIPMQVLAGLNNLELKCLRLVKCEIQLPPSKISSDIVIGILSDSFRTVHFVDCCITKNSSKKIISSKISTFDFNCLSKCINLVDLCILYIDCSLINLRYDHLKHLKKLTICVKNIGCRNLDMLAPCTRLKYLSIITSDMEATLGILRNINLQELQFFGLKTTETFMKTLASDIVLDFPTLEVFKFVAPSHKLTSRYRPLFNVKSMSNLKKLSITCESIDISVVQGICEFSELKSFNISLDARNNVLFEEISNNCCFKKSLCKLCLNAEITRITFTKVVASFVNLEELALSNDTIQYLCNHKTTVRGFINSFKSDLSQLFNTKIPEIPKLKRLICNDVLDLTTVKKFLLENKIIFAPYLLELNITMLIPGIFTANSATNSYAMSQSDQFGSSHHKSKNMVKLLKMLFKRYKRMKKITVELDNYGKFTPEDIRKFEATYFDKVRGVRKIQYRSEDYENDRIIWEFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUS3</accession>
    <name>L7JUS3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1999"/>
    <dbReference type="HOGENOM" id="CLU_799708_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUS3"/>
    <dbReference type="OMA" id="ICMEQRI"/>
    <dbReference type="OrthoDB" id="10335478at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="347" mass="41676" checksum="696A57AC68342CE4" modified="2013-03-06" version="1">MNLTKINKYLSENAEARSFIISLYDKSANTIPLFDYSPTKVLKHVLKRLGIKKIIKRNTISVCHLKMYFLFMFFEKSMSGIANIDIQYFYDLAIRLDPNEQLQVLQNRQELTPLTLICMEQRIKNMSINELFAEDERQITQQHKYFMLLLKCIGLDYDTATKILNALDYDYLCKMIVHSKYKEVRAYIKKLDYYFPQFDSLLHLIQISPKKSFKDKSINFLNDPLKIPIKCEALPYFKASIEYLQNKTGYKLENDKRLVLVYFIEEYRQKWLDNTKHMGKLYNFIECIVKEDVMILKILILRGFFHEAYHHLLEKELQTIRGWYKKDEENIYLNRIVNDYFKEITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUX5</accession>
    <name>L7JUX5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Structural maintenance of chromosome protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUX5"/>
    <dbReference type="STRING" id="72359.L7JUX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1770"/>
    <dbReference type="HOGENOM" id="CLU_367291_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUX5"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="8">
        <location>
            <begin position="174"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="420"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="759" mass="88651" checksum="0606DB79659AC34F" modified="2013-03-06" version="1">MQKTNTNPCCILTMATWKKSKNRKKEKRPKLRLEIKKIEMEMDADKHAEIIERVNQIREDYNILLYEFNKENAELIKDERNIRNLVETVRSNTKEIERLEKKAERNKALMKGTKKRIDDLKQKVDENTSNDLVRLKNRETELNEILGQFLRYKSFIKMDEGKDQIIKTLKALFPGVRGKLKNLLTVNQSRYVLPIEVLLGYHSQVIVTNTKDEALRCINYLEVKRLCRLTFFPIDSMKRLNKRTEVINGFVRAMDCISYSPDLQNIFECVFNDCYVILDSGLGRDKHRKYVTLDGTLFHKNALITGGPISVTLDHSIITELNEISAKINAHAHLNVILERIEEIKEENKIMCIEQVALENTINELRAHNETINSKNPYLNARFAEFDRQLKRLKAVKFKSILNGFSSIEELESFVNYEKIRARENEKKNLLAEFSRVKRELEHEIEELSAKMNIRNKEKDIKSNFERINKELKDAKAVFEEQRSASDRIVNEINAVNKELLVIKNETEKLENEKEEILQLGILEEIMSPDDVDKHVVAEGNIKEKEEELNSLNMKIEEIYATCSSGTAENRNETKELKELQKQYEEKKKESIDLRAELRGVKKSRLELFNEGYGRISDILHKIFSFFNQSAQLTCTNMAEPYLGEIKYYVLKDEYKFYDDLSGGEKSIALLCFILAVNKYFNAPFYFFDEIDSALDRTHMASLSEYLSSRNEGEKDDLFDNDQFICISLKKEFFKNADSLIGVYRSDSCSKILGYRLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUX7</accession>
    <name>L7JUX7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUX7"/>
    <dbReference type="STRING" id="72359.L7JUX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1827"/>
    <dbReference type="HOGENOM" id="CLU_002173_5_2_1"/>
    <dbReference type="InParanoid" id="L7JUX7"/>
    <dbReference type="OMA" id="MTKGFYL"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="355"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="527" mass="61973" checksum="A333F2E30D9F336F" modified="2013-03-06" version="1">MSNAKLQDLYVRQLYIGCDNSDCKMYFCRNDMSKASLLKISDILANYGEYFLCSTDRSKEAAKVNFNGKSCPIIDFYIYVLNHTTNKKSILPDSLSRHNFCSFFKKNSFNDEEKILIEGVFSMLLNQYVNYNENILSHIIIRLLSEILLKIDLKDEIFENISEIFLNIDKLCKELELDSEKHAVFRGTNGDGHGSEEESCMNCLFNNIFMENDLLNLIQTISMFLNSNEFDTIRSSKKFEELLNIFNILFCINERVRIVSFREFYLEKFCESQNLKEEIRLHKANYKTIMKYPFILPLHLKADFVKSENSDMMKNKLQDAFFRALFIGKTSPYFFITVNRSTLYKEVFKIFSKTNFDDIRKEIKITFKGEEGVDSGGITKEFFQLVSEELIHDKFLFTIQNNLLWFTEGKKNSRYEVVGKLIGVALYNDVVLNLPFPTFLFKIFLNKKVELDDLMEIEPEICQSLKKILHMSDEELCALEQYFFITRNDKSVELIPKGKSIMLTEKNKELFVEKYVEYLTYLEMKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUY7</accession>
    <name>L7JUY7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUY7"/>
    <dbReference type="STRING" id="72359.L7JUY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2217"/>
    <dbReference type="HOGENOM" id="CLU_123486_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUY7"/>
    <dbReference type="OMA" id="EYLRVEM"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="184" mass="21218" checksum="4EA5FFBF7AC1B63F" modified="2013-03-06" version="1" fragment="single">VTHKMQIFYPSMDAIITRYNKAPIHCNIYSLVNLKVACNDLLIEYLTKEKGYRQKHTYTDMKIVVGLISVVCAALTCYMSMNYSFEDYRKALVVVLAVYFSFNFVLEISLRLFARNTVFEGYNKEGSIRIDGFNRAVDTDYKLIIYKNGKAIPGNFCKSVYELYDESGVLDHEAFLREVAQVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV11</accession>
    <name>L7JV11_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1875"/>
    <dbReference type="HOGENOM" id="CLU_943943_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV11"/>
    <dbReference type="OrthoDB" id="10370836at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="295" mass="34211" checksum="DEDD97799DEFF989" modified="2013-03-06" version="1">MILRAKSVRLCIITNILTVFVVVTFVRRLWVIQHLLYLSFCSYLFYLCVTLVQKIFEYNFTLVCIGEKRKELKDVSKEEDLSNYTRFFREIGVNEGYIDKTNDNLIDALNTERNVLNSGPLCNTPVKLTNEQINGARIAFLSLKSSETLLPAEKKIVRLAYETELVHLSNTIKQIRAEEKIYFERLWKKSAIIVKNKEVPSQLTNTESIHVNLVRSYNVFEVSMAWIRKKVMSVYFQRLCAESIYFVERYHAYCYSDIVGGLLFELQSAEIAFGADFCSSKLLKSVNTAKKAFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV12</accession>
    <name>L7JV12_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993972">
        <property type="protein sequence ID" value="ELQ75313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1740"/>
    <dbReference type="HOGENOM" id="CLU_2856133_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV12"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7622" checksum="1DC969AC9A0BB218" modified="2013-03-06" version="1" fragment="single">VAETLFAELCLRANEVTRIPAINDYALSFIVFEMILMTHKNIFVYRDIRNVSPMVKNHGYFQPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVE5</accession>
    <name>L7JVE5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1641"/>
    <dbReference type="HOGENOM" id="CLU_2392081_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVE5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="94" mass="10571" checksum="68F0D15831A75064" modified="2013-03-06" version="1" fragment="single">VNVSSNHVVIVNENSQSVAIIFSEIDFDLSKIKKLKNLNLIVKKKGLINIQFPDLSHVKTLEVSFGKNGKIFNLLLSKYTNAKKLILYNTVLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVK2</accession>
    <name>L7JVK2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1555"/>
    <dbReference type="HOGENOM" id="CLU_2777703_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVK2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="69" mass="7731" checksum="376ED235A1859789" modified="2013-03-06" version="1">MLVLTYFWAANAMHLASISRQSVLQESNEQSVSNAEEMDSESVELSSCSNKSLSIEGLVTRFEERSMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVL7</accession>
    <name>L7JVL7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1731"/>
    <dbReference type="HOGENOM" id="CLU_912722_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVL7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="305" mass="35604" checksum="4B2B99B224915CD1" modified="2013-03-06" version="1">MFIGSYLYAVVASLPYGQFCGNEETDCIIRIEKDEYDPGFEYCPYKTKLDFLLSCLLEQIANLYSEIISKEPKILEFLQFTALTEAKCNSKSVDKYMEDLLVNIKSKHTFSDHMRRAVKHFNRKNGNRPAIIDPNASFFYFSRDETIDTLKYVTTILGAVLRAMKRSKILDNEIFTMLVSSNNNWYKDCCSIYTMFPRCESVSIPANIFNNYITNHNKFAQAFDKFLEKVFPGDSLDKLICPSASKINIDETLIPESHLYNVSNATERHWDDLKWNDEKDFVERFKFILLLLPVLLFLILVYLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVP4</accession>
    <name>L7JVP4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1539"/>
    <dbReference type="HOGENOM" id="CLU_2706554_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVP4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="8368" checksum="E5CF574F5151BAB6" modified="2013-03-06" version="1">MKIAKHLLKLVKDVYLTVHIRSPHKYLSSFLHVEQLGSFITGLCAEYCINERNQASLARPKVINKREVINCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVR0</accession>
    <name>L7JVR0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1688"/>
    <dbReference type="HOGENOM" id="CLU_2607716_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVR0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9102" checksum="84F7051F291AC70D" modified="2013-03-06" version="1">MYVKMQMQNRSIVVALKSIDDRATIRLDTLCISKGCTIQKFNYKSFFKKLFIPGNDTIRTRNTVLKLELLFLIAGVSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVT9</accession>
    <name>L7JVT9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994014">
        <property type="protein sequence ID" value="ELQ74862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2201"/>
    <dbReference type="HOGENOM" id="CLU_678234_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVT9"/>
    <dbReference type="OMA" id="KMQFIAQ"/>
    <dbReference type="OrthoDB" id="10545048at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="406" mass="46448" checksum="543BA8ADAA5F0D80" modified="2013-03-06" version="1">MLHKFFMVRKQKLKGKRDVVLELLRNKIKERYTRNKGGVGYGLDGGNTGSETVIENEVMRRNAEHARNTSDSRDGGNVMNRLDGKASTTNKHVNTSNKEIPHHSTIHHTVAIHPSHLRKLSSSLRTIYRFNSLKNRKTLFNRSRHIIENITKRRVDWNDLRKIKWLDGRYTFAQEGDDLVVCGVGGVVDGLGGGMAALYDGDVVVDVNNGNAVDSMTGKNECKDRRDETHVITAVSDSRGVENTIEDSRGVENTIEDSRGVGNTIEDCKSTLDRIRGKTITTDKNQNKSKRENASLTTAHLRKSSMNISTNKESAHQKYQRILDRIKTRECVRKMQFIAQQDNEASYSFRTDLINTFNLESRTCYEYEELKSRMNYVCDIEEEIRKVEGFAVVNRNGRRYVMRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVV8</accession>
    <name>L7JVV8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1497"/>
    <dbReference type="HOGENOM" id="CLU_2967566_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVV8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6819" checksum="993F8C3C6B9FF92D" modified="2013-03-06" version="1" fragment="single">VLDEQDGNLLTKTDIDLRNYIHKLWLGNLSSDKPMAQNGMVNIDITSMFQTDLFENIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVZ5</accession>
    <name>L7JVZ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA helicase PIF1/RRM3</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="JH994007">
        <property type="protein sequence ID" value="ELQ74927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVZ5"/>
    <dbReference type="STRING" id="72359.L7JVZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2135"/>
    <dbReference type="HOGENOM" id="CLU_001324_11_0_1"/>
    <dbReference type="InParanoid" id="L7JVZ5"/>
    <dbReference type="OMA" id="EDANMRT"/>
    <dbReference type="OrthoDB" id="3353471at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8113" checksum="564BB409BCFB6F8E" modified="2013-03-06" version="1">MTIHKSQGQSFDEVGVYLYSSIFVHGQLYVALSRVRHADGLKVYIVDNDDQSKADNNMVYTKNVVYNELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW33</accession>
    <name>L7JW33_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW33"/>
    <dbReference type="STRING" id="72359.L7JW33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1330"/>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="InParanoid" id="L7JW33"/>
    <dbReference type="OMA" id="EECYRTN"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="403"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="582" mass="66740" checksum="8EDB2A9E8AD6520E" modified="2013-03-06" version="1">MNHKRMEGNVAFKSKDYKLALAWYEDSLKDVLELTKAVDWHANELEMMKVIAQSRTQCTSNRITDVKTNLIAKTAIPVGLRLKVCGTFSTFLKNEHFLVLLNISTVYYRQYDLQNAITYAQMAYKIREDDLSCSKMALYLLRNGDMSFQMYYDKINDKTPFVELRNAVDSMVDQSTVKYCKNVWGDDINRICYGSDTLQTYLENLMESDGGAQKPQNLDEHASNGNVAEEKEAHSTAVKGSEGFAEVSGVKDENDQEKGTSIEKENCGENTREDMPLKDVDTKNDNIRLGGLNGALLVEPFDLKILDIKFVLRVLLDGIKHYRNVFNVVKINVKEKYYVFGDTHGNLVSTYNEIRKITGNFSLSFRDHLIFNGDFVDRGKHGLELVIFFILLKLSYPKNVHMNRGNHEFAGTNRQFDLYDQIAKRYPFHGTFVYETINLFFQTLPLCTIVNDDVFVVHGGLPADRFTVQDVYKLNRFVSKIKNELLAGLMWSDPVEIAGHEPSRRGIGVHYGQDVTERFLSDNNLKLVVRSHEFFEECYRTNHNGKTVTVFSSVNYVNSANSAVYLVFDGDRYENYKVVRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWA7</accession>
    <name>L7JWA7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1276"/>
    <dbReference type="HOGENOM" id="CLU_785704_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWA7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="353" mass="40696" checksum="38324836FF60DA8E" modified="2013-03-06" version="1">MPYKRGYSPTPPQFLKIIIFCVFFSTCIVTSVLIWTSIKGSHVFSSTHPSDEETKFLCDSEVNGKMIDLGFEAPKNNYYGCTNDENTDEYYNTCLKAAKVPAMNEERKVQTILFGGRDLKVETKLEYNIPNPLDEVQYDVKDRKLNTFKESESNDVLCEGYDTSTSVSYIPKRYPEGNNWYNGVYSINIKPSNGLIREDYELNSDTTEKLTTTTKTDSQIDSQIVLPIEHSRNSFENTNETLPTEFYFTLTYTECGFLNNSECFSDIDLSDCFVEHDSNLPAEKSLTEFENANDTYKPVQYDSHNTGSPARKMDSTNLPPGKTRNKLSIWQRFKAFIYKFFSRIRLFTKFVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWU4</accession>
    <name>L7JWU4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993927">
        <property type="protein sequence ID" value="ELQ75770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1272"/>
    <dbReference type="HOGENOM" id="CLU_2661430_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWU4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8738" checksum="8760543841FFD55D" modified="2013-03-06" version="1" fragment="single">VIKRCRCWGLTKSRKKQIMVRLGCVDVRKCLLPSKQRWRIINIGVNDSVVIFFGFSADRMDIVKSIIRFVDKAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWU7</accession>
    <name>L7JWU7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell cycle-regulated histone H1-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993905">
        <property type="protein sequence ID" value="ELQ75904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWU7"/>
    <dbReference type="STRING" id="72359.L7JWU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1127"/>
    <dbReference type="HOGENOM" id="CLU_069888_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWU7"/>
    <dbReference type="OMA" id="AYIYIEY"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="220" mass="26089" checksum="EB1695DD90D1117B" modified="2013-03-06" version="1">MHKRIDENDQQAHTIGYRAYIYIEYAHCLIRNVNNYFQTLLLQLNAHQPSMLQKKEIYEEDLEIAWNVLEQARLFFKMKNDKHQLKKVYFLQGEIYLLNDQHADAVREFSECLLVEDEQFVCDGTVYKRIGDCYFFLGDRMMATTFYEKGVVYYNGVGNARKSREMELLLMSARDREEMGFREEEHKIGEDGHKIGEGENERVVVDVNHLIRKKSVEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWV2</accession>
    <name>L7JWV2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993944">
        <property type="protein sequence ID" value="ELQ75541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1499"/>
    <dbReference type="HOGENOM" id="CLU_1682194_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWV2"/>
    <dbReference type="OMA" id="RIIHHIS"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18414" checksum="56B052389DBB250B" modified="2013-03-06" version="1" fragment="single">VKNLLELFGNVYLTVYIQVMVGNLGKSLKETWDLQFITGLCVEYHNSDISSKQPSFSQIIFVSVLAKLDKLETVKLINILVDETVLEKLSMNRQMRNLNFQKCYFYSRKKILRDRDLDGVNFSESYESICFEMCGENMHQKNFRRIIHHISSVFVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWY1</accession>
    <name>L7JWY1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1106"/>
    <dbReference type="HOGENOM" id="CLU_621431_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWY1"/>
    <dbReference type="OMA" id="TVIFLME"/>
    <dbReference type="OrthoDB" id="2194817at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="456" mass="53051" checksum="15C91CE5D34E9892" modified="2013-03-06" version="1">MFHFKVIKWRERALPMHLIGYSFILGCIHASNVVNDLQRRLYYESMIDLDTVIFLMEVNQMNENECKELVQDVVLPMRYFLVNVFSGKAGGASLIGEKNKDRKFVNDEDDPEITKRKTELETKEIQNIKSNFEKNEKSRKDKRNRNGTNINETLMEILKATSNFSLKVKSKFSAIDKSLERRNRYFEFDQSQIAKYLFNAAHQKLMKDLETFLQDNSASSSNPKKSSVRELLSIKDANKKDLKYFQMIETIEKAVVETDNIVKIKQREENEFTLVFGQQMKQDEVKALKMSFNLGSTFLTPGLYLSISKALMISEKSVFVEKMTNIMLKPILTLTNTSSIGADTEKKENVLNFLKDVVSRAPSKYTDEIDGAFKARSTILDKFLRDDKDELKERKMMQIDTVLEKRNKELLSKIESMRAEHFKDFLVLNQEIVNVYIRFLNSNSTTDRSKLSAYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX28</accession>
    <name>L7JX28_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1026"/>
    <dbReference type="HOGENOM" id="CLU_2514227_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX28"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="9637" checksum="F1000DBEC4B3B81B" modified="2013-03-06" version="1">MTGKENKENEILIDTSLIMLKKIELDLKRMRQNANDGTDNAVDLYLSDSKKTKKGRFGGIKFIVLLTIILITVSVLYVCHKLGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX35</accession>
    <name>L7JX35_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1789"/>
    <dbReference type="HOGENOM" id="CLU_3109782_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX35"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="51" mass="5689" checksum="EC13E0690A54F7BE" modified="2013-03-06" version="1">MAKSKKNQKQTEDKPAKEETGTVKKQAEESTTSDKKEGKHGKKKNSEQGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX51</accession>
    <name>L7JX51_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1755"/>
    <dbReference type="HOGENOM" id="CLU_3263270_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX51"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4696" checksum="C636C91E455461EB" modified="2013-03-06" version="1" fragment="single">VKGEFLGRNRCFVIGGLFYMLAALGVSTFICIIPSLKRKVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX55</accession>
    <name>L7JX55_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major Facilitator Superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0963"/>
    <dbReference type="HOGENOM" id="CLU_584071_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX55"/>
    <dbReference type="OMA" id="QMIYTGT"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="14"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="481" mass="55169" checksum="E9E4EF467CBED9E1" modified="2013-03-06" version="1">MEPFLNMIRSYAIPLKLLYFFINVQYYAFYQFRGPFAVKMFDVSKEHYGWFLGIILAVCFFTNTFLATANDKFERPKLFICTLLVVSMVSFELFYFWPAVKKHEGIFWLVMFLYSFFNTAIPPLLDRFAIEYLNRTPNVGARTYGRQRLWGTIGYLLGNMAVESLCRTEPKKYDFDNLKYYVPLVTIPAVLFSALFIKSYDRAERSNADIESSWASFLKNRPYLFFIFIILLNGITRAGMTLYLSIYQTEILMLEGYTLSDRIPGFLRSIINVVNKNPISTTATCGVVFEIIILYYSQNIVGRCGLYWPLLFAQVAQFVRFAGYYILPYDNSNTYAFSCLLETMKGVNFGLTHSSGVHIANMMCPPHLKATSQMIYTGTFTGLGSFFGGQIFGLIFSKLSSKSATASEKAKIFSNFYIVNMLITSFGIALFVYKYGMRDRVLSMDSLLGKTQQKKVEDRKVVMDVDEDEGDNKPSNPKSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXA1</accession>
    <name>L7JXA1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0933"/>
    <dbReference type="HOGENOM" id="CLU_1595718_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXA1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="20184" checksum="C2C07D69169188AC" modified="2013-03-06" version="1">MREILMVPFLISFCCHPYVLCLYIWLFRLENHFLITNDYLYFNDTGAQDNSFSIVFFYFFSVTHFYQLPEQLLRLGRTYSTKTIDYPIFQLATFRIRYFELYNVLKEFGCLQFINPLLYDHVKNYFVDKSYIRLYKSLNNVINLLKCQSSDDIENFLQSMTFNTNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXD0</accession>
    <name>L7JXD0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase (Reverse transcriptase), Non LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993876">
        <property type="protein sequence ID" value="ELQ76089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0942"/>
    <dbReference type="HOGENOM" id="CLU_403668_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXD0"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="682" mass="78453" checksum="3A86800A4DEAF093" modified="2013-03-06" version="1" fragment="single">VQTINNRKQRGSIHPIFNKNTNTLACSTIEIRNVWKSHFQNLAKDKEGVSKNRGTWQNESPKDTFQLCNKPILWSEVTRALKNTRRGKALGIDGIPVDIYKIVQDDVEMKSPLSRMLYLILHNVFEEGTIPTDWHRAIVVPVPKKGDLNKPDNYRGISLLSTISKILTKIIADRISRICDDEKILIKEQAGFRKLEECVAQATSLYEIVKRRLLKKKETHAAFIDFSKAYDRVPHSALLTKLKQYGFGGKIMKYLTATYENVVAHVKVGDEISSEFRYDIGVRQGCPASPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKAIKDIIGTRINYCRKAAYKELKIESMEMRAARARTRALIKWRNSRTTIGTLYSYEFKHRKSTWITGTKRWIKKNLKTNRITEQGEGLELVRTKLRERYEKNDRSKCTIQRRKWNINKPLTIWKTITKKNKINNGWKQLIKIRLGVFMYGYRLAKCGIIDREFKEKCPCCGEMRKETLLHLFLECRRWNNERTRYLGWVETMGMPYNSINAGQENKVTGLLLGSNEHIHESIKTRTLVGVANFLDAITGTRCDIIESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXF8</accession>
    <name>L7JXF8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA+-type ATPase</fullName>
            <ecNumber evidence="4">3.6.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.3" evidence="4"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXF8"/>
    <dbReference type="STRING" id="72359.L7JXF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1388"/>
    <dbReference type="HOGENOM" id="CLU_778907_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXF8"/>
    <dbReference type="OMA" id="ICARNEP"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="104"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="328" mass="37523" checksum="D37439E3CCDFB7FA" modified="2013-03-06" version="1">MVQSLSKLVIETTKRANLKTRLFNTIVSLNTQYNGSTMICEGYTGSTRHLSGTFRVTKETKIKVYKGTARLFYELVIDIAVKYRILDHFFRTNRYRRIAKSMGISRTVLLHGPAGTGKSALCRAIAAKIAVRTKHTKTVEVHSAQYVSKFYGESAHKLNELFKSVDKHTVVIIDEVDSLIVSRDQICARNEPLDSMRIVNTFLVNLDVSGCFLMCTTNLLGVVDRAFVDRMDMVVRMYYPCEQHVHRMIVNALHVLMLKNVIRFEVLPDCYGPPSKRMLAVSRAIGTASARRIKKMLFCAMHRDVRTVDDILDRLERIIEEQRENEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXJ5</accession>
    <name>L7JXJ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993887">
        <property type="protein sequence ID" value="ELQ76045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0996"/>
    <dbReference type="HOGENOM" id="CLU_3387202_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXJ5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="33" mass="3641" checksum="30D55F9E97CD3B39" modified="2013-03-06" version="1" fragment="single">VNVTIKFVCSVDVRLVMDVVIQCLCTQASDVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXL6</accession>
    <name>L7JXL6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993867">
        <property type="protein sequence ID" value="ELQ76154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0870"/>
    <dbReference type="HOGENOM" id="CLU_2639854_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXL6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="77" mass="9730" checksum="93D77F0F84C1B231" modified="2013-03-06" version="1">MHILTKPWKTKSKKIQSCKFDIHQQRRLKAMKKKENEIFRSMVNEIIQKKRRYIEKMQEIERKKTEERILAFKRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXS4</accession>
    <name>L7JXS4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI-anchored wall transfer protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXS4"/>
    <dbReference type="FunCoup" id="L7JXS4">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0820"/>
    <dbReference type="HOGENOM" id="CLU_706360_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXS4"/>
    <dbReference type="OMA" id="LIEGYKC"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="391" mass="45301" checksum="7212320286E6110E" modified="2013-03-06" version="1">MFEKEIETSFIIAATIYPSILRKGIKIGNNLFIDFISLILPQYIILLDHKLAYVLVIAMLAPFVKRSNLHGRTRNWSKSCRVIRTLQATITVSCIVINILENAEMLSEKFQPTTFYGISVGDLFRSFIVLIEGYKCARKSKESIHRRFILSLMAGIVICFINLVLGIKQDITQYGSNLNFFLVLSSSYIFFMIFKSKHNFKLALSLIIVQEYYLRVGKLDEVIFSEKRTSWMMRNKEGLNAILPTFVMFLFSSYIGRKMTNKRATLPSILVALFITCLFIISYGYSEEISFASRRLGNLSYVMLALSLFFSHFMCLYVADWLFPLILTDLQLFISHHMILMVFMSEVGKMVMKDHEIGIRARHTSPYFSNFFLLTSFIVIFYLFRLCSKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXZ2</accession>
    <name>L7JXZ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0744"/>
    <dbReference type="HOGENOM" id="CLU_931258_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXZ2"/>
    <dbReference type="OMA" id="GIMHATT"/>
    <dbReference type="OrthoDB" id="10415059at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="257" mass="29401" checksum="EA85699C8E2E5662" modified="2013-03-06" version="1">MSPCGMHTKKKIVSFKKSSTIEVLLTFMLSLVDFVIIYLVYQMVSRQSHIIFVLFTVTLAYICLIYDREQNLILIFMVLLMGAIVYNMDTYTTFGSAPIDEIFESFMVEKKQNYAILAVVSIIFRILFADFLIAHHAVSYTVYLLLFSIFAFVTTANELYRLTITYTQIYIVIGAVLSGIMHATTDLCDFGSLDRVLLVYAAITVFITLYLLDSNGYVIIKNPQEMVYPLPSKPIIFFITANMAIPFLYPVFAHFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY24</accession>
    <name>L7JY24_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0681"/>
    <dbReference type="HOGENOM" id="CLU_1647842_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY24"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="18042" checksum="5CB8BD6628F0D930" modified="2013-03-06" version="1" fragment="single">VEALVTTAAKNDAEPAIFQETPDSSTSELASRDVNNNYVNSATSKELVTGDASFCGLKTTKETDANTEKVRNVVDSPRVALKQNMNIEEKDMLQRTNGPPTRKLSPFAVEYNEKWTAYCDKMIELIDLYVEQYKDGDGNALLKKIEMVKSRFVDSMYQSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY37</accession>
    <name>L7JY37_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993936">
        <property type="protein sequence ID" value="ELQ75647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1400"/>
    <dbReference type="HOGENOM" id="CLU_445221_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY37"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="614" mass="71282" checksum="1BEBB866BF2E55D6" modified="2013-03-06" version="1" fragment="single">MVLSWIRRATILVRYILLFKNDGNNTETSVLICDNLDDVKLGNVFNNIAHISELPIDELSDYDIIKYDLQADILNIFDKKNGKYVISDSVIIQISVNDHNNTDIMNYEHFVIRIPATQHLFMKVIRLNSHGKVEFSDNEFYNTIKHLIIFVDNSSFILHLLVEKLIKDSKLWDRLKTIDRKNNNKSKTDAISYNQFEMNLSNAMMEINNTTYLAVMDNQKNIAFISENGSTRAKTPVYVNLRNLDALFLRPFIVMNGYFLINNHKELYKKYNKSIIEHGLNIEVDFSDLFYSKRRKYSTDFRLGQILGKIINEIIGCEFLTLYSIEKCMFWFKGIYSNVNFNVKSHLIYFIHFEACTFEQNVYLPANLKKLWIIDSEIVNSLILPIGLEEIYLEEINVKEKTKLEIGKKCQVISLKNINGDVNILSITENFSIQYCTNWTLELKKDENDVIVELHIVNVVFRNVESNLCYDKANMTLEDVTLSNGCIMLLHKHVTKVELERFTGLIRISNIVRNESCVIYLDSGTCQLQRTDEGSVQELTLFNANLISTTTTTEHQIDLNDGLNLELSSSVKKICLKNCFGALLFEDWPIFRKIVFEQDNRCPISGQMFQFVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY38</accession>
    <name>L7JY38_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JH993893">
        <property type="protein sequence ID" value="ELQ75976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY38"/>
    <dbReference type="STRING" id="72359.L7JY38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1050"/>
    <dbReference type="HOGENOM" id="CLU_387135_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY38"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="249"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="497"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="714" mass="80401" checksum="9E890BCC2A9F5A0D" modified="2013-03-06" version="1" fragment="single">VAHMIAKKLRLSFTPTAFQIRFAGYKGVVVRAHIPHDLILRKSMRKFNSTYTILEVVNYSQPIECYLNRQIIMILEGLGIPKHNFISLQNEYLMQMYRAINHSLISKYCRIGGVALVDRMSGAVIGRLFREMCAKGRIFVSNGVVLMGVIDEEGVLGENEVFVRVCDDYDEDDGTGKRMKGVGRDKRGVDRRGSECSVDEGRGSECSVDGSINGNNNINPTTNPLNINPINTTNYTTGPTTKSTTYTTNNRTADGVVVGNAIVAKNPCLHPGDIRKVHCVYKKELLHYKNVLVFSRKGTRPTFNMCSGSDLDGDLYFISWDKRLIPRNEHFPQSYQSSSYLSKEHIVTQDMVNFFTRFAKEDELGKISNAHLVYSDIHGITDPQALKLAYLFSMGVDFPKTGYIARLPQNLEPEVYPDFMERGRSYKSGRVMGVLYRRVLFNCEDVGGVYGESAGGEMVNRMVEGCRRRGMYNCRRSTRAYDNDIEGRVRGSETIESNSNSNGIGNGIGNSIDNGNDNDNGINNPTNTSPINSINTTSPINTTSPINSINTNIDSKNLAQLFKLILKGVKESFKVRIPNLSPALLQQASKDYHEYKTDIQKLMVEYSLKNEYDIFLKKVETDTQSACTQRITKFINYYTKRFFMNSYTVNGESVSVRDKALSWFAVSYGRGVGESFYYVCGCDEDMVEYCFVGGGVKGYRCYYNPYVLVRDKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY85</accession>
    <name>L7JY85_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vacuolar sorting protein VPS33/slp1 (Sec1 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0776"/>
    <dbReference type="HOGENOM" id="CLU_781184_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY85"/>
    <dbReference type="OMA" id="HWYFMRM"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="320" mass="36861" checksum="6CB5234864D38F42" modified="2013-03-06" version="1">MMLNDYLCGLTAKATKTLENYNLILSTRKEFLTKNLTNVQILELKEINSNFPCVVHATDEYLISCAQSGSIVFFLTVRSLNTRGVALHWYFMRMTNDLWSMERKTLKEVFVERDTFILTELATFFRRVHINRICCKGAVSKQLGMLLLQQDKVPKQKHRINNLLIFDRTVDLLTPTNTKIQNSITEKQMLSILLTKNGNTEKLNTLLNFYVLISLLKIDMPAIKREMVYTYGEKMVVIFDMIDRMVSINDAHIYIPDLCKAVVNKHEQFYCFDVNEGTDEGGENVVLFIGGVCQKEIDDLKGFTVLTTKLISDDLLKELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYC2</accession>
    <name>L7JYC2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0494"/>
    <dbReference type="HOGENOM" id="CLU_1385050_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYC2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="22174" checksum="026A23A206202F31" modified="2013-03-06" version="1">MFLFTLYCVISCNSPKSEETGESSGSEAIINQQNVKVNKRLKKFSRRVNKSPHQLSISSPSQAYTLKSCEHGTNKSGGEGYNLDMSNLANFYTSSKPTSSKQISFLPSVDNTRESGTQQRRLDYFSLRRNGIACDDNQTFYSDGSEADYKMTFAKRRKRSMHDTSNNIDKPLIVLTNGESMSKKKFDQGNGKTKNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYF5</accession>
    <name>L7JYF5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0652"/>
    <dbReference type="HOGENOM" id="CLU_1267754_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYF5"/>
    <dbReference type="OMA" id="YSIEMVE"/>
    <dbReference type="OrthoDB" id="10404732at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978882" evidence="2">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="215" mass="23593" checksum="4BDDC227515920C4" modified="2013-03-06" version="1">MFIAHALLHFFILVSLIRCRERQKQEEDVKDQSGSVDNLDKNATCQTYSIEMVEEDKNLTGINPEDTEVFQEAKRNGLVPLMSYTMFGTPKAINLNQLLPSNLNALSQTLITNMGNANNDSSSSSPSFTFLGGVIAKTMDKGGSDDDKDKDDKDKDDKDKDDKDKKNEPSKEEGGKGKSGKGQGGAKLIQGMPSLREGLADRDEASEALLMPKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYK7</accession>
    <name>L7JYK7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin/protein disulfide isomerase</fullName>
            <ecNumber evidence="9">5.3.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="9"/>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYK7"/>
    <dbReference type="STRING" id="72359.L7JYK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0625"/>
    <dbReference type="HOGENOM" id="CLU_042417_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYK7"/>
    <dbReference type="OMA" id="GIAEWLF"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013266104" evidence="7">
        <location>
            <begin position="16"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="491" mass="56317" checksum="132A6BCE92D80569" modified="2013-03-06" version="1">MLILLPMILAAQKSACELPSSGSVYLTKFYKENCVHCQNMSPHINEIEDMLMRHDTGIKFKQISCDECDCDALDIVAVPTLILNKGKEEISRLRGYSDYNGIAKFITDNLDVDMKVFSRASPEDGKVIVLYERDFYSGFEGPWLILFYSKRKDPIRTIVADVAKKYSGQLKVGEISENNAVNLTHRFNIQTFPAVIAIYNGILAGYSGKHTPASVFEFVDRLMAPSFKEINLEEFEQLVSKDAKSPKFVVFYSNLGLANSFYRKAAHEYKLRAQIFKSKDPALFQRASIYPKKADEEDAKDEERVILTVFKDNVFHRCPIPLSNPQGIAEWLFNSHFPNVTRITNDNFYTVFHGIKPAVLLLTQNDELVELLEDAANRINTGLPFNDQVMAVLDVNEFSMFLPALLPGLKSPVMVIFDPQRQLFFTRKVRFNSVDFYNDLLTLVNMYFEGKLKPYPYRSSWKKYMFGIIFLFILGFLVSLVSKRKNILKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYV6</accession>
    <name>L7JYV6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYV6"/>
    <dbReference type="STRING" id="72359.L7JYV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0812"/>
    <dbReference type="HOGENOM" id="CLU_1013965_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYV6"/>
    <dbReference type="OMA" id="SHSHICV"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="275" mass="32282" checksum="4236408BDD9A8741" modified="2013-03-06" version="1" fragment="single">VLSNHFIYDVIKILLTSDDHDLVMNKLVELKTNFKTYGKECFVLERMLNKDPEKYTTPEGSPQVLLALKINEHIRKNNLKMPLFKKNDIISYIMGHDGAFLPTENLEINYEYYLEQQFLTPFFRLVGVLKSFNVDAVRRLFNIQKRVVSSLRITTPCCSNPQSQTNFCGTCGAEIDKNFLRNQAIKNLREEIELLYERKAVCPSCDNEQGLFLNCFNCNSSIPRKTRNKEFDDFLNSYRNTFPGFEIDKITRMSEYRTVNLLLYFKDEIERCLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYX1</accession>
    <name>L7JYX1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993896">
        <property type="protein sequence ID" value="ELQ75957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1078"/>
    <dbReference type="HOGENOM" id="CLU_372629_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYX1"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="746" mass="85281" checksum="61B67BC33D008B92" modified="2013-03-06" version="1" fragment="single">MVTINKDCKYLSASYCKCRISLIISTFIEKLELVNCKKIEAIDKCQRMPRVLRLINIGYDLRIVFYEEGTKEICESTNNYKANIGRLLVPSSCNNVVFYRFIGAVDLSIFGLGQLNSTEIHKISFKYTYDNCDGVHILHIYNGIIEQNFCNCSLKYKLLIQNIIIAGNNALVINENCALVKVKNCTGNIIIPKILREDHNLILPVDGSSLIYIRKQPNEKYHMYLRDVTIKVTIFLGPKVENIIMTNVKSDCDAILALNQSIRYFVVSNCDINIYRQVIEVNDNIIKLRTSNVVCKPSTEKIFVVKKFLYIENDQLSGNITKLTVKECEIMQGYKLSIDSSCKYICISAYAGEIISSGLSNTGTVSMQSSKDGRFIFLKDQFNESYSMLLYNCTLTNTIKIQLKVQNVVLKNVSVNDEPRPGTNECSKWSNFFELGDLQSIVLSNIEIFDFRRCINLNYLRLETITINQDVSFSNSLKILELIDVTLTGGGKLRLAGDLKRLHISGETGESLLHQLLDTNITESHVTATSKEKLCCYLKDIDFQCNFCVPEETETLHLRDIKMQKGKILKINRNCRRLEITSFVGVLDITEAKLLQNVVLHNKLPRIVNGQWIYLDSNMSNEYSKDDVPDCIFPNSLKTIVCKKIEHNYSSGLIIGEECEELSIISCTGKYDLSRIKKLRKLVFYPSQNENFFITFPDLCHVKELDMAYNGSLMYFKRLLVSCKNVKKLIIRALTFDFDMFRPPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYY6</accession>
    <name>L7JYY6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYY6"/>
    <dbReference type="STRING" id="72359.L7JYY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0807"/>
    <dbReference type="HOGENOM" id="CLU_130565_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYY6"/>
    <dbReference type="OMA" id="MFRDIYR"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="1">
        <location>
            <begin position="71"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="176" mass="20848" checksum="FF0C399B1411C9B3" modified="2013-03-06" version="1">MNFYFSLTNRFKTFVIYRSTPMKKENDSSTDEESAENNLNIYTLKNIECNALKEYPTLPLYEYPEPNLDTLSPICYSSVQKPELKLELYHEETLFYIFYTYTETQAQIKAYNLLIAKGYSFSTVYKCFILYTGKKVVDNTTRKIVVFDPFYWKKIEKSVVFDKNFVDSIKGIVEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYZ8</accession>
    <name>L7JYZ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993890">
        <property type="protein sequence ID" value="ELQ75987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1039"/>
    <dbReference type="HOGENOM" id="CLU_761149_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYZ8"/>
    <dbReference type="OMA" id="DGPLNRC"/>
    <dbReference type="OrthoDB" id="10618312at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="364" mass="40950" checksum="186C63AE0DA33420" modified="2013-03-06" version="1">MLGMEQNNDVNENNNTIAVDRTDHDNLSLGRKSFGNESEGVLKGAWRRSNGVNKQIKALNYETNAGAGHVWKDTPGQSVILSNTTGDSNTMSISRVTLASAITGILDKRKNFLNNEIRDLMNDRGDITTHTRKRVNHAVENANIGLQNSIERVLEETAEQMIKIAAEVAQQENEQITLILKNCSKQHSEQVKIIVDDAGTQIFVVAQNYSLSDVAAITERIDQENGGIYDLITNKIFENAVTYREHKEIHRTFYEQKDKINDAMHSIVDDNGPRLFLAIADIISDAKKKINEVNLEYKTKEIKEIENTVTAHNDVFINDLTMLFDATLTVIDRLINEAFDNIIININRMIAENNPHSFLTANND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ24</accession>
    <name>L7JZ24_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0746"/>
    <dbReference type="HOGENOM" id="CLU_558012_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ24"/>
    <dbReference type="OMA" id="NTRINDM"/>
    <dbReference type="OrthoDB" id="10552484at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="491" mass="57766" checksum="8C13F26311F88A38" modified="2013-03-06" version="1">MSYQIYKRKAFHSRMTKFRKLDILAKMSVKYNRSEDKMIQEYDNSTKYVERAVFERDEVNNAATLKKYNYDIRYLNDEHMTTKNMTLRNNKLVYEAFKVESRNSPALISQNRNEKDTELSCNANATEIDNERPDDNLYITNKPKKFGSNIVNRIYSAKQKRDDEIYYENAETQMDKIMRTQGFRTDEYSNNSGNIVSNPYYTHVLQEEYKMASLKISDTKYQHASQDVANDATNSDIQSNIYYNNKDIDNMNSEKDAVSFTEFPDSSLYTSSDNTNNTSLYYTDKRSKEQVFRLNHSTYEKNNEEGFIQDRKVVNRYPLCYLYSHGKNSNYMYANPDMPIESDNAARIKVLYPQSKHFQTDQDSEFLVHEFITGNKSKSRTVQELKTLYKNFKAKLRTCDYEEYKNLDYLISIIDELSERKKKSQKNTLSSHAKKVLHSECELRRRTAINLGLLAISDFVDKTVATKRNKKKIIFGALQLILKLKLENLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ57</accession>
    <name>L7JZ57_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0410"/>
    <dbReference type="HOGENOM" id="CLU_2039701_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ57"/>
    <dbReference type="OrthoDB" id="6415313at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="14224" checksum="692CFDC2520D3C63" modified="2013-03-06" version="1">MFMNDTYKKQFLIQYDLNDEYAFRFLYYHLHEHYDITYGSLGGIIDNRRTIDMFDKKNNEFTRPNSEISLSECSGCPSLTNTVSPREKNGRSSSNGYFSDDFALINNNMICHGRSRCMNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ63</accession>
    <name>L7JZ63_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0331"/>
    <dbReference type="HOGENOM" id="CLU_3385061_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ63"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="33" mass="3916" checksum="74C385756D9C80EF" modified="2013-03-06" version="1">MIEFDNDYDLIRKPRFLTTLSSKILPFLSSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZE0</accession>
    <name>L7JZE0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNARE protein Syntaxin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZE0"/>
    <dbReference type="FunCoup" id="L7JZE0">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0233"/>
    <dbReference type="HOGENOM" id="CLU_082505_1_0_1"/>
    <dbReference type="InParanoid" id="L7JZE0"/>
    <dbReference type="OMA" id="VWRRYEI"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="166"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="294" mass="34304" checksum="17E56287B4B64C6A" modified="2013-03-06" version="1">MDEFLGRCKKIEDEIDKLRQYIHKLKVLSNRKANSILSDREETELDNRITVLNNMFKENSKRVKEKLKDMHEENKEISPEDEEFEADTRNNRWQVLTNYLAETIELYRTEQLNHTKEEKQRLKAQFLIAKPDATEDELHDLVNSSEGHKLLEKEFKPGARSSKGILKKAGERNKNIKNIVNSINELVSLIDELHEMVMNSRKIVDNIEIEIDVTRKTVKEAKKDLEKARNYQKAAMYIKYVILFIFALAISFLIIGVILFALAKLFFSSWQGENKNGNKLKTDKNSTAQNDTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZG5</accession>
    <name>L7JZG5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0140"/>
    <dbReference type="HOGENOM" id="CLU_772048_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZG5"/>
    <dbReference type="OMA" id="CYLERRY"/>
    <dbReference type="OrthoDB" id="10456438at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="359" mass="42672" checksum="043A65B7089B1C73" modified="2013-03-06" version="1">MPYQIFHYQKNHPIMVDQGVLYMLPYILPLLLCTYVMCYHYTNLHRLKRNINFPTGNDSFYIVRRNPWSNRMSILYTGNRKEEFKTDDFVFEHDNDTQKCKIIKLNDIKNDDKQLDEELGNQDKLPVDDQQDKNHSYKTSTQFSMGRATTLQIISDIEDIWKRKLQQKPYDAYNFMVTAYTNLFVQLRVRVHNNYLYIYADRSDIVPFDIVYLPEIGKFNFESGNFIDLLNLMNENNTIMEKTDDDTLNTFGVFISNGFLDDHVLLVKKGMIACFRGLNVLFICYLERRYSFGGDTVIIRFKGRKMCTWSMLKNKFLIFVIKRNKIAYKTAREYFESLDKTRLYTTLQPTQSNKEGLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZH9</accession>
    <name>L7JZH9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">60s ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZH9"/>
    <dbReference type="FunCoup" id="L7JZH9">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0162"/>
    <dbReference type="HOGENOM" id="CLU_129464_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZH9"/>
    <dbReference type="OMA" id="FPCHEKK"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="19327" checksum="40A24AB723E30BE0" modified="2013-03-06" version="1">MEKKLQIMPPRAGYYPTDDMPEYIEKILAMKQNKVRKIRKDLVPGMIVVVLEGQYAGSRVVFIKQVEENKAICIGPSSINSIPLFSIDERFLLKTSTILKISDYDLKDVKECSMDVNYENEDVETSELEQRIEGDLLKEIAKIKFMRTYLKTPFKAPENDHPLAFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZJ9</accession>
    <name>L7JZJ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993867">
        <property type="protein sequence ID" value="ELQ76157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0873"/>
    <dbReference type="HOGENOM" id="CLU_2051301_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZJ9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="13923" checksum="FD7EC0F4293CF2F2" modified="2013-03-06" version="1">MGKDATFILAKMIREYLTEIENNTNVKLHIEPNVCIFRQIAQGRILASLLGIISVSDTIEYDLDPQADNQNRLIFIQRIFDKLKAKFINIGFITPMDVIECDINLVFTLMRVLHHQIIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZM6</accession>
    <name>L7JZM6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993817">
        <property type="protein sequence ID" value="ELQ76760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0254"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZM6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="956" mass="110584" checksum="8E3068AAAA137427" modified="2013-03-06" version="1">MNPSYSSRMVLYNITDYLTTTMIYIIIFQSTSGDDSEYMIFYDLEHTNMMKFFKLLQLNPTENKHYSIEQYNADQIDNKDAIFGTNSNSIDIGSETGERKSKRARIERQSACYEHIRLYYRHVRLFEVIRAPFSKNLYQKAVALNLVSLEFGKDDYIDIFKYIFLYLDDNTGLLRRICENIQTNPDVFLNAFKNNIENNPQLNLTQESSINVFDSDLKRGLEAFQRAMNSRVICYLMKNQESIAMVFRRYGHKDEMFTQIPLEDFNLGFLVTHFEVGYQDLKKNFDKVCEAFKNRSYNPKLTLIINESRSINELESVINGEYVLNRDFIKLFQHKFFQLKYVENVVIKTESVGFSNNHRTGNATVLYDCISALKFSVDFKGNKSQQIRDMTICFCNNPNGIYNIKIIDSAHIVFDNIEYSPDLIFNKEWKNFKLSNFVAPTDTTITIKSGSERLELNGVSGTFNLSGTAGFNEVQMSMDSKFSFKTNEESITSLLDIANLHVNTCTTIDNNITNIIIDGIRCKVKVVIKVTSEHENIKIENTVGEFEFEGLFRAQLSFDENTYLNIRNEDISQMSLKLYNCVIDDAISFLGNYSAIELVGLDINSKEPFIINKECQELDIVLCNGVITVPEDTHFKRFEIEFDPGTPNELIIEGILCVDELILRGLFCGESIIENILNKFNTVKYLKIKSLDDPESRIVNLVDYLNNQYDVTCYDEKLIDGLREPMEQITSYEIQCGQIKMYPTVKDFLDAFYQRKFITQICGLTYEGFSMSNYDLQRYLRFARNLKALDINIEFHACALLKHMSPEVEFLNLANSCVPSEQLPSMLGAVKKFVKLKILIMDGAFFTDTSNFSFIPPSTEMLVIRHPDRMRISQTETKGEKVKLRKLYLLKSAEEEIGISQQLLQTLGLLKYYIDMGNLDNLVVVEENMYYEIDTCHFVSLGQYKRSFYLGIGEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZM7</accession>
    <name>L7JZM7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0534"/>
    <dbReference type="HOGENOM" id="CLU_478322_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZM7"/>
    <dbReference type="OMA" id="ASGHEEY"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979017" evidence="2">
        <location>
            <begin position="17"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="570" mass="65791" checksum="85F42773E4ADB3BE" modified="2013-03-06" version="1">MLFIFLLNISAACLSSDEEPSVRHEEAVSNQPTNNTGTTNIDSYKEHVTQRYKNKASRVSTLLKSKSCEVLSATSSKPDGRKKMTWMRDQKDNIKLNHCKSKDKISSIGFYDVLQASENDEDLEKSSTENEAFRRKRELSKNLHRDNFSKSSDCFVTSCSSEFEIEWSPEESNVETFRRRFHITCDKPLGINIPHVTNPNVSMNNKRCAIVRETECPRSRCPLQSSYELPTENASSAQQLVDDTTAQSNIFPRSLLVFTPLQRLLNSRLKQHNNSGSKRKEAEREITQSLISGALKSHASDMSVLDEQSKHHMKQHYIDLTAFQDEIFVMRKLVGCYRENVNSSNDNQVPWNNLVTLEHRLDKKKLLTRLHELSTAVLLIRPMISKDKKSVELHSYEELTQHIKRISELINLLIAKNRKLECFINALYLAHDFLYTILKQILTKRQPNKNSKLMLDAKNQLRKDISNELKSIIDCYRRICTNKTKSKMFEDRAMKIHLFFSEISQKVSGDALEYADASEMNTLLLQITNINQNFRCLMNTSSEICLVNRDLEEIFSRVSQLTNCSEEHMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZP5</accession>
    <name>L7JZP5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993803">
        <property type="protein sequence ID" value="ELQ76938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZP5"/>
    <dbReference type="STRING" id="72359.L7JZP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0062"/>
    <dbReference type="HOGENOM" id="CLU_130038_4_0_1"/>
    <dbReference type="InParanoid" id="L7JZP5"/>
    <dbReference type="OMA" id="IVEYLHY"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="98" mass="11535" checksum="413D0033D5B71894" modified="2013-03-06" version="1">MSEIVTLISSDNKKYEIPEHIANESKTLRVFFDSNRPFIEAIERKVVLPMNSKLLIRAIEYMKYKYQYRGKKAHEAPEFHITDEEALDLLDASVYLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZT2</accession>
    <name>L7JZT2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Integrase, catalytic core, Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993799">
        <property type="protein sequence ID" value="ELQ76973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0036"/>
    <dbReference type="HOGENOM" id="CLU_2759599_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZT2"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="70" mass="8138" checksum="576739A1EA4384E5" modified="2013-03-06" version="1">MVTNPGKEFKSRLVTSFSEENGIEHHVTSTEHSEANGRVERLNCTIREYIRKRSNPKIRQKNDKISLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZT3</accession>
    <name>L7JZT3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0047"/>
    <dbReference type="HOGENOM" id="CLU_070153_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZT3"/>
    <dbReference type="OMA" id="EANNEFR"/>
    <dbReference type="OrthoDB" id="10266194at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="267" mass="30608" checksum="C0868D2D5D69D64C" modified="2013-03-06" version="1">MRKVNTKKDNNKTLDKNANTMEGNTPEKLRSATCERRLNEIPGVKGSTMKINEFYGTEVVLEIDEDEMREANNEFRFLRRGKNEDVNEELLSTEPTECDKMIGGEVSTITSRGELKALEGEIELDDKDAMNDHVSDVPIGQDDAVQSIISVEEKNHREVASCPPFSQKKTQKPKNPKKTKKKNDETLATTFKSFFSSFTPKKKNIKNVKNNTKVVFDTKTKTFKYSDFLKPEMSLDELKMFKGRVKQLIEYFEKLKEMNDHKCEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZV7</accession>
    <name>L7JZV7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZV7"/>
    <dbReference type="STRING" id="72359.L7JZV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0169"/>
    <dbReference type="HOGENOM" id="CLU_136887_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZV7"/>
    <dbReference type="OMA" id="CISECIS"/>
    <dbReference type="OrthoDB" id="2195410at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031509">
        <property type="entry name" value="Mei5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17021">
        <property type="entry name" value="Mei5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="126" mass="15493" checksum="E84D9CBB629A60DE" modified="2013-03-06" version="1">MYFLNVENDERHLYNTLQVDGITFYYYKNSGIDQKKKRRYSDQFRTCHLNYKDIYRKLKILEKHKDDNRDLDTLTTKWKECIDKCITVLKNEFELPAKEIFKAFELKKYGFLLEDYGEYDEIEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZW5</accession>
    <name>L7JZW5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ran GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZW5"/>
    <dbReference type="FunCoup" id="L7JZW5">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0296"/>
    <dbReference type="HOGENOM" id="CLU_028747_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZW5"/>
    <dbReference type="OMA" id="CQIIVLK"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="346" mass="38786" checksum="351F1F44BE35C9CC" modified="2013-03-06" version="1">MLLSIADEGKRYKDTKDVQKLFPKISDEIKTVNLTGNVFHSPALRELFKELKKIKKLERLIASKIFSALPSSELLIGLSIIGEFVDPANLVELDLSENAISTVLPETFVEFLTRADKLKVLRMSDCGLGAIGGKNLAMALEQIKDKSSLEYIDISKNKLDYGATEMGKTLSAFPNLKTIKIQYNSIKRASMDDFIKSFELYFPTSLDLRDNLISVEGCKNLGKYFVSWETEELFLGDCLVGNEGLEAFIAEASKKISKEAEDKSTNNLVLDFSYNNISQQGVNLLESYSKHITVKKLMIYGNDFEDCSALVGHISKNKGRVVYEDPEETEKNVIDESLVEKFAKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZX8</accession>
    <name>L7JZX8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZX8"/>
    <dbReference type="STRING" id="72359.L7JZX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0026"/>
    <dbReference type="HOGENOM" id="CLU_1579695_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZX8"/>
    <dbReference type="OMA" id="KPGWNIF"/>
    <dbReference type="OrthoDB" id="2191269at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979288" evidence="2">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="169" mass="19781" checksum="340A6480D038757F" modified="2013-03-06" version="1">MLPVIIIIFSSLILVFSILRRKSVDTCKSNSTNLDAYYGLKENANNVLKTKALLEAAIANLKQREDNYSKKYIIQQMYNQRLLSPKIWDNLRTLIKDLEYEQLVIEAEAELIKPGWNIFGDASKMLPHQKKREEKMDKENRTRENSFLLKKKETLENQLMTKLMEASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7K001</accession>
    <name>L7K001_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTPase Ran/TC4/GSP1 (Nuclear protein transport pathway), small G protein superfamily</fullName>
            <ecNumber evidence="8">3.6.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="8"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K001"/>
    <dbReference type="FunCoup" id="L7K001">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K001"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0342"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="InParanoid" id="L7K001"/>
    <dbReference type="OMA" id="NACGVEN"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="220" mass="25257" checksum="A03136599A7CD05E" modified="2013-03-06" version="1">MAQQFNQYKLILIGDGGTGKTTYLQRIKEGSFRREYIATIGVDVRDVTFKTNYNTDISFQVWDTAGQEMYAQLNDVYYIGASAAIIMFDVTSRITFRNVETWLRKLRLLTTQNNVNIPVIVCGNKIDLKDRKVNQKYIREHLSRDITCYVDISAKSNHHFEVPFLVAARKLTGIEDLQFVENINLQPPEVVLDPNVIYESPDVMDAVHKAQDMQLPDDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7K016</accession>
    <name>L7K016_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K016"/>
    <dbReference type="FunCoup" id="L7K016">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K016"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0074"/>
    <dbReference type="HOGENOM" id="CLU_1975913_0_0_1"/>
    <dbReference type="InParanoid" id="L7K016"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="127" mass="14140" checksum="BA416E0F223B61CF" modified="2013-03-06" version="1" fragment="single">VPPSSIKICDLQIQKKFAPSMTRMHTNSKGKSQSTLPYHTFYPSHITKTKQEIIDKILTLARKGIPASQIGNVLRDEEGVGQISAITHTTLVKILRLHNLAPAIPEDLNALVKKVHEYEGTFAEVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7K017</accession>
    <name>L7K017_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eukaryotic-type DNA primase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K017"/>
    <dbReference type="FunCoup" id="L7K017">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K017"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0685"/>
    <dbReference type="HOGENOM" id="CLU_026253_2_1_1"/>
    <dbReference type="InParanoid" id="L7K017"/>
    <dbReference type="OMA" id="DAINYWK"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0639">Primosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="8">
        <location>
            <begin position="262"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="419" mass="48812" checksum="48F9195D3E19735F" modified="2013-03-06" version="1" fragment="single">VVIRAVHVYFITFNFFSGRNNLNIIIDPSEISMQKIQKDEFPCRVSFYTELHASTVDYPELIKLTKKRLSILKSIETINDHRIMDLSPNEDELSHFLCRLITCSVPWASQWFIAMETKLFRARLATYNLSEIKNFFYTKYLRRAKNLLVNEKSVFIQDNTQFTLDNAPTNTLTDYQTVHVYFSRAPELVRDCKVELKKGYFVLHDANMAAILANEFREYLRGRMDSLKANTNLRNDERFSDLAVDLFSVPQKSTGQLKSILDCAPPCIDRIVKRMKHDRHLKYNDRQILIRYLKDCGLPVNDSIEFLRSNFSCDPARFDREFVYVVRHNYGLEGKRANYSCYTCPQVVAMGACPFTSKCVISDYLSEKGFQDIEDVICGEIENRNYLKGCSILLKHKRRSDDDIAVTSPFVFYSSFQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7K019</accession>
    <name>L7K019_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Nucleotide-binding, alpha-beta plait, RNA recognition motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K019"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0690"/>
    <dbReference type="HOGENOM" id="CLU_1735927_0_0_1"/>
    <dbReference type="InParanoid" id="L7K019"/>
    <dbReference type="OMA" id="HVYNIPR"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="75"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18184" checksum="65203D9CE758AEBC" modified="2013-03-06" version="1">MLTYIYEPNHDRINKRKTMKLFGTTAASLIGTRVSTKLSSPVFYRHDQPQEVAPYKYTPAYKPTNEYIAPKSMPFTLHVYNIPRNINKKSFLDVVSKRVNEPIFHCNFVNDRERDVFLGVAYLRFKNEESGRKAMKALDGMQMGDLIIGANVAKRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7K093</accession>
    <name>L7K093_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Structural maintenance of chromosome protein SMC5/Spr18, SMC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K093"/>
    <dbReference type="STRING" id="72359.L7K093"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0195"/>
    <dbReference type="HOGENOM" id="CLU_973816_0_0_1"/>
    <dbReference type="InParanoid" id="L7K093"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="71"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="286" mass="33903" checksum="8075313D8FE19C50" modified="2013-03-06" version="1">MNSKKKWLIYELEKKEYLILKANSVKIEGEIKTIQKEMSEYDNKIKSSSDSKEAKDHARKLADIKQNNVALERFAERIENYMHEKEKIKVDLKSNEKKKECALEKVDALEMERRNNIEKLEGFKLPSKPSMSVNKDFDKMEQEMMELKQELAELYKQGCKISSEVEELTRKKNLIVDIELRRLEILKNYHKDTYTAVMWLRNNKDKFRDEIIEPCILSLSLKNAKFINEIEGFLSYQALTSFICKDFRDFELLMKTLKDKMKLAINALNTISRLIRPRTQESISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0G7</accession>
    <name>L7K0G7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0G7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0423"/>
    <dbReference type="HOGENOM" id="CLU_114374_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0G7"/>
    <dbReference type="OrthoDB" id="10293110at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="194" mass="22760" checksum="FB581B4A41B732BA" modified="2013-03-06" version="1">MGKGIMDKISELELGRFIIDQDNCKSLKKLKNLKILRIRPEKITNEFLYNLPPSLILLDTINFSQGIIFNTEKYTIKSSIIVPQHQNIKILSVSVDFLYNVRYLSVMMPSLDILVVQYSRSITDYFPVQKSKIKVRELLITCNYTNETTSQEEEMILFIKNIKFYIDFELLKYIEFASLPVSVFFNPKTLRVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0H5</accession>
    <name>L7K0H5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0268</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Water channel required to facilitate the transport of water across membranes. Involved in osmotolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993821">
        <property type="protein sequence ID" value="ELQ76742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0H5"/>
    <dbReference type="STRING" id="72359.L7K0H5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0268"/>
    <dbReference type="HOGENOM" id="CLU_020019_3_4_1"/>
    <dbReference type="InParanoid" id="L7K0H5"/>
    <dbReference type="OMA" id="RAFLYWI"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019755">
        <property type="term" value="P:one-carbon compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665:SF9">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="252" mass="27851" checksum="FDE6C4118C52890D" modified="2013-03-06" version="1">MPLSIQYSKIQSYVAECACSFIFGFTVYSAILTTTLKNMVAGPILVGLSIGFVSIVIIFLFVDVTLAHFNPAITFAAIVFRRIPIISGFFYIIAQGIGFMIASLVVQGCFPGKFEPLMNIIRPKRVNDSTTGEMICIEMFLTGILVFSVFVMAINPYKKQKDERDQRELHIDPSESKIPDRSRFAPIVIGLTLGFLGYLGGSTSGGAFNPGIVWAPVLFSGHWGDSWKYWVGEFVGGCVGAFIQIILFYPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0J6</accession>
    <name>L7K0J6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0J6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0171"/>
    <dbReference type="HOGENOM" id="CLU_279009_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0J6"/>
    <dbReference type="OMA" id="HIEECES"/>
    <dbReference type="OrthoDB" id="10416744at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1131" mass="130032" checksum="E09EEF0E454EF4AD" modified="2013-03-06" version="1">MGEGPISGDMSNKSALGKQKQIIYRAVPANSFVSGGYKKGAAAKYKMKEVPRYENDKKLRAGKSSLERNCAGCTCGREGIRAPEDALKVHTDSEGTQAFLNARENGCCKRCANKNAVSIGNCRSSVNILLPDPGMESPSTCKENALFNKIYAQHINRDYTNVMNQIQERSISRASAVSEAEIAEIVAASRQPEEHAHVVHDGHSNYFARRGTRIAEELRPEYVPLDQPSCTCESSSYEYEGYYTDLGHASEYESVEEMFRSSYSSDETPDPKIWYNRQISSKQKLKIDKLNVLSTKKDEEKVILECEDSSEDERGLEYERAATKDAGTGMQHTASKEINTAGDKESYRYLDRMGIKKEETVPVGCFLGNGNRGDDERRSNKTDEAAMLSREEMEAQKEQLKRAYQREDQNYDKDESQVKRAYQREENQNYDKDENGRVIQDKEIREASSKENDRPVEKELMEQKESTRADRQRDDHLDGRQQEYSFMLADDVVQNKNMLLERIKKKFSSKLSGPDRMNNKSFIIRRETAVPAENEENQGLSKFIDEHPPGENVKMRGMNRNNNFIRRYDVSDQNFVIDDTAKNTKELEKKFVKCMKEHLKLNEGVLSAGVIGDQRGSNCLKNTFVQLLNTYTAASINQTISEEMRSRAKCRERIARMGENSEEMDEKVYAAEKNLLLHNDSFYVTALENNALENKKMQINVKTHNFKIVIKKERLHVDEQVEVSRGDSSKMLANAHDEKTIYLNNFSQNDISGGIKEVETKIFNLDEQIRREYTHNKFEVPRTDVKREDSVVEVCCMADDQVAQESNRELNTSITEYRANTIGVDAFNKEEVKTHEPKVIEEEAVVVANEKGLADVVIAENAENIQTVDATNRRNAGESTEGVFFRNVIGVQIVENPERELEKELRQRCRTQYVEGSEIKSIEVPVTEKKVFSLYEPYHDYNFERLFYQFHIEECESLKEFGHANIIGKMHYRSETNFFNFNWAKLSERKLFCYKPEFSYIRREESDLLSPSLNEKFHALDFAVELEGAKLFLYSAPTFTLQNAIKLIKCKNISEFMDITNFHVVNVTPKGSKYLVDISNDQIRKQFMIKDLSFIVESSGVKYFFRVETLKAFINWLACLYMRIHNLKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR34</accession>
    <name>L7JR34_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3129"/>
    <dbReference type="HOGENOM" id="CLU_2924363_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR34"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="7212" checksum="19C407C8DA67AFBA" modified="2013-03-06" version="1">MVYAVLCSHVFYVLMTIEKNNKTFLENVEIRRARVVMVGVGKDAFNEKRTRVLYFVRVNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRC5</accession>
    <name>L7JRC5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_3270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRC5"/>
    <dbReference type="STRING" id="72359.L7JRC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3270"/>
    <dbReference type="HOGENOM" id="CLU_716103_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRC5"/>
    <dbReference type="OMA" id="HEYIIGD"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ73830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="389" mass="46011" checksum="3B55755FEDE58228" modified="2013-03-06" version="1" fragment="single">VERAMNNTKDHSGIVNVLSLLLALFLIKEYYAMFDVRNVKNVYSLLQIRNPPFLCAILILVGARSVLQFAKANVACLIVSEILIYYLIYTRTYGIVSCNTALLSMINFMKLYSYIAETRKNDAVTRNEPPIKENNTNTCANVHQHERITEDRRNDVPAPEFTYFIRFLFLPTLCFLDATRYRKRSVSALFYNLIMASLLFSLVNFLVAFYIIPLLECYTIRDFVTDLTVFVRISATSFVIWVAMFLFFFKYYLSFLAECTNYENKIFGDWWNARYFRDFWRLWNIPTHEWLRRYVFFPCYRVIESKWTCTLIVFVISSILHEIVYILTFKKVGVVVFMSILSQFVFIYLEQVLFSPGNLLFWFVFCFIGQPVFLLSIRKRFLEIVLIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRG6</accession>
    <name>L7JRG6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vesicle coat complex COPI, beta' subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRG6"/>
    <dbReference type="STRING" id="72359.L7JRG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3052"/>
    <dbReference type="HOGENOM" id="CLU_022265_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRG6"/>
    <dbReference type="OMA" id="YVDYYPQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="522" mass="60714" checksum="8E34F6FCD15A2005" modified="2013-03-06" version="1">MDIQVVDDDRLLSCSLDMTLKLWNYKTNVLLMTFKGHTRGVNAISVYKNTFYSVGDDHCMRIWCNNACRVKEGISDKNIDHIKVTDELIVTGAEDGYYKIYKRQGEQLEHSVFVGSRVWDSWVEEDAFYVATDSGILIYDRQDAKVNRYLVDRGLLHIKADSVFLNDKEIGKINFEVERVSYNNKIMCMQKKDGFVVFSYLGFREKMRDSGKALVLNEKLVVSRDNVMIIYDDLEKETQFKILYGDFKLYDRFIVNYSSAGFVIYSYSGETVVKGTADIRDIFIIGNKVVISNECTGIIDIDGVKKSTGRLSLHKVMDMPVEYGHVHHDVLYFMSNNKLYYLLANGFFSMISYVNNIFLGIQNDCFCFFDKKLITKPIDEIIAWQCDEKKDKALEGREKECLSYLLKQKEYELALRLFDCKFEIYLQMNKLENAFKVARTPTEYKMLGGLFMRQGKFSKATEAFRLGGDDEMLFLCDFLGKRKFMKSGDNDSFMKCMYLKDKDGMRRFIVGSEFEAAFEKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRK3</accession>
    <name>L7JRK3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994097">
        <property type="protein sequence ID" value="ELQ73920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3160"/>
    <dbReference type="HOGENOM" id="CLU_2122791_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRK3"/>
    <dbReference type="OMA" id="KQKSKWQ"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ73920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="114" mass="13652" checksum="03B81507A96DDDBE" modified="2013-03-06" version="1">MQYDLHYLQAYTPKYEQPSQAHINALLTRISQLPVKKHENTKLAILPAPVLVLPHKKCEVPKQKSKWQLFAERKGIRKRRCREVYDEKNDTFLPRYGRFSVSKMKKRMPKEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRW2</accession>
    <name>L7JRW2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U3 small nucleolar ribonucleoprotein (snoRNP) component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRW2"/>
    <dbReference type="FunCoup" id="L7JRW2">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2876"/>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRW2"/>
    <dbReference type="OMA" id="FRIKHEQ"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="178" mass="21368" checksum="FA2AED3001AE57B1" modified="2013-03-06" version="1">MRHLKYHEQRLLRKTNFLEWRDTDTKNEHYYISRYYITRREDYYTYKKLVRIIRTLSESIASLPDALKEKYTKVLVNRLYSHGLIANKKLVECAKIKIENFCERRVPVLLKRNRMIENLGDAVKFVEQGHVRVGNTRVNNCSVLVSRGMDSFVEWVDGSKLRRKIKEFNDEVDDYEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS03</accession>
    <name>L7JS03_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3266"/>
    <dbReference type="HOGENOM" id="CLU_1994340_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS03"/>
    <dbReference type="OMA" id="KKLAHIF"/>
    <dbReference type="OrthoDB" id="10379493at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979088" evidence="1">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="17195" checksum="34C16E7A3C876D28" modified="2013-03-06" version="1" fragment="single">VSRCTCLYLIRTILLIISNSCEPCMADQFNKIFFKKLAHIFDKYKNKDDTFDEGIDIINCNSSELDEMCGVKTLQKNNKHELYTSAKKTANEYEFAQDYEDIHFSRINRRIGKVIVREKACSFSNVYERRCVNNFDDVFNSVFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS45</accession>
    <name>L7JS45_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="9" type="ORF">THOM_2799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS45"/>
    <dbReference type="FunCoup" id="L7JS45">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2799"/>
    <dbReference type="HOGENOM" id="CLU_077754_5_0_1"/>
    <dbReference type="InParanoid" id="L7JS45"/>
    <dbReference type="OMA" id="MENTCFR"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="172" mass="20636" checksum="778FB9610851AAA2" modified="2013-03-06" version="1">MNDQTYTNQQWLETNPLTVETVLTYFSFSPFYDRSSLNEILKMQTQFTNFLDFSKKLTELNGVKYLIEQKGDIFFIYKIHKQKDTEELLDFYYVFFGTIYKGATTNSIFRTRVFNFLFFLNESLPKYLRRRRFSAVEGFKMKSDEEINTGNAEEMIEDKEIAEYVMRDIYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS89</accession>
    <name>L7JS89_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PHD finger protein BR140/LIN-49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2790"/>
    <dbReference type="HOGENOM" id="CLU_356855_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS89"/>
    <dbReference type="OMA" id="IRCAYTE"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <location>
            <begin position="99"/>
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        </location>
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        </location>
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        </location>
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            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
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            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="786" mass="91306" checksum="183E821428DEA22E" modified="2013-03-06" version="1">MINQPREETDYHKIYPDLDVNTNLLVINELPLTDKQTCATPAAPSSTAEYTYRPVDFNNVDYNADSYDLAFLKEYALTMPVSLFELIIDRLEKEWYFFKHTLARRTFIPFESNVGVCNVCSHSNVRVDNNLVYCDGCNLCVHQECYGVPIIPQGSWFCKPCTYQLGPLYCRFCVKTGGAYKMTSTMKWGHVVCVLWNADLYFGNEVFMEPIEDPNRTNAHRLKHSCSLCGSTKGMHIRCAYTECDVWYHVTCAIEHNLYMDQSNVLTYCGAHDPRRSIRYDDDLEGYPALEKLPRIRRPVQLAQPKKSLLLYVKNMRPFGCTYLMDRLYSNDLCNFSVGKDEFVCVMRYWCKKARVLNLGPLIPYLYFDVNGGIGWEWYEKRRLFCCGRGVVGKGKDEKINDEAEGRTSVRKDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKRTDKEDENAVENKNEEKVKNVIDEQILKHSDSRNVQAQKHKRRKLPADYELDTCHAEHHERRAHNDTTQNTDRSLITCTSVFRRADDTTPYPCYSNEERVKYQEWLKDVKQGCSHKKMGNMSRDDVIYMYAPVYGLKRVVKALIERSDAQMELINTNREIYEILYARKRYILKKVMSILDRGEYVLFKERVTEDIAPNYFDVIREPMDFEKVYSKVERYEGVPQFFDDLRLIGTNCVTYNQQVPYFVALAERFLEEVGQLEQHALQMLDEDLEYDSIAVTNGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSI8</accession>
    <name>L7JSI8_TRAHO</name>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4429" checksum="F577BCDDC9EF3D1C" modified="2013-03-06" version="1" fragment="single">VLNLEYKPFKEVEGKNRESRHCRRSLRLYNIRLSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSM3</accession>
    <name>L7JSM3_TRAHO</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
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    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="18519" checksum="B8CE8062316A2700" modified="2013-03-06" version="1">MDVKHSNKGGGTQRYRSQNVIDSKFITVLFRKYRQLNVKKVVIRVERDGFFIYLQIWMKGTMRTVSTERADKIILERRIESLALHRSRKRLGKEMRYADMNPIERKIVSLTAKKWRILVSIKKRREAERATKDRRGKPRHRLRTHKERSVDVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSQ2</accession>
    <name>L7JSQ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3028</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSQ2"/>
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    <dbReference type="HOGENOM" id="CLU_2832981_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSQ2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="8200" checksum="A79C57AA93174FAF" modified="2013-03-06" version="1">MDDKELEWFINMNRRSWCYDQLTRESLRNGKLRMKDRKNTSQKVDEIVADKMRQERRAIPWKKRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSR2</accession>
    <name>L7JSR2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994037">
        <property type="protein sequence ID" value="ELQ74518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2562"/>
    <dbReference type="HOGENOM" id="CLU_2819742_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSR2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="67" mass="7881" checksum="C69B35110F1530F5" modified="2013-03-06" version="1" fragment="single">VTARDVVPLEEWKGDVKTAFDVDGIWMMLEPSELKCVRGHLNVRMENRYRGVQFFNRQAFVLIERSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSR8</accession>
    <name>L7JSR8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Splicing factor U2AF, large subunit (RRM superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSR8"/>
    <dbReference type="STRING" id="72359.L7JSR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2569"/>
    <dbReference type="HOGENOM" id="CLU_781183_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSR8"/>
    <dbReference type="OMA" id="ELICANL"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="353" mass="41147" checksum="3C0F7A63987C03A7" modified="2013-03-06" version="1">MPLNNQFNTAGSSSDRSNDILRGIEHIDELICANLRMVYDPEDEIDEYNLVPQILEVVNTQKKYVLDEIEQRKIVVKNGNINEIIRVLEKNFAAFNYRRNSSGDIEILFDTQEDADKCITMKIEGLKFSRPVKYFVTTRSKLIEKPLDEKLLLGPLKTEDEKLKRALNEISDLCMFRRCYDFVKNTPTDYFVFSFRNKNVAENLCKFLSFVNVDERMLIVCRFYDNVSIVNLNEMFNDRFIVSGHLIAAKTETRVVQILNMFLPGEISHFQMVEEVKKMILQETGNENIVNVYMPLSLYSKAYCSCEGRVYVECKNINAARNVFRRLGGLIFNGRVVITSFFPELHYEAREFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSS7</accession>
    <name>L7JSS7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSS7"/>
    <dbReference type="STRING" id="72359.L7JSS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2579"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="L7JSS7"/>
    <dbReference type="OMA" id="LIMSERR"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="58"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="254"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="481" mass="55736" checksum="11D445091E6E8CA9" modified="2013-03-06" version="1">MAKAVVLDETEHVAVIDGFDIQPTKEIKFDVFIRDINIIARLEKDGMLVMKEVQYKAYDKVFNGFNVMIQSNTGSGKTLAYLLPLIMSERRGLIIVPTYELATQTYDIAKAFTSRIGINAGQLCIDLRADIVICTLGKCREMYMDDRVFCCIDEADRILENEVFLNGCFEQFVLVSATMDSKSILKRLIRKCSKSMKIRTKTKNNIDRIIDIDSSTDTKRILTKNNEEIIFYRINIIGEQIVKEFYINVEYSYKLFIFIEFLRKNRSKKMIVFFNTINSVVFYYNLLKRMNFSVIAIFGRLNQRKRKEIMEKYETVGGVLLCTDLMSRGFDFKSVDLVVHFEPSFTLNNYVHRKGRAGRNRRGKSILFLSNAESGFISEVTNIKEVMYLKKKFVVCDQTSHEMVIKAVSSPQNTYSGFLTHKIYEMVKNDVILHKMAVDALKSFLRIYEGNTGEYFNVNSLDLNDITRTFGMKKMPRIDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JST2</accession>
    <name>L7JST2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 9">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 9"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JST2"/>
    <dbReference type="FunCoup" id="L7JST2">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JST2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2584"/>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="InParanoid" id="L7JST2"/>
    <dbReference type="OMA" id="AWINDKG"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="340" mass="39240" checksum="F4820A5510E72E6A" modified="2013-03-06" version="1">MNKLSKEEKFYLITRNLKEILGSDDLRDIIEKKDPSVYWGTATTGRPHIAYILPLLKIKDFIDAGCEVKILLADIHAFLDNLKANFDEIDSRTEYYRILITETLKMLNVTKGFTLVKGSDFQTDKNYTLDLYKICSLTSERDARKAGASVVKQLDNPLISSLIYPSMQALDEQYLDVDIQFGGLDQRKIFTYAMKYLPKLGYKKRVHLMNFMVPGLNGDKMSASDINSKIDFLDDGKTIRNKIKKCFCEEGNTDTGLLPLMKHVIFPVFEILDRKVTIKREDGTELEFGNYEMLEKMFAEKKVHPQDFKIALSEMLNTIIEPVRNEMVKHSELIKKAYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSW1</accession>
    <name>L7JSW1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994072">
        <property type="protein sequence ID" value="ELQ74126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2954"/>
    <dbReference type="HOGENOM" id="CLU_1603910_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSW1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="166" mass="18827" checksum="B6B8FCD188655345" modified="2013-03-06" version="1">MDKPAPSFVYKVKQKPKVIKSSEVKPLFQFTRKRKEYEESIRCDVMDSKFFVDCEAVSNLAGTTGKGANVSNGNVVRRKEALKQKMSSRKIKDLMGDVTAKGDRKTKRSVEMRKRAAKGAGLERDDKQEEENNRNNERELQTKMLITKEKAVVASQMDRGGVARPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSW3</accession>
    <name>L7JSW3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2693"/>
    <dbReference type="HOGENOM" id="CLU_3130052_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSW3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="6004" checksum="9092A43912273FF6" modified="2013-03-06" version="1" fragment="single">VYVIKNPRDLRSIHNVVLWIVKFKLLKMAGLSFTIEEYYETSNERLYTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSW5</accession>
    <name>L7JSW5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSW5"/>
    <dbReference type="FunCoup" id="L7JSW5">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3301"/>
    <dbReference type="HOGENOM" id="CLU_181948_2_0_1"/>
    <dbReference type="InParanoid" id="L7JSW5"/>
    <dbReference type="OMA" id="KRELKHN"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="51" mass="6249" checksum="4BB6D4BDC4454D90" modified="2013-03-06" version="1" fragment="single">GAIKTRLHKIRLAKALKKNRSIPPWKRELKHNKQEFNFKKRSWRRNKLKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT77</accession>
    <name>L7JT77_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase</fullName>
            <ecNumber evidence="2">3.1.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.2.6" evidence="2"/>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT77"/>
    <dbReference type="FunCoup" id="L7JT77">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2439"/>
    <dbReference type="HOGENOM" id="CLU_030571_4_5_1"/>
    <dbReference type="InParanoid" id="L7JT77"/>
    <dbReference type="OMA" id="TPCHTED"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="241" mass="28214" checksum="956C4A3A5D8EAC1E" modified="2013-03-06" version="1">MAPKHKILGIYVGNERNLMYMVYNEKYAVAFDTTDVKILEHALKIEPRSMLMEKEDVLKSEAKVDRKLLAVFTTHHHWDHSHGNDDVMLLTENVFHGKNLEEKVYKFEDFEVFALSTPCHTEDSYSFLIDDYLILGDTLLYLGCGKFFEGTAKDMKACFEKLKKNVKPEVICCYGHDYADTGYKFAREYFDVPEEYRLKRLLTFGEELAYNPFINFQKLVDRKAIKGLTELRTIKNRYKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTB5</accession>
    <name>L7JTB5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">DNA repair exonuclease MRE11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">THOM_3095</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ74002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTB5"/>
    <dbReference type="FunCoup" id="L7JTB5">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3095"/>
    <dbReference type="HOGENOM" id="CLU_009535_3_4_1"/>
    <dbReference type="InParanoid" id="L7JTB5"/>
    <dbReference type="OMA" id="ESCMFNA"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="18">
        <location>
            <begin position="258"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ELQ74002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="555" mass="64023" checksum="B2E1DA96E279A5D7" modified="2013-03-06" version="1">MKILITSDNHLGYKETDPLLSLDSFNAFEEVLQGGKECDLMIIAGDLFHNNRPSRFTMYKTIQLLKKHVLGNKEIRITANKRLNYEKPNINISLPVVVINGNHDDPCGFGSLSALDVLHQTGLVNYVGKINNYERIVVEPLIVKMEQTVALYCLSHVRDSRLYKLFSQNKIEFLKSNADINILIVHQNRIERSRNDFLPSEFIPDFFNLIVFGHEHDPLLFERNEQTYLQCGSTVRTSLCEAETGKKYFYRLEVAESIKIEKIELKSVRPFLFDTLSTGTKEVVQSKLEEMLGGVSKCEKCEGEAFCDACKPLVRLRLEDDVSFNKLHLQNVYADKVANPGDIFLLIKKRKPVVIRENKPVHAKCTDIYGIVHSYLVSSNLGVIPELVFLDKFREYVEKENRGVFQSFIDELEEHRNGSIVGCEIEHFKNLKESMNRKFVRENNVHVQEYEDVALDPAVGSLNENNSSLIYDMDDPRARHRANLEFVGAEEAVKRSKVHENVRYTLSEEQINNLDLVEYARDNNLIKHDFSKKTAQRDEDEEEKNKENFTFSNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTG4</accession>
    <name>L7JTG4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2371"/>
    <dbReference type="HOGENOM" id="CLU_654174_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTG4"/>
    <dbReference type="OMA" id="KKYFIRP"/>
    <dbReference type="OrthoDB" id="10465228at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="419" mass="46835" checksum="00B2540FF7C4FEA9" modified="2013-03-06" version="1">MVKTSKICGVKLHKREIFVASATEWHNSSTYSHETLLKIFSTIKDASDAIIAKMDSSEMDKNHGLRRNVNFVIDMNLETEIVTRADDEGSKKYFIRPERPFERDVGGLVDDKDFETELTEDEEEFLNGRSDNTDEEVRGNVAVQGACQNVMTGVGGKTTNDENVKAAVSTENDAKTVVDVHTAQSIETKKVAAKDQHEAVLTGPRTTTMVNTSMEGRNNAAVSIDRRDALDASLNHTKNRIIDETVKLCGTAVTDGAVIDSIAIQKNDTKTTSVTSTSMPSTVKKSKSAHSKSNKDLSNAKKTENKSKKKLQTAKRQRLSDDRRPRRNIFSNFKPTLLHTPTEDEINEYYADFFIIKNPLKSIRCGDSPYVYYEVTEKKAVKKKITIRLKGKKKSIKDELIGKFFVSGDMSDEGEDVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTM8</accession>
    <name>L7JTM8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTM8"/>
    <dbReference type="FunCoup" id="L7JTM8">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2291"/>
    <dbReference type="HOGENOM" id="CLU_025360_1_0_1"/>
    <dbReference type="InParanoid" id="L7JTM8"/>
    <dbReference type="OMA" id="MTIVHHI"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="496" mass="55294" checksum="FA221BA879F70B6D" modified="2013-03-06" version="1" fragment="single">VSNYKSTPSRSCMKTMHKLAFIPLYLLSSLVSTLLNKHITTALGFHPTFLLLLMQSVIIVALLVFLKTVNACSFVLNLRCMLYWIPAAAFMVLMIFSGLRALSHLSISMFTLFKNYSVIVIAVFELVLFGRAISRLSIMCFVMMIISGMLVDYSETVVDRAGYVWICINVIASAVYVIVLRMTIVHHIGVRRSETEESTSHGAERSGVNGTGFAGMNQTDKGLLRKMLHGTIESRRAGEKSDDVGTAYSDRACTTPVIVFCSEAARRVRNNRIGGYVRMFEGMGDRRPEQKPSKGSTEENVQGVNVCDDRMVKKATERKTKRKNVKYRPNDFEHLVYSQILSIPFLFLLSLFFDNYASIASFKRVLENDILSSPDYVDTFLLNMEKVSDLAIVHNILIIKAFIGDLLELSGSAYFDDKVFLFIVLSGVSVFFVALSTVWCLRSLSSTTLSMMGATNKIIVSMSGVFLGERIGWIKAVSIAVGGLASILYVETIRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTP8</accession>
    <name>L7JTP8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription initiation factor IIE, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTP8"/>
    <dbReference type="STRING" id="72359.L7JTP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2266"/>
    <dbReference type="HOGENOM" id="CLU_056967_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTP8"/>
    <dbReference type="OMA" id="FYEPHHV"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor IIE subunit alpha N-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="348" mass="40808" checksum="209A063243974FBD" modified="2013-03-06" version="1">MDMSYEPLMQKLIRHTLRLFYQPHHCVIMDILSEKLLLRENEICSAMKMLSKEFNKLIVKLKEDKLIKQESKIETTIDGRQLLQQIYYIDYREIKDIIKYKIYKMSTEINEHLREQQRQIGYVCSECKTEYSVLEAQSLVKNYRFICPDCNIELVENKNTEVDPHELHTLMMNDLKDIIDMLKQADNYNIPTIDYFQALEMKKNKEAKTGVVVNKTDDNMKEIDDAADTKGYEASYTFGELSEIDKEMATHETVSGEEPGNVVQDEISVRKDECFVTDKSLEEEIFLNTTRSDDLEKSEPRPADVHDEIMVKVGGVAKVFSAVTEEDKEKMTEEEYETYFEVFLKQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTP9</accession>
    <name>L7JTP9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTP9"/>
    <dbReference type="STRING" id="72359.L7JTP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2665"/>
    <dbReference type="HOGENOM" id="CLU_193154_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTP9"/>
    <dbReference type="OMA" id="KCAFINR"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7294" checksum="0F3393932F042581" modified="2013-03-06" version="1">MMISQRICDLSRKPISSVDKASVQLTFVNLDENGRMTDELTVLNVCGALRKQGKADGLIMEKFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTT2</accession>
    <name>L7JTT2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Splicing factor 3a, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTT2"/>
    <dbReference type="FunCoup" id="L7JTT2">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2228"/>
    <dbReference type="HOGENOM" id="CLU_1526231_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTT2"/>
    <dbReference type="OMA" id="HTNESSY"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SF3A2" evidence="5">
        <location>
            <begin position="86"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="176" mass="21381" checksum="FFF66BE33A483125" modified="2013-03-06" version="1">MTEKHTKITPAIIKENRRKRLKQLINRLHDLKNDKYLRINHLGKIECKLCYTTHTNESSYVIHRSSTRHQLLAEKQFKRDRMLNNQPKYKMYNVRDDVYQGFLVKIKTKHDVMYKIVKALEQNVELVNQNYNYLVFKVREYDNIGLRVDVSEDYKIIKHFDGYNFKLQILYRIKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTX2</accession>
    <name>L7JTX2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_2311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTX2"/>
    <dbReference type="FunCoup" id="L7JTX2">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2311"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="L7JTX2"/>
    <dbReference type="OMA" id="TRFHDFK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="57"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="239"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ74750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="407" mass="45987" checksum="20932D2794D18A94" modified="2013-03-06" version="1">MAVPFITEEKKEENSIDDKGILNIYERWEDYDLKDPLLRGIYSIGFETPSYIQKTAIGPILQGRDIRAQAQSGTGKTGAFAVASLQRIDETLPATQVLVLCSTREIAEQNAARTTEIGKNMGVSVPFLAGGFNVGRTREELARNPPIVTGTPGRVLHMISTGDLKTDSIFLLIIDEADEMLKRGFKDQVREVFMSLNREKIQVAMFSATWDKSEMEVADDILRDPIIIHLRHDEQTLKGIDQYFVNIGSKPSRGEDIQKMEVLLDIYRRSEVGQSVIFVNSRSKAKFLYEALKTHKFPCEVIHSDLTQNERSDVLRRVRNGECRCLIATGLMARGIDIQQLSIVFNFDLPKGLDKSSYIHRIGRAGRFGRKGKAINIVYQDEMECIKELEGFYSTMISPLPNDFNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU28</accession>
    <name>L7JU28_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
            <ecNumber evidence="1">3.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EC" id="3.8.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JH993999">
        <property type="protein sequence ID" value="ELQ74988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU28"/>
    <dbReference type="FunCoup" id="L7JU28">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2072"/>
    <dbReference type="HOGENOM" id="CLU_059493_1_1_1"/>
    <dbReference type="InParanoid" id="L7JU28"/>
    <dbReference type="OMA" id="NQVESEC"/>
    <dbReference type="OrthoDB" id="2195201at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018784">
        <property type="term" value="F:(S)-2-haloacid dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="271" mass="30734" checksum="00E7C435AEF207C5" modified="2013-03-06" version="1">MENRSIEKDQSALLDASGDEYSIGMTTTHFIAMNKQNLEKYKQIITPLGNETLIVCDIDNTLYHPSAGVEDLIDKKLVEYLTTVTSSQEEALACKNRYDDVYGLTVYGALAELDVELDFYSKYITKTINYEEYLKKDPVLRDVLNRLDCRKICLTNGDTIQAKGILDALGLTECFEAVVTIDAAVPFFIHKPTKESYQFVDELFGVSSPKNVLFFDDNIKNIEQALAHNWIAHHVQGNIHIGDMIGKAAEMLYMRTDRLLQDNDEVEVKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU34</accession>
    <name>L7JU34_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU34"/>
    <dbReference type="FunCoup" id="L7JU34">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2824"/>
    <dbReference type="HOGENOM" id="CLU_1344083_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU34"/>
    <dbReference type="OMA" id="HIEIRNC"/>
    <dbReference type="OrthoDB" id="10412357at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="204" mass="23778" checksum="61FD9FB3853ED855" modified="2013-03-06" version="1">MRPKKSKKIRKALQKLERSFAFRKPFQLLLDDMLLAYLDKVNFPITVINNTFNYPKLFTSRCLYKKCYGKGEKSDNSVKENDKHESESVKSKLPEITEALKEEENEHKTQSVKLQGNQTSKTAMKFAKHIEIRNCLHKNEVTPAECIRKFVKKSNANHYFLGCILNNNKYKGLKNVPLVIFRRNGTLLLDTDSFDKKESQDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU52</accession>
    <name>L7JU52_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Rho GTPase-activating protein domain, Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU52"/>
    <dbReference type="STRING" id="72359.L7JU52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2111"/>
    <dbReference type="HOGENOM" id="CLU_863779_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU52"/>
    <dbReference type="OMA" id="KFSYTRI"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="81"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="327" mass="38540" checksum="352F1AA3ADF8457D" modified="2013-03-06" version="1">MNEENITEYLVEHIESINDMDTPVFERYKAQFLLDNREIIKKYVPFMKRFSICMRNCFSNSLFTFNGAFYNNSTKFSYTRIRLGQRKVLVPIEFNCIMEAILTKNLNESGLFRKSANISDLERCFSLINDKETRQMYRLEIINRLLPFNIITLTVVYKRLFDNYEMPLIPHSYLKILLNVAKLENKYEQIVILKYVLYMIPKSNRNMVDSITQFFALMRYLVTNYNKKPTHNMDLHGFAVVIMPKIFLKPGTSVSLNDINDLIKITEFLFENRKILFSVGVERIKRNGQYMVDYYDSGIVAKVVHKGETDMDEVEEGDDYDDTTGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU93</accession>
    <name>L7JU93_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU93"/>
    <dbReference type="FunCoup" id="L7JU93">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2525"/>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_1"/>
    <dbReference type="InParanoid" id="L7JU93"/>
    <dbReference type="OMA" id="WYANCPG"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="328" mass="36537" checksum="C12BF896996065C6" modified="2013-03-06" version="1">MNKTITPIQAINIALDEEMEHNPKIFIIGEEVGVHGGAYGATLNLQKKYGEHRVVDSPISEIGFTGLAAGAAQAGLHPVVDYMTWNFALQSIDHIINTCAKSLYMSNGLLRTPIVFRGPNGFNYGVGAQHTQDFGCYYGAVPGLKVVAPYSARDHRGCLRRALRDKNPVIFLENEVLYKKHFERCKSFDDKEYIQEFKAVVEKEGQDITLIGISLTVGICLEAAQALEEDGISVEVINLISIRPIDYATLVESVQKTRRLIIVDNSWPCFSIASEISANIHEKMFSLLKMPVERINAEDVPTPYALNLEQLSLPSTENVVKRVRDIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUI4</accession>
    <name>L7JUI4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="1">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="1"/>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUI4"/>
    <dbReference type="STRING" id="72359.L7JUI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1873"/>
    <dbReference type="HOGENOM" id="CLU_022279_0_1_1"/>
    <dbReference type="InParanoid" id="L7JUI4"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="378"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="422"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="446"/>
            <end position="449"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="521" mass="57599" checksum="70E5BB03A89CA327" modified="2013-03-06" version="1">MKENDMKEELERCEAEEFTERMVAMYKENGEEKYLSLTDQVHLLIPHKYTNILPDKNVVDQMLAVTRLPQVYTVVGLPDIHLGYAFPIGSVVGAGIVVPEGVGSDINCGVRMVRTRTNCRNVDIAEVARQLFDVIPSGIGADTANATVSEIAEQLNKNVADTSNKEMVFTDLKVINEICNEGIDFLVKYGIVGDERDRIEKGGRFPGDSRMLSQKAKAKGLKQLGSLGAGNHFLELQRVVEVHDNDAGFEIDELVFMIHTGSRGLGFEVCESASQVATSMRSISKSEIGDESHEIRQVKQAMGLYENDETTVSSVNSSQLGSFENLSYFEIHESEDYILEMGCAANFAFCNRAIISKKVENVLKNWNIKCELVYDVGHNSLHKENIDGKELFVHRKGAARALPPNHPELRSNRENGQPIPIGGSMGTSSYLLYAQDTKKSLFSSPHGAGRRISRSKARKLITMEQLKQMMGNTVLMSKSEKGAIEEAPIVYKDIEDVVNAAVELGLVKKVVKLEPLAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUK5</accession>
    <name>L7JUK5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2042"/>
    <dbReference type="HOGENOM" id="CLU_3362242_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUK5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4212" checksum="4E4B72CAD309632D" modified="2013-03-06" version="1" fragment="single">VVGPSAQESTRWCERFIETLFKTYAVQFHLIKLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUT7</accession>
    <name>L7JUT7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dual-specificity tyrosine-phosphorylation regulated kinase</fullName>
            <ecNumber evidence="9">2.7.12.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="9"/>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUT7"/>
    <dbReference type="FunCoup" id="L7JUT7">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1851"/>
    <dbReference type="HOGENOM" id="CLU_000288_5_15_1"/>
    <dbReference type="InParanoid" id="L7JUT7"/>
    <dbReference type="OMA" id="QMEGITH"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="441" mass="51304" checksum="CA77A0F1869520FE" modified="2013-03-06" version="1">MYGDSNIFDNLTNIKLKKNDLICTGRNKFIVQDYLGCGTFADVYKIEDLYSNNQFAIKIFKSGTCYLKVGMNEAFLLKKLRNYRNHFVIFYEEFFYKQHFCIVEQLLSNNLYEFIKYTNHQGFDHDMTKNIAIQLLNALFILQMEGITHGDIKPENICLDKIDDKSFKIKIIDLGSSFTQPKKNSFYIQSRYYRAPETILGLNYGHGIDLWSLGCVIYEVFTGVPLFPGKSNKEQIMRYTKLLGIPPIAMLENGKNVQLYFYKKDDETAKSCSTWHNFYDKNEDTFGIVTNKENKTDLLGNTAGFGHPGKSNDYKMCYSDANDEKDYLTMPGFRKSITSRSKNKTDNANLMDFLLSILKMHPMERPIIEDLKEHPYLVITDLRHKRIQNLGKAQRNIVNPLPQEQNLRRKSEYGMRTLKVTNQPGRKFSVYENLSDSEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUU6</accession>
    <name>L7JUU6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1861"/>
    <dbReference type="HOGENOM" id="CLU_1284142_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUU6"/>
    <dbReference type="OMA" id="THQNHES"/>
    <dbReference type="OrthoDB" id="10483408at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="224" mass="25286" checksum="3B6A0ACF8FEAB028" modified="2013-03-06" version="1">MLINVLIQIVCAAEGRLDAYSTTISKKLVKVVENIETMHNSNDALEKLRKMDKNTIKNAQKLYNTFQTCRNEFASSSGDLKCYIRTVACALDLVNLTKQLVTVSEIKDVDLTVYDVLKTTFRDKKVLAEYCAGMGTDEEKTSKFKTTVSSVLDKLGETLCQLDMLCFRILNDMVVDVCLLRSILSRHTCKMCEIVPTHSENVERTVSQELSHHEGSLTHQNHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUW7</accession>
    <name>L7JUW7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase (Reverse transcriptase), Non LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUW7"/>
    <dbReference type="STRING" id="72359.L7JUW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2236"/>
    <dbReference type="HOGENOM" id="CLU_034416_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUW7"/>
    <dbReference type="OMA" id="SENEWNI"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="360" mass="40478" checksum="88609B6A3DE8F5FC" modified="2013-03-06" version="1" fragment="single">VTRICADRLSNISEREKILIHEQAGSRKLEECVAHATSLYEIARQRSLKGRAPYAAFLDFSKAYDRVPHEGLLAKLKSYGFHGKLLRLLTAMYRRPCASVLTGDTRSAPFIYNIGVRQGCPASPILFNLYINDLFDGFSGVAIQPGVRSIPGLLFADDAVVLAESAHELQSNLQRISDWCERWRISLNIEKCGLVVFGPGEARNMCYRGQSLPVVASYTYLGHPLMPDLDLNVVIQDRKEKAIRAYHGMRPFLTRNFVPAPIKMLLVKSVLLPIATYGCELYGMSTSRLAHLQRVIDHALKDILSCSSSYCRNPAYEELRIDCVAMRAAKLRTHAFLKWKTSRTTFGELMNQTFKCLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUY0</accession>
    <name>L7JUY0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor 1A (EIF-1A)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUY0"/>
    <dbReference type="FunCoup" id="L7JUY0">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1775"/>
    <dbReference type="HOGENOM" id="CLU_109098_1_1_1"/>
    <dbReference type="InParanoid" id="L7JUY0"/>
    <dbReference type="OMA" id="RRVMMHA"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="119" mass="13609" checksum="D7A94C0DA0D64ACC" modified="2013-03-06" version="1">MRKKGGRSRNINAQRTMVYAEPGISVYGQITRAFGSGRFEVICSDSSTRVCKVRGSMYKRVWIQANDIVLISNREEDDKGDIMHKYFPYEIKQLKDSKLIPDNFSGDKENAAAIEFDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV24</accession>
    <name>L7JV24_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1760"/>
    <dbReference type="HOGENOM" id="CLU_839879_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV24"/>
    <dbReference type="OMA" id="FMSIANC"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="331" mass="38829" checksum="B0247CD2B5AC386C" modified="2013-03-06" version="1">MGIDSYIWIYALILYIKQIGACSEPSTSTSIVIDGVKYEIACESERGSFFRSFFIDYIQIVIIFKQIEKILIKQEGRRDKLIAIFPDDLLKSGVYNDTIMNVENWRSIEQSYSSFMSIANCLRNNPENIMRFDPCDIRYWETNVETVSFTMLFFRYLLLFLMPDLSQIDMAIAKESIMKIDGQLNMPFFNHEKGKLVFENIAYMKRMDDMCKEVDEMVVKVKEWIEPAEDILLKKLTILGEKLFENEKLDLSSKHSQLKTFDLLFESRQLKFLDILIEILPIIEYIKSDPNTLAECRQMLNMRLVKKVYEDVTSVETRTNLKKKKAQGLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV50</accession>
    <name>L7JV50_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2420"/>
    <dbReference type="HOGENOM" id="CLU_2442431_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV50"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="90" mass="10115" checksum="7183605637BE62A8" modified="2013-03-06" version="1">MDFLINDTTYVVNCELTIRGVSISTSLKLSFNIKKIYFEHVCVAENSIVQIDSGFESITMVTCFGKYSIPNITYNDNSFVNLLGNQCSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV91</accession>
    <name>L7JV91_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1645"/>
    <dbReference type="HOGENOM" id="CLU_665956_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV91"/>
    <dbReference type="OMA" id="WFVIYLA"/>
    <dbReference type="OrthoDB" id="10477434at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="413" mass="48856" checksum="B8F11121D7B35B0B" modified="2013-03-06" version="1">MVDLWQPIERKYRNRKHLYIYVVIVLVYFMTAFVRLRSVEHNIALPTRLLIYSLVFPLIFFTIQLAILILIPHKSVLLFFYILPGLNVIYMLRFNVFLFLICGLVLFILILHLNNILSSPDYVFIGQLTQIGAKMIVMFYFTVVILMIPCYVQNIIFLVVEYYCSLSDNFSLWYVIIVLISSFQLLLNILLYNDVIGTFVSSLLYCNIMYHKISYWKKVVASAKNTFYCFGSLFKSEYLRVKSNIWDIRSDLESSALFLNEGTQNYSALVLNRCRYDWFVIYLAITGRSFESTCRELKNVITPNESAFLQINRITTKLFTLGLPVYFYTFLSFYYIFFKVNVFGNAEFKSARFRILLVFLVCCCTLYYAFYKYLAQAVFFLYANYKEDFECEYPSYYQMVTNGIPTGYRVQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVD9</accession>
    <name>L7JVD9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1594"/>
    <dbReference type="HOGENOM" id="CLU_311733_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVD9"/>
    <dbReference type="OMA" id="ISARACM"/>
    <dbReference type="OrthoDB" id="10495330at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="946" mass="108593" checksum="9888E690690DB2B6" modified="2013-03-06" version="1">MFSIAKKKTCIVIGYILIFYSPDKFSEKEYIIIKDLKETRLEKIFMFSDVTNSEMKASMIKKYDYDDEKDEFGLFSEFDQQAHCSSAGGRESADCTMREEDETNTNFETAQIRPNVIYKALELPITLTLYSKLQKLTPETSQVKLANNEIYHCLIYLLFIWEKPEIIAFIVCNHLQDDPTLYEWLLAGNTGTNMSQEEITKNKADIYRALMCLGTIVRSNIEFIVTGRNFGEESACSRFTTNQVLPRMYLLLSELRIGIFINYLSMKVRFLEVNDDLLAEKFEYYKNESQLEVQINFVQPSQAYSSMKNIDEMYRQMFLSLANSKFLYLENVVKINLNFGEIDFTPYFDVLTGLNSKIAVITYKHPNGICYNAIPSAISEISVSFLYNFSQNCACYCSDKVRELSISDAKIPCNLSLGTNTQVFKAYDIEICSEAVLVLDHRLKLVSIMNVNGDIEPCENGCYNTIYLLKSKGGNFYYESKEEVILRISGAEINNLLLTDDVTEIILDSITISEENQLRLNVGFKNLSIQDCCGKINFSGFMNLFELTFVETTVFVYEINKDTRRTEVLIERLALDSDTNMNLLSAYIRLVAVDTCGHILVINCKNHSSYLHLKSCVGNFVLVEPESLKRLNLEFDENGNFSLDYEGEFSMLTHLYLSYNTRYRELVERIVRSRQNLEVFVFYCPSLDNAEESQNRLPSVNEASSVTDENISGNPSGEDGTTRSDINVADRALHNEMNALLHHFLSNTSVQNKLRSLDITNFPIINVNYEMLEIFTNLDTLCVSFFFSNFHHILERLPATIMSLTVVGKAENHGKYQKTNIGASTCIKLRSNMVLRKLRINGCFIENLEMFLANLPMRLEVLSVNLSKVEYKNSTCCSPKVYIIKLVLNFFEECPPGLFDDEVDEHGKLRHILSFLSQFIHFKYTHSVICTRGTQRRTIDPNIFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVE3</accession>
    <name>L7JVE3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2064"/>
    <dbReference type="HOGENOM" id="CLU_3130050_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVE3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="6427" checksum="1E60FA1B378DDBCF" modified="2013-03-06" version="1" fragment="single">VSYRGERYVLRPKYDPDESFSDWKKLYSYYELIKKPRKRKAWRRRQKPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVN2</accession>
    <name>L7JVN2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Choline kinase</fullName>
            <ecNumber evidence="2">2.7.1.32</ecNumber>
            <ecNumber evidence="2">2.7.1.82</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.32" evidence="2"/>
    <dbReference type="EC" id="2.7.1.82" evidence="2"/>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVN2"/>
    <dbReference type="STRING" id="72359.L7JVN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1935"/>
    <dbReference type="HOGENOM" id="CLU_888755_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVN2"/>
    <dbReference type="OMA" id="WKEYANS"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="323" mass="38252" checksum="16EF2C5FD20A2635" modified="2013-03-06" version="1">MSQESYLTAVKVFLAKRGEKFIGILREKKAYSNLVYQILSNRNRYILKLYINRERSNEFEILKYVNVPKIYEMKSGYRIEEFLRHEVPDFKRDIKLIATALAQFHNTDVPGIESFEDMLIKLVLENQTLKHNESITNVYNKLKYLLEDKSMDGLIHMDLQVGNMLKIDNLVRLIDFEYSCTGSIILDIANFFCETMTNYQHDSILLAERGFNVSHKKRFLEEYLKHNRDIAMNVEEMYARVEEMQSLSHFFWFLWGRKRVFMNDTTSDCFDYVTYSLNRLSFLECAHFGHDISKLREEILSLGSTSKTKDKSSKRSTRTKNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVP5</accession>
    <name>L7JVP5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Endonuclease/exonuclease/phosphatase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVP5"/>
    <dbReference type="STRING" id="72359.L7JVP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2289"/>
    <dbReference type="HOGENOM" id="CLU_1185754_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVP5"/>
    <dbReference type="OrthoDB" id="2671967at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="234" mass="26098" checksum="FDE60C3510205171" modified="2013-03-06" version="1">MSRPAEDAASLHCQVQHPMTIKDRITRSKDGLTRIGVWKLEAFTTKTVKRLLGGQLDTELLVKRIRQSDGVRRHDVWLESAFYNAHARVVRNAVERVGGHMKVFENGRVRVPKPRVITTRGKPNSHLSAMTVNICGVMGKRADLCTVLDRKQPVIVALQETLLVREDYRLLLPGYATIESKMTAEDGSRGLALCIRKQSGLQLSEYKADPCFLAGTVEGLAEDNTTFSILMVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVQ8</accession>
    <name>L7JVQ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1556"/>
    <dbReference type="HOGENOM" id="CLU_2672861_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVQ8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="75" mass="8735" checksum="A2E225D7FBB8DC3D" modified="2013-03-06" version="1">MRSVESDMINESEMLASVKSSLNLFVTEKYSKRILSESKKCMNRLYEILGIREEVVRSLTNKGLYHFSRAVIVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVS0</accession>
    <name>L7JVS0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1567"/>
    <dbReference type="HOGENOM" id="CLU_499675_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVS0"/>
    <dbReference type="OMA" id="TIICVEM"/>
    <dbReference type="OrthoDB" id="10417643at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="597" mass="67563" checksum="AD546AA823F39D3F" modified="2013-03-06" version="1" fragment="single">VHQSYKTRFSIIHSLLHNQTNHSNIKKKKKMRLMNITDVFLVGLRLTLELFAYYNAKLMYSSSTSSMISPLLITYITHSVVSFLVIQDVFTMRKNYLRSIYRDTGLPPGTFLLFTFILSFIFNLSHIPKYFSLNKFSDLFIVSFSCLSVIATHWLCVVTKRKKMSVMSIVLTLIAGFGVLLLVKEECGTADRWLLALLLFVGSIFSGFYTVFMKIFMEIRPYRNDRARREERHASRSDRGCCIEHALKTGNFVKNKRTAAGCTNEHVHVFREMEKSPAAACDKNAIEIQRRLKATSSGNILIVDQRSSKDIILEQRIGKAENAGTSVTGPDTAKCMEGTGDGKGAKNGEECVCCVNKPTITRFEDEHVQAKRVSPAACAPFMNGDSTANFQFCLNDGNSANNTSDYEKLAAQENAWNGDGDNERQEFDFVEVHRGSKNEISDKQPFKRSDTPNRSSATSNYMQTFIQSFVYKINKKDVTEQQLSDLSFMRHYLGTTGILTLLFYWPMVIIPLDALQPTFGVHGTRLLIHVVISNILSISQNILYFVLVTCRSPHFVQLSGMILQPTIICVEMLMVMTCFTKRLVGFGCIFGSLFFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVY4</accession>
    <name>L7JVY4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993954">
        <property type="protein sequence ID" value="ELQ75475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1579"/>
    <dbReference type="HOGENOM" id="CLU_2147620_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVY4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="112" mass="12949" checksum="0ACF5A0D4ADF17B3" modified="2013-03-06" version="1">MNDNAFNITVSSNEKDAPKMLDGNDYTCWSPSLRAPHYIRINSMNYFGEIVLINQAGYNCRTIAVRDKTYLFDEDAMVQVINLDEHVNGVEIKIVDTWDPYGRVCIYNMFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVY9</accession>
    <name>L7JVY9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1913"/>
    <dbReference type="HOGENOM" id="CLU_1367097_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVY9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="200" mass="23437" checksum="F678E1F1AE720C44" modified="2013-03-06" version="1">MSIQADLMLIHQELAQFISHGIVDKGGNIAVTSKKNVKLYIQVPIETFNEESKLYIDHFAYDYQYVLDNVNFMQEIVLNDQHNDLLRTTDIDFRNYIYELRLSNSPPDESITSDRMVCININFMFQGEAFKNITFQKLILQLSNVHLNISSLLIRACKIILYCSDSTIEASDELLNILTEFYIWNSRITNTIELHYYFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW00</accession>
    <name>L7JW00_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar H+-ATPase V1 sector, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW00"/>
    <dbReference type="STRING" id="72359.L7JW00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1819"/>
    <dbReference type="HOGENOM" id="CLU_2365432_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW00"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="96" mass="11217" checksum="2E9DC27B8F481BC5" modified="2013-03-06" version="1" fragment="single">VKKRLMGVHLNQQLINQTMEVVRDEKDVVVYVLARDRNRVNVRGEIRELESDRLGGIIVMSKDGTVLVDNSYLTRLEKVRIQHMPTVSKELFRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW38</accession>
    <name>L7JW38_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993948">
        <property type="protein sequence ID" value="ELQ75535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1510"/>
    <dbReference type="HOGENOM" id="CLU_1856705_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW38"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15645" checksum="1FB2D26F4EE062A5" modified="2013-03-06" version="1" fragment="single">MRKIKKICNFSHDTWDTAVHLAIDAYNKSFHRAVGCSPFELLHKETPLFSVDAGLVSDKYSPRISGHVLEARRTSILKSYAKEFEGSVTAQNTFAEGDKVLRYNFSPLLNKLDPHWVSGYTVKRVKQGSEALTVEKNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWB6</accession>
    <name>L7JWB6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cis-prenyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWB6"/>
    <dbReference type="FunCoup" id="L7JWB6">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1286"/>
    <dbReference type="HOGENOM" id="CLU_1165579_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWB6"/>
    <dbReference type="OMA" id="DFRAPHF"/>
    <dbReference type="OrthoDB" id="2191730at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="244" mass="28943" checksum="BA174ED4AFC286CE" modified="2013-03-06" version="1">MVKNEQLNVSDSYLIKNIKNAFYLIVVVIIEYVVNNRVLIKILKIFPVPSTKVDYNVAFILDGNRRYARARNLSIKDGKKDGLLNLKRILTYIEHTNIKEVSVYAYSLQNFQQRDRIELESVFDLLRTERMEDFNYQLRFYGSLEFLKPKERSILKALESNTKFKGKRLNICILYSGLLEIKPYFDKPDILVRTGNQRRLSDFLLLHCANGCNLNFLERMWPEFEVWQFYLLLVKYSIENQITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWF3</accession>
    <name>L7JWF3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWF3"/>
    <dbReference type="FunCoup" id="L7JWF3">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1259"/>
    <dbReference type="HOGENOM" id="CLU_039781_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWF3"/>
    <dbReference type="OMA" id="VSWGKIA"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="316" mass="34968" checksum="F0DEF9D02CD0DFB4" modified="2013-03-06" version="1">MVKKVPLTPPQKMQKQIKPKKSVKEFAAQHKHTLTLAHKVSSIMPQHLTLSSLLSSFRSTGYQSTNLWRAISTLKRSKHGIVLGFTSNIVSCGLRDTIRYLIPYCKAVVTTTGAIEEDIIKTVHDFYVTDYHAHAGCELRANGYNRIGNLAVHNDSYVWFEQYLQDKLCSIEGTLSTAEFVDMIAPDDAQSFVACAKRLKVPVFVCALGDGSIGDIYTFGRNMQFAIDAAKDFRQFLDVAKGCTGLVVGDGAVRHRMAYAQLSSTVHITTRTAYDGSDMERMLDSSVRVVGEASVLMPLLVYGTYECADFNEGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWJ6</accession>
    <name>L7JWJ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein involved in vacuole import and degradation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1255"/>
    <dbReference type="HOGENOM" id="CLU_007002_1_1_1"/>
    <dbReference type="InParanoid" id="L7JWJ6"/>
    <dbReference type="OMA" id="AYKMREY"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="1">
        <location>
            <begin position="117"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="395" mass="44929" checksum="F9BACA62B34A8962" modified="2013-03-06" version="1" fragment="single">VPTCSSTWTRTRRALCGRALILRRTWWCFTREIEFLEFMSLFLDALKKESGFVGGDYGVVHGESAFKDIEKDAFDDADAYSFANECAAEQHTESESEEHEARPDGGDDAYNSLLYTDKDTAFVARGNTVGVFNTADRLTFNCSIKNVEGKKRKFLKKDNQLLFLDENRKDVKFLDLEKGRVVERIGLTRDVNDVMLRDSELLGMNDNSVFVVDSRTKGIGRDNTYKTKTYFTKGSTNGTFSAIGSVKGDLRVYKDVFKRARILVSGLGDEVLGIDIGNEYVILTFKNYLILFKIEERKNSRKVVRLQLRPEHVAFLKHSVSFTAAKFNTSNTDIITSTGQYVVTWRVCDVLNGNLYAYKMREYGSEVVDDSFVGEDRVLVTLKDDLKMLNKKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWK3</accession>
    <name>L7JWK3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1337"/>
    <dbReference type="HOGENOM" id="CLU_2456347_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWK3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979202" evidence="3">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="9240" checksum="0728F3B6F8B2B77C" modified="2013-03-06" version="1">MHKLLKNLFVLLAFAAFVFAANSKTEKETTTEDNDGASGGSDGETTDSKKDKTEEKSSSSSKDKSKNGAGSMLALGGAIITGICMCAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWM4</accession>
    <name>L7JWM4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993919">
        <property type="protein sequence ID" value="ELQ75824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1217"/>
    <dbReference type="HOGENOM" id="CLU_2529068_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWM4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="84" mass="9291" checksum="7C9B04769B1C00CC" modified="2013-03-06" version="1">MFAAVVVVEHVVIEQVEVVVAVEVVVAVAAAEPAERIVVQDGMADTMLLWRENIVLFHSDQHKYFGKNLTTAVLDMADRTKQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWN4</accession>
    <name>L7JWN4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Meiotic recombination protein Dmc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1138</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWN4"/>
    <dbReference type="FunCoup" id="L7JWN4">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1138"/>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWN4"/>
    <dbReference type="OMA" id="ANPMKPV"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="98"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="272"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="37439" checksum="08C9E9590DDFE7CA" modified="2013-03-06" version="1" fragment="single">VQVLSCMIETDQTQLNESTDDVLPIEELQNHGITMPDILKLKQYGICTIKGLSMVTKRHLSRIKGLSEPKIDRLKEVASKAVRMDFTTAIEYAAKREQVVRITTGSSDLDALLNGGVQTMSVTEIFGEFRTGKTQICLTLCITAQLQENSKVAYIDTEGTFRPERLREIAARFDIDQEQALQNVICARAYNSDHQVDLLNTLSARFSDDPTYRLLIIDSVIALFRTDFIGRGELGERQQKLNIFLSRLQRMAEEYNIAVLITNQMMSDPSATLTFVADPKKPIGGHVLAHASTTRIYLRKGKGETRIAKIYDSPELPENEAMYAITSGGIDNASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWX9</accession>
    <name>L7JWX9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_1047</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JH993892">
        <property type="protein sequence ID" value="ELQ75983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWX9"/>
    <dbReference type="STRING" id="72359.L7JWX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1047"/>
    <dbReference type="HOGENOM" id="CLU_1066243_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWX9"/>
    <dbReference type="OMA" id="DMDSHIQ"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ75983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="252" mass="28910" checksum="8F2E0CEC1E2E6C36" modified="2013-03-06" version="1">MPYHTIYYCHACGSRTVPHNELCAFCDSEFIEIYDSVEYYRSVHFGIGEILRSIAIGQVDVNELDWLISDISDRIRRLTRDLLNIRSSRGRRARRNTHAWRALEGAVDAAQRYNERAHASDHGMHDDARMRASIAHAYGHPANDISDYVYGSTLSTADDINNYAFDHELEHIIDEIFMSTKVSTSPVSNKYIKALQVSHARQKGKCMICLSTYRKGECGIELSCAHFFHKSCGVKWMKMQNTCPICRHEIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX09</accession>
    <name>L7JX09_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1212"/>
    <dbReference type="HOGENOM" id="CLU_1161899_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX09"/>
    <dbReference type="OMA" id="WFLRGMG"/>
    <dbReference type="OrthoDB" id="10424852at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="199" mass="22370" checksum="B8EB4586BA6D0B55" modified="2013-03-06" version="1">MFDIVGADFDLDTMPSFITRYAVNEEYNGNRKGVRRGNGGNNNTIISNGYKNMVTNSSTDIAVKGPLPYTMVSVNANKTLITDLLRTRSYDLINTLIRTKEDVSIAIDTQTHIITLIGNVTIENGQLQKLREKRIHVNIPVFTNAHMLITLRKYTDILVLSTYARNAHELRTENEMKWFLRGMGMVRGCVNVCVAIGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX22</accession>
    <name>L7JX22_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1021</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX22"/>
    <dbReference type="FunCoup" id="L7JX22">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1021"/>
    <dbReference type="HOGENOM" id="CLU_027721_3_0_1"/>
    <dbReference type="InParanoid" id="L7JX22"/>
    <dbReference type="OMA" id="SDGIYFK"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="134"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="332" mass="40221" checksum="26C387ABF45D3421" modified="2013-03-06" version="1" fragment="single">YTENQHIYQFITQLHYRRYLNIYIHSNMFKKISRQFIASTLINSFVILLFIFNYYVLMFVHTRKIYKYNKNIIFYCIGNFLSLYILILYVQVYYQIIPSKCAYKIRQMGEHTETNLNSIFNPYFTQNILKERTETMKTCEKCGMYRPPRAYHCYICDTCFMKMYHHSYIFNTCIGHTNYKYYYLLLMSNFIYSLFQLILLLYFAINARQTPQRMTFYALAIVSNSIFVVTSLIYLIINTKLLLYNETTTERSAINNFLEGRDDYKDVFQEGVLCFEDEVHVKDRKILNPYFLGYKENIKEVFGDNYYEWIMPYFTGRSDGIYFKKSVINKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX59</accession>
    <name>L7JX59_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cdc37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX59"/>
    <dbReference type="STRING" id="72359.L7JX59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1708"/>
    <dbReference type="HOGENOM" id="CLU_113437_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX59"/>
    <dbReference type="OMA" id="CRKYYED"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="218" mass="25827" checksum="C459F9763D62A1AC" modified="2013-03-06" version="1">MSLTLVMNHPINEMELSSDSTEYEHPNIEKSTLRRLVREKRKHDKEEWAKELDNIKKILSERYDPELENRKKFLEQKLKPKFVETSTNMINNTVEERNEDDKFADYLLFLGGDPTIDNFIEFVEDTKNINLERFDEFLLMNLSENIKEGLDEAGMVISTLSLYFKYLKQGGMPLLRKLSDSLKDESKKHIFDEECRKYYEDSKDALLNLKNTRKQTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXA2</accession>
    <name>L7JXA2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXA2"/>
    <dbReference type="FunCoup" id="L7JXA2">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1107"/>
    <dbReference type="HOGENOM" id="CLU_150908_2_1_1"/>
    <dbReference type="InParanoid" id="L7JXA2"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="93" mass="10685" checksum="40EB22BFE70197CA" modified="2013-03-06" version="1">MTKGTSSFGKKNKHNHTFCIRCGKTSFNKQKRTCSACAYPAPKWKRPASYKAKQRKNVDKRCRHMKRSLKSARSGFKGDPVMKAILSKYEVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXM9</accession>
    <name>L7JXM9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0819"/>
    <dbReference type="HOGENOM" id="CLU_748389_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXM9"/>
    <dbReference type="OMA" id="RVCHHIQ"/>
    <dbReference type="OrthoDB" id="10348043at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="370" mass="44766" checksum="20B9A9DF1ED160CB" modified="2013-03-06" version="1">MFLNTKYIFTGITYLKMVLLQTQISYHNIISNFCHKLRGLSDKQGNRLGGMVQTCRKTTNPNTFLLHIDYFERFFLNNTHDEMIMMYLMDEIEELLWFIFSFHDSRGKMFTNLVSYYTSKYKNCNKRNIYEFINLLYKCLNLKVTIFSYPTNQVETNEYIYRFYHSRNVLIEENLAQYKFDFLGHTRRMAKTIEMLDVMNGIRKDVFNMFGWNDNAQSRLFIEYIFENDYYVVRNNYFLEILIAFMYQVKGNTILKDLQQKIYAFYEPGRVCHHIQGFYRHVFTMIYEKFLHYSTRQKRRISNDGLRLTKCQSLNLDHIDDHMPFKLLSSPKRKRTDNFARVTAFSPLRKRLNLVTKRNSYESAKKLNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXQ9</accession>
    <name>L7JXQ9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">THOM_3303</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXQ9"/>
    <dbReference type="STRING" id="72359.L7JXQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3303"/>
    <dbReference type="HOGENOM" id="CLU_428727_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXQ9"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="153"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="397"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="282"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="283"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ELQ76105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="639" mass="70660" checksum="EACABAC21A62F740" modified="2013-03-06" version="1" fragment="single">SPLTTHSTIPNQTIQQSKHIIHQINESKKNGKGEGYKTQMFIHAPRMHNHTQLIIHSDHLSHTSLHLYEALGLDVKIYQLKSTRKVIITGNERVQLRAMTDSIHVILKTTNALHVLSEQYDIDRLMDRHTLTLRDTLGNEIHVQFDPTITPRRIAVLTSGGDAPGMNMCVHAIVRTAIKCNSVVYGVYDGYAGLMSGALRRLNFNDVVRHASMGGTFLRSSRCPEFMERAGRKKAALCLLRKGIDCLVVLGGDGSVKGAYTLQREFDEFVEEFIAEGLIECLDGGDEGNEEDGGNEEDGGNEEDGGNEEDGGDEEDGGDEEDEEDGGNEGNEGKNRKDKGKAKNTKNVKNTKKNNTKAKNTKAKDANNTKKNNPKENNPRKNNPKAKDASPAHTPILTKRYSLKVVHIPCSIDNDIPSTDTMIGSDTALHRVIECFDSLCFTMDSHRRAFVIEVMGRHCGFIALMSGFAVNADFVLLPESTNDHWQHKLIACIRRVRSYGKNGIAVILAEGATDSMGRCINAEEVKQLIVRTTGIDSRVLRLGHIQRGGAPSARDRILAVLSGMEAVSNLLYGTDEAVSVCSRNNMLRRVGMEELIGECERVKRMDDKGNVEGTRGSFFRMAHCLLEELRAYHSDKDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXV2</accession>
    <name>L7JXV2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription initiation factor TFIID, subunit BDF1</fullName>
            <ecNumber evidence="5">2.3.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.1.48" evidence="5"/>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXV2"/>
    <dbReference type="STRING" id="72359.L7JXV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1445"/>
    <dbReference type="HOGENOM" id="CLU_001499_5_1_1"/>
    <dbReference type="InParanoid" id="L7JXV2"/>
    <dbReference type="OMA" id="KINWPFL"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="281" mass="32752" checksum="7C4CB985EEBEE038" modified="2013-03-06" version="1">MDLRTVSQKMKEYSSQTEFVNDVKLIFSNCYFYNGEDSPISKMAHELETYFEGLLSKNLKNNVDLDVCTNILNELVKTKHKKINWPFLEPVDTKLVPNYLSVIENPIDLSTIKRKLPFYENRIDFFADLLLMVNNCYKFNAKGTEIYTCGEEMEKLIDKNCSFLNEKDLLSSISQLKQQMAALSNTMSLYEDVLFHVRRREGKRKIFSLDERIRIADIVSKLDEERCVKIALIIKKNDQNFSIAGKEEVEVDFKILPDFIVEEIDTFLKKENVNAEQSSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXV9</accession>
    <name>L7JXV9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0759"/>
    <dbReference type="HOGENOM" id="CLU_2924354_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXV9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="7461" checksum="F0A88407672CE300" modified="2013-03-06" version="1">MINFKFEALRSMRNVKNVKRTKNVNYIDEHLDLILCNKLENGKRRLKRTKELELIHKLHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY11</accession>
    <name>L7JY11_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyridine nucleotide-disulfide oxidoreductase</fullName>
            <ecNumber evidence="14">1.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_0665</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="14"/>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY11"/>
    <dbReference type="FunCoup" id="L7JY11">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0665"/>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="InParanoid" id="L7JY11"/>
    <dbReference type="OMA" id="GTCINWG"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF1">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="317"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="459"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="9">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ76353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="578" mass="64744" checksum="3A7E434CD2CE1C84" modified="2013-03-06" version="1">MYDLIVIGGGSGGMAAAREAAKFNKRVLLVEKGELGGTCVNLGCVPKKITYNMTSIVEQMQLASSYGMQARYELNYELFKRCRDDVIRRLNAIYEKLLGNSNVEIIRGYARVISAGEVEVNGQVYKGTYILLASGSKPKALKIKGAEFVRYSDDFFYLTSIPKKTVIIGSGYISLEIAFMLALLGSDVSIVLRGKHFLSHFDTLFDAVVKEQLKKYRIETYYEENVLEVREESNDETNEGMMNGEDMVGNEGMMSNNETKEGMMSEEESENNEKKNRSNCKNSKSANEQISAEQKENDVPLDTSYGSKIKHMKVIDVSKEEIGRKVRFDIRGQKIDIEHKEDVYEIHKDELRVELEGQRTSKGVYEVVLKNTTIKNVNFVMCAIGRDCDLSYVQLPVHTYNNYAVVDHKFMTSVPNVYAVGDLVGPDHMLTPFAIFCSRKLVRFLFNDEPMPADVYEFVPSVIFTHPPCASVGLSEAAASAKYDSVEVYETRFNNLLYALSEHKTASVFKAIVHRGQVVGLHLFGNGVDEMVQGFALSMKNGLSLSDLNNCVCVHPTAAEEVVTLCRVTPRAADKRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY57</accession>
    <name>L7JY57_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0682"/>
    <dbReference type="HOGENOM" id="CLU_1157084_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY57"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979128" evidence="1">
        <location>
            <begin position="29"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="240" mass="27893" checksum="42246A3DFD150DB9" modified="2013-03-06" version="1">MSFVKLYKLLNLLYVFILLPSFLAVSDSEHEPPRKKRKYTSVWEDNPSSLGDMSMDVITKTLYKKYEAKIPKELETSFKSLESSVYGFINELEEENDARPMEIMGYISLADMLMKKLSLENVSHLNIVLVDYIIKDAGYIFKEYEKNVYEWESDNLNGQEHADTMAKDFDVAMTALKNFLYEIVPVIESDLSELRERLPTQIFNSIESRIIKFLNKTLRGLLGLKQKELSDRNDGKKSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYA2</accession>
    <name>L7JYA2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0735"/>
    <dbReference type="HOGENOM" id="CLU_2984813_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYA2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="6555" checksum="3D628A46BBDF98B0" modified="2013-03-06" version="1" fragment="single">VVVVLVGAEQRRIGRLVDCEGWCFYLYEVGDVVGQEMGTRTFFLFGVFCEGVDQFEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYE2</accession>
    <name>L7JYE2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mismatch repair ATPase MSH6 (MutS family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYE2"/>
    <dbReference type="FunCoup" id="L7JYE2">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0558"/>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="InParanoid" id="L7JYE2"/>
    <dbReference type="OMA" id="YWTPNIK"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="500"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="889" mass="102752" checksum="212DDA21DF76928B" modified="2013-03-06" version="1">MEKKQKSLLDFLSSPVKRTRSSIDDSPSSSQKVLHDVSTSQNNESLLSSEIDSLARNTDSTVVTPRRKKNMAEEKRYGFLADIRDSKGRRINDEGYDKSTLFISEQDMNMLTPFEKQFWSIKKNYFDTIVCFKKGKFYELYENDAEIGAKLFDMKIADRVNMRMAGFPVSCFDMWAGRFLEKGYKVARIDQKENMIGKRIREKEEKENRVANTKGREIIERELKEVITAGTVYNYNHIKTAHSVYLAVIKYCEDVSVSILLYDACINEILVKTFYEKLEENVRTVLAQYNIKEIISERKIEGRRVEHPIKGGSAVDFLQKFEINDEYVCFLYLDNYMQFLRRAEFKENVVIKRMADRRDYMVIDSISLANLNIIDEKTSLFNAINHCSTPYGQRLLRQWLLYPLADVTRIEERQEVTSEIEKLEIGAIKEELAAIGDLDRLTGKLNNRNYTVRDLFNLQANLLLACAFLDKFLARTNNSPILTAKFRSYGDVVCELKKNMKEFSDKYTVSENEVKASEKQNDEYTVYTKELSNIECRLKEYLEKQKSRLNCKLLSYKDLGKEIFQIEVPSTISVPTSYFLVSSTKTAKRYYTQDLKDLVNEHNECSERIFQAKGLILIRATQKFLESYSLFYKISDMLSEIDCFLSFATFSQVNTNTAYTKFTGNLAFENLRNPIFPNYLGNDFEFKDSKTLLLTGPNMAGKSTFLRTICLNVILSQMGMKVTADRMDSRVFDRIFTRLGASDNLLRGESTFMVEMKETGVILNECTPDSLIIIDELGRGTSTKDGESIARAVIEYLNRRNIYSLFSTHYHRIVDKVQNVRKGFMDAIVDDDDIIFLFKLREGVCYDSQGIPVARLAGVPKFITDRAIEVRTKILDGKAENGEEETNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYH7</accession>
    <name>L7JYH7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calponin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYH7"/>
    <dbReference type="FunCoup" id="L7JYH7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0546"/>
    <dbReference type="HOGENOM" id="CLU_055232_2_1_1"/>
    <dbReference type="InParanoid" id="L7JYH7"/>
    <dbReference type="OMA" id="WIKTITG"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001997">
        <property type="entry name" value="Calponin/LIMCH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00889">
        <property type="entry name" value="CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="176" mass="20064" checksum="BCDD194C7F135196" modified="2013-03-06" version="1">MSQQNTELKEWIEHITLETIGDNLEESLKDGIILCKLMNKLQPGSCNYSEKKSAFLQRENIFAFIRAAKKIGVEEYEIFDINDLYEGSNFNQVRICLYALCRCLRKTGEFKGPLIGPKMAEKQKIEFTPAQLNKSRTAASPYVSNKATIPKGTFSYGARRQICPQNKENANERNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYI8</accession>
    <name>L7JYI8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nucleic-acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYI8"/>
    <dbReference type="FunCoup" id="L7JYI8">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0688"/>
    <dbReference type="HOGENOM" id="CLU_081098_1_0_1"/>
    <dbReference type="InParanoid" id="L7JYI8"/>
    <dbReference type="OMA" id="PECVFAE"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="176" mass="20587" checksum="6D9F11121C0B831B" modified="2013-03-06" version="1">MKIKRKFCRVPKVLNISEKSKHTDKETNVIENEEPKFDEYFKINHNLAPPYNIIMDTNFILHSVRKKMDIETELMRVLFSNVIIYVPECVFAEIEKMGLKHRVALMAARKLKHQVLICDHKGTYADDCIINRITPSRCYIVATCDADLKRRIRRIPGVPILYINARKYAIESLPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYL2</accession>
    <name>L7JYL2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Rho GTPase-activating protein domain, Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0892"/>
    <dbReference type="HOGENOM" id="CLU_847823_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYL2"/>
    <dbReference type="OMA" id="AMHCIRT"/>
    <dbReference type="OrthoDB" id="2196166at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="106"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="328" mass="39021" checksum="264002E9A2EAFA2C" modified="2013-03-06" version="1">MDVADHKKNVSRSTGENDGKILETDKKKDEEEKKRTHERYNRCTKFDLNRCSRSSCSCSTSEYIKYIDLSNEEQYWLAMHCIRTLLRMKTKKKNTLLMIIDRIEKIFLDEDLNFIPQETVDTRIFDLLDHFEAYAPSSIGFLRLPGKKDVYHRLLDLMNEPAEIDFSKYEMRDNCSFFKLYIREKLKGIIYPCLASSLYYFYDRNRKDELCKIKKYLPFVFIGHRRKLLLRILHLYRKIGNNEEITKMSIRSLVVCSTPSFFPASDANVALPAKQVKIFESLFDMQFKYVSRDLLDESEKLRIISTTTDEDEFDYGYDSVNEDEFMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYM7</accession>
    <name>L7JYM7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0607"/>
    <dbReference type="HOGENOM" id="CLU_2028338_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYM7"/>
    <dbReference type="OMA" id="VRYVIFK"/>
    <dbReference type="OrthoDB" id="10459606at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="122" mass="14644" checksum="97EEEAD358795573" modified="2013-03-06" version="1">MVTKKVRYVIFKIESGNNTLLKMSEESLLNIFRDQMYEMYGSFGMMHFQNVYITLFLLYNQIIVLKVPRVVKNEICYAMQHCKNIAGRNVKFNPVMAKSSIKRVKKYLKENFEKEEKMKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYR0</accession>
    <name>L7JYR0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dopey, predicted leucine zipper transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993907">
        <property type="protein sequence ID" value="ELQ75887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1151"/>
    <dbReference type="HOGENOM" id="CLU_036530_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYR0"/>
    <dbReference type="OMA" id="CCPELRI"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="551" mass="62474" checksum="A219BE2E8CEAFB85" modified="2013-03-06" version="1">MTKKFLYKGRLSALPMFDRNSQNNQRIRKRLEAFKNAKEWSDFISLLAAVDNALLDVKSLPHDLEALLFRRLNQSLNPALPAGVHNKALETYKLIITNIKLSERLLLGLFSYGVYSKLSVRNTFFEVMAKLKDCRINQKSYVLGLLPFVEEENAEHFERACNMIADIDSADALWANFLCCPELRIAVVNYFKGRHVSISTFAIRAICRALYDGDSFTVRGTLDMLNANVTLTDLIKFYNPEVNEFVELSAEKAMPSSKETSTVATYTNTTAVTTANIPQAPRRIKIEPAFLKDEIVQLGVHVIKLFLKKEVTLNKKVNAWLQNETMLTKKALRTIMSQDLNLFYKLFQNLIVQEELSDKDIAELFVEAAYCTRGECQGFDIVLTLLESTFLWKILYAEFRRVIGNARGRGFSEAEGKIGEDTVGDRNGKDGAEGKIRDRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLVMRLIGRMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYU7</accession>
    <name>L7JYU7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYU7"/>
    <dbReference type="FunCoup" id="L7JYU7">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0523"/>
    <dbReference type="HOGENOM" id="CLU_010412_5_4_1"/>
    <dbReference type="InParanoid" id="L7JYU7"/>
    <dbReference type="OMA" id="FKNGTMR"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6977" checksum="7F8E65B9799FC49B" modified="2013-03-06" version="1">MAKNIPLNRAGKVRNQTAKVPKKEKERAKTGRARRREMYSRRVEQGLFKNGTMRFNPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYY0</accession>
    <name>L7JYY0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYY0"/>
    <dbReference type="FunCoup" id="L7JYY0">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0797"/>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_1"/>
    <dbReference type="InParanoid" id="L7JYY0"/>
    <dbReference type="OMA" id="INQWPGV"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="200" mass="22963" checksum="65AC57662DA35400" modified="2013-03-06" version="1">MENIFDKYITDQKTIGIGTGNTIKTFISNIKTHNEKYFVPSSLQSFFLLKANNFRTQELQATETVDIYFDSADYFDNDNNLIKGRGGALLNEKLLMSMSKHNVILVDDKKFKSDFDDLFIPLEIIRSSLAHVKDVLRKHDIDFCVREYIGKIGPVITEHGNLIVDVKYDLKFLKSCKNIVGVVEHGLFLNDDFCVEIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ25</accession>
    <name>L7JZ25_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inositol-1,4,5-triphosphate 5-phosphatase (Synaptojanin), INP51/INP52/INP53 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ25"/>
    <dbReference type="STRING" id="72359.L7JZ25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0378"/>
    <dbReference type="HOGENOM" id="CLU_369270_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ25"/>
    <dbReference type="OMA" id="NIECANI"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="1">
        <location>
            <begin position="46"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="750" mass="87503" checksum="1E6243551FAE5FAF" modified="2013-03-06" version="1">MYDELRFFPLEGKLRFFLNSISIFVGDVDVGDDTQSIKMSNIDGILGKIMVNDNMYLLYVKESFLALDNLGYKIHRIKNIECANITSIEEFCKRKILRTKDKKNFRLVKDEFLNAMSHQSKDMENLVKFLNESPLYYTRDEIEDEKFLWNKVLRSNMNDAQNQTGIVYLYNGYFNVKACANFDYVLLSFISSNRVGPRYFSRGVDVEGNVSNFVKSKYLVVKNGSVIIDVIIYRGSVPVYWEQTGSLRELQCNEKDSFRACFKHFYNNFRDGEPVVEKQQDDERVSEFSGVMENNLQNRGAFTQPICHFNNILVINLLSNKKSEQKLSMIYKELLKNLNIQYLDFNLNKYHLNYRKLKHLFITELRIKINSIQERMRSCNNSYSKIIFRVNCLDCLDRTNLASYLICDYYHTQMEIPKNHLKTLFQENGNAISLFNAGSNALKNELAVKEKRSIKGLFDDFYIFTKRVISDKFNDKQKMEMIDTFLGRVKSGEPDSELVEQRSTESDSVFRNYMVSERAIEDSTMATKSPDSNANILSLNNFQADNRDESSFNEETALIITVKIASRHDFDNLDLQLSKTVRLIILCVNKVVSSLKSVFSEEDMTFRIKNFVLVSKKSYFNNHILIFSNMDAIKDISDIEYVERKRNLQFTKKNCLLAMKCTYKNTHLILFNVIMDKLYNLEFFEQNYNPRTDVLFLTGFFLNSKVLEIFKILNLSDIASSSCIKTGFKGNVTIKRHTENENANFVEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ35</accession>
    <name>L7JZ35_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0305"/>
    <dbReference type="HOGENOM" id="CLU_2656201_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ35"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978913" evidence="1">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8727" checksum="93E9EDC9BCC30661" modified="2013-03-06" version="1">MRAKLELIVLFVAYVLSNASYRGQNNDVCSPFDIGCRDYGLADYYPRYHFNGRYMGDERMRIPFSIALNAPILGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ88</accession>
    <name>L7JZ88_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ88"/>
    <dbReference type="STRING" id="72359.L7JZ88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0673"/>
    <dbReference type="HOGENOM" id="CLU_582135_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ88"/>
    <dbReference type="OMA" id="HENWRAT"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="2">
        <location>
            <begin position="87"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="470" mass="53339" checksum="33EB07A7A3404388" modified="2013-03-06" version="1" fragment="single">VSDESVDSEAYHACLKNAVFRSSFNLEMPYKTRAGIVSFKHQRSASILCQSLISSKMFSCIAQPAPAPNDIKYDNINKSPLLANIQRLLCSFLFVLFTLMFFSAVGVIASFCNLNYIESKFTRLADLLREHENWRATLNGVLSPLAYNILMTIGPIFIRLIITLESNYSGTADQLSLMNRYSVFLFLNGFLSFVTTYSVHQLSGFDELKKVLEGLQSGLLKTSVFFMNALIQKALVGQVLILLQVGPLISKSIAYVFGSKTLRSRKQLAMSIPLDFGTMYPNMLLIFAICLVYSIITPIILVVGFVFYVSCFAVFKNEFIYCVKNDTETGGVHFNFAATYIIYILIFFQASTAVQYLTTRNTYLSLCLFVLAVLTFFLKSAFLKSFQRACTFYPLSLQEEHYIDAFTRTLLLSRVRFIKKWTQHTGDEMVELRMLGYVDAECAMAYERPTDKEGVYLDTEVFLELEKIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ89</accession>
    <name>L7JZ89_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993816">
        <property type="protein sequence ID" value="ELQ76763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0242"/>
    <dbReference type="HOGENOM" id="CLU_1442102_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ89"/>
    <dbReference type="OMA" id="AWVFHNA"/>
    <dbReference type="OrthoDB" id="2195427at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="194" mass="22317" checksum="5F9B51A7379ECF9F" modified="2013-03-06" version="1">MLIYVLLVMSEHYEIHDDDVVSRNEMKRKDLSVKQMEEEDNAGGGNDGNEDGGIEDRDRGNGSRDGNGSRDGSNNTNPTTNTNPTTTTDPTEHTATFSSPAHESNRKAFRSLQSIKKQKKIKRHERNSRIKMTDLNYFKDEIKRNHNSHVHRVGNFANRAYYTYFSYHPSIRQSAWVFHNAHHGVHDGWRDDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZB3</accession>
    <name>L7JZB3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTPase Rab11/YPT3, small G protein superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZB3"/>
    <dbReference type="FunCoup" id="L7JZB3">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0232"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_0_1"/>
    <dbReference type="InParanoid" id="L7JZB3"/>
    <dbReference type="OMA" id="KRACCIN"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="207" mass="23424" checksum="8A49CFF66765EB79" modified="2013-03-06" version="1">MENYDYLFKIVLIGDSGVGKTNLLSQLTRKEFSAETKATIGVEFATKTFKIDSLVIKAQIWDTAGQERYRAITSAYYRGTLGALVVYDITRKSTLSNATKHWLTQLKEYSGEEIEIMLVGNKTDLEDERTVTVACGNDAAKSNNLNFLETSALDGSNVEKAFEELIKAVYRKRKALDPEFKEMLSRTEPVRNKKIIQIKKKKKKSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZB4</accession>
    <name>L7JZB4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0621"/>
    <dbReference type="HOGENOM" id="CLU_3207932_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZB4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="45" mass="5153" checksum="ADFBC0518E87D605" modified="2013-03-06" version="1">MKVKTHQSGELVKIPTDFNFDGMIYPRIKGVIVFSDYGMGRIIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZB9</accession>
    <name>L7JZB9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0626"/>
    <dbReference type="HOGENOM" id="CLU_3371051_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZB9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="4170" checksum="493F17F9526725AF" modified="2013-03-06" version="1" fragment="single">VNEEVNEEVNEELNEELNEEVNEELNDRILLEKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZC2</accession>
    <name>L7JZC2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="JH993874">
        <property type="protein sequence ID" value="ELQ76107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZC2"/>
    <dbReference type="FunCoup" id="L7JZC2">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0920"/>
    <dbReference type="HOGENOM" id="CLU_001493_1_0_1"/>
    <dbReference type="InParanoid" id="L7JZC2"/>
    <dbReference type="OMA" id="WFIRVER"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="95"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="423"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="753" mass="88340" checksum="ACDFA88E1783BBB8" modified="2013-03-06" version="1" fragment="single">VRKWLKRVNGSVFVGLRYEPPFEYFKKDFPTFFKVLKNEGVTDDSGTGIVHMAPAFGEEDYNVFLKEGLLRENDEVPCVIDDKGKFTSTDYKDLYFKDADKPIMKALGDRLLWRGTIRHRYPYCWRSDTPLIYKMVPNWFIHISDLREQLYKLNEKIHWVPPSVKNKFGNWLKCARDWSISRNRFWGTPIPIWTSSDFKVTLCISSIRELERLGFRMKDGQKIPVKIQDMHREFIDDILIEKNGVILRRIDEVFDCWFESGSMPLAQDHWPFSAFTADGIEKKLDQLELNVREPDAADFIGEGLDQTRGWFYTLHVISTLLFKRPAFKNIIVNGIVLAEDGKKMSKRLKNYPDPMEIANSYGMDSLRIYLISSPVVVAENLKFTERGVKEVFKNLMINWYNSLNFYVECSTKKRVNEKETILDEWIVNELCILAQRIKKNMERYELANILSDVLVFIDDLSNWYIRMNRMRIRNGEYGVLKTVLTKFSVLMAPFAPFFSEYSYQVLQGNSSLLNKDFKSVHYEAFPVFRPVHENNFDKTKRVIESIRVLRENQKISLKTPLSEVTIVGVDDFDHELIRTECNVLHVKTDSEDSYEFSTRLKPNFAEIKKRNNEKEIPQKIAVINKLEGINDIIRHNIVSDEIIIEKNIILQEKNRVAKNFGDFTVILNVQLNDELIEMKEGREFNAFLQKLRKRIGLKIDDTVKIYLDSADLRNIITKNYKIDFVDDDDTCLVLGEGLYEYEGQDVLVKIFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZD1</accession>
    <name>L7JZD1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0223"/>
    <dbReference type="HOGENOM" id="CLU_2677956_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZD1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979275" description="Transposable element encoded protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8188" checksum="E8DFCB4065E87BF6" modified="2013-03-06" version="1" fragment="single">VLRLLWCLGSCCALMRVLSVSTNEHGVLSCLDGPYFKLRNVEGNAEENDEDVEDVEGNGEDVEDVVEGEENGGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZL3</accession>
    <name>L7JZL3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multifunctional chaperone (14-3-3 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZL3"/>
    <dbReference type="FunCoup" id="L7JZL3">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0519"/>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZL3"/>
    <dbReference type="OMA" id="SKGTDKH"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="8"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="255" mass="30038" checksum="60859FBA35F476CD" modified="2013-03-06" version="1">MREDLNLDQLILRASLSERAERYEDMIKDMKRVIQLHWENKIEITPKVRNYFSMAFKNLTGTRRAAWRTLCIEKDKYKDTNLENYNVIVDYLVEVENELNTICDDVIGHIDKHILKENEIALDVESQVFFLKMKGDYFRYKAEVAAGQDFLAFKTESKNAYEKASEIANELAPVNSLRLGLCLNYSVFYYEIEKMPDKACMLAKQAFDDAIKDIDVLSEEHYKDSTLIMQLLRDNLSLWTHREESNKDYIDERAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZM2</accession>
    <name>L7JZM2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993817">
        <property type="protein sequence ID" value="ELQ76755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0248"/>
    <dbReference type="HOGENOM" id="CLU_1173114_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZM2"/>
    <dbReference type="OMA" id="CVFEDFL"/>
    <dbReference type="OrthoDB" id="2191894at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="237" mass="26933" checksum="03AAB89D8DB27D33" modified="2013-03-06" version="1" fragment="single">VLIIINEDNSTWCNLNTLLFSNTFVPMKGFFNVGSLLSKRLNILKKHSKTLTVTPAHINTCRFFLEVPAFTNHSFSIDSQALCRIARQSFEYELKNGSLELKDCTGSCTLTHKIAVGEPLHTSMHVDEPLISFECPHEFVKFVLKLEGRSAMEMNVRDDGTVHCEVHDVVDYDFTFRMCKVLISNVESVDVKVRVGELLFMEDVLDNTMVFCVFEDFLLVYCYDQGSTLAVKVNLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZR8</accession>
    <name>L7JZR8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZR8"/>
    <dbReference type="FunCoup" id="L7JZR8">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0788"/>
    <dbReference type="HOGENOM" id="CLU_074889_2_1_1"/>
    <dbReference type="InParanoid" id="L7JZR8"/>
    <dbReference type="OMA" id="GWYVVCY"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030137">
        <property type="term" value="C:COPI-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="168" mass="20152" checksum="D7AA06A91256B6AE" modified="2013-03-06" version="1">MIVAKFQYYLDKTAPKKLERWVFFSCVLVLYFIRILYIQTHYLVTYVLSIYLLHGLIGFCTPQEESIPDPFDNIDEEVYIPQTVDDEFRPFMRRLPEFDFWWLSVRLVLISFLTTFSSLFDIPVYAPILVIYFIVISLLTAKNLYRHMKKYNYNPFYVAKESYKAGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZS3</accession>
    <name>L7JZS3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein interacting with poly(A)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993803">
        <property type="protein sequence ID" value="ELQ76939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZS3"/>
    <dbReference type="STRING" id="72359.L7JZS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0063"/>
    <dbReference type="HOGENOM" id="CLU_076170_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZS3"/>
    <dbReference type="OMA" id="VKDWNQF"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="290" mass="32427" checksum="6A66067ACFE64F5E" modified="2013-03-06" version="1">MPDSVKDWNQFEANERLFGIKPEFNEADYTTVLDKNSEFYLKNVARAKKIEHDILTSKCGDRHRMEERGLIECENEEDRYSAVLYKKKGRKSGKKGEKETERSWSEGEKKVISQVEGRKATTLGNDTKSVSHGGEKKVCHADVTAQANDTKSVSHGVEKKGVPHVDAKKADKVNENAVQDGSHTDRKVPHDTHKKHAVDSENAQADKPCEGTSNDKLSKPKEDTKGPVSLKGVSYKKNVSSTFKTIKEYIESITSKFTGSLVAAGRWGNGDSYKIINDDKPVKNLFGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZT0</accession>
    <name>L7JZT0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZT0"/>
    <dbReference type="STRING" id="72359.L7JZT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0204"/>
    <dbReference type="HOGENOM" id="CLU_1807579_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZT0"/>
    <dbReference type="OMA" id="XALVEES"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="16560" checksum="16BE8C9DF79A5FB7" modified="2013-03-06" version="1">MPRKRKSFIEKYYKFALKKNSKTNCVRISLPFTIKCTFCGTFAFKGSKHNALKKKAGTQMNADSFVFFIRCGKCNNEMMIQTDPLQGKYTEYGGCKALNEKEKTDDYVERSERIPSASSVIQKLKMNKKLEDVEKEITNELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZT4</accession>
    <name>L7JZT4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZT4"/>
    <dbReference type="STRING" id="72359.L7JZT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0757"/>
    <dbReference type="HOGENOM" id="CLU_1687967_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZT4"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="8">
        <location>
            <begin position="72"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="156" mass="18625" checksum="F60900A45D5E11F2" modified="2013-03-06" version="1">MHILFANLEQKFYGITFKNHYSLVIPDKSKKKREVKIEEQDRKSTKVEHKKMKDENFAHRIDTIVHAVGDQKIEYYRLVVDPNSFTKTIENIFYLSFAIKLKKVKFCPEDGKILVMKDVGDKEPNERHINHFISSIDYVEYKRIIHNLNIKKPFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZZ6</accession>
    <name>L7JZZ6_TRAHO</name>
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        <submittedName>
            <fullName evidence="5">40S ribosomal protein S3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="L7JZZ6">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0096"/>
    <dbReference type="HOGENOM" id="CLU_062507_0_1_1"/>
    <dbReference type="InParanoid" id="L7JZZ6"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="226" mass="25863" checksum="B67AC63CF96AC0E2" modified="2013-03-06" version="1">MAIKADNKKQLKASKKQSKKKEKDSFTKKEVYNLTVPSSMFMTTTVGTTILTKQSTAAITERKLRGRVFEVNQGELQGNSPFRKYKFVCTKLTGRDLKSVFNGMELTTDKQKGLVRKWHTLIEAVSDVTTSDDVKLRVFTVAVTKKPALWTKKHCYAKSSQVKEIRKAMFDVVKEEMEGQSVVEIVRKISEDKIDKRIEEMGSLIFPLQNCYVSKVKVLKRPKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K005</accession>
    <name>L7K005_TRAHO</name>
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            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">THOM_0349</name>
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        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi incertae sedis</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K005"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0349"/>
    <dbReference type="HOGENOM" id="CLU_2078768_0_0_1"/>
    <dbReference type="InParanoid" id="L7K005"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="13489" checksum="96314F9BD34AEA72" modified="2013-03-06" version="1" fragment="single">VEQWYLAWEKYVAARLAPLQRVIDHALKDVPACGSSYYRKAAYQKLRIVCVAMWAVKSRTCAFLKWKANRTTIGELMNQPFKCSSATWITGTSFGCTVCYTVKYQPHNVRQFKLSSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7K007</accession>
    <name>L7K007_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K007"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0355"/>
    <dbReference type="HOGENOM" id="CLU_790326_0_0_1"/>
    <dbReference type="InParanoid" id="L7K007"/>
    <dbReference type="OMA" id="MSIMIMN"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978920" evidence="2">
        <location>
            <begin position="18"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="351" mass="38639" checksum="AE0575852989A9A8" modified="2013-03-06" version="1">MLFLLFLIQSLVRTANFSRVLRNDIDLTKKHADLIGKGVAIFNVHSGDGNQHTFVLTEKLLSKISYLDEWAELRKTFMLYQRSQDALLKSFDIFYESYIHSNKKSFKTGHNMSDIIETSFERGKEVNELIKEMVADRLEKLPASNNSSLSQLSSASPKASNSSLNSSTPQKKPQKTITTPGRPFTDSKIPVPCSHKAQKTPTTQRRTKQSYTSTPRSGSNRTPVTPPVSPISESVSSLTCAPNLCCLKNMSIMIMNQIDLCLAQVRLQTDLLNNGRDESKPNLGDMSSNTQMNGVSSPHSGSSSSLSDQPQSLPSSSEQKLIALRTLSSIQAHLANALKEFKKLIGSSLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7K010</accession>
    <name>L7K010_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative PWWP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993805">
        <property type="protein sequence ID" value="ELQ76925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0079"/>
    <dbReference type="HOGENOM" id="CLU_376061_0_0_1"/>
    <dbReference type="InParanoid" id="L7K010"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="202"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="738" mass="83321" checksum="7BC14B4517F67D2F" modified="2013-03-06" version="1">MPSNTQKNETDKETTNPHEKVVHDTIAGCVNNADKNNNADNTMDRNAIEECKMKENDQNAKRMKNKENDSVPVKKDKNTKEPKTVNVPVKKDKNIKRTNSSVSSNQNTSTLPEKDQTVKRNKSFTTSTLPEKDQTAKRNKSFTTSQAPSKKLNPAQPDQQIVAQQQSARIPPSNSQHSKSKATRNNQHNTKSRSVAASKFKPGDIVWSKYDAYPPWPSKVTSHAITAQLQKHYRKKGVGVLFLGRELSYGIVPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXENTKNVKKIENVNEKDKNKAKDTKNEKMSIKDKESTSRQKTAKTERKPGTVNKTKQNNDESTNTKNEEGKTVKGTDSETNANRNVERNDKEMVSNNKIEEKMRYKESTVGEVQQTLEDEWGTYLDRVMNANDEEKERSNDDTAKETGGNEHVDKNGRADRNEHEKEIVGGKKEKENGKLNEGKKEKLGKEENVVEQFKQSVEIKKEENNKTEHNEDKTPCVDDTPQNIAAMPNDHLSDRIHHSDPQSITHSLKIILKTYPASTSGVNNLFVFLEKQSDEFFMNNVDTVRVLYLIAYAAFEVDPVGIKSRSARLIKGRMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K024</accession>
    <name>L7K024_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K024"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0370"/>
    <dbReference type="HOGENOM" id="CLU_837250_0_0_1"/>
    <dbReference type="InParanoid" id="L7K024"/>
    <dbReference type="OMA" id="WPILIYF"/>
    <dbReference type="OrthoDB" id="2194671at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="332" mass="39115" checksum="21E978102B21F280" modified="2013-03-06" version="1">MVKMLNLIGNETLWPILIYFSYYDVFYRNGAECDVCNSILLELKYELEKNETNQVVSGTFEASNSETNVTNALLYKRDINLPYLFSTNLYLTLNNNITFLVQKKIFTKIKSETKLNEFLAKSGISIQMAKESFINLCKKYKDLIYQTLPQSFVFMKKYDNDVKITGIESYYLMLSYLFYEKPYFCVQSLHKKKYIDLTVTCKKNTGYNGQRINLENGFDDNIRNFEQSQDYDEKNASKSRTSAGSYSLKEKNVYFLLMHTFKENIKKIKQVNNVKILFLSTDTNNLVFIKELYRIFVLFFNLLGISNRFIILLEKYDKERALIYGKKKKAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7K027</accession>
    <name>L7K027_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K027"/>
    <dbReference type="STRING" id="72359.L7K027"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0627"/>
    <dbReference type="HOGENOM" id="CLU_061634_0_0_1"/>
    <dbReference type="InParanoid" id="L7K027"/>
    <dbReference type="OMA" id="MYTGNRW"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="123"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="237"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="386" mass="45448" checksum="68C9764B892BDBA2" modified="2013-03-06" version="1">MVSAHLRNLQLRGESDNSSIEDTIQENDLNSLSIQNMLLDENQEYNGIPRHDDESYKYRGSYKKRKEKRKKKSEDTKKQPSNRRIVNLPASQPYIRIVDGEERLCFKYNTKISETALNAMPRTELEDNEFCVRFDLESVDITKLNEKFKMDNCVYPRANVPFEMYTGNRWEYETECNMLAWQFVSLNPILLYGKKGLIQRAVDSYRNINKQSRGRRIVKQDHFNGILKRRHSDLTPQNVTIHWSIKGVNRKCKVRVDVENVDYDKIDIDFKCKYAVYSDEFDDKSFGLNKWESNNADNILAVKIAYLNVDNTTFWNAIKATDKATVLKKAVEAYKNRSEDYVSEEDEEKIELSDIVVDTLNKVYEDEKDENFYLFDVKPKEEKGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7K053</accession>
    <name>L7K053_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C4-type Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K053"/>
    <dbReference type="STRING" id="72359.L7K053"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0412"/>
    <dbReference type="HOGENOM" id="CLU_103055_0_0_1"/>
    <dbReference type="InParanoid" id="L7K053"/>
    <dbReference type="OMA" id="TCNIQDN"/>
    <dbReference type="OrthoDB" id="2190013at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="241" mass="27190" checksum="84C6253536E75B5E" modified="2013-03-06" version="1">MAKYLTTKISDPMSPDTCNSPKQVEIQCTQCNNPAFLKTMRVDTPGQCAQILSTYTCPTCNIQDNAILPYEDKNSRGGIKITCKFTNKDDLKRYVCVFQNTILQFKKDDFIYEYSSSMDVTTVAEIVLRNAIDEIAQMWNIKKKTFGSVFDLRQELSNSSASLSHSGSVTSLESIQDVDNAKYAIEMLQDMVSNSGFVMELCDPSGFSRVAPVNKMLGECTLDDLNTFNDEKVKHEWINRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K089</accession>
    <name>L7K089_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K089"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0550"/>
    <dbReference type="HOGENOM" id="CLU_1840007_0_0_1"/>
    <dbReference type="InParanoid" id="L7K089"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="140" mass="15285" checksum="617EBF8FCCC6A43E" modified="2013-03-06" version="1" fragment="single">VCENRVICSTGDCSLNKIGVPVGIRNQVITDESCSLKFNRVFEAKLVQDCSTSRIESKVSHNKSFNALSNQMSTGANEFNDKRSPDFDILLGSSGNINSSDVVPYSCASCSRKNEKHDKVGYCGSVSEATFIVFMMLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0K4</accession>
    <name>L7K0K4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">U4/U6-associated splicing factor PRP4, transposable element containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0K4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0083"/>
    <dbReference type="HOGENOM" id="CLU_2518845_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0K4"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="9535" checksum="D9535BD89001C4EA" modified="2013-03-06" version="1" fragment="single">VIRDRKEKAVRAYHEMRPFLIRKFVPAPIKMLLVKSVLLPIATYGCELYGMSTARLAPLQRVTDHALKDVLSCGSTPGRGVSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0K9</accession>
    <name>L7K0K9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0K9"/>
    <dbReference type="STRING" id="72359.L7K0K9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0108"/>
    <dbReference type="HOGENOM" id="CLU_410604_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0K9"/>
    <dbReference type="OMA" id="EFELWLC"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="522"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="628" mass="72423" checksum="462504E7D499D6CA" modified="2013-03-06" version="1" fragment="single">VINLKQYTNRTIKGKCKCLFMKSSNILRMVSRGVFLLSLICFYRQQKHDELVPARLGENEQGTMNVVGEDSVSKVFIGLRRLQMRISCCFSEVMKNEKIQIVVRGIEWLDERVTGAIDRYIGGKRTKAVVRGISMLEKFIGDSMDLCMNNRKIQIFKRRLEWSIIWLLSNTVKCLDNKIEMAICGVMRTKDWLSNKFIELSGAKVKMKAACGVKKIQKSVFVWLVRYLGTGTMKNVFFNFMAWCKTTTNSVYRWSNKVNMRHLITNFIEWQTKWTSRLIYHANKVDLSALRPAAEKSLADMAGVVYRYVNRGKMRETIKSVKRVQVAVTKKVENWIERTGIRTVITNIVKLGEGHACTRMIEILQAFRQGAVSKWIIQKITERHIIYIQNENQFKEIRGMGMTIDEELKQKMDSILKKNFEGNADVNNEEVVEEDGKKVLDYGVNHWIGKRTSESTSFTSTVYNTCTLIATKMLVWSIMLGQKWSGNLNRVIRRVEHGSQVEVIHEKKGDGGGCAITTSAQNKKVREELGRGTWRLLHTMASKYPINPEERDKKNIIQFLFLLAKLFPCEECSMHFQKLLNDHAPVVNSRKEFELWLCNAHNIVNKRLGKSNFDCENIGNVWGCGCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQV8</accession>
    <name>L7JQV8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3259"/>
    <dbReference type="HOGENOM" id="CLU_734041_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQV8"/>
    <dbReference type="OMA" id="VELYAYE"/>
    <dbReference type="OrthoDB" id="10346589at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="377" mass="44031" checksum="A26DD846AE519A31" modified="2013-03-06" version="1">MTTSNRTNKRDGQDIKKKQKECNRQSKRYFEDDLEGDNNVINNKYVCNNLNNVLYRSHDDNDAVDNVVTGDILTKMYNLTNDPSDRLFSDLSYYNHLFKTVFLNHTYFNQYDISYPSDNLKNDLNYYRNTVKKTMPFKRIYNSLISQYISEAQLFFDENSFVEVETGKVKDNYEHSVIGAANSYKNIKITDVKKSKVIEYPNSLISNKNTIFITDQIYNKLRSKNFVTNFTVKELSHLKITKFTDIKVKKLNYKEAVELYAYEQVSQNIKGSECKIYETETQKIVIVCNSSFQHHNKTKRIYSTPDDAKNVEFVLMDDVIKPVDILGKKKNYLDWLNGIDLVEGEYSSVGGKIYRIESEGFVFSAEGFVIEEVNELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQV9</accession>
    <name>L7JQV9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RasGAP SH3 binding protein rasputin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQV9"/>
    <dbReference type="STRING" id="72359.L7JQV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3228"/>
    <dbReference type="HOGENOM" id="CLU_1316291_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQV9"/>
    <dbReference type="OMA" id="ISHEDNV"/>
    <dbReference type="OrthoDB" id="2189602at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="24098" checksum="C426471210BCA937" modified="2013-03-06" version="1">MTDSQFNTPKKFLNEYYGSLCSSYQSIIPFYDSASQISISHEDNVAMLSNTSVMERLLSLHHKKKVIKVLVSCYEHHMLSPHDFLVCVLGQFVYHDNSTVRFSHTFIVDCSNMFVIKNEILKVLDEEVIYKAIDFKEKVSNVSNTIRIVRGLDKNRNKLVVDFAKYGNLVAVEVDKNDVLVEYEDEEMVKSLVNDVSFIKSKGYKVEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR39</accession>
    <name>L7JR39_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_3134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="1"/>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR39"/>
    <dbReference type="FunCoup" id="L7JR39">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JR39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3134"/>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="InParanoid" id="L7JR39"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="9">
        <location>
            <begin position="196"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="10">
        <location>
            <begin position="568"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ73938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="656" mass="77073" checksum="6E9EA2D3987FFAE2" modified="2013-03-06" version="1">MTQDVNEFMKNLKISDSLKDQLAKKEYAIDNLRRIAKYTNIDKNIYYNMCLAITDLEDVYVKEIVNLIEQKIVINDNMLNKCIELGKGKKCGEEEGALTNYVKSISFDECKLRKVAEKFDNLKDVMNYLSKDDEMAFYDPKRAISVLKSFNVKSKKIERKGILNEGKLRYLHKAGENPQISEEILQAHLKRTDGEIITRFPPEPNGYLHIGHAKAMYLDFNFGNRCILRYDDTNPKNEMAEYYESILEDVRWMGYTPWKITRASDYFDELIDFARRLVRDGKAYVCHLSTEEIKAQVLSPYRNRSPEVNLALFEEMISGKWKEGTAILRLKMDMDSKNMLMHDLIAYRIIDKDHLKADKKYYVYPSYDYTHCINDSLEDITHSFCSREFFSRRVSYYWLLDNLRVYKPVQWEFSRLNISNTVLSKRKLNALIAKGIVMGWDDPRLFTLRGLRRRGVPPQAINAFVEKVGITFNESIVDVRLFENIVRDFLKDQRIVNVIYDPIEMKIEDQESILIDGDDFREKNTEDFLRLTYDQPVGLVNKYAVELVSIDDRLLKVRKTARTFKSRIHWLTKDAQNVKIRVRELSHLFRSFNPEEKDFLEDVDPDSMQIVEGLCEPGITDVKVGEVVQFFRKGWYCRDEDENGLMTFNKTVGMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR62</accession>
    <name>L7JR62_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding Cassette (ABC) Superfamily</fullName>
            <ecNumber evidence="10">3.6.3.19</ecNumber>
            <ecNumber evidence="10">3.6.3.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_3169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.19" evidence="10"/>
    <dbReference type="EC" id="3.6.3.29" evidence="10"/>
    <dbReference type="EMBL" id="JH994097">
        <property type="protein sequence ID" value="ELQ73929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JR62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3169"/>
    <dbReference type="HOGENOM" id="CLU_020421_1_0_1"/>
    <dbReference type="InParanoid" id="L7JR62"/>
    <dbReference type="OMA" id="IYVENIF"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ73929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="590" mass="67076" checksum="5D92135907C157E9" modified="2013-03-06" version="1">MILEWRNIDISVLNHNKRYKEKRIKLVSDACGRAEEGLLAIMGPSGSGKTTLVKALAGRLSKGSSSTGVVKLNGVERNLETWVDMIGYVDQDDTIYEILTARQTVEYAAKFRLKDSNINVGEKVESLFKKLAITHILDCEMRNLSGGERKRVMIAVELVTDPKIIFLDEPTSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPSLYHIMLLFTRRCKLDLFSKKNIISTLMILIMVGGSLFIMKLVKNNSLKKKEGMIRIIGAFYSDTKHGAFLKDLISLDVSSYAFYSISATISFIPIITGMAFNSEHKMVKREIAVNTYSITSYYFSVLLFEYLRCLPFMIIFMIGSKIIIGQMVDLMIMFIYFLMFTTLIVAYLFYGSVLRGTKKVILVYGLFIIFNNAQFCPVIASMRKDENLSKIFMISYLLNLCPNYVLGVCPHIHVFTKMKDRYAKLVDENGNNLYELLVSDAFKELIKPFKSLLLGYEIPIIFNYLTCVVLIIVYMLLCILMLSFHLQAGYRIRLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRE5</accession>
    <name>L7JRE5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ74004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRE5"/>
    <dbReference type="FunCoup" id="L7JRE5">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3097"/>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRE5"/>
    <dbReference type="OMA" id="CASHITN"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000008">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="222" mass="25107" checksum="5F6369FE681983AB" modified="2013-03-06" version="1">MIGCSTIHTGIVVHFALLSSSIVQQNVKNLFFKIFNPMVEFYTEKKVSIPEGCNVTINEKVLSIECNGKRVVRNFSHLVLTMDIHEGNIRLRLWNARRQERSKLITCASHITNMILGVTKGYEYVLKAAYVHFPISFDIQDSGKKLVVKNYLGEKTSRYFNMRGDSVARLGTDKDTVVISGTSIEDVSQSAGSVQDNCRPKNFDNRKFMDGIYISRRCVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRF2</accession>
    <name>L7JRF2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3235"/>
    <dbReference type="HOGENOM" id="CLU_2055398_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRF2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978762" evidence="1">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="13866" checksum="4BAA0A163285FBBC" modified="2013-03-06" version="1" fragment="single">VLYINIGYALRMVHFLSLFLLFIISSAGGDSMIDTIASVDEYMDLDLFLVTVMICDGVDQVDLLHRPSKTSLVDIKKRTNELLDQLGVKRYDVSKHQSSTQYFLDHMINLQKKRTKKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRJ9</accession>
    <name>L7JRJ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3193"/>
    <dbReference type="HOGENOM" id="CLU_708201_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRJ9"/>
    <dbReference type="OMA" id="DYQFLMG"/>
    <dbReference type="OrthoDB" id="10446288at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979070" evidence="2">
        <location>
            <begin position="18"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="390" mass="41826" checksum="04D7859D8CF50929" modified="2013-03-06" version="1">MHKLFAMFLFCLRVILCTDGAPCKPTVSWVSTVAADNTSVLKNSTLTKEELNNTLINFFNTSVSPIVDKAVKQTTENVDKSVIQLCNHISSLYTSTLTLLEELKKNTAKVHFDTSAPKSNSGKTPADPFPGYLEDYQFLMGIVTRTARCGGCCTCQKGEMCLFYVFIQLYLIINNNPNWQPPNISSLVNFGGISTTKNSVALEIVLQNLGKKRCTTCILCQEISRDQKLSFMFNTDVISKLFGAGNSADKSMLINLIMSGGMGSRNLDNQLNLLPILMSFVESGKSDRNPTPTSTCPFTGSTGKNGCDKNVTTGPSCPSQALPAQPTCPTVSSATVPPTGSIPTSTTTPASTQPVYGIPLAPSGAPVHHVNPNVTLGSKPAYGVSYGSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRP6</accession>
    <name>L7JRP6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3000"/>
    <dbReference type="HOGENOM" id="CLU_1983126_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRP6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="126" mass="14663" checksum="75E00FD1B5CB36B7" modified="2013-03-06" version="1">MSAEANPVTTVENPTPSYLKTMLKIEEDSNYVCKLREQVQKEELIELLHVSFDLLFLLFVVAVTMYLGIKFYRDRRLQRRHIINSPLRLSSRSSAGLSDQDRTDTMMANRQAIIRIRTTSERETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRU5</accession>
    <name>L7JRU5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2911"/>
    <dbReference type="HOGENOM" id="CLU_159444_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRU5"/>
    <dbReference type="OMA" id="HVNFVLR"/>
    <dbReference type="OrthoDB" id="2186267at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="125" mass="14718" checksum="93B14F07562534EA" modified="2013-03-06" version="1">MLYRIMELISKHDTFNLFTEYPSTNNLTTITKKLSHYTNIKALENDILAIFKTVMNAHNYNSIYVAESDRLSNLTRRVFEEAKELKKEEFKVDYTDDVIRLYGESLESFVDGVELVNEHVNFVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRY4</accession>
    <name>L7JRY4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trehalose-6-phosphate synthase component TPS1 subunit</fullName>
            <ecNumber evidence="1">2.4.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.4.1.15" evidence="1"/>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRY4"/>
    <dbReference type="FunCoup" id="L7JRY4">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3285"/>
    <dbReference type="HOGENOM" id="CLU_390882_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRY4"/>
    <dbReference type="OMA" id="FTWIGNI"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="721" mass="82370" checksum="CB6510ED4E37DDDB" modified="2013-03-06" version="1">MRLIIVSNRLPISIKRENGEFVYKRNSGGLVTGLVCVAKSIPFTWIGNIPGNFTQEEQQEIRTNLNDNHSSIPLFVPEALNKMSYDGYCNKILWPLFHFFTDIVVYDNYEYYREYNEMFCKTVLENAGANDIVWVHDYHLMLLPALLKKYKPSLRVGFFLHIPFPSFETFRLLPEHREILLGILGADLIAFHTLVYSHNFRQCCEAILGNLNEQEKQQLTFVKPDDSNVSCPECSSSEIDRNFKVLTVVCKRCVNKMGLSGAVKECEGNQMSLGAGKNDKKDRVKGTNYLDKSVEDIDRACQECVYAGTQYEPESRLQLDRNRNTRKEHKGGVLDDIKLTKHSIAAIYDALRSSTTCDTYLQREKQKSDQLKDIVAVSSGKDNTCMECHKLNENLPRISNLRCEECRNTEGIAQETDSEIESINDEKANIDGSVQKYTEHQINMCKCVGAPTSEPDDASHRKRSKNYGRPVCVECAFDRIRIDDREIAIKRVPIGIDPNHFRSCLEKKETIAFIKKYKEMFQDRFVLLGIDRVDYIKGIPNRLAGYEQFLRKNPEKKTVFIQVGVPSRTTIKEYNYLESAILSKVGRINSKYGGVTDSLVYYLNSSVKFEEMCALYSIADMCLVSSVRDGMNLVALEFVACSQNNGILGLSEFAGTASTLPGSIFLNPWDTETIVRAIEEGIKMDSGERMRRYKVNFENVTKFTAEKWAETNINYLLNYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS00</accession>
    <name>L7JS00_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA helicase PIF1/RRM3</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS00"/>
    <dbReference type="STRING" id="72359.L7JS00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2891"/>
    <dbReference type="HOGENOM" id="CLU_001324_4_6_1"/>
    <dbReference type="InParanoid" id="L7JS00"/>
    <dbReference type="OMA" id="QGKCENG"/>
    <dbReference type="OrthoDB" id="2193682at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF48">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="111" mass="12834" checksum="DF12A825C8C26851" modified="2013-03-06" version="1">MIVTVSKKSNRAIILKVDMAPSETQLPFILKRRQFPVLLSFAMTIHKSQAQLFDEIGVYLHSPVFVHRQLYVALPRVRHADDIKVYIADNGYQDKADNNMVYTRNVVYNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS34</accession>
    <name>L7JS34_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2870"/>
    <dbReference type="HOGENOM" id="CLU_1587747_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS34"/>
    <dbReference type="OMA" id="ENVILCA"/>
    <dbReference type="OrthoDB" id="10352608at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="168" mass="19877" checksum="D4B517DC6DF579B9" modified="2013-03-06" version="1">MVVDRLLVLYFDSYCMRTREIIIEILRNTRNIQIDRYTHQLCEDITCENKEIRRVGVKFLKRLKCVVNDENVLLCARKVDRKAYLSILKNNINIANQVYRDGVVKGALPNFTVKEHVKIAKINFYVQSLLIRKIRQEGDSELVRQLKERIPVLSDEVDNAIKRMRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSB3</accession>
    <name>L7JSB3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2736"/>
    <dbReference type="HOGENOM" id="CLU_1038955_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSB3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978979" evidence="2">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="268" mass="29183" checksum="B00139EF4DF38726" modified="2013-03-06" version="1">MLFLGAILHCVLCVMASNRDADQSLKEPLIKSDKDGNKSNTEIVKVDMHHAKGENQGAKPHWSKTLKREPARKHFSVTPVADPSGLKTNKQQDTTSQDVVDGSSSTPRTTDAENQEQSSSTAPSANPDTFDSPTNEKEAPVTSTNDDSNSDNPQYKHRNSSDEGSNAGCFGCFGRIFTSKSSKKGPGKISNGYVPVDREEQKLNNQRDSESTVNKETSTSRSPEEPHELQPSTSQSLSPTSSENTDFVDVNLAKKPLIESKSKEGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSL8</accession>
    <name>L7JSL8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSL8"/>
    <dbReference type="FunCoup" id="L7JSL8">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2791"/>
    <dbReference type="HOGENOM" id="CLU_152663_2_1_1"/>
    <dbReference type="InParanoid" id="L7JSL8"/>
    <dbReference type="OMA" id="ICSCTYV"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="6895" checksum="7494D6ADDAE3C19A" modified="2013-03-06" version="1" fragment="single">VLSICTTTYIKRQFPSLIGRSNKGMSSVFYKATVIGERLSPYVSLLCIFFAVEMFLSFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSP4</accession>
    <name>L7JSP4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoskeleton-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSP4"/>
    <dbReference type="STRING" id="72359.L7JSP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2593"/>
    <dbReference type="HOGENOM" id="CLU_761150_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSP4"/>
    <dbReference type="OMA" id="MKNVRSR"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF93">
        <property type="entry name" value="RESTIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="364" mass="41875" checksum="13A33040ABFD6089" modified="2013-03-06" version="1">MDTITLQINDKIYLGKWGMGTIRYIGTVKGDEGEYVGIELDIPKGKNDGSIDGTKYFTCKNNHGLFVPIDKLKKMIKGRQEPGHASVIMNKYKDRSIWNISDIDKKYVNQPILKGSENGNLNLKSDGINEEEGSKQQDALKSYNYKDNKVINDRNRTSVLNKEEVGEEKSVSKNWQGSPGSVNCEGKQFSIALEKMVDENLDNMNRDKHPHLDYKTLKMIYKTQKVYSDSKIRDLKSQIAELKKRCSENDNNKLISEVDRLRKENLKLKSSQMKNVRSREQIDEFILGMIKDCLKMKRSVDEALEILNRCSQKKIALSSEHINMFYLVKNLLFAILNDDEEKIDVYFEKFSAILKMNGIECSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSX8</accession>
    <name>L7JSX8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2446"/>
    <dbReference type="HOGENOM" id="CLU_850426_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSX8"/>
    <dbReference type="OMA" id="EMATPSY"/>
    <dbReference type="OrthoDB" id="10312507at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="327" mass="39502" checksum="4CD4FC6EE7412FDB" modified="2013-03-06" version="1">MKIVDRILKHREKIIKNMSRIKAITLLLATVALFFIIPYENTVYNKDSGYDYITNLNHVYFDEKTYDEFVKIEDHFVFELQPSKSLCETIIVYGRKKDLYFFVRLASSIKKMFCQRKNVKIILSDDYFEMATPSYFCEIDLCFGDETRVINNFMRHLSPNSDFFFITSYFFTPESSFNFRDVLFNEFSYRNVNKVYITIEKDLNSTKQFLTYLRALFNIDSHLFGTYYYFTFGNRYWRMENFGPFVFFTALYFFVDVFYGTYQRRPPWILLYFVSPLFCILFFREDTINFAIDIVFFFIINFKVGVFFALIAYLKAVKEMIYTKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT44</accession>
    <name>L7JT44_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT44"/>
    <dbReference type="STRING" id="72359.L7JT44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2585"/>
    <dbReference type="HOGENOM" id="CLU_1476150_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT44"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="183" mass="21984" checksum="124396F6721B0750" modified="2013-03-06" version="1">MYRDAKLVHCDLSEYNLLYYDDKVYVIDVGQSVDVTHVYADVFLVNDIANVNKFFERKGVMVESVRSVYERVTGKKMHFDIKGCEINKLGFDTGRLLELCDDREQCADTRLLYDMNRTENVHEDVKRRKDGQFTKNAFLTKEEKLERRRKFKDERKMKRMSREKKKKETKVIKRKKRVHRTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT67</accession>
    <name>L7JT67_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3148"/>
    <dbReference type="HOGENOM" id="CLU_1090657_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT67"/>
    <dbReference type="OMA" id="MECASSC"/>
    <dbReference type="OrthoDB" id="10274770at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="255" mass="27936" checksum="2D98D799E300A1B4" modified="2013-03-06" version="1">MNSTNENDNNVIAENADKKPGLKLPEADETDRISVIVEQDASGKKKINIKMDNDDDERNNKQDDRGTMECGTNCKINCPNFCPAADTFRDKMATCGIILSGILVTVLVFIGLASCVRIYRDVTSNRHKSGDYESDTDNDIPIYGTEGTFRSLNTKLMAFGRSLTAKSEKSDSDAEPIVEFPGTPPPSDDESSTNSSSLGISYLFEGTDGFCTELCTQDNQNETKIDIHNYSQFSDGLQVSDGETSIDISEGVYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT82</accession>
    <name>L7JT82_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_2447</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT82"/>
    <dbReference type="FunCoup" id="L7JT82">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2447"/>
    <dbReference type="HOGENOM" id="CLU_023471_1_1_1"/>
    <dbReference type="InParanoid" id="L7JT82"/>
    <dbReference type="OMA" id="MPIQWHA"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ74535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="347" mass="40094" checksum="C537E60AD540B615" modified="2013-03-06" version="1">MNFLANIAVSETVLKRTYAGAIMFAVLHIVLKDNVAVYLFVFVLKTFALNEVIGIKEENLRKKYRFKYLLWYFVTVSDLFFSKSIARPFYIFLLSLDFPVTHAFLCFSLYILGIVYFIVNLRRGVLRKQFLQFSITHFAIMMINFPVHCVFRNIRVGKFWFVYPILLVAANDIFAYVTGKLIGRTQLTKLSPKKTREGLIGGFIFTVIVGFFCIYLKCQFNIYEGVYDKAILAKTVTRYKIPAIYLHAIVLILFASFVAPFGGLLASAFKRLFKMKDFATYLPGHGGITDRIDCQILMGIFTRYYLSAFVLKRTTTVDKLTDMIIYNYSANEMKKLVLNIVKHLVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT85</accession>
    <name>L7JT85_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3112"/>
    <dbReference type="HOGENOM" id="CLU_641235_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT85"/>
    <dbReference type="OMA" id="IFSMTYK"/>
    <dbReference type="OrthoDB" id="2191542at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="429" mass="50736" checksum="9F890442BA26C003" modified="2013-03-06" version="1" fragment="single">VMDVSYVLRENDDNLTVSDMYNEKIYYAKDSSMLIYDIYTNYKDTICSFESRIDDIKILKRNIYVFRGNKCDIFSMTYKEIKGTLRMKSLPVKIKKTSDIIALLSAEGTMHIIENERLINVRVYRGDEQVRILDFCTGDTSSFILSTGGEVFRSKNFAVTNRIFMNDPEKILPKCAFMEPLGVELNKERLYVLDGEGVHVFKVREHCLERLYTYKSTNMKALHSFENVFCYGDQLVLLDRVPYLLADEQIYTMLEDKAVGAANIYFTSSYDRQYEDEVKASELLKERNPDDRIEELFSKIVFRPNCTVEEYKTRIIDGIKSIYIELDSLNKSFVEKAKLVGDKGRAVKQKYDELFKRRKDVEEKLKMLNERIIHRVKEKENVKNPQLERMINELRHRMKTRKSRDYEDELKTIKLQNSIFKKYVEDIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTA8</accession>
    <name>L7JTA8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_3090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTA8"/>
    <dbReference type="FunCoup" id="L7JTA8">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3090"/>
    <dbReference type="HOGENOM" id="CLU_004174_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTA8"/>
    <dbReference type="OMA" id="RMCLAVC"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="17"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="513"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ73997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="942" mass="108798" checksum="7F7CC0D9DB3FBFEC" modified="2013-03-06" version="1">MDRKSTTKLQTLEAIEKIFKNTVEHGGEKRPKYFVTFPYPYMNGKLHLGHLYSFSKSEFMARYKCLKGFDAFFPFAFHGTGMPISAAAKKLCEGDQGTVQLLNSIGIKNTEPFKDARHWLYYFPPLAKDVITKFQSYVNWNHSFITTDLNPYYDSFVKWQFHRLKNYISYGKKETIYCTATNQPCLDHDRRTGEGVIPIQVKLRMVTMGDAYFCTRVKKGSHNKNEDQAVHTNSCTRVREGSHNKNEDQAVHANSCTRVKEGSHNKNENNTAHTNHAKTIVVGKTTRFIRAKINDHECIVDHWALENMRHQEFKIEVKEEVKIDKIAGHENYKFVYLDGDQPPVINFCDADDPSITYYEPEKEVLGRTGSKCVVALVNQWFLDYDNADWKRRVAECIEDMNCLPETKRMLLDALGWIDKWGFSRTFGLGTSFREYVIDSLSDSTIYMAFYLAKPELFSDLYGAERKIEPECLNYAAWDYIFRFSDVNPYSDEKELVLRRARCAFSRYYPVDLRVSGKDLIKNHLLFYIFHHVAIFPKDCWPRRIYTNGHLLLNSAKMSKSEGNFLTAEESIQMFGASVTRIVLADAGDFNEDANFSQALADTYVLKLHTFINYVESFIQEMIQGEENAECVDKYDEKGVGRYEEKGVGKYEEKGVGKYEEKGVGKYEEKGVGKYDEKCVGRYDEKGVDKYEDKIENARAAIEKKIVEFIGRYDEYKSSPCSRTDLSFADELLKDGTDYLVSRCDQAYEGMMYRDVVKYGFHEFKTLIELCVSLGCSKEAVLYAIKNNLLVMHPVITAVCDYLLEKYFNKTLSWPELSVKKGNVYLGLEWFKRFSKNFASKAAKTQKKNARIFVGTAVPEWKVQVRNVDPDDITALREFFTRFKVNPKKGMSFVKDSVVYDFDEHRLLSGLKSSLEKRMGVVIEIVTGVEGKGEPYEPVIEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTB3</accession>
    <name>L7JTB3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2380"/>
    <dbReference type="HOGENOM" id="CLU_1262301_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTB3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="219" mass="25194" checksum="15F67B55CEEF98B7" modified="2013-03-06" version="1">MKIHRCELLSSEGCAKKMKRSECTKECIQLALLSQESRKRNISEQEGDKIHDSRCSTRDVTAMHAKLLQLKLLKKLSQQSKTSSMLRLLHRINVKTMDDRITCNILLYNLTVLIHHSSLRIRQRVSIIFKKLCRFLRFSTENESEEQCNAYKNTHARVPNDDKPFDLLRLFKKNNNVTDGALIFALEDTDPQVRTNALNAIFPALVHSSAVITCIFVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTH0</accession>
    <name>L7JTH0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2319"/>
    <dbReference type="HOGENOM" id="CLU_2135418_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTH0"/>
    <dbReference type="OMA" id="HCAFFLI"/>
    <dbReference type="OrthoDB" id="10527225at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978720" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13391" checksum="38BADA7003AD1F8A" modified="2013-03-06" version="1">MDRKFYHCAFFLIVLILLSNVYKIRCQSTVEKKDQNAENDAGGASPIAEEVQGISPDSEEKDDGGMGGLFGKSKDKDQKKDKGSKSKNQSFFSKYKTYIIIALVVIVVIVIAGVVFGMFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTI8</accession>
    <name>L7JTI8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2355"/>
    <dbReference type="HOGENOM" id="CLU_2962543_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTI8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6799" checksum="B2AC1262BC40E169" modified="2013-03-06" version="1">MTTHRMTKEKKELLLEISDKLNITFNERMIDIALDMLEGGMSVENMIIILEEMRTDVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTM0</accession>
    <name>L7JTM0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase, (GNAT) family</fullName>
            <ecNumber evidence="4">2.3.1.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.1.88" evidence="4"/>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTM0"/>
    <dbReference type="FunCoup" id="L7JTM0">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2315"/>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="InParanoid" id="L7JTM0"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="182" mass="21257" checksum="10D7FEB97615EC93" modified="2013-03-06" version="1">MYKTVPFLPEDIFSLDLVNLDSTTDNYSLSYYLYYHLNFSDNMYIVKTEDLSSTCFLYTSKIVGYIIGKQERRGVLSMHVSSLSIAPTHRKCGLATSLMRILEALGNERNAYFVDLFVRCSNFKAIAFYEKNGYIKYRRVLGYYTSPEEDAYDMRISLERDGDKRYMVPVKKPVHAENLKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTM3</accession>
    <name>L7JTM3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994075">
        <property type="protein sequence ID" value="ELQ74107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2970"/>
    <dbReference type="HOGENOM" id="CLU_851434_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTM3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="327" mass="37639" checksum="BE8FDD673CE9BFBE" modified="2013-03-06" version="1" fragment="single">MCKTVLDEQDGNLLTKTDIDLRNYIHKLQLGNLSSDKPMAQNGMVNIDITSMFQTGLFENIMFRKLILRLCNAYFNISSLSLPAHELVLHCNDSTIEVKNKLPSILTALYIQNSYLEGVLESNHRLRVIRLYNIAAEHKLAVFVNEQYTTIEITNVAGQVSIPFVNKYREIFQIKNWKKFILRKNIAGTIHELNICNAKFIKNWKMYEEIKKLQLENVTCASNSTITISRDSLCLSILNCKCGVSLAESKFIEKLELANCKKIVEMIAYQGGMLRALRLIENRSDTHIFLNEGIEEIYVSDSVSAIQYVRHLITPRICSRATLYYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTP7</accession>
    <name>L7JTP7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2388"/>
    <dbReference type="HOGENOM" id="CLU_3242458_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTP7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="43" mass="5155" checksum="D8EFB3BC0B6FA184" modified="2013-03-06" version="1">MILYFRILKFLAEAYPKEDTYVIRTSNEKLVFIACKIIVLLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTQ4</accession>
    <name>L7JTQ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spindle pole body protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTQ4"/>
    <dbReference type="STRING" id="72359.L7JTQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2670"/>
    <dbReference type="HOGENOM" id="CLU_754784_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTQ4"/>
    <dbReference type="OMA" id="TGRHINS"/>
    <dbReference type="OrthoDB" id="2190654at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="205"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="368" mass="42611" checksum="F35966F3764D54C5" modified="2013-03-06" version="1">MDRRKMLKLLKTPESSFNLDSDDSFALKSAKPNILKKKVSDIINGLHEKHGDGNYKNDENERKMLNTENEEISDEKTNESDNEPKLHTDDTYCTEDVRERVEHSSERNDAMDNTALTGYDTINYERSIFLEKNGGVVSQLYQAARVVRNKLTYFLKQHFWVLLISVLMVYIVAYLNRTHGTTEEDYKKDIQLLRTQNKGLQDMISKLAVPKRTKRVFNVCRIEEGTVIDVPNSARPYYYGLVFKRTGRHINSVMSESLEPGDCFIMDGTTGHFIFRFTRPFKIVRVGIFHPMSKKKASAVRNIKITGMDESEKVELGEYEYKEAGAYQEFELHNDRSFSALDFNVLSNHGAKDHTCVYKIYIFAEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTQ7</accession>
    <name>L7JTQ7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_2276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTQ7"/>
    <dbReference type="FunCoup" id="L7JTQ7">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2276"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="L7JTQ7"/>
    <dbReference type="OMA" id="MPNEKEY"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="32"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="224"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ74799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="542" mass="61750" checksum="C401173BDD6DCFBE" modified="2013-03-06" version="1">MSGSFDKLKLTGETRARLETISITTPTNIQTDVIRSFNDDLIVESPTGTGKTLAYLIPIVDFYLKNRPKRITALILVPTRELAQQVGSVLASLGVKNTVIIGGTDEELNFEEILVATPGRFNKILLNSRTVICSRTNLSLHTLLKKIDFLVLDEADKLLSLGFRSQLLSITGQIKAKRNALFSATMNDDIASLCRSFLKSPKTIKNHDKIPLDIRYVSVDPFGKLKMLYDVIMRNKKVICFFLTCNEVDYFYSLFTALGVKNIAKIHGKMKQEERNAVYENFKSVLFGTDLASRGIDFLGVDVVVHFDIPLDPESFVHRSGRTGRNNKHGRALLFITDNEKKYLNYLKVKNINISEERVHENNKIDGNMHSLSTDIDDRVSKLENKEVTGKLNNKKKIDQQEMAIEHKQMKKNKLLGLDNGMELDVPLDEDVCKKENECNNNITIDDNQKEGLLNSENLQKSVFDDFDAMKKHLTDEILKLSVKAFVAHVCAYKEHKLRFLLDFKELNFDSLAKLHFLMKIPKMKELRGVKFEHYDNKQGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU07</accession>
    <name>L7JU07_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA-splicing endonuclease positive effector (SEN1)</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU07"/>
    <dbReference type="FunCoup" id="L7JU07">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2262"/>
    <dbReference type="HOGENOM" id="CLU_553905_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU07"/>
    <dbReference type="OMA" id="EHAHIAG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="87"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="226"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="306"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="525" mass="59613" checksum="CF4A118DC33E2C55" modified="2013-03-06" version="1" fragment="single">VVDSKQGSESCVTVRTRSSIKKPKLHGVLVYYDVCCFSSFFREYVALYKLQHFPCLPSVLASDNVKITPLVGDASLVENVILRIHGLNGSQQIAIKNVYTSAAFFSLIHGPPGTGKTKMIVSLIESLFSAPIISALKSKMFITNREPRILICAPSNAAVDELAKRINDLRMKGREEEKLRVLRIGVQNNIDDNLKMLTLDCIIEKELEERKNRAGLTNFEVTNSERTKRKFELLKRSNVVCATLSSSAKELIKVANIDFDILVIDEACQSVETSTLIPLKFNPTKVVLVGDPKQLPPTVISNCKPYEQSLFVRLQKTYQSVLLNVQYRMHPTIVEFPNQYFYDKRLQTHKSVKKRENPYQNVVPPISFIQVNGEERTDSYFSFYNVAEARYIGNIISELMKNVKNYDLSNKIGIITPYKAQMKKIKEVLLGIRKDILDFVCVNTVDGFQGQEKDVILISTVKSKNIGFLSDLRRINVSITRAKHSLIIIGNTKVLSTSNAWKSMLSHYRKKNLVFNHYKSIFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU30</accession>
    <name>L7JU30_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2819"/>
    <dbReference type="HOGENOM" id="CLU_702454_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU30"/>
    <dbReference type="OMA" id="RPANTHE"/>
    <dbReference type="OrthoDB" id="10347507at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979146" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44672" checksum="E24B395229086E2B" modified="2013-03-06" version="1">MRILLISEFLFALGGSVTYMAWEEDPSKVIANSHGYMKLMDKTKLTMNNVHNVRLFRENDSYVLRFGRSRLCYDNTKQRVKACRRQKMRSTWELVKTGLSYLVRQNEKCIAPTNTIESTSQQSELTLKDCDGPDVLKIQFNNSEGEILDVPTSKVGVTREVEPSGMRVLTLRKRSSINPVREVTTAGDVVVEHKPKEIIKNIKVVPKVAEPDVQVVEKQKVVHHGIPAVEKVVMPTVEDKELVLKNQEPKKLVIKEKPVAKTKEIVVEQEPSSMKRVTVDSEPDVTLVKPAQTTEVVNVPGVVETDHDTAVIKTKSPIKMIRPANTHETTSRRESAFQKEDEQFMRGTRDFQESIDDSLDKLVHSKSKKTTLVHHTHAEKCEYDKLTGAYRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU39</accession>
    <name>L7JU39_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ74998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU39"/>
    <dbReference type="FunCoup" id="L7JU39">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2040"/>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="InParanoid" id="L7JU39"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000037">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="497" mass="57881" checksum="A50231D84DB36A25" modified="2013-03-06" version="1">MTTIREKKKAPEFGLTHKKTENFSEWYQQLVIKSELLEYYDIKGCFIMRPWSYYIWNVVKESFTRDITRMGVDECYFPLLVTKNALEKEANHIENFAPELAWITKCGENDVEPVAIRPTSEAVMYPYFKKWLFSHRDLPLKLNQWCNVLRWEVKSTLPFIRGREFLWQEGHTAYYEKEGAEQEVLQILDLYEKIYTDLLAVPVIKGRKTENEKFGGAEYTTTIEAFIPVSGKAVQAATSHFLGKNFSKMYDVKIVDRCNNEEYVYQNSWGLTTRCIGIAVMLHSDDIGLVLPPRVSKFQLVIVPCGSLNGDVCAYIARIKKEVEDRGVRVFLDDRKNVLSGFKFNHWELKGVPLRMEIGMNDYNNNEVVVVTRMNRCKKRVSSTNIADYVVNELNTIHDQMYENAKNEQMKRMRTANSWEHFKCELSCNNLIMIPFCGRIECEEVIKEETTVRKNGCVEQQGAKSLCVPFENNERKSLQCIKCGEACDRYTLFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU50</accession>
    <name>L7JU50_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2050"/>
    <dbReference type="HOGENOM" id="CLU_409168_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU50"/>
    <dbReference type="OMA" id="HRNGDFF"/>
    <dbReference type="OrthoDB" id="10412670at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="672" mass="79226" checksum="29AC05F3628C05ED" modified="2013-03-06" version="1" fragment="single">VLHRGILDPEIKLEQKIKMWCILIDDTTNDQIKAEYIVASGIRTKEMMKVLFACDLTAEMIVKLFIEEKIRCHEIFVYVAENYLSGDVIAIEIADDGKISLSTDHEETYNGLNDGKNVCQAENKIETCEELNGCKDSTRTISSSFIEAFAEQFVRLRPKSIARILARCSKTIKLPEIMVTKNLLQRIKLRKGETLPRYVRTLCAQCAHNNNLIYECYKMIKNCRLEYNFIKELFSSDNEHIMMMKIKEMVKIYYRTVVKDREGAVTRVKEIVKNRKINFNTRNAVNNSEDENKRWYSTIQVPIYDEEVESVKTVTYNRVRKALTSFVKKYPQKRHFYKDMLFTIHYMNRDYVSALALVKNESNNKKYGCLLRISREIALDEIDKACKLEQSKELEMLRLRAIYDKNTTFITNVQHFNGSISNDYVLRDDLRNLNENNGRMDKTCADRKVNLIEMCRIAQKWDDDNLNIFCLRQIKENNDPCSFNAFLEKIKRTENVFYEKYVFCKRNSEWREAIEVLKEGIKTTRSSFLHYEHLFITDKLRSIPLAGSSSTIGLYFKIKSVISSAHANWQLEVLNVLKDALHRNGDFFIIYFDALLAVLSADCRNEMMDEKDSEQILKYFFNNLYFYISMGNWKGYYFVQIMDWSEDDILKKLFYGVELMRRDRTFYVVRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU64</accession>
    <name>L7JU64_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Telomerase catalytic subunit/reverse transcriptase TERT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU64"/>
    <dbReference type="STRING" id="72359.L7JU64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2499"/>
    <dbReference type="HOGENOM" id="CLU_1628216_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU64"/>
    <dbReference type="OMA" id="IFARMRI"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="163" mass="18669" checksum="C48AC2DDBE95D65D" modified="2013-03-06" version="1">MAQPLNLWMPLEITEVLNFVPMEEFLTNFSLQVDKQLCNNIFVRPPEKIPEIKDFTANNTVIKIINNAILKLLVSDSQNILSLGYARSVNDSSNNSLVCWHLNYATNVFKTKKWCELLRVLGDTLSMFLLTECGIIEKINDKYVLLAGNVKIFARMRIVQMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUC6</accession>
    <name>L7JUC6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2425"/>
    <dbReference type="HOGENOM" id="CLU_3385064_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUC6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="33" mass="3969" checksum="95475E4F6380D3B9" modified="2013-03-06" version="1">MNDFAMEGQKFSCFEGNFDFLLKDRCGFMRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUF2</accession>
    <name>L7JUF2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA helicase nonsense mRNA reducing factor (PNORF1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUF2"/>
    <dbReference type="STRING" id="72359.L7JUF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2679"/>
    <dbReference type="HOGENOM" id="CLU_2401231_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUF2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="93" mass="10569" checksum="B24794C4B64BF804" modified="2013-03-06" version="1">MPCSYCEAHSHLITCADCHQTFCNTFKGTTISHIIFHLKKNAHKRIMIDRPVVCELCGESNVFVLRRMDGMVCCGSCGMIGVMMERWLLMGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUN3</accession>
    <name>L7JUN3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2339"/>
    <dbReference type="HOGENOM" id="CLU_3260843_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUN3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="5063" checksum="4634355FD1A11B85" modified="2013-03-06" version="1">MQEEYVCISDNEVEDWSPDFLKKVLSIFKKDYGVYVDEMLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUQ9</accession>
    <name>L7JUQ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-3'-phosphate cyclase</fullName>
            <ecNumber evidence="3">6.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2602"/>
    <dbReference type="HOGENOM" id="CLU_900756_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUQ9"/>
    <dbReference type="OMA" id="PISCYIN"/>
    <dbReference type="OrthoDB" id="10396117at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="309" mass="35484" checksum="A5B001FDA80FF265" modified="2013-03-06" version="1">MTLKYPISCYINALLVILPFLKIKIVLIGATNLCEKNLVIEKKDVSEYSKRDDKKILEGEQKKASNKRGFKKNDNQSDTVKKHVQPPIESNDCFDVCFMKKCEDFDKSIDSLPIKLSVMKLFGAEIQHKILRRGFNSTKGKLELVNTQILERFESIELTENNCTRINTFIVSSHLSDFLPKSIRSIIKKNIPDARIDMDRNKDSGTVGLQVLMHCEYFYCETYRISRVEECCEKLMKYIFECILSENVFDDKLIDLVFVCMSLATGVSQVRIRGLESILCLVKAFYPVEVVEKDGITSIVGADFLNIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV15</accession>
    <name>L7JV15_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2516"/>
    <dbReference type="HOGENOM" id="CLU_1778767_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV15"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="17532" checksum="FD310250798E362B" modified="2013-03-06" version="1">MLEFSYKAQKQKIITISNNLLFDSDLLIFKPYTKEEILHIVRKKLECERISDEIIEYITLRERNDLRKIICACDELLLKNSEEISLKDIVVKKKRKESIHQEIIHDLKNSFRVKDEAFKNYLKRCKELNVDSLNRSDFTSVYENFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV33</accession>
    <name>L7JV33_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Elongator complex protein 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV33"/>
    <dbReference type="STRING" id="72359.L7JV33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1771"/>
    <dbReference type="HOGENOM" id="CLU_1157086_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV33"/>
    <dbReference type="OMA" id="PMEIAWR"/>
    <dbReference type="OrthoDB" id="2189612at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="240" mass="27304" checksum="0157694C2AA7E151" modified="2013-03-06" version="1">MRRPLGIGSTYKTNYLGIPLLDNTLSIEPGTSILIEHDPDTNNHHIFEKLFVAQSIADGKKVTVRSFPFCIPATVSRTEEQKYRPMEIAWRYAQRSRPETTEFDFLESCTNMQNVKFGDTIEIAERTCISGLCAPHDNLGCKELFEIKKKVICEHSVLLATCPTYICDVNVGLYFDIVLSLESNYAKENGYHGLLRIKKFTRKPDNLLYGYNISRYGVIMEQFSLAPDDEAPRLGCDVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV58</accession>
    <name>L7JV58_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5 6">Cytoplasmic vesicle</location>
            <location evidence="5 6">COPI-coated vesicle membrane</location>
            <topology evidence="5 6">Peripheral membrane protein</topology>
            <orientation evidence="5 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5 6">Golgi apparatus membrane</location>
            <topology evidence="5 6">Peripheral membrane protein</topology>
            <orientation evidence="5 6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV58"/>
    <dbReference type="STRING" id="72359.L7JV58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1896"/>
    <dbReference type="HOGENOM" id="CLU_664270_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV58"/>
    <dbReference type="OMA" id="DYEVEYC"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="414" mass="47175" checksum="1FFCC6DC3B9864AB" modified="2013-03-06" version="1">MIVCSFVQHNQNIIFRPVHKITQGAFETLLLTFNTTKKNDEGVIKTHSLNIYYATQDALTCAVIASKKCYENDMYAILKAVMGSITCFSSLEDVVGAFDDVVNEYTYFRLSSDNLRVIREMDSYEEKVHKMVAKNKEAENEKVMKEISEKVKLMGVKGAVNVQAGGPAVSYPSITVTDPLAGRVPEVHVDTFEKMKDEIRRACRATPSKKVQLLITERLSLVVDKEGNKKSGEITGDMTMYIKDERFKDISIEIRAPHPVKYSPNLQKDSAKKKVLKAKKSFPVKKCVALVKWTRNADTSDFTFNLWLTKNEGKLNVMMDYEKREDLQEIAFRFNTKGSELSNGHCREAVVWRSKHHQDNIEFVAERPVFPINVYFCGTRACMVGVEKIVMDDEAVDDYEVEYCYEGENVQIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV66</accession>
    <name>L7JV66_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2130"/>
    <dbReference type="HOGENOM" id="CLU_1476149_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV66"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="183" mass="21405" checksum="8E16A28D9F6432F4" modified="2013-03-06" version="1">MHIYRFMKIIDYLLRRDLRTLGNRLLGPLSWLVAKILNYFNRPQSYGEDKDFENDEAGSKMLDDKEMVKSYHFLKNFICSQIRALIELCSAGRKYICHVKAVKSAFDAPITALKDLNKNLIHNFNKLIRSRHDTNRYIVVGTSKKKFDAFDKTYGRLRQIIDSVVNFLRVHENKVGKKSSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV70</accession>
    <name>L7JV70_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2108"/>
    <dbReference type="HOGENOM" id="CLU_3178061_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV70"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="47" mass="5433" checksum="C3DA02591614257F" modified="2013-03-06" version="1" fragment="single">VLEDTMPGIKDALPINGQSESADRHSRLRYDTRAELKLLVLPKNVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV84</accession>
    <name>L7JV84_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1823"/>
    <dbReference type="HOGENOM" id="CLU_2910606_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV84"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7082" checksum="A824CCDBC26EB915" modified="2013-03-06" version="1" fragment="single">VKRSAASYKKVKNNLPHVIVKWLQKTGRKNASPENRTRTYCMASSNSTIRPVMPARAYYSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVB0</accession>
    <name>L7JVB0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2390"/>
    <dbReference type="HOGENOM" id="CLU_571329_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVB0"/>
    <dbReference type="OrthoDB" id="10601458at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="478" mass="55914" checksum="D9C8F21BA826D3AD" modified="2013-03-06" version="1">MLHRNKFVFDNEYKAKELNLTINKHGISKDEKEFCDEIEMLIDAEKNISDEDVRQDESCENRSAEEEKETAKMDGDLVENVVVVTTNCAKNDVNMVKRDINTDEKSDICHSVCDENHSFQRDTLCEEQVHVAEEKRKDVNGRKELLKSIDIKNIFDKKSFSSQLSSLVNRNKTVRGKTAIENTIDHENRSKNTENMNKPVEIADSTVLEKLLFDLPFAYNAVKINAMQQQHQLELQKKELTMIKAENTRIIDSFLKEFRKISEHIISGAHCDTPSKEMKNVQMPMNLMAETLETLKEAIKYKEEVVGLKDELCRIRGENEEIRREKQWLVDKLEQKEILDRVSTRIEMIGEEMIKANNNSADQRNILRKCMQTEKNCKKVYRDRTNQAIHHLNVLRTECDVLRTSLIDVKQLVDSIVELRRVSSSREIMQDEHVIITIKNEYESKIRCFQDEITRLKKTKRVKSMKPDNSDVWNVFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVC6</accession>
    <name>L7JVC6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Reverse transcriptase, LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993978">
        <property type="protein sequence ID" value="ELQ75250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVC6"/>
    <dbReference type="STRING" id="72359.L7JVC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1807"/>
    <dbReference type="HOGENOM" id="CLU_1176130_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVC6"/>
    <dbReference type="OMA" id="MHRIRAG"/>
    <dbReference type="OrthoDB" id="4488294at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="236" mass="28220" checksum="F6036C0E38F0B182" modified="2013-03-06" version="1">MVCAKPYTNKGSLKDKIEKELEEMKNKDYLRDSKSRWKNPVKPILKKDGRIRLCLNLMTLKEITNNEEEKISEIEEIFNKLHDAGYVTVLDMKERFFQIKIRERDKKNSISKSEVRNTNSIECRWDLKNFSFIFQQIMNHELRGWTDKNAQFYLDDVVIYAKTVEEHDKIFLKILDKFKKVKLKINLEKIQLKKKEINFMGQIVNGKTIRMLESRKMKIFDFNIPTNKKNCKGSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVD4</accession>
    <name>L7JVD4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993962">
        <property type="protein sequence ID" value="ELQ75448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1605"/>
    <dbReference type="HOGENOM" id="CLU_056990_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVD4"/>
    <dbReference type="OMA" id="FAEANFR"/>
    <dbReference type="OrthoDB" id="10411696at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="217" mass="25373" checksum="4C7ECFDC5C138749" modified="2013-03-06" version="1">MIINTITNILWHESLNHNLQCGLESLTLSGWGLEEKNIMMLRKFQNLRTLIVDSNHFKNEILENLPDQLETLEIIQKRNFYGANIKLVYFNSLALDKLKEHTNIRNLTFSGRFLRNTHIFACLPINLMVLKIMLSSRVDTLSPANILEKVTIKKLIIGLDEPNLSLRIYININPMKRQYYKTFDFLRNFIDFNSLDELVLETADGVVNIDKTTYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVH3</accession>
    <name>L7JVH3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2335"/>
    <dbReference type="HOGENOM" id="CLU_169844_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVH3"/>
    <dbReference type="OMA" id="NSCDFTQ"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="113" mass="12889" checksum="1A0E9D65FBE60AB6" modified="2013-03-06" version="1">MLPFTFSILKCNSCDFTQKLRLMPTKVHKITPASEFYREVDEDTLESLRKSFESVEGIYKLEDDTRMFLFGNVVDEGKIFCDGCGVYFPIEDGIVDFVNPVKVDGNEALTEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVI3</accession>
    <name>L7JVI3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2345"/>
    <dbReference type="HOGENOM" id="CLU_2623749_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVI3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="78" mass="9343" checksum="5AAED6318E020AF3" modified="2013-03-06" version="1">MTGVIEHNEREENGKGYATEIVKKFAAIDVIIDEFDTKIYEKINEIKEYRNNLEESIRKFKEKRNKKMREIYDIVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVU1</accession>
    <name>L7JVU1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small Conductance Mechanosensitive Ion Channel (MscS) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVU1"/>
    <dbReference type="STRING" id="72359.L7JVU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1619"/>
    <dbReference type="HOGENOM" id="CLU_531200_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVU1"/>
    <dbReference type="OMA" id="HMKVYMQ"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="513" mass="59653" checksum="63DA9D9161428DBD" modified="2013-03-06" version="1" fragment="single">MPRNDDRPGRGSRHNESEESEGENGPVSVNIRYPDESDEGAEREHESVSNEENAPSNEEVMPSRNRRSDGAYSIINRNEPNDEEREYLRRSRALHLENDASSHHQYDTPERRGLHDSDSTLTRDSDYNALGKEPSSKMTHFFRRVFVFFDRLLEIDFIYFFLGSVIILLTALCIPADYTYTCFQKEEGSDVLKEWPLKLRPVFFGIAIVLFIMGCIASVIYYVAQILLKYLGDQDGWFATFCSLNCHIAMLIILITLLITFMYKRMANLQFAKGTNLDISHVLSTLLFANFLLTLKTFILKKVSLTFNYSTHLNRVRLILLDEYFKNFLKGLRGLDSIGDAKNDSYWKNFLPYGKHKSQEKAVQVFERLFVDDLKKKETENVLLTEFSKIHARPIDPFKNDQASKEFWLKRSKKIYAGSNTSNSFNTINDFAGLFASRELFERFCVLLKIKPRDTYNEKMIYALLERKDKEHCFLSRSFEQNNAALDRVGIHAFCGDCVRCSEHLFRYFSEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVV7</accession>
    <name>L7JVV7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVV7"/>
    <dbReference type="STRING" id="72359.L7JVV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1424"/>
    <dbReference type="HOGENOM" id="CLU_040462_3_1_1"/>
    <dbReference type="InParanoid" id="L7JVV7"/>
    <dbReference type="OMA" id="QIILEFF"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="255" mass="28390" checksum="3AEB98B358D32DBF" modified="2013-03-06" version="1">MVCNTALLLLSAFVFVFTLLFSFSYALFKNTKLSLYSKCFSGGVLLSTIIFHIFPDVYTRENCFIAPFSAGISFLILFSIDKLYLQYRESHGNTFTKLNNRLQALVFICALSVHSFMEGLGTSVKTGTSLVWYAIGLLGHKWIEAFVVSVTMHTSGFSQLETILLLVFYSVLTPLGTVLGMIMMSSARFPSQTAELLNGVACGSFFYIGFIEMLNSEFESHTLLRKRDQRKIAAVFAGFFTMTSIALALSSMVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVY1</accession>
    <name>L7JVY1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin B, kinase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVY1"/>
    <dbReference type="FunCoup" id="L7JVY1">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1903"/>
    <dbReference type="HOGENOM" id="CLU_020695_2_4_1"/>
    <dbReference type="InParanoid" id="L7JVY1"/>
    <dbReference type="OMA" id="WRMRTIL"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="182"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="273"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="277"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="397" mass="46267" checksum="627AC590F75DB18B" modified="2013-03-06" version="1">MRRTVLRNITNKDEGRKEDGTREEQKWKCTDDERANITCMADCGKYGQEKDRRCDFVDTTSPEINSSCKHSGALPGKTFANDGIKAADSGKKHAEPLAEKDVNAPEKKILKEESRVGQSTLTDEERSFYEIMEMDAQSDITMEYGYAEHFFARFKDQKVLINHDYMVYQQELTWRMRTILVDWLIDVHWQLGLHPETLFLTVDLIDRFLSLRTVSKNKLQLVGVTALMVAAKYEEVECPLFSTFRMLINCDTSDLMNAERYLLMTLDFNLNYLSPLCFVRRLSIVNNYEVKTRVLAKYILELMLLNEQFIIYNAHIKACAAFYTARKILEMDNFSNLFFMLACTDKKTIKGCVNDILVMLAKPIRYDSVKRKYGVDRMMRVSAFVEEFRVKHLSKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVZ9</accession>
    <name>L7JVZ9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_2121</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVZ9"/>
    <dbReference type="STRING" id="72359.L7JVZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2121"/>
    <dbReference type="HOGENOM" id="CLU_728026_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVZ9"/>
    <dbReference type="OMA" id="RIFKWDE"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ74932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="421" mass="48691" checksum="26BD53D42B99B9F8" modified="2013-03-06" version="1">MADKLCHYCILYELQFEICSYIKTKQMFYFFNKGMHTYYSMRTVTLILLTQAVWCVFVAQNEDQNGNNTPFFGINLKGLFNYFLGGLKNLARIGRIFKWDEVFYKEPQNELENFDITDKEKLLLYKLALLCQQTYNIEDYYDSSLKKNYEREVKRYKIANGISNTSNLRRKAGDFEVFYTKTEFIRNYLKGIVFTVDHTTVIAYKGTSPSLLGYGNGSTSTSDRIFDNIAFDCNLSPEKVKRLFYLQDARQVYLDVKRRFPNNKIILTGHSMGAAIASAIGYIYNEYVIAFGTPGDHQIIKRLHPREPKAPDRKKASSVIDNLFLKIGNDTVHVSDCRDVIYRGACNGRVDICKISGYDIKTKCHVGVALCFDNEGTLGLFKHTIYSVVEKLKREKLPFYKIDESGCKKTECENEMNEIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW54</accession>
    <name>L7JW54_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1355"/>
    <dbReference type="HOGENOM" id="CLU_728028_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW54"/>
    <dbReference type="OrthoDB" id="2196332at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="398" mass="46346" checksum="09FF434FC6CAD9DB" modified="2013-03-06" version="1" fragment="single">VHFEIFYYLGVIMTISSDIVVVYEEKTGNVQKRERKEKRKEVPVKDENINIEHGECNCYRCLNSGSDIEIKQLSDNHEQGKRLRKSSPIISKEEATNLSISLLDLPFKIGQYNEEKNLQYLNKFKTGEINKINDKERGDENIVTQENAETLNNNIFGNDVGINTLDHVFIPYHFLIPDTLKKYRKYLQLNFDFHGGNSIIIKNLESQTEESFPVLNCITELKSLRNYKTERLIFLHNLKNLEKQIKKKENSNFLSSLENRTQYQSENEFSAIKQELFSFQMVNKVNFIHIENANDILIALKNIIRYKEAVFVPKVKKCKDKNKFLMNLLEFIPGVSKNVSRAIVNTYKSLNDIVKCENFCDIEVFNDEGSSFRLVGKRQSDLIRKVFDKASLLKGDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW90</accession>
    <name>L7JW90_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2065"/>
    <dbReference type="HOGENOM" id="CLU_3130051_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW90"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="6098" checksum="284A81438FF9DA00" modified="2013-03-06" version="1" fragment="single">VLGNLFYREFEFNWYKKMIIGDSYLEGGKRGNSYRRKKGHLKVQLVDEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWD1</accession>
    <name>L7JWD1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zuotin, molecular chaperone (DnaJ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWD1"/>
    <dbReference type="STRING" id="72359.L7JWD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1386"/>
    <dbReference type="HOGENOM" id="CLU_082159_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWD1"/>
    <dbReference type="OMA" id="CKDEDYQ"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAMYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="293" mass="35267" checksum="8A666D985780E095" modified="2013-03-06" version="1">MKITVHEDHVRILKERAEQQRKDTDILAKYVPAQLTHILAIDLYFLLNVQEYRRLPIPPNVLFLRYRERIVRYHPNYHDDRVFIAIRNGYEILKSTFWKKKYDDYFVEDIPVEDKNYGSTFYEFFGKYFENMRVFAKGDAPMLGDPETPPERVEMFYAFWKNFESTRSFDFIAYHPGYETMNDFERTDHDAKFRKEKKTLFNQHVIEVRNSAAICQRNDPRIKREKVFVDPSLVCNGWSENDVVLLKRLTKKYRAGNTVDWKRVVKEFKMENGARKSMKDLLVKNTQLERVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWM2</accession>
    <name>L7JWM2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA uracil-5-methyltransferase, tRNA-modifying enzyme</fullName>
            <ecNumber evidence="6">2.1.1.35</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWM2"/>
    <dbReference type="STRING" id="72359.L7JWM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1357"/>
    <dbReference type="HOGENOM" id="CLU_024084_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWM2"/>
    <dbReference type="OMA" id="DELFYIS"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="490" mass="55763" checksum="9AE85ED57CC6337A" modified="2013-03-06" version="1">MKLSNLNEFLEKNALHPINELVSPVNTQRNNFEFAFGFNAQGRPCVGFRGQSFKGNKNLCYECTNVEFIGELKQRIEAVDEMVKNCEWMVYDREKGTGYLRMMKVRVVNGNEHLVLVDIDGSNESDRNVQECSGIVDKTNHFSDHHARDKTDQAIVNYEHFYMLFKSCIDGHLQQLYNFLMNLPFTNVSLVFNRTKFEGISPGPSLIIKGASHLFQHIHNLKFKISFFTFFQTNIEMLIAIVEQIKAVKKNNPYLLDLCCGSLVLGMMLCSDYKEVIGVENNLECVKDFNVNRDVNEVKNCRIMGVDVNTVSVREIVRSILKEKTASRVSDGLNEKELNGNGEGGMISSQNVSNEENQQSTEKCHIGGEIITNDRFAVNKATDNTFATSYTTARLENETINREENITVILDPPRAGVNKRLIKKLRECTAIDELFYISCDFNQSIGNIKDLTRKESNAYKSGFVVVGTYAFDMFAGNKKVEVLYHLRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWN3</accession>
    <name>L7JWN3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993954">
        <property type="protein sequence ID" value="ELQ75471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1575"/>
    <dbReference type="HOGENOM" id="CLU_1760072_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWN3"/>
    <dbReference type="OrthoDB" id="2195775at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="16641" checksum="E0CD551F2DC75FCE" modified="2013-03-06" version="1">MPIYAVLCAMFMRYALSRTINELEYFTGKDIYIKLAGFDGIRLAYSKIDNSFKFVNSNTNPTTFAYDDRARLAMNGNKFELFIGGVQACQQKNLIVRCDSSDPKKSSLFKISKDQFGFELSNGDMCITKDMDAKGEHEEVRAAAGPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWP9</accession>
    <name>L7JWP9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Ribosomal protein L24e protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993905">
        <property type="protein sequence ID" value="ELQ75908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWP9"/>
    <dbReference type="STRING" id="72359.L7JWP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1131"/>
    <dbReference type="HOGENOM" id="CLU_150146_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWP9"/>
    <dbReference type="OMA" id="QHDGRAQ"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="129" mass="14553" checksum="C06AFE563BE310BB" modified="2013-03-06" version="1">MPFQMVTQGKCVFSGQDVPKAKGTYRVQHDGRAQLTRTTKASSYLKRSIKPQKVLWTLGARFFHKKGGAVHKKERERIVPPKIVRGFPCLPKKAVEEVKKGVVGKKEKVEGVFQRRGKIGKNVNVGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWU9</accession>
    <name>L7JWU9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993983">
        <property type="protein sequence ID" value="ELQ75192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1869"/>
    <dbReference type="HOGENOM" id="CLU_2160179_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWU9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="111" mass="13134" checksum="93E37AB544BE0194" modified="2013-03-06" version="1">MLFSTIENICGFPYPSRMNKEIYELLDKLTIELANRKTPTDLQEALTYEATSLYVYYTLETMKNKLENKYDKDVIEKVQGLEKYFNEHIEPCTNESLILEELYGKHDHKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWW4</accession>
    <name>L7JWW4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional repressor EED/ESC/FIE, required for transcriptional silencing, WD repeat superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWW4"/>
    <dbReference type="STRING" id="72359.L7JWW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1484"/>
    <dbReference type="HOGENOM" id="CLU_032683_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWW4"/>
    <dbReference type="OMA" id="HKAYINC"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="340" mass="38805" checksum="0E08130766F0D9AA" modified="2013-03-06" version="1">MEFVKRTVLSSTFVSKICLHRRKKIFCVYGRRNAYIMNHDLEQLQKYLDEDDKEEFLSCTFYDLKDKTLLVLAGERGILKIIDLCTGSFYMALKGHGGPIIDMLHKEVRPNIVFSASSDTTIRMWDLQRACTLVIFGGLAGHEDVVLSIDISVDGNYLVSSGTDNSIKVWSIPNITSEVVIKDRAFTPGKYHFGNSEFNYTDIPVKTNFPIFNSQVLHKAYINCVKFFGNVIISKNISKRLSIVKFKGTYEIYKNSVDSDVIILKEYKFKEKLIHRFTIFGTTLVVFDEKGNCYTINLSLCNEPVLAAQIDNVKDASLINNLLFIVSNNNEVHCYTINKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX36</accession>
    <name>L7JX36_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993889">
        <property type="protein sequence ID" value="ELQ75994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1034"/>
    <dbReference type="HOGENOM" id="CLU_987605_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX36"/>
    <dbReference type="OrthoDB" id="10310821at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="282" mass="33649" checksum="131FA83D7A79E25A" modified="2013-03-06" version="1">MGLKYIFVFTNEQGTNEVDFLLFENPGDAEMSYLLNSHEMVNSKLSLSHETVKYVYYEKTEMNYRTIYDNVHYHSHIAGIRRIIYRIYHDVIRENADVRFEVVHVPFTMLLYQKVMKCLQQDVIPDINTKEACTLLTHFALFDEYVKESIAYVICVYLLANTELFHDIRDYRENPDDNQYALSTRRLYQLIFSDSKASIQFRKAVKSYARFSLFDKDGNSAQIYNASDNRRFHRYNIDICNFSLDFLLDRLDIDFRWLEKNMKILDEKFNVGTRDSPYSVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX81</accession>
    <name>L7JX81_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Replication factor A protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993904">
        <property type="protein sequence ID" value="ELQ75915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1123"/>
    <dbReference type="HOGENOM" id="CLU_2374264_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX81"/>
    <dbReference type="OMA" id="LHKYTKN"/>
    <dbReference type="OrthoDB" id="2186234at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="11061" checksum="129AF05139FFCA92" modified="2013-03-06" version="1">MYITSNSAIVPNTDIKVVGRVTKVDSPFIYLQYNGNTVKIKYNNLHKYTKNTLIVTGTYNDGVLEEKYVDELDDDFDDKLFYRVVSAMEKYEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX83</accession>
    <name>L7JX83_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993887">
        <property type="protein sequence ID" value="ELQ76039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0990"/>
    <dbReference type="HOGENOM" id="CLU_2279415_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX83"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="102" mass="11984" checksum="9CB6B78DD32B140C" modified="2013-03-06" version="1">MSNVHVEDKLVFNDEIEICILEQMKFEKKAEMWFKPDVVNFFIQNSKVSVDKVVLEDNNETIKPKAFHADFIEPNNENFSICKLYIEKDQLYGNAVVLNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXB2</accession>
    <name>L7JXB2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993874">
        <property type="protein sequence ID" value="ELQ76108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0922"/>
    <dbReference type="HOGENOM" id="CLU_427103_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXB2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="641" mass="73060" checksum="154FBFB2E7CD419B" modified="2013-03-06" version="1">MRGIDIIILLTINCLQIKCSEDEVEIKERLHMFVVLIKDIREKWFECNFSFDNLEVEGKNRCFSGAYHLINANKEYSCSLSNSPLSLEEYNLPSQQHSSKFAGSLKAYIDIVEFCLLNAIPSSQIKFIQAGLNVIVDLTIFIDRISEVHHKRERFKTLYYSQKRVIMENMKPIIKFLSDEAREMLWIKYKIGAPRLLEETSICNKEDESNCTETDFSMIDYSSTPQSSSPNDSTTLSYQHHDRDCDENIIPSKLSDHNACLCSTFQEIGPEFVQNAFPGGIIDRYRAQQVFQALSSIITNESTKTPSMSSNISTIYQKAYHNCDNDRTINTYNDMAPGYTDRREKKAQNDDSLYISSFMENEFVEYDGNDGWTVPKRKNSRIRTYGKKVKNIFKSSFSRARNNTRNIVPEVTSNHISTNTLRVLNSDTIDVSIDNCSSTNESAPNYTSNDNCSSNIESASSYISGDSLYSISDNVSDCIPNDSLSTENIYDDTTITTIRPTLDRTFELISNHNLDYCLKTCDHGDTTNHEVSDIQTEENITKSFEHQFDYKSKEAAERSPVTSHSSIYDIDKDTPDPYIESKTKYHTITSSKTIAKTDNETYKDQNKTKDEKSCKTPSMVNCCLIGLIIVSVCLFVVINNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXH8</accession>
    <name>L7JXH8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_0895</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0895"/>
    <dbReference type="HOGENOM" id="CLU_013159_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXH8"/>
    <dbReference type="OMA" id="NTRWELS"/>
    <dbReference type="OrthoDB" id="2195965at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013152966" description="SMP-LTD domain-containing protein" evidence="11">
        <location>
            <begin position="16"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="59"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ76134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="993" mass="114886" checksum="6531EED86121CF7F" modified="2013-03-06" version="1">MFLLILLSYILGLAASPFIIEQLLRNLTKKRKPIAISQSIGKRSISANQSGMIDDSQHVCTDVAWFNLLMQRLWVELSVSYAHKDRMRKSLMRRMASMHTKRILSDLVIEDIKISPEAPMIGNVRVVDDEQCAMLMKKMKKRKNARRKIDELIENNLSVLKDELNRYFDEGEGRADRASTYGAVREDGEVLSDSFPETNGTKDETLVFDRVHSILDIAYNGEMKLFLTVNLLRKLKVNAVCTLGKFSGKVLCNIPSISSNTRWELSFLSDPQFTITVKAFLSTTTSESIYFEGVVSSILKKVIKYGLMSKMVFPSFYQFPLPMVSPSLRFVNHSVQVFNNADYQSWCKDVANKIRLYETMNYKTIKRKMNHALLRNSSYINNDTDRIYLAELVFNEEAMKNVLARRYGDGSRKDGVAGDDKEGRNGRESNDNGQMYLIETQKKEWNRFNHTRSNVWQEAKNENGGEKESLDSDSKTGDGNGCDTKNAFEGENGSCKYEKTGVRGKTGKLDEMVKMTVKECLAQDKKYQTLRNTMRISDEDVLLMMDFYELDVFSAMYKNFLYFREIEIISGRVSIIRLYFQNESYDYVRILEDDAVFFQRNDQREPEFMAVHVYDRRVHLYYYLTNRSFFINQSDVQKMYASFFEKRTLSARNTSTESIDQPNVDELVQRMDDIREINTNYVEKSLLLEMKKNELMDVLGDVCLRLKLFGLCAPIVTARQISTNLKMYLVGHKEKECKLLSYSDQKVLIDTILNSESSTVIYNVENFETARHISIKYTGDLEAHLHDYFLPALMFRIRMLSYSKDKSVFESVYNKSLEYRFPVETSSIIFLELHSEITDEFYVTITADRRKIVNNLRVITTSNAKFLFSLKGKNKIKIGIRPKALRNRKLYVNLAQHPVLVVKNELVIECVTLLAGNTSKNIKFDAESDNRIIWDLEDGDDVKYLLSNDRHSSFIGRFGVLYCQKQRYNLQIINEGVKQRNIKLLVGVTPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXJ6</accession>
    <name>L7JXJ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyadenylate-binding protein (RRM superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0860"/>
    <dbReference type="HOGENOM" id="CLU_2225034_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXJ6"/>
    <dbReference type="OrthoDB" id="2186698at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="106" mass="12014" checksum="55AB26EDEDD017B0" modified="2013-03-06" version="1">MHAEVGSVAASTSPRHVCISQGIGSLHEQELIEMLGNCDLIWPKDAKNAKKPYVFAQFQTEDEKKEAIDKLNGKKVDEENTLKLSPAYSQRFTQRPPTDRRRRFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXM7</accession>
    <name>L7JXM7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0814"/>
    <dbReference type="HOGENOM" id="CLU_3207933_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXM7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="45" mass="5278" checksum="1FFCBCD3D2EC7E29" modified="2013-03-06" version="1">MNDMPGRKWNYPADMCMGTNEFLFTRFFNGDFSIRGDSNGLNFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXP5</accession>
    <name>L7JXP5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Like-Sm ribonucleoprotein (LSM) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993919">
        <property type="protein sequence ID" value="ELQ75826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1219"/>
    <dbReference type="HOGENOM" id="CLU_187872_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXP5"/>
    <dbReference type="OMA" id="CIYRGKA"/>
    <dbReference type="OrthoDB" id="2188491at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="69" mass="7867" checksum="99F4680EB572B5A4" modified="2013-03-06" version="1">MYDIYKSFIRKRIKIKLNDNSSIEGDLISIDGYLNLALQHVLLYEEGIGEPFVFRSCLVKGSNVECIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXQ4</accession>
    <name>L7JXQ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Prokaryotic chromosome segregation/condensation protein ScpA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0794"/>
    <dbReference type="HOGENOM" id="CLU_1038954_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXQ4"/>
    <dbReference type="OMA" id="CILRMIT"/>
    <dbReference type="OrthoDB" id="10461102at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="268" mass="31307" checksum="E7FA31F062E651D8" modified="2013-03-06" version="1">MKLDIIKGSVYKRTIKEDDIGEFIEFFPTYKDELITRVYFLHILSKTTLKFSKILNTEIKRIINNVDGNVLSEKRNIRSKINRKVFDAELEAANNLSVNNSFAEPDCCDIDFDNRNTGDTHIISNDEREIIVYPVYSNRLFKRVKVNLRIFPLKTFSIIQMITDKIIRTLGNIKSFNLIEEIRDNDTCDFVENCDSFEGTHLFSSSLLNSNMMNELEAMNIICFNEKMFGIDREHKVAAFCKLLELLVQNKVTVEQIDCYTNIYVYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXQ8</accession>
    <name>L7JXQ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0838"/>
    <dbReference type="HOGENOM" id="CLU_744328_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXQ8"/>
    <dbReference type="OMA" id="ININMQN"/>
    <dbReference type="OrthoDB" id="10553709at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="407" mass="46294" checksum="AE862F220A16D730" modified="2013-03-06" version="1">MVMSDSSDIEIVSTKRKDGDVEVVNFGDRKGRVGRKGTALTINLRGRGKRRRSTANDRELDKTGCVEGKKEFKSKNASNKNENNNKDEKDKKQEVNSKEKFNSKDKNINKEVRQRPHVNETVSEQKRTMNSHTDASNSKWRNDSEATENGKMKSNEFITNKTENLQKKNEEDRKIVEQSKRFETSTGVTQEETAKNADLLHSTDQSININMQNTLQAHVQYTPVDHNSYLTQKHLINSKQHTPALTASTSHQEAAILTAPSDHITFTVQHDTNTSTFTLPPSSTLRPVYDQLCKNTPNKIQFGQNFVSRFSSLHVLNIKNGDVLRIVNPTKRCIDDRNESVATRKMVRVNYAVNKSVEIELLEGDDLNALVARVNAVLNDEYRYFVMNGMRCVKNVFEDGDVVDVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXT1</accession>
    <name>L7JXT1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993912">
        <property type="protein sequence ID" value="ELQ75861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1175"/>
    <dbReference type="HOGENOM" id="CLU_2225035_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXT1"/>
    <dbReference type="OrthoDB" id="10509931at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="106" mass="12416" checksum="F8E7F49380D1FAC1" modified="2013-03-06" version="1">MNSLPATHVFNTCTCHEMNSLPATHVCTDPYATIQRNRALLNRTLMIENIMADRKQRYIKSVHEHFDSLVGQYHDALQGWEVERCIGVKKEIFKVWTMIRKWNRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXV6</accession>
    <name>L7JXV6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphatidylserine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_0879</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993869">
        <property type="protein sequence ID" value="ELQ76145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXV6"/>
    <dbReference type="STRING" id="72359.L7JXV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0879"/>
    <dbReference type="HOGENOM" id="CLU_037661_4_1_1"/>
    <dbReference type="InParanoid" id="L7JXV6"/>
    <dbReference type="OMA" id="QHVLPNF"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ76145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="405" mass="47599" checksum="BE82B2BA7AC71505" modified="2013-03-06" version="1">MSILRKTVKTDRKLIAFFSKPHTLSLLVLLISVLIYHAFNMPSNPYKSALFSSFLVFNVIGILQFTDSIFKRPIAILWRCVKASSIYYLIILIILFYFEKEDIRKALSYFYTELNVPLPQRSYATHCEINMRNIINQMDVFVPLHIFGWFFKTLLLRDRTICWILSVLFEFAEYSLQHQLDNFAECWWDHWILDVLTCNFLGIEMGMLFIQKMRIKRYEFVKLCNSLKRYVAIITLIVFILAAELNVFYLKFLLYIPTEHNINLYRLCIFVPGGALAVREAFEYYATSEKIVRGQLWLSMAIVCVETMVVIKYSRGVFTRPFPQAVVIGWCAGICAIVLGGVFFFLKKVTLVIKRNFCQNIFVITAFRQCFLVIFLIPIDMMVNHRYGRFSHHVIQFISKNSIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXW6</accession>
    <name>L7JXW6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-6-phosphate 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0770"/>
    <dbReference type="HOGENOM" id="CLU_1866525_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXW6"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="137" mass="15663" checksum="7D6E62C46CBE0399" modified="2013-03-06" version="1">MTIFVNTGKIAIFRTPPDFVMDKIFIIFGASGNLSKVKLLPSILKEKLYKDCEIVLYSRNVDDDVLQAQVKEVNDKNLRIVQGQYTDTEKIAELINGKKLVIFYLCIPSHQHLTIIQSLDNLNREVVVALEKPFLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY35</accession>
    <name>L7JY35_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993853">
        <property type="protein sequence ID" value="ELQ76383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY35"/>
    <dbReference type="FunCoup" id="L7JY35">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0639"/>
    <dbReference type="HOGENOM" id="CLU_000134_46_3_1"/>
    <dbReference type="InParanoid" id="L7JY35"/>
    <dbReference type="OMA" id="RSACYAK"/>
    <dbReference type="OrthoDB" id="2187829at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="179" mass="20583" checksum="5F4412B117BF6636" modified="2013-03-06" version="1">MEMAESLRKEGTELFKKGDYEGALNKYTEAIEKDPQNKVLYSNRSACYAKLNKNEEGIVDAEKAVELDPNYAKAYSRLGSFYYYTDPVKSAHYYEKALESDSSNKEYQKMVSDLKKRTQNRNDLNMAGKNGNMDIESLFNNPELMNYAKELLKNKSPEEINKMKEMFGNMMNGKQNGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY82</accession>
    <name>L7JY82_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0624"/>
    <dbReference type="HOGENOM" id="CLU_2607711_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY82"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9185" checksum="7D9E9336635E863A" modified="2013-03-06" version="1">MVGMKNCQKISRRDTPIIENKNLSSIINGLAEIRCVIIQAFCRRSFDSNIVKIGVSEANMIYHVKQYFDEHLVIQCRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY84</accession>
    <name>L7JY84_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1354"/>
    <dbReference type="HOGENOM" id="CLU_170542_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY84"/>
    <dbReference type="OrthoDB" id="2197496at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9346" checksum="73BA5D735CC4E249" modified="2013-03-06" version="1" fragment="single">VPIIVFDFCGGILKYTMLIELNVTYYFVLDYESVKDEVNNTIDGDDIVFLLVDWRLNDNMRDFMERKVKKNVFILVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYD0</accession>
    <name>L7JYD0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0505"/>
    <dbReference type="HOGENOM" id="CLU_1023777_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYD0"/>
    <dbReference type="OMA" id="HGNYRDK"/>
    <dbReference type="OrthoDB" id="2190805at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="271" mass="31644" checksum="64A0325596989B38" modified="2013-03-06" version="1">MTVNEKENFNFLEFKSIEDPIKSMEVLKTTFLKLKQLTRDELTMLFADTDFFVFLEDALVMMKNDREFVEFVCGLEIEDSIVEKHGMKEFMNKCADIRRDMECSTTDAANPPKRKRKTKRVSFSLEKNMTKLYLVEKSEMKHGNYRDKDREEAAILKNVPWIVPIRLRPCAEFKRRSEEVNVQKIRETTTVKITNLESENFVPSDGSAKKEKVPATSKPVEICIFDSNVSNILPKLDYAKIVCGDEKVRYTVADILNDEKVLEHFMKKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYE0</accession>
    <name>L7JYE0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYE0"/>
    <dbReference type="STRING" id="72359.L7JYE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1275"/>
    <dbReference type="HOGENOM" id="CLU_001485_2_11_1"/>
    <dbReference type="InParanoid" id="L7JYE0"/>
    <dbReference type="OMA" id="MPINVYL"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1004">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="98"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="683" mass="77136" checksum="1C796CD3B0EAD127" modified="2013-03-06" version="1">MSVDERHGMNEENKRRKMCINGNNEGGDNNEGGNSKDFNRIGGKDCSNDEGGNSKDCNTTTPNTTISNTTPNTNPMPNTTTNPMPNTTTSPMPTNPMPINVYLRIKPSDTAQYAVSNGTLTYNNATYTFTKIFTKSSQSQLFDQIGKQTVINTIKGYNTTIFAYGQTGSGKTYTIKGDTHRPGLVPRILNYIFECNVADEVALSMLEIYNEKLRDLLCDEGVLCIREGLDGTYVGNLGKVVVRDYEMAMDVYERGSVRRRVGWMGMNRESSRSHCVLMVYFRGGEGVLVKESRINIVDLAGSERIRDGEWGRDKGSRGERFNNGGFNNEGFNNERLNNERFNNDYNGRESNNYSYNNPYKDEHHAREDHTNYAILNDRSAATIKETGNINKSLLSLREVIKKLGNNQNDHINYRDSKLTFLLKDSLGGNSNLTIIGTLNLTYKTESIHTLRFLQRAKHIKNTPTLSVGVKGDVEDIKRELTRVYARNKELEMRLREYEVGGTVRRVSGRYGDDIRWVRGEIVKVGGMVRGLIGDVERIVMGWFDRNRGVIRRMDEVLRRGSKLGGIIGDNNNDNNDGFDNNIDNRNDDTNDNIDNNNDNRNDDYIDNRNDGCDNNTNGNNNRNDDTNGNTTNNNNNINNINDNINNINKQNEKENVINNKIRVKNTNCDEASVKNVNSNTTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYE7</accession>
    <name>L7JYE7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine protein kinase</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
            <ecNumber evidence="10">2.7.11.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EC" id="2.7.11.17" evidence="10"/>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYE7"/>
    <dbReference type="FunCoup" id="L7JYE7">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0521"/>
    <dbReference type="HOGENOM" id="CLU_000288_59_11_1"/>
    <dbReference type="InParanoid" id="L7JYE7"/>
    <dbReference type="OMA" id="IRPTIKM"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="95"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="592" mass="67812" checksum="0775F940D4DA1AB1" modified="2013-03-06" version="1">MCTRTTMRANSSSSLDEIYEDTNSENIKTENGLDTEHEDAEQQRLSGYKGECVDEFCSGKCQSADRQSNGDSTVLDKHGYVCADRMLNERRIKEYTLLRTLGKGSFSKVKLAASPDGQHVAIKIIPRNLRYNSINKESRCKREERIYREAIITALVCHPHIIKLRAFFYNDLHFYMVYEYVSGRSLLNCIRENGVLDEQLARKFFTQIVDAVNFMHSNAIVHRDLKIENILIDKGGNIKIIDFGLSNFYDSKQFLGTFCGSLQFAAPELLRGRVYTGPEVDMWSLGVILYVMVVGTLPFDDKDVSILHSKIKKGRFAFRREVSASARKLIGGLIESDAKKRYRMRDVLKSDWLNERSPSQTKHPQNEQQYAHTHPYMNPTVTSMTAKMRAPNSFNSAFIDVLRKVGGKAFENTGTDMQACADDVSMLSCIRPTIKMYRLLESHFSNKELPRFVVTGSRKESLHRLVSIMHNDCPRLNLIPTTNIVQPKVKVQNTLLKGIFTGISCNNVDNSERLGKTIHRFFKLHRIKTMADEDHYSCLLKMEGMYVEFSLAFYFNVVIKKHYVCVRKRHGSRTLFDTVVVWLKEVLGSTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYF9</accession>
    <name>L7JYF9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0495"/>
    <dbReference type="HOGENOM" id="CLU_245699_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYF9"/>
    <dbReference type="OrthoDB" id="2191600at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1566" mass="179403" checksum="22D285E5F0724BB4" modified="2013-03-06" version="1" fragment="single">VXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRDKKDATTIDSFSNTIRDEKDATTIDSFSNTIRGEKDVIAEKMVLPDQGIVIEDLKVKIRKIENGLNLKVNISDVLNSVLLHKILILKEYYVLPQLGIIGTAMRLNYVIYIARIRNDLPYDLPIKTNITNLCVENDTMKLDVEYENIYTRLNIKTTYDVVNTLKVSTNNIVIKNEVQDFISYQKIVQTLLDEFNTNFTSGRNTQINLIVKDSELYVNRSRPQDTGTNHFVETIPLLMVSIEKLIFFSPTTGSLKFAGYVFNPRILEYELLFEPANVVVAMLGNKISVKCTDLRLSIAKETFQTFSFDHKDCIVQLENIMSSLNVLLRAGQHEKYELDAVPEYDEHDLPAQDAVTRARVIKNAEESENQRCTDEGTGLGLTKRKEMIKRSFNRDGISDPKVSDVTVGPLTGAIVHKRFYSKKLDLTIGDEKITVDLTEEEKLHVHNAFVFTKIHEFNRYIRVYNHIYFKNCLPYELCLLLGDDELQEEELLLKKDLSFNSPHMYLRIKMGNKISADSFMFQKGVYKADVDNVTLFLDEKSILIEKKIINMLSYVENVSGNLVYYVFFLPNSYIVNKTSKSLNICLEGSFFARNIVIEPEEIVAADCWRFKERIGIKGPSDEFVSVSNAFLNRNQSTQVQVSDERTRHDFIISHKSFAEHSSILLTRKKLSVRILRNVFKVFNLYVLNFRFKVTNSINEKVYIDDERVMQGTTERDITRGTVLINNRLRIFDFNVLNVLKELEHKYLLSMETKNVVIDVGTKLDVIDQDNVADPHEIQFDQKYVEIKYSYVVENRTGIELTVNDTFFGNDEHKPIEMHKKNMLRINSTDVNMIVCPYFQIGDNFYTVITKIREKQKIMRLETSESPIEIHNNTETVVCVNRKYFLNPGDTLNYVYDSYKDSKIEFETNIEGKLVRLRRKYGRAVCTDNLKVTSMNRGAKEYIYLGTTPTNVHFEDVFVVLINSLTVSLFENNCEFVNLYFRDLEAVKQIDTLKNLFTYAFSIKGMQIDNQSHSPAFPIILSPVYPTFYYHNSAASADDGHFLIYKCEINGAFFNQDESVPAKGTLSFNYIIFAMHEFELSIEEEVLTRLFMWMPKKKGDTSLFCTLLHIHPINLRLNLLISKKKHFIHKLIGFLVSNLSEVRLSFTTLIFSQFEYNNDLIINAYKMQMLSQIFNLIGGLDLLGNLSSLVEELSLGVHDLFYEPYVGLKHDDLFMFTKGILKGGKNFVTYCISGLTSTVGKMGRSISRTSSNKRLLFYDELEVDVTKDLIENVVDGLSGIITKPVKGAKKGVKGFLKGVGSGLKGALMKPIAGISEFAANISDNIKTNMNGADLRRIQYPRYKLEKYNLDLCQAYFLFEIYKDKDMQPIDSNSPGHFKAKNEKFVGGGRGKVYDMKVHIVVTDQRLLMISRQANLHINSFDVVTGGIKVKDWIVELNDEVMNYVKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYG2</accession>
    <name>L7JYG2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1233"/>
    <dbReference type="HOGENOM" id="CLU_3020137_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYG2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6618" checksum="505E45839F1B2C9C" modified="2013-03-06" version="1" fragment="single">VRLRRRLRLSKRSYNFIKTGFENVFTCGLVTVLDCTLQFDKDSLFDVGMRRTCLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYK1</accession>
    <name>L7JYK1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYK1"/>
    <dbReference type="FunCoup" id="L7JYK1">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0620"/>
    <dbReference type="HOGENOM" id="CLU_140672_1_1_1"/>
    <dbReference type="InParanoid" id="L7JYK1"/>
    <dbReference type="OMA" id="WGINRGH"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="93" mass="10842" checksum="0E14B0D3E79E4170" modified="2013-03-06" version="1">MILNKKARALHHKTVKTPFPRKSKKFDLSKSQKAFFARDIVKEIVGKAPYELCAMDMIRKSQDKKVKKYLRKRLGSLKCAKKKIDALTNEIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYN6</accession>
    <name>L7JYN6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_0576</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYN6"/>
    <dbReference type="FunCoup" id="L7JYN6">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0576"/>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="InParanoid" id="L7JYN6"/>
    <dbReference type="OMA" id="NCLEIWN"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="15">
        <location>
            <begin position="5"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="280"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="657"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="692"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ76430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116865" checksum="B2944B05A9F6E835" modified="2013-03-06" version="1">MTTKWTAQKLRTAFLEYFQKNGHTIVESSSVLPHNDPTLLFVNSGMVQFKSMFLNQPCQFTGLKRAASIQRCIRAGGKHNDLEDVGFDTYHHTFFEMMGNWSFGDYGKEHAIDLAFRFLTEELRLDSSRMYVSYYVPENDGVAGLHADQETRTIWRKYLPETRILPFTAENFWEMGDTGPCGPCTEIHYDLTGTHGPEHVNTDDPACIEIWNLVFMQFYRDEQGVLSPLDALSVDTGMGMERVLGILNGTTNYGTDLFMPLFEMTGLSYDGVVLSEGEDRSMKGTAGVQQNADRITNGKDGDFSDVQRNADRIKNGKDGDFSDVQRNADRITNDKDDNYPTTRESDNSSSRSDHPKQSTNNFSDSVAQRIIADHARTIAVCLFYGVEFSSEGAGYVLRRITRRMIRVLHSKNVHDLPALVHKAAQILGTPLTDQQMAQLAHEHALFKKTLAQGVKYFNQFGTITAKEMFILKDTYGFPFDLTAQMCREKGIVVDRDELRRLVEQGVRRSKARKGARIGVKRAWAVEHARTAEFLQRDYAHFESTALFAFDEDAIVPLDELRERMKIGLVADRTCFYSEKGGQVGDTGVISFLDEHGRVVRTMSVCDTYKSGEYVVHYGVINGKAGGDCFEGDCFEGEGGCCKGEGDCCKGENDCCEEPKDGRDEGSVAKDGRGNNVKSDGKDLKKVNGSAGNDRHSKTINEQDGLRDKERDKEVKEGKESKDKEGNDTARAEKNAQALKLDMMVDLERRSKIRCNHTATHLLNHVLRTKYGSVQRGSLVADDRLRFDYTMDRKLENAEIKEIEDEVNEMIRKNAEVTVYERRYEEIRDSVVHLPDECYPEVVRIVDAGGARELCGGLHVRMLAHIRCFKIVSEGAISANTRRIIACTGERALECVSNALKIDGYVPGTCNDWEDNLGVLDRMRLLTIKQQKIKESTKMRKSRIRTYSTCTDNVVFADLAGDKKSVLKDLTAIFHNVSKKNAGVIVLARFDGVYPFVCGDVAANAEYVKRWGALHVVRVHGKLCGEIPRLDEKAFVDGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYT4</accession>
    <name>L7JYT4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0339"/>
    <dbReference type="HOGENOM" id="CLU_164232_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYT4"/>
    <dbReference type="OMA" id="KEHEYYV"/>
    <dbReference type="OrthoDB" id="10416066at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="123" mass="14712" checksum="F45282F05912450A" modified="2013-03-06" version="1">MRDIFNYFTTKHTSQRIRFSGSQNVLTLKKFGTHGMIKKRQIFTNALDRLKKEHSYYVKEKENVLEKIKKYNGSDEYELKLLNEMLTEVEQTILSVESNIQEYVSKLEKLEKEEKHAEKSYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYV2</accession>
    <name>L7JYV2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II transcription initiation factor TFIIA, large chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYV2"/>
    <dbReference type="STRING" id="72359.L7JYV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0528"/>
    <dbReference type="HOGENOM" id="CLU_030027_2_1_1"/>
    <dbReference type="InParanoid" id="L7JYV2"/>
    <dbReference type="OMA" id="KSKYKWR"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="122" mass="14287" checksum="C423BEC237949202" modified="2013-03-06" version="1">MSMFFEMSRVYRDIVEEVGRMLENESDVDLKKIHDLKVMWLNNLTERIENHGDVVQEPIVESASCSDSEDDIKGKNTQNFMMCLYDKVTKSKYKWRVNFKQGFLNIGNSDYAFSLGQGDLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ47</accession>
    <name>L7JZ47_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Negative regulator of transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ47"/>
    <dbReference type="STRING" id="72359.L7JZ47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0398"/>
    <dbReference type="HOGENOM" id="CLU_004563_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ47"/>
    <dbReference type="OMA" id="VEPTHIE"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="4">
        <location>
            <begin position="217"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="3">
        <location>
            <begin position="401"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="2">
        <location>
            <begin position="635"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="1">
        <location>
            <begin position="875"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1073" mass="126822" checksum="479E503588C2CF1B" modified="2013-03-06" version="1">MGKQIDESSITSIVLENESFRISADTFRDILLRVKRKREVEENEISELIKFIITTAEDWRINEIMVVLKENLTNINWIKVYELFDDKKFTISNQRSFSRILECWKCINGENTFPYRIFFKKWNNAETQENFLNYFIESREECLRVYNNVFLTRIITPEDLKRDKLKDDIHLESHFNCLEFFKILKELNQEEMIRRICVTSSEWVFLGLSSVYPFCSKIFDELFLQFLKKERILFLSVIFRNSPALLIKKLAEARDKGFSLNKLLDIILELKILPAILEIMNPSFFCYEILILSSRRDHLNLSIWITNAFKLKKDVFANSLIGYITEKFSRAEQLLKSSIKLDEETTAEKSLYPLTFEITLNILQTLEMLSNSFNREVLQSFNRLKMILPLELKNITEKKLSLEQQSNDFITSVVSGTRTVDQATEIIQSLVNGSLNERELAMKIFSTMLDNYHNFHRISSSKSLAFLFGRLIEKRLFPKFYMQKALRIIANLLKNVTTKEFRFALHTLSMFCDSQRKGEFDAFFEEISKIDKVKEFLQERKRSYVLEDDAIDEIAYDNFMDLLFMPLNGDIVVKLYAELREDQVENVFLRTLKYLMCDNVLNEREIDLDEFVVKTREMESKCIKNIDILIENDIKNDEHITKKINFFDNNSSTCTLDENPQCINQVYLCYLKQVNFSMNNTNLQHFLRYFFEKKIFETNNHFLLLRYFEHFGDDFYSLFCSLVFEMFRYLNKYRIDNEMRFAKSLGQFFGRFTIGMNRLYALDVFNMKEYVIGCVERKRIFFCVIFMVYFIRQGKFGLVFKPKNPFIMNLIYLLNEICEYTKDQLKEEIESLFAELKLTHVKQTSMLVNHVSMDNTTVVFLDSYNLGHFDKVHSKVISMGIDFSIREVTFPLMERIMNISMKTMNFLFRRRKDRKDEYVYDYKRNFMINLIGNLTVVCSLEPMCAAIIGNVPYFLKMAGLEVENERVHAVARNNIEKCNNIIRNAIVTKVLEDLERGPGTKTSQNDLHLLQTAPDVEPTHIEPIKQTEYQEVKEKLSKIQKKQPDKKLEHILAKVGCNSEGTGGIHQPGWQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZA5</accession>
    <name>L7JZA5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993818">
        <property type="protein sequence ID" value="ELQ76749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0258"/>
    <dbReference type="HOGENOM" id="CLU_1961247_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZA5"/>
    <dbReference type="OMA" id="ESAQIYM"/>
    <dbReference type="OrthoDB" id="10369031at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="132" mass="15086" checksum="2B80133E89DED60A" modified="2013-03-06" version="1" fragment="single">VLFKMHVIYTIIIFCLVPKISNAADLVLHIGTYVLRVVAVLLFLTCESAQIYMLRMVHLAIKSVDIGIIVARMVRAPIIGFNDMKRYIITLAFDLVINAGLIVLLYRDMQLFDIKLNEEIKKLERSNLVKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZM8</accession>
    <name>L7JZM8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0090"/>
    <dbReference type="HOGENOM" id="CLU_2943456_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZM8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="7046" checksum="48A699013C407587" modified="2013-03-06" version="1">MNLFIKKDYEILASMNKRSLSSWSALSAPRKFVWCVRKCEMLIKRTFNLKKSQLYSSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZU8</accession>
    <name>L7JZU8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993836">
        <property type="protein sequence ID" value="ELQ76566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0445"/>
    <dbReference type="HOGENOM" id="CLU_3020134_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZU8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6356" checksum="3D2F48BC7BD83789" modified="2013-03-06" version="1" fragment="single">VVREHAELYELVTDFLHEPNQMLAVVASLADQKNMHVVAISINKPIFVNKLISNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZX6</accession>
    <name>L7JZX6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZX6"/>
    <dbReference type="FunCoup" id="L7JZX6">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0747"/>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZX6"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="196" mass="21976" checksum="9F223B62C39E6F40" modified="2013-03-06" version="1">MSWAVQEVPECKLFNKFACKGVEVNDITLKPFINVESTIIVPHTASRLQRQYNGKSRIPITERFCCYMMKKGRNSGKKLLAMRCLEDAFTIVHILTGQNPLQVFVDAIINSGPREDSARIGRGGAMKRTSVDVSPTRRLNIALFLLSRGIRESAMKNVRTFAECIAEELIAAAKASPNSYAVKKRDEIERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZZ0</accession>
    <name>L7JZZ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0698"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZZ0"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="973" mass="112310" checksum="F25BB058334E7C73" modified="2013-03-06" version="1">MLANLHSYVEIVVKYILVFKTTSNEQPKDYMIFEDLKDTGIKCFLETCSLIKSEETPCTTSESDVNPAIKKFKRNHDDINYSTVYISKSFHERNIRNKSYETVMMEDRDTKFRVIEVPFSKNMFEKIYQLKKEKNIEFTDEEIGLIFYYLFPYKELIRNITYVICYNLQNNPKLVDRLFDIVSNPGIEHDKKMVHLSTIITGENVHGRNFRQAANSHVRFYLGDKECTYIAANKNRVCQDASYYKIELEKLNIAFLIEELNMPFAFLASNYDVIIKKFSSISVSSSLTLKIDNIDYDISAIKSNLVSETQILKHKLALISDNEFFKSDRIREIILVFVKVQIPLEQKIYDDISKLSMVICKSTSYDFFESIPEKIKKLGVVPTRKQMSAIIKSPRNIEKISLDEIKFKENISFPDHMRLIKIRSSKICLGVTITFGQNCTKIIIDNTEGTINFKEFAGVNFVLLKIEEYTLQKNLSFQKKNEFTGSFLKLFFIRVDGKLRLNDNFQKVDFDSVNVAPGSEISLCDQNTIIDITKSSGLFDLTPLIGTSLCFTDEMQFKTTSIEGSPKNFLNLSMKFIKSSTDVLLADCFEKVELSYTTMNDNTRVVLNDNCKTLIIECFDGIIDVSNKITWFDEIKISFPVDRQINISFIGSINTHHLCLNNACKEHETIVSMLSNFEGISHLKFTGKFTLAWNRTAPEYIRTLCMISQNTTKKVYYISMIREKRLPNHISSESLFYETSNVIATYILERALKESVLKMIQNVEFLSVEYNGNYEIFGRMESLQVLDFGTTNFENALFEHLPHNIKLLNISGPNNSEKSGIFKYKLSDLMKLIHCDNLKVLVIDANFIFQVGTLSFVPSSVKILKVHCKSKPKEIMLLDHQKIDLCELYIYNEKLGSNTHFIIRKDIDTQVCVEALQKYIKFESLEQLALVSSAGMAEIDINSLISLNILRKRIRSVFDVFNRYNSANFALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7K050</accession>
    <name>L7K050_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_0407</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K050"/>
    <dbReference type="FunCoup" id="L7K050">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0407"/>
    <dbReference type="HOGENOM" id="CLU_877646_0_0_1"/>
    <dbReference type="InParanoid" id="L7K050"/>
    <dbReference type="OMA" id="RKVICFG"/>
    <dbReference type="OrthoDB" id="2196211at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="83"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ76686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="360" mass="40484" checksum="3C48412097FD11F1" modified="2013-03-06" version="1">MSVMERLKQFRFVPFLTISWTDEKSLLFQNPQKNKTMIITLCQPLLDYRIADFDDIISLFELNNDDYMRITTEKTLNMFSSKQKIMTSLGGSSLNTFLKIKECTDIDLKFFGAIGDDKEGEDLCGLMTKSGVDFYFEKIAARGTGRCFIGLKRSKRILCTWLDASELMEPFFIEKNKNIVEQARIAYLSTFIISFNINTVHSFLKYLNDSVTLVINLGSEKLYSDDNMMFIQMLLKNAKVIIGNKSEANALIEKTLGGSVSTERGMAEISRKGTLFICTNGPESVKYAFNGEIHEVEVSKGRQVFQDTCGAGDAFAAGVLVGLYNNQATGECVKLGVEYALTTLEKNDKKLKKIMECTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K087</accession>
    <name>L7K087_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K087"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0545"/>
    <dbReference type="HOGENOM" id="CLU_3002298_0_0_1"/>
    <dbReference type="InParanoid" id="L7K087"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6562" checksum="8FD3D3229CFAA3F7" modified="2013-03-06" version="1" fragment="single">VVNSALRSRSSTFYIVKKWRDSGTKCNVITGMNKAIGNCNTSFVRIERKKNVYNNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0A5</accession>
    <name>L7K0A5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993837">
        <property type="protein sequence ID" value="ELQ76557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0A5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0451"/>
    <dbReference type="HOGENOM" id="CLU_2185950_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0A5"/>
    <dbReference type="OMA" id="HNERIFF"/>
    <dbReference type="OrthoDB" id="10310183at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="13174" checksum="A631673CEB5C0355" modified="2013-03-06" version="1">MKPPDNLNLTEHEFIEYLENECKEYIRSQILRIDEDKHAYLDDSIHNERIFFHTSYRNRIVPLTNCLESKHGVTIEIRNYDRYTECMYITGRLIEIEGVKSTLNEHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0B2</accession>
    <name>L7K0B2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone (DnaJ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993835">
        <property type="protein sequence ID" value="ELQ76572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0B2"/>
    <dbReference type="FunCoup" id="L7K0B2">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0441"/>
    <dbReference type="HOGENOM" id="CLU_119137_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0B2"/>
    <dbReference type="OMA" id="KMHPDRP"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="22434" checksum="AD3B1E5D115A2BEB" modified="2013-03-06" version="1">MLEDDLKSLNLTFSTLHNLKKNYTALVLKYHPDRKTGNREKFTQIFEAYKRILKYTQIHKEIQNMEEEYVGSEEERNDIIGYYTKFRGDMCRLLDHLVFGKYNDEDRIRRIIDEEIENKRVRRYKLYGKRISAYKKKRESTSGGDMEHLQAQILANREQRWQSFVDGMEKKYDCKQIEQSKSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0H9</accession>
    <name>L7K0H9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_0241</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="JH993816">
        <property type="protein sequence ID" value="ELQ76762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0H9"/>
    <dbReference type="STRING" id="72359.L7K0H9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0241"/>
    <dbReference type="HOGENOM" id="CLU_339242_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0H9"/>
    <dbReference type="OMA" id="EVHVKNR"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001456">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="351"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="553"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ76762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="838" mass="94248" checksum="505B2243CCC33119" modified="2013-03-06" version="1">MDLSSESDFIAAITEYNSKHSSTNVQHVISDSSDIIEQFIDSSDVRQYVNECDGRVNNGKVNNFIVSNGRVSDGRVNNTNINNVNDNVNGRVSNTNINNVNNNVNNKITNIVNPTITNTKQPTNPTITKTLTTPPQNNKNYKNVKIPHERMKDNNSLFNLEFTYDDLECVSVSTDLEEVGYKNGEQSKERNEGGVVDCKEIKGESTCMNDIIEELSDDVVESRHDLLDCSNDCDDSNDCGDSNDCDDIVIINSTISNHSPTVISRNRISINDKVGPTVSSSNRVGTNPIINTNPTINTNPTINTNPTCNTIVDPLCDAIPDTPLTTPTILTKTLTQIFKLRSFRPNQEEIINAVLDEKDVFVLMPTGGGKSLCYFLPAVLTHNLTVVISPLLSLIEDQIQELLRLNIASLTLNSAMSARERGVVFRALREGVRVGTAHKRIKILFLTPETLMQSDALQRMLKGNLARVVIDEAHCVSQWGNDFRPDYKKLRMVKDVFGCTVMALTATATRRVEQDIKECLFGAHAPNSPVLTFRSSFNRKNLKYIVLPKKKDTITQIVSFINTYYPRSPGIIYVISKREAEEVSHKLNGHITSLYYHAGLTKKERNAVQRKWSTDEVRVIVATVAFGMGINKRNVRYVIHHSMPYSLENYYQETGRAGRDGLQSTCILFYSYADKNRLNNLLKRQVERDNLSRVVQYCENVTECRRKLILQYFNERLTDSCTGCDNCQNTCNRVQRDCTQCARAIARVVHEHERLSLTHIVNVLRGSRSKAVCAYAGSACYGVLRDVRRSLLERVVRVMVGQGMLKEVHVKNRMGYVNVYFVVGPVKVGERVMVDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0I7</accession>
    <name>L7K0I7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0I7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0191"/>
    <dbReference type="HOGENOM" id="CLU_3360007_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0I7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="3991" checksum="AF136D05C4CB170A" modified="2013-03-06" version="1">MVSDPSGPKKSYCFLPLIMRKLKGYVCNDNGNEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0I9</accession>
    <name>L7K0I9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0I9"/>
    <dbReference type="STRING" id="72359.L7K0I9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0201"/>
    <dbReference type="HOGENOM" id="CLU_105494_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0I9"/>
    <dbReference type="OMA" id="FPFINFM"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="21780" checksum="EA7EE01749474B89" modified="2013-03-06" version="1">MESDAILELLMDAKSKYLKHYNNIKMKKLVDEAKYIKSEMEAIQETADFTDITEEVSKKYIFLKNTYDFYMRVKRSYELSRFLKIQKCFFSKQSNINMPNKKEGEHYVFFSTILEEYTSNFPELDFNVQYIPLDHFVHFITLADCGIVMDGDEIHELKANKYYFMKKNIVKHLLDSNLIRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0K7</accession>
    <name>L7K0K7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_0098</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0K7"/>
    <dbReference type="FunCoup" id="L7K0K7">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0K7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0098"/>
    <dbReference type="HOGENOM" id="CLU_037146_1_0_1"/>
    <dbReference type="InParanoid" id="L7K0K7"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ76902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="426" mass="48179" checksum="C7627BDD8B3052E6" modified="2013-03-06" version="1">MVKLSKHDQPYNLTHPLSHLPPNYNFELKKVLSTITRHKIRKVGLQLPDGLLKYSTILSDAIESNTGARVITLADVVYGACCVDTDADVELIVHYGHSCIVGSGGMKVLYVFVDVFFESDHLERMVRRMIDDDCGGRRGCGKDGESRGCGKDRESCRDGESRKCCKDGESRGCGKDGECRGCGKNNNSNNNNSNNDNSNINNANLTNDNLTNANLNNPPNITVLGTVQYRHIVYKLNKMFNLPSYQVKPLSTGEVLGCTSPKLKTTTVIFISDGRFHLESLMIANPTAQFYRYCPFNKRMYREHYDHERMYAVRAQQRGAFLRAQRVGIINGTLGAQGNSRIVRNVHDALVRMGKEVYVFNMEEVKESNLRFAFVEGYVQVCCPRLSIDWGHLYGTFMLCAYEVFNEKIQAMDFYSKEEVQPWNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRJ4</accession>
    <name>L7JRJ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRJ4"/>
    <dbReference type="STRING" id="72359.L7JRJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2989"/>
    <dbReference type="HOGENOM" id="CLU_367476_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRJ4"/>
    <dbReference type="OMA" id="MMGMDAI"/>
    <dbReference type="OrthoDB" id="10364067at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="759" mass="88326" checksum="735D02FAAE59C0A7" modified="2013-03-06" version="1" fragment="single">VADMQENDKEFQERKEEQIGKELPTGDKSTNINGQSVDFEDGNRLVERAYNDVNEDLVDKVISGNRGDKFDSNRELHVVIHDDDLKNFDKLSPDKMLSILNTLIAQLSDDNVHQIYAFLLNLQEHTLKIPSTHHESIKSSITTLSTNVMHFLPVEIEHYGLRLISVIDDTSERKVPFSTYLTNFLTSLLIKLTIKEIENAVNNYFYPEKRKIECGIEDIIENGFGALLAEEEDDNKNNDAHDEGKEDVKNELKSFDRTGTNENGDAYSTRRGNHEITENGRSVSGGSGKRVLQVERTNQRLYNEKGSNIDEISAKRMKYNATNGENVTNNNEKMMVKEVLLSNKTLFYILKDEDYNINLFLSLLGYEEKLQSFLLFLYINHENTYELFLKNVLSSCTAEQQPKILKNFIEVRVQDLKFFDKENLKEMVKKRMAKESLKLKLKEMEKGELLEIIKEDFKFFKNDLDYYDFSFKELLTLAEERDEIVEHLFDNLASYGTNWMGSVMKVLSGKNETFVLNFFQRRVRLLEDKTRANKEEEVHSLLYDAIVVYLKYNKPSKPLLQLFRSNCLLDNRKYFLNVITILEKETIKNRLMDYLDDETLPFFTRVITANEILYELCVFNCERYDREKGVKNGTKDRLEGIFKSIIPKFTEDTIIQTLASSDNTQNFFLALKYSLAAYVTLKPFTLTVLQRHSLRTSEYVDVLEMMGMDAIDVLVCKDKSFISYVLRRSKKIKDICARSKDRKLRGIEKVLEVYSNQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRS1</accession>
    <name>L7JRS1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3263275_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRS1"/>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="42" mass="4942" checksum="C85292937A2EC7D1" modified="2013-03-06" version="1" fragment="single">VYFANERPSSRIINHFITSCILKCIHDKKVDKSLNNERHGTR</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
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                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="116" mass="13128" checksum="E71D6B1CFC84F689" modified="2013-03-06" version="1">MKISQIKVIPSDRVKCIHKYSNYIVCGLFTGTLLFTADNTVKKQIKICNSAIRALASTTNLLVGTDDGEIVVLDPSLRRIKSIKAHNDFIRKIRTSKEYIFTCSDDFTIKRSKTMI</sequence>
</entry>
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            <fullName evidence="1">RNA-directed DNA polymerase, LTR Retrotransposon</fullName>
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    </protein>
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="EMBL" id="JH994079">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_215608_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRZ2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="5768" checksum="F0163B7E5CB37552" modified="2013-03-06" version="1" fragment="single">VEKGELTAICKGDLYLIRKSDRKILRKRHYDLKAYGVRNPSGGCYILIKD</sequence>
</entry>
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    <accession>L7JS50</accession>
    <name>L7JS50_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Putative Reverse transcriptase, LTR Retrotransposon protein</fullName>
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        <name evidence="2" type="ORF">THOM_2967</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ74115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="6467" checksum="EAAC32990A697F76" modified="2013-03-06" version="1">MINNAFYGIINVAAYLDDIIIFTLDAEEHKTVLEKVLQRFKQLNITINFDKLTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS82</accession>
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        <submittedName>
            <fullName evidence="1">Putative DNA mismatch repair protein MutS, core protein</fullName>
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        <name evidence="1" type="ORF">THOM_2741</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="InParanoid" id="L7JS82"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9237" checksum="1EE30E638FEA2113" modified="2013-03-06" version="1">MYELDNDMGDIENEIIDLELEILDELKIYTEKYTSQIKIAVDYISKLDVFNSLALAAQENGFVKPNISDKLQNEYLREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS93</accession>
    <name>L7JS93_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2711</name>
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    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2711"/>
    <dbReference type="HOGENOM" id="CLU_572649_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS93"/>
    <dbReference type="OMA" id="KENYRCK"/>
    <dbReference type="OrthoDB" id="10362929at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="477" mass="55798" checksum="3C78FE9562487635" modified="2013-03-06" version="1">MKKLLTKQKSPLILYGKTSNNKFYNPFYTIQTSHTSTLFTMLSYKLSPAYIKTKHSIVFTGHKIYEDFNYVYFKENYRCKKKLISDGVSVYRVVSNCEAVPYVPMKDEIGYVYSRMEIDGDRFLRGIDEMGCEYVVDGVRVVVKRINFGRIMSVRLVVDGWMRGYVQIGDVIDGVYEYEVVKECDGGNGRNDDRVNRGDGKITIGGRNDDKVDHRDETGINNSEKETRRKINAKESQINGNNPGHKNVPYQYKYVVHKEGVTGVFLSNKKYLIKDKVRLKVHRFDDGRYLFKEDDSVDLSVAWTEECTNKPSVAQNTYRSTSCQLSTAHKNEKVPHTCLPDITVHNLQAMEMPAFKRKLKKYKRHLQDLKDVFTGEKNIEVYKQIFLMLRTRRSYIEYIQKDSSAFLEYPKYYHIGISVLEDYDRWFERINRTKKVWLAYLKRTGNVGVQRCLEEMRGKEREFFVGYFRSAGLLNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSD7</accession>
    <name>L7JSD7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2707"/>
    <dbReference type="HOGENOM" id="CLU_1807687_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSD7"/>
    <dbReference type="OMA" id="HMLLFIL"/>
    <dbReference type="OrthoDB" id="10297766at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978770" evidence="1">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="17834" checksum="AEC0FB8F2EA327B7" modified="2013-03-06" version="1">MFHPTYKRGCIVKHMLLFILSVVSESFKLQSAAIPDFFIGENQTKKLTLVEEPFADVFVLEFAGLNKDDIVAVPTKGGVIWELDEALGRLSYTDLKHGGLGQRFKIVKRPFGLYKIMNGGSGCVTLDFRTEDFRKTTCNDDDLKQFFRLIEMPTRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSE1</accession>
    <name>L7JSE1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2883"/>
    <dbReference type="HOGENOM" id="CLU_426535_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSE1"/>
    <dbReference type="OMA" id="RNDCLLR"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="642" mass="72638" checksum="03AD9828248669D6" modified="2013-03-06" version="1">MRIDNVVDMTSKLLDRMVQVRKRRKNAVNTLLDCESVRVERKVAVWEKEMRDVRRCSVRNDCLLRILGVDRTGCMAVLDDVPATNRRINYGAFLCSTELHDHLRKIRFADLFVCPTLKGVTGNENVEDIDLDNFLDIDEHVLENDVLVDGPSVDHEVHNDAIDECVGNDGDECVLVDRFDATPFAYHKAWAGPQNWRILTRRTAGTAVKRAKKDFLEQFDRKVLEDRRSSLLKEEDVLKRRADDKCIVKDYGVVKEDLYALGMLNESFGVHSSVNAHEGINRDNTIHAHNRENNMPDNSIINSFIDHSTRDINAEHVPPPIEDELPTGGPLTTTGAHLLKRYARVPKRVDIKRLEQHISTVMKQKGQLNIKDAFYAVKDCYGEKERGDVSWQIMFVGVLELAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSE4</accession>
    <name>L7JSE4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Myosin head, motor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2888"/>
    <dbReference type="HOGENOM" id="CLU_284784_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSE4"/>
    <dbReference type="OMA" id="CSVIDIF"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="866"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123765" checksum="324E7835BF37BFEF" modified="2013-03-06" version="1" fragment="single">VWVRVFNRCSVIDIFGFECVERNGYEQFLINYANEKMQRCYLRELVVEREREYLREGIIDCRGEMRGMVGSVDREEMVGSIDREGVVGSVDREGMVGSVDRYDKHNDRYDKHNDRYSTPTNNSTPNHTLNHLNHTPSNSPTPNNAPTPTLNHLNITLSPHLQTPLTLNNNILHLIENKTGIINIIKDESKLKTDLITKIRSFNNTAIIKAHNDRLTLMHSIGEVTYDVGEFVRRNNYDLVDSYRREVDRMVDEIVNPMFVRCIKPNRSNRSVDEGSVDEGIEDSCSVESIDEDRDNEGRFSDNDNNDNTTTSPSNPAINTNPTTINTNPTTTINTTTTRHSNPTTTRHSNPTTTRHSNPTTTRHSNPTTTINTNHTTVKYDKKYVKAQLLISGILNILQMSTYEKKIPLAVFNSLQCTQCNFKLRINHKKGRNYVYMNEEEYVRMNRCIDVMRCGVWRRVRAMARYVIWKHKLRTNEDIVGNDNSVSNGKDSNNILNTTRPTIPTTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXANTIDNFCLSLAKKIYNLSLLIQMHIQSALFTTSSPTTRLHVLSLGNLSFIYVRKTGISDIYFYNEIKRRVLMYEDNVRVIGYVLSNVMEYNSFLCGMVEDVEDEDVCGLVYSTRYGDDNGCMVSLRDVFGNGRGSRGGDERGGDGSSGRGDGNNKDRSSGRVTNPTSTDHHSIANPTTPTIITNNLNFMLSLQFSITNHFINLIIFDLKHNINIFKSSFLFRRNKIHHLTTTLKRFYTLMVNLHFPTSTLHNIMNHLLQYINTEIFNKLLTNVREYERVKQLLRALLSMLTEIEYVEGMLNLKHLEESVVLIESGSSARCFALSTGQIDCLVAAYYNSGVVVDESVRLRLCGFVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSH6</accession>
    <name>L7JSH6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2617"/>
    <dbReference type="HOGENOM" id="CLU_059138_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSH6"/>
    <dbReference type="OMA" id="LTECINA"/>
    <dbReference type="OrthoDB" id="10529272at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="452" mass="52733" checksum="59192569275A132C" modified="2013-03-06" version="1">MRFYIAEKLPKELKFLIFKNIKIESMSKIIINKSCEYLKLDTCNGCFDVQKAKNLKKVIFVNCITVFDNHTWKCIYLDSDNHNMYKIKNITFPDNIRSVVFERIITKKKLIMIINAACEEISIDTCECHFDLSKIVRLRSIKLIYQECHRYEIVLPDLTHVKTLEMSCDKLCCDFEKLLTECINATKLILHNIKCDLHDQTKTVTCFFPVKDDFSLALNQFMSNSESQNDSPKCNQPTIFAIDLGLYFYIIFKRHRYKTLQYLSISGISLDERGLKFIKNFIMLKTLSMVFQNILSNIFIALPPGLEQFIITPILCQQNQELKIIPGKILFNENANMCHKMLKILRIYLGLIVNKSQLVPFLVAIDTLEIIPAIVEWCPDPLNNRKVKVRKLVILKVDCELKKIVEETSTMEEYYDGVLDLLAYFVDFSDITQIIVQDENSERFVNLSDYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSJ2</accession>
    <name>L7JSJ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Endonuclease/exonuclease/phosphatase, putative transposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2837"/>
    <dbReference type="HOGENOM" id="CLU_1240898_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSJ2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="223" mass="25066" checksum="373D957518C42DC5" modified="2013-03-06" version="1">MSVLKEDDNFITGILEVKSNNDVKFTNLIVNVYIPGKGTERRSALDRLAAFILTTKSTKRFSEIIMTGDWNALPKTTLSALQNRGLSLPNEALTFNQSTRLSNRQGRCIDYPVATNSTSIKTIKVLRKYDMSDHFPILIQIAANVDKTSQTVLRINNDTLNNNRSARLRILNDIRWNAVVNITGHKKMEIFTSIANSILSETGVINPVNEKRVHSLPEKQRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSJ3</accession>
    <name>L7JSJ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSJ3"/>
    <dbReference type="STRING" id="72359.L7JSJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2697"/>
    <dbReference type="HOGENOM" id="CLU_2039706_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSJ3"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="14481" checksum="D81ED73EA6219403" modified="2013-03-06" version="1">MPRVNVSFGMYISNRWAYKTECIIFSSSLYLLIPSYFKERKRFYCMHHNRINPNKQSRRQIIVYQDYFNGILKGLHSNITLHNVAIHWSIKNANRMCQVDVNTENVDHDKIDIDFKCKHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSY7</accession>
    <name>L7JSY7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mismatch repair ATPase MSH2 (MutS family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSY7"/>
    <dbReference type="STRING" id="72359.L7JSY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2653"/>
    <dbReference type="HOGENOM" id="CLU_002472_8_1_1"/>
    <dbReference type="InParanoid" id="L7JSY7"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="4">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="201" mass="22103" checksum="DAFD066EF607E6F6" modified="2013-03-06" version="1">MARDAFHPLVNNCIKNDINVNFTILTGPNTAGKSTFLKTIALTVILGQMGSLVPGREVKFELRDGIYIRSGASDKYGISTFMREMKDIARITNMCTEKSLILIDELGRGTSYIDGISLSVAIKEYLLKKKALAVFATHFTGKNEKMFLDGQDVDLLCSEVVDGVITYKIKKGVANSLGIDVAKRVGFPKEVINAAEKYLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT18</accession>
    <name>L7JT18_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SWI/SNF transcription activation complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT18"/>
    <dbReference type="FunCoup" id="L7JT18">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2639"/>
    <dbReference type="HOGENOM" id="CLU_069185_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT18"/>
    <dbReference type="OMA" id="NFRCNEP"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="1">
        <location>
            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="340" mass="40405" checksum="228E4B0CEA3FA1D7" modified="2013-03-06" version="1">MTLLDLYEKLRVLEMHLDKAVLKKKLLVEESHYKRIKCAKRLRLFINFERFEDSFLLKLDGRVINDLTNTTELRMSDVLKNVCVKLDFEDKEEDSGKKIKSNDGSYVQPEKTVREFYEWRKSKNDMLDCFELNLEAKPEKITVLFEFENTFDRYKLISPVRQLFKKETETKTGLLIDIWKYIRLNRLVIEADDFTVVCDEKLKEIFGCDQFKILDMPELVSPLLLPLDPLILEIPVQKNYTSNFDVPIDVDDFYEFPVMYTNNVIFQLDQKIAGLFDILKRNNAKYEVLKKFAANPNSFINDWIIKQGHLLKESKFDVNNKTFYDPMIQETIFNMLQSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT29</accession>
    <name>L7JT29_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2416"/>
    <dbReference type="HOGENOM" id="CLU_3162572_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT29"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5224" checksum="82036CFD78B04CB7" modified="2013-03-06" version="1" fragment="single">VPADGAVNNPKLNIQRVILNVQHGQTARLHLGSRGGCYHSGLLVILHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT66</accession>
    <name>L7JT66_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2867"/>
    <dbReference type="HOGENOM" id="CLU_381389_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT66"/>
    <dbReference type="OMA" id="RERMCKS"/>
    <dbReference type="OrthoDB" id="10468872at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="726" mass="82526" checksum="6D987064E9F7213C" modified="2013-03-06" version="1">MQSVITVVLYFCFPVFIGTCSATFYLLAKPLLMNLKFEKINKRDGVQKIGCSSQGVYILKKDMALITESGETYATGCKNFACFENDILVYDGSDLIISDKRFSVGKCSDIFLNDNIGVLKDGTLTIYDRTFKVLEEFKGVSNAGFLSDGFIVEPCNSGSILRIYKKLEMVEELKGKLLFCKENVYGIQNERVIIFKNYKEQQHFDSKENKILLAELGDIQIFYDDEEFRYFYKGEEVINEEEGELLVMSLDERGESVELSDIILFDNRAYLLGANGTLIWYKMIVENDKNVNEKSNIQVSVLDTDPDLDFSDFSPSKSTIVTNTTKQGITKGQPNDPKTQEISNKLLDVFKSSTLFSSQTSTLKPDLFINTGRNSKAGDTSQKTNVIEKIQANDKSIAPSLDKTRILNTNLDIFSDIETEPGEIKSPSVANSTKNRGEINTRGMHSSTADLFSRSSNVTNPINFPSIHKKETPRTSTETTPKNPDEILKASLRSDINSLMHDFMSIKINTYQFATIDDFPEDENYELMYKKLKFLETVNENSIKVELSRLTATLNRKISIKNYIDYFDKKIKVLKTARYLIKDKSAPVYDSAFSNRQLEMKFRKNLKLLDEKVLNRLDELEKREKARKDEQIKAEMTVNVQPLPNDTTYLPSRNGPVSTFHPPPAQQSIFQAAPIFTPQNIFPPNIANNIQNSPNTSSTANTKRTSTFSRFLNKQNDVLKEMEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTF3</accession>
    <name>L7JTF3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994082">
        <property type="protein sequence ID" value="ELQ74042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTF3"/>
    <dbReference type="STRING" id="72359.L7JTF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3044"/>
    <dbReference type="HOGENOM" id="CLU_529121_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTF3"/>
    <dbReference type="OrthoDB" id="2193130at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979124" evidence="2">
        <location>
            <begin position="27"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="515" mass="59173" checksum="DD194E469CE17927" modified="2013-03-06" version="1">MIITINKKHLCFFAMLFSFLFQLVLSIDLENTLKEFFSDNRWKDLLKEINKELKSGKLVEQTNANTEELNRSEIIEAEMANDNCHVDKKKCDERDGMPKNETSNVKDNESADITKKLFSLLSFDSLDDKKNGSREKRAISEREKKAETSGDETAKKDTNNKKVVEEGKKRINKDKVMQTQESSATREDNNGDKNGDRYKEKIKGENSASEKSEDNSENSGKSIKEDMTLETKTESSKEERSSSNGSKDTPSEKEGTKYSTLEINHTVTENDTKNKGLSDKLKDIIIAIKKMNKKTKSPQKILITFDPTTNKLTIRIMPVVQVNEEDMKLINGGIRVLNAFEWNRNILKSLFPKDMYGKIENVLIYKNKKGEYEEYWGKIKFHKNDNDEYVDETGFLRGKLVSSLKEIIEKGKLTDTGFFQSKDMSDEQLKKSFQAMKVLISEIARIKNKRIVDVMNEELRMTSLDKLIFEKNYKEKSTGPDGCVYVCECKNAGCENGCEEIKCVDRAKLNELYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTH5</accession>
    <name>L7JTH5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Signal recognition particle receptor, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_3014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTH5"/>
    <dbReference type="FunCoup" id="L7JTH5">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3014"/>
    <dbReference type="HOGENOM" id="CLU_009301_3_1_1"/>
    <dbReference type="InParanoid" id="L7JTH5"/>
    <dbReference type="OMA" id="SKLCYHF"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="6">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="387" mass="43621" checksum="F75B892FB45F4F1E" modified="2013-03-06" version="1">MLLYSTIFDLHGNVHHQSGTKPSYINNIIDTVVRKNIKHGELTVQGRNVAYRTVGKKVIMCVGDDADEQIERMAAEYLEDGAVREHGVYDRRAAVTKQEKRRRWGGTEKELDYSSTSRTVSYVPDTKSAFNLFNIKRRVFKTFDREALLAHLLNKNVAPEVAGDVLMYAESIDDVRDAMRSIIKTKRLGQDACAPYRVALVGTNGVGKTTTLSKLCYHFAVRDKGVYVAACDTFRAGAIEQLQTYVNRLKINHRVEIHQQGYNKEEWKVARSALQYGKAYDVILVDTAGRVNKKPLIDSLRKLTNLGFDDVVYVSEALKGYEKDVLAFDMVTAIIVTKIDTVDDRIGSILNLCYFSKKPVVFLGHGQSNVDLEEVDVEKVIETLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTI7</accession>
    <name>L7JTI7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2724"/>
    <dbReference type="HOGENOM" id="CLU_3160281_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTI7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5781" checksum="CB3BA2E22B485675" modified="2013-03-06" version="1">MARLCFGVWNDYTNEMMVMVRMVGDRGEVFYFLSNFMFSYLLHPTNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTJ5</accession>
    <name>L7JTJ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2429"/>
    <dbReference type="HOGENOM" id="CLU_2308199_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTJ5"/>
    <dbReference type="OMA" id="WIRFYGY"/>
    <dbReference type="OrthoDB" id="2187214at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="13063" checksum="CE3D4A2D6D715FFC" modified="2013-03-06" version="1">MFRYYFFLYPMFRTLCEHGRNGKIHSFGRIKEVLNCNTVIIEYKTLVLRFVCDDVGVTCREGGWIRFYGYLEDDAILGTFYVCLDGVDINLIEKVAFYVKRAKKHLWIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTK9</accession>
    <name>L7JTK9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2342"/>
    <dbReference type="HOGENOM" id="CLU_2190375_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTK9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="12072" checksum="1BE27BEF67E55331" modified="2013-03-06" version="1" fragment="single">VLPDDTPFATHSDSPSDINFICTTTESHTSPEENIIMNENAKCNASELIAIIVVCYFIFLIFASLNLWIVHKIIKVCSTTGSPVRSKGKSNYSQSNSKYAKLNRSRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTL3</accession>
    <name>L7JTL3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2689"/>
    <dbReference type="HOGENOM" id="CLU_3299686_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTL3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="4757" checksum="268AEA92D326D339" modified="2013-03-06" version="1">MKEILDSFMRRATENEKLFIKRIDASEWMNVLLGDARISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTN7</accession>
    <name>L7JTN7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994072">
        <property type="protein sequence ID" value="ELQ74122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2949"/>
    <dbReference type="HOGENOM" id="CLU_350099_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTN7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="805" mass="91527" checksum="01BF9A0D7C957A63" modified="2013-03-06" version="1" fragment="single">VKEEIREEEINELIESVTFDPISSHINKHNYDMELAFKPKDIDEIDNKCEDQSTKDSISNNSSSQSHAEDDIYKYVHSTYAEILCTEGYVIDERRSKTRIRFGTNTSRPGKGKSRTVTSKKEISECSNDINDGVSSQRARCEEDSDTAKLYRPISNANPIFDQQFYEVNRSNVNLINDQEVCEGGKDGTREGNINNPDNSLKSSSGILLDTLSLVDPVLSDEPTFAQSDIVLSPAYERHESLSVVDYEKREVDNTRGISVIRPIFTMYESLPVYLDEKGVSNSCVNEENVDKGIIESNNGAIQSHTNTNTVERSDVIARNRGHAEMLASNVSATADLAFSRESVIKSKDAANISEVPACSGDCFAKHALKFSGGTAFNKTLERILGGEWQNSTSFICELKCGKKHIHSSRLTRENFQWILSTYSAELWNMFISSCQVQKNPTRDVNIRNAILCEDGIVLVKHEAHLYSSVIFSDQLFPEESCFKKMPRTLSVLVNAESHENECLETITECCYDFASFDMLLSEESYEKYISETKSLWNATKILTINSAERYDALVRYLTCDPAAFNDVDGRTILNEHIAVQCSFCRFEYPASILMPSRDVFSRLLELNLASFFRHNIGIKFIFMPEILSLKLFLCTRGKINAYSTKFQDLLLLYSLSNLCAIFDHIHKNFTKSFQETSIVAFKHRFAPFIFFIRDLYFLDLLQGFALQPFVQAQYVLLYHSDLLHSLKNLDCVIPETRKSFDPFLMIFSIFFQTTPIQECNVSKICDLSAFLEETENYKFDMHLIITHFSKSDVLLKSVGDSKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTT8</accession>
    <name>L7JTT8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2566"/>
    <dbReference type="HOGENOM" id="CLU_008228_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTT8"/>
    <dbReference type="OMA" id="IRISECE"/>
    <dbReference type="OrthoDB" id="10548146at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="881" mass="100935" checksum="8DB51D90A5B34DB4" modified="2013-03-06" version="1" fragment="single">VDSETYIMPIFINEFNMYYVVHCLIMDYRFLEDNEQLLADKFNIDSTKWNFSLQIDFKFQIKEKNETAIDKINTLLNCSFVNCESINNLKICFYDTNMKLNTMNIPNKKSTICLTNCGPDLLSSLPKNFTELHMYYMKIVQSVILQKSINFVLCKNISMQDNVKISIPKECANLTLTNVEGIIECANLGIVKCLKDSWFDYSRDNDGYLGFSMMHVICQSDFEIHGNYMNLVLDDIVFDSQYIMKFTGILLNASIGNCVGTINFQETEYSDTFTLIKISLSNCRVILPKAIGTLTFYDVHIPHKLMINSYIDFLCINSVKIETGQALTVQFRCIRVDIDCSSGMFKLFDEIIQELQNDSSKQNFIYKQRVNDLFVIKEKSLRLEMNSKVVKSSTIVYMADVIFEDPIFWVINNHIESFVLYNVKGTISLTGIITGEFFGNDSGSLSIVRVKRAAPPTITIKGLIVRKPVDINCILDSLTLENIKYDVSELILRVYYRCSNINVCMYTGLLTISSLSLVDVHLTKAILIYNEVENSLTINGETKLGRYSLPSHIRHLFLNMVVMTASNVFYLHETLTTIEISNCKGLFVFKGLFDIYKLELEEMSTIKFHAVAENLVTLELCNLTIKNSIFAENCIIELILKEIHSRNYSIFKIGSTCLLISVINSSCEIHLKNKDKTVKIVCRKGEKYIFWREDLSELFHLELIKSFLSRKIVLPDNIQHASFKEVHGTIKYPIIINDACTKVEITKCSGVIKCLNVKNLDSISVNEFSDHNLEIHLEISRSLVIRIVYEFTGTDAICIYIHLEISCHLSFSQHSLEDTLTKPLRIILQPKPHLNVNTVDNVMYDDQNQYVFVHGSSLDTTEVLKRHLNSNEGKKRIPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTU8</accession>
    <name>L7JTU8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2328"/>
    <dbReference type="HOGENOM" id="CLU_692962_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTU8"/>
    <dbReference type="OrthoDB" id="10478812at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="398" mass="46102" checksum="C2BFCF37FDF0D794" modified="2013-03-06" version="1">MIIAPVLSIVYYGQLYYSKANTLFVDGKECQRSSFIIHRIICHNRYIILCGITELEILYVLRCKMLDGWKCRKGACGKYIAKKERDKYQSWFLLKHRVPKHRWIVRPKAIKNTSGVHTSALLGEISVNGRILDALIAFNSLYILSDRFLYKNQRKIFIFSECITAGKLIKKVFNTQDMPDCMTYYENQSKQRTLPVTAIIGTVDGRVVTNGFDRKLFDGIVTHISCFKNYVLACSEDRTIVLIKNWTDVDILHVELRGSVYQCGLRGLNNYFAFTECGNVFFNGEKFTFPYKSVCSATFYKGTVLVGLKNGGIMMCKKREFECLNTNRTFSSGQDFFLLDEKQHIVRNNVILYDLSGVKEKIVDFYLKPRIMALRLKDKVWLLWSVPKESVRDKNRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTW0</accession>
    <name>L7JTW0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2169"/>
    <dbReference type="HOGENOM" id="CLU_3056295_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTW0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6107" checksum="E4CA5D697EA16148" modified="2013-03-06" version="1" fragment="single">VHKRYTLEVLTWGASRSLVVNSKRTTVMVIRYFGRSVLSVVGICVVLEGWAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU11</accession>
    <name>L7JU11_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994001">
        <property type="protein sequence ID" value="ELQ74973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2084"/>
    <dbReference type="HOGENOM" id="CLU_2924359_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU11"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="7072" checksum="B08686A463B639AC" modified="2013-03-06" version="1">MIVGISRERMPAARDELRLYVDCDYARCIVFARLNPLMCKKLANRHKKQSAIRRVSDPAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU36</accession>
    <name>L7JU36_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994022">
        <property type="protein sequence ID" value="ELQ74815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2253"/>
    <dbReference type="HOGENOM" id="CLU_1908169_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU36"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979148" evidence="2">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="133" mass="15149" checksum="2B03B3E64AF760F7" modified="2013-03-06" version="1">MINVYYTLSIILYVALVLTGVLNQESEIKNDPSRKNQVLIPQQQRIVCNTFYARCDRNGIKEDNSSNDRTLCCENTDAKRNASLGSYNDALNSNGNEEDNGSDEVSLVPVKNVEDMDRKKKKKVRFDIPEKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU78</accession>
    <name>L7JU78_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU78"/>
    <dbReference type="STRING" id="72359.L7JU78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2221"/>
    <dbReference type="HOGENOM" id="CLU_961594_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU78"/>
    <dbReference type="OMA" id="HRENKHY"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF5">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="290" mass="32611" checksum="13C46D5AB886EFB8" modified="2013-03-06" version="1" fragment="single">VSLKQHKKMYKQKKIAKFMKTINTVSPKERISMLHTFPENAACNDCKSTNPTWANLNFGVLLCTACAGTHRENKHYKVRSLLFDRLSDDEVLRVLVGGNGNHFGDSDDVTGKYREYGWYVDELTERVRRLKESGGCVDDEVVHDAGDKAGVRMERTLKIVKTKRTTKIGSKSIEELRKKRESEGMKDKAVVKEVKKQVVVKEVKPKAVQETKLNEPTVVTFERGTGAYTLKGQPSGDVGLLDTKSEDVNGNGYNYKNIKFHSVKKEKSVIKKVAEGSKNVVSGLINKFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU88</accession>
    <name>L7JU88_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MED18</name>
        <name evidence="2" type="ORF">THOM_2199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994013">
        <property type="protein sequence ID" value="ELQ74870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2199"/>
    <dbReference type="HOGENOM" id="CLU_1645002_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU88"/>
    <dbReference type="OMA" id="CRINVMD"/>
    <dbReference type="OrthoDB" id="10338093at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="178" mass="21054" checksum="E011763A27472718" modified="2013-03-06" version="1">MCDLNFYSFMNSSYPLIMMNPLLECALYSYTMETALLHDKLMDLKFKKKDLHIHRKLYKKDGHIVVHDIKNKKLVNKSEPDHNRNRSVIACRINVMDIIECHNVNTFMQEMGYTYCEELVLDGYKYYKGNLTIDLLKVEDKVEYVVHAYLWTTDLQEGEFILTNLSNEISEIIQLTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUG8</accession>
    <name>L7JUG8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994032">
        <property type="protein sequence ID" value="ELQ74661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2412"/>
    <dbReference type="HOGENOM" id="CLU_742243_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUG8"/>
    <dbReference type="OMA" id="NAWFNLH"/>
    <dbReference type="OrthoDB" id="10510275at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="373" mass="44465" checksum="EE5E5971B3DA242C" modified="2013-03-06" version="1">MYFFHKDNPLMVLYILFIFWFKNFCICAASDDMLTVRILLQKLEDDSKCCEHELFLENIKEGLPQTHTNRAYYNAWFNLHVFLGYFDMIIHVFTNYIKTCSEDSTIDVSPLFYCDCSLLLDLTHCYTLEAPRKRDNEGFEYIKQIINTYDILLTNHQQTLKKMPNLRVFLRNISKLIEALKRVVYMPVLNIEADLQKKIIMTLSLTMFYKAIEENFTLSRTNSAVNNESDVVVDLDENREASVESYTYEDLNERVCVKTNSLEYIMHTINETYLFIRKYESEFLEASTNLKKIIDYNLILSTVNEYYKLIRSRRSVISAKEYMLIYLLNNIQLNYQLDDIRKLKTYYTMNISKKIMNYEEWNAVVEAWVEIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUM0</accession>
    <name>L7JUM0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_1958</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUM0"/>
    <dbReference type="FunCoup" id="L7JUM0">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1958"/>
    <dbReference type="HOGENOM" id="CLU_677867_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUM0"/>
    <dbReference type="OMA" id="CPPISYH"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="12">
        <location>
            <begin position="175"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="340"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ75124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="413" mass="48005" checksum="57BA1EDAC6A8AD66" modified="2013-03-06" version="1">MSDHFKDLLYANALINTTNNFVPINVTRHPSKFPADKVVEALKLQKVMNILLYKAIKDHATYEISTMDEIYNMLVKMKRTNNKKKLTLIYMRTDYLLNKDYVLKQVEINTISVAFVELNPRLNKVHSVEHKNVWLPENMPKFVQMVTLVRDSFIETNGYNDVIALLLDDNTSLQSANFFEKKNLIFELAAKGITMLHVTAKDIEIKGVFENDKFIYDGKCVFFVYLRYFYNYDHHDDNIMELRRRIENSDAVTLPSIELQIIGLKMFQVIFESKDVLRKYLSDAQVKSIYDHFGDFKNIKDYQTGDENTYILKSMREGGNTIITEDFQNYINEPDKYFLMKKIDSITVSNRFYTEKDDVDMILELGVLGTLIEYDGNVILNEPSGFICRSKKKGSNECGVTCNYGGLDSVYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUQ5</accession>
    <name>L7JUQ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein particle (TRAPP) complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUQ5"/>
    <dbReference type="FunCoup" id="L7JUQ5">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2597"/>
    <dbReference type="HOGENOM" id="CLU_1732870_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUQ5"/>
    <dbReference type="OMA" id="ANLFDCD"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="162" mass="18199" checksum="773D0897B2E64FB0" modified="2013-03-06" version="1" fragment="single">VLILSIRKHPSMSKVSANFVQFFSCGFIHHLLAQGTTDIKTSYRDIGHKLAPKLLEMYKIHQTNDLDKMLLNIKSILANLYSSKRSISITSDREYYVITESDPLLSRSGVKSLNSNNLIAGLIEGLLDANLFDCDVLVSDGSDESNPNQVYYLIKNRKGTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUU1</accession>
    <name>L7JUU1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUU1"/>
    <dbReference type="FunCoup" id="L7JUU1">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1895"/>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_1"/>
    <dbReference type="InParanoid" id="L7JUU1"/>
    <dbReference type="OMA" id="KTHCRDM"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="136" mass="15410" checksum="FEB80F736DC4C37E" modified="2013-03-06" version="1">MQASETTKRRTFKKFTYQGVDLDDLKTMPLCNLKALLPSALRRHINRGFSEEEYTLIKQCERNEPDIKTKCRNMMILPVMIGQVVGVHNGCNFVEIDVKPEMIGRRFKDLVPTKTSKAHGRPGVGATSSSKFVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUY1</accession>
    <name>L7JUY1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_1832</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUY1"/>
    <dbReference type="STRING" id="72359.L7JUY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1832"/>
    <dbReference type="HOGENOM" id="CLU_065181_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUY1"/>
    <dbReference type="OMA" id="NEICKHR"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ75209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="315" mass="37246" checksum="571AD72FBF0CBAEC" modified="2013-03-06" version="1">MILAVFIPMIFARLLLRNKSDFRRQLNEICKHRAFSRIEMDFSNTCLFPELMKECKLWECLFSEAGNLKRIEKNGESRMIVDLLLNPESYTGYKKGSSEIWEKLKGINDSELYKIMLSGIHQSVNIHKAAFYKPCGYNFLKNVMLFRKTCRNDAFIGNFKILRLFLLTSLKKLELAENIKYKWLEGLKSCVLIEIPLFPHIKRLSKDLEDAIDILSCMPCPKCRLWSTIQFKGLGVAAKIIAGEKISQQDLVFFINFLNRICVADTEFDVMEDMLSNYYWHIFLLYKKNFLRCAWPYYCFWLYWSTKQLIIKILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV23</accession>
    <name>L7JV23_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5096 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2526"/>
    <dbReference type="HOGENOM" id="CLU_1788171_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV23"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031512">
        <property type="entry name" value="DUF5096"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17019">
        <property type="entry name" value="DUF5096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5096" evidence="1">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="145" mass="16428" checksum="6B633F6D209D1D63" modified="2013-03-06" version="1">MEEYLEHNITVQTASSLISGILKRIDTDNGLIYVQEKNMQSLTQILFSHVENLELNDIDPKELNDPAIVEAGEYLDGHEKSDYLFEEKNKYASLFVDMTSEQRKNIIGEAYDNYGPSREEAASIAACYSINFLKTTSLAPKNRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV57</accession>
    <name>L7JV57_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Apoptosis inhibitor IAP1, BIR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV57"/>
    <dbReference type="STRING" id="72359.L7JV57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2120"/>
    <dbReference type="HOGENOM" id="CLU_097614_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV57"/>
    <dbReference type="OMA" id="MTTTCYL"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="253" mass="29888" checksum="410695DBA361D9EB" modified="2013-03-06" version="1">MPFPSLQSRLDTYEKSKKNHRKTNSLDFALCGLYMYSSENHMTTTCYLCGKTLSYWLDDDIPFIEHLKRHKNCPLYQLYDASQRELTFVGLKMPIVRKRKLAQRGFFAYPLKTGHIDLFCYKCGYYVNDFPGPSSYQMRYHDEKCNFNHDYVLKSPNDYSKNAHGLFFIDLLSGRYKNIISSYLQHPPIHMNESLACDLGQLLRFRGKNAFLFTTKHALQQCLDNMLEYTRKQMENDENKINNLVEELDDDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV61</accession>
    <name>L7JV61_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2125"/>
    <dbReference type="HOGENOM" id="CLU_1176131_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV61"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="236" mass="26254" checksum="A9B27A1CBE4E057F" modified="2013-03-06" version="1">MYTLRITAPYYYTYIVLNSNFPIFYNFSMCYNLRHTLRMNDAIMRFIFDFPVDVPRKAIPCFDGVDTFYSAVEVGMGGLERVKRGLKGIYDIMRSNEDDEIVDDGVVDDVVVGGGNGDDEVVGGGNEDDGVLGGGIKDNHVGSNREFSEVGDINGDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV74</accession>
    <name>L7JV74_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2431"/>
    <dbReference type="HOGENOM" id="CLU_2016817_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV74"/>
    <dbReference type="OMA" id="CMKKMER"/>
    <dbReference type="OrthoDB" id="10455450at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="123" mass="14876" checksum="E98AB565DBA502DE" modified="2013-03-06" version="1">MSNRIQNRTLTRRNAKKLNENTTKKKRKIPSTTAKNRVSRLNNINYYEITSEGMSKSKESDYVKRLESPENSFRVKISDSFNWSEYDRYLREEIEQETYENECLITHAELFIDCMKKMEREFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV94</accession>
    <name>L7JV94_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1735"/>
    <dbReference type="HOGENOM" id="CLU_738100_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV94"/>
    <dbReference type="OMA" id="FTREDNM"/>
    <dbReference type="OrthoDB" id="10327868at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="422" mass="48500" checksum="3B5C1A128698FAC7" modified="2013-03-06" version="1">MLPKSTISSFLRRTACSDPKFYYRTKTIYKNNVTIVYLFFLPSCVVIATAPPRQSQSLKHDLEPLETIEYDKLTFTREDNMYIEMKWNNQFLLIGFKDEVNMEKFCVKVNSLGVKVGKRVGKKVVGNDDGETVSYKLDNESIDHISTDTAYEVFSIGSHKNKDEISESGRDERDSRGERSSRDERSSRDERNRRGEKSSKDERGSKDDRSNKDERSKRESKSSKDGKSVKDGKSVKDGNKDGKSSKNQRESKHNNNSTRSSSSRINQRTSRKDLGAKCDLRQVYSDDHSINTEDSSGRVDLDKIQAKYDQVGHGSCSKPCKSVQEIDSLIKSQIEFGDLNFFVLTEPIYSYFCRRIMLRLCEHFDSTSRKAKNSGYNININDHFILFVRRGGRLYRLDNENDFAAAVTCLNRELDVVVRNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVC3</accession>
    <name>L7JVC3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993980">
        <property type="protein sequence ID" value="ELQ75245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1816"/>
    <dbReference type="HOGENOM" id="CLU_2980754_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVC3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="6845" checksum="08C4B31BD06F4D39" modified="2013-03-06" version="1">MVYICKISGCFCNSDKMRQLCDDYMIYDAELDLCNKEKFLIQNYSNGCKRKGRHPDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVF4</accession>
    <name>L7JVF4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVF4"/>
    <dbReference type="STRING" id="72359.L7JVF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1652"/>
    <dbReference type="HOGENOM" id="CLU_144565_1_1_1"/>
    <dbReference type="InParanoid" id="L7JVF4"/>
    <dbReference type="OMA" id="SVREYAH"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF456">
        <property type="entry name" value="E2F_DP FAMILY WINGED-HELIX DNA-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="135" mass="15988" checksum="F7625674A95CAB0E" modified="2013-03-06" version="1">MQSLTKEPKIETPSKFIIRLYAAIDDPNVTSVIWSRHETSFLILDKEHFQHHVLPMISKTTEFSGFIRQLNAYGFKKRNNIDPSVREYAHPNFIKNRFDLLTKLSRRSTGIVKIRECRLPEQHKISEREQFQAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVN7</accession>
    <name>L7JVN7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-type ATPase (P-ATPase) Superfamily</fullName>
            <ecNumber evidence="8">3.6.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.8" evidence="8"/>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVN7"/>
    <dbReference type="STRING" id="72359.L7JVN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2279"/>
    <dbReference type="HOGENOM" id="CLU_316559_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVN7"/>
    <dbReference type="OMA" id="PVCSIVF"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="811"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="901"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="7">
        <location>
            <begin position="112"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="922" mass="104240" checksum="8D489983CC369A1D" modified="2013-03-06" version="1" fragment="single">VRELTNKNCKFTNKFFKFSLKILSLMKRSFNMILETAIRPFEDKLSVFLLLLQLVSVFMVDSSIFDFFMTLLLLYLNSCLETLQNYRNDKEVNKFNNFMKIKTKKLDFNKLVLTDEIGIGDIIHLSIGDKIPSDCILIDQSTFKTTRFLKVNESILTGESIGVIKKRSKITLEDAFLFYDFCCSNLEVKNSIFMADIELTKSLDKYDERRRKRLVRILRRIRRYKRQDRRVFYGGTFVLQGTSLALVIDKSREVLKIQTSLTNITSDLTSEVKKMQNILFSSILSICIALFIYCMVLGNMSTLKICTSLAVTAIPEGLELVVRINLSVIVFQLKKKMIFVKKLVSLETLGSVDMIVLDKTGTITTNEQIIDQIFEVVPVQTNCPAGVEGKDFGGEDSTSKGAESKAQGIGFKFKPVHIKENEMFQAVCRHLSEVITVDGRTMGDPLDISMFEAVPDCKSELLFFKTFCCESMVTRGIIELENKYYEILKGAPENVLALCRSYDSENKESIKIEDKKNILRNLKERSIACAYKKLSKRYIVERVRNVTDMSSGLEDKQLKKRNYKLLGFIAFKDTLRKGVKECFNWCKANDIKVRILTGDSMLTTMNILNDIGVQGDFYSAKKYMERNLGDVNPGNDSAVELSNTVTSATLSSNNCIGEGNRNNEQFFEVIYRASPSNKHAIVKYLGRKNKILMTGDGVNDLLAIKQADVGVSLGEGSDLSKEVSDIILTDSDIKNILILLSSGRVALHNVKALLKYLISSNIGEVIAVLLAILTNREILNSKQLLFINLLTDGLPATLMCMNKGYGRGRFLFLRTILIAAYLGLTTYFIQSKTKSFLFIVIGEMLNSLNNINLGISLLISCKQNLHLVLAVFITITLLFIMTNSNAISWILEVEKVTLREFLSLALLAFPIILIDEVFKQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVQ5</accession>
    <name>L7JVQ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVQ5"/>
    <dbReference type="STRING" id="72359.L7JVQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1682"/>
    <dbReference type="HOGENOM" id="CLU_459414_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVQ5"/>
    <dbReference type="OMA" id="RTIMSNV"/>
    <dbReference type="OrthoDB" id="2189189at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="594" mass="69552" checksum="078E1EA1659F41AC" modified="2013-03-06" version="1">MKIFKGKEPDKTALCDELSILNNRLTASSYLEDRVAAINSLKEIVEKSPNEVGIYSMASVIESMQHFVHRDHFEVLSSIFRSSNGQEFQEIFLKVEKYVQILINARNKRGTDILTLLAMKDYTKVSRAFTSNEKFFTYFKKMDEKAFKLIDILIRDIFFRMKLVDNGIFESIFKMLHEHKHVKPCFSTISNLLRDSFEVQDHFYDLEWKKNLEPYCNTNPHYFFNVLESLLDTRNTNFTRMQADLNDIELANKALEMKRYDFVHVFFYNRVGLDVFMKHVDYYGLFLRCERRKELLKIYFLVNTPFEPNDIDLNNDFTCYFLACHRYKKFYGGISAAKIVSELLETSLKIKTDEQEPVQKEIDYSEDKANDKNDTSHLFDDDDEIATEEFYTKINLTSSTAIQKDVQLPEHDLIDECQHELQKINERSTFFVIGMLILLNITKTKVLLNESHINVMLALLRDDMQSTTVKGLVALLIDEHALRDNNEENLIFYMHELRKYFCGGQNVLHENVNDLFVLLITERCKALQDKIGGRVPVSLSTEHKMHENEAKKTNTSDESEGHRYKNSPKDVFRTIMSNVSSKFTTSDEEDSFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVW0</accession>
    <name>L7JVW0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">mRNA cleavage and polyadenylation factor II complex, subunit CFT1 (CPSF subunit)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVW0"/>
    <dbReference type="STRING" id="72359.L7JVW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1591"/>
    <dbReference type="HOGENOM" id="CLU_273542_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVW0"/>
    <dbReference type="OMA" id="PISCCAA"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="1">
        <location>
            <begin position="932"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1254" mass="143348" checksum="B678BA40983DEFA2" modified="2013-03-06" version="1">MSFIYKRRLFCNNIDGMCFFTPTGPQNEHRNGALPYTAMFNSSVIEIYDPVHKILEKNLFRPIKQIISCDNHLFILFADGNLSEVLYNAGNIELVSLIYIDEVGTNTFLRADGGVMYVHYDRFKFGIHVFARRAAGTLNKSAVLDNVDLTSSRRVKTGLHMFHEIDTNLNNVKDVVLIDDLIYFLYSADLNSMSVLIVDLCSFAVLRDVSVDSTAFKLYRLNDTHVVVLSERTVYFLWVDSVVFTYCVPFDELADQNGTAGAFEGARLFNTAEAAVNDSIFIFNGDHKIYRLHICYAGQHIQSVSTGVQRSFHQYESIRRVFEANHFLFLVLEDRTALLLEPQFSAVPKIKKNVPLSEVDDNIDLYNTRVQIDQPAEAEETANDNIDLYNTRVDQPAEDTANDNIDLYNTRVDQPAEAEEVERQIKTYSLIKTHHSFGNIKYVFECDTGTNGEYLIVTDRLIQYFDVFTFKFTRNHRIGGYKQLMKANDLFVLTNETSSSFFRWIDGKIVKYDGLLKDNQKERSVEVVMDEYVKGGDEYVKGGDECVKGKDEHLGGDEHLGKDEKDECVKGRDEHPQINKEHEFENKRAKIARAVQAKTENTEYITDQETLALFYFQNRLFQVTRAFINVLNERKMPINAETAKENGTLLFVKTGGSLKAYPLVDLINGTMTCALSFENVECFSANGPLLLLCDSLDGVSRLQLFRGEEMLFCTRLYDFCDILNNGGAENELDATAADAFRIDECLVYQNNDVFSVLLKSAHVIALYEGFARADHLPYFVKRRNLISFYRHALHYTRNFVFIKNNFVILTCDNRVQRTTNSFECVVEDADAIYGISKRNIVEFSANPAGCVQRVHDIKNIDRIIKDETNGVYVLTFLPRAFETSSTCNAKDNEDTPCEERQELVTCNAKDNEDTPCEERQELVMCTLSLARLSIFRLPKNELVTDLKIMSLCDSNGDHNDFVVVVLSQRTSNEILRGRILVFEVIDVISDTADRKTKKALKLLGSERTKGPISCCAAVRGRIAVSLATRLMVYEFDRNTGIVAIAFYDLYMYAVSLAVIKNYIVVGDIMMGLHFVYFQSEPVKLHLLSKSGRVANLGSLDFFNAGDRLFITGIDKTGEVQIFSFSPGNLYSNEGEKLVKRQQFETYAHFQSIRTNTYRSYASFFSSQNFFVTLSYTQKDYGKIHDVLKCYREIKSFWGVSLRYQHQEVCYKKCVHTDLLLNFFNEPVKYQKDVCGRVGHDYEEILHLIEDFLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVX2</accession>
    <name>L7JVX2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVX2"/>
    <dbReference type="FunCoup" id="L7JVX2">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1893"/>
    <dbReference type="HOGENOM" id="CLU_093240_0_1_1"/>
    <dbReference type="InParanoid" id="L7JVX2"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="149" mass="17066" checksum="0E39A04686C6D152" modified="2013-03-06" version="1">MVSTTVGSWNRSFITQNIFDPSKKKMKLNKNISSSRRKQRKRHFNAQSTDLTKQMTAPLSKALKEELGIKRIPVRPNDTVMVRVGKYKKTEGKVVRVNRVARKICIEGVSITKKDGAVRYLGVHPSNLSIVRLSMEKDRNRMIEKIKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVX8</accession>
    <name>L7JVX8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1447"/>
    <dbReference type="HOGENOM" id="CLU_1687150_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVX8"/>
    <dbReference type="OMA" id="PYYCDIE"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18736" checksum="3D332BBF40EAA91F" modified="2013-03-06" version="1">MVEHNFRKDYVFFNKTIFTEHNVPLPCSDDERIHFYNENTKFHTSIGSGELNNTLKYSSPTGKLFLTSYRIVYRPAEINEYFSSFHCGLNSIISVFDDHFQFNIDDVFLSSVYISFIDTQKQVFYGLLKELLSRDTVDSDYDENTADLPYYCDIEDNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW23</accession>
    <name>L7JW23_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Ubiquitin, Ubiquitin subgroup protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW23"/>
    <dbReference type="STRING" id="72359.L7JW23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1563"/>
    <dbReference type="HOGENOM" id="CLU_010412_6_3_1"/>
    <dbReference type="InParanoid" id="L7JW23"/>
    <dbReference type="OMA" id="GGRGCYP"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="78" mass="8797" checksum="E4EAB11A352B2006" modified="2013-03-06" version="1">MQIFVKTLTGKTITLEVEPSDTICDVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNVQKESTLHLVLRLRGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWK4</accession>
    <name>L7JWK4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993987">
        <property type="protein sequence ID" value="ELQ75127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1928"/>
    <dbReference type="HOGENOM" id="CLU_3377389_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWK4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="34" mass="3854" checksum="C450125398F5F273" modified="2013-03-06" version="1">MNGSLYDSFYESTVVEATVSVQRARRVCLVCEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWM3</accession>
    <name>L7JWM3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993986">
        <property type="protein sequence ID" value="ELQ75142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1927"/>
    <dbReference type="HOGENOM" id="CLU_1280456_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWM3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="216" mass="24692" checksum="889D104114DE7D9D" modified="2013-03-06" version="1" fragment="single">VKENLVKNLTGQYKKFTTQANSIIKNHVSMLTLGKDKFAADFTSTGKIRFYVSKKDISASPEQIEESKFTPWFNFDSKGIINIYGWHKTLHEFVKELYEAKGFSLKDFDPAYVYFESTGDINFTPSPRDHFPFISYGYIALKSLLSDVHGCTQWTTDDNDPHGKYNFTSSGYIGFGKSDLPRLSKLSKDLVPSGHSMNTVWYSFVSWGIMNMITDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWM8</accession>
    <name>L7JWM8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_1201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWM8"/>
    <dbReference type="FunCoup" id="L7JWM8">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1201"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_10_1"/>
    <dbReference type="InParanoid" id="L7JWM8"/>
    <dbReference type="OMA" id="DCCLYPR"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="140"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ75829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="441" mass="51539" checksum="E16B662425B487C0" modified="2013-03-06" version="1">MTESREFDKSEYKKVPLKEINKSHISQKIHSFGWVYNRRNAGQVGCFINIFAQYKILKCLYPHKIDTDNLTRWTSMDFYGVVKENFTKDGAEVEFHIDHYDVRKIAPSFPVNKDTQAFVLLEKGHLALRMPERMFFLKARSHMLRCFREFFYEKEFTEITPPTLVQTQVEGGSTLFKLNYFGKEAYLTQSSQLYLETVVPVAMKAYCIASSYRAEKSNTTRHLTEYTHVEAELADICFEDLLNVIEDMVYTVVTDFYEKMKGEILELYPYYEFFEFKRPFKRISYEDAIKYFNDVGYKKDNGLDFVSGDDIPDAAEVFLVKSYADNTPLFLTNFETAAKPFYMRTTADPKYTESTDLLFPNIGEILGGSMRKEDYQELVDGLRSEGIDPKPYYWYTDMAQYGPCSHGGFGLGFERLLVGLMRWKNVVKGCLYPRFVTRCYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWQ4</accession>
    <name>L7JWQ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1536"/>
    <dbReference type="HOGENOM" id="CLU_2086473_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWQ4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="117" mass="13106" checksum="4787A6D49A22690F" modified="2013-03-06" version="1">MQTMPQGSTVDFNATYCHNNTNQEQVVFEHVPCANLMPGFPPTTNQWKRKINYNFSYPSPSKQVKTESSRSEILIALLNQSDEDLNPYVPSNKDNPSTSNDEEEASSQPAPLPTNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWR3</accession>
    <name>L7JWR3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein contaning Peptidase C65, otubain</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JH993902">
        <property type="protein sequence ID" value="ELQ75923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWR3"/>
    <dbReference type="STRING" id="72359.L7JWR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1110"/>
    <dbReference type="HOGENOM" id="CLU_1462332_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWR3"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="91"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="20788" checksum="294F9B2584C8A029" modified="2013-03-06" version="1">MQNEITTSDSLIGVNLQINSGNGVSTTIVMSDWSASTKSVNTDTITPQAHDSNNEIKDQRIHIYQCSSADYFVDESVEIRDKDSMFEMVDLNSLTMFLKLLVSTEMKLNEEFYAPFLSKSVSAYVSESVEPFYKDTDYVDILAFSRMLGIKVLVYTIEGHCNEIGTGSVELGILHTFDHFEPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWR9</accession>
    <name>L7JWR9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1553"/>
    <dbReference type="HOGENOM" id="CLU_2869241_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWR9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="64" mass="7670" checksum="50425F2BA2A43E0A" modified="2013-03-06" version="1">MLVRKVKRYCSRLYLRYCAEFGLSLMEEWEITIVNFCVLILGYSFVEHVCKMVLKIYWAGIKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWS4</accession>
    <name>L7JWS4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1099"/>
    <dbReference type="HOGENOM" id="CLU_1526230_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWS4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="176" mass="20038" checksum="3FC38A222F14C3CB" modified="2013-03-06" version="1">MFFLHFLTIRSIFEKRDDGTFVMTLKDIDDAGGIDGLLGKLKESGLLGFELPSRNETKKSELSTEEAAKKDGDKSGLTAIGAGAKGGEAQSGAESKQSGQAEKQEKSKEKDTQRQDKAEQQQKKQTDKKEAEEKKKEKGAEAEKKKSNRKKRQKQRRKRKMPRLRRRRSNRKKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWT6</accession>
    <name>L7JWT6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">THOM_1288</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWT6"/>
    <dbReference type="FunCoup" id="L7JWT6">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1288"/>
    <dbReference type="HOGENOM" id="CLU_030988_7_1_1"/>
    <dbReference type="InParanoid" id="L7JWT6"/>
    <dbReference type="OMA" id="GMHEFNV"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="14">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ELQ75760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="177" mass="20327" checksum="77DAD3308866DA5E" modified="2013-03-06" version="1">MSAHRMRKSINRLETEIYKLRAKGYLKKISESNDELIVELRGPKDTPFHNGLLTVSIVLPLDYPFKSPSIGFVGKIFHPNIDESSGSVCLDVLNQVWTPLYDLQTIVEVFIPQLLAYPNAMDPLNTKAAQMYLNDRDMYNKVAREYVTKYSNEINREREDNSLSYSSSDLEFDAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWX0</accession>
    <name>L7JWX0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1840"/>
    <dbReference type="HOGENOM" id="CLU_1220491_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWX0"/>
    <dbReference type="OMA" id="ETYLWEI"/>
    <dbReference type="OrthoDB" id="10348495at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978864" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25564" checksum="8F079ABE657328C6" modified="2013-03-06" version="1">MLIVFFVLLKFLAASLTDSDKAIVLKTDSSRILVSIGKTIRLRTRNLPDRRDDEGVFRFIEAQNGYYIKFKDGLLCKSGKDSAGVTGCQSEADKYTVWKVNMAGESGAQIETTGNLCLLPTGLDNREKTKGRYMQAKPCTDETYLWEIVDLEYPNEEFQANKGDMMVGNTDWDGRNVDIERIHHMYDAHPLPVEIFPKENRHIITSRSPDAFHVNEHSHVAFENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWX2</accession>
    <name>L7JWX2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993893">
        <property type="protein sequence ID" value="ELQ75978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1053"/>
    <dbReference type="HOGENOM" id="CLU_2777701_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWX2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="69" mass="8082" checksum="59626AB9C012D570" modified="2013-03-06" version="1">MIVSESAIKWILCFRSKTFEHAQDVLICNNIKETHLSDVIMKISRPTTNNYKNFSVEEYDILEDPLHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX08</accession>
    <name>L7JX08_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX08"/>
    <dbReference type="STRING" id="72359.L7JX08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1758"/>
    <dbReference type="HOGENOM" id="CLU_1954067_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX08"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="39"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="129" mass="14754" checksum="E37E39C7FFF03273" modified="2013-03-06" version="1" fragment="single">VGDRDSRRDNDRFRSYERDRGDMRGGNRGMNPPSPPPSKVLGIFGIPVSIAHEELVDFLKYHIPSIPYQSIHLVKDRQTNLSRGFAFVYFDTIEDSTLAKDALVNKEIHNKRVRVDFAIGDGQRPPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX74</accession>
    <name>L7JX74_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX74"/>
    <dbReference type="STRING" id="72359.L7JX74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1027"/>
    <dbReference type="HOGENOM" id="CLU_418614_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX74"/>
    <dbReference type="OMA" id="YDIDMFG"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="448"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="621" mass="73358" checksum="CAA41457C1C02CF0" modified="2013-03-06" version="1">MSFLRYKNEVLNELAHPDGINEEAAQKIINKILKMDKNAEDYDFHIQLGFEIALKMKKRTKILIALWERGSFQIRKAIFEILRDEKYDSKELMASFEVIKFRLGYCIDKERLKALLTQINAKLRNKIVKILEFYGFYTKEFVYRPQKERVWNYWDLCHESVYEIDDVFLKEVEPSNSTKKVKIVSDINEITIKVLDSIGNIREMVYFHTADEPESIEMIKRGKYAELVADSKCRYNTESYAYFCLGDYHNTRKVLLSGLKHAENDEQYSDYVDKLLLLDRVAHISGVHPNILVKFNNDWHRNRTERQIRFRDCHNKYRDFKNFITMRFNDFRARMVDFNEYVYLFYCKDGRLTIYDCKNNVKTRTSVEISDKILQLRTLLNRSKETVARKVTSPESIRKWWIDRYNIDNDLEKLVSFKLNYKFEGEITICLDEDLTEFPFERTCELRKCNVFRLSCSEYVFRDQKHLVLKKLTISCIAGGINLRKTEQRISKFTEKHGIDSIVSENTEIFAFFGHGSGIKHIQMYTPSVMLLFGCSSVRLIERQNFQKVGVPVKYLNTSQIILGCLWDVTDYDIDMFGTCLIELISNGETIHKAIDKAKLRMRLKWLNGASIVVYGRLSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXB6</accession>
    <name>L7JXB6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1690"/>
    <dbReference type="HOGENOM" id="CLU_498929_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXB6"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="233"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="546" mass="63397" checksum="2D2C7A16C100F30C" modified="2013-03-06" version="1">MSNQLQKIGINTYKNKVNYMIKHLPSDFIVQEVHDHDDICDDESDHLDVSFLKQFLDDEIVKTIVELKEIEDETDTRELLSEFEVPKKEDRTLLHRALKGNPLIESEYVSTKFRIYKSTMKGTFSFVLRKENEDTVEACMRISRELNVPFKNIGFAGNKDRRAITYQRISISDVYYKDVKHLHCVRRERGHLKLGRFKGNRFIILVRPKEDPSETGTCSLDDAIRKMDVNTKKFPNFFGIQRFGRNLDNHLVGKLLHQKKYEDAINLIMMVKESDGDYVKEAKHSFYNKEYDQAYAQFPRNCLAEKSICRNISKGYRRAIFSIKEKIRILYLHAYQSYIFNQELSKLLTEKYEGTEELILQGSKVKRKAFTELKDFDYEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVYTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXD5</accession>
    <name>L7JXD5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA carboxylase</fullName>
            <ecNumber evidence="9">6.3.4.14</ecNumber>
            <ecNumber evidence="9">6.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.3.4.14" evidence="9"/>
    <dbReference type="EC" id="6.4.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1655"/>
    <dbReference type="HOGENOM" id="CLU_344235_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXD5"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0092">Biotin</keyword>
    <keyword evidence="1 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="8">
        <location>
            <begin position="4"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="118"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="779"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="822" mass="92652" checksum="27D7E35D8578BDE8" modified="2013-03-06" version="1" fragment="single">MSTTTTKILIANNSLAATKFIISLTAHNITFLGMVTTHDLHSNQLYVTYLDRYVIVRDYGVDEILRAAAYFQPDYVWPGWGHSSENYVLPMMLRQHGYQFIGPDEHAMRVLGDKIMSNRFAESRGVPCIPYTTDEDEFVRFYRAHAPVLIKSSDSGGGKGIEVVETEEQLVRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSPNPKKCTPVFNKLPIQTETTTDNKSEYSQSTAQMTVLTDLTSTPSTRNDVFMTKIIKNARHIELQMLRDNHNNTVLLGTRDCTLQRRHQKIIEEGPAMLSPTMYERMKRCAEVLLHDAGYVGVATVEFLVARPYFYFLEVNTRIQVEHPVTEFNAGVNIPELQLGVAMDKNMGWLKEHVRKCYVDWDINRSDKGCDDCSVSTDHESNDHEGIDHEGKSMNGGNYNTNVDNTSSYCQSNSNHVIAARITAEDCQFNPQTGRVSVAYLPTPNTLAYFSVLNGQITEQNDSQFGHVFAYGRHRKEAIANLITALMNIKITGIDSPVPRVLDILRSRFFADYDFYTDTLEKLSFRSVNVDDIAYFSVAYFLVSGNERVSFVYNDECFSTRCYVVSEYEVLVELNGTYYKVRMANDKSSDRNDGNDRGGDNSSDKIDGNIINKIDGKGSKKEKIFSTPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXI7</accession>
    <name>L7JXI7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993956">
        <property type="protein sequence ID" value="ELQ75467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1588"/>
    <dbReference type="HOGENOM" id="CLU_2374266_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXI7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="95" mass="11204" checksum="6C89DB8085CEAE3F" modified="2013-03-06" version="1">MNTYSIGNRQLRLPDCSRSCRMKASEHSNVNLKTMSQRIKNFKKNSDGTGKEFCKRYVTIFCSKRRMENHVTSTEHIEVNYERNGTIIRLEIRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXL1</accession>
    <name>L7JXL1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1247"/>
    <dbReference type="HOGENOM" id="CLU_1058406_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXL1"/>
    <dbReference type="OMA" id="FTICRID"/>
    <dbReference type="OrthoDB" id="10249733at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30955" checksum="50B3AC725011E975" modified="2013-03-06" version="1">MSKNYIFKNINRNYFQNHMMKVDRQIYIISAVFALVLFTVVILSLYSSINAADRAYTNFSGLIDDQLMEFSESDFVEGRVNSKFCSFMSMKLANNDNTISLMYDFCDFKCEDELENWLKNISGEPQYKKFFEAFLKRPSDESKEEIPHDNLKQQKVLPQQTFWVRTASKLFRNFTICKIDRVIDFVLRDTPSSERFNVIIMNYNDEKQYNVFKIQASSNNYELKLIDTLKLKLEGRDAFMIYSDILLKLALAAKSEEKQVQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-05-03" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXL7</accession>
    <name>L7JXL7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1542"/>
    <dbReference type="HOGENOM" id="CLU_182435_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXL7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="93" mass="11023" checksum="3104E2EC4F2AEA16" modified="2013-03-06" version="1">MFFLIKKPAWLDIAKTREMERARRYEIGMKGSRTNTKFIKKDDKYYLKVGDKWLEMKGVGMKELMVVKDGVCVGVVDEKWLLGMVKMDEQQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXR4</accession>
    <name>L7JXR4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor TFIID, subunit TAF9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXR4"/>
    <dbReference type="FunCoup" id="L7JXR4">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0758"/>
    <dbReference type="HOGENOM" id="CLU_068315_3_1_1"/>
    <dbReference type="InParanoid" id="L7JXR4"/>
    <dbReference type="OMA" id="AYMNDIG"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="128" mass="14541" checksum="B12DE1788CB53DA2" modified="2013-03-06" version="1">MAENSAPRDTKVISLILRSLGIEECEPKAILQIHEFIYKYATDVMKDASQYAEMVDRQVITEKDIKLALQTKVGRYFVPPPPRAYMNDIGTMVNSRPIRAYGEGANKLPTGKNTLLNFESRLMDDNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXT0</accession>
    <name>L7JXT0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0774"/>
    <dbReference type="HOGENOM" id="CLU_1288889_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXT0"/>
    <dbReference type="OMA" id="GFVPCSF"/>
    <dbReference type="OrthoDB" id="2190706at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="224" mass="26406" checksum="7C8B4C932CB47B7A" modified="2013-03-06" version="1">MTIFCYPHMHFEDEIEYFGFVPCSFLQELCLTLEETITGTINSTGLSSTKKNLLCSYVLSEFRKNFLIFENFSLHQIFTFPKDFSYERKITDLVVEDDVDGMIDELMKLKDEHEFYKNEVQRHKRIIANKEIEIAQMTSFLENAEVNDLLSNTEFLKKLFIETKKVVGEKAYAISGKLNTKFNELMENKDIKNEMKKKEINELYRIGTLEDIKTFRDSMLARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXY5</accession>
    <name>L7JXY5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor MBF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993903">
        <property type="protein sequence ID" value="ELQ75921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1119"/>
    <dbReference type="HOGENOM" id="CLU_2401336_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXY5"/>
    <dbReference type="OMA" id="RENMKMT"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="93" mass="10507" checksum="BB51AEDFE860B1FD" modified="2013-03-06" version="1">MSDQDTKPLIIKKYVKKSVKQEEEVSRLVKLDVKGTKIMVHARENMKMTQKDLAGKINKPVSVVRDIEKGEEVERSVVEMVEKTLGVKVLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXZ6</accession>
    <name>L7JXZ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXZ6"/>
    <dbReference type="STRING" id="72359.L7JXZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0749"/>
    <dbReference type="HOGENOM" id="CLU_497993_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXZ6"/>
    <dbReference type="OrthoDB" id="2189670at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="547" mass="63252" checksum="444DD84C9DA1C1C9" modified="2013-03-06" version="1">MRRKRITLSVRKKIKENKNTSCTVGLRAQNNKKRLLAQANTGEQGTEKHVEQTAGDIRIVVQDGVLNCQVAENDENRDECKRKRGRIELSLGKRKESVNRDNKENLNDGGNARNLQLTNKDALVNEETCRSANQQVNAEQNVCTGAAFSEKPNCTRRSKMCVKLPNAGNTRVRSVKTSVRPVVRIKSRTNSTKNNIFGNRTVGLRIKNVKQELENEEKLAVRTAERALKKEKLNGPAGKTAVGRRNGRLKDGIAEQQNKTENGSNQNDMPNKTSGNTSEELQRGQINVGTEWSADKNALGELLPRTIIEDVIEKGSDFDEVARKEIKEQFADQMQTIARIAREEHHALLIFIDPYIESVIRMFIKTWYLKEHESVRFVDVDHARNETLYYELEDCTNFTFLITRNAMAIEQMERRIRSRFNNVKIFFGYLRGCKMPVDAIRNVYLSYKYEIPRCNFYGFLKLFKPLHIAIILCWIKKGLNRNKLVHTMKEFLFKVNEMKNVSDKEIVDAFYEVESTKIVRRNKINGDYYKLIEYVKKEMPFYLKRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY02</accession>
    <name>L7JY02_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0862"/>
    <dbReference type="HOGENOM" id="CLU_3242456_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY02"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="43" mass="5030" checksum="E8773C6197A24D50" modified="2013-03-06" version="1">MTTKIRKRLNYSKNGSNIEQARFEGITSQWYTECAISSVYVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY08</accession>
    <name>L7JY08_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993863">
        <property type="protein sequence ID" value="ELQ76175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0848"/>
    <dbReference type="HOGENOM" id="CLU_534402_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY08"/>
    <dbReference type="OMA" id="KEQFIFA"/>
    <dbReference type="OrthoDB" id="2192420at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="510" mass="57608" checksum="D9E1D0B9F25CF932" modified="2013-03-06" version="1">MFVLPFFLSINTLRILRLRTEPDLLVGLSDDKLLNLELKPVNRKELNSNGVLVKNRVVYFYRARLYYSMGIAADDITVKGHKADISIDKKMERMAAFKHTKVDFFGSNKVDGDSKGTMKDSANDKPAPYSPFNFSFVGAKTEQKEAPRDDGGARAADSASFFASMNGKKQGQGKLANGSKRSHEGMDTSSMNGNPLVTENFYNRQPAYAAELSMASYTGKANGNPETGTFTHVTDSVVRGNAGSFADPRQRTPLPDPRQKDASPDPYQRGPPDPYQRGPPDPYQRGPPDQYQRGPSDPYPRDSTIPPPLQYQSDQNMPIDLFERKYQPPSSPFNHHFPDTPEPSNLQTHHTKSHRNSHTVSFHIESDSSMETEETNQIHQACIYEVSENHFQLKNDNLCITYFKEQFIFAPCTKSKSQHFTLVDAKKLIENEESESEEQLLLKRRKVGVENDRPKEVVSERSVAPINFKIAKDEPKEKKVVVTKTKDSDNFIEQLKSTFDEKAIKEIINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY81</accession>
    <name>L7JY81_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_0771</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY81"/>
    <dbReference type="FunCoup" id="L7JY81">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0771"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="L7JY81"/>
    <dbReference type="OMA" id="IRQRHWF"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ76260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="198" mass="22515" checksum="5B66F3A38F77F63C" modified="2013-03-06" version="1">MGSVIAAFTNLFNTRTPYSICMIGLDAAGKTTILYQMKLKNTVPTVPTIGFNVEKFQVNNVEFSCWDIGGQDKIRPVWCKYVELSDGMVFVVDIFDEDRWSEAGEALRSILENYKNKPVLILANKADDPNDPELDDRKEKMLKVFNIENVCDLWECKTVSGIVSATDSNPLLRLLPAFEWMVDSLEKTHTMRKRRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY87</accession>
    <name>L7JY87_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY87"/>
    <dbReference type="FunCoup" id="L7JY87">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0629"/>
    <dbReference type="HOGENOM" id="CLU_112958_2_2_1"/>
    <dbReference type="InParanoid" id="L7JY87"/>
    <dbReference type="OMA" id="MKRIQQG"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="137" mass="15635" checksum="52208C7F83387D9B" modified="2013-03-06" version="1" fragment="single">VVFSNSKGQIKIKSVKKAAKQIVEKYYVYLNEDFYHNKKVVSDFTEIQTKKTLNKVTGYVTHLVKLVLKGTSKGLYIKKHEEDREKKEGYLPKVSFLDSNRVEVDSVTMEMVNAYGFEGNFVEIGSKMNGAEQAEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY92</accession>
    <name>L7JY92_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0724"/>
    <dbReference type="HOGENOM" id="CLU_2591472_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY92"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="80" mass="9364" checksum="1C6EFDDBAA2DB8B9" modified="2013-03-06" version="1">MLDHLKLKAIQPEALHVDMDELRDKDLTHHNTLKTRLRNNKIAIILHSPHLYKHLSAKGICELKDQLEFVDESFEQEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYA1</accession>
    <name>L7JYA1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1374"/>
    <dbReference type="HOGENOM" id="CLU_3126085_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYA1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="5573" checksum="E64C925FE5DF43DE" modified="2013-03-06" version="1">MVGPVDQMSKMNEKLTMVGPVDQMSKMNEKLTMVTSNRPEKCVKVNSGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYA7</accession>
    <name>L7JYA7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0740"/>
    <dbReference type="HOGENOM" id="CLU_1603907_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYA7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="166" mass="19076" checksum="70A4EE8C4826DCAF" modified="2013-03-06" version="1">MHETNRAEKYSPTYENASNKDEYAKKYQDDVGYETNSEYDGKYDKTRLVVKNTPEKNLTFSTNNHFSENKRFSENKRFEAANRFEDESHFEGSSHYNESTNYDTSGYKKENLHEDNISNASTFNALSSEAGGGGSSSQNTRKVFFLISKKRILAINLKLSLLTSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYB9</accession>
    <name>L7JYB9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1394"/>
    <dbReference type="HOGENOM" id="CLU_2711826_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYB9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="8157" checksum="B67A526BB75CA3AF" modified="2013-03-06" version="1" fragment="single">VHLIVMSIGTVFIPMRNSMKSGTRYIKCTARSSVGCLSGNGAKGFCPVIGSLKFANFSMRGEQFRVMYDKMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYC0</accession>
    <name>L7JYC0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA+-type ATPase</fullName>
            <ecNumber evidence="6">3.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JH993848">
        <property type="protein sequence ID" value="ELQ76429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYC0"/>
    <dbReference type="FunCoup" id="L7JYC0">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0590"/>
    <dbReference type="HOGENOM" id="CLU_000688_21_0_1"/>
    <dbReference type="InParanoid" id="L7JYC0"/>
    <dbReference type="OMA" id="LCQEAIW"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="172"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="410" mass="46495" checksum="D30491DB7920E6E9" modified="2013-03-06" version="1">MLDKYFEILKKLEENDKMPFAFIIPKDDNKCVREELKDLMLEYLKSGKVDKELISNFMFPMETDIDKIGSLLTDKEIPGDFFDDTCATERTERKPCEFTTAKSQPINKEKGSTSTSNLEDHLISKIESEILTTTLNTSWDDIAGLENAKRIIKEIVVWPMLRPDLFTGLRGPPKGILLFGPPGTGKTLIGKCIASQIKATFFSISASSLASKWVGEGEKLVRALFHVAKQKEPSVIFIDEIDSLLSQRTDNENESARKIKTEFLVQFDGAGCTNKERILIIGATNRPHEIDEAARRRLVKRIYVPLPEEQARIQMIRSLMKEFKFNLTDDDYSEIGAATEGYSGSDMFNLCREAAMEPLREIDDISKAVEGSTREILKSDFLKALKQIRKSVSKDDLEAFMKWNDDYGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYH9</accession>
    <name>L7JYH9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1253"/>
    <dbReference type="HOGENOM" id="CLU_1490012_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYH9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="21400" checksum="8F2A2E41F708E99D" modified="2013-03-06" version="1">MIVSCTFDHITDQPDVVRVTSTNAQPYVPRYTYYFPWCIRSPTHIPDYFVWRSNLILQWCDALEVSFIFMTSIEYRVDELSPLICIVKKIKSTLQFIGSQINTRAWRMLNLNNILFMMESGIVALNKIKNAVLSLYTISLAYCCFYELCEAYFLQQILNSTVKIIHDLNYYNCRYTTERFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYL7</accession>
    <name>L7JYL7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0897"/>
    <dbReference type="HOGENOM" id="CLU_2998126_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYL7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6431" checksum="5B133C72053BE8E7" modified="2013-03-06" version="1">MVIFYEVLEELCNLTKLSYPNVNLINLEDASLAGTVKVLAYELSKQSFFGNIIDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYN4</accession>
    <name>L7JYN4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993835">
        <property type="protein sequence ID" value="ELQ76573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYN4"/>
    <dbReference type="FunCoup" id="L7JYN4">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0442"/>
    <dbReference type="HOGENOM" id="CLU_017172_3_0_1"/>
    <dbReference type="InParanoid" id="L7JYN4"/>
    <dbReference type="OMA" id="MCANCAP"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="171"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="9">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="495" mass="57415" checksum="2A74DB2BCD1380AF" modified="2013-03-06" version="1" fragment="single">VCAPLTMVDVSIMTATKFHQVALEDDKKIGESLITIFGCEIKLFYDYELTKSIDTEQLPTSLELPDIIYSDYEEEIVAQNKKSTGNKDIFCNHGDNAMCVNCAPVSPWDPKLLRERGIKYLSFGAFKEKNQRIERLTYRNECKHAQNVKCTRCMERTIALKQQNYRMIDHVEIDHSKTVDNFISFWRGTGRNRFGFLLGKIKDYERVPLGKTAVVSAIYDPLQENFPDGFVVHEKECSKIRALLDYIGLDVIGMIYTDLNHKRDYLLSCTEIDAMAKFQNENMFADDDGKVFNSRFVSVVVRNNDAGVELEAYSVSEQGMVLIDENIIKPCTDKQTFVSTHPIIYLEKNEYDLVVEKNTMRVPVEYLIVDIPHGFSEKSMFPCGTYFNPEWGKMKVAKYFTDYSLEKFQNFNVLLYFFQKFNGSDRSLNADMKLLVDAVLGRVRIEKFLQTFTFLKFTDSIESHRKEEWDCKICTYRNLDGTDRCEMCETQRNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYS5</accession>
    <name>L7JYS5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Endonuclease/exonuclease/phosphatase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993905">
        <property type="protein sequence ID" value="ELQ75907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYS5"/>
    <dbReference type="STRING" id="72359.L7JYS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1130"/>
    <dbReference type="HOGENOM" id="CLU_075869_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYS5"/>
    <dbReference type="OMA" id="GHYENHE"/>
    <dbReference type="OrthoDB" id="2190927at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979152" evidence="2">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="341" mass="38314" checksum="8D181EC90E8FB33B" modified="2013-03-06" version="1">MHKLLSFIVLISCAEIAHKPAFPGKAGGVNKPATGMPESIERPSKPPRTGLYYETKWDPLLSSKTSGKNMQDVLEMGGHYENHEITTPPSDRYGDLSVFTLNIATEINLITINQETASFIHEVLDHAHPAVFVLQGVREPVLARIKKLENHHYGIITDDVFTKDPLSSAHYYFPIIIDKHMIRPIKSGYFRNQKGQVYASYAVLVDTRKNKRFTVVNLDLYSTFKETVEAQFANIVSDIKGDMSISKEPVIFAGGIGSPSSEIQKLLQSGYKNLIDLDPNNKELDKTTVHGRVEHSDNVQRDFIVLRDPATVLDLNYARILNDKLKIAEHYPLHAILSYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ58</accession>
    <name>L7JZ58_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0326"/>
    <dbReference type="HOGENOM" id="CLU_2098671_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ58"/>
    <dbReference type="OMA" id="FDMFFRP"/>
    <dbReference type="OrthoDB" id="10386270at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978904" evidence="1">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="14370" checksum="4C379426C3C851BE" modified="2013-03-06" version="1">MLTTFLFIRLVMSLASSVYKGEGKYYRGRYISLKDMRSKINVYDPDAKDEYNEDHTKKNVIMDNEAFDMFFRPDERKQDENEHVLTEEELKTKQKMKEFEDEKNTYLVFLRRKYGIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZD2</accession>
    <name>L7JZD2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZD2"/>
    <dbReference type="FunCoup" id="L7JZD2">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0207"/>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="InParanoid" id="L7JZD2"/>
    <dbReference type="OMA" id="TFIYGYC"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="201" mass="22327" checksum="C40C2EBA04843D66" modified="2013-03-06" version="1">MPEYEMTGTTIVAMKFEGGVIMAADSRTSMGNYVVNRVSNKLTKLAPKIYCCRSGRSSHTQAVAEYVASRTNLIAYTNEREPLVRDAANLIRAVVYYNPMLTASIIVAGYDEEDKGSVYSINLGGSLLKREWAMGGSGSAFLYGYCDSMYRSDMSFEEKFELTKKLVQLAIKRDNMSGGCIRMTVIRREGVENIFIPGNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZD3</accession>
    <name>L7JZD3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_0598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZD3"/>
    <dbReference type="FunCoup" id="L7JZD3">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0598"/>
    <dbReference type="HOGENOM" id="CLU_1048568_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZD3"/>
    <dbReference type="OMA" id="GYTNFRE"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ76411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="219" mass="26087" checksum="168DA116A992743E" modified="2013-03-06" version="1">MIVYDKKYTLTYKGYDHLALAYFKKKGLSRIIDQIDIGKESDIYLGEMNGMLVAIKMYRIGRTSYRRTENRDNIKMDMYKRSMMYCQREYKILRSLTSENIAMPVGCNRHVLITRYYECKPLVRTRLDDLDYFYNKLMNLVVDLYSMGYVHGDFNEYNVLINDKQIVLVDFPQCVPTTDPRAGEYLRKDVQCVKEYFERKYRYINERDVIAEIGAGCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZM4</accession>
    <name>L7JZM4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993863">
        <property type="protein sequence ID" value="ELQ76177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0850"/>
    <dbReference type="HOGENOM" id="CLU_1571799_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZM4"/>
    <dbReference type="OMA" id="ALYLHYM"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="208" mass="21999" checksum="A057BDE92748E143" modified="2013-03-06" version="1" fragment="single">VLFVYTPTKSINTALYLHYMNRLTIIIICIVVATVILLIVVPTIIYYCVVDDEEGESSSVSVSKVSGGSDSSKESSWFGGQDEDETEDEPVDEEGANGTQSGEVPHYRLYVTQSGEGQAANPATDETGEGDEEEGAANEEEGAGDEKEEGAGDEKKGGADEEEEGAGDEKEEGAAEEEGAEEECAEEEGAGDEKEEGAGQTNQPEQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZN9</accession>
    <name>L7JZN9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Arrestin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0072"/>
    <dbReference type="HOGENOM" id="CLU_1220434_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZN9"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="227" mass="27177" checksum="7C4D44E0C45E7A42" modified="2013-03-06" version="1">MQKNCNFKITLDKAYFLTNEIVSGRIHLELLEPINLHTIYVHFYKKFECEFDTPRNDSSFTKKRCRIDRTVYNKEVTVYESFRHVNKLGSGYHVFPFKITLRSNDSGTCNLSQYVDNVYVEANNYYGINAFLKVEGVFKPVLTDSVRVEIRTYHQKQKNHRYGKYYIMPVSDVHQFDCYRPHRQEPIRHDRYNCVLHACFKQCVWHQRRKITAVLPSCTQGKEQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZP6</accession>
    <name>L7JZP6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">THOM_0219</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZP6"/>
    <dbReference type="FunCoup" id="L7JZP6">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0219"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="L7JZP6"/>
    <dbReference type="OMA" id="ESRFPEW"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035175">
        <property type="term" value="F:histone H3S10 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051316">
        <property type="term" value="P:attachment of meiotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120110">
        <property type="term" value="P:interphase mitotic telomere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090267">
        <property type="term" value="P:positive regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903380">
        <property type="term" value="P:positive regulation of mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905824">
        <property type="term" value="P:positive regulation of mitotic sister chromatid arm separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140429">
        <property type="term" value="P:positive regulation of mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904967">
        <property type="term" value="P:regulation of spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ELQ76780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="270" mass="31710" checksum="BAE01655516D2690" modified="2013-03-06" version="1">MKNWTLDDFELGAPLGAGQFGQVWLVREKVRNYILALKIIPKSIVEKTDSYRQLRRELEIHTKLRSPYILRCYGHFHDKNNIYLVLEYASNGELFHHLVEKGKFDEKTAANYIYQVLHAVRTMHSHKVIHRDLKPENILIGCDNKLRIADFGWSVCDVDQKRGTFCGTQEYLCPEIINKNQYNNKVDMWCIGILTYELLVGNTPFEAPDRTTRDAYRKIRNLEYDLPKFLSENAQRFIARLLVAESEKRPDVNEMLNDPWITENVYVNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZT8</accession>
    <name>L7JZT8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">20S proteasome, regulatory subunit beta type PSMB4/PRE4</fullName>
            <ecNumber evidence="2">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="2"/>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZT8"/>
    <dbReference type="FunCoup" id="L7JZT8">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0762"/>
    <dbReference type="HOGENOM" id="CLU_072435_1_0_1"/>
    <dbReference type="InParanoid" id="L7JZT8"/>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="222" mass="25495" checksum="656F3774622E4612" modified="2013-03-06" version="1">MKNILTSSSVVAFRYSNGIILSSDTSLNYGSLKMNRGVEKHYVLSNNTVMIVRGEYSCFQELKKICDEEMEYDQSMGTKEWIRFVQRVMYYKRTRVMPLNLSVIVAGYDEHSEKQEKQINSVEHFGQGLIFGVIDNVGNFYTDDVLACGIASHMALPYIRGHGSTSLDREGAIKLMKETMQTLYYRDCMADNHIKIVGVEKDGIWENEEMVLNGNWEDGKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZV2</accession>
    <name>L7JZV2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase III transcription factor (TF)IIIC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZV2"/>
    <dbReference type="STRING" id="72359.L7JZV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0163"/>
    <dbReference type="HOGENOM" id="CLU_824125_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZV2"/>
    <dbReference type="OMA" id="PWRRSWI"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="2">
        <location>
            <begin position="157"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="347" mass="40961" checksum="D4F3E93401C32716" modified="2013-03-06" version="1">MKNFDLIEHLFKLQDIGELYLVKSKDTYECRIEQGLDGKKVFTGSASTKRRFLHIRDGGIHGVSNGFFTFDNPADFAVPCNNEFYLDFFEKMMKLDTETFLSYVNSYNLHSMEYPEYASPVLSGDKTFSDYNFKNVTNSRKNKKRQREKHVLAGVERNELVNKLKKLYGDEEYDEILKEVESLFETHKILRIRRFCRLIVHQLKYPLVKIKKFLPLVAFFQRAGPWRRSWIKLNYDPREHFSSYRHQVIILNRKSTEICLIEHPRLIFELEQNKDVNLKECADENGFLTDKGVDLINLYFDKPLILSKSAGKHVQHDNRLAADQADLDTNHEKQRESSEDSDFEIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZV4</accession>
    <name>L7JZV4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquitin---protein ligase</fullName>
            <ecNumber evidence="11">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.2.19" evidence="11"/>
    <dbReference type="EMBL" id="JH993835">
        <property type="protein sequence ID" value="ELQ76571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZV4"/>
    <dbReference type="STRING" id="72359.L7JZV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0440"/>
    <dbReference type="HOGENOM" id="CLU_998145_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZV4"/>
    <dbReference type="OMA" id="YLNCTEI"/>
    <dbReference type="OrthoDB" id="2196293at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF9">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="227"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="279" mass="33252" checksum="98EDE4B5C07D6013" modified="2013-03-06" version="1">MLHFFIYHLSLLFNDKFSILESSLQKLEHVKMDVVHGEIYDTRKIEITHQDRCASTKNSVDYYITDYTYGMKRKLRFYRVISLDETIEYLYNLSLDVDVLVLLIERNYYLNCTEIMEKMMKRRNKAVLVLAMDTTNSRLMYSALMDSIGGNTSYRLQLRVYRGIERVFIVAFYFLLTVLIVLCFITLQIWLRNQTTKNPLITPYELNRCIVDKYGKLNGSNRPFESCLICMDEFTNESVCRVLRCNHNFHKECVDPWLKTKSSRCPYCRELIKVHEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZZ1</accession>
    <name>L7JZZ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0086"/>
    <dbReference type="HOGENOM" id="CLU_2067133_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZZ1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="119" mass="13105" checksum="7E3744A2AFA6D858" modified="2013-03-06" version="1" fragment="single">VYSVATAIDCYSVAMDFNVGRSLEISLTLFVAGGVVLRRCVCRDVYKLFARACLYGLATHVWRSLYYIGVRRGCSASPILFTCTSTTCCLEWRQPPCGPGWKRAVIRAAQLMLPAGFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZZ8</accession>
    <name>L7JZZ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0649"/>
    <dbReference type="HOGENOM" id="CLU_2433027_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZZ8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="91" mass="10691" checksum="4078D401CCB069CA" modified="2013-03-06" version="1" fragment="single">VDVDRKVREELIDRLVLYVDSKGTNVRDDVLLVALEYSGCLGIVFGGCSSVFYEKLKNKLISLRKWLKSRHFIGEDYCVMYEAMRFMFKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7K020</accession>
    <name>L7K020_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Casein kinase (Serine/threonine/tyrosine protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993853">
        <property type="protein sequence ID" value="ELQ76382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K020"/>
    <dbReference type="STRING" id="72359.L7K020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0638"/>
    <dbReference type="HOGENOM" id="CLU_019279_2_4_1"/>
    <dbReference type="InParanoid" id="L7K020"/>
    <dbReference type="OMA" id="QTPTAWL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="217" mass="25378" checksum="7019E8D189628503" modified="2013-03-06" version="1">MIAITVLESLEDIHGCCRIFRDIKPENILVGNDNPDELFLIDLGMAKYYMNPSSREHIPFINNKKLTGTARYASLNTHMGYEQSRRDDLESLGYTLIYFMRGNLPWMGVRAATGREKHTIIGEKKKNTSLSVLCGDLPARTFLIKYLEYVRNLNFVEKPNYKYLIGLFKSALSANDLSNDKNYDWITQEYKKQKKKKSKNNWWHKFKDFINVCKSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7K030</accession>
    <name>L7K030_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993800">
        <property type="protein sequence ID" value="ELQ76965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0041"/>
    <dbReference type="HOGENOM" id="CLU_2656200_0_0_1"/>
    <dbReference type="InParanoid" id="L7K030"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="9227" checksum="CB3F2F034B8B7E76" modified="2013-03-06" version="1">MKKCFLAMRDNLTRPEQKHFKINEPARYLQSMEEYFFVVCARIENKNNLEQKLRNNCIRKNALLNMVINMNDRVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7K038</accession>
    <name>L7K038_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Armadillo-type fold, Pumilio RNA-binding repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K038"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0385"/>
    <dbReference type="HOGENOM" id="CLU_659202_0_0_1"/>
    <dbReference type="InParanoid" id="L7K038"/>
    <dbReference type="OMA" id="RIFMEYF"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="417" mass="49060" checksum="8BF4BA4B89EA0121" modified="2013-03-06" version="1">MDQTAAYLKNLDISVLTTNKPALSRVHSQIKPYITGLSTSKTTSDKIKEILEICDEKQLLELTREIKVENLVFHNLGSKVLEVFVKGGTYKFLRSYVRTNLKRCLNDDCATFIVRGMIEKGYQVVITPDDIDFEKECVLNTIIVYLRSSNTLKDSKDAIEKRKVTKDSREMSNHSCSLAEEIGRAKRSIIKHVLQTLFTYEKLTEMKYSFFLENFVQIMGKKEIKIIYKKIKNKLQLLAVNKYSNYMIQSFIEKYEDTIQIVNSLDLAPLHENIIIKILLKLQSQKNDKMVEKVIRKYYKDIKSFLFVNDCVNIRCLKVAKRLFIIREHNMNINEAFYESFSKASFKGDIKIVRYYLMGNEETTKKNLFVRKMMSECWGKKGEEMLVWMSRCCDYETRKKILKQLRRRKKINTNRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0B1</accession>
    <name>L7K0B1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0B1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0143"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0B1"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="972" mass="113312" checksum="897B3D221BCA84E5" modified="2013-03-06" version="1">MLANLYSYVEITMKYILIFETAPDKQQDYMIFEDLDDTGIKNFLSTCSRTTLTEVSDYDFGRYDVKPPPYKKTRRTNEYVGYNATYFSKHFHGKDIKDKSYKDIIEEEHKTEFRVINVPFSKTTFEKIYELKIHDDIIFTNEEIYLIFFYLYPHKENMTKLTRVICFHLQRNPTMVQELFDIAQDCNIKYNDRMTCLAMIINPECHYVKDFRRTVKSSIIFALKDKRGESTTINNNTTHYNAFYYEIELDKLNIAFLIESLAMSYDYFALNHNILYEKFRNVLDKSCLVIKIHNIHGNHDYTRPELTTETTILKCKLTLIAESEFLKCSCIQEIILQFNNVQVSCEYDILKSINKLSMVIFELNSFENLKSIPKEIKNHEMILKNVILEPTLTIPDTLKRISFQESQFCESLIFPNYIQSVAILRSDVNQDATIIFDENCENVEIDETYIRIKFQEYVELNYILLTGKKYHNGGKLCYSKGKCPGEGFFIIHYANIFGRLILNINLQKVDFFFVNMSMDSQIVLCAHNKYFDISLSEGFFDLSDFIGISLHFTRKMSIKTDSIEGSTGKLLKIIIKDMELSENIVLSDCFESVELENVTLKNSSILVLNSKCKTLIIKNFDGVIKVHDRAMRFETVDISFAVNTKINIFFLGVIYADNLHLSNACRNIERIKCIFSTIQGVRNLKFTRKFTHEWSRPAEKYINTLRRIPGYQEIAEKYSKILSENSSVRSRLRKELFYKTSTAVVNSVLKTLLNASVIETIQKIEFKSITLDDCNYEILYGMKNLQILSLGHPNFTSALFSHLPFSLRLLDISWSDSNCEVEVVRHGLTDLMNLQRCYSLNVLVIDAGLFFQAGTLNFVPSSVTILKVYFTSSLEKFKSSKNRKLYLNELYIEGEALGLDQNSTEIGKTNAYAAIKALKKCIEFEYLKQFAFVCSNVRKEIDPYTLKFYKRESEKFFTVDKQKHDEMDIFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0F0</accession>
    <name>L7K0F0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0F0"/>
    <dbReference type="STRING" id="72359.L7K0F0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0366"/>
    <dbReference type="HOGENOM" id="CLU_906691_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0F0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="307" mass="35340" checksum="7BDB8B85E9E88F31" modified="2013-03-06" version="1">MSQGTRLVRKDNEHCLITPDFEEIVKSLEGICGCNFDMFEIANMAQVNELLEKIDRFLIKSLSKHELNILTRQLVVVMRQVESSFYVVLENTMKNITGEIIITASNTEKGNPTDLKKVELLLVLGNKVLELFLVITKFNEKWENGLIAKGIYKETMENKCLKVKQNLSRNAALELGNLAVQLFENIRSNFLNAATGLQKNQMINMVSVNRYLISSFCLLCSISPNANHTMCLNIEKEKVFFIINYILNRNSEYVSYFLTSFSQIYDDDVLSDDERRIKVKIVDITGTEKKTSENYFTQKNNNEDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0K0</accession>
    <name>L7K0K0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Golgi SNAP receptor complex member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0K0"/>
    <dbReference type="STRING" id="72359.L7K0K0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0154"/>
    <dbReference type="HOGENOM" id="CLU_1409722_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0K0"/>
    <dbReference type="OMA" id="CKQKRII"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="193" mass="22437" checksum="21AF9F77E14EBAB9" modified="2013-03-06" version="1">MFNSKTLDDIENYIVRIKKDLMVFDINRDDITDMAIEISSLGNMLLDAEKHIGELTDEKDTERLFAYKKTLNELRDQLNELNRLRVSNASFEEISRCSEVDDEQLSESQRFYKRGNEKLDSIISDAVNNLDSLCKQKRIIHKTRNTLQRGKDRIGSGIKTLKSISDRYLNDYYVFMIGLAIIVFFIVVVKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQS5</accession>
    <name>L7JQS5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribulose-phosphate 3-epimerase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pentose-5-phosphate 3-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">RPE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_3287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQS5"/>
    <dbReference type="STRING" id="72359.L7JQS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3287"/>
    <dbReference type="HOGENOM" id="CLU_054856_2_2_1"/>
    <dbReference type="InParanoid" id="L7JQS5"/>
    <dbReference type="OMA" id="IRTINHM"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ73808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="251" mass="28015" checksum="AE069264EB39F15F" modified="2013-03-06" version="1" fragment="single">VFLCHYVLIFIIVLIVSLLSHRLCPHSHHPPNCHSNLSSLSHHYLLIISSSSLKPSPHHSTTPKMKEIAISILNAPILTLQKELDILSQSHPQPRIHLDIIDTSFTNNISFGPSIINQILQLHFQFDLHFMIKSPLALLTKIDCTNVSNIYMHEDVQDYGIAINPDEPVVYKQKVLVMTVYAGEGNQAFISPGDKIAELKRQGCYVCVDGGVNLENVGSVRDADCFVIGSAYFRSKDKNAFLNSVYEIVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQT3</accession>
    <name>L7JQT3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-dependent ATPase MCM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQT3"/>
    <dbReference type="STRING" id="72359.L7JQT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3258"/>
    <dbReference type="HOGENOM" id="CLU_1954069_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQT3"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM AAA-lid" evidence="1">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="129" mass="15502" checksum="647F01ABF0EC7C0A" modified="2013-03-06" version="1" fragment="single">VLNRSEIKHKKQQWNVCALRDYLEMIRNDEKDATIEATDLIDTYFKWRKAQKTEMFTIRNLESILRLSESHAKLLGKNILDEDSVLMAIFLVESSLWGSKRIEFDKKRIFIDEEYFNEKKKEMITIIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQU3</accession>
    <name>L7JQU3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase III, subunit C34</fullName>
            <ecNumber evidence="6">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6"/>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQU3"/>
    <dbReference type="FunCoup" id="L7JQU3">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JQU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3268"/>
    <dbReference type="HOGENOM" id="CLU_033661_0_1_1"/>
    <dbReference type="InParanoid" id="L7JQU3"/>
    <dbReference type="OMA" id="QGCTIRD"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ73828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="235" mass="27504" checksum="3C28A5937420C217" modified="2013-03-06" version="1">MSVIKQVFDFIQAQPDGVTEEDILKRFPDLSKDQLLTELTKWHLENRIKKDKKNKIMYVRNTEDDEKSVLDVLKKSKGQGCTIRDIRLTTKLSQNLITKILRKMQDMKMVKAVKGQKNRQNIFMVFEETPDDEVTGGIWFNNGDVDVEFTNQLIKLIYTFVRNKTRDLISYDHNPTIEDIKSFITESNVLSINISMADLRKIIDVMVYGQILLELRDGDRIMYRALRSHENEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRF0</accession>
    <name>L7JRF0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ74048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3037"/>
    <dbReference type="HOGENOM" id="CLU_084107_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRF0"/>
    <dbReference type="OMA" id="DECSITV"/>
    <dbReference type="OrthoDB" id="2194424at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="289" mass="34061" checksum="8D12B6A16709CFBE" modified="2013-03-06" version="1" fragment="single">VLQQLRYVIFLLTFISIAHVTFDAWYMRVTMKKLKNHSFLFSQPRICTLLDISINMFFCSFKGHIKLFYSIHVLNLCKNKKITNFYPMVKSMDAEEARVQLLEQGFTNELIEEALKNTSSTNLEILLDYIEERLSKMESCDERSVLETKEDRERKKKLEELKKQKELRRQERLHLKKLRDQIKADRIELEQEKKKEREQENVEKSVEVKPIVGPDECIITVLNLENGESFDVIMKKNECVSTLLREIEGKVKLADPEIFCGDDLIEEDKKSLDEHGFHPFVTLIVKNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">LTR Retrotransposon</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">THOM_3026</name>
    </gene>
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3026"/>
    <dbReference type="HOGENOM" id="CLU_206113_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRL6"/>
    <dbReference type="OrthoDB" id="8057740at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7587" checksum="624AADBF594DBB9F" modified="2013-03-06" version="1">MFLNDLTEKYPYKIPDMKRIIETTTRSNNLTVLDLKEDYYQIEIDEVYKHKTAFEFENNAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRL8</accession>
    <name>L7JRL8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994073">
        <property type="protein sequence ID" value="ELQ74118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2962"/>
    <dbReference type="HOGENOM" id="CLU_940731_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRL8"/>
    <dbReference type="OMA" id="HYKCALL"/>
    <dbReference type="OrthoDB" id="10360599at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="348" mass="39555" checksum="FF7566F120CE1E5A" modified="2013-03-06" version="1">MVLTTVGSWIISIQHYVPPPLYSLRIRTPMKDTINPTATPQEIADLNRKIAQALKKSFFKSPDYTTASIHTSALALLTTPLNHYKCALLQLILKEHADAMFSMLKAAEFSTYFYERAGALSFVNGCYSIGGNAFVKGYEGIDNDEMCMAIRRWIGDREDAIVEMMKMGKDCDVVDDYERYCRDSYEDEYGTRERTEDSNSVKNKTEDNTKNSSAKNNSTKNMNVNDTRNIIRSSTYIPATDTSIPALKLNYLYNAHVLYKKAQMPKTADLIKSKILRECIIQRKYEHAAYYACANTDVMRMLMFLNGGDDDELKMMDEQALKMMGVDECGGMLVEEILGRRGSEYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRR6</accession>
    <name>L7JRR6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Bromodomain transcription factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2927"/>
    <dbReference type="HOGENOM" id="CLU_1225578_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRR6"/>
    <dbReference type="OMA" id="KNNFHTQ"/>
    <dbReference type="OrthoDB" id="2189721at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031498">
        <property type="entry name" value="Bromo_TP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17027">
        <property type="entry name" value="Bromo_TP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="223" mass="26501" checksum="A3B97554EFB21F6A" modified="2013-03-06" version="1">MKNNFHTQILKLCIAEILIQSGFERTTSMALTTLTHLLTFYIAYLTKRPFNRPFLTTKHLFSNLCHRERTELLSYLQAQRKTCDRNQAALNILEQLRIMPDEKDETVEECVEENKEFKTMRDSGGVSDVLHNFIVECKRRIEEEKSKEQHSDEETKDTLFDTVEQHRSMKNIPPFFVGKPCVNRLRRDAKEYAEMMEWRRGREESGMVTDELLCFSRRRVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRT9</accession>
    <name>L7JRT9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3072</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994087">
        <property type="protein sequence ID" value="ELQ74015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3072"/>
    <dbReference type="HOGENOM" id="CLU_3207934_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRT9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="45" mass="5071" checksum="E67A19B841942ABC" modified="2013-03-06" version="1">MSDYAPCVCTRFDAWVGKTIVIFSHSIDTCIANEVTAHNKIYVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRW6</accession>
    <name>L7JRW6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
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                <person name="Goldberg A.V."/>
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    </evidence>
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    </evidence>
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    <sequence length="44" mass="5288" checksum="7DE90339006D3B68" modified="2013-03-06" version="1">MPNTLKYTLQSFMKDFGDMKKIYLKKAVNQHKRFLARARTLVKK</sequence>
</entry>
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    </evidence>
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    </evidence>
    <sequence length="184" mass="21099" checksum="F9C3844695E71694" modified="2013-03-06" version="1">MSYIISTLLGTIPYLPFKPINHPIEVFLEDFPMHLIKKGQLSHILPHSTVTHLSTKHPTLIQTKQGHIKMTAHQLNAIALDNHFKTARIAVPNDIHEFVALMGQGRTDVCVRFVNELERRIVVDGDDRNYNTLVRVNEDYVDWLRESGDMLYMSVVVEHNMGVVERLVGMVDELRDGEIDVTYK</sequence>
</entry>
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    <accession>L7JSC5</accession>
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        <submittedName>
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    </protein>
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        <name evidence="5" type="ORF">THOM_3152</name>
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    <organism evidence="5 6">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Goldberg A.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <name>thiamine diphosphate</name>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
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    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="4">
        <location>
            <begin position="278"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ73956.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="587" mass="66150" checksum="7A4CA3C4E768DF6B" modified="2013-03-06" version="1" fragment="single">XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPLLIPLCQFITLMINLFAAQGQMQKTYKHKLNLENIDVYLLNKQDMDKEYEYNVDELKEMYVTMLSIRRLEECSQQLFDANKIRGFCHLVSGQESIYTAYKYAVAKDDTATSSYRCHGLSYVTGDSAKVILAEMLGREEGMCGGKGGSMHLYNKTFYGGHGIVGAQVPISLGLAFRHKYVNLEKGDRLDKMVAKNVSFAFYGDGAANQGQVFESYNMAMLWKLPIIFVCENNAYGMWTKVETVSSNINFYKRGDNIPGVRVRHENVLDLIAVFKFSREYALKNSPLIVEILTYRLCTHSARDQVDFRSEQELKDKKSADSIEHFRSFLARFVPENEIVNIEKSVCDTIDGESSLAQAAKEPQAAELYTNIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSC9</accession>
    <name>L7JSC9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2686"/>
    <dbReference type="HOGENOM" id="CLU_2110652_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSC9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="115" mass="13401" checksum="83AEA7AC36FE6787" modified="2013-03-06" version="1">MSFTPRNSECDTLSDTQKEFEFDREDNQDIDYTGTSNARYRASNNYGEVRTSNLISRCTGIMNMCDETELLNMIILIFCFVLILLCLKKIATMTKRKNRRGPYALDKEQKFKSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSP9</accession>
    <name>L7JSP9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nuclear pore complex, Nup155 component (D Nup154, sc Nup157/Nup170)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSP9"/>
    <dbReference type="STRING" id="72359.L7JSP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2598"/>
    <dbReference type="HOGENOM" id="CLU_014149_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSP9"/>
    <dbReference type="OMA" id="CNGERDY"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="881" mass="102622" checksum="E8D94AA841AA5F2B" modified="2013-03-06" version="1">MIENTEMDLFVKAEEKFKTPSVSVRQILNSCSDYSTEKKLKKARELQIPYDLRNYIVENDKAYESGKTNGIRYGVLEEINTLYVIHDNTLYLYSFLSSYKNVLPFSENVLFVRCLKPKASIFQKKILTIILVVTQTKLFFFCVKEGEDGFFEVKIEHTFTEALKDIKVNDDSRIFAITKYDVMEVKYDMYGCTSHNPDVNFFEYFMPILFLRRKISPIVDFDVKNNFLVTLTRNEIVVYALSKFKKINVILTCRTYQKIGIVEEDGTNVVVNNKLMSTNVLICAVGCNGERDYYDSTRLLFSRECPLKTKDTDRFEVQGTNFVVHSSDKNVLVVLNDDQLYNFDKKRAAENYEITGNGRLFCGKRMFLVSDTVIVYEHLKGPEYLLSTKNTYRAARNYGQIVSLFYLLIKADNRDTNSFDCSFSQIDRNFVYLAVVHIIQHFYRLPIRKIYLIDLDVAIRKLRNINEYDAFVKKVIGCLNFVKIAVDYQCTYIMDMSVRDLLLNKYAEKRKKSLESINLLLLKNKCADFLSLNDLFYNSALNLIKRGSREALARAVDDLLNCDVEHSIFQRILDAKYYLGAVKLLKKMKLGYEERVQLLCKSLLCQNALLEALDDPREDFVYAVFDAFLRNKSRFNDCLCCDEKCDDMNIISLSSPFLESFLREKFYESDNKEEFDLYWKFLIYKKRQSEGVKCINTLIDIKQLTLEHKIEYLTVVSAFDQSNKTKLQIAKLQYEIANRMKTAMDTLLDAQTLFNEYAYPNGFYDIALKLLDLCDCEKEVIFDVMLKYLKGPASEIEGKLAKLHLKGSCHNISVILTIFLSKKLSDELNVCNMLNNLNYNKDKIVETIRKELKYNVSPDVKKYLAKCIRSTYGMSENEINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSX1</accession>
    <name>L7JSX1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994070">
        <property type="protein sequence ID" value="ELQ74136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2942"/>
    <dbReference type="HOGENOM" id="CLU_073160_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSX1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="329" mass="38125" checksum="E3BEA10B8170CD07" modified="2013-03-06" version="1">MRSFYERIADRRLKMKQEKQEKNKDNGHNETTPKPPDMSKVRVESTKFGGADEITINNIKNKNKKNVNESDTYDGTENKENMTSHSDCGARIASLEQQLMAIMNELKSLKNVLVNGNYQTSKSMSEVSDKVNEKANVFKNFEAFNKQTQEIETKIRETNNKRLRATWPKSPEENEKNARKKRPEEKKLTPEEQLRILNGGPVQEVSKVQLIHFCGLGRNRPSNIRRLLRDGGIRSGSIVHVGFDQENRLEILAYVDTIEQIRKFLLSFDGVCQENSRTVVGGLDDENLERLRTRMESATEQKDTTPPVKRFNNIFKRFLKEKKRKTLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT25</accession>
    <name>L7JT25_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3185"/>
    <dbReference type="HOGENOM" id="CLU_1455369_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT25"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="186" mass="21301" checksum="891465CD5E1A98C6" modified="2013-03-06" version="1">MNVNNIQLPCTHSTKKTIRDNRRGDIPSYDYEYIDCDTNEHSYPDHEENNRTDEIINNKEDHKSYEVDPTTPNYFSNENITDIIVTTTAKQPEDESSVDWSLFISISLAILLILLLLLLCCLYRIKIRRSGKYKVKRAEEKSASKKKSEDEGSTSPKNERSLEEDGNADSSPIQRVPKNKSLTTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT80</accession>
    <name>L7JT80_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
            <ecNumber evidence="8">2.3.1.23</ecNumber>
            <ecNumber evidence="8">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.23" evidence="8"/>
    <dbReference type="EC" id="2.3.1.51" evidence="8"/>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT80"/>
    <dbReference type="FunCoup" id="L7JT80">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3107"/>
    <dbReference type="HOGENOM" id="CLU_052673_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT80"/>
    <dbReference type="OMA" id="NITQFGQ"/>
    <dbReference type="OrthoDB" id="2192045at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ73967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="394" mass="46051" checksum="2CBAED54F587128E" modified="2013-03-06" version="1">MSQVRFVSSLLLTLLFSITVRHQKYNYLFGIALLFVAYGFMAVCLYFYVFFFNLLVIYFLRNYKHKKHVVLVVSITSLLLCSYYYKVMTCTKAHNICGPIMVLVIRLYYLAKELDCDNAFYTDIFNYVFCIPGVIAGPACSLTDFEKNKSKAINKKMALKKLAESLLYLALHLLITRNISYAILLDRDLIFPYKILYLVLIGFGFKCRYYFIWNFTDACYIFNGFQNMTNIKAIDSELSSDMKELAQSWNLYTNRWLKDAVFDQLKSRSVFLAATCTFIVSALWHGPKMGYFFMFLGFLFGTTVIKSNYKIFGSFFSVTTLRVLGVIQTNLIVNYLIIPFSLLDTSIVYEIWGNVYYFVHFWYVISLIGFLWTKGKGSDEMRKLQMKQQRRKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTB4</accession>
    <name>L7JTB4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein involved in the nuclear export of pre-ribosomes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTB4"/>
    <dbReference type="STRING" id="72359.L7JTB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2482"/>
    <dbReference type="HOGENOM" id="CLU_611398_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTB4"/>
    <dbReference type="OMA" id="HLMPREG"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="440" mass="51664" checksum="886B2D3729ECE8D5" modified="2013-03-06" version="1">MAEQLVHENSYALSDENEDQVIKKIALCSKQVIIDPKDNLLNVMYIFDHCHTFPEVSLLSLLRIFLDIVPLYKIKTLSNEVKDKTQLSKLNKWEQDLLMIYSKFVFLVTKDTNDVNYKCAAELLKELSHFNYVEKLVSFVLRGTIVENAVCCECIARIFKSDDLELKYKMLVPMCELNFGRNVISNFLDIDIFEFQAVKDKFFTGFIYENEKKRRKDKKHADGLLNKDDKKKMSKEERKQEKIRKQVESRRLEEEGIVDKEKQKKLELKICNCILRIYLLVLERRRSDLYAEVFVGLRKFKVIVKDNLVEGTKLLIMGCLADSSAETKFLGILAVLALYEDRIIDLNKLRDYLYDLLEPRTLRLKSSESKLAAKALKHFFLTNKQSVTIVKMFIKRLMVLCSLDYLPALSVVIGEMMEYYDIDMVIDDFQEFSVYLKMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTC2</accession>
    <name>L7JTC2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin thiolesterase, putative peptidase C19</fullName>
            <ecNumber evidence="2">3.1.2.15</ecNumber>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.2.15" evidence="2"/>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTC2"/>
    <dbReference type="STRING" id="72359.L7JTC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2493"/>
    <dbReference type="HOGENOM" id="CLU_438176_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTC2"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="337"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="624" mass="71884" checksum="75CAE88F8F4AE070" modified="2013-03-06" version="1">MIILLYIAILDVMATENFEDSDDGYIIVSDEDVITGYPGRLGANSSEKLMCEQRENHQTYSYDQYMSESGYYNTFLDENLINYLGTCVSSEFHEQSQRNLPERGILRLQDSDQELLSDMFETKRMYEQEYVPMPATSLDSFIESVFSDDYSQRQSSNFVSEQNNISDMFETKRMYEQEYVPMPTTLLDPFIESVFSDDYSQRQSSNFVLEQNNNENADFYRIQAIDEVPPVQQPYYFNGLENDAIFSYVDEFNSTSFTCINDASASMRSDGDHPKIKQEDFMTSADTSDQGWTEKLLATTSRTKYTADTISFLGKIQTFLDRNTILVPSNDGGSGPTGLPNKQSNCFFNASIQMLYASQSFVDFIKSDSLKSLCSMETLRLIHDMLKKNEKNVWDVFLKLCASSKKLIPYGNILEVKQHDAVDFLVDLFEEIWNMAGDKSIHLEYPFAFISNEISICATCQKPTSIKQFENCYVLDLKAEPSINSQLVMFNCLEEDIRSGNIKRCKHVYSCEHTNTILKTCANVPKLIIIRIERNIFDSVLQKTKKNVAPIDTEEHITINTRDYRLKSFIMHFGEDNAGHFTAVVRKGIKWYHVNDDVIGLINDIHRFLKGNPYTYLLLYQRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTJ0</accession>
    <name>L7JTJ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Karyopherin (Importin) alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994033">
        <property type="protein sequence ID" value="ELQ74640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2424"/>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="InParanoid" id="L7JTJ0"/>
    <dbReference type="OMA" id="MVRNATW"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="571" mass="64691" checksum="0A7C1F14CEB06F7A" modified="2013-03-06" version="1">MAKSFMFQNTSTENRKKQREEKQIELREKKREELLNKKRTMTVCDASTQITDFKLKKELLLSKDPQDVYKGINQFRTSLSVENSPPIQSVIDSGLVPRFVELLSAECSLYKNADKRVVRSIRMEAAWALTNIASGTSEQTQAILDYGAIPLFADMLKENDEDLVDQAAWAFGNIAGDSEKMRDAAINCDVLKIVINLATQLLKTNASLRVLKNCTWVLSNLNRGRNPPPKLENMKASLDVLQHLIDYKDDEVLNDTLWALSYICDNSPEAVDMVFATDVLSKTLDILRNHYEYNSVKVMLPAIRIVGNIVTGKDEHVDVLLKRGVLGILKDIFVHFQGDVALKKLRKEICWIFSNIACGTKEHISSLVNENIMELLYSTANLQNYIKMEACWAITNMMSHCEECYEHFELVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYFYCCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTJ2</accession>
    <name>L7JTJ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3029"/>
    <dbReference type="HOGENOM" id="CLU_3144007_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTJ2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="6750" checksum="E181A1A5E73AA305" modified="2013-03-06" version="1">MVENSVTETVTSETVNSGTIGPEKKMKLLELKMKTEGIGDEKEKVMFVLKIWMTKSWNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTL6</accession>
    <name>L7JTL6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2310"/>
    <dbReference type="HOGENOM" id="CLU_2747202_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTL6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8068" checksum="E11EFB78F7E3CE28" modified="2013-03-06" version="1" fragment="single">VIRMVQSTSTYYHNTYHILHVIFMPGKKRAVIRPFNHNNEQSLIITTAGMLDRSDPPVILPSSLSLILFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTT6</accession>
    <name>L7JTT6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major Facilitator Superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2234"/>
    <dbReference type="HOGENOM" id="CLU_051363_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTT6"/>
    <dbReference type="OMA" id="CFRIYID"/>
    <dbReference type="OrthoDB" id="2191737at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="417" mass="46775" checksum="F95F48762DC149F9" modified="2013-03-06" version="1">MRKILLFHALRTFSPITPFITPFFVEKKQIKNTAFHNKVIPFFFISGFLASLVGPLFVEHFGEKTILIWDTVLDLVFLGCFFVIPNGRVAPLIVITCMHGASSSLGLLTKGMLYAEGGSREKMYSTFNIIKRVSSILSSWIGQDLFYACSEYSPSLVVSIVSTACCLLTAFFLTGTERKAKESFLNTAHMLTRDTFTRNYVFFGVLNIIASTIYISFAFYSASIFIERRKNTNLASNAVGRVLYYVLLPFRALSFLIIKALAPVMQVRYAPKYDQEKLIFGYIDGIAKIVSVLFSTLLTRTNYATRTLAYLCLFLVLCTIVCTFLMGYTSTLISSYLCFIVGATLSNTLLMLTHSGFNKAPHLATLLGVNLTVSSGIHIGISYFSKWKKMGAYHKMYLYLGTSVVLYAVALYVRWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTU2</accession>
    <name>L7JTU2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2356"/>
    <dbReference type="HOGENOM" id="CLU_1295277_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTU2"/>
    <dbReference type="OMA" id="YMVLRNN"/>
    <dbReference type="OrthoDB" id="10310083at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031502">
        <property type="entry name" value="Zf_ribonucleo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17026">
        <property type="entry name" value="zf-RRPl_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="213" mass="25631" checksum="CADF700393043278" modified="2013-03-06" version="1">MSLTCTFCTRSNLSTYNDLWYCPTCTVYLKQKNGRLFYHYIPSKIDGTIRSLNDILCTKCKTMNTTVKCTNFDCFYRKVQYCDTCKARGYMVLRNNFYKNLPRCHRIRQRYTLLSYVIVALLMLMMHQYTFTKNFVIFVDELYTRRFNFLKFVMKLLICWALRDRCNIRLLVLMGLAWYNMVCEYESVFIVKISNGLIDDSFIDRFHHLHIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU15</accession>
    <name>L7JU15_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2454"/>
    <dbReference type="HOGENOM" id="CLU_450696_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU15"/>
    <dbReference type="OrthoDB" id="10600786at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="606" mass="68710" checksum="B59DF75C79399465" modified="2013-03-06" version="1">MRVKGEFNTPKNFFIFIKNRNFILMEKIEVIEDGVVVEKRNNDKTMVEKNEKSTDCSPSSCEFSGNISESEVINQRDGDEKNVTVDKSETTDSTLEGDNEDSRNKLGTCMNECKDSSCAYGKDDKKDVNKMTDEMIANKSAGNTEDNVKRDENRSNNNETVNEQAKEGVVRNITEVKEHKIEGVEAPNKEAAKKTHQKTSASPDLVIGGIENDNLGDCEGSKTKNETKSVMKDKSYKEENVENRLSDTALSTMSSLKHEYFSRIKDLNFFLTELNFLVKSLKSETIRQNVVEYVAKADKETTSRLYRLYIAHIKLTYKLRAVYNTYNNSECFFSHISVIFRLYSRMSEEIVKFVADIFGKEQSELKDMMKCLEDAFDELKDMDIMDYVEIMVDNGSVVSVEDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKIIFVLERKRSLAPIKLNITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU60</accession>
    <name>L7JU60_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU60"/>
    <dbReference type="FunCoup" id="L7JU60">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2061"/>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU60"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905334">
        <property type="term" value="F:Swi5-Sfr1 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007533">
        <property type="term" value="P:mating type switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000708">
        <property type="term" value="P:meiotic strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036298">
        <property type="term" value="P:recombinational interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="101"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="9">
        <location>
            <begin position="280"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="343" mass="37480" checksum="2269682DDABD16AA" modified="2013-03-06" version="1">MSKKELEMDVDNEEFREEIQLTTGPISVDELKNCGIAAGDIARLCEAGYHTVEALAFTPKKQLMTVKGFSEAKAEKILKEAAKLIPMGFSTATSYFQKRNNIVFITTGSQELDKLLKGGIETGSITEIFGEFRTGKTQLCHTLAVTCQLDRENGGGSGKALYIDTEGTFRPERCIAVAQRFGLDSDQVLENISYARAYNSDHQSQLLVQAAAMLSESNYSLIIVDSAMALYRTDFSGRGELGARQIHLARFLRMLLRLADEFSVAVVITNQVVASVDGAAAMFNADPKKPAGGHIIAHASTTRLYLRKGRGETRICKIYDSPCLPESEAVFAITANGVDDPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU76</accession>
    <name>L7JU76_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994001">
        <property type="protein sequence ID" value="ELQ74974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2085"/>
    <dbReference type="HOGENOM" id="CLU_3263272_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU76"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4961" checksum="24E9865EB44E0B64" modified="2013-03-06" version="1" fragment="single">VYSYRIRTFYPRSLKVEKACQLSSLRLYADLLNAQRPEILNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUD6</accession>
    <name>L7JUD6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2725"/>
    <dbReference type="HOGENOM" id="CLU_2723996_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUD6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978817" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7614" checksum="801B8EA0A51D9691" modified="2013-03-06" version="1">MHILSLLFSVIAAREGVAKKSQLFNPFSSWNPFGLRTPSPAAEIEKAAIRRTAAANAAAAANGFGSPFTGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUH0</accession>
    <name>L7JUH0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apoptosis-related protein/predicted DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUH0"/>
    <dbReference type="FunCoup" id="L7JUH0">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1998"/>
    <dbReference type="HOGENOM" id="CLU_2514349_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUH0"/>
    <dbReference type="OMA" id="CEESAPR"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="85" mass="10051" checksum="58598AA1B974E4C1" modified="2013-03-06" version="1">MSQQPNTDQLLASILEPASLTRFNRIKLYNKDRAKKIENELIRLYKSGRVQRQINEDEFEEFVSNLCKENAPRIVVMRKRNEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUI9</accession>
    <name>L7JUI9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUI9"/>
    <dbReference type="STRING" id="72359.L7JUI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2400"/>
    <dbReference type="HOGENOM" id="CLU_759070_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUI9"/>
    <dbReference type="OMA" id="RKSEMKH"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="365" mass="42478" checksum="5F7F21B9D65BFE97" modified="2013-03-06" version="1">MVCRKKIFAKNGKKGKYNGDKGRVREYKKENKTNYVGLERKNGKEARERDNNSSKYHKKDRKNVAGNITINRRKSEMKHTGNIGDNKKILDRKYEKKAPANTSDRRGGSAKRKSEDTKPKKKLNKENDHELEKNSQLHKIYCMEENGDEINKFVENATKEMVKEEVSYLGYLIKQKEYDRSLCVFMIENISKCIGSNNLKSFLNIVFKLLEVVSIKKSVFHLKIIQSVLRIPFYIPLARKLIELFKLGIAIKDTKTIGKKIDYSKIKLTTEYLRSEELKGFILEESLALLFAHLNSISDSLGFPEISYHVLKELKEINEDNIDLKDLIERIERQVDLITNKRKGIKFVSEKDIREFELSTSKMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUK4</accession>
    <name>L7JUK4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_2627</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUK4"/>
    <dbReference type="FunCoup" id="L7JUK4">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2627"/>
    <dbReference type="HOGENOM" id="CLU_037229_4_0_1"/>
    <dbReference type="InParanoid" id="L7JUK4"/>
    <dbReference type="OMA" id="MEIEIFT"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="12">
        <location>
            <begin position="127"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ74447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="292" mass="34296" checksum="946B2AB68491195F" modified="2013-03-06" version="1">MHKLIKVIREETVKLARNLKNDKSVKELKFYEIIHGMLVDNVKKTKREIFYASPNIFKRQETVNKMIDKFAHVHKVRLIDFNVSASLKGLFYGEVTFIESNKAYTLYQNLIPDMNEVTDITCRFSSVLVVEKDCMMTFIKEVFLRNNRPIDFLLVTGKGYPDYNTLAFLRRLEHMKCQIYGLFDLDPFGLSIFKNYKSKINSMVRIGITSKDVFEYKIMKNELITLTQRDYKLLTSLKNNVIDSEFSEDISFLEGLGQKMEIEIFTSYQTIFIVQYLEKKLMINSLSNIKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUM6</accession>
    <name>L7JUM6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993987">
        <property type="protein sequence ID" value="ELQ75129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1930"/>
    <dbReference type="HOGENOM" id="CLU_980671_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUM6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="284" mass="32898" checksum="7E51C483CD7C9811" modified="2013-03-06" version="1">MESKNFSAIQIKTRWFGLKIYSDKPICNRSLLSPDIFTTASLRCIIFNLKSSNDVAKFTFQNEVITINEYDQCELYDLFDMIISEIKNMIDFQEIRMFMDQMDVLQDGEKSKYYNECYCLGCGHPSIYTTDQNIHKSTNDRLVSTFLEIRHIMDKLDMKISDYFNKKNKFTKRKTKLMKTCSAISLFFSIIQNTLQTNFDVDEMVGCLSITEWSASDVLWIDSSHGPLIPNPTNMFLDCVFRLAYAVLGEECISIHVERKNVKPAFAMVTFLLIGFCEELLKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUQ6</accession>
    <name>L7JUQ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
            <ecNumber evidence="2">6.4.1.2</ecNumber>
            <ecNumber evidence="2">6.4.1.3</ecNumber>
            <ecNumber evidence="2">6.4.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EC" id="6.4.1.2" evidence="2"/>
    <dbReference type="EC" id="6.4.1.3" evidence="2"/>
    <dbReference type="EC" id="6.4.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JH993984">
        <property type="protein sequence ID" value="ELQ75188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUQ6"/>
    <dbReference type="STRING" id="72359.L7JUQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1872"/>
    <dbReference type="HOGENOM" id="CLU_1431289_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUQ6"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="190" mass="21445" checksum="A61B2A9E18A8CDAC" modified="2013-03-06" version="1" fragment="single">DMPVGIIYAYENGTCVLDAPSSEKFSTFIDQINAENLNLIIMANFKGFSGGDTDMKNGILKQGSKIIESLKTFKNKIFVYVGCGWQVRGGTFVILDKFINERIRVFVSMHGRIGIMQPSGLSEVKFKDKCRIKVLERNGLVVNDKNLNELAVKFCELHDHPERMIRKGRVDGMMEIDGLESAIYEYFCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUV5</accession>
    <name>L7JUV5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1911"/>
    <dbReference type="HOGENOM" id="CLU_672968_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUV5"/>
    <dbReference type="OMA" id="FESFMYS"/>
    <dbReference type="OrthoDB" id="10350722at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="347" mass="40423" checksum="18055F478CFFBC3C" modified="2013-03-06" version="1">MADTAVQTRKKFSIGKFILSCLLVLLIAMIAHFVVKYLYSFVFLNEDTDAKIFYSWRIKYADKHMIGPFEHVEDKTWDTKDKKLAKFLEFAQGSENMLDDKGPEHFPRGSVNYYTHTFDWNDTVFLPVRKYLVNMTKEAKEPGKEAKVIFLDLPSLQLSTLKNDEVDGVESMHEAMKHLVDLLNCLINISKEDKLLDKTKAENNPIIEHTFALWNEMGYKYTLRDGKDKKTYDLKRSHVLKFYKHLARASTTVFESFMYSRMFFMFYFYTTSAPVFANEDDPAKRFEKATKLFTQIMARAYKDPEDAKKLSKVAAWIKKSYSPKMLNIPAFDTDEAANVLDVAHIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUW8</accession>
    <name>L7JUW8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2475"/>
    <dbReference type="HOGENOM" id="CLU_3401325_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUW8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="31" mass="3487" checksum="1B3D3C95307C2EB8" modified="2013-03-06" version="1" fragment="single">VLSVTLRPLVHGKKKIRLGNERLICDVENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV08</accession>
    <name>L7JV08_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ngg1-interacting factor 3 protein NIF3L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV08"/>
    <dbReference type="STRING" id="72359.L7JV08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2183"/>
    <dbReference type="HOGENOM" id="CLU_037423_0_1_1"/>
    <dbReference type="InParanoid" id="L7JV08"/>
    <dbReference type="OMA" id="DINWSAR"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="256" mass="29354" checksum="D9ECACB35AE966EA" modified="2013-03-06" version="1" fragment="single">VIIKDFFIKLPPLPYEHKMIHILPFFQRLSPLSNAASWDNVGILIPSNIENNDKKYLLTIDFTPQVLRECIEKNIKKVISYHPVLFDAQRNVSLFTAAIIENRISVFSPHTALDNVMNRTLLSRLGCFDIETADYMAIGNNGKRMRDIIDLLKMTCNVKEIRLALSDIHRMDSIPPYIYASVGSGRFSGGENSIIITGEMSHHNIMKLKKFNTIMLVEHCRSERWFLNHLKVMMEDSIPDVEVIVSEYDVSPVSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV59</accession>
    <name>L7JV59_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV59"/>
    <dbReference type="STRING" id="72359.L7JV59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1665"/>
    <dbReference type="HOGENOM" id="CLU_759107_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV59"/>
    <dbReference type="OMA" id="EYLRHFH"/>
    <dbReference type="OrthoDB" id="2194852at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="402" mass="46856" checksum="748364C355A7EE46" modified="2013-03-06" version="1">MYSRHVIKMFCEVFMRIGTQPIFYIFSIPFSLSVKSSMLRQIYEIFTQKNNILLSSAQMKMLNERKYTIEKYKKIADEYLRHFHNGVATNENLNFVIERIEKSLTCDIFRLKGFEKEFSNDLERYYFLQSMTKGDDMIIFGMYYRNKFDENVVEDDESVVKVRFNIDEDLFIFDGMFFGAAGSNENGEFEIKRIYLPEITVGSIERWDLMQKNVTIAFFSNMKLENETLDRIKAVECDILVLTGKFNVKNISSAVTRFANTCKNDIIVMLDRHEPVKTILPVNFDIKDKPSNLHPTTNPSRIQLHNMDIMVVKDEICAKKVQGTFFKENYYESFTRTFLSQYTYNFDIGFKEMPRLIFVGQNTRAFVVECDGVILASCGGDDNAYIEYCTASGTAAIKYLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVE7</accession>
    <name>L7JVE7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994029">
        <property type="protein sequence ID" value="ELQ74702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2366"/>
    <dbReference type="HOGENOM" id="CLU_115981_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVE7"/>
    <dbReference type="OMA" id="CEHKIVE"/>
    <dbReference type="OrthoDB" id="2196255at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="160" mass="18030" checksum="F98FCE248A8FAD26" modified="2013-03-06" version="1">MTCNLMTNAMAVKEKLDIFSEEFFVGLIAIACKSNDIIMPSRIRKGHQPEKIAMIESMIPTMFGFKMHIPCPFTRMLGLIICLCEHKIVELHVSSVFEKGAGNIKKILLDDNYLEYNVTEVAAAALPVDCKYLSQLMLGDLSCENIEKIRKDNNVILDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVK3</accession>
    <name>L7JVK3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1716"/>
    <dbReference type="HOGENOM" id="CLU_004199_2_0_1"/>
    <dbReference type="InParanoid" id="L7JVK3"/>
    <dbReference type="OMA" id="KLELWCY"/>
    <dbReference type="OrthoDB" id="10421701at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1550" mass="177390" checksum="01BF6829C5D7CC6C" modified="2013-03-06" version="1">MLVTIYILLLKVSSTVIYILRFRNEKNESDDYLTVNSLKDAMLGKMLENAPINEWIGHFLIQPYDHVKDELHVLGKDVCDTIEDRQKDEFTTILEKDEHPTENKKKNTNQRIKWQEETAAVPETQMKIPVENVQYMEVKIPVSQLLYIKIINLSHGKNEQLSDEEIHSVLHLLMSMDNVSEIKYALYMQFLGDHALIGRLRQLHAERANESMDIDVVKQGNIDCLTSDIEHVIRNVYSTMKRNYLLLIKDQYGNTALATRKAKGDRRLKMYIPLEDISAGIPGSFLRMDYNFLCHNKEALYSWIDTLGEEIPKMTIELDFCNFFRLRGCSYECTRVSTNVPILGTFAEFYRVITCNFVIHRKITKIILRLSNVCYDFDFCFLDGVKLELWCYECIFDEKSVLPEFLDLLSVKDSLLKASLSLPPCLNVLYMSNCRHQDDTVVLHVGTTCRHVSIEDHSGLVNFGDITRLCTFMLPLKSRFSVSIVKNLKGQLQNLKVKNVQVASNWTICDTIKRIYLENVTVLDNNSCGIHSKSRSVVVRHCSGLFDFDGFRGFEHVHLFGSKGTLEYVGSASGDVYRFTISNLWINKSRVFNSGWKKILFSDIKLSENAVITFEQNGEIQEIVCDRCYGRFIFSKIVSGVGSIFFTRENGYFEIKRRAPGNEIQLKITNVDINENIKLGDGIAEIVLENVNIEDGYAFETTSPVKKIVVDSCSGEFIIHGIATKTGNGIILRHSSSSIHLLRKDSDNYILYMANITFSDTIEIKFAVDTAVFVNVKVAASQGVVFEKGCERLTLNNCDRLVQKEEGVVFKKLSLCRLASSVAHYYFSAETEELQASEITLYEDVCIWRNVKAISLYRIFILNNKCFEIRGEPDLLSLQQCSKYFNLPCLTEKRDENVLFLSEEQSEIHLFRSRVLSGSIAVGMKGCEIHKDIVIRNDVKHLSLSNITGGSDVKLVISNSCERLIIESCEISVMLAKYSPLISMVMKRQFFIQDISKFVNLQALYIANVSLQQDLILNNHIKVFKMEKSRIEKGYALRLNKGVKNVVIVSFSGVVDTSSIMNMGDVWLNGTETFTFKRENNADDIYLGIRNMIVAKNLKIDPRVKRLELINTTIDENAQLKINSACESVRIVDCDGRIDFSEAISLTFIGIEGDMIGWVNSLTPIVKNRRRIVPGRLFPSHTEKIYVNCKSVKLVSQVIDQDVCLTFDEECESVSLINCAGTFDVSEVLKLKRLVYQPQGALSDIRVEFPDLSNVEELVLVYNGDDRYFPLLLLACRNVKRLTLYSYRAPNAGIRQDDMITDKWTAHAKELKYINNSDIERIVRESSHEDDHFFEKIFNRIMNILIRPIFTSTTENILESLSLYGFKPSVRSMKEMRNFVALETLILDYEYVDKTVLEHLPNNITTLSMLKGQKPLFTCPKLCCSAKRDKAIAFREHKFLKTFVVDADFFTNTKNFFNLPKTLECLKITYTNAFSKANVPVLKKLKLKRLVIIDSDELNNELFLTENYNTNVVRFKTFTCFLSNFIDIFSLDELSAEIGNTVVSLSPRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVM3</accession>
    <name>L7JVM3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993949">
        <property type="protein sequence ID" value="ELQ75533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1511"/>
    <dbReference type="HOGENOM" id="CLU_1147872_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVM3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978845" evidence="1">
        <location>
            <begin position="22"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="290" mass="34136" checksum="BF26DD72F757D21B" modified="2013-03-06" version="1">MRTFVNIILLCFAMLPAYGSATDKCVTKGLIKRENRRNILTIRPSFDGRKDDLYTYINNIYSCLDHLEISIYNTIKLSNEVLNKDRKYRTEPASMASSGLLNDELCMTFHKFKEDHENLWQQSWSESITKIDKCEMIFDLYEIRCIIRRVFVLCNMMVKALMAHSDSEESAPTLRKLLMEQLSELSSNIYELTHDQSFIDKDCIVMVDLQLYNNWEKLCYRWSLMWEKEGENNISRQLSQMYTYCQTMIESNITVSSQTKESMCGMIETKTFGGLWSDDFFGVYAWVQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVS9</accession>
    <name>L7JVS9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1653"/>
    <dbReference type="HOGENOM" id="CLU_2711827_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVS9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="8655" checksum="65B7AA3231931E66" modified="2013-03-06" version="1" fragment="single">VIALKNKVEEQDKKIKTLMEMFQQMFNMQADKGETVSTGKFADRQLNYTEKKRKSPKYLQNDGTKHEEYDGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVT4</accession>
    <name>L7JVT4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1876"/>
    <dbReference type="HOGENOM" id="CLU_1157144_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVT4"/>
    <dbReference type="OMA" id="QYEFNEG"/>
    <dbReference type="OrthoDB" id="10302378at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="239" mass="27373" checksum="EFEEA7E33B904D2F" modified="2013-03-06" version="1">MDNVAFVHIIDEHTILGVNSPVKMQYEFNEGSLTKMCRFVDSLSIIVPLSIDSNVILKVIAKILQDSLIENVVVNSPCTLVSMALSMDNLIFIALVPKENSVTANVEAIKNRNVDMLSVCALKGDIRSLSEQICERFCILDDIASLYERLYVYSPEEKLRKNFYTELEKVLNEKTKQNKKITRLSVSTKLASHQQFKFSEKNPIYIGSWLLTKTRFFKTNHFSTRDSFIKKDYTQLSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVT8</accession>
    <name>L7JVT8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyadenylate-binding protein (RRM superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVT8"/>
    <dbReference type="FunCoup" id="L7JVT8">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1456"/>
    <dbReference type="HOGENOM" id="CLU_012062_22_6_1"/>
    <dbReference type="InParanoid" id="L7JVT8"/>
    <dbReference type="OMA" id="CQGVKLY"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="108"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="197"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="302"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="513" mass="58434" checksum="D83006E30665E2B7" modified="2013-03-06" version="1" fragment="single">VGMEKASKIEKTKKENNCTVYVGDLSLKTVESDLYKIFSTVGSIITIKLVKPVMDNFPNYTTCYAYVLFSQEEEALEAVNKLNFFKVHDKEMRVMLYDKERIKSMDRGNIVIKNLSADCDSKTLHDTFSIFGEILSCKVAQNSQGKCKGFGFVQFKNKNGARKALKFGTEMQMDGHAIKVEKYEKNYKIKTGSRAFTNVFFKNFPSTTTEQQLKEIFMSIGKVSSFYFATKPDGGLRGFGFANYENAADAQKAIDELSGKDIFEGKYPEPFYVQQAQTKQQRLDSLSSAFEKLSMSGLNYKRNLYVTRLPSTYGKEEVEELFSQYGKIISVCVGKDNVVNEDKNWAYVCFSTADEASIAVEKGNEVYIDSVKINVTYFKSKNEREQDYINDNMQRYALKTGFRQSIGRPSSFLFKKADTLRYNLQRKTYDKKQMGGDLYGLVLSLAPTFQQKWKNLGIKDEEEFATKITDLLLKRSSTEVRNMIGLGNVLTQNISDTLNDFNEVNCCDGKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVY2</accession>
    <name>L7JVY2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1409"/>
    <dbReference type="HOGENOM" id="CLU_1305648_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVY2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="211" mass="25287" checksum="CEC09B3C1B3D6227" modified="2013-03-06" version="1">MQHTESRGWKEFLKKNCTDASHNGCKYIIYVNFFDFLHEFGLLVSHLMVYDIMKGVTEKKKVIDKITEEILENRKQFGEKHRGKTYYAVWKEAYKISNKTNLTINLEPIQDIMNYLSKECYIIYNNVKKVYTNNQKYLRYRCLDITESYEIAILDMNERQKQFNIPNTNHKVITLNNDNIHVVNRVEYNRKIKADLVRFDQLIKNLVKLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW27</accession>
    <name>L7JW27_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1325"/>
    <dbReference type="HOGENOM" id="CLU_2352424_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW27"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="97" mass="11175" checksum="920F8B17A794DE82" modified="2013-03-06" version="1" fragment="single">VRADALISSMNQRPVGMLDHSRPKDILRTFQVVKVNQGASKKKRQFNTFYCYQKQHLIIKKETLLFHEPSVVEAMVGVPGESVWCVRNREALSKLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW36</accession>
    <name>L7JW36_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993979">
        <property type="protein sequence ID" value="ELQ75246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1809"/>
    <dbReference type="HOGENOM" id="CLU_719989_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW36"/>
    <dbReference type="OMA" id="WYISTAS"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978811" evidence="3">
        <location>
            <begin position="20"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="384" mass="41565" checksum="C21B54C77DFE2EC9" modified="2013-03-06" version="1">MRFTLSNVLVLLGLWVAEAYCAEVIVKIKKQGTEGAGIGTEEQQAKARTIVDNWKELLKESSDALIRQEDSLGKTDKAHYLREGSGEYAVEYAIVLAGLTPNNVFKAFCDRHAGTKVAGRAVFESVLPDPGEGGEEFSIKKDNFIELLKSSIVFTNLLCVPLAGSGIEKTGDERSRYIDWGRTVNIENAFKELTSSVGTNGSIEVSVPAEVYEGFVAAQKAWIESEKRIYTKLTVTPVSAGTKTKKDEILAVLSKETAGFSDKDLLKAMGLNAAEPEGEDQDGVKPFPPRPQGYAAAVPKVAWYISTASAAPKDGAAGKKKEASKSEEKKEASKSEEKKGDGKSGDTEEGWFKKNRKPLFIVGIGLLALVVIAIIVVIVIRMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW40</accession>
    <name>L7JW40_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993978">
        <property type="protein sequence ID" value="ELQ75251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1808"/>
    <dbReference type="HOGENOM" id="CLU_3088969_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW40"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="52" mass="6019" checksum="3EDCA8EFFE64CDF8" modified="2013-03-06" version="1">MIELKSVFMPSILDESLGNVKTDVNKLDIMDCDMNNDELRIMHGKAMREIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW60</accession>
    <name>L7JW60_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1493"/>
    <dbReference type="HOGENOM" id="CLU_3279804_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW60"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4934" checksum="FED2B7C1A9451C7E" modified="2013-03-06" version="1">MRIPPFNKQPFYSTSKDKQTKEYVRDTTIRDLLAMLKVLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW61</accession>
    <name>L7JW61_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ74997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2039"/>
    <dbReference type="HOGENOM" id="CLU_1435381_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW61"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="189" mass="22261" checksum="1787EC6A7F7E8F40" modified="2013-03-06" version="1">MKRAQERRELLFDIWRDKESSSLKSENNVKVKYTYCSLSELKNRLIGHKNRHISHGRPQNTIQRINETKEHEPSNSSTNIPDCTPTKKIKLSDDNDDLPNAQTDIITNFKHEELMSKLREKLMENVGHWAKTKKTNIMGVFYLLMRHLIFVAEPSPEIIADIKVITMEKFYEEGKKYINLVLNTFMRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWI3</accession>
    <name>L7JWI3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1941"/>
    <dbReference type="HOGENOM" id="CLU_790328_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWI3"/>
    <dbReference type="OMA" id="HRTSFIF"/>
    <dbReference type="OrthoDB" id="10330897at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="351" mass="41282" checksum="20FA11FF959F7D5A" modified="2013-03-06" version="1">MYKTRCTGILLCILHITHVLAHRTSFIFFNTSFFIYNYRRLHGDISYLSILSFMVPSLVYHVVELCFIRWCRTNRPLEVLEYVAFLCVFMMCVSRFVDCIFKRSPCIFIVLVCIQNVLTARIGLFYDYSLYEQCFNESVFYNRIVLMVFEEVPVYLSALFMTYTVRVNSFQPYYHLCILLYIVAGAMQCVILLRKEKVLESVHEHVAAKRNVPLFVLCVLCKTNEIFLFLVLTARTENISTVVFYFSIDFLFRLLPFKMPKNALVYLLKVLIVAITFYCIIDQQFFHVYLSLFLFLANGFSNQMVYNAVSNSLMGQSVSDSIVFMLFSVFLPFFAKKYSLRDFIFFNAVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWJ3</accession>
    <name>L7JWJ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1951"/>
    <dbReference type="HOGENOM" id="CLU_1284083_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWJ3"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17003">
        <property type="entry name" value="Actin_micro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="215" mass="24567" checksum="2BD50E77FF95F4F3" modified="2013-03-06" version="1">MSQKGYNIPTVHTITTANKNIHSFFMRTDISYFVKESECYPAYKKDDDRVLVLRMVDDEIEVHECEDSNDDYEYEGEPEDGAEVESNAEAYNNLCNLRIAKSVSKYRVDGLFEGNVLAPVSSTQLLFKLYNNLPCLKDAFVCLVFKDTLRRSELLFLIHVMLNHKSGKGMLLLPESLAVCMSLTLQNALVIHNQGDATYISVVEDYVLTEVKRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWM7</accession>
    <name>L7JWM7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1362"/>
    <dbReference type="HOGENOM" id="CLU_1476147_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWM7"/>
    <dbReference type="OMA" id="FYTERYY"/>
    <dbReference type="OrthoDB" id="10387732at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978860" description="GOLD domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21453" checksum="0894FCA2D205210E" modified="2013-03-06" version="1">MLSLLLLQVLRCSVEIRQIDKDEAILYINKRIEIQQVYLVYNVVKRMTNAIERYELVDDVQRDPNDPQEIFEVSLPRTKPTNYYYGFEVVDVDGNSFYTERYYFGNDRVFYSSKAQVQAEEAADIEEIEEDEYKGKRDKWSVWMIIGIGLLLIFAFATAIVAIIFVYKRIVTSKDKLSGQTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWR0</accession>
    <name>L7JWR0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1541"/>
    <dbReference type="HOGENOM" id="CLU_408923_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWR0"/>
    <dbReference type="OMA" id="EYNAYLM"/>
    <dbReference type="OrthoDB" id="2189043at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="660" mass="75227" checksum="BC5E3BD5C6E8DA3A" modified="2013-03-06" version="1">MSLKQALETNKLPTALTPLLADPAIQQESLELLKQDHTLTFVFLKNAVGLALKKQLNMDVEYLNKIYTTMMDMLYTCNDFNFRVVCQFIEIVAGTIRVRLENVHAPVNRVQRERFLYMLYFIFVRYESATSNDELFEEIDYYVEMTSTFLMEMLRSGECAPLVMNVLHALIYQEMHHAFEDAGLVNELMKCGDNRILGLCLKKYTELVDLEVLLGNALRAKNYELVALVLEKTLDRGTLDREGMRGVRANGNGPDHQINTTSAALGQAEQVRTAVFNEIKNDLVMTEKEKSAVLQDELAYFKDVTSTDTYRGRMHTLLRMLITPENKAVILTCPDTESALFVAAVTKTPVDVLPTDRFSTCTFYRMLLSCRITAQPFNLESVAGRAYSCMKAEHEMLTLDERSVMRVDEYNAYLMRASVWHKTRRGQAVDSAVVENVKAHVMASCAEVSDVKVFWYFVDILELCGAELHDLVERILTGGITELVEIALFVSVKRYCKEKNEHVRTFLLSALERYAEHVPDETKNLVLLVTGNKCAYYERFLAVPGTKCEYVLADDQLVISAPFGCTVVHKEQIVVFCSVHSVDNLVHAARGLLSALEGRNVRLGYERELKRAVHVVQKMDERVGAELRMKLRDVRYGMDLNDRWPLFILDLFCLDGYSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWS1</accession>
    <name>L7JWS1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1273"/>
    <dbReference type="HOGENOM" id="CLU_367300_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWS1"/>
    <dbReference type="OMA" id="ASKHKEM"/>
    <dbReference type="OrthoDB" id="2195102at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="520"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="92289" checksum="4C99DCEAE93564B3" modified="2013-03-06" version="1">MPKNKSPSPKPRRVSFAKKSSIIYIKNEDIGSTSPHNMSIDGGEVSVEITNDYGGYVDGDGKEVGKEVNVKRTSSNRRTSTGKRTSTDKRKLSTGPEASKVATRSDTDQITPKKNQYAALNTVYAHESNNLNGNDSFYACVGENVEDGMQFIGRENVLNTGVAHENAGINDHEDVFMNVRIENVIEETKDKNLIEKEEAVREEELSVGSELRKTRGVFKDTDELINANELKSAKDERNEKENEINLKNKIINDNAPIDEPNEQNSQNEQNGQNEQTKDILINTVDLRKIIRKDDTDLNINERLASIGIRFLDDLMLKQTRKSTLLKTKNTVDDRLYLYYKLYYEQRMAFFVSFLSYIERKMKEHEQLLASKHKEMRAEDFMRIKNAKALKTECRNRTKIRWHELRRTRENVFNARMVECRDGLVEWNRGMEVERERRERERARVRGEIEGLEMRMGQHKGKHGNVDGIVIDDGSNDKGSSNGSNNYSTTTKCNTINSNATNTTNATTLNAYDFTRMKHKIKEQNDLIECLTKEIEAKKNSNAVLKQNIKNEKAEEQALRVTIREMEENARTKTVDEHECERMRKKYLLSAMFYQCEVLKVERDEIEFKFLQFRVVYGDGGVVVSGTVKNEFINFYLRVVNEMVNDCVRGSDCVKDRGSKVIEGSASTNVVSNGNENVSTNLVSNGNDSNTVKDNVNNTKNNSNTNNNYINNNNSNTKSVVTVHPSLVINFLSLISLYYEEILVIERKYFLDMVINDDVHLNVRVPSISNDERDVEILIDKELVMYVKREGEYVKSRSISLLDVIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-03-27" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWW1</accession>
    <name>L7JWW1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative U3 small nucleolar RNA-associated protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1072"/>
    <dbReference type="HOGENOM" id="CLU_931222_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWW1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="1">
        <location>
            <begin position="158"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="299" mass="35193" checksum="F164AFAF03ED6632" modified="2013-03-06" version="1">MIRLRVIMMEKLMVRLIMMKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVHKTDNVNNKENIHRKEMISNKDNVCKKGMIVNEGMIPKTDNVNNKDNILKKEMISNKDNVHKKDKDIINNQIINRNKERINEQNVNSSLYYKENEHPVLILRKPFKTYSQYEQMLNSHEYRRCLTTVLTTNNGLVHRILHHLHVHGVLKQAIFKRNVRQLCVYLCKHIGDVSLKSIALKALVIISTVFERMLVVDRRMLRRIRRAVRHEEYVQKECIRAYASIESVLEDVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX15</accession>
    <name>L7JX15_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCR4-NOT transcriptional regulation complex, NOT5 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX15"/>
    <dbReference type="STRING" id="72359.L7JX15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1459"/>
    <dbReference type="HOGENOM" id="CLU_821821_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX15"/>
    <dbReference type="OMA" id="HIFEGPE"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="224"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="337" mass="40787" checksum="08126F80CA3F82DA" modified="2013-03-06" version="1">MRKAQSPQKAEQKRDQNKQEKSSDSDARKNMELKKDVYKAFDQKKDSMRQDRLAPGIDNKRDLAKAYDSKREFVKNEKNVLITDQKSDFQNFFDTKKDVRLDGQGTFREQNKELPKSFEIRREISKNIDTKKEPFKMAEMKKEVAKMAEQMKCSPLNHKEPLTAAEMWKNAAKLLDSKKVPKKFNFVDQFDKKFVPRGYTRDEYPIAFHQSILYQNTLRRPSQPKERTTVPDFFPKQGIHIFEGPEVYHKLDIDTLFFIFYFSKDEKQYFSARELKKYSWRFHTKYNTWFQRLEEPKLITEYYEQGVFLFFDYEVTWTNRKKKDFTFEYKYLENIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX18</accession>
    <name>L7JX18_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein required for normal rRNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX18"/>
    <dbReference type="FunCoup" id="L7JX18">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1768"/>
    <dbReference type="HOGENOM" id="CLU_691138_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX18"/>
    <dbReference type="OMA" id="HLMMVNC"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="399" mass="46929" checksum="A7C3A56F310BD24C" modified="2013-03-06" version="1">MGGRLKIQKTHISMQKACEELKVTKEQFKELIIHLNIHAESVRSIYKLSCSDANTYSLKDVNKIYNSKLYATIQKNNQRELEKKTWRRRNRNDIADKMRNLDYDYVNIISSKYRSFSDAVADLGETLTFLYVYQFFSSRINDEEGISEIIRAELAKFEKFMIDNTLIKSVYPTKKGLHVLLRINVVEILFFVPLNSNFTDIKRNDFLPYIKLYMYHLMMVNCRMKNVKIDTAKDVVDEREYENEDNGRENAKETKKDSTYNHDHVKNDGKESSNAINIFQNLKIFIGETVLAHWLEILCLCAGAEISEECDYYVTEGKISYLNGSVAYVYPSFIINSYNRRVILDKDEYLVGKEPVGYHYPFESHDKKYDKDFIDTLSKTKRKNVSEYLESIQRNTYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX56</accession>
    <name>L7JX56_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1703"/>
    <dbReference type="HOGENOM" id="CLU_924975_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX56"/>
    <dbReference type="OMA" id="TIKSECA"/>
    <dbReference type="OrthoDB" id="10398053at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="301" mass="35153" checksum="63298EB43149817A" modified="2013-03-06" version="1">MYERLSNLFKEHTKVSQQLDFLRSESKNEEINKTALELVSKGALKDVMVLYGRISNVEIKKSVEEYIVYRLECCIEKNEIQMIKTIYKGIPIGSQLHVQLKNRINEYLLSMKTKIDSSLHFIKISYDLNTDLATNVLFAFFNTFNECLLEMDSWIKECNDIISMLHHKKYELILCTRLFKYSSNVLSSKEVTIKSECAIDEYARTGNKNNITSKAENVMTSRKSQNLFVLKSIYKERELKYFSGCLSGALIKNCRGRDELKYLINKIAKRSMSINVMIKDEMKNMIKELALENEKEFIFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX77</accession>
    <name>L7JX77_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_1133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JH993905">
        <property type="protein sequence ID" value="ELQ75910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX77"/>
    <dbReference type="FunCoup" id="L7JX77">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1133"/>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
    <dbReference type="InParanoid" id="L7JX77"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="337"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ75910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="702" mass="80206" checksum="211D3898B360B858" modified="2013-03-06" version="1">MSSTDPQTLTIKINGTSKQCALNVRPLDLCTREDVTCTVDGVLCDLSVPLTSDCTLKFFTFADSVGKKVFWHSCAHVLGAAILEHSPSAKVVSGPPTDNGFYYDVAVDTPFTEKDVREIEERARRIIKEGRSFKRVWMDKEALLQFYAHNEFKRFFVERSTIGATNDGGKDGKDCDGKDGKDCDGKDGEVMDDKVSGKVTTDEVTTDEVMTDEVTTGKLNEDNKTNKTKTPTISCSCYELGTFLDFCNGPHVHNTRIIKTFEIVKTGASYFLGDKDRPSLQRLYGAAFPSKTLRDEHFAFIAEAKRRNHRLVGQEYDLFWFSELSPGSAFFVEGTFIYNALINFMRREYRRRNFTEVITPNMYMTKLWETSGHLQNYREDMFVLTVDDAEWALKPMNCPGHCLLYARSVRSFRELPIRMADFGVLHRNELSGTLSGLTRVRRFQQDDAHVFCLLVQVEHEILHNLEFMRHVYAVLGFEFELALSTRPKKYLGDKKDWDTAEEYLRRALRTFGREYTVNEGDGAFYGPKIDVVLLDALKRRHQCATIQLDFQLPARFNLQCKTSEGVERPVMIHRALLGSVERFIGILIEHYGIRLPFWLTPRQVAVVPVSNALSAYAQHVRDVLIDYEVRVYDGELTLSKRVRNAEVDGYAVVLVVGEKERNAGTVMVRKCGRAMSVEMLRERLERAVREYVKDVYAVLQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXA4</accession>
    <name>L7JXA4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0974"/>
    <dbReference type="HOGENOM" id="CLU_3144010_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXA4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5906" checksum="88911FADB39C2F88" modified="2013-03-06" version="1">MGQHEMMAMSGTTYYKYGPPPELYDAEAGERRRKRRRERNRKYRAKKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXD1</accession>
    <name>L7JXD1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Sgf11, transcriptional regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1650"/>
    <dbReference type="HOGENOM" id="CLU_2656205_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXD1"/>
    <dbReference type="OrthoDB" id="10336549at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8966" checksum="093C97E74FFB33D4" modified="2013-03-06" version="1">MTHENEPDYKAVYDLILKEYAFNKAFTHTYESNHLCCGYKHKEFSGNIVSNIKCHKCGKYAPAKRFTSHMERCMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXG3</accession>
    <name>L7JXG3_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1636"/>
    <dbReference type="HOGENOM" id="CLU_1138749_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXG3"/>
    <dbReference type="OMA" id="GAIMQGQ"/>
    <dbReference type="OrthoDB" id="10594599at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="21248" checksum="F3ACC2D63FF2FBEA" modified="2013-03-06" version="1">MLFTLLIPHINANMEPNVRLITDGLLFEPVPNQPFDVDLHGNPDRSYYGTMRYDDKTVPIGGVMSGPYDSYAPAAGASYPAPMAAPAAPVSTYAPATGGYYAERPYAEAAPVAQPFIIADQGTSGAIMQGQGQTSGASGATGSGAGKSEGGTGKSSELKDGKSGDKKSSSKSSSKKSSKSSSKTKSSNGAASISIMSALLGVALCVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXK0</accession>
    <name>L7JXK0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucine rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1521"/>
    <dbReference type="HOGENOM" id="CLU_598770_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXK0"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="457" mass="53597" checksum="09B49460E407C6AB" modified="2013-03-06" version="1">MHVNAATIYTTMNIDERIEIVIFNNVNVVEGSTIVFNNNCKQLEIVKSEGSFDLRPYIGIKYYFGYFTELKILPGKKSFPNLSSIKLRLFHFMQTVKLPNIYELIELECISTTEDTEIILNKACKELRIESCEGVINGQEIEYLESLHINFFRNEKDNIRFIGSIRVNKIYITNICWGTFSIISMLTNFKNIQYIEFKDKSLLMFLCYPKYLYNSVIRCITRKKGSKDNSDLLSKLLATTNRDSNTWLEEVLNIILNFVLRNIMGKGVMDNISELELGHFFIDQDNCKSLKELKNLKILRIRTRKITNEFFYNLPPNLILLDITNFAEGEIIDAEKYTIKSSIIVPQHQNIKILSVNVDFLYNVRYLSVMMPSLDILVVQYSRSITDYFPMQKSKIKVRELLITCNYTNEIMLQEEEMILFIKNIKFYIDFELLKYIEFVSLPVSVFFNPDTFQVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXN2</accession>
    <name>L7JXN2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993922">
        <property type="protein sequence ID" value="ELQ75811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1230"/>
    <dbReference type="HOGENOM" id="CLU_2689555_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXN2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="74" mass="8710" checksum="FFD60AD78DBCCE61" modified="2013-03-06" version="1">MEIQRLRIELAGVKKDSNLLQEAIYGVDKLVLQRFKELEELQNKQGCPKQRYHSKDDNQTQQLGERQSLRKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXN6</accession>
    <name>L7JXN6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993877">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3360009_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXN6"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4004" checksum="964E8642DCA9AB91" modified="2013-03-06" version="1">MGTLASWEGSKKKFTHGALLFRGIYIFSLSIFVIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXQ1</accession>
    <name>L7JXQ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993947">
        <property type="protein sequence ID" value="ELQ75537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1508"/>
    <dbReference type="HOGENOM" id="CLU_2905760_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXQ1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7716" checksum="1057003FD5DA18C6" modified="2013-03-06" version="1">MRGYYFQQLYTKNNDYKTEDIKYDNEKISKSEEVYEKKTYLIIKQNKREKSTFGILFLYFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXX9</accession>
    <name>L7JXX9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0694"/>
    <dbReference type="HOGENOM" id="CLU_2279413_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXX9"/>
    <dbReference type="OMA" id="MRHDILK"/>
    <dbReference type="OrthoDB" id="10300186at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="102" mass="12296" checksum="FAE707B8A2CF393B" modified="2013-03-06" version="1">MRHDILKPRSHRKTKLASLPTAVPLSFTRINQKKMRIERPWSRWKRNTRTGIQCRYDREESVLMDRYDGLDEGIKRLAKVEGSLVDVLKNKMRNDELYRNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXZ0</accession>
    <name>L7JXZ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993902">
        <property type="protein sequence ID" value="ELQ75926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1113"/>
    <dbReference type="HOGENOM" id="CLU_1176129_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXZ0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="236" mass="27391" checksum="8AC024FAE385AB96" modified="2013-03-06" version="1">MNILLSIISFITALELRSLVYDNKLYIYPAKRRGTKTLSDFMFERNVGLGVRLKKFVLRSEDHLTVNDFWRILGKNNEELTRKNHILRLVDDKLRISPFVTPVDGVTIFSILLDLLKLPENCYIFLVVDDTEIKEIAKDAIQAFSNVNLLLRFILPKSLVLALDGFLKGRIQKKYLLVINTSGKKSVFSFYTTCKGHKKENKKVSLIRTRKLKIKKRKTNQRKTKEKILTMDTPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY43</accession>
    <name>L7JY43_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993893">
        <property type="protein sequence ID" value="ELQ75981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1056"/>
    <dbReference type="HOGENOM" id="CLU_577703_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY43"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="473" mass="53720" checksum="B82422227817C15B" modified="2013-03-06" version="1">MSCCENKNIRLCLYLCYMNSGIVLPCNLTKVSMTDSVINTSIEMPGVLKVLAFKRVVIKRRCHINVGIDCTSISISQVKGVINIPFIKQYFHLTFSDLWSFELQENVDGTIDVLRISNGTCKSDFHIEQIVHMLNLIDIKCSGKIKLIINNNIENAILTNCSGPINFFNYGPIHPKEFNITCDSLELLKSEKDGPLMKVTISSTTLPDWLDLRTFFYYMRINSEGILQPSSFTIYDIKVQKILLKNCVGNIVCDGNNDSNDPIYREKSFFVFQVLDESINVPQSSVCSISDCYRLIMINVQIYTTLNPQSNIVKIYLEFFEVTDGCIVGIDEAFMSLILANCSGEFKISHALYNSGFMINLTRKDNFIKIERTLEGLYNITIKTIEISENINIPMNADTVQLTNITVSMRFFLLFSGMCNNLEVRNFSGSLKFPNVAGFKRFIGCRPNLRTDSSILSTPARHYEWSDVNFGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY51</accession>
    <name>L7JY51_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0786"/>
    <dbReference type="HOGENOM" id="CLU_336216_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY51"/>
    <dbReference type="OMA" id="ADWFEEM"/>
    <dbReference type="OrthoDB" id="2191774at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="848" mass="98398" checksum="7EF5809734646C48" modified="2013-03-06" version="1">MPILSTTLPLVPTSVKLSFLVRNVVNNTLQSLNEHLDIVNREDLRDYLVHKSKVFKMLAYIDVLKHYRQRKRPPQIADELADWFEEMKMLFCAKCDFRSALSIHFYGYGGVVSNALLEALRDEENGGNAAAERDTLVYTGKRCDNSTSRQVGRADDLSAIDTLIRIYLTKEDVSIFAAVEIQNGVLTLTSEHVTFKLTLCGTHTSPTWTILSPPNVNLPFRLLPVYVKKIGVINRQKRIFEKYKNIAVGTFYDFEIRVFEEITLKIKGGAGVMRAFGEKVGGGLDMNWYVRWIEKWFIGEISNRYEYLKMRYRLWFVIGEGLHLVEQNESAEQAQKDPGGPEGKHFGATSAFYGNDEDGHVTFKSLKEFRRYFVNHERHPFYTALLSVARMNNISFVKNYQEKDFGPRNVFLRRDSNFVCVRCDDDGHRIFVGRNVKYNLLRYIELGMVYNTKDKGAGGTLSLNELEDNFSDLNVRSGCFLTNTADNRHAISLSHVKYFLRDIDLLMMVNDILYLQETSITVSNEIKFVYHLDRYKFKIRIKSDENSRVGKAAQPDDYDQSDQNKKQDEALEMHRAFTRKKFAARIAVNNQNMAEIKMYEISNLLNYLTISILGDKLGKYGIKGAFETVRDRSVLSFMFYNLNIKVVYDGKLSIQCTNTLLVDLLKRCLTVDLISHLRALKLVLKENLVPISFNSNYLLFKYGKRIVFKYYGERYYCALNGGYKIVDEKIVSRMKNMEIGCKMDKIWKCLHAYGKRIGKHTYTWDDAEDAAEECAFVFVTEVGEFRVYKQRKNIILRFTRCELKDEQKIILEKLFYNIFNFENYFTKYMDVLVHRSKAVNVIENLSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYA0</accession>
    <name>L7JYA0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_0557</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0557"/>
    <dbReference type="HOGENOM" id="CLU_769870_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYA0"/>
    <dbReference type="OMA" id="KEFCAIC"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="258"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ76448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="363" mass="42843" checksum="3C3EB7FEBCBD6AC0" modified="2013-03-06" version="1">MDADEQLKQRIADEEEIQNINYTFNDNKHIIHFAALYNNMDLIKKCLSSGVGVDVKGGKYQSTPLYFAVYNKNHSTMLLLLENGANPNYVNLSKNSLQKICICRGDILSFLLLDIYNVEKHLRSRENDKSLKLAVKLRQAQFVNYLKKRNEISYKLVLFFAVIHFISFIYDADSYIIVMLFVSYHNLLIYIKFMFYLNIYYSILFSIELVEYNLACVILLIPYYIAFYRLTRSKTGTKTGDKTEKIKIVREAIRKRKFNEKEFCAICLRYKNTDTKHCNNCNVCVDGFDHHCPCLDNCVCAKMSALFYFYLLYSITLCFVRIVLENSLNTRFNLLVVFFVVVLLFRVYVNLRFLVYRERKRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYB6</accession>
    <name>L7JYB6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0750"/>
    <dbReference type="HOGENOM" id="CLU_2607713_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYB6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9659" checksum="6AF86E3FCE332A31" modified="2013-03-06" version="1">MTDKNKFLHRIVERLQEIEKESRKNLTEKDIEEVMNTISNRLRTTEQKDRMVEMNNIGESYESKVEKPRVFSDEFFKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYJ3</accession>
    <name>L7JYJ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993853">
        <property type="protein sequence ID" value="ELQ76380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0636"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYJ3"/>
    <dbReference type="OMA" id="CTICIND"/>
    <dbReference type="OrthoDB" id="10451301at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="968" mass="112424" checksum="1CA50758520E9350" modified="2013-03-06" version="1">MIPNLYCYIRTVLKYSLRFQTNENLTCDEYMIFDVLDDTGLVNFIDTCRTNTIIKNQSHSVQTLGINNDTNRTDDCDTYMSTYKNTYYVNQGFGTRVIKRRSYDDIIQSDKDVMYEVIDIPFSRQLFLKIMCLSIDYVPMLTIDDIHVILKYVLPFEDKTSLLVYAICEYLRKNKLLIKKWTNWLQGVDETNLDQTEKQIALFVLDKSGHSHSFREIVNSHVVFQIMDSNNESAKTLKHEEMGDLINCTICINDLFALGFLIKYISMNYTYFDNNMYVLDTIFDDDRVWLSLDVRIYNIDLTPSSIIYSAKEVLRKKLFKISECKFLLSKRIRCITLGFKNIRFLFDLNFLGNMNVPISLHFSFCSLDFISSTPKNVENVNVVFRNPPSGTPKRCQNEHTELLYENFVFSEKVYFSSFVKIVKIQNSKIEKNAAISFDEGCEHILITKTTGEIILFNAEECCTIMLLGSNFEYCKRNALSTKILSIDNVEIHGIIRVDGSVDNVSISNAKLSSKSRIDFCDNNKSLCISGTRGSFDLTLYIGLVLYLRENMWIKTIVQQSEVSNSIFLCNIHFKESPKLSNNYSLVELHQITAEKNSSITINEACTTLSISKSRVVIDMTRVKKLYKMRICFSADEVLEIKFIGLISVTILELRDIHKNIDLLKLLANYFSDIRHLRFDNEYNGGRYCTFRNSTINLPSNHSSTANFGTLMRRFSGYLPAEEHNTKLGVSNVVNNDTTLVFAQTSVIQMFSKLRSLEFIKCTTINDDCYYFATMKNLEILKVCIRRLRGDFFNYLPTSLKLLDISNSLAYSYKSGFIRGRLLESQKHQFYNLIVLVIHSSFLPYLHIVSTLMPSLRVLRIFYDSEFSVDSRVINNKLQLCELFIEGGSHLIDFTDKSIKNTQIDSFISLLSKYIYLQTLNYFAFISEDKLLEIDPLTYNIVDRKLYEKFDCHSWKKKYTDMECYWLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYJ7</accession>
    <name>L7JYJ7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0641</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JH993853">
        <property type="protein sequence ID" value="ELQ76385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYJ7"/>
    <dbReference type="FunCoup" id="L7JYJ7">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0641"/>
    <dbReference type="HOGENOM" id="CLU_1653380_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYJ7"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="160" mass="18736" checksum="E21AC0271CFB3F9B" modified="2013-03-06" version="1">MDTVILHLNKKRATFLQCYHHAGAIFATYLFCKAESHVAWIFVVLNSFVHSVMYLYYLISVFKIRIRFKKIITTMQMTQFILGYVLIAFHFIGGLRFSSDLRKKVLEIVTIIFNVGYVLFLFILFKIFFKKEYQKKRDKNRTKVTTSGESREGLPGIVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYK2</accession>
    <name>L7JYK2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anion Exchanger (AE) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993920">
        <property type="protein sequence ID" value="ELQ75817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYK2"/>
    <dbReference type="STRING" id="72359.L7JYK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1222"/>
    <dbReference type="HOGENOM" id="CLU_1251455_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYK2"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="6">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="221" mass="24935" checksum="39D9EDFE0760152E" modified="2013-03-06" version="1">MFDKTDNAYGVNEVLMSSAIAGVVFGLFSGQPLCIVGVTGPISIFSYTVYELMTPRGTPYFPFMCWVYLWSMVFHILIAVGNYISFMRIISLYSCDIFGFFINMVYIQKGIQILSNQFDEVDLASGYASVMIALCMLICGVGSSILGSYLHYFKPWMRKVFADYGVVASVIFFTGFYTLLVVSWTAQRLHDCQSPNHFNQRSQAIVDLMDGLYIFWPGGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYK8</accession>
    <name>L7JYK8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993838">
        <property type="protein sequence ID" value="ELQ76548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYK8"/>
    <dbReference type="FunCoup" id="L7JYK8">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0459"/>
    <dbReference type="HOGENOM" id="CLU_080597_1_0_1"/>
    <dbReference type="InParanoid" id="L7JYK8"/>
    <dbReference type="OMA" id="SNKKYRA"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="17897" checksum="F33F3E71D472D2C5" modified="2013-03-06" version="1">MGISRSNAHKRKATGGKKRTHEKKRKHNSGRAPSNTKIGPTKVKAMRVRGGNIKRRALRLNSGSFTCKSHNITKPCAIVQVMYHPTNNELMRTNTLTRSAIVKVDGTGFKEVLGGEEGFKEGAYYARITSRPGQDGVADGYLLEGAELQFYMDKFKKRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYR4</accession>
    <name>L7JYR4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear transport receptor RANBP7/RANBP8 (Importin beta superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYR4"/>
    <dbReference type="FunCoup" id="L7JYR4">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0569"/>
    <dbReference type="HOGENOM" id="CLU_013781_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYR4"/>
    <dbReference type="OMA" id="CANIMRF"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="821" mass="95308" checksum="A0F61FAD6493D98C" modified="2013-03-06" version="1">MTEAIKHLFQNTLNPDPQRRRESENELQKLVSNKEFVYSLPGTYMKDSDPLIRQVSATFFKNAVIEDLDLDVVNLAVKDPVNVGIYGEIISQHVAKNKEYVVDFQNIIRGDTGKESFDTALLILNAYAERDRTKFSNAATSSLLQSVDPLVFFNKLKNCQDFRKTLSKIFDNYYVPPQLLDVNFLRAAISHALAYTDKHSAGFLLRISTRSFKGLLNCDEIRQDERILNYFYCLQGHDQYKAEYFILYCQDENADRILRQDMLNSLIETLIIPNLAYKDADVHDDLKLKYNYTDDTHNSCSLLFTDILKVSNKQDAILQYMKNLLRSENPKERYVGLSLFVQSEPLLRGSNLYPEFVESVKACLEDPHNFIKSQAFYALQLMDIENIGEDRRRVFNMVLDALKSGDESIRTNSALCLPIFFDAADLRNDVERNLPIILNTLVYNPLNLEQISETLETVIDTFDISCYAVDLCKKMIDSVKIDNIETTPYLRIISDLILSLEEKRDVVFKIYELALPTLFYVLKNKKYDFYTETLDIISNVLYVFKTGDQNILELVRMVLESDQKELINCSEEMTYLLDNYISHCNVSNLDKIVSFVDILCYQEDEYLFDEDFINGCKIIESLILNGKYVAEVNYMEHFLKIVFDNYSKLDNNSLVYGLEILLNALNIDACSGSTRVYSILKPNMDVYIQDMYNVRKRFSRVHDKKIGLLFCANIMRFKDTFDVSRFLALFTHLLYTYDQAEVLRQKIENNEEIDNDAETEYDESDEYLEEDVYFITPLDNINVKSFLRSVLPSLENGTFGYSVFSAMEQREKERVLAIINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYS7</accession>
    <name>L7JYS7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0502"/>
    <dbReference type="HOGENOM" id="CLU_2905758_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYS7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7323" checksum="5C68366766EC99E0" modified="2013-03-06" version="1">MTSIFKRTFYTPHMLNPFFLEYTEALGKTFILTTTTTFLRNVVNLKNRKCIVLIGRRTRCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYX7</accession>
    <name>L7JYX7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Microtubule-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYX7"/>
    <dbReference type="STRING" id="72359.L7JYX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0358"/>
    <dbReference type="HOGENOM" id="CLU_271377_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYX7"/>
    <dbReference type="OMA" id="CETFVRT"/>
    <dbReference type="OrthoDB" id="2195721at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1177" mass="136056" checksum="A6C4CE607EE499C3" modified="2013-03-06" version="1">MKFFVNPQEMSLEDEILSKSCKERANAISKLEKCWLTDKSSYSNLIPTLLKEKNVVVLEQLIPSFKVLPYAVDIATFVIHNFKTPRLKPRVIDYLNCKKKQLDIQLIFDLLDDKNPRFVLCLVSYLIEYYGDQGLPTPEQIEIIKKTFSNADASIRKSSVTLMQILYGRDNTLDLSGLKPIIEKEITEGTVVYEKRNVTNSVNEVNIPKACPDTTTTTVSFVAKADKTLNRDVEKNVEPVKELKVPRDEIPDDKLRIYMESLDDKSWKIRLDVLQQLQNSTYNLQPLTKQICGRLKDPNNMVFLLALSLIKTQRLSFEKETLLHRLSDRKLQEKIKEANIIELAKEDFNTQKNPEVLRMMVEILLYQKNKEFKVEVNQLAGSARKDLRNVVREYVDFCGGRIKPKNEQNAKNAVLEQSVCQKTVKSPINTHNIDKPKHVFDSYAQPTEIVNASLNSNIAEKVTKIDWEQNKNYGLPTKQEQQDVIQYFTDRYLFVSEKDYKQKLESMIKDEERLINEKKLLLFVYSAKEHNKIINLQLLHMLGRQQNVDTFLFCETFVRTFTEEKIFERFMDILHTLSEKKTILYFLTFIKNHKKGKLFECSVRVLKGVIKDCSVDLDILDVNEYIGKEKQMLIELKSFIDQNNQQILNDKQKQHHSEVKRCVIERKGTISDHHVSKSHENDRSVNIKEEVEPDVKVKSSATIDNTTNCTGDKKEAVDAHNLKPLIERSKRKKDGKDFEKHFTENVKTLFETRKVEASDFIIKHIFEEKECLCGRREGTACCLKELISYLAAHSYVLSPYEAEKLVQMIKGEKLLRMMEKIYPKTKIMMLKNEMSNFKNHIGRSFRMREYNMSPLTKKNKVVAENNMKIGRLSIKNDTCIQGVPTFSLHNEEDRNERISLMRSDVREMNNRYYTVTDKPFDNSLDLSGSSIYDSPAGNNSAKECPAPPTGINAPEGSPRSSQKYELFRKSFERRLSTSTPNDCLISELNKKDKTVLRTVYERAKEDIASLFYVANSLITGLISNLNDKTAVDTLMLLSSDKSFLSELDYMTLRMLHVEVIKDIQAKGGDILINLCLNAPVPMLVKVYLNILNLNKEIILKLIWRNSKRKYSSEYAEILNVYEGFFSTDPVLDEMSFKIVQLHVCELVKEVGEKVLEVPTTGVLRKILCGMLERVSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYY2</accession>
    <name>L7JYY2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0363"/>
    <dbReference type="HOGENOM" id="CLU_1620240_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYY2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="164" mass="19765" checksum="BAB576B38285E2D2" modified="2013-03-06" version="1">MLLHDTIEKVEYNEEMLKKYEKDDFLHYLKVISFNIVLNVEFRTSYFGNNTHLEIIKKICQIITQSNCKLPKKELHFEADSIESTETHDLDINTKPFHDKFVQYMRSLRFILSYVDDVSRYKPMLLNFLESNLENESKTEVLKLIYSRVNEFDLDFAFFYRNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYZ0</accession>
    <name>L7JYZ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYZ0"/>
    <dbReference type="STRING" id="72359.L7JYZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0372"/>
    <dbReference type="HOGENOM" id="CLU_150871_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYZ0"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="72" mass="8882" checksum="1496199B5C6D182F" modified="2013-03-06" version="1">MVQLRYKSDKVIEPNFYMRNDGTLTYFFDEEYFKSIVGKLKIVEFMMDKRLLINRKRNLDMYRVFVQSVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYZ7</accession>
    <name>L7JYZ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0382"/>
    <dbReference type="HOGENOM" id="CLU_1846501_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYZ7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="139" mass="16229" checksum="C07BCDE49D45B992" modified="2013-03-06" version="1">MWNALTPNDNVSFFRSSFDDISESKFSVRNVDDNPIVYDQEKFESLSCESRMMNECDPREASRIIPKGRVMELRDVCESRMMNECGPCEASRIIPKGRVMKLRDKYESYIQEAISDKKKLTEWESQHVHPRGKPESNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ18</accession>
    <name>L7JZ18_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ18"/>
    <dbReference type="STRING" id="72359.L7JZ18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0373"/>
    <dbReference type="HOGENOM" id="CLU_1504495_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ18"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="179" mass="21074" checksum="C67B6A64AC2A8D99" modified="2013-03-06" version="1">MLLRDRKLVDLANKNDFNAWDKEEIKDDVLEKALKKVNDDNLCISRNSFEINSKKSWDKFYRMHKDNFFKKRKWLIEEFKDILNRRRILELGCGVGSSLHHFLKINEEENSATSARGESRFDVHGCDFSPQAISIYQQKYKGVFFVHDLISDTPLPAVLMRYFSFSLCRPSSRNTMPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ38</accession>
    <name>L7JZ38_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993856">
        <property type="protein sequence ID" value="ELQ76311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0713"/>
    <dbReference type="HOGENOM" id="CLU_1310934_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ38"/>
    <dbReference type="OMA" id="MECLYYL"/>
    <dbReference type="OrthoDB" id="10251391at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="210" mass="23701" checksum="6CA94465B124D38D" modified="2013-03-06" version="1">MSFCPCIYTKDKNKKKNKKWEEGFVKVEEGKIVLYSDEKRKLFSFKGAISEEMECLYYLIFMENVEDVAKLKNGYDDQERDDGNNTAGNDQVCGNKSNDGATNTSDDITCDQECIRGAYGESFSKKGYDHSVDVIGCNNNAEEENSAGTDGNDRIYITEKATTCKNANKHCSADVGVGQCCDSSLPDTKRLKRDVRRKGRTNEEIWRLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ61</accession>
    <name>L7JZ61_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ61"/>
    <dbReference type="STRING" id="72359.L7JZ61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0415"/>
    <dbReference type="HOGENOM" id="CLU_524958_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ61"/>
    <dbReference type="OMA" id="FECEFKL"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="60101" checksum="718A899BF1932257" modified="2013-03-06" version="1">MEDVFNYFHHTHHPTKHSSGPLGLITAQSPVLEAFLLLPRKMDLERLQAKIKKQPEVYQNEYISMIKTYQSLLNVPPLPDHMAVLQFLVSVCHLYDVQIGKFILSHFRAENDDTRRKEILYLMGSVRRKGLLCRGDFVGAVFECEFKLDLLRIANDTFFDEHAGKSKITGLSEPDSTDKYDSFFLNDVVLSTVEIFKQYYYTGTKSQKKTALFFLIYVYDHTEAKLNGVIMDALKDECVQGLVINYVLGLLTLTKDEPGVKMKMKKKQNRGKKGFDYERFREEQRMTREKAKRDKEKKKDKRKSIADVVVNSMSVEEIVNCGKKGDTSADDMYDHFRKDGAAMKVIRDIDDPKSVIDLLLDQIKGRRDVRSTRLKKLKIISLIKSYFKVPVRINDILLKMIDPSKDDLPVVMHILIRSIERSEARSIVHKINHLFCTRKDDDMKSYGLNLLKEIVLLNRDDDVVFEIRSIAAEFRNCKTKAVFHTYCALMRAIKYGVTDNKSVEYSEKRKKTALCSDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZC8</accession>
    <name>L7JZC8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0218"/>
    <dbReference type="HOGENOM" id="CLU_491925_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZC8"/>
    <dbReference type="OMA" id="MGDYRES"/>
    <dbReference type="OrthoDB" id="10470738at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="431"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="550" mass="61484" checksum="9F3130793DB69C27" modified="2013-03-06" version="1">MSMKRRKLNKIKNVEIKANTSLFADSIIEDNECIGVKCGLSDVVDKKVEDAEKNAGTEVQRNEERGVVDKNEIRATTSPVTHDVLQNEMPIKDRDGENDGPMFERLVINDEYISKNDTMIDILSEKGEGASTGTGTNVSVFCAPLNEQHKKKKTPNKVINSGTMDAVAADPSDVHDYVQNGGAPLICRAVNEADRLDRSDRSIQTRSLIQSVRVTDGAFLCDQQERLAGPDDVTLKRGETSFSGENGILNTNEENNIQKQQSHVISTDRQSPVINEQDAFLRPISCIDDPAGADHTQKGESSAENLKEQTNKTLQLKEHMKKENDYVQENTYDDDGLITQCEASEVLLRLSEGGSDQGRSESARQSTSGECGAQEMGDYRESTSNENDGGYKGIVKGYGAGLADVKRFTHEQNKEAGVLAHGSTHKAFNVIAHEKLRNETLREENAHLKATISEIKALIKMKNQNIGVLEQRINFLECEKKLRDTDHGMIENGLELVDRLKAVYQEEVRMFCRKMERVRQENTVLKGNYDMLKKTVAELLKERRNTKDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZK3</accession>
    <name>L7JZK3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="JH993823">
        <property type="protein sequence ID" value="ELQ76735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZK3"/>
    <dbReference type="STRING" id="72359.L7JZK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0273"/>
    <dbReference type="HOGENOM" id="CLU_147043_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZK3"/>
    <dbReference type="OMA" id="KHAMSSH"/>
    <dbReference type="OrthoDB" id="2194298at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="4">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="131" mass="14210" checksum="43A21D9742F274F2" modified="2013-03-06" version="1">MPNVETALTNDILEIESVLGIEAAQRSIINEIVFTLKSHGIEINVEHITLLADLMCFKGKVNGITRFGIKNFKSSPLMLASFEQTGEHLFDAAANNKCNTISGVSDAIIVGGKIPVGTGDVSIYYNDKQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZL2</accession>
    <name>L7JZL2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative helicase, DEAD-box superfamily</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="JH993819">
        <property type="protein sequence ID" value="ELQ76745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZL2"/>
    <dbReference type="STRING" id="72359.L7JZL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0262"/>
    <dbReference type="HOGENOM" id="CLU_004113_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZL2"/>
    <dbReference type="OMA" id="QGHDKVE"/>
    <dbReference type="OrthoDB" id="2193121at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="210"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="669"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1134" mass="128740" checksum="E6E008BF57E984A7" modified="2013-03-06" version="1" fragment="single">NMQQYSQHLKKCAMSLFAGANTGRVELFRKSSSTKKKLSAKQQQIVKQNEERLKKISEEKDRAFLRNFFAKFKSMTLMQKKMALESVRSDSLVVNRRITLLKIEYYLDKWRIESRKEKVDERLLVDVYVNCLVFFEMGGDTGECAYVEGVMREIGFGATADELLGRGTVVNDLDVYFQLKFAGDKLKRTLDSRRDERTTFMVDSWQKELLDAVDNGTSCVISAPTSSGKTFICFYAIEKAIAEGTRLIFCVPTKALVNQVAADILIRFGDRCKYGIVMPDYQVNADCDVLVTVPMMLEALLENAPCTAHKRAKHAHATVIIDEIHKINSDEMGAYIERSVHKVKGPLVVLSATLGDNNGVYEWICAVERMKGKRCVLVEHAERYCELKNYYYNGEMVRISPLIGCVDKVEKCNEVDKVEGTDNQVGGQGHDKVEGTDNQVEGQGHDKVEGNDNQVGGQDHDKVEGTDNQVEGQGHDKVEGTDDKNSMNKDNEMNLKMKSLSINNNDPVNASTTTRTNATTSPANANLLPEDVLKLYYSVFEIIKDNKALRKEYKALRFKNYFKSNVITKKDVRAYCTSIFTFVKRHGLMARAVELMNNETVRAFSTHSDVSQLNTLISTLKKNEMLPCIVFNMDRECVNAFSISLLNLVQKNEVVRKVTRIKIQKPKGVVRKKDEWIEESAREEEMSNAVVPRDDYMIERISDEELDELVADIRVAPIYKKMLYYGIGVHHNGMNKKYREIVEILFRNKNLGVVFSTHTLSLGINMPCKTVVFAGDSDALDRISVVQMSGRAGRRGYDTVGHVIFVGFEGYRVRRLMRDGESVVKGYSNSVYGWMWGDREYMRSMGKHCFSVLSDGCRSSADEGKSTVDIDVEGKVNNVVDESDNVRDDEGGSIINDKGYNHDNVINTNVNTTANTNNSANTTNDAINSLLWPVIKCSPYKQQIINIFDILVHYDFIKIENGSFYRTKWGDVLLFNEMCDPLLFLVLLRDGVIALNELNAKAFFMVLCHFIEVRWVHAPSKLPILDELPARIQQHVCRINTKYPTNLKITPTHTQLIPPFLHGHPCSTKDAYLYNFFVSGRKGCEHVPMGDLWQICFRVDRLLGSLVEVVDGKSRRVVKDVYEVFRTKFEELHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZN2</accession>
    <name>L7JZN2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoinositide phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZN2"/>
    <dbReference type="FunCoup" id="L7JZN2">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0539"/>
    <dbReference type="HOGENOM" id="CLU_003016_7_3_1"/>
    <dbReference type="InParanoid" id="L7JZN2"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="38"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="542" mass="63273" checksum="6A3C4EEA582E67D0" modified="2013-03-06" version="1">MSRQDPIKMEKQHMLVYENNEKLVIKNVSDECEETLTLSKVLGTGSFKGNNENDVFKCSYKILGVYGMLCLGENSYVIFVTKSAKIARIASYPVYEIREVLIKELLIKNTKGTNDAFLLKRAQDFFKNPGIMYSKFPLYSSNMDPENTDFIFNYNLIGMLKSHVRGSVSSYVIRAIYGSFQYIDFEQFSIVLISRRSWKNVGARFIRRGLNREKEAANSIETEQYVILSGDEEPTNSFLQLRGSIPLYWKQDLTYKYRPIIKIVKTNPLKEYDTKLCKKYKNVFYLNLIQNVGYESGLNKIYISRLADNCLKYLHFDFVRERLLVDYSKKLQLLCLISPQLQRNGFCDSRSAQKGIIRTNCVDSLDRTNVVQFFIAEEVLASQLKSLKLRKDTIPEFEAKYKNMWVKNGNMLSYQYSGTNALGAEVVLHGRQNIKGALVDFYNSGVRYFLNRFYHGDLQTSYDVVSGNYRHLKIAKRKKYFNFSHFFLVFFASVAYSSYYMFDSVNFPRELLVYFLISCFVVPILYPFIARYCFNYPYFESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZQ9</accession>
    <name>L7JZQ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0828"/>
    <dbReference type="HOGENOM" id="CLU_373468_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZQ9"/>
    <dbReference type="OMA" id="RNISWIN"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="744" mass="87508" checksum="FF367A102167ED08" modified="2013-03-06" version="1">MGDNRLKNYKRSGLMLCEYSILKKDLDGLHDSALLGHLLDNEKTARQLSDICLPALNASRIDEILSFVDRNISWINLRPNPCILIDGFCYELRNIYGPVDSNFLLSSRIFQNIEEQETRLKLEITQEIKLNEGLLKIHYEANGILKSELLKPSIICTFREFFETKSTKLAYYRLPLPKTMSILKNSIFTFLNNVYEKLKDTLVVFYSASGGTRTTFASCLYKLLGFKEQLLMKKITNLMDEENGEFSGHHLNSFLNSQICNILGLSIKNTARSTEKARQFYEACDSFKSAIFKDKSQILFCLKLIFSGNLSIINGVQYILDYKFSKHLVDRLLEQFEPYYNLKYALASLLVKEATIYDHKIIIKANIVLEWYMALIFYAEYQCHNTDLEFSAWIEQKKMYHRKFLFLAERRRDFSVFKPVNFKSKFQPIFKLPNLAKDNYLVLYRGTKQTFEIKQDDHKKLQPVSIIEGKHALKNIILLNLMEEPLIYIKGEAYLKRNLISYKNSIKIFESVTYQKLEEIENAIKEGLLERLRSKRCLVYYEEENGDLVRKTISNLHESDIQTPNEYFLSITDSTDDYYRFPITPNFRFKLNNFMLFTKLIKKIDITEKIIYAISYNTKRAAFFCMWIDLVKKNYGKILERRDVVKIYSIRELIRVLDFGYSSLAIVDHLFTKYNGCDFYTHLKTLNDRKTLVIAVKRYFYTICFASYLLSQSSLPFDTWILNRFDICNMYSHIENDVTNNDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7K021</accession>
    <name>L7K021_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">transketolase</fullName>
            <ecNumber evidence="8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_0043</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="8"/>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K021"/>
    <dbReference type="FunCoup" id="L7K021">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K021"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0043"/>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="L7K021"/>
    <dbReference type="OMA" id="ADYMRGS"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000045">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="326"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ76945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="636" mass="71478" checksum="1A7CFAFF9E12B0EA" modified="2013-03-06" version="1">MPLIVMDEKIVQNVRYLCAQVVQRANSGHPGTPLALTPFMHVLYGKILRIHSKKLDHPNRDIFIMSNGHACVIQYVMLVLHGILKMEDLENFRQLGSKTPGHPEIFTDGVEATTGPLGQGLANAVGYSISIMKIRSKAKVYVIFGDGCYQEGISHEAFSLASHLVLKNITFIYDSNNVTIDGSTELSMSDDPVLRFRSYDFEIYEVNGEDLFEIERVLKIEPKKPKLIILRTRIAEGCSRVGDFKTHGAPLGQAVVDELKNGFGDFELDDSVLKFYDEARLKNQRLFEEDTMQNDVIKETYDSVLSQNNERGLDRVRDYVKSTKKMATREHIPHILDEFGEVFRIIGGSGDLTPSTLTRNETDIDFTKNNRNGTYIRFGIREHAMFAIQNGVTAHGYYRAFGSTFLNFISYGFPAVRLAALSRIPNIYLMTHDSIGLGEDGPTHQPIEILPLLRATPNLYVFRPCDGLESRFAFWFAATRRSSPTVISFTRQKVPEIAETNLDRMKHGAYFISKPDNSQITILASGSEVSIALETAVLLGSRNIPTAVVSFLSFELFEEQSLDYKETVLHDGMRVSLEAASTFGWSRYAHYSIGIDEFGHSAKAEDLYDHFGLVPCKLVEQICGFYSNYITSGNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K033</accession>
    <name>L7K033_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993799">
        <property type="protein sequence ID" value="ELQ76970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K033"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0033"/>
    <dbReference type="HOGENOM" id="CLU_2612699_0_0_1"/>
    <dbReference type="InParanoid" id="L7K033"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="8718" checksum="95A5CE997CCC7621" modified="2013-03-06" version="1" fragment="single">VNGWVTGTVNGQELKIEYGTVYIMVYGKAFIVGRWMMERIRNFMVSIEDDTMVSGKEDGQVNGLASGRATGLIGIIQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>L7K036</accession>
    <name>L7K036_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_0002</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7K036">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K036"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0002"/>
    <dbReference type="HOGENOM" id="CLU_256786_0_0_1"/>
    <dbReference type="InParanoid" id="L7K036"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
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    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
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    </dbReference>
    <dbReference type="Pfam" id="PF00623">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="180"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="811"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1051"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="265"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1056"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1088"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ76975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1364" mass="154888" checksum="A546D3CBB382537B" modified="2013-03-06" version="1">MFFYPQRIKFKFPRIKVAEHEIFIPQTLDSLNIPIQGGLQDTMLGPQPHETQCAKCHLNYFACPGHFGEIALQTMIINPLLFKDLFMIVRLGCTKCHRFRIPTNAREHVLKNTGERLVAAMKENVEDRCPYCTSRSRLSKLNLKIVSGTQYVQPFRVYRIVRALFENERSFFERMRVDYKAFFMHKVFVLPNKFRPLNRMNDKIFESAHNIHLSRIVKINQVLKDEIERLRMADEEGKRVKGCLEGEKVEGYVEEEKSENRIKGYVEEERKIKEENKIKGRLEEERTENKLKSEDVKRVKGRLEEENKIKGRVEEERTGNKLKNKERPACKNEQGINAGHGTRDKQNVDKKQKIEKDNGVNAYIDEDLLHILDRADDHSVSVLNGLINALQCAVQYYFDSTEYPSKRKPPGFKQALEKKEGLFRQNMMGKRVNYTARTVISPDPYIATDEIGIPMHIACRLTFPERVTPFNRRRLERCVINGPVFPGAECIVENGVKRSLKYVKNRRAVAKTLLKNSTVVHRHMQHGDMVLVNRQPTLHKPSLMSHRVRILNDKTIRMHYVNCNSYNADFDGDEMNIHLAQGLMARAENAYLSSTHENYALNGKPVRGLVQDYVVSMFSITLKDRFFSRAEINELLIASRKLNFTITSAAILRPKQLYTGKQLIAMLLSAYDLRINYEHANKISTLYWKEHREESTVRFHNGYYVHGVLDKSEVGPSKNGLVHCIGMLKGYFVCNDVLTALGRMVSRYLVCYGQPLGISDFVLGRVYEEARARIFREGVKRGDKVLRDNMGDDCDKDEGCDSMGRGEDCDGMGRSDDCDGRGKDSVTDKGSNNFNISNPINTTNNIYPITTNLTNPYSTPMVVIPKVTLSKNERINLDNTIKKEMHTVTSQVSDLLIKGIETPFPSNKMANIILSGAKGSIVNFSQISGLLGQQSLEGGRVPLMSNGRSLCSFLKSSVLSGGFILDRFLTGLSLSSFFFHCQAGREGLIDTAVKTSRSGYLQRCIVKMMEGTVVEYDMSVRDGMLIQYVYGEDGKDPNRMVNERFMTMNGGLIRDGSNDKDRCRGSNDKNRDDDRGDDKDKNKDKDTNINTNTNANTNPINTNYINQRIHPGESVGMIAAQAIGEPSTQMTLNTFHLAGCATNVTLGMPRLKEILMIGNKSINTVIKGKITNRITFDPSTVLLKDALFYYRVVERNETDVLFVLNRSVGNDTVIRFKRMFLKEVNRCMGKGAAVHEMINNNKDGDSNDGDGRNYDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVHGQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K084</accession>
    <name>L7K084_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="119" mass="14349" checksum="32D25B6FACC9EFB9" modified="2013-03-06" version="1" fragment="single">VLFEIDNCVYIQKWLLQYLGQEERNAKFMNVHLLDRAYWKLKHKIFRKIKGVSFEKWNSIYLEHVKMYSAWLEKMILERPKKIDEFMKTYGISTPTRDSLFENLCQGKVDLSILGENII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0C3</accession>
    <name>L7K0C3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0C3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0087"/>
    <dbReference type="HOGENOM" id="CLU_3070357_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0C3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="53" mass="5664" checksum="96C7A0C860EFB173" modified="2013-03-06" version="1">MAEEPAMQVRTAFKQSESDMLACHQAVNSVGKTLLPKKCPLCGSQGLATEPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0D0</accession>
    <name>L7K0D0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0D0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0107"/>
    <dbReference type="HOGENOM" id="CLU_492726_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0D0"/>
    <dbReference type="OMA" id="ESNCSFY"/>
    <dbReference type="OrthoDB" id="3158924at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="69063" checksum="F15DECA165F4AACB" modified="2013-03-06" version="1">MDSFRIIRINKNPRDMKEILKIKRVVGCILKEDKVFLRVLWEDKLVTWESPDTLCCPLLFTNFLNKVDGLLQKKAFEEEKIRKKEAEKSFISSIRSKEPVQEAKTIHRVVTSERNKVDCHQTKTTNKRTEEPELHKKYKSLSIANQKNARESARLEKYGLESFGQKSSFGLHKPQFKVSNKTFLNNQRYFEAPQSKPASYTEKKEIEIQSKENDFVVQVDSQKVATFSYVNIVSNLTMPFNKHFNVTHTVSLDELENIMFSARQNAAFGNFDVYNLKLLNNNGRFRDLLQQAKDNHVFVDVTSSVSFVLFFVFNSSRLRKYDICGYYNLVRLPAEMVKYVIDARIDRSLCDSYNLWQKSTVHYADRVLRYFLVCSPNLVEDKIHRFSIFANSSNFMASEIRKFLTSRGKKYVTMEHTEIDTVFIHVEYLQFLNNMPFYFSLVESNCSFYFFGASIIKREGYFLAPMLKEGGILLLLDSFSAQINDQYLSQVIAFLKKDNLSKWQLIVSSDLVCILESMLCQTPNNNTIRNILFLSQNSVVKSDGFVPEEHIKNLRKKNLLEKRYFYIIDPKQNDNLHKTPKQLLNIIDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0E8</accession>
    <name>L7K0E8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993800">
        <property type="protein sequence ID" value="ELQ76966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0E8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0042"/>
    <dbReference type="HOGENOM" id="CLU_1998097_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0E8"/>
    <dbReference type="OMA" id="INSRVWK"/>
    <dbReference type="OrthoDB" id="10293110at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="125" mass="14691" checksum="973CA7A36808FCDA" modified="2013-03-06" version="1" fragment="single">VIKPSIIVVQYKNLKVLRVEAEFLHNMRSLSVLMPCLEVLEIQYSPSVKDNSRISVEKIRIRELLIRCDGFDRVHRHKIISKKNEMIGFMNELKFYIAFESLECIAFTYSKTSILFDPKTLQIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0H6</accession>
    <name>L7K0H6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993818">
        <property type="protein sequence ID" value="ELQ76747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0H6"/>
    <dbReference type="FunCoup" id="L7K0H6">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0H6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0256"/>
    <dbReference type="HOGENOM" id="CLU_140546_2_0_1"/>
    <dbReference type="InParanoid" id="L7K0H6"/>
    <dbReference type="OMA" id="RPINYGQ"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="72" mass="8760" checksum="18F65C4041B1037E" modified="2013-03-06" version="1">MKPQKVFYSDPYETNDYIYRHVIIPKSTVQSLPEKLLNESEWRALGLEMSVGWEHYMIHKPERHVLLFRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0J2</accession>
    <name>L7K0J2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase 2A, regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0J2"/>
    <dbReference type="STRING" id="72359.L7K0J2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0181"/>
    <dbReference type="HOGENOM" id="CLU_1428925_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0J2"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="190" mass="21633" checksum="809A509B12F73538" modified="2013-03-06" version="1">MKDSVLNLINIKPANLDNLGSVITKCTYFSFDTFLYALSSGKIYLNDMRVCLQSRRTHQFSYQPDNYKEILSAVSDISVVDDHSFVARNLNTVILYDTRNDRSCVSTYEVFKADAKSVQRVCNLELVYERMHCVYEDGRIVTGDFDGNFYVFGRDGERVSVKGEGVAKVIGCRENEIVVCGESICYYKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQV1</accession>
    <name>L7JQV1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec5 subunit of exocyst complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3288"/>
    <dbReference type="HOGENOM" id="CLU_529991_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQV1"/>
    <dbReference type="OMA" id="WINTCVE"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ73809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="567" mass="66172" checksum="CD13882D1112DD7D" modified="2013-03-06" version="1">MSDSVSSETESSDHKTHNDVFLQEAFDPLVFINSTMNEKTLGSLNDTLVSIKESINRNKIKNQELVRRHFSKFVHCRESIEEIRRNDAFSYVKNVFEQIEHNLTTLRNRIREISSSYGISAHSSDENVKRAQIAQHYNKLINLEQRLRYDLKYLDYEGFVKHYNSALKLKNDSKFLMEKLKAADAVKNRFLDILMAQIEKNGCADDTLFYFKLYFKIERDEHNKMENTLLTLVKKYLNDKKGLVEIESVLIYILKNLSIVKTFLIEQHILDSTVAWINTCVEREFSVVAYRMAISRLRIFYGLISNIVNKGNLGAFRESVDEIKNAMTVRIFSEMGMLFRQDVDNGGNTLDGLLVSLDEFVKLNDIKENLYVVLENMLRAKQRSVSNDKSNAMDNDRSSAMDNDKSSAAVHGTSNIRVDYPYKSKQACDNDRSTKAEIDYRYFLQYSSKIINARTKLCQINRLLNNTMNFKRVDKIIKKCETETIREFVKNIPNKSTEHVLMTLMKLKEMYFLSKETLEFLDPEILKCKILVFFLCDILEVDEPELSMQERNKMNEIYAQFSSLRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQY9</accession>
    <name>L7JQY9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3205"/>
    <dbReference type="HOGENOM" id="CLU_1066291_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQY9"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="261" mass="31464" checksum="E685D95CBF027ED3" modified="2013-03-06" version="1">MIKEKLQKLQSLKKTSDLYTKPLFLLQNTEHLDIDTHRDMLCTDKYIKRNQLRETYTEQQEKKFNRKYSEYLKALVKKRADDCFGVLIDFHIKFYRIDRYNRNELIFVLLPDYQIYERELGMLGVEPSWCGIIREMTNRQFYYLVMEYHRYDELFFKRLMYSFLESNEKLPSFYGLAALRAAKKMKDPVFLRYVYLSFKRKAGIEVKELETAVLHDAIEMDEEKVLKGCDGQHEYISVQDVNRKQDDILVQCRDAVTETNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQZ8</accession>
    <name>L7JQZ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Queuine-tRNA ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQZ8"/>
    <dbReference type="FunCoup" id="L7JQZ8">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JQZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3176"/>
    <dbReference type="HOGENOM" id="CLU_022060_1_0_1"/>
    <dbReference type="InParanoid" id="L7JQZ8"/>
    <dbReference type="OMA" id="CTRFSIN"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="3">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="3">
        <location>
            <begin position="252"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ73898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="542" mass="61186" checksum="43751641BC677B57" modified="2013-03-06" version="1">MPFKILKKCSKTNARISTLTLNHYTASLPTFMPVATHGILKAKHGYEDEIILGNTFHLRNLNRDLHSFMGLKGGLLTDSGGFQIISLKNKVNEDGVVFLDYDCDGKRIGGKKFNRDDGGNDDDNRSNDNNEGNDDENESISNDDNNEGISNDQNEGRGIDNINENDGIDNINENDGIDNINENDGIDNINENDGIDNINENDGNTGNTSGDRNVNIENNANSKYCKNVYCLNTTCIGCSFIPSQKAKYFARTISHHYKNFLLTPEKSMAIQNTLNSDIAMQLDDVIRPCSPKNRHLLAVKRSIRWLDRCLAHTKNDAQLLFPIIQGGLFNDLRMLSVDEIVLRGVKGIAIGGLCGGEDKKMFCNIVFNTVNYIRSKIECPIYVMGVGYPEDIVVSIFLGSDMSDCVYPTRTARFGRMFTDYGDINVNSFADGNDAYRGRSSRRNDTQAYTNTRIRDGVVYNECACRTCTRFSINYLKMIRNTPNFCILMTEHNLFYLRDLIDRVKRNIRGGTLDIFVKEWMMKRFGGKVPDWVKYAYDLVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRD3</accession>
    <name>L7JRD3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoside-triphosphatase, RNA helicase</fullName>
            <ecNumber evidence="7">3.6.1.15</ecNumber>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_3087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.15" evidence="7"/>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRD3"/>
    <dbReference type="FunCoup" id="L7JRD3">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3087"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="L7JRD3"/>
    <dbReference type="OMA" id="FYTREPE"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="120"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="293"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ73994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="700" mass="80570" checksum="C8F2F16796D86A44" modified="2013-03-06" version="1">MDEQKISYFIKKDLNINDQEVIEYILFLIKQKRLFEIEPLLQRADFVKLIDILCDDSKHKDIYIKRDEPHFLRKLKNIEVTNNHQIPLTAGVVRKINTNRPVKYRMNADLPVYAYQKMIIEALEQNEVVLIEGGTGCGKSTQIPKFLLNYFEKIVVSQPRRIAAVNLAKRVSLEIDERLGHTVGYKVRFGEKSSDRTRLKFVTDGILLQEREKYDLVIIDEVHERKLNTDVFFAAMNTYRYNRLILMSATVNSYKFIDFFKCANVVIEQRYFRSDIHYLPSPCYDYVRKIIDQLKALLSNAQANLNTLVFLSGMQDIDRCFNLIKGQGFEKTVVFKLHSSLSFKDQQRIFRKYNESKIILSTNIAETSITIGDLDVVIDSGFVKQKRMEGGIERLEMIRISKEQADQRSGRVGRTKRGVVYRMYTQAEFSAFCHENTPEIMNANLCSLVLAIKSLGIHDIIGCRFLERPPLENFTDALERLYRLKALDDGGSLTALGLKIARLPLEPELSIALLKSFQLGVFTEVSTICALLSVQNIFNYTNIEEYEEIKKKYGDCTGDLFFLMNVYHAVIKQGERHAQRNKISFKAIIEAKLIIEQLHSLFGMHGAKVIQGDYLGRRARIIKSFCAGYFLNTARRAGASFKMLLNDDEIRVHPSSMLNASNSEFILYTNVVFTDKTYAKNCVKIGREDLLEASDMFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRH9</accession>
    <name>L7JRH9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clathrin adaptor complex, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRH9"/>
    <dbReference type="FunCoup" id="L7JRH9">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3207"/>
    <dbReference type="HOGENOM" id="CLU_1866662_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRH9"/>
    <dbReference type="OMA" id="NYEEAYY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="141" mass="17039" checksum="F60045395690E54F" modified="2013-03-06" version="1">MYTMINTIFLCNSEGEYRIRRSFTLEKIDLRSAFKTKLALRNFFRFEGKLYVVKTYKLVKIVFVVEHENPFIIFYYIDSLFQLLNAYFSGFSDSNLIYNYEEAYYMLDSMFLDGKLIQNDREVILKNTRAFFRRRGVPKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRK8</accession>
    <name>L7JRK8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994075">
        <property type="protein sequence ID" value="ELQ74108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2971"/>
    <dbReference type="HOGENOM" id="CLU_063261_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRK8"/>
    <dbReference type="OMA" id="CINENCI"/>
    <dbReference type="OrthoDB" id="2186004at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="249" mass="29279" checksum="0AB968FA813D6902" modified="2013-03-06" version="1">MEYNLYNPLKTDEKSSEVEEKKRIKPNKTRKSVLDNISYIETPISTDLKNFIMEETGKHYEKVLPVIERLCTDHVGTDLYERLNNELLPFLGEDTKKFVGRLLFYKKRSCRDGNRCQNLKNCIFIHDVSDEVIFNRVPSAFSDPHVLEKYAKEYGNVFSIKMLNQQKFLVKYDSVQSALQCINDQAPVLGNKEIKKFFNRRRVDVKDLFREHDELLIALFAKGEKKFAMRLKNVSNRIKEALENSRKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRV4</accession>
    <name>L7JRV4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP:ADP Antiporter (AAA) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRV4"/>
    <dbReference type="STRING" id="72359.L7JRV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2896"/>
    <dbReference type="HOGENOM" id="CLU_514084_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRV4"/>
    <dbReference type="OMA" id="FLAYSPC"/>
    <dbReference type="OrthoDB" id="10384464at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="562" mass="65333" checksum="30AF111AC08C8DE3" modified="2013-03-06" version="1" fragment="single">VMKRRIHMAKPGTFFDSFLSIKKYLNRELRRDMREEASEGAASSLNTSISSNEKKKFYFKKMWLCALMVYLSYVLIYSSRNLLNGIIIARQRPIAKCFTITFIILPITLIMSVLVRKWLSKYSIQRMMTYALGVYCLYFLFVNPALIYFKKRLDVNEFLVADLIADGKVAYKRARFCEILFCALTSWTVTLQFSMINIYESFVQYVLMFSVFNEIFTQKQYNGFVSIIVFCETVSLLTSSILSLMHQQIIASVEYYNKEYVNMTFSGISAALCLTLFSIFAYLRKTVESGRTGSLQRSNVVLHVETPEDDYDSVRDRSLLSLLRLKFVRAISINVITLFILNEFIYISFESGVYTKAKKTFKHVTSSVIKSTDIIRIVSALLILLSLLMSVPRWLIQNNWKFLAYSPCVWMIMVSIVQFTMDTILKGVDNDGFQFVSRAFQSLKSDKNVDLRRCIYGIYNTFTITALIIVRYFRNIGFLITKETLTMMIDSKIRPRLRTIYDGMCPLIGKAIASCVVLFTSELLNFSDARSFSIVVLVFALVVFYFWMKNTRYLVKRYYELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS22</accession>
    <name>L7JS22_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_3221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS22"/>
    <dbReference type="FunCoup" id="L7JS22">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3221"/>
    <dbReference type="HOGENOM" id="CLU_006451_4_0_1"/>
    <dbReference type="InParanoid" id="L7JS22"/>
    <dbReference type="OMA" id="RYWDASD"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ73846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="673" mass="77307" checksum="91E0CBBC08802DD1" modified="2013-03-06" version="1">MFILCLPSLIQSFQLSAEKANTLSKPTKVFTPTPDTTHDMKTFEGNFTASGPKNMNDLVKHVSTYTDFNLLLAAQLFLPNSDSKDFVDRPTKRPIEKISHDFAKLQKELGIDRFVITEDDYDVKNDFGTLVAYVMKLRPESTDAAKVHALQKFIDENFEAPGSDLTEHPLEDFQSEPPFLSSITNENMRDVTLELNRMWKELSRVAVVKKGHESTLLNLPHPFIVPGGRFREFYYWDTYFILEGLVVSKMDKTASNIIKNFMHIIDTLGYIPNGTRKYYMYRSQPPFFPLMLLKLLDLNDGEYNDLILGKGLEMALKEYDFFDKYRSVLVKGRDGKLHKLNYFHVTTDFPRPESLSEDMHTYLSQQKLSEREVYSNLKSGAESGWDFSSRWFKDESDISTINAYNQIPVDLNAILFRDEQIISTLLKRAGKHDEARKFGDLSLRRMEAINQVLWNKDVNSWNDYDTENNKFVARRFYFSNVFPLIMGVEPPTGNIYNVLQAYQRELFSYIGGVPVSGPGKDTGQQWDFPNVWAPHQFLIVEFLYNKGEHKMALQIARAFYNSVSTGFKQKGVFYEKYNAEQLGFTGEGGEYAAQTGFGWTNGTALSFISKFKDQLAEAYDHQKEFKEIVELLAKKVNNENLGPANKTNVKGEKKPNLNVMFDIKTKANPIEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS32</accession>
    <name>L7JS32_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HORMA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS32"/>
    <dbReference type="STRING" id="72359.L7JS32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2996"/>
    <dbReference type="HOGENOM" id="CLU_1066290_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS32"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="261" mass="30023" checksum="FFA3D5477E0717BB" modified="2013-03-06" version="1">MQEQETLQLQSLKSTLLHITTQRKMFPTTNPGPRNRFLCWLNNGIRDALSKNYLHQIILTIYTEKNRPDAILESYTITVTGKLCEKRPDKDIADVLKMLAPLPRTRYLSMRLVYNETCPDEYEPVGFKRADYEYVMNGNEVLVKDDIKIESRLEINKEKRDEIVDLNDTNGARNERVVVDDKIIKERGRGNEDMAERHGCCHPTNNGDSNEERKTEQKNSSATTTANVDVKARADSNTNICAINNSNVVEDKHQKGEYRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS59</accession>
    <name>L7JS59_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2826"/>
    <dbReference type="HOGENOM" id="CLU_1687968_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS59"/>
    <dbReference type="OMA" id="YYEFKYK"/>
    <dbReference type="OrthoDB" id="2191506at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="156" mass="18219" checksum="35C33D56C49CCC3D" modified="2013-03-06" version="1">MRRFAELVDSNVFANKRIALVENGYTDVTFMIEELMKIMNLQKLISFYKNKTYYDHISADINTIFESQCAFTNNTIVDDFYTAYTLFGAIIEHGVCVYRSDSFDYKWTRGFDLLIVVSPLESGFSTVYDGTIKIMDRDIVYYEFKYKVNESIGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS97</accession>
    <name>L7JS97_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2716"/>
    <dbReference type="HOGENOM" id="CLU_1235854_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS97"/>
    <dbReference type="OMA" id="TCYRDAF"/>
    <dbReference type="OrthoDB" id="10317248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="224" mass="25469" checksum="73B08516200AD719" modified="2013-03-06" version="1">MADVEPVFRIPNYLSEVGYGSPFTLIGSLFFEFILLIALYIPIQMLGGFQELLLAGGGMYYMTLHILSYIPIPLYFISASIAFLIMIAVMVFSKNEKFYNLFTAIGSAYIVTYMIVILLNMPRIFVFLPLMIVAFLGFVVFKKTKRAMHYAVCKAILTGFMLDLMIDHLLPVAYMTKSHFSGTALMYGNNLLTIVTFVLAGVMSFIWTCYRDAFMNKVKSFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSD0</accession>
    <name>L7JSD0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3157"/>
    <dbReference type="HOGENOM" id="CLU_3337994_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSD0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="38" mass="4508" checksum="EE28EA57F039E8B7" modified="2013-03-06" version="1" fragment="single">VAVAMLGPSELEEYFVMQCDVRINKEFLEKRKIIIFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSD4</accession>
    <name>L7JSD4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994064">
        <property type="protein sequence ID" value="ELQ74190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2890"/>
    <dbReference type="HOGENOM" id="CLU_3320316_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSD4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4226" checksum="6456A7F04BF5D3F0" modified="2013-03-06" version="1">MNVIYLKNDELILTKPVAMVSPSGPEEYVELGELSSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSH3</accession>
    <name>L7JSH3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Maf1 regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ74001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSH3"/>
    <dbReference type="STRING" id="72359.L7JSH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3094"/>
    <dbReference type="HOGENOM" id="CLU_121572_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSH3"/>
    <dbReference type="OMA" id="VICIQNT"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="193" mass="23060" checksum="DF3D373662B1DD15" modified="2013-03-06" version="1">MESLQRKALKTNLMLPIRSFYDTVFFTNSTRYPLMRYLEMNLISEANAIFNQLEAKNFSINLEAYSCKYTKKQRKRQNYKNTMAHLINTLELANLKGKCKLKKEDFKLKQFSEIKNDIFLILMCNNRFDAEKMIRMLVICIQNTVGINNTLIFSLENRIALLSDDKHFLCYLFYNRKAKRILLLTIFYNMNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSL4</accession>
    <name>L7JSL4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994082">
        <property type="protein sequence ID" value="ELQ74041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3043"/>
    <dbReference type="HOGENOM" id="CLU_316465_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSL4"/>
    <dbReference type="OMA" id="IDTEHRY"/>
    <dbReference type="OrthoDB" id="10459486at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="922" mass="102544" checksum="0A69BB0AB81121AC" modified="2013-03-06" version="1">MRITKQLVNKVNKINEHEDEIGTTLKQSSLVENNNMKTKDANAGNTELIEQTTNSPSLNQPLNTTPNASHDFPSAASSINDLRKTNLVATNTSDPNLVADRIPDASNSLPKNSSIATEKSLLNRGVRLAVNSTGSTNKQTTLNKSNLLDVNSTGNLQSIPVNLKQNNLNEMVTPSLESSAMINVGPPVENTKVIVQEEVPRDNNPTLIQLPAKPFVASDDSRQKILVVDPPVTPPIPNDINRTNNDLLAQLVTLIGNIQNPNTVVRPISNAGDGIDTEHRYLTNNIANDNKMNYSDTQCKNDVSCMQIKDLQMGRNNQNGAEERRMRNSDPCLFYKTLVDYTKDINFLSPDMKKELNRIKSKFVDRYRTELKTCLGLADEIAEVRTRYATTTRGFLDGIVDFFKDNGTNGKRTDRPRLLFDEINNINGLGGSGDRDERNRNSNFLENREGSNDDITITRYVTLDNDDKISIFGNKTITKTVTVSKDPKKEAERIKSNNQIDKQISKRDIVQDYSPEKKENKDKDSTLSKNMQDDSAEMKTTNESQSSSKTSTGLETSTAEKTSTVTKTLTKSTTITITQDVSHSYSSVSKTPEKTKSLSSDSPSLSASISSSTDVSNTSVKITSDDGLDVLSFIKKLDSKNYTTTKHANDNKILESIYSIIIEIKNDEGVKKTKKYEKATQYSVKSTEMMVSTLTITQTVDKELIRKTNKSLRDTTGPITETITQSNTPSIDTIAHHENILKEIREDQKILIEKLKNILDEGQLQEFQKIQPSKPKIFESIYSTVDVKNIKPAVENVKKSIDAFKNEFNIAKDINIEIISEAPSIGSSTQTFSIPGEIYSSIMTNDKNERALYGSDTETVSLSQSIEVNKTVGQENSMQYYKTIVLRHKSSENDNEDVKIKIEDQSESNSDVEKVIVSGSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSR5</accession>
    <name>L7JSR5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994046">
        <property type="protein sequence ID" value="ELQ74340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2748"/>
    <dbReference type="HOGENOM" id="CLU_3279806_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSR5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4489" checksum="1C10FEF1243BE017" modified="2013-03-06" version="1">MMIAAVKEFVVGLRDWGLRPAIEAGSAPEKQRMRSGRGPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSS2</accession>
    <name>L7JSS2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rho GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSS2"/>
    <dbReference type="STRING" id="72359.L7JSS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2574"/>
    <dbReference type="HOGENOM" id="CLU_1008970_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSS2"/>
    <dbReference type="OMA" id="IMEFFLT"/>
    <dbReference type="OrthoDB" id="2192550at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="81"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="276" mass="32704" checksum="E5BA4A4349E06E16" modified="2013-03-06" version="1">MNESYINQRLTEKQLTVNDIDDEDVRAYLENFVEENLNVLRSVFSVIELRTIPGANYIPNVYKFKEFSRENGELQPTRLKYSYSELYIPSELNEIMEFFLTLDLTQRGIFKRSPSIVIVEAAIKDFEECMRTRSSIHEKLARYDAITIPSVFKNVFNYYEMPLFPKEFVDYFCRIKRLPRIDDQHTALKFLLLCMPRTNRSTLEAVIRFIEIVHELASQKDEEHQEHMDFSGFVSVMMPKLMLKSNIRVRLENLKDLIDMLLIVFRKYSCFVGVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSZ7</accession>
    <name>L7JSZ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ca2+:Cation Antiporter (CaCA) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSZ7"/>
    <dbReference type="STRING" id="72359.L7JSZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2669"/>
    <dbReference type="HOGENOM" id="CLU_606943_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSZ7"/>
    <dbReference type="OMA" id="FIRIAMA"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="270"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="428" mass="48501" checksum="DEEC93222F332A09" modified="2013-03-06" version="1">MGIINTFYDLPVPFNYAAVLVLNMFMLFSGYLLVDEYLMQYLDNAVKQTKLQSELVAIIFLNIGNGLPELITGFLCGQKDLLCAIYCSIGGMLFIITVVLGSAILFKSKTVEIKNSLFYKNIMFLFLSYSLLTCILIREAVNIFIALFMVGTYAVFLVHSVVNNRNDTEEIETVQHAVGSNKYRKVVHWCLYPLRKLFDISLINQKATSTPLALYLCSVFANFIVFSYLLGCLSKKVFFIAVPVLLLLSAVLYFFDTITPNKMIMNCYSMFIAILWIFFTSDTIVNQIEMVSERFNMSKELSSLVFLAFGNSFADLVTNSIAARKGLVKTAVSSSMTSPIHNILFNFGLLLSYFTLSNGTIVLHSVRNAMFTVFPIVFVPIALFIISFNYEIRNRKLEIELAYTLFVIYGLFICLLGMEFYLGDYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSZ8</accession>
    <name>L7JSZ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSZ8"/>
    <dbReference type="STRING" id="72359.L7JSZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2517"/>
    <dbReference type="HOGENOM" id="CLU_557800_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSZ8"/>
    <dbReference type="OMA" id="YKEYLMI"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="516" mass="60769" checksum="F96C8D0F860AEDF1" modified="2013-03-06" version="1">MSIFKKILSKKETFFSTKKLIYTAPAYEIFTYNKNNETLSLIKYTDKKDAQRIAKILRTVKHYNVMNVIKSKDCCIYTSLVVPYRMLGDNLSNTYKEYLMISLANALQFLHEKCKIVHDNLNLDALLINSQGALVLSGFECAKVQNGREECSRDFELFEQLSYSLLNTRMRYDDCLNKENFYSILAEKFVTFNVMGDDEIVGLLNMIRREHKANDIPEMIKMHICRLVTNKMVGLTKEKDEKAVVDLSELEQQVIDGHIEHVFFLRFTFLYFMISLEMESYDIVIEDLFSVLDTKFRVEVLKKRNFFMKRVSCWDRKSIFYNLTIGLKCKDKALQTLTLEFVNDTVKFYNFTEIKELCKLLSHCKCVYTLIMIENNLKLFLDNDMHGLYKLMFVFIHDVHTREQSLILLDKIYKNFSFKKLSTEILPFLCELIVETDSETLFMVIKNILGYLESNREAIANSKITTRMTRWLPFMSKKGGGKDDEKQKKFMEEQPSVTEKDVDSSMKKNENWDNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT13</accession>
    <name>L7JT13_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin complex component, TCP-1 theta subunit (CCT8)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT13"/>
    <dbReference type="STRING" id="72359.L7JT13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2634"/>
    <dbReference type="HOGENOM" id="CLU_1003113_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT13"/>
    <dbReference type="OMA" id="KIRICKV"/>
    <dbReference type="OrthoDB" id="2194232at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="278" mass="31561" checksum="FBE66D1D1591C768" modified="2013-03-06" version="1" fragment="single">VHGMFLEKALQGTIKKSGGKIVIFNTSLDIERTETKGTLLFENAEDMLNFSKDEEKRMLCLVDSISENVNAVICNGNINEQYAEFFNNNNVMVIKVNSKFDIRRIMRMSKGSLLQTVRRPRREETGEIDSITTVYDEGKTYLRLEKKDSNIVSIVLKDSLASNLDESELLLEKGIKIMESLRDEDLYFVNGGGVFEKQLSDRLAEKSTNIRDSSKLVYSAVVKALSYFCPPDDVDTEQLKDIYSVKQRALEYAFDLACEVLMIEDYLVAKNEGPEANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT16</accession>
    <name>L7JT16_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3175"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT16"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="959" mass="110077" checksum="3204803C88CAF90B" modified="2013-03-06" version="1">MFHQLFNHIDRALVTILIFDGYSQKACKDFLVCNVLEETEIGRLMEKISLQSAFYSDKCEAQRSGFKCCTNSEPIEQIEADKLYHDLFLYSFHGIKKLTYKCFHDVIQSNKDVSFKTVTIPFSKFLFVKILNLVPFNANNYMHSEIYMLLRYMLPLKYRTGWLVGVVCAYFNSNQNLINQLKSHNEDPIGYELTFEMAFLSNVLFGKSYTAECFRKAVNSYIVFSLVGMNNSGTCITVKHLNEHNYLIKQINLNEFFIGFLSDRIILSYSYLVHNDSVLDERFNTIASNHSLTVEVYDDETNSGIIIVNGEIFDNIKILMGSKFLIGRNIGKLILNINEPVARLYSLSFSCLSTLTTIRCEFDVIGFLYTIPEHIQIILEVFGEVISNEMLMMPSNVIRLEFYQCEFETNISLPSHLKSVELYASVIANDAIIVFNENIEEITVLINMAGQFDLSGTGGFNRIDGKLNIISPIEYKKQDEILSLRLYCVYVYGIVYIDPSIEIITLNSVTLRENSKIVFSKTNKTIKITNCAGVFDLRENLGVEFHLEENMKIDIAKYSDVIPNVCNITLCNVHFEHNIVLPEDCTSIVLSSVMVPENVLVILNSSCKTICISNSIIALDARNVGVIETISLEFSTLKSDSIRFINSERVNHLHLYKICRNPAMIKSLLTDFKEIHHLQFNNYYVSQETDLFITFLDDSHSLSLFDEVSNDFISFLKKTCASQPCSSSSYLYMRSNVVINYILNAFLNESTAKTMKKLEIKDVFVSVDNCKLFPALCNLEILGVFRMESVMQLLHNLPPNLKILNIAGKFDRTVNQPIQYLIRPSVLVRLHNNMRVLVVDIEFVSNLLYISHLMPALEVLMVRYASLSNTVFRKQNKKIKLRELIVECTDNLIIIGQELLSKPKIYAFVSHLFDYVDFSLLDDFVFISPNKMMKIDPKSISLQHRTLNQQIMSLRQFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT48</accession>
    <name>L7JT48_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2590"/>
    <dbReference type="HOGENOM" id="CLU_1788172_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT48"/>
    <dbReference type="OMA" id="RRIEHTK"/>
    <dbReference type="OrthoDB" id="10369557at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="145" mass="16937" checksum="27105C813ECF7582" modified="2013-03-06" version="1">MCPRNMPAPVQAQPADLKFDQNNEFKREEYFKSQAKRLLAQQTYKLPPDGHTGPLLKSKNEIMRLENLKKAGEAALMRVKEKGRKFSEVKTDTKDTKEHAKTGREKRKGMGDAIRKVEQPKKNNNKSNNRKRRDDKNTNRKRMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT71</accession>
    <name>L7JT71_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome biogenesis protein-Nop56p/Sik1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3153"/>
    <dbReference type="HOGENOM" id="CLU_452833_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT71"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="2">
        <location>
            <begin position="241"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="603" mass="68736" checksum="3097FFC4D6AEBEF0" modified="2013-03-06" version="1">MYALMESADAINLFKNDRLVASYKFESAEHAQRIYGQVLKGVLPDEVENFLLDNDVDDLVVDKSLVKCGQKGACKSIKFVENQNKLRRLRETMKIREESVRGLSHSMAHKNVNFYTLDPLIAQSYCMLKQIESDIERYDKRAAEIYFNYLPELKIRKRRDESDDEKVEYKQLYDVEVIKKLWKIKENEDIDSKYLWTRDSVGVALSPNDWANLQKLIDLVELKRENMEKLLKYLEQQVEIHAPNLNALIGFRLAAELITLCGSLINLAKCSSSTVQVLGAEKALFRSLKSKTPTPKYGILKNNEITKSPRLIRSLASKIVLCARIDVFRRTKTDAYGKALRAVLETKIKTNKKVLTDEVLAKVTERLKETEKENVDKEGEEEEQAGTMNKRSKSGIDDQGTTKKTKKGRLSQSAEQKKKSVESTRDEKELPAGSPDRKTHSRKKHSKRDDEDGPLDKKTKERTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT75</accession>
    <name>L7JT75_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2843"/>
    <dbReference type="HOGENOM" id="CLU_417484_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT75"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="657" mass="76048" checksum="70D05537A82692FF" modified="2013-03-06" version="1">MDYMLYSQITSLDTQIRWILTFMTKNEKPDFLICDSLDDVNLDDIFSIISESTREELTHFRIENYDCWVDPLCIFKFNSGTHACARNLKDSQERCEYLRTLYVPVKKSLFMKVIDSDANEQVKLSDEEIREISENVLMFLKDKSVVLRAIAQKHSNYIELRNYVGSLFPEIFLSKKEQSITNPNFYNVMYEMRRYICLSIKNNTGNEMLLALDENNDKRPSMHADLCNIEDLIPLGFVSMSDDSLFANNDLLCEMFSDEKYSNDLTVRININLNNCDSEKVPGRLKEIISSSFMKLKIIHKITVHFENGRCDFEIESIPGLEQRISFENTVLYDKCCLPADLKRLSIVNSRIESFLVFPESLNELFLENVTALKYQNLQIHAKCNVNIKNMVGQVYVPHFSEYFLLESRTKAWSGELLNGEDGVINKLLLDNVEIRSLRIKKLGDNRWIDELILKNIIVGREIFLPVYKKVSNLTIIDSTGSFDLYDVANICRPLSLELISGKIEVNRKNENRLIEIKIINAKLLDNAAIIDSVSKLEMTNVTTQSYAKLKLHKNIFHIAFENCSATIMFNGLCNFDEIKFKEAKESNQTDQGLVPAFYFDKEADSTTSRLVMNNIHFNETINLSPDINELRLRQVYVNRDHTFTVNGQPNIVVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTB6</accession>
    <name>L7JTB6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uracil-DNA glycosylase</fullName>
            <ecNumber evidence="6">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="6"/>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTB6"/>
    <dbReference type="FunCoup" id="L7JTB6">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2787"/>
    <dbReference type="HOGENOM" id="CLU_032162_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTB6"/>
    <dbReference type="OMA" id="KMIGQKT"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="7">
        <location>
            <begin position="135"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="302" mass="34555" checksum="C6EADFD19957C9B7" modified="2013-03-06" version="1" fragment="single">VSLIAFSVVVIPPTLLFLNKNTAARNRALMKRNLTLYNFKRKKVQQESVTVKKDACENSTPITNSKIQKCSLLNSENKNENGMCKLCNLHLFLSEKWLPYFKDEFHKEYFGKIMTMLHDESVFYPPVQKIFYFSHFFPITDTKVVIIGQDPYHNKGRATGLAFSVPPNVPMPPSLRNIMAEVRRNYKDATCNLEDWAKQGVLLLNDTLTVSEAKPGSHSTYGWSIFTDRILKFVNEKCKNVVFMLWGSFAGKKSALIDGKKHLVLTSMHPSPFSADRGFNGCNHFVKANEYLRKNGKEEISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTC0</accession>
    <name>L7JTC0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small Conductance Mechanosensitive Ion Channel (MscS) Family [1.A.26], putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTC0"/>
    <dbReference type="STRING" id="72359.L7JTC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2792"/>
    <dbReference type="HOGENOM" id="CLU_1405646_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTC0"/>
    <dbReference type="OMA" id="RTTWNYS"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="6">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="194" mass="23203" checksum="C168A5193459601E" modified="2013-03-06" version="1" fragment="single">VDYKFYLTSVGPFLFAFSWIFQDSIKDLYKCFVFHLISHPYDVGDRVIIDDQENVVVRIDLLYTTFTNNNNRLAYIPNTSLFGKKIDNVRRSRNQYEQLTVFVDQNVRYKALDDLKYKLEELCKEKETVFTGHAYIREVSKTDDKLQLVLALEHNSNFQDINEKYRRRKESIDVVERALNETGIRYDEYYQFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTD8</accession>
    <name>L7JTD8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Component of the U4/U6.U5 snRNP/mitosis protein DIM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2364"/>
    <dbReference type="HOGENOM" id="CLU_2039700_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTD8"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="14181" checksum="621A4E3AE80745A8" modified="2013-03-06" version="1">MSIIVKTKADLNTQILQNENHIKVVSHGRKYFAHYSSLFNELEYRVSKLAKFVIYEESELDGLQFYYDNCLIKVDCGIGNTEIIDYELTRDQFVEIIKVVYMAAVNGRKVVFMNELRNINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTE4</accession>
    <name>L7JTE4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2514"/>
    <dbReference type="HOGENOM" id="CLU_3002301_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTE4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6718" checksum="BC54F8F3AC9FB71A" modified="2013-03-06" version="1" fragment="single">VIVDLKCMDDHTDYLVINHVLKEKKVLKTYKNTNLTDIFYLCVYTTYEVAILAKNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTN1</accession>
    <name>L7JTN1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2298"/>
    <dbReference type="HOGENOM" id="CLU_1200606_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTN1"/>
    <dbReference type="OMA" id="ASYSCKE"/>
    <dbReference type="OrthoDB" id="10513416at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="232" mass="27346" checksum="36E8F41CAF8B2C12" modified="2013-03-06" version="1">MVSFYRFFNFLYSVVFRHRGCSEIYTRTDSSEIGDSIRQLNEHLNLFKDMQEAILETEYHLIMDSGADLSNVSYSTLLYMLLYRIAEVGPFLKIIKMINEKYSFISSFNELFERCKVKYTPYRRILVASYSNKEFFKEFLIGLFSLFGVKSETIGELNGVMTKFYCLLFEHLEGTEFSLQFKDRFKTCIEELDKVHTDVFAQCSLSSLFDSFDNEEWENTFHVLLTDDSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTV6</accession>
    <name>L7JTV6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2215"/>
    <dbReference type="HOGENOM" id="CLU_1714608_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTV6"/>
    <dbReference type="OMA" id="KPEHIML"/>
    <dbReference type="OrthoDB" id="10361797at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="153" mass="17559" checksum="335DAB6B8AC3265D" modified="2013-03-06" version="1">MFLFIDVLRCYKYLYPLAKKFNEYVAMDTDGSLSLFSFKDLAPSYNPNAPYEYFPDQHSLLIGRSIVGDGTFRSPVYKGNGDWEVIYVKPEHIMLKNGTWCLSVRNELLMVKERALILSGCTGDSSQVFYVHDDRYLPRPSHRKIAQVLGAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTY7</accession>
    <name>L7JTY7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2875"/>
    <dbReference type="HOGENOM" id="CLU_2892293_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTY7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="63" mass="7379" checksum="A5FDBFCC49E6F766" modified="2013-03-06" version="1" fragment="single">VLSAPEERVWWVKNCEMLIKPTFNEKNVIFITPRTTDETSQVSRTKIAAENKLLGMARHRHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU65</accession>
    <name>L7JU65_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA replication helicase</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU65"/>
    <dbReference type="STRING" id="72359.L7JU65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2066"/>
    <dbReference type="HOGENOM" id="CLU_416891_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU65"/>
    <dbReference type="OMA" id="KYQGCES"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="279"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="363"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="459"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="658" mass="75961" checksum="B87798C040A4C391" modified="2013-03-06" version="1">MNVIDDISVSDDDLIECIDTQNDECTDTASFLKEQGFFILSDFYTNILRLCKCRFNTPCKITESILKMKGHKGIFLRKLMENIMMEEIYERKQSNKRLGCIFINQTENILEIVPVKQTDECNAFDASDNAFVNIYDEKVLVTTAEIISRTDSLKLRLNHYYNFKLKNIYIEEKSNNLMLKSMWYSLLFIATKSHLLHDAAVSSFEERKNTVGAYKGTELGAIDLSVKPPSSSDDNTAVSRHINRITNIHGAISSSQDQSLSVGSSMNIPHMYMDEFLSLNDGQKIALEKCLTTKEFCSIHGMPGTGKSKVIALLIKILLFHGRSVLLVCYTNLSIFNVLKRLNYSYYRAGSFKQERINSKSREDNVFTDKKVHKSVKEWKEYFEQSFVVSTCYNFKDPVFKERTFDYLIIDEASQQHLLLSLIPISISRKFVLVGDPLQLYPLAKSFRGISLLEFLGITCVLNKQYRMKRSIMQISNEMFYEGRMETDLEGDGEVELIDITDHNCKEIAMKNCMKDRTYVNQENRFTDGFFADFLKKLNGSCGKSMLLKNIEKIAQIIHERYDENTTILCYFNVTVEIVRRIDNRYKVSTIDKYQGCESDNVILLIYPFVNNAIMNSRERLNVALTRSRNRLIIICEENEMKNVELFAALLLTINKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU66</accession>
    <name>L7JU66_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-type ATPase (P-ATPase) Superfamily</fullName>
            <ecNumber evidence="3">3.6.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.3.8" evidence="3"/>
    <dbReference type="EMBL" id="JH994054">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2788"/>
    <dbReference type="HOGENOM" id="CLU_2225036_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU66"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
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    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="106" mass="12175" checksum="87BAF756D7F76DA1" modified="2013-03-06" version="1">MVVATQINARSLSSRVSPFLNIKRNNYFIGVNVAVLVCQLFVMQKFNLVFRTQALTINEWTVSIILAALLLVYMAVIRRLENYWEDQRIARWNSSLAHSRASTTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU84</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994049">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3279808_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU84"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4854" checksum="1A939521CC3A2A69" modified="2013-03-06" version="1">MMLEPSELKCVRGHLNVRMENRYRGVQFFNRQAFVLIEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUD8</accession>
    <name>L7JUD8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ75093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1967"/>
    <dbReference type="HOGENOM" id="CLU_1856706_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUD8"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="138" mass="14828" checksum="C5E6DA5947224EE7" modified="2013-03-06" version="1">MLAMNKNNNANINVQAVVFNSVVTEAERHAGSQSQATMLAGVDNVAVEVAVIDTVSENIQIGVEKVDMINTNIQNAVFYLNSVSDAEQTNVLPTLTNEVMPNSEPVFATHVVTVEQQSFADVSAPVSDHCQGDVNERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUG2</accession>
    <name>L7JUG2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="L7JUG2"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8826" checksum="1B0109A0430CCB73" modified="2013-03-06" version="1" fragment="single">VNLRIKGFLVDLAIFLRSASDVMVGNSCISWDVSLDICWGVGMEWLFYERWVENDSVEREGIDDPVLLQEMDYRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUH4</accession>
    <name>L7JUH4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2003</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="OMA" id="HRFNYNN"/>
    <dbReference type="OrthoDB" id="10389619at2759"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="582" mass="67374" checksum="CCCBF96A1E4F5800" modified="2013-03-06" version="1">MENKQTMKVIREILASSRNLIDPRLKSLVQLNITIDFMNLYHKYPQETEKIVTDYTNQIKVYDYHIKRLILKHRFNYNNPCMGYNACNTRSCLSKQPDSAIQTDQVIEGKERYCLNSLLKINHKFSNANNSIKKLNMRDCFRLAGTNELYFVEGRFFLLRENTKPLFKSFRCTNHLCRSPDTVLEIGNFLYYYSTETDSIELIFDSKHSKECRACLTLLQESFKERQIEKSYDFRLSEGAFALKCVTVCNTNYVNDECIGALGNFTRGLDGNLIFCVLKMWQIYKETRSIKSYSIESTSKFIFNHIKNNIDAQDLLMAIILSTQLFCDSKVLIYTTDVIDTSRIVSHFFAIHRKNTRLLYTNIICASGIYINDLSMYKNKIDERAHFVFIFRRNDGLCLRYEYERKTIDSTINDEGIAINQNIAPLNGGASTTSCDEHCPDGILLKHLDTKLFTELQIIALRIYTKNKQKISTSRIIYTLNHLIIGYRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUJ5</accession>
    <name>L7JUJ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2373</name>
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    <organism evidence="1 2">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2373"/>
    <dbReference type="HOGENOM" id="CLU_144341_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUJ5"/>
    <dbReference type="OMA" id="DITAIMC"/>
    <dbReference type="OrthoDB" id="10421118at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="128" mass="14487" checksum="3BCB526C42DCC125" modified="2013-03-06" version="1">MEKKIIVKSHVSFIKDNKKIYTLDTSLIDPHTNAPYSSLLSDGSTLALGTTKSGKMVVLPSNYMEERTLKDEIDYKYSTNSSDHDITAIMCFGMVNGNMVFIDDEYEDAIEVSIKNTDENEHKTHFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUL2</accession>
    <name>L7JUL2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein with PUA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUL2"/>
    <dbReference type="FunCoup" id="L7JUL2">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1948"/>
    <dbReference type="HOGENOM" id="CLU_090468_1_0_1"/>
    <dbReference type="InParanoid" id="L7JUL2"/>
    <dbReference type="OMA" id="NDRWIFT"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07953">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="80"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="170" mass="19490" checksum="B6D8906ADEE274BC" modified="2013-03-06" version="1">MSIFKNLKISTSNQTGGTQKKKIEKEIGQALPQDTYLHKCKNKIKLLSHNNSYIMFCYNDRWIFTLEYLRGCEQKELAYPSVWVDEGARQPLLRGSDIFVPGVYKYKEMIDREFVKNDVVVINIVGYGIFGLAVALIGYKEMSADSKGNGFKVLTVENDELDSKKLKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUQ7</accession>
    <name>L7JUQ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUQ7"/>
    <dbReference type="FunCoup" id="L7JUQ7">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2295"/>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="InParanoid" id="L7JUQ7"/>
    <dbReference type="OMA" id="AHCKKGQ"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="15928" checksum="2302CA7FDDBD8E9D" modified="2013-03-06" version="1">MQEVKTIGSKKHAKAHATTVPIQSPFSLTVNHVAHALIQDAFMRNKINELILTIGKENLENLCVNVSVRGGGHVSQVYAVRQAIAKGVVAFYGKFIDEEKKQEIQNRLMKFDKFTLVADPRRSEPKKYGGPSARAKYTKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUR8</accession>
    <name>L7JUR8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUR8"/>
    <dbReference type="FunCoup" id="L7JUR8">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1826"/>
    <dbReference type="HOGENOM" id="CLU_011781_2_4_1"/>
    <dbReference type="InParanoid" id="L7JUR8"/>
    <dbReference type="OMA" id="AMAKFPP"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="465"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="5">
        <location>
            <begin position="638"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="697" mass="79798" checksum="B40ECDE04DEAC547" modified="2013-03-06" version="1">MNLLNALLTQLTLNNLDAYILNHTDEHLSEFISDADMRVKRLTGFTGSNGTVVVTKTECALYTDSRYYLQAQKELIEPFKMMKIGVDKSLLEFLKDTIKEGRVGVSLRLISHERYKEMTKEFESTKLVLVPVENELVDIIWKDRPRRSASDIIDLEKYALDEYLTFLKNDKVRKIFDDLFKDNYKYEYDEMIEPDLIPGLTYSNKIGIVQKSLQENEAMILSSLDSIAWLLNLRGRDIANNTVFYAYVYITKDRLVIFTDVKVPRDIELRKYSEFYMFLKRIEENTVYVSDNVNASIADILGEDRMKKNNLVAKLKSVKNRNEIMGFFQAAILDGVALVKLFTWLNKNGDRVTEIGISDRLLEIKSQLVLGRDEDMVNNNKEDNASLATDRIGDTMHTNPLLVDMGSKELTNLVFELFTGKLTEQNKSLLQNMARINKNMFSSSPVKSPKAAKNNASNKNGGWNIAKTGFLFPSFSTIIGYGKHGAIVHHSASDTTVDDKNLILIDCGSQFIFATTDISRTIHLGTPSSEQIHDFTNVLKGQLLSKRLVGPKKNVGGLIQDLPRYYLWPEGKNYEHGTSHGVGTALYVHESPPEIRFGATIEAHQIFTIEPGYYKEDNYGVRIEDAVISLYNDNIFLQNMTFVPLQLNLLDDSLLTDEEVEYLNKYNENVRNILGEYLYDEKEKEWLINNTRFFNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUW2</accession>
    <name>L7JUW2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Signal peptidase I</fullName>
            <ecNumber evidence="1">3.4.21.89</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.21.89" evidence="1"/>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2230"/>
    <dbReference type="HOGENOM" id="CLU_1020133_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUW2"/>
    <dbReference type="OMA" id="GERNCEY"/>
    <dbReference type="OrthoDB" id="10504003at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="304" mass="35246" checksum="9FB6240D523DD1B5" modified="2013-03-06" version="1">MFMIAIFLIRKDLNKKKVSRLMLQPRIVKMKIGERNCEYGYEKRQGVIRSEIRGKECENEYETKRGMIRSNTEDREPKYEYKRSFVRESRDMSARNGNGGINDVHVILGDKGQNGENDRVRMFIKGKETQCPSSRMRIVMNGTKTRNNENGREFTISGNREGSIEQNRRATIMRRNERNEAFNNDALKHANSEKTPMNGYSKPYQGKLEFVVPSRKGFTFTNVKFNEMESKIHNGIPSDKFVGKDLCITRDNCHSPNETLVRINNAHCSRDRAYRNASEGCIKRSGIIQEAAQALLILKYRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUX8</accession>
    <name>L7JUX8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Box H/ACA snoRNP component, involved in ribosomal RNA pseudouridinylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUX8"/>
    <dbReference type="STRING" id="72359.L7JUX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2206"/>
    <dbReference type="HOGENOM" id="CLU_084513_3_0_1"/>
    <dbReference type="InParanoid" id="L7JUX8"/>
    <dbReference type="OMA" id="HEATAHI"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="1">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="13593" checksum="F81AD25013DE11D1" modified="2013-03-06" version="1">MIKFATPVLPDDAVAHVIKIIDHLKTIKKVIRGRKACHKAIKSKKKGILILPFNISPCDLIAHLPMLCEDNEVKYCYVDREVLRRASNVDTLTCCVFVKKNAAYRGDYNVVKGAIIHDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV30</accession>
    <name>L7JV30_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative XPG/RAD2 endonuclease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV30"/>
    <dbReference type="STRING" id="72359.L7JV30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2147"/>
    <dbReference type="HOGENOM" id="CLU_550046_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV30"/>
    <dbReference type="OMA" id="KDTDRIC"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="1">
        <location>
            <begin position="170"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="526" mass="60988" checksum="2C590C132F4D0A29" modified="2013-03-06" version="1">MPSPRTTILSFCVFVPDEIFIFKKIIFHPLMPIRGLDQLKDIAHIATKRPCAVLQNTSIAVDGFWFLRKYLMPISVTHVLIHGLGKFYAGILDIFKKFVAENKIDVIWVWNGFEFSKSQAPLVHDPLRMGMDELRKGNFSLADKHLRKVIDLEAFVDEINYFLRKDTDRICCIRAPYSALGQCAYFLRNNVVDYVFGATDFLLYGNGEKVITEFNFLCKDREDRIEIFCRKDILKTLKLPFSKFQMYALFLGCEYCATMPPYSVNFEVFEILEVLRIGNYSYSGIKAYLYTFYGTDPMKSGYKPNILIDNYLNSFVCALALLDYHPIMSTEGRIELLKDTNVPRDLEDVLGAKKAAYFYEQLFLCNIKPDYKNHVGHRLTYLDKDGHFCYTNVEGISELHQFLLLELSQKNFFTEDILIKLLFFLDCTAVPADDVHIKHFLQKNPNMISYYCEITNLYACYVNKAKTTFPFSLTMIGMISVLSMDRVKEPAVVNYLTNVCQLFVMNESRDRNSIVVIKFLKKFLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV35</accession>
    <name>L7JV35_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative starch-binding protein</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV35"/>
    <dbReference type="STRING" id="72359.L7JV35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2152"/>
    <dbReference type="HOGENOM" id="CLU_013007_1_1_1"/>
    <dbReference type="InParanoid" id="L7JV35"/>
    <dbReference type="OMA" id="HRNVPGT"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="9"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="288" mass="33091" checksum="024E732E8E702E70" modified="2013-03-06" version="1">MIATERENALVIGHRGCGSNRATNIYNCFENTIESFMKAHSSGADAIEFDVHLTKDYVPVIFHNFCVPVNGKNAFIQNLTYAEFLNAGKEFVSQERPHLDVNDHRNVPGTLEDVFKHLNDGLVFNLELKYPTKDEMDEFNISETIPRETFIQHIMKVVYRYKNRRIFFSSFDISILISLKQYDTSAHIFFLKDFEYSGSLKDFVPLFSQELRICVLSGIDGIVFGSSTLNGDLALLFNFIRSLNLKIILYGERLKDRNFVKQVNDLHIVYGFIVDDVPSATEVLKNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVH4</accession>
    <name>L7JVH4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Zinc finger, SWIM-type, Zinc finger, PMZ-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1623"/>
    <dbReference type="HOGENOM" id="CLU_043427_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVH4"/>
    <dbReference type="OMA" id="FDCINAI"/>
    <dbReference type="OrthoDB" id="2187956at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="532" mass="61164" checksum="22A3A3872CD34434" modified="2013-03-06" version="1">MKVNDKFPTKKEAVTAIKEFLDSKNFTYDQIQFTPKLITFNCIGKKEFNCDAVVHSLYKKKEDAFVIKKIKLNHKCPPDLKNMGSVEFIRNEIRKCGEDLRIGEMVQAMNKKNMKIGYNSVWRALHEGEDEDGAQAAFVKEFVMLNPECRALSGPDHIFVFFPVLEYARKIVEIKIVKRKESGYVLYALIYDPHDCVQTLAFMVTDERSVAASKDMFMANLGKYMDVGSAVFLCEIRDAYLFEHETFFIKVRSICREVYRKCKDRNVVIKVWNFCNSNEELREIDVLREVIDEFNSKEHVEDEDRKARQSDEKGSTEDDRNKENENAANKSRASKAKSKKKGGAAGVIKLENYQKGDRILYGLQNLSEPDLDLLYYNLSGDLMDISNAITKLISEHNAARRKKDAAFGENIRNKIERKIEEKCAVDECANDTYNVTLGKETCNVSLNDMFCTCGIFQEYACPCTHALVLIRHLGLDPYNFVSTVFLFKKEMYGEVVPVVNENLKQQNVQVLLRRGPGRPKKGNVRRYDEAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVN6</accession>
    <name>L7JVN6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin fusion-degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVN6"/>
    <dbReference type="FunCoup" id="L7JVN6">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1662"/>
    <dbReference type="HOGENOM" id="CLU_102810_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVN6"/>
    <dbReference type="OMA" id="LPKANWV"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="3">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="4">
        <location>
            <begin position="110"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="225" mass="26365" checksum="69A4E0A5BF5DAFAA" modified="2013-03-06" version="1">MIFNFFRQNDYDLSLKWRLIPTKYPPNSPNNFGGKALLPQRVIEDLVNLQIPAPYTFEISHSNRLYVSHTGVLEFTARGEEIVVPEWLYQQLEMDQCGLVTVTYKQLMPGRSIKLLPHTTDFLEIESPKRELEKCLVNYQVLTCGDEIVCSFDEYGAMRFTVNQIEPDDDAIYIVDTDLIVEFLPPIGYEEKLENEKSVMRFVEFEDVENDDVKCVRMKERRNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVN8</accession>
    <name>L7JVN8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1534"/>
    <dbReference type="HOGENOM" id="CLU_2967567_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVN8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="6776" checksum="EC61047B5E62D8F4" modified="2013-03-06" version="1" fragment="single">VHCILKTFQSFRCERFYVYNDLIMSVIDDVFLVLTVIDQTSSRTTAASRKIPFSISLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVQ9</accession>
    <name>L7JVQ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2226"/>
    <dbReference type="HOGENOM" id="CLU_3144013_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVQ9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5922" checksum="626C36F9225304B2" modified="2013-03-06" version="1">MEGYLMVKQFLLAQRNCLPLSFLKDFGSDYMFAYVLFLYFRHRLIFSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVY8</accession>
    <name>L7JVY8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1414"/>
    <dbReference type="HOGENOM" id="CLU_2414861_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVY8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="92" mass="10904" checksum="BC66EA8E2100A6A7" modified="2013-03-06" version="1">MATLKACVYRKIDIPISKSLYMKISEMMKKDNHNVWLTDSEIAEFTQHLSLFMDEKVPILYQIDYQTRCDEKLMDRIKKFCFTQHAAGIKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVZ6</accession>
    <name>L7JVZ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperones HSP70/HSC70, HSP70 superfamily</fullName>
            <ecNumber evidence="5">3.6.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.3" evidence="5"/>
    <dbReference type="EMBL" id="JH993983">
        <property type="protein sequence ID" value="ELQ75191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVZ6"/>
    <dbReference type="FunCoup" id="L7JVZ6">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1868"/>
    <dbReference type="HOGENOM" id="CLU_005965_0_1_1"/>
    <dbReference type="InParanoid" id="L7JVZ6"/>
    <dbReference type="OMA" id="DSKPCIE"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24028">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="551" mass="60118" checksum="4AB30C4543AE9D31" modified="2013-03-06" version="1">MSSQGTKQETSKAIGIDLGTTYSCVCAYRNGELEVISNEEGARITPSIVAFDEEGNIVIGTAAEHRLTSNPDKVVYDVKRLIGRGYDSPILESSIKKWPFRVVRWDNERNCPTDRPARPDAVDNIRIEIVKGGKTTYYDPMEISGYVLGFLKRAAEAVLNSGVTTAVITVPAHFNDNQKEKTKMAAEIAGFKNVRLLNEPTAAALSYAYDKMRRKEANKEETVLVFDLGGGTFDVSILKFEPPSESGAIAEVLNTEGDTFLGGVDFDNALFEHCLALFLKQNPSVKKEDIKDRAKRRLRMACEKAKRNLSAMYSTTIEIECLHSDLGLCTNITRALFNNLCMKHFRRCMDRVKGCLLGLAKIKPDYTSEGFLTAASAANTSAINDAIAQIDRVIVVGGSSRIIKIREMLAEIFGEHKLDFSVHPDEAIARGAAYQAALISGGTSLDVECPLLLLDTVPLNISIETLGGVATTIIKKNTVIPTAKTEVFSTASDNQTSVTINIFEGLGEMVEHNNLIGSFNLCGITPARRGVPQIEVTCDVDNNGILVVTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW50</accession>
    <name>L7JW50_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1350"/>
    <dbReference type="HOGENOM" id="CLU_478331_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW50"/>
    <dbReference type="OMA" id="YNIESEC"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="573" mass="67042" checksum="71D224494E24BDC6" modified="2013-03-06" version="1">MIIFVFYTLILAADDITHMFERLNVLRPKNRRVVPNYNEAFQMLTPEERSERASDNKSSTSEFVKKLRTKANNTLKIVLLKRKHMALRMINRYLIGKESSSKNIINPPERPLLSSFNNTSSSTWSESTGAIPKQKHLPREMPNTANQPKHPKEQTREDDSNKSSSNESLVFYTFFNSRDTQSNNSSKMTMCDVSDRHRDHQQHRRTKCSSNPEIYNIESECYKKYVHETFAKLPSVTHSVEKVEVHAEDVERSDHTRVKTFQVTENKSLHETDQYEGAGASGYTESLESYHTTERDTRLICDVQEKVSDVELSNLLGIIQSDRLNFRFNSSNGHIYDFKIDNMIQLSWDPFDATIKDLLGDFLSFAENYPWCVQEIGDKHVHDQYEILLSCCKDVIYIHHVFLDKNLLFEEHCEILKEKLLEFRKSEQISENVEVVDPAIHDINRKTQLISDTTICFDAIFNEILEIEEMFRKYTKKVFWKNGTNFILPLYNCIMPLVKESIQRYQKSQILLRCNEDEITAIKTPIQSVLQQLKIVTTSYLRFYELYGTFIARMHENISILYHMSYLDSSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW74</accession>
    <name>L7JW74_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1438"/>
    <dbReference type="HOGENOM" id="CLU_513086_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW74"/>
    <dbReference type="OMA" id="CEYDRTI"/>
    <dbReference type="OrthoDB" id="10647450at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012474937" evidence="1">
        <location>
            <begin position="16"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="551" mass="64226" checksum="0C33CB33C40285EA" modified="2013-03-06" version="1">MLQTISMMVLEFVFAICSQFSDEDMYDSNLLEVQMDDYNPRHMTIDSLEKIKQETCGFFKIPKAPCYNSKDSGRKQENLTDDATNTHSALHDNEHLISTANTTKPSAVSNMDWKEHASEDKQVKCKCKRCLLDKINSLKIKSNEAAPCENINSSTESKSLLKKSGEKKARYSLASNIYTQTLPANPDKKLGKRIMVKEIKYSVQETTPPILPSSSTGSIDDKGRKTTNVKRLLPLSFNNNVKRSLDACKAKIYIKNKTYTSVARSTYEIENIQPINYEIVYEMCKKKIDKLVFAISNFQYHKFDHSTIIYTYFRKSNRWHWYFNGQQLINWLTILKIELFKLFTGSLLEENLCDSSTIWQFNNIIDTLEIDINMILEANRRLNETYKAFAKYLIDFKRISKGLLERKNNDFIRRYSRYMVSPSELFTLNNEFLFLIKTCRKKLDVLLVHRFSKTSHSFMYHNMSYFLDALSDWCLITGRLEQFTVTVHIYRAISTLFNKLLQSLEAFLFTYDGLIQCNHRLSLTLCQFTSLISNVQKKIVNHPDDTFSRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWC2</accession>
    <name>L7JWC2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWC2"/>
    <dbReference type="STRING" id="72359.L7JWC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1376"/>
    <dbReference type="HOGENOM" id="CLU_128308_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWC2"/>
    <dbReference type="OMA" id="QNKRQIC"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="146" mass="16736" checksum="E71097051D1D2AAC" modified="2013-03-06" version="1">MQISKTEVDAALGLLKINSLRRRKSYYGMKVKKTLLQQSVLKAVYNITNFPSTETRNELALLLGISQRSVQVWFQNKRQICKKKDTSKNSSDRAFVNEYNKFVQKEINADGNEEEVFDVPSTKLVEIINSCGLQIKNKSDEDEKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWS5</accession>
    <name>L7JWS5_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1559"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWS5"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="ELQ75516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="817" mass="93460" checksum="FF5282B281919015" modified="2013-03-06" version="1">MKVIRIVKNCSVELSISDMCIILEHWLSFKENAGAFAHVICFNLQCNQESVDILDELKACIAYPKHEAHDKQIKKFSNLIFRTYVDCSSFIEVVRSQGTFFLKDGKDEIATCCEDSHYKGGFSMCMRLTDLNIGFLFANLYLEYNYFIRNKEVLFEKFGDETGKFALTVRILDIHNKPERDYRLSQMCLDEKLRVIMHSRLINSQGIKNIMLSFRDVKTPPTSSTLLQIKKLSTIRLDSCSTRFLHSLPIISNTNVEIVHNKKSVSSCQMIPRKLTKIFYIGCIFTDDIRFPSHLKYINIKNSKISDGNTLFFHEKHEEMIIFNTYGMLVMLGTVGFGEIFLSSPAQSSLKLIRNPISRKLSLSIEYATIFDDVNITEEIEKLELANVKIQKCTVMSFSSEIKQVILRDCIGLIDLRSYLGGYFVFIRSTTMSVFSLDDTGYSSLVLRTVFSCVTLELTGDYHSVTLDNIIMENNSRFIINASCKKLTINTCDAIIDVSKVVRFDMIHMIFTPGLCSHVQFVGISMVTSLKITNFFENICSVITVLSSLTELENLRFTNSSAKEIQKSQTNFPTSIFPLEYEDDGNERLLTNRSDIKNSVDPKTEVSIYGVLKAISCSRCSNKLKKLEFNSFAINLSYLYLLESLPNLQILNICVQNMTKHFFQYLPQSLLLLDIRGIYNHAEAPEPENMEDDQVSNSPIHILKILVIDTNLLSCLCRIAPIFPHLKVVKIHYVALPAFNLPAGYEKIKVSELIVEGENGLFDSKWERLEESELMPLIELLSQCFDMQHVEYFLVILGHELVNINPRTFYVIDDVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWT5</accession>
    <name>L7JWT5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993900">
        <property type="protein sequence ID" value="ELQ75943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1093"/>
    <dbReference type="HOGENOM" id="CLU_2160177_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWT5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="111" mass="13297" checksum="02D637DDDD5D01B7" modified="2013-03-06" version="1">MCWFSSQLKRDSVVTYNNEPSIQVFAQCFNLDIVRHAYQALNIINTELQNFTDIHRSLLEIEKFAKDNKFMDNERTLIGIKAMYERYNTFKIEIIDMLHLFINFHSNIRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWZ7</accession>
    <name>L7JWZ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993919">
        <property type="protein sequence ID" value="ELQ75825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1218"/>
    <dbReference type="HOGENOM" id="CLU_3244856_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWZ7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="43" mass="4893" checksum="A4114F92C17FA419" modified="2013-03-06" version="1" fragment="single">VAVVEQVVAVPQAGNLMNYCTVDTDTYTVYFHIVIYHIDPYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX21</accession>
    <name>L7JX21_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1464"/>
    <dbReference type="HOGENOM" id="CLU_1670622_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX21"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="158" mass="18691" checksum="110633585BE1D3EA" modified="2013-03-06" version="1">MRCNLMVNEQQENHSLRVSGDYKFIDTNLAVFNIIRQCMLFIEEELSKHKDDDEDEDTIITFSFFGSKKQSIKFYKTLRLNDLKSFLKKGMPKRSSLEDIGASRLTNMVATYFKCSVYDIFTYDDLKKIFTNLKNNFSFYPVLETKGNYFFLLYLPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX25</accession>
    <name>L7JX25_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">THOM_1048</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="JH993892">
        <property type="protein sequence ID" value="ELQ75984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JX25">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1048"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="L7JX25"/>
    <dbReference type="OMA" id="CYDRNDS"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="16">
        <location>
            <begin position="211"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="415"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="631"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="730"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="812"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="13">
        <location>
            <begin position="905"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="1292"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ELQ75984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1381" mass="156164" checksum="03C0DB2539C33076" modified="2013-03-06" version="1" fragment="single">VXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQQNAFYHPMPEITEEDCWTAISSHFDQYGLVRQQLDSFNEFIETTMQEIIDENNTLIVQSIPSAGKESVQKIILKFGQIYISKPPVITEQDGKTSTLFPCEARLRDLTYACPLYVDVTKSVVENEESDDHFYRQVPIGLVPVMLRSSCCILHGLSDKNLTELGECPYDQGGYFVINGSEKVLIAQERMATNVVHVFEKSLATYTHYAEIRSAPQKGSKTPSALIVKLVKKTETEFLLRATLPGVRQDIPVIVIYRALGFVSDKEIMEHLIYDPNDKEMLQVIRPSIEEAFVIQDQNVALDYIGKRSAPAGSPREKRIQFAKDILIREFLPHIGDKQFCETRKAFFFGYMIQRLLNCAMKRVSPDDRDHYGKKRMDLAGPLLAQLFKVLFRKLCQETIKHMQKCIENKRDFNIALGLKTSIITQGFRYSLATGNWGEQSRAMQTKAGVAQVLNRYNFISTLSHLRRVNSPMGREGKLAKPRQLHNTHWGMVCPAETPEGQACGLVKNLSLLAYISVNHPIEGIVELLEEFGLKSLEEVAPSEVYKATKVFVNGTWLGITTEREFLYTVLKRMKRQARIHKDVSIVQSLRDKEIRILCDVGRPCRPCFVVENNRILFTAEHANMLREGKMIWEDLVNNGIVEYLDVEEEDQAMICMSPEELYEQQMVTDRINAELRGESVERPRERVLKHTSKHVGSVYPGNDPHDLITNYTHCEIHPSMILGICASMIPFPDHNQSPRNTYQSAMSKQAMGVYATNFLLRMDSLSNILFYPQKPLVTTRAMEYLRFRELPAGQNAIVAIACYTGYNQEDSVIMNQSAIDRGLFRSFLYRTYTDQETMNGPGCVEVFAKPRRGEVLRMKNLNYDKLDEDGIVNPGVRVTGEDVLIGKILPVIERMDVNGNSLIDNRDEKINTESNTMNVSWKDASTAMRPTEEGVVDSVIVTNREGYKFTKVKIRSCRVPEMGDKFASRHGQKGTIGITLRAEDMPFTSEGIIPDIIINPHCIPSRMTIGHLIECLLGKVSALAGEEGDGTPFSDVTVGAISEQLKDFGYEHRGLETMYNGMTGRKLDAQIFIGPTYYQRLKHMVQDKVHARAHGPLQVLTRQPAEGRSRDGGLRFGEMERDCIISHGTSLFLRERLFEVSDFFSLVVCEQCGLFCLEDGCKGCGNKTKLAIVEMPYAFKLLLQELMGMNIAPRLRLCDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX63</accession>
    <name>L7JX63_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1713"/>
    <dbReference type="HOGENOM" id="CLU_1939593_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX63"/>
    <dbReference type="OrthoDB" id="10384120at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="130" mass="15483" checksum="352E513DF2ECE0E0" modified="2013-03-06" version="1">MEEVSSDNNAKRVKTSELPNISDENGLESFAECQNYVQPRRMHLNRRIHDYYKLPRGSEQIIVDQFFKRVKSGIQYLPDYKSDAFYLNLRKDFSSNILKLSASPDIMKRLECVELKRQQYFLLIFLRIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX72</accession>
    <name>L7JX72_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1723"/>
    <dbReference type="HOGENOM" id="CLU_3335900_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX72"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="38" mass="4489" checksum="01869A87BA6D4477" modified="2013-03-06" version="1">MHALGMLITLMGRFYNNLFVCIDFLATVIMNDIRRRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX80</accession>
    <name>L7JX80_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase, LTR Retrotransposon</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="JH993878">
        <property type="protein sequence ID" value="ELQ76078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX80"/>
    <dbReference type="STRING" id="72359.L7JX80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0954"/>
    <dbReference type="HOGENOM" id="CLU_000384_29_2_1"/>
    <dbReference type="InParanoid" id="L7JX80"/>
    <dbReference type="OMA" id="WTHISIN"/>
    <dbReference type="OrthoDB" id="2195316at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="113"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="245" mass="28913" checksum="A6F71CE2831D1F4D" modified="2013-03-06" version="1">MKYVKGKENSFADMISRNHKVTELETEDEIVGIKLYTLKAEEKYIDLNEEKKNMIISKAHPAVEHGGINSTYNILAKRYKWKNLKREVIDFIKVCEPCTKFRDSLRDIQRIRINLKELFETIGLDIIGSLTKSENGYKFIITATDWMTKWAEARALKRKTAKEVAKFFIEEIMLRHGTPRRIVTDQGREFMEETLKKIFELLTRRKITTTPYNSKCNCAVERFNGTLMNIFLKLSYPNIHQWDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX99</accession>
    <name>L7JX99_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1328"/>
    <dbReference type="HOGENOM" id="CLU_727991_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX99"/>
    <dbReference type="OMA" id="MIHNTIM"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979103" evidence="1">
        <location>
            <begin position="31"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="380" mass="43797" checksum="47E548E5C1B11C69" modified="2013-03-06" version="1">MIHNTIMQPVRHLPFKTLVLFALMTNMLNASTPVNILDEIYDVRRHLCTNAIVSGDDTDRLPFLYVAGLSLPPSTDAEVLVRMNTMRAAVANSYATQPLKSFWFGSENDMNEILKKVIDKVPSKEIAAENNFTKLAKKFLDEFHEVTSKIVKECGSYDVSHIKVFKIDPNNFDDAIAVIENGLNEEERTLDSFETAYTAFVKMFEHMETQPNDVRLVNLAKAFYMLLNETRAHIILIYQLYGILIESSSSKSKDSSKKATAERVGTFHEFLRKLKAQIDNDRLEKKHFITTAKMIVRTLNDFRMTCIFMDENSIMLANFLIYQQRKHLHHVLSEELLDYWKSSANKRKNDYEKMESKDKKEINMRMWPVGDESERAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXA7</accession>
    <name>L7JXA7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chromatin remodeling complex WSTF-ISWI, small subunit</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_1679</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXA7"/>
    <dbReference type="FunCoup" id="L7JXA7">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1679"/>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="InParanoid" id="L7JXA7"/>
    <dbReference type="OMA" id="PRMDEWQ"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="79"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="371"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="669"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ75382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="833" mass="98596" checksum="07150FE22D100DBA" modified="2013-03-06" version="1">MKKDQNNEPSGSDDEISPLINFFNTRKDNKGSLNRGKSKDRGILDSELDLGYAYSFRTSPKYIRGTLREYQIEGVNWLISMHEKNINCILADEMGLGKTLQTITFLGYLKSFLKNDTPHLLIVPKSLLHNWKAEFKKFLPSFRLFTFHASHVEIKEMEETMENTNYDVVITTYEMCISAKKVFQRIQWCYLVIDEAHRIKNEASLLSKIVRIFRCEHRLLLTGTPLQNNVHELWALLNFLDPKLFKDPEQFEKWITQMENDNKGGIDQLRKVLQLFFLRREKRDVEKTLLPKKVINLYPQLTAMQRNLYKMILEKDLTPLLHKREIKSSLLNVVIQLRKCCNHPYLFDGMEPGPPYTTDEHLVYNSGKMVYLDKLLTEMKRRNSRVLIFTQMTRMLDILEDYCTMREYEYRRIDGSTSAAERGEAIDDFNAENSDVFVFLLSTRAGGLGINLATADIVIMYDSDWNPQIDLQAQDRAHRIGQTKQVFVFKFITENTIEEKIIYRALKKLKLDEILVKNNLNTSSNINEKELIDILAEGVENIFDKEEKTAELNIEEIIKIGEEKTKILNTQLESVTLSETQDHNIEIYEWEGEDYKNKAKIEKYLLSNRRRNSSLFQRPKQLILPEYHFYPKELFEIIKKENELYDQGEQLSEQESKRKEELMEMGYRNWTKKDFLTFIKVTEMYGRDNFEEFKKHIDKSEEEIRGYHRVFWGRIDELDEKDKILAHIAKGEQRQKKETVINTILKRIFEDNEPLRLKNIVNVRSKNFTEQIDMAILRGYYYRKDAEYLQNLLMELKRKHLLNFFVRTLTLNDIQKRLKALKSALCKSCNKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXI5</accession>
    <name>L7JXI5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993867">
        <property type="protein sequence ID" value="ELQ76153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0869"/>
    <dbReference type="HOGENOM" id="CLU_1490011_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXI5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="20021" checksum="26B2EFE6157CE799" modified="2013-03-06" version="1">MFNEWVVITNVVGQGLCYLLKWIGKNSVRGGFVEMIASGDATDKQLLSGLGFNVELCAERGSDSAVSNDFELNVISLGNLSYSEEMFGGQCSCRMRKAGIGVGDTRRELSTRSNVICREIEKISESQKQLVSIEDVDEQAVDVVILRPGIICFKRFLARNCGFLFIGALFSVWMVLTNEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXI6</accession>
    <name>L7JXI6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Cullin like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993869">
        <property type="protein sequence ID" value="ELQ76144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0878"/>
    <dbReference type="HOGENOM" id="CLU_011834_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXI6"/>
    <dbReference type="OMA" id="HAFMRIK"/>
    <dbReference type="OrthoDB" id="10288212at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="598"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1007" mass="114406" checksum="720BADDC87970096" modified="2013-03-06" version="1">MDIPKNKHNLSVIKDQISRLARNSTISAVSLYNSIFGLNGCLDAVRDTVIGCVVEECLWWYECIVEGYEGYVDGCGCSESTGGCTGRDENDEEGGSTGRNENSIDRNDSIGGDNNGIGRNSIGRDNNNDNDDGNDIEGSINNNDNDEKTSSPSANDVDTTYDNEHACAMQLLPPGQYITTCSLPHHALADIIHRYAHYFDTFNAFITNLADLCFLLNTECWDVHEMGMATWHMHVLNRLVHFGHAVCAAVHLSPYSNDRIDTLVRVLHAFMRIKLDHSTYYTLTYERTLFMRINVLYARITLTHNYAHEVHRILTHEIESRSGYMLPVSFPAHNQALINHFILPYSSFIVMHCIRNINDYRVIYELNDERTNALFERGMAVYLRSVRIDALCINELFERMISFFGDRKGVQTVVERYRAVLMAMHDNVERVVRWIDGLVDGRTDQDVILDGTVSNDELGLVVEDVDERILAEGDDERNDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDCINNNNSNVNIDSIKNNSNVNINATCINNQNVLSTAKPFHPIIPQPLLNMLPYTNTDIFITQYEKKMMTRLLSHVVHVSREREVLEQLKPYFVPNLFRKCEHMLSDVVRSCGLMEDYERVNGYMMGGNACKRLYVGMYGDTEDNIMHEQNKVENKVEHRNANKVENKNENKVENKVVHEQNKNANNSINNPTSNNINNLTSYNFNSNNIINLTSNTITLKQPIHHRILTSHMWPLTPRCLKYPPLKELSSFKTFYNSTHSTHKLIYDYELSTMDVRIGTVILRINLVMFAVLRKGQGRVTDLINTMGDTECVWDNVNRMAEQGVIVLNGDVYVLSEWLSAQRDNNGDMRINRNNTCMNEQGCINANDNELSYRFVHAAGAYELTKDLTADLKCSKPRSKPFKQSTSNDSIVLSRICRLMKRRKEMSGAELGSIIGEGVEEGLKVAVEKGIVVCDDGRYVYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXL0</accession>
    <name>L7JXL0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Man1/Src1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXL0"/>
    <dbReference type="STRING" id="72359.L7JXL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0970"/>
    <dbReference type="HOGENOM" id="CLU_524802_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXL0"/>
    <dbReference type="OMA" id="KAYEWLG"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="55375" checksum="F7FC4D46365A3311" modified="2013-03-06" version="1">MVKRTKTPEPDEYLTKEYDYTKLTKDQLRKILSEQGVTVMENKLKTEILQMYKSAIYDKIDEIKQKMANIKADSKGIEVIESDATNFSAENPFQSPKKGDKDGENFVKRTPVRKIEMERNADSRTPTRIRNIYSSFDMPKDVSNRKPRRVSLVDGKSVKDEKDSNLLYRTAKESIKRHLDRQGLPSVRDRTPTKSPVRGVHKTMFSPSDVKQSINVQKRPGGHNFRLFYISVFPLLAIIIFYLKYFAPYCTNGGRCCVKLPKNTFLDEKGRLRCSKGYVLQRNILFPNKAVRDIALSDDPEEIVRYLRRINTEVYYGLRHSKLVELGLGENLRKKVLAYKDVRITDNFMFFSNKRLFSPSIIIRSIYIRHFYVLMFSILAVFVALYAINFYKQLRVKNNYDKVIDMLRLQKKNSSQFQVNPFLFEEQIVGHSGLKPQEFLDVKRLLEMNTSVTIFDISVSGKCAKAYEWLGTIDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXL2</accession>
    <name>L7JXL2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1537"/>
    <dbReference type="HOGENOM" id="CLU_2063122_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXL2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978859" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="119" mass="13465" checksum="818521BAA80D6EA9" modified="2013-03-06" version="1">MNDMGMYFIVNQLFILCSISCSEEYVGEYNQAAIKYFLEETEDFVVTNNEDSRIIEYLINELTGLLTSMRTILGECKNLDSILAGNDGKDGRNTGYKNLKSFFDIVCLEDVLGTKLTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXN5</accession>
    <name>L7JXN5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase alpha-primase complex, polymerase-associated subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993921">
        <property type="protein sequence ID" value="ELQ75816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXN5"/>
    <dbReference type="STRING" id="72359.L7JXN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1229"/>
    <dbReference type="HOGENOM" id="CLU_3175706_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXN5"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="47" mass="5431" checksum="22B07A15CA54A785" modified="2013-03-06" version="1">MLPNLVILNGPFIDLSNKEVEEGNFNFPKDQQPKNLDDVFRLLITPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXR5</accession>
    <name>L7JXR5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXR5"/>
    <dbReference type="FunCoup" id="L7JXR5">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0809"/>
    <dbReference type="HOGENOM" id="CLU_032087_3_2_1"/>
    <dbReference type="InParanoid" id="L7JXR5"/>
    <dbReference type="OMA" id="GPFKEDE"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="9">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="296"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="387" mass="43872" checksum="C62B75110200BDF7" modified="2013-03-06" version="1">MAGPSGLQLMQGGDVQEICNKNIDKHTNKEDYVYNTNISSIDSGTSVCTAESVLLYDIDKMFVKTSCFTTQGRGSYPEKRKMSEYLKYGVIYLDKPKNPSSHEVVTWIKNILKVEKTGHGGTLDPKVSGVLTVYLNRGTRLSKIEQNAGKEYVCIVQIDGKVSEEKFKDALRFFEGRLIQRPPLISAVKRNVRMRSVYKNEFLELKEVDGVSYGLFKVSCEAGTYIRVLCEHIGLYMGIKAEMLELRRTRSGSIREEQCFTMHDVLDSHYIFENKGDERYIRRVVHPIEYSLRNYKRIMVKDSCVDALCSGAKLSLNGVIRFDRNINVGEKVVVITTKGEAVVLAETLVSGAEMQINEYGLVAHTLRVIMEKGLYKSTWGTKKFNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXW0</accession>
    <name>L7JXW0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Heat shock protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0743"/>
    <dbReference type="HOGENOM" id="CLU_2238653_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXW0"/>
    <dbReference type="OMA" id="IERALCQ"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="105" mass="12799" checksum="2FCF8702A4E9BBF1" modified="2013-03-06" version="1">MSYLNLNRNYTYNDLDQAYKRAIKKYHPIRTKTSTHLYRITSEYNYKKNQLRYQECNMREMNVDEIERALCQCGHRYDLEMENDGIVECCWCSLKVKIVGRNRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXX2</accession>
    <name>L7JXX2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FYVE finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXX2"/>
    <dbReference type="STRING" id="72359.L7JXX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1465"/>
    <dbReference type="HOGENOM" id="CLU_309313_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXX2"/>
    <dbReference type="OMA" id="GTHEYEF"/>
    <dbReference type="OrthoDB" id="2192372at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="311"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="953" mass="110591" checksum="8005D018DDF088AE" modified="2013-03-06" version="1">MSKEMKDSFENIDNATLENNGRNADHKNNNEFNEINLCDEYSVILSEYKKYTQFPPIGYYNTKVRPLGANLFIINLLDFSSVILSVVETDTMQVYIQSVFGTHEYEFSKKHLDSSHMVLDALRLGYNSFICDLIPSQQYLDYENGVPLDKIFSKTQPEVAKGFWNRTVKSLYKSLQENTSERSRSVSTDLNTAVSFLDLETEYNKVLENLSTKKENFSFKAVQSKFNVIFEKDYYDVEGSITENCYAVDVVVDKDLDDALEIIEESKNGDLIPSLLGTPLENQDFNFLSTKKKPLIVVNSLNLKQSPSFKKLKSCFTEFFQTQNNYHLILESFYDNVVRKCESIADLKVKKVFENFQEVLKSERVIFYFFMRILGFNDSVLKWRGMRNMEKDECYYRNILTHGFSRTSKNKEMDSSNNTLPNDVSLDVSQKNSFIYNSSSSIGQAGDETNSSHTPDGKAKNDQRTVVEHLIDDSFYEFIGGNLNDAIVEVVEKLETIGKVSDRVEKIFAFFNQYVELMDKYKGFFTLYSMHDITPILESKKVSLSEFEGGLEGVFILPVQRMVRYKQFLEKFYKYVDARFISEQFTDALTKLSNFIFELDRERFCFESGRKAFIIQKKVENCPPDILNVKRAFKRQLNGEIARVVRLSFFLYNDILMVAARSSDETDIFKESDLRLRFIKYIPLQNVRIIQIAKNTLKFIFTEEVTEKNLANVPGSRVINTGDDITETFVVSVKDRGVNDFLKEFFFFRNNDYSMKKQSKMFFDMIENTFVFYHVIEYDKYQRVGSSVVINLSNREVSKGKERKTVGKVNTEIGKFLISKEKLIWTIRKGKVKTNAVHECAKRDSSGNVLPRNHGNRSPDEVLIEQNVIECVVYSSKRIKIQPLIMTSSEFKAKFKSLFLKSMLINSQFFPWEKKRMLRCAAISWSMSNRRITVCAYQAITNLLIPIWQCSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXX4</accession>
    <name>L7JXX4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0718"/>
    <dbReference type="HOGENOM" id="CLU_894830_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXX4"/>
    <dbReference type="OrthoDB" id="10392499at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="311" mass="35243" checksum="F67978569E1E348A" modified="2013-03-06" version="1">MEFINNRSSKIGGMPKTTSLLEYMKDESSGKDSSPEEVNNLGAIKKFFGSPGINVGDYYEPWFYMSDGFLRLVRSEFGKIEEGRPLFLRLIPDNDFSEDSQSYPSSAVGIDNTSAHCSVQFTLGENILPKESDQTHESHDESLDISSTGVPTSICISDLINRSAVIELFDYFEKLEHRLDPRLVRGIFCDQDRFKLGNVPATNIFIDNKLLIAQHRSSIRRREQQNKLVIGNAELVIDKNMKFNGDNFKLTMFVCSEIIDNVSTLKLYTLNSNGRWECISPTSRLRKSANEINQILENTANIFSLCYSLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXY1</accession>
    <name>L7JXY1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0729"/>
    <dbReference type="HOGENOM" id="CLU_3279802_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXY1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4907" checksum="CFEC5E6C8E458247" modified="2013-03-06" version="1">MELGDEMKNIDLNYVHETNDAFSVQQKFFLLRGPKQFIFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY68</accession>
    <name>L7JY68_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0605"/>
    <dbReference type="HOGENOM" id="CLU_3360008_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY68"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4380" checksum="4820876F3AB79E07" modified="2013-03-06" version="1">MCAKKIFDLEILIVETKPREFFTPPKKKERVVNRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY69</accession>
    <name>L7JY69_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY69"/>
    <dbReference type="FunCoup" id="L7JY69">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1004"/>
    <dbReference type="HOGENOM" id="CLU_027280_4_0_1"/>
    <dbReference type="InParanoid" id="L7JY69"/>
    <dbReference type="OMA" id="MIVFEMG"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="355"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="426" mass="49526" checksum="A836A07D614D23AF" modified="2013-03-06" version="1">MAVPEIISFLSQKVDLSQLHSDPLFSIALLKILGNPTKELLFCLLTTNLNIKNLNTNDDKQNKEIITNLRILYLLKLIQKNNGFILLDNNFRSGFVASMKLVRVNNYFEAVSCTNTADTVSFDNILRMLVNDRNAKVNEVVLDVLQYAKLVNIIKEITHSGFEFLLKSRKEQMWFLILNGILMLGKNYVDWLTMIVFEMGMYERHCWLKINESKIFGTARKHNKNTNIDPVSDKEAHSVLVRLLKYLSYLGIIQYSNDMVKPTAEYFLLFSSAAIQDSFLIVETNYKLYAYTTSSHELSIIKLFSQIVRELPNLVTAHITEESVNAAFLKGITGQQIVDYLTEKSKSELPPVVLEQILIWERQRDRMKCIDAVIYSHFMTYNEYEITYRYCREKGALIDHDEFRRLLVVRLECHNEVKNFIKNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY79</accession>
    <name>L7JY79_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1014"/>
    <dbReference type="HOGENOM" id="CLU_3074554_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY79"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="53" mass="6240" checksum="CB3DDE20F152CDC7" modified="2013-03-06" version="1" fragment="single">VPVENNGMLNNEKYIAHRTDRTKSTNTELSIFSIGDALWMWFYFSVDEWLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYB2</accession>
    <name>L7JYB2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0745"/>
    <dbReference type="HOGENOM" id="CLU_1836533_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYB2"/>
    <dbReference type="OMA" id="HMSETHT"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="140" mass="15859" checksum="64FACA70DFEBB29B" modified="2013-03-06" version="1">MVSILNFTNQGNISFSSRGTPITHMSETHTLTHEELVAKNISEMIRECGFRNTVDSALDEIIRTHPKVFICVIMFLYIIAILLLGYGIRYARKSFKKSCDLRSGRNQDIGVFAVKIDSYNNENEIYTVSNSYGGIKTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYL5</accession>
    <name>L7JYL5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proliferation-associated nucleolar protein (NOL1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYL5"/>
    <dbReference type="STRING" id="72359.L7JYL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0592"/>
    <dbReference type="HOGENOM" id="CLU_692961_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYL5"/>
    <dbReference type="OMA" id="GSGIHND"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="121"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="398" mass="45605" checksum="D9E225978893DFA9" modified="2013-03-06" version="1">MYEHISVKLQKIMNNTHKLSYYRKDEHFKLLRGTITNRKSIETIISLSGYKPRNKYASMLMVQDVVYNGKQEGTNCNFVKNLVIPSQYVRINTLAEGCTYNGEFNYNNGKKETDTTRNETLPDNSTLSDNNYNKKNDSETGKRSHVHGYLLNHEQYNLITSRELQSTAVPFVYKVPLSVHLRLSPARQYIIQSLPTTLPPYILNPPFNSTVIDTCASPGNKTSHLSAIMNNTGLIYAVEKDFKRYKILKQNLELCNVKNVKTMNNDFLELNLNAEYLLVDPSCSGSGIHNDYVKNHNRVKLLSSFQKKILIHALNTSGAKRVVYSTCSSHKEENEIVVDHVLKDEKLAEMWRLDEIRCPYGTKGIEGYLCSESVLRFERGEHIGFFIALFVRKNANLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYN2</accession>
    <name>L7JYN2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative chitinase</fullName>
            <ecNumber evidence="5">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.2.1.14" evidence="5"/>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYN2"/>
    <dbReference type="STRING" id="72359.L7JYN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0612"/>
    <dbReference type="HOGENOM" id="CLU_032939_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYN2"/>
    <dbReference type="OMA" id="LTWPANY"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00325">
        <property type="entry name" value="chitinase_GH19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595:SF79">
        <property type="entry name" value="CHITINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595">
        <property type="entry name" value="CHITINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 19 catalytic" evidence="4">
        <location>
            <begin position="431"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="589" mass="62922" checksum="3B3B2238E64F96B3" modified="2013-03-06" version="1">MLILQLINQIRSLCLPGSSECEGDTMKMCDLNGEWVVIDCPANSQCILDNNKITCSPAKENESLLPEPLASNKNSGQQESGTDKKEDKEKEIQNSTESKPSDQKKTENQSNIPNSNSSTAENKSEQPEGTQMPAEKQSQPDESKNTENKAEPDKKDEPKPQEQPKPSEPPKESVKPLEDKQERTITVYKTVTEKIMIETQDTAPTMQEIVKTVKRPDLPCCDEDLQESCRICRDTKPIRAIVIDRESLLGAASEKQQGPSAGTGSGQPTTGGSDTSGESSPPTTQGENTAQPGGGSGASQPAQGGASEGGGAQQSSGPPKSPPGHGKAPLPASNLTSANKNSKTPAPSGQTKKLPVENLNKDNKKSTLKGKEDQKLADATAGSQSSSSSGGGNAKITESQIKQVTSELGYKPPDANVKAVADQIGKFKTTNEAAMFLAQIIHESGGLVQLIEKGCEQDQAKCGKNYDDGQGKPGKYYFGRGFIQLSWAANYKAASEGIGMGTKLLDNPDQVGKDPKIAMQTSVWYWQTKVANAPGVKENKFGATTKAINGALECKGQNVDKSKKRYDIYKKVVKVLNIKNPASESGCYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYW9</accession>
    <name>L7JYW9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0782"/>
    <dbReference type="HOGENOM" id="CLU_2475143_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYW9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="88" mass="10406" checksum="DDF8CEE0B8B2AD24" modified="2013-03-06" version="1" fragment="single">VKRKSIEESTSDGLYIRFSMHTRVFNIVVDITNDIKILIMKNAKIMMSSYSDENISRYFSELRRKLAHFMKHKGIGKGYIAKTKRKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYZ9</accession>
    <name>L7JYZ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993838">
        <property type="protein sequence ID" value="ELQ76555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0468"/>
    <dbReference type="HOGENOM" id="CLU_2544216_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYZ9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="83" mass="9893" checksum="44D8140E92EECD46" modified="2013-03-06" version="1">MYFVGEVKPVIKKCMDEFDEDEKNNFIDVVRGWLSDSETKFEKKHHSNSYNVIWQAVLQKIDEDENLFDVKAARDVMEHIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ20</accession>
    <name>L7JZ20_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ20"/>
    <dbReference type="STRING" id="72359.L7JZ20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0741"/>
    <dbReference type="HOGENOM" id="CLU_185702_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ20"/>
    <dbReference type="OMA" id="KAKPYLH"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="9078" checksum="ACACC3C3759C5ECA" modified="2013-03-06" version="1">MNEQPLYVNAHQFNCIRKRKLRRDFLDSITRPKSVNGSGYLHESRHRHAMNRLRAPSGRFLTKEEAKEVRMKERKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ49</accession>
    <name>L7JZ49_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993887">
        <property type="protein sequence ID" value="ELQ76042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0993"/>
    <dbReference type="HOGENOM" id="CLU_1180920_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ49"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="235" mass="27857" checksum="3983311757853556" modified="2013-03-06" version="1">MYLHLEGIEFGYNFNVPQRVKTLHLKNITMLSNKITRMNRDCVTIEVQELQGIIDTSEARSTKGVTFHSQLPRFTDNEWNYFSRAEKAWYFENDKEIIRLPNYLRTINLMNIKQGKSLELIIGEQCEELSMISWSCDFNLFKITSLHRLTFYPTPYSDINIKPLYTRRIEELDIAYNGIGKYFRKFLVKCSSVKRLTIHAWNTDRQEFEMERIGDIGMYGCTDIEKGRIENAYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ79</accession>
    <name>L7JZ79_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993817">
        <property type="protein sequence ID" value="ELQ76753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ79"/>
    <dbReference type="STRING" id="72359.L7JZ79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0246"/>
    <dbReference type="HOGENOM" id="CLU_379555_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ79"/>
    <dbReference type="OMA" id="RVVQHMH"/>
    <dbReference type="OrthoDB" id="2404674at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978916" evidence="3">
        <location>
            <begin position="19"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="484"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="730" mass="86542" checksum="90477B892EF59D69" modified="2013-03-06" version="1">MTAAHLTTSLALALEVHALRAMNEKLYMKMSILRTMRRMDGCVRRRYDDVVRIDMMRECVGRRIKEMRRRMDDDVVVMVELMDGRRVYDGMDGRRVDDGKEGRRTRDREERRKVDDGMDGHRTRDKEEGQGLIKNGHRVRDGIGQERECVEKSFYRVVRRNPDIPNVEHEKNVLSMEHKEEHKNKNIKEKIKRINKDGKDAAYKLTSTCSSPHLRNYKRLNEYASFPFLRPEECELLIVKRGIAQSIEIIRTVINKEMDVFLAMMTEMGVIRVDRKRRARVNANVEDRGFIVGLDERCGGNGNSAYYGQMNDADAKALREQEKRVVQHMHEYISDGRGFDKQRVAQRMHEDSDDGRGFDKQRVVQQMHEDSNELNRCRLAVHRQLLKLRECVAENVLKSFERLAQRQITGRINTHGWIARYGSKSGKKRLIMKMKEEIETGDGRTIRERTMHRIKLKIKRTLLFMHKNTLRNCLLCVMRIDKECEEERMKRMVVEKKYEEIRNREEGLQKEMHAVRIGENSLREQYEEIKIREGKLQEQYKEIKIRESELLKEMHEQEITNVETRQRYEEDKMKEIELQKVTHEQEIQMMHEQYEIEREETSALVAQKLKACHALKGMALRVLNNKCIAYTCIDIERNLYRIQSNIFYAEFILLNAIHQSLKMVVRTGTIENDERLVDVINSSLRDIEGFKSPRFVKMSVELEISKRYVKDLIKIKKVLKMFSLYSEEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZA4</accession>
    <name>L7JZA4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0222"/>
    <dbReference type="HOGENOM" id="CLU_3260840_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZA4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4996" checksum="2E7A638B9A640FCC" modified="2013-03-06" version="1">MVKMLRMLWKVKRMVGAVKGNDEDVEDVEDDEENDRNDENEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZJ4</accession>
    <name>L7JZJ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="JH993826">
        <property type="protein sequence ID" value="ELQ76725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZJ4"/>
    <dbReference type="FunCoup" id="L7JZJ4">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0279"/>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="InParanoid" id="L7JZJ4"/>
    <dbReference type="OMA" id="MFPEVVF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="310" mass="34992" checksum="C4704A6F45B48BC2" modified="2013-03-06" version="1">MTLPKIHIKINNHTSTSLQLTISNAPLPFLNALRRTILEEIPAVAISKIIFHKYVGIVPEEVLAHRLGLVPIFCDALLLVDSAVPTRNSCVRMRIRKRGADGGVWVRSDDIEVVHFDSGRRMCSWSRAVEEDDGLEEVDGDGIANALDHTYNANLPMIKPGVLITKLGPNQCLDAEMYATRGTAKEHAKYSSVNICYYRMHPILTLNRSFKNEDAHLLKKRFKDGVIGIRRKGKDEEAYVMDDKEVIDVEDIEGVSVRMDEHCVLFYVETEFIDPWEVVKRGLYVLVERSKALRRDVGTYLNGGQSTVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZJ8</accession>
    <name>L7JZJ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA helicase PIF1/RRM3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993826">
        <property type="protein sequence ID" value="ELQ76730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZJ8"/>
    <dbReference type="STRING" id="72359.L7JZJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0284"/>
    <dbReference type="HOGENOM" id="CLU_1850027_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZJ8"/>
    <dbReference type="OrthoDB" id="2272314at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="139" mass="16384" checksum="28F7062D22569893" modified="2013-03-06" version="1" fragment="single">MGANVQQFTQGVHFFKIHGQVYHNTYNINPLENVERRYSQLYVIDSDNATDLRSKNPANEKCDRAILYNLDRVMREVNPYAEAFKNLAEVERNARQEGTTLMDLNMVFNANIHSNMNMNEYPEYRRENLFILGMFLKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZN5</accession>
    <name>L7JZN5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription elongation factor TFIIS/Cofactor of enhancer-binding protein Sp1</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZN5"/>
    <dbReference type="FunCoup" id="L7JZN5">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0209"/>
    <dbReference type="HOGENOM" id="CLU_037637_4_1_1"/>
    <dbReference type="InParanoid" id="L7JZN5"/>
    <dbReference type="OMA" id="FCKCGNT"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="7">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="181" mass="20895" checksum="EB81C613B86C21FB" modified="2013-03-06" version="1">MVQIASDQNTKKGEISTQEALSQFAKGDQSRDRTTSLFYEVFVSIINDVDKLRAARLASDLEQEIYDNKIVSSQIRSKYLNLKDKSNDLCVGIYEGRIGVHEFLLMSMDEMKSKARRSSDNDLIKSSIEGSQIAQMEVETDIFFCFKCKQRKCRYRQIQTRSADEPMTTYVFCKCGNTWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZP0</accession>
    <name>L7JZP0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SCF ubiquitin ligase, Skp1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZP0"/>
    <dbReference type="STRING" id="72359.L7JZP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0841"/>
    <dbReference type="HOGENOM" id="CLU_059252_4_2_1"/>
    <dbReference type="InParanoid" id="L7JZP0"/>
    <dbReference type="OMA" id="ICNGANY"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="139" mass="15565" checksum="C755E626039FC4FA" modified="2013-03-06" version="1">MQLDVMTTDKRVYTIPDKMVNDCILFRDIANLTDQCSPISILVHSSVLEFIMGFSEINTLNLPENYDAAQIVFAPAVFEFINALDFQTLSDICTAANYVHYPALLELCCKVISKKLCEVEVVTGETANELTWISSDEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZP9</accession>
    <name>L7JZP9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993844">
        <property type="protein sequence ID" value="ELQ76526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0486"/>
    <dbReference type="HOGENOM" id="CLU_2238495_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZP9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="105" mass="12360" checksum="B593CDC76EDDCB01" modified="2013-03-06" version="1">MDLISGFFSTKKLHPVMPENQKLNFEDFEFKNADKPSTVPNEQYNLKNIIKEDVYRDNEHYNDESVRMDALIPEKCIGKNHYCCHEKRQAKHIDDQAKEDENSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZT6</accession>
    <name>L7JZT6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase 2A, regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993837">
        <property type="protein sequence ID" value="ELQ76556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZT6"/>
    <dbReference type="FunCoup" id="L7JZT6">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0450"/>
    <dbReference type="HOGENOM" id="CLU_596093_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZT6"/>
    <dbReference type="OMA" id="XVMFLGE"/>
    <dbReference type="OrthoDB" id="2195607at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="459" mass="54845" checksum="52262B17A7FB26F3" modified="2013-03-06" version="1">MSCKRLERKKTRRNSGTPRRDMKGKQEMKRKRGEKGFSCEMSTRTGIFGRRETASEKELPISCTFVYLKSLETMLFQDNTMFEEEKAILCKLKEVFLYTNEEKKKTIEMKPFTGEHAQNMNSQQSLLEYAIEIFRRYLGSQKCSITVLKSAFEEREIENFFAKIKTVTVKARIMIVRCVQILLLKAVEYRYLLKNCIYNELVYYIENGKNLKCIDVLLDICAFYVLKDIYHDMHELRYFLINYVLPLFTNSNAFCYRDDVILLFTSICYCSDSFMDMVFTHFSKIFFETNTPTKTLIMEITLKVLNEKCRDMYPYIPMITEFINFALKEQNSALIVIMKLLFSLPVLFLSLKRNIAHFLPLIFTNLYKTSKNYWNVEERCVLYEIISNIMIIDKDLFDWCLMNYNKERYGAYFDRKINEDVINIDFINAKSRAFDENINERRTSVYDVEYEELKRFKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZU3</accession>
    <name>L7JZU3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0768"/>
    <dbReference type="HOGENOM" id="CLU_391904_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZU3"/>
    <dbReference type="OrthoDB" id="2190283at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031541">
        <property type="entry name" value="HTH_micro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17007">
        <property type="entry name" value="HTH_micro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="704" mass="80826" checksum="41B5C2F16442C4A7" modified="2013-03-06" version="1">MLGDLKEKIFSYGIFGTPCSELSEEELFALLSEQWVEFVTGEQIAELHSSFTTLALESKQKEIMEYFEKQRMAGNKKIRYEGCALYGPVNDLTGRYSAVNGFNTIRDRLNYGSTAEYGTVGKSAGSSVQQLSPDDKYLLRLLLVNLYVRMNTVAWKEHLTNGSFNFTSKEYYYVFDMLIRMNEYVSVSNMRVTLGIEPKKMFYIIKKLVSLGYIDKTAEDNKIVVKIRRDESGNVVKGRPKEKRRSINSEDTITDTSVTNSFDEQHIGMDILIGVPLITQIKKFIERSRTGVCSKDIQDRFGIKLKIGLKLLNKISDRMEGSIKTVEEFEGKIKRTKFYNVNELSKLKERKRQRMIAREQSVEEGITMEDRINAIEQILSVKKAFVLDKEFFKDFRSILGCKYTLDRRTVINAAIKGGFNVYKLHDDAQGAKFVVARKDVLQDDPSVTNYYPSRKTASTLTPFQSQLHKFFVTHSKFAEIDNGFEPVLNKRVKALYSFLRRLKENEFYFNCDVLQSMSLGLFFKLVSFKRYKFLGELIEIIKMKRNSRDEERRVAEERLIDEKENENYTNISRVYVKERNRGVSAGGDVHGGVAVADIDLQNGNRMEMGNGVINGILQNEERIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKTLNLKEQCPTRKQGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZW0</accession>
    <name>L7JZW0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZW0"/>
    <dbReference type="FunCoup" id="L7JZW0">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0290"/>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_1"/>
    <dbReference type="InParanoid" id="L7JZW0"/>
    <dbReference type="OMA" id="DWYRQLW"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="530" mass="60903" checksum="6446D38B3F555C15" modified="2013-03-06" version="1" fragment="single">VFKYAEDFGDMVDRTLITLLDLFKNDPVRTEKFVRKVNVGDEAIYFDYSKTHIDTMLLHELNRGFRSTETRKGMFKKEELNFTEHRKVLHIALRDKNVLEAIEKNGSGDKLGEEEQLVFHELKKMRQFERKFEEGELLGVTGKKLRTVVNIGIGGSDLGPRMVTEALEFYKKDNVKVFYIANIDSTETERVFSKIDAEETLFIVVSKTFTTLETLANARLALKLMKERLNVDEREITEKHFVAVSANKEEVVNFGINNCFDMWDFVGGRFSLWSAVGLSIILYIGFTNFLSLLKGASIMDEHFKNEITEKNVPILQAYIEVYYTNFRKYESRCVVAYDEYLKNLYLYLQQLEMESNGKMATFSGSVSWNTGMVLWGGVGTSAQHSFFQLLHQGTRRVLVEFILPLQPLGDHKVMDHSHFEMLFANCVAQSQALMVGTETSNNNKYFGGNRPSITICYTKLTPAVLGALIAFYEHKVFVQGLYWRINSFDQFGVELGKSLAKKVLEYIDDEPKDVDNSTKNLIELYKSLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZZ5</accession>
    <name>L7JZZ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0642"/>
    <dbReference type="HOGENOM" id="CLU_958324_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZZ5"/>
    <dbReference type="OMA" id="YPSEMAV"/>
    <dbReference type="OrthoDB" id="10412684at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="291" mass="33025" checksum="B58F448B6CD76DDA" modified="2013-03-06" version="1" fragment="single">VMIQCYLSKTQTITDSEKRSTHSTSDQGCDQQHNESSSRRNSPVNDANQQVYNNIAQHLVPLSHIPGDQFLNIINSYKKVFYSEDEYIKKMMSFLKSKYPITDIQACIDVISTIYNYFNGNMNRIVIVLAHSIFTTSGFTRLINLDTIHDPYGCKGILQFYGMSNYELASDNFDFVSQPDKMAVLGTTSTIGTLQGYSKINFGNKVDYFFESLVGLNPGEVQVLNLNKESTKTKIIERVTVLNQIKNLFRIPILFAESGLHIPTEIREILQSMPDITFNTDLRSSEPIIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7K025</accession>
    <name>L7K025_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0622</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K025"/>
    <dbReference type="FunCoup" id="L7K025">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K025"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0622"/>
    <dbReference type="HOGENOM" id="CLU_406631_0_0_1"/>
    <dbReference type="InParanoid" id="L7K025"/>
    <dbReference type="OMA" id="KIDANTH"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="106"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="639" mass="73788" checksum="4261681090D28EB8" modified="2013-03-06" version="1">MRFKTNIQGIIMSYKEFFMENWQEIIRIFFELTIVGFFIKFKLFHHKSNILVLSDQEVQRLVDSFAPSPLINTDTDSKVKYNFGTMIEMADYDFFSICNYFKDEIKQTIRHYGVGTCGPPGFYGTLDLHLELEKKIANLVGLSSAILYCNSFTCVNSVITCFCRRGDIIFYHRCSNEAILRGLYATKATTIEFDMCTLEEKLSRYVNRKQRNFIIAEGLFRNTGKILDLPKILEMKRKFPLRLIVDESLSIPLLDKHGISTFYGTDVNDIDIIIGSFAHTFCSNGAFAAGNMHVVDYQRLLAPAYCFSASLPAFLTKFVLLALELPFHLFDARRIHEEFRSIRYTIISDKRSPIIVIRMNDTGKNELKNAIDKAEIGLESYEFAKACRCMEEDSTESEYEKNDDYNTRKIDFCGIDGQPEKQNAIFAQDEETPSSTTARQGHNLNMKNKLQENTDELIIRLNENDEDENNRQEKMEEMQKEHALRANYGYERVIEDCCAAHTKTDTPILTRKDKQGVANCEEEKKRFDTKLYTSKSRINTLNNLRYSTKLSQILREFDLSSTDLDKIPTKTAKATYNTEERFRIALLLTMEKKVKEFAKKNIRVGLVTNPEPGIRICVKNEMSTDVVEKVIKCMNVILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7K060</accession>
    <name>L7K060_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K060"/>
    <dbReference type="STRING" id="72359.L7K060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0432"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="L7K060"/>
    <dbReference type="OMA" id="CIVNYDI"/>
    <dbReference type="OrthoDB" id="2194948at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="50"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="223"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="440" mass="51170" checksum="FA2D150EEBB5BC7C" modified="2013-03-06" version="1">MSSLLKYVPLPKKQLKPKEKKELSFYALSHRMNQIYIPFKRPTKVQKEIINAILNRKSAIFLSNTGSGKSYGYSLGLAIRYHREKGKKLRAVIVLPTKELVEQMYTILKQIVRKTIRIVSLSSAFPEEKDRKKLENDPEVVVTTAGRFKLVSNFNLLILDEVDLLLREGFAIDEIRNYQLIGTSATFNNKYNDFLNLEVVNVQEKIEKNEINLYMRREEKVGALEVLFDRFESIIVFASSRVRVEEIVLYFKQHDKFKDQIDGIHGDLDSQFREQNCLSFKRRQLRILVVTDVASRGLNMNATCIVNYDIADEESLIHRKGRIVRGGTVVSFFTFFELKFVHSELFAVGQVRTKDIHECAEKSYEKMKGMIRNTTNTESINIRDLAVHSLFTEAKPATNEVHRCDLKAALRNTIDTYKKEKKAQKIENKFKDQFYIPYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7K067</accession>
    <name>L7K067_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993824">
        <property type="protein sequence ID" value="ELQ76731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K067"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0274"/>
    <dbReference type="HOGENOM" id="CLU_2387720_0_0_1"/>
    <dbReference type="InParanoid" id="L7K067"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="94" mass="10940" checksum="C884FE2FF0AEAD9F" modified="2013-03-06" version="1">MSNLMIEETINFGLEIQDFKFINIILSGASHISFDENFNELELNGCKGQFIIPGIFSDDESRTITMDRNVKRFEIRRTKNDFFNILIAIFQLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0J8</accession>
    <name>L7K0J8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0J8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0144"/>
    <dbReference type="HOGENOM" id="CLU_1504494_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0J8"/>
    <dbReference type="OMA" id="YNGIELC"/>
    <dbReference type="OrthoDB" id="10368747at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="179" mass="21178" checksum="2EF9018B9EAA63EB" modified="2013-03-06" version="1">MHDDLLQVSCLKSNNIKETKTDINGHPFIFPIDPTSFELYRKSLSNFDKFYDFISDITSTTYKDIAAYYRLRHDLKDLEYLVMEYNTLKNKLDKDEKEDEVIYYNEEEERGLVESSKMVGNSNISCMFVGPYNLAMFYKQIGNGKNLVRFMKEAKKSVMMRGNYNGIELCQNELRKYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0K6</accession>
    <name>L7K0K6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0K6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0093"/>
    <dbReference type="HOGENOM" id="CLU_2607709_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0K6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9104" checksum="4E73AEBDB9BF177D" modified="2013-03-06" version="1">MSVTLPQRLTSAIMFGWLVGVYPNMVIFSGAFDGDGWVVVDWMVVWGMRDGLDGDFFWVVVWWKKEWWNVLSAMKGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQS9</accession>
    <name>L7JQS9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994104">
        <property type="protein sequence ID" value="ELQ73813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3275"/>
    <dbReference type="HOGENOM" id="CLU_2326498_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQS9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="99" mass="11589" checksum="ABA89660336A7723" modified="2013-03-06" version="1" fragment="single">VMNIKTFLSKHKNINMEEIQRPTIFFMLLAMISLISMTHIVQQSMRDDEPVKNTEDAVNKSWGVELRVKSLGNNEFVKKFGAKCYEIVQIVENFQLYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQY1</accession>
    <name>L7JQY1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate-transporting ATPase</fullName>
            <ecNumber evidence="2">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.3.27" evidence="2"/>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3253"/>
    <dbReference type="HOGENOM" id="CLU_1723615_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQY1"/>
    <dbReference type="OrthoDB" id="1631570at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="1">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="152" mass="17346" checksum="3495B992644B5E1D" modified="2013-03-06" version="1">MDTHSSLYKISTLSKNKLDQLIGAFKNISNTPLLIYGPTGTGKSFHIRSIAAMLDMQLEYVMEPDKFSGKTLFKKHVIYIDTDDIRDLRNMPRNNVVIESRCISSVGRERNAMLIKFGKVSAIKIRKVLREYTESTTTTRRLNRACTTNEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQY6</accession>
    <name>L7JQY6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3224"/>
    <dbReference type="HOGENOM" id="CLU_1435383_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQY6"/>
    <dbReference type="OMA" id="KCAGFYS"/>
    <dbReference type="OrthoDB" id="10511226at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978736" evidence="1">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="189" mass="22246" checksum="70C4600779A768DE" modified="2013-03-06" version="1">MVVLFLFFVSFARFAHNSGADRSLGLFCPQQDFFTNSTVETLINEYITDLSKSSLNDNTIGNCQLAQNMFNSMVDLIDNDRVVYKEELRDQFSITMSILENLKFTTKCAGFYSILHVLLTINIYYYNYMTTAAVKLVKKELREKMEHNFKISRHIFKIYGHNDRMSTWKKHKEELEYIFKNIFQVASTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRE0</accession>
    <name>L7JRE0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_3040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994082">
        <property type="protein sequence ID" value="ELQ74038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRE0"/>
    <dbReference type="FunCoup" id="L7JRE0">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3040"/>
    <dbReference type="HOGENOM" id="CLU_002265_2_0_1"/>
    <dbReference type="InParanoid" id="L7JRE0"/>
    <dbReference type="OMA" id="THILDIM"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="10">
        <location>
            <begin position="568"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="770" mass="90256" checksum="298B0943B1010EF3" modified="2013-03-06" version="1">MKLLNYEKLILKECSSESHLLVMAEGLNLPKIVTTLASLYNYPDTLCLIINTDDQFDVLFADESFTSLKTSSTSKRLENYKVGGVKICQAQTLISDLLNRNLDVQLIAAIFVVNAEDVKENSVIAFILHYIALNSSNTVIKAFTENAIKVSRRYFHLNNFLDILKVRNVILFPRFQKDINDELSTSSEFIEVKMKMSGWLEEIQLYLLDLIQSVKNEMEKYNKNRVSFNDYYTHREEHSIDSDNKKKVESHVSVNVLNNISHTLQGDLSHLMRCIELLFTLDLNYFITFFSETYNYEVSHKGKTWILNSASHMIMEVIGKMKMEKGLSNKSMNKNDDDGTMNTDDVKRMKIEVEKEKNIELGEESVHENIPKNDGFIDNNEIDMDTKETIRSEVLTKSLVTVDEEEKHNLGNEDRKRCKSKFKNQKLVELKKILVEHDDEDVLIVSKYEHNKDVVLAQDMKSRIEFVKHKNLSEIKQNIVILLDFNLGTFRKIERMQKRMRIYLLYYKESHEEEEYVRRIREEKDAFERFINDKAKLGLQDFNFFIDVDEEIFDIEEKDTDLLKSKYNVLVDFRELRASLPFFLYKAKNNLRVVCLEEGDYLFDNFIVERKTVYDLIMSLNNGRLLSQMTRLFSNHSNYYLLIEYENKLSLGAYSNRNETFRNGLISKFVLLAIKFPRLKFIYTNNDLLSARLLRCLQRKEMSVEKVNNLEIDPYLLELLLSIPGINSFCVRRIQQGFNSLSEMIGSSEEKLIRVLGNERGKIVHDFFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRG5</accession>
    <name>L7JRG5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3015"/>
    <dbReference type="HOGENOM" id="CLU_385027_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRG5"/>
    <dbReference type="OrthoDB" id="10677330at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="718" mass="85469" checksum="4F10FA7BE8A52C65" modified="2013-03-06" version="1">MLLALIILSTCTTLDNTPQHNICPTVRYKFRMKQCIELEYDVGHDTFIIEIDEAYIERYKHVPGYFMARIGFDAYRSVVKSCLGIWNEFLNEVIENENEMVKSNVSRCNLVMKGWDGMWYGKMKDGCNKIMGSNSNVNRGDGESMSERGKIMRSNSKINGCDGESMSERGKIMGSNSNVNRGDGESMSERGKIMRSDSKINRCDGESMSDNQEERSDNVEEIKNKILRDSMIKNKTKMIEQESNQKITKKLRHDGIISAEEIKRFYTEKITQIHDELEKLQAIVETRPNVESRQNWEIGNVKTEKQNWINKRERRLKARQQLEKTLKLRREAQRARDTRTCDDQRIRNMKMLNRKMNKHTKELRRKIRKWRESEKEIMFELEEKMNKAENEIIPKEKAVINEEMLKLREEVRIWWCEEKEQLHDEIDRKLKLEIQKLRSEVEEKIEYCRINTELLEQRNERNRAAFEKKGEIEKASKREQRLKKETIGKLNERESEVARTLVKXXXXXXXXXXXXXXXXXXXXXXXXXXQKLGKEMIEKIIVEETGIMSEEQRLVKEMMEKAIVEEIIKATRQRLVYEEEMIENRIKEREKTMQAINDKLMREKIKREEEKLRIEVVSRLEREEKQRISLMTEQKSARMAVNEQEIQVMRKKMNGDLLVEERRLKADMYKRLKREEDELREEMRTRLEKEENVAGNGIADTKRESVDVEKFRENNEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRL7</accession>
    <name>L7JRL7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Splicing factor 3b, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRL7"/>
    <dbReference type="STRING" id="72359.L7JRL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3131"/>
    <dbReference type="HOGENOM" id="CLU_048164_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRL7"/>
    <dbReference type="OMA" id="PSHWCQK"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="1">
        <location>
            <begin position="270"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="38173" checksum="9BE8A5F99481448F" modified="2013-03-06" version="1">MAKKIKKDSFYVNNGGGGQVRSAVTNYKTNERSECTNRTDDDAMVTKDKLQDSDFKNGCCVKYHEMSGKKGVNNTVLDKHGDFEVLARDTNNGHDTGGCSLLINNGSRKKHKALKMNRKRRKHLLLQSKFEELKLIVDNPATVDIEDVSAPNPVLLNKYKNTRNAVPVPSHWKAGKMTFYTRERYEPPFVNDEALKMRETFYEHADKSTEKQREREKKYPKMTNEFLIPQETMKNMLRSAYVSSRLLRAGILYDLHEGMKIPKTDNLLENMSTELKKACGMKKCTPPPWLHNMQRIGPPPDTAYQIPGVNCEIPDGCKYGYDEDGWGKLPVGMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRX6</accession>
    <name>L7JRX6_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">WD40-like repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3007"/>
    <dbReference type="HOGENOM" id="CLU_047613_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRX6"/>
    <dbReference type="OMA" id="ATERRCF"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="1">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="330" mass="37613" checksum="7040FDE5D9FEC069" modified="2013-03-06" version="1">MSIHELRDTLNFVHSECIEHSIAVPVQHWQLRDMLKGTSRSLVFCQGNKVCRFNVRTGALDDIITDLSFFPTSISATDTLVVVGGQKGQYAVKNLENERFVLGTVGHAINNAVKICAFNNDTNFLFCNNDNTIRRYSYDSLDELEVITHPWPVNNCEVSVDGKHLVSVGDTNQIFYFNVESARFVKSRTLKSMNDGGFKVSWNATSTCFAISTQDGYVCIYDTRNLSNNMVIRSKQNRSIKGACRNVEFSKKRSLDLLIFTEHVSYFTLLDARNYESKQSIKVFDDMDKQISGSAFLEDEEKVFISMDDKIVQYKLENRRTFGSYCYDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRY2</accession>
    <name>L7JRY2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2869"/>
    <dbReference type="HOGENOM" id="CLU_3191636_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRY2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5319" checksum="12ACA0C5F274A742" modified="2013-03-06" version="1">MKLVVCTPFINTMSVYIMGTAVLVHLISKLFKVRTRFTDVFKENNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS15</accession>
    <name>L7JS15_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2835"/>
    <dbReference type="HOGENOM" id="CLU_3191635_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS15"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5459" checksum="09DAA9F5BBC9431B" modified="2013-03-06" version="1">MRTNEKLLRAHSRSQIEDETRKIEKNKDNRHNETTSNPPDVSKVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS24</accession>
    <name>L7JS24_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Nucleotide-binding, alpha-beta plait, RNA recognition motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="L7JS24">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2991"/>
    <dbReference type="HOGENOM" id="CLU_767682_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS24"/>
    <dbReference type="OMA" id="EAMNGEY"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="171"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="252"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="394" mass="44486" checksum="1A577BA419121959" modified="2013-03-06" version="1" fragment="single">VVRYKMPIWPILIKTKKFFAPMAKKQLKKQQKKDESSVTESEQSVTESSASTEISDSEESANAKEASASDEKQSDSEEVSSEEESEDASAESIKKGNKQQTSEKVEKAALDESEDSSCASSLNDASDAKEKMESGAEQEESGSDAKSSAESSSAQESNSNKQSDKSQSDDATIFVKGFDKDVTELMVEEEFGKIGKVVNVRMPKDRDTSENKGFCYVEFSNAQSAKKALTYNGKTLLDCQIVIDTPKKAGNFCLFVKNLPYTATVDDIKKVFAKYNVKNVRLPTDEDEERNRGFCFIEFNTEQDMRKVLNNKFNMDERKLFINEPKDKRDRGNGGFSRDRRDGDKGFSRGNNRERRFNDRGGFNKNDRRNAKDRGNKRYKENENKKIVFDDNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS28</accession>
    <name>L7JS28_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3226"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS28"/>
    <dbReference type="OMA" id="HENMERC"/>
    <dbReference type="OrthoDB" id="10477868at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="949" mass="108430" checksum="F1B712912FDC6551" modified="2013-03-06" version="1">MIFNLYEYANASVIFILAFQSVLNDDSYDYVICYSFKGTNMAKFLDALVEGKMKNTFYSIYDLTEASSESNTSEDAQIPHKRIKVEISNAKTRFKNHEGATASISRNKACKIIEMPFTKSLYTKAVIQEKNANLCEFTYLEIYCIFKYIFLNLDDKIWISQSICLSLQNDPEIFFSLSEYQRKIRVVKGNDHFLHKFIGNFDCDAALKRFRQIVNSSLYVRLTVEDESIAYLSGTKIVTNNLNTFSVPFKESKICFLFKYIIVEFQFFVLNADTFYDILNCNGHRSKLNILVSEIFKLNEAVGMYTKVFSLKSKLSCVSRHKLSSLHHVERITFEFSRFFSKKHRRRFNYNEYLGKIYFIYYAIDMINSVPQPAKTVKVYLSKPSIESINLVPEDVTYLKCIGPDIRSNFTFSEQFKGIIVVSLALRPGLVLTFAYGLEELDLSNVQGTIDLSNNVGFGKILLNHVLSQVSYSKKDEGGPNFFHLFYAKINTEVAVDPNMDNIIFEGITSSYKISVPLGNNVKKLNIGKSSASYDFDGNLKGCLHFNNAAVLQINTDDDSASDFKLMTCSITTPFIISGSYGNITLTDINVRSGACLTVRNDCKNLTLMDCGGVVELSTSARFERITVGFSENSSVVELVLKGAISTNYLAILNMPRNIASIFNIIGQFNYIKHLNIKNSSLEAPWPNLENHFRFRELPSPDSDFLEHDQKNNSLNKHENMERCVENAQKTTSSETLSAFFQKLVNAKVEVLEYCRVWISSYNCRFLNDMQHLKVLIGCVENLSGENMDYLPKSLRLLNVSGSYINNMTSEAEGSFKNALKALSNLEVLIVDDEFLVRPARLKSLPPRIEILVLKNCKLKKIRHKVQARKLKLRKLYISASVITSENGVILPCNPVFNDFMRSLYNYIDLKYLEELFYITLYTNYQLNPVTMQSIQEWNDTYSVDFLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS29</accession>
    <name>L7JS29_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2865"/>
    <dbReference type="HOGENOM" id="CLU_047023_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS29"/>
    <dbReference type="OMA" id="GISMEMH"/>
    <dbReference type="OrthoDB" id="2195759at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="326" mass="38352" checksum="F3B397BA345DB2F7" modified="2013-03-06" version="1">MDRDHASDEEIINFLLDNLDDWDVYEYAIKKNISLPERSTLNYLYYKFYYEKSEDVMKKLIQNISSVSELEKMNAVRPIEMLKDYFEGNIEQRLAVFHNDPSLINLKLLLSLLIGSRQENLIILALYFTYKYKNNDEYGYEIQLIHLFICRYLLYLPGISMEMHSLRIQEIQKINLSFLYHDASVFYGKKLDGVEEMVMGNLKTINESMITFINTGKFDVAISLLNLKKKLENNVIIKEIKQNKILSNEINNMFSNILGSRCAYFFNKYAKQKMQPGILKNLYNRKGTGDDYKKLLVNDYYDLKDEFEFGDAIAKIVEFQKGADDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS70</accession>
    <name>L7JS70_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperone HSP104, ATP-dependent Clp protease</fullName>
            <ecNumber evidence="8">3.4.21.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.21.53" evidence="8"/>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS70"/>
    <dbReference type="FunCoup" id="L7JS70">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2803"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_1"/>
    <dbReference type="InParanoid" id="L7JS70"/>
    <dbReference type="OMA" id="YDKSMGA"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="170"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="578"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="7">
        <location>
            <begin position="741"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="847" mass="94662" checksum="A613C66FA49F6751" modified="2013-03-06" version="1">MSTGFTSTAQKVLERSFSTAKKFKNYQIEPEHLLLALMESDIPVLEKNLTREEKSRMKTELIRRIDTLAKGNESTTPNPSSRFTNMLQDAQGNKEGVSEIDLLGAAIKCVQIEGTKKLEAVVRTVSESKTPTLDSVAVEMVHEARTTSMDPVIGRVKEIRSIIEILAKKKKSNPMLVGPAGVGKTAIVCGLAQLIAKDEAPGLTNYRIYNVDVGSMVANTGVRGEFEERVRKVVKEAEECPNIILFIDEIHTVISAGSTSGSLDFSNILKPSLAAGKIKIIGATTHDEYRKYMENDAAFCRRFVKVTINEPSVEDSITMLRGLRNKMELHHGIKIEDSAIVFSVKMAKKYIPSRRLPDIAIDLVDTACASATIELESEPQEIMNMKNKIWSLELERAAIERDYKIKSGADGKQGDAAHPEKGYGKETKERLNEVEAKIDEARRCLIPLEEAYEKERASVSEAKALKIKIDQIYNKIEEARRNNDTYQVLDLQTEVLPVIERKLKEIEGSILITSAHIANVISRWTDIPVKRLTLKENERLLGMADRIKHRVFGQDAAVDRVVQCILRNRVGLSEPDRPIGAFLFLGPSGVGKTELAKAIAFELFDDAKGMVVLDMSDYANEISITKLLGVSAGYVGYAEGGALTEPVKEKPYNVVLFDELDLAHPKVVNVLYQLLDEGRVTDGKRNVIDFTNTVIVMTSNLGYEKILTGVYDPSEIEKALNDRFGPALINRIDGICYFNGLSMVDLRNILDYKLEMLNKELNEKKIYLYLSDAVKQDVINRNYKPVYGARPLKRALRSTFMDAIAHIILTDSKRIERAEKVLINSFTQEEGLEGTIIGDYAYVVQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS77</accession>
    <name>L7JS77_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3179"/>
    <dbReference type="HOGENOM" id="CLU_135793_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS77"/>
    <dbReference type="OMA" id="QMKRYMA"/>
    <dbReference type="OrthoDB" id="10479328at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="20463" checksum="FAB625CC53E061E8" modified="2013-03-06" version="1">MHNINFSFVYSSLNPKPFIEQPLNNKKVPPEKKQILMTTRKQERNLEHREYRNNNYPRDEHYRARYASTRRPMYSAMRESARARYLPEGDGGRYEERSFRRRYDDRPYDRPRDRLYDRRERVYDRYGSRGSFRRGGSRERIPTVEVMDAQMKRYMAGEKIEAGYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSC3</accession>
    <name>L7JSC3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2772"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSC3"/>
    <dbReference type="OMA" id="WTEEGNN"/>
    <dbReference type="OrthoDB" id="10489066at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="949" mass="109598" checksum="71A308F8B8D1CC91" modified="2013-03-06" version="1">MFLTSLCDYITATVVYIFVFQSWTEEGNNEYMVFYDLKETNMMEFLVSLEAGTVDSIYYAIRDYDPKEYMAELSESTENDRFNGVCSSLTELRIRTGRNCSYFQDLIRSNMDTHRKFKVVEMPFAKSLFEKIIITKKNESLSFGLEEMLCIFQKVFLCLDRNEAVAYNMCMSLQHNPQMISNLFDPNMDLGITESYYSKKLHANEYNFNGVLVKFCEILKQNVEFYLMKDAVQIARAFSKTKKVFVMENRIQLNDLQIGFIFGCLEVSSSYLREYVDIFYEKFKSDHLGNDLTIFVSDTLPLDSILSVIHDNSTVMTELKWISELDLWRLDRLKCITCCVHTAEVYEEFDAENVEFPLISTVFPSFSVNFNESIAKPIEDITLCLKNILDKSVNDLINKISSIKLENIVFENDFVFTREFERVHIYQCEVKKECKVVFKNIYKQLTIRHTSGIFNLSGMAGFSTVEFVDRAANLEFRMNDPELPSKVRLENAQIEDNIVIDSSIDQIFLSDVEIFNTITINFNNKQQTINICETLGCINLTGLFNIKLFAAHRICLLIVPCKHGDCTLLLTTCNIIELGVLEDVFDQIRLKDVEIEEGCCFTVNASCKKLEILECGGIFDLSGPKRFTRIEIDFSSDLENTLTLRGPIKTKTLVLYNMKNSAREITNFFNEFKEIKHIMFKQTLSKYKFVLEDYSADTYQMSRLQETEVYEAPIIPSDQIQKPIIQRDKELNSANNSFLSAIFCAQAMKKIERLEYYNILMSTLNCQYLKNLQNLQALRVRLEAVTVDSLSCLPLSLKFLNITNSLASSINQDPRLVICALKVHSNLRALAIDSDLFNDPSLLLLLPNCIRVLVISYNEFKAKKIGENVTKLKLQRLYVSSYSDMIDDETYTLNEKLTNFLGTIFEYVNRHCLESLVFSSDDKQYGIDPFTLRVMEKVSQKFDVSVDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSG2</accession>
    <name>L7JSG2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2732"/>
    <dbReference type="HOGENOM" id="CLU_081169_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSG2"/>
    <dbReference type="OMA" id="EIRYFMC"/>
    <dbReference type="OrthoDB" id="2190145at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="299" mass="34071" checksum="729D4FC1EB82295C" modified="2013-03-06" version="1" fragment="single">VLFHFKRSSFSRKENGAVSFPCLLSHAVFHCGCNKNGGSLHEMLLITFVLLAQCGARNAFMVSMDLTDQELEKFNASDQELRTYTAMSDPKDPAFDHLLNLPSQEQRQPLPKCAISEETERMHTDLNSMADYINDQLGLPKDAVPSINNKKAFKRLYDWLMLHFDDLALNGRIAISLEIRYFMCAYIVAFLPAQFAFFFPRALVKIIPSTDKPIIGDFVKSLKTFLDFVKANEQGELFITFSVGRSFNSKRDFDFILAIPKKIISDPLYVLQQALMFDLKAAGLEEFRARIGEDTLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSH5</accession>
    <name>L7JSH5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2852"/>
    <dbReference type="HOGENOM" id="CLU_1355512_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSH5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="202" mass="22310" checksum="F5F35FF9E0F42972" modified="2013-03-06" version="1">MDLDPLTALGMPDEEMMNVRIDGIADRSDWLEAALQSYMMAGGEKGGVNALELAAKTYFNQSGRTDTIGLNMVDELELAAKAYLRKNGMIDTSKMNGTDVMATLAHVHPFARKFQGARNKAVQGMPGMRMTSNQLFPTTIDSFGNPYNSSIQHLDDPFGSISVLTRLDLLKMYLNGAPGYNTPSPLRHTSYSITTHRPSWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSI3</accession>
    <name>L7JSI3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_3077</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH994088">
        <property type="protein sequence ID" value="ELQ74011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSI3"/>
    <dbReference type="FunCoup" id="L7JSI3">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3077"/>
    <dbReference type="HOGENOM" id="CLU_004627_1_0_1"/>
    <dbReference type="InParanoid" id="L7JSI3"/>
    <dbReference type="OMA" id="AYSVMKN"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="15" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="12">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="13">
        <location>
            <begin position="399"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="628"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="750"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="776"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ74011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="825" mass="96623" checksum="EA3C40C161C1F668" modified="2013-03-06" version="1">MVDSQLNLSQFVRRLTKIQESISMPLLIVLGKKLEVEDFGPNSALFIYLLNYEFPETLLLITKDTCYAVTSTKKKEILESMRCTKLKVYERMKDGSRDDFLKKELLKITDSVLMSDRNNLQGHFCSTFINIFKVSDFEMGSLFVDKEEEEIEYVEGAAMFCTYLMEEAIKMVKKGEVCIESKLERHLDTPDKPFDLKLSQIEFSYNPRIVRDQDAITISIGVRHQSYSAEIQRVLFYDAENLEVYRLRNEKLRNGNFENLKSIGLLQREGLRRNENGTFVMKTDYENYTIIDVVKCTDGKFEVLTDDITWNDNDKKDFVPDDFVIIREKTNIEKKRLSRQKALEKEIEINEHQKELMDKLNDEMVRYYSDMETTEPAETADKKFIAYEKESQLPRKNKLVVDRRNFGVLIPINGYMVPFHIEYVKNCSLNGNDLRINFREGEIIKSITYRSKAANSLYNEIGDTRREYVERRETSNVGEQGTLCEIKGRRHILGDVKIKTEVRTQKKSKAGNLELHENGFKFHDTVILFNNIEHLFYQQGDAYILHFKLTVPIIFNGKKAYNVQFYKEVVENMSIDIMKLHPSQKERLEEEQEKIRQEMIKAEYDNFIKNVENNSNLRIDRVSKDVYFEGVPYRQNVQIRPSSTCLVYLLEPPFLVVDFEKMEVANFERVNYVSRSFDLTFIFKDKTFMTITSIDSRSMDYLREFIDSRNICFIQTAQNINWNNLLKTIKEDPFTFYNDGGWSALQPIREDDDQEESSASTLSSPSSVSESTMSETEGEDESLEEDVVAEEDDEDIVDLNEIDSGYESEEDEDEPPNKKRRRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSP2</accession>
    <name>L7JSP2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3018"/>
    <dbReference type="HOGENOM" id="CLU_3299687_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSP2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="5124" checksum="86562CADDFD90940" modified="2013-03-06" version="1">MRRCEKREEETKNVKRENKEDEIKQKKRWRKSACRILRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSR1</accession>
    <name>L7JSR1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994046">
        <property type="protein sequence ID" value="ELQ74335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2743"/>
    <dbReference type="HOGENOM" id="CLU_2312987_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSR1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="100" mass="11415" checksum="46F84DD07F90849D" modified="2013-03-06" version="1" fragment="single">VAYEEVIEKIISFFTSFEGVHCENSSTTLKNLDEKSLDNLKRRLEPATGRPATAPPVKRFNKIFQRYIADRKTEDLELIVYMKKITEQNTLPGVPPPGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSV7</accession>
    <name>L7JSV7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994037">
        <property type="protein sequence ID" value="ELQ74514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2558"/>
    <dbReference type="HOGENOM" id="CLU_613349_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSV7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="447" mass="52217" checksum="25F6728CE97623E8" modified="2013-03-06" version="1" fragment="single">VNVSPYQQPRNRYSTPKQSKLSRHMTNQSEQPHNEQLQTTAESLYDILKCYAKPKNLIEEMNLRTITAALCRNYIENLRHILSVERQYSNVYKMYNIDGFLRIPFCDLSKGKIKDANSEIAFCAVIRGIAHSCKMKMDKRTEYIRLYGSPNEYEELTKMVKVLLKKVKDFMKRSDGKNTHNESYSMCTSSFESNHKERDMTKHDLAKYETNKSENRVEDMTSNTGVSLTKLSLPADVTQSSDSPVYENEMNWPHADIQRNVKPVIQENAVTDIQPIISTDEKNENFLFVSSNPPCTTHSSVNKKVANESNRTQRLRSYSVSDIDDKLFPRLFGTEKKEKNDISSYMHFFLPFSNIHNESEKNKVLPIIFHLKSIDEKSTMKKVQYYFNQIRLEFLGSIYKYSMLLKNEYQKDCVRLNRFIESLRKYLKTGNNSSNQERHIAFDFVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT36</accession>
    <name>L7JT36_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab6 GTPase activator GAPCenA, TBC domain protein</fullName>
            <ecNumber evidence="3">3.1.21.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.21.4" evidence="3"/>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT36"/>
    <dbReference type="STRING" id="72359.L7JT36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2914"/>
    <dbReference type="HOGENOM" id="CLU_005350_10_1_1"/>
    <dbReference type="InParanoid" id="L7JT36"/>
    <dbReference type="OMA" id="EYQIHVD"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="75"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="330" mass="38532" checksum="D817DF573EF7A562" modified="2013-03-06" version="1">MAKSSAKENENSQARLLYQFPKSTTRNLFTDTFGFITKEKETVSSMHSVFKLKHRWERILTEEKAECMDGMVFKGVPLFLKNRVWTYMLRSRKKYQEVSWEEYTRLRDEYSGFEYQIHVDIQRTFRNHALFYDAFGEGQCKLFRVLVAYANYNPHIGYCQGMASFTSLILMYFDELEAFNVLINILSTLNALFDAQLSLLPTLMSVQKEVFILVIPEVYYLLKNENVDLCLFVYSWYLTLFSRFDIKLSLRIWDIFIFYGTASLLAVSCAILSFYVRRLGEMHGESLVAFLSSLDGIVLGESDVDSIIEKVKGVMEEIDLDDINNMLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTA3</accession>
    <name>L7JTA3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Flavodoxin/nitric oxide synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTA3"/>
    <dbReference type="STRING" id="72359.L7JTA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2402"/>
    <dbReference type="HOGENOM" id="CLU_2484917_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTA3"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="87" mass="9887" checksum="16825E792B37819D" modified="2013-03-06" version="1">MSVQIPIVYGTQSGNSLHVSQLIRSKLTHYTTHIVPVDEFLLENFLNCNTFIFVCSTYGNGDFPFAAQYFYNCLVSESVPNDFLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTD7</accession>
    <name>L7JTD7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3055"/>
    <dbReference type="HOGENOM" id="CLU_704344_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTD7"/>
    <dbReference type="OMA" id="NIHYNDI"/>
    <dbReference type="OrthoDB" id="10475326at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979123" evidence="1">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="392" mass="45529" checksum="5CCDAA9F647230ED" modified="2013-03-06" version="1">MLTATYMNVLLLIPTFISASGIDDSTPTVPIQLPWNTELNSGVISYYKDVIKRKSEVFPKFIFMAYLSKSEENQSNVENMILKMKFYANNLRLINTNFSDYTLRVKEVIDSLLNDSVVEAAFPIEFCILQHIAKKMTVPSLPTPNCTLKKHFEFIQFKLEIVDFFNLLYSKMITYTIFSQYVNAIETSSCFLSYSHDYIFSERVNVEVALNRLISRLCHLLIDVSGHLPRFKRLSMNVKRKKQELLSNLINTVREQINTINMPVNTFVDADLVVKYLKLITDCHNIYQSILKVHRLIYNEEFVDKSTISSEFISLYYHYKGIYIFYNDTSNHMLFKQMLNLTQELYNSVIYGFQHVVIYALNVHKVATALLTKMSEITQIPVCQVVSSEIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTF2</accession>
    <name>L7JTF2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 26">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 27">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">THOM_2398</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTF2"/>
    <dbReference type="FunCoup" id="L7JTF2">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2398"/>
    <dbReference type="HOGENOM" id="CLU_011815_2_2_1"/>
    <dbReference type="InParanoid" id="L7JTF2"/>
    <dbReference type="OMA" id="DSPEGNN"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000526">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="16 30" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 30" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="29">
        <location>
            <begin position="113"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="28">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="ELQ74674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="383" mass="44928" checksum="10E7348DC526F646" modified="2013-03-06" version="1">METKEIHTIDDLGVGYKLCVKKDMGNGTENIKAEILGIKNKRKKEFYVHYINFNRRLDEWLNGDSFVLDTVEVPKKRKKSYAKKSKSSLDVTASVTKEDESVVTDAFNKSEEYKLKVIDKLHIKDKIIDAWYFSPYPEDITGIIYLCSFCLFYFRTKDELRVHDCHLRHPPGNEIYRKDNLSFFELDGHIQKNYCRNLSLLSKLFLDHKTLFYDVDPFMFYVLCRLERDGYHIVGYFSKEKVCSQGFNLACLLILPYEQRMGYGKILIDFSYLLSKKENVIASPEKPLSDLGLIGYLSYWREAILEVMQVDSNGISVEEISSRTAITVEDVCNTLIYYKMVKFYDGELIFVKDRNVKPRKYKVDEKCLKWKGHAFNQNCLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTI4</accession>
    <name>L7JTI4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994024">
        <property type="protein sequence ID" value="ELQ74773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2302"/>
    <dbReference type="HOGENOM" id="CLU_909692_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTI4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978840" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35234" checksum="E7DD4AA50AD9D6F9" modified="2013-03-06" version="1">MKFLNFLLIIGSACLSEVTQNLALLNDHQSEIHDDAVVEVEWEYVYKDSYSVTALRKHIKDLNNKVNEIISCYNSLMIILLNFKETRQVKTAAIPYKCSKTSPKTSFTNDYNGSNEYIYTYNNTLNILSLLYQSGYKALSDVLLNITTRLRSLGGFTRIVLMLQSGGTQATEKLDLDMKKSQTLIFKFSAELLKASTEMDENSVDSQAKQRLYETKDMLRDWAFDFLKLSQEYFILNDPLAHAHESSVSAELILFTTKSNTNRDEKLVRKLPVNTNTSKNQFTIQKPNNTLKKKNRVYKPRKKQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTJ6</accession>
    <name>L7JTJ6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2734"/>
    <dbReference type="HOGENOM" id="CLU_554536_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTJ6"/>
    <dbReference type="OrthoDB" id="10600554at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979012" evidence="2">
        <location>
            <begin position="19"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="492" mass="57178" checksum="FC4482B17C02CC1B" modified="2013-03-06" version="1">MCVLWFAILLSLNATLNEQEFESEQFAGGVTHTKEFKEQDEEIAGAVTLMKEFKEQDEEIAGAVTLMKEFKEQDEEIAGVVTHIKEFKEEDEEIAGAVAHIKELKEEDEESDRYMCAQALMELDWKYVFDNDLLDDFDNKPLINLLQCSYTSYTMMKNVFIGYCNELQGNRKAFTKMLDCLEQDTQDVLVRRFNQQLQGPASGRYRVFLNDRESTKRRREWFSDDNPRGKTRKVTERIVTGKIISALAREETAIREKTYELVQKNLLIALMPVFMNEELTWTDVTMEMLFLRIERLVKLPLAWDELNKIMCTTVSAVLNSHFLKNALFGLNASNNFLEPGSVLSRFHFQVPKMNSTNRMPSRSSSTLQTRTVEEPDEQMMEIEPSFVKKTMFYTSHNVSYHSSEQDDNVALLKKECELKHSLTKLNLLECLMDRWHVVQTKTIDEFKEQIGMPSSNKPSHEHHERENKPKEETKESDEYNQAIDALASLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTK1</accession>
    <name>L7JTK1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74729.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTK1"/>
    <dbReference type="STRING" id="72359.L7JTK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2332"/>
    <dbReference type="HOGENOM" id="CLU_651457_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTK1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="422" mass="49851" checksum="F2B89A16A6F7FE2F" modified="2013-03-06" version="1" fragment="single">VLDEQLEVEARNDLERVKKEFEKFKKEQEKAERIKKMRDEYFYRKKVLFEDIKAISALQNMNEAGTLENSENLSNERHAVDLMRTFYERFRQILIERDGSMAEADDNHKRIVRELEALCKEENNLEYAIKANSNAIKNTKKSEFETSDLKAKMNELVALREEKTEMVNNVHRNMDEYMEQVRMSKRKNEIERYLSANTMIDDDMSREKISEDLKAFSLKKGCILTNRAAMLAVLVKMQHLLTDDLTSGDYKRITRENANELNEIFRVDYENADAADIKYEHVKDFFDGFKEYDSIEIPYNTLRELESAISSNKNAAHIYKDLKRLGEKRNACVLCNKPFVNNELNAYLAKLDYVIEKIPEKEREKTEEYKELLIKIENDEKRTCLLRNSTIYCEKLKILVRWITEMSVSVQSADIQRARVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTL7</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">THOM_2290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2290"/>
    <dbReference type="HOGENOM" id="CLU_2312987_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTL7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="102" mass="11344" checksum="88ED9ADEFB5D7BCD" modified="2013-03-06" version="1" fragment="single">LMYESVVDKAIAYLCGFKGVSWLNGYSPIESMEDVHIDALRKRLCSAIERENTALPLKRFAKILKRLAAVKRVEDAAMLHYQVASPSQQDIRPGVPDAPGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTZ2</accession>
    <name>L7JTZ2_TRAHO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1397221_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTZ2"/>
    <dbReference type="OMA" id="IGCHTKN"/>
    <dbReference type="OrthoDB" id="10299261at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="195" mass="23013" checksum="B37617F81911F3FA" modified="2013-03-06" version="1">MDVHVGKTIKILIGCHTKNMCAVKRSILTLLKLDRNEFTTVIKAVQNKLKEYEMRLIGITKNEIVPIENAEKFFITKYYNINEIKRRRISDLDENRGNDATVKSAGALLREYHAVFVIIFLESGIITLDRLLYFVRKLKFGANMEDVVYQMKRMHYLMFFKRDDIMVVTYDWRFNAEFPHYNPALALENFCTNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU67</accession>
    <name>L7JU67_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2097"/>
    <dbReference type="HOGENOM" id="CLU_2672862_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU67"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="75" mass="8627" checksum="F4E04C480B4D2D7C" modified="2013-03-06" version="1">MLYMSNKLKHENYQGYAWYAIVISLAQTSAISHEISGLMKKRTNHLHESTVIKTMVGAQRARRGRLGVWVVLRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU75</accession>
    <name>L7JU75_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.1.3</ecNumber>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.3" evidence="8"/>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JH994054">
        <property type="protein sequence ID" value="ELQ74292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU75"/>
    <dbReference type="STRING" id="72359.L7JU75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2798"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="L7JU75"/>
    <dbReference type="OMA" id="HVLNKMP"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="253"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="427" mass="49128" checksum="13EC3C470036AC15" modified="2013-03-06" version="1">MDQLKNEITEILNQNKITALTPIQALTVPYAIQKRNIIGISRTGTGKTLAYVLPALHRLLQHKKCNYVLVIVPTKDLVVQIVTLLRMFSPLGLKIASLIDRDEINDAHFIIGTPGALRKAVKKMKGVKVLVMDEVDKLFGKDYERDMRKILESLGLAVVETGDNLKETADDKQKLMKRKKSLKSADHKDNTRGIKENNVNTLKKTVQVMLFTATYDEALVRRYVDVTSFKVLEMKDRNEKVSQHYVFAPYKHRIYHLYELCTSISKCIIFVSRIFYTYLLSNLLKELNFNVCLINGRMPQKEKNAIIKSFKDNEYSIMITTDILSRGIDIPAVDNIINFDLPTSRKEYIHRVGRTARMSANGRAFSIVTQYDLGRLQRIEKMIGEKMIEYKIDENRMSINKDKVEAALEKVYKKSKLEMAEVNNRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUB3</accession>
    <name>L7JUB3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Rho GTPase-activating protein domain, Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1997"/>
    <dbReference type="HOGENOM" id="CLU_924976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUB3"/>
    <dbReference type="OrthoDB" id="2196166at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="101"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="301" mass="35529" checksum="B57209E285E462BE" modified="2013-03-06" version="1">MDIMNEGSCEMTRFVRRVIPGTGNPTRNLPGNDRIADHRFKSRFKVEHITFKNYQDKFIRYDDLSPVEKYELYRYAVFMLTSTVSANKLSFFKKIMKFGNNDKTEVCHIHPFIFKIMDFIKTKRANYHGIFRCSGDYRASTRLYERFIAGDVFDLNTTDVRNIVAFFKIYLKKKVNGIFSFDILDTLYETAKHRSSPSINYLLFYLPFCFVGDKRRFLIGLIDMFKEIDQHKNENDMPIPNLVRCIAPSLFPDTRLKSIETVFYQTWAVQKLFDIDLEKVPKPLLEFSHVYVVEKSSFSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUF4</accession>
    <name>L7JUF4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2034"/>
    <dbReference type="HOGENOM" id="CLU_056990_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUF4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="401" mass="46256" checksum="D8B780486862C9BE" modified="2013-03-06" version="1" fragment="single">VSHLHVLRKILTSLSTIETLILQDITLENSINLPDSIHTIVLEETSLSADSQLNFNTECSEVHFCNCIGTYNLSNIKRLLALSLIPSFDNGLKFNVRLPSLENLRQLDIAYNFNNECFNQNLSKCVDLEYLTVRSLYYSKTVTLYPSLSFVICDVLDFSGTNPWSKQKLSTFELGPMKFKSGSINVLNLKMNIFFNEIFTFNIRNKLKYLNLVGCDLDEENIEVLKELVNLQTLVIDCAFFECDLVKNIPNQLETLEIVDKKIFESQVLDLCSLDFKTVQELKKYENIKHLILDGSIIGYESIFDCLPINLESLKFTRFSTGKVNFPVKNRKKVVIKQLILLLDDPNDHPPVLIDNNPMRRQYYKLFDYLTNFIDFNKLDDLVLEASGKFVSLDKETYRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUK0</accession>
    <name>L7JUK0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ74995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2037"/>
    <dbReference type="HOGENOM" id="CLU_1171376_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUK0"/>
    <dbReference type="OMA" id="WNERFAY"/>
    <dbReference type="OrthoDB" id="2190614at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="213" mass="25654" checksum="4977E1B65F95EAEB" modified="2013-03-06" version="1">MPVETNLVYLLESSKYFDFDFLPEISTLLNLQLIKEGNIYTLSSQVFVIDIYDNTVTVLFVDEKWNERFAYLKQYFESCLRKRDFLLFFVLLRHFLRHEDPAKTYLLHNEYEYVRRVNAITLYRSRCGKNILFKHGLYFCECVFYSSTQITSLEHALDVNIFVHDDIVVPRNDCFEIKGNSFFYKGERDKKMSFLLKKGFMVEEIFDFFNIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUK6</accession>
    <name>L7JUK6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Exocyst complex, component Exoc1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUK6"/>
    <dbReference type="STRING" id="72359.L7JUK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1878"/>
    <dbReference type="HOGENOM" id="CLU_041566_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUK6"/>
    <dbReference type="OMA" id="IRECEYD"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="468" mass="56566" checksum="2C226BEFB576B11C" modified="2013-03-06" version="1" fragment="single">VQSKLEIDLYKLNRLSAELEDVQNMNNTYETEINNKEKLRDALSELVRMLEIDEKYFSYFENDNYGDAMVMSRIEESLYMFDCVLGCQKDDHRVYAYNLNDFNLKVANEFKKRILDVKKTFYKKFGHFFTKKLNSYKSKSKGELKIHKDIYDEVIKYKSFMTQEYVEIYIKCMKKLYSHEFRYHLESVFDILKRKKNVTLSVNLNVIFQSLLLIRECEYDFIRKISKKSTETHEQKNDEQSSEDETNSVYFATHFKDMDIFDDVVIMIQTFLADLYELDRFQTIIALGDSIQHYREKTKEELRSGFYERFLESVLNNYKNLRKDFVRLAISKYKGENKKKTIQFFNKVILSTKDDELREKMVHYHTKLVLKLSKDYKTDFQHVLRKFECVYPIRKCTDYYFLLVEEMKKIIIDEMFAVELDYVRIKKNVGYIMRMDDEEMRNAALKIFKGVVKDNTNDAEYRRIEPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUL3</accession>
    <name>L7JUL3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUL3"/>
    <dbReference type="STRING" id="72359.L7JUL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2636"/>
    <dbReference type="HOGENOM" id="CLU_718022_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUL3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="385" mass="44506" checksum="F0379D7F22BC7C5B" modified="2013-03-06" version="1">MISKKPPDGSKAEISEPSGRKFFLNKFFKEYEIFTVQNFIKFLSKGDNTESDADEPTVVEVVVDDNPYIAKIVLKNPNLWRKMGRIWSFHKFLGFATLPSSVSFHLDVKSFVLLRLSIFMVDLIVVHADIGETLTLPIYYTRHDGQFNNPTYEVHSNHNLNFTTKISLTVPRESPSFSILNLNTFEAWSDVSRFINGERRELVYRNKRRPELFYLLIPVGFRLILNLKHDLRIFIGLNSNLYFELSIGKFTYDGAVFFPICLDSAKKKGFDFSNIHQWRGDAAHPFNAYLVYGDMLLEGSSFGLNGNWNYFIPPIVDFLANPDSLTWIGSIFGWNIPHDETLEQHYTMDKILQMMNRCYLNGDADSTIVLRDNAYREQTLIPETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUL7</accession>
    <name>L7JUL7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MRG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUL7"/>
    <dbReference type="STRING" id="72359.L7JUL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2357"/>
    <dbReference type="HOGENOM" id="CLU_1005340_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUL7"/>
    <dbReference type="OMA" id="REICFEF"/>
    <dbReference type="OrthoDB" id="2193523at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="36161" checksum="496BBC2E6C1B8E8B" modified="2013-03-06" version="1">MSDQFHINNYVYKKINEEWLECRITNIQNNMYGLYVLKTLTNLNVAADDTQIFPSTIETIRKFKISMVRYTNGYLHMPAVLKAKIVGDYERVRSRGGGRESAVEENGGEDDIDLLIGGKEMNRNEDDERGGRGSVPKEKQTLKNELDSVKKAENTKKGAQDLDSRKSEEITSEQPTSVQETDSHNTSAELPDAKPNKSINSNIIEILDEFRSFMVVNKPMIYLEELDEFIKHVLLCFKILCYYTLFTAEEKRRYGKFDLEKKCNAYYLLRLLAYMHEVLMLDVEDAGAREICFEFYVYLVDFLFVNVREYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUN9</accession>
    <name>L7JUN9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1899"/>
    <dbReference type="HOGENOM" id="CLU_3360011_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUN9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4061" checksum="B639738D8B7E62ED" modified="2013-03-06" version="1">MNSNTCLHAVSAVLGISCALNDVLYDVLFIYQIWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUP0</accession>
    <name>L7JUP0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">5'-3' exonuclease HKE1/RAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUP0"/>
    <dbReference type="FunCoup" id="L7JUP0">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2015"/>
    <dbReference type="HOGENOM" id="CLU_006038_3_1_1"/>
    <dbReference type="InParanoid" id="L7JUP0"/>
    <dbReference type="OMA" id="ERWDHNV"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="606" mass="70923" checksum="247786DDFDF318E8" modified="2013-03-06" version="1">MGVPSLFRWLTKKYPQIIEKATPKNPTDILYIDFNAIIHISCTPSDGPTPVNEDEMMNNIEKNIDSIVSKCLPRKMIVISTDGVAPRAKLNQQRARRYRSIIEALELSKKSFENTKGANFVEKTKEKIQKLAKTPTIKDEYKVDFVGLMENSTSDEKTGVVDETNNEKKEEDNELEDVEIDGFEKHPSDLLEESSLTEDEAFDKNAITPGTRFMYDLEKRMDKFIRERLANNPMYKNLCFIYSNGRRAGEGEQKIMTLIRKMKNRNLKHTIYSPDADLIFLGTSLHGRNVKIMREDLEFVYLQRQHFCEKCGKKGHLSTYCNKLALFSCIFFDLIVLKRILSEELSMLITTSYEFNRMADDWILMSFLAGNDFLPTLQCFDVRFEAIEILTKLLAENFNRTKKYITYKGEIDFAVLKNFFRILAHYEDHLYIKKKKLLTDTRRRFQIKGFFENISLETTYGKTRYYDTKLHLKSEREVITVCREYILGLSWVFKYYVKGATNWEWFYPYDYAPFACDIANVRSMPYLNKRTEPLDCLQQQMLVMPPQSKGLVPKEMHPIFDSFPTEIKIDMFDKLLPWQGVAILPIIDMEIIVVPDKGEKNPHKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUR9</accession>
    <name>L7JUR9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferric reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUR9"/>
    <dbReference type="STRING" id="72359.L7JUR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2258"/>
    <dbReference type="HOGENOM" id="CLU_136954_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUR9"/>
    <dbReference type="OMA" id="MMMAGNI"/>
    <dbReference type="OrthoDB" id="2193718at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="149" mass="16884" checksum="6454070B99157576" modified="2013-03-06" version="1">MISYELFIPYVNSQGDHQKQLNMNIFDFLTPGMNERSESALIIIVIGSIFFLMGGMLFFDRVMMMAGNIVFSIGVLLLLMPQMSLNSSENLKSMSLFVAGIVLVFCGFAVLGFLFQLVSVLYTIRNKIPSFRSIVMNNITKILKFLRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUS4</accession>
    <name>L7JUS4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2547"/>
    <dbReference type="HOGENOM" id="CLU_3227281_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUS4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="4816" checksum="16CAD5180BFFF50D" modified="2013-03-06" version="1" fragment="single">VALRAAKLRTRAFLKWKASRTTIGELMNQSFKCSSATWITGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUU5</accession>
    <name>L7JUU5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993993">
        <property type="protein sequence ID" value="ELQ75090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1973"/>
    <dbReference type="HOGENOM" id="CLU_456485_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUU5"/>
    <dbReference type="OMA" id="ILECLMM"/>
    <dbReference type="OrthoDB" id="10440450at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="598" mass="69927" checksum="A770C4FB38076CE2" modified="2013-03-06" version="1">MRYRIRKSAAKVISSKKTKSFVTWTPMENERHFLVEVENKTSKLIDILPKVDDKISFINLYLYRNSHMKYDLEENKNVLTPYYDMLNVHSQVILYKFIERYPNGQCSDGYRSRDKVIEGERDEQAQTVKKNEENHKYRIENETRYEKNVFEHEKGIVEDVQECGASDTRILEKLGENSKNDHNINTNRAEVITCCTSSWDKNNDGMEKEAHNNTFDGVVSTKNCKLENETNEYVDTLSYLRDGSESNDEEMNKTEFPGLNIREMKKKLKNCVVNSVSSPECADVNKSTVNDDCAGVSSGYANFEEGLIKEYVLKSQNFHQKYILQIKNKTLIFKILFDHFIVYYRTNNEYAKYLLDKMIILISEYEIGMEESNLRALSVVMKDNNELTFVLGAFMSGREDLFNGLIMEKKYKNLFMKMKNRRDTTKRASTLNTITVADTVDPVSEVALPSKTHNFEILNIPTTLQQTLQEVQKGALPINFLLFHLNSANTRTIRNYMEQLFSVLLNNIFHPTVLKLLMMRTREYKTVIAHFFSFQSYGTQRVIILECLMMLVDDGWELSAEMIRMFFMTMDSTTLKFNEILEERIVAFYEKMKIMKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV19</accession>
    <name>L7JV19_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV19"/>
    <dbReference type="STRING" id="72359.L7JV19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2521"/>
    <dbReference type="HOGENOM" id="CLU_008247_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV19"/>
    <dbReference type="OMA" id="VECDFKY"/>
    <dbReference type="OrthoDB" id="10410783at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="896" mass="103249" checksum="0D85F6574F975909" modified="2013-03-06" version="1">MFMMCHQKEECLPKKVREASSAAAMIGFDRFIEDDEDFNPPDIPDELFEGYENEGSDFFVSMSKDEKVENSDQNSEEKSYRQSVVAVDDQKVEEDEIIEQQAEPEESNSREHQDDDWQLVYKQRESLKKDEQLDSRIDDEQISFDQAEDHAGLETPLNSEDKMKDHVFKEASFYNAKGESKKVITNNEIIDEVPNDLWSEEDDELAYTFEKLHIQGTAEGFMAEEMSNANKKATIFADQSQDLKRVSVSNEDKTVESDQINDSFARVYERGMHTSAEAFRSRMVNDVFSKIADKNAPPEEKALEDLIRKQRTIEDRIRVEDTIERLKNADNSKILHSEMDKPVNPFIPAIKNKPRSNFVPKVNISFSPHKKGVKLAFLKNKLLVITTVKQCRVNAVNEKIENVKYVERFYKIKSNQRVDAITKAEIKQKATNTTVRHNIYALLLDVGSFKRTGVRMSNDPGLNETMILSFKDKLAATMRCIEQKDYAMAFLLSKDNREAEQAAVDAYLQNFVDPLFHCFFCSTAENVRPYHTEPYPRDDGRWAEVLSLLLEKKNVNDHDMENLLKIKKARGEQFYVLVLLYLKFRKSFFHRYKDVLLTNYEFMRIMNYLKIKDVEDLKAYYEEYFMVTDKEVPVTSGGWGWKNYVEKGISKIIGIDSTFMENEAPKELSKRDENEQNKTVAESKSHSDENLSAKRKMDHQIKDGSESNTLLAKEALFEKHIKLAKENMERTEEKAVPDYASSFADFFVSEPLLVPDTSYDDQSLPKSVIDRDKDDESDVIIAKKEEKGWGFSLLNLFKRKEKRYKVKCNVECDFKYDPQTKRWVNTKAQATKAEKVDSKKDAAVPEKNVPLPCPVTRKAGTKKVGDSIASRYVIGNSAADGDEVNASDIFGVCKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV25</accession>
    <name>L7JV25_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1714"/>
    <dbReference type="HOGENOM" id="CLU_797368_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV25"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="348" mass="40883" checksum="0958521B3076E309" modified="2013-03-06" version="1">MNWDRVNSLLNAFKKLNRSLQVQELKAIECKQPEYKFVIAYFFKELKNKTSIALMNKFGVRDDGNRQEFELKIIEEIKRSGLLFRNIKNEFQYEFYDELINGPAGGVVLAMQFRCDDFDVIFDRLCECKVLEIQFMRNNLEHVIRKLLSGGVLNDFGLRICEELQGDIYQSIKEDINSGKYDSKENYHPFYSNERLKEAVDKRNDVNAYKLLCLRDVCDQYYILNRLFTFYEKGIIRNYGCILGYNIKIDLNIFEKFINANKLIGREIFVFLSNFTALVPADILRIVDIKMVGYLDPFLRKKCSILLPKGYYEIDLRTEQIFLDGMSDESGSKDTIIPEEGQVKRENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV52</accession>
    <name>L7JV52_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2172"/>
    <dbReference type="HOGENOM" id="CLU_111190_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV52"/>
    <dbReference type="OMA" id="CTTRTLI"/>
    <dbReference type="OrthoDB" id="2186354at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031513">
        <property type="entry name" value="MICSWaP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17018">
        <property type="entry name" value="MICSWaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978885" evidence="1">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="227" mass="26106" checksum="79F8647E42EB03D9" modified="2013-03-06" version="1">MLLLIYILLSYQATTLGNTQPNLPRRDIMTKVVRFHFYISPYARARYINENRKVEDLVQFVAAELERALNLYLEKSDRPVNITFVPIFVREIPPEIELDKCDTNMLELATTLNNFNLETSDTSIIAVLSCDSRPYEGVFITRGQEVPYITHSLSSQCTTRTLIFLEIEEHKFLAALSTAMIRAAGVDVLNPLLFEEVINGDAGVRYDIRVNNETMDKIKENMCFYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV71</accession>
    <name>L7JV71_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1917"/>
    <dbReference type="HOGENOM" id="CLU_2442430_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV71"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="90" mass="10446" checksum="829189F5D10EA3DD" modified="2013-03-06" version="1">MRTQNNLETLELFGFQLSESNANLLNEFVVLTKICVSYEMIDAKFLLSMFSNIRKLDIHRDLNMSDHFAENIVLCNEQCIKLLGELKCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVA0</accession>
    <name>L7JVA0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1606"/>
    <dbReference type="HOGENOM" id="CLU_2962542_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVA0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="59" mass="7370" checksum="6B7467E0D8D92405" modified="2013-03-06" version="1">MKVEHKNREKLEIVKQKRYTRYEDERVKFLIKNRDLLDGYELERIDENDRDFEVGKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVA1</accession>
    <name>L7JVA1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1843"/>
    <dbReference type="HOGENOM" id="CLU_1251456_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVA1"/>
    <dbReference type="OMA" id="TCEIATE"/>
    <dbReference type="OrthoDB" id="10331460at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="221" mass="25139" checksum="2964EBD62361F432" modified="2013-03-06" version="1">MITTHLHFYGSSRTERMFFVFINAIICSSSLSYGYKTIRSVSEPNLYITLRDGILRLKESHEPLIGMESNMVKFEGLGDGLRIIVNEKAICKAGENNDMVVACDIATNKNTEWTVTNKSGGEVIETDGFCLTKDELDTRMETRGYRLSVEKCSKASNYMWKISEVDPMIYNGNLGEDVHSFAMPTPYVNFLGDKSTKKLYRLIHPPFYRAKERPEDARGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVB5</accession>
    <name>L7JVB5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2396"/>
    <dbReference type="HOGENOM" id="CLU_2795743_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVB5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="68" mass="8103" checksum="5CE3EDA83B4B7474" modified="2013-03-06" version="1">MAIYEFIKNLVTFRKRKHESIQESKRARTENVSNGESVGKALNDLLIKKREKRNKQRCKNGEQRKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVE1</accession>
    <name>L7JVE1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor 2, beta subunit (EIF-2beta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVE1"/>
    <dbReference type="STRING" id="72359.L7JVE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1761"/>
    <dbReference type="HOGENOM" id="CLU_026663_3_2_1"/>
    <dbReference type="InParanoid" id="L7JVE1"/>
    <dbReference type="OMA" id="MHILKSN"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="2">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="174" mass="20082" checksum="B57B608F8560D519" modified="2013-03-06" version="1">MPNSSTEDSDSENSMPLGFDPQEFRKKREEKLKMVKSVLVKKKETEHVQNLPEELTYNNLLKRAMHILKSNDNTQAKMKLPLEVKREFGNKTTINLVEIAKILNRDPDHIKKYLFSELATSGSVNIEGKLLMKGNFLKAQIQDVLRLYIEHFIVCASCDAVLNTDIVRRINFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVE2</accession>
    <name>L7JVE2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial Fe/S cluster exporter, ABC superfamily</fullName>
            <ecNumber evidence="11">3.6.3.27</ecNumber>
            <ecNumber evidence="11">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.27" evidence="11"/>
    <dbReference type="EC" id="3.6.3.44" evidence="11"/>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVE2"/>
    <dbReference type="STRING" id="72359.L7JVE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2384"/>
    <dbReference type="HOGENOM" id="CLU_379063_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVE2"/>
    <dbReference type="OMA" id="RDRTGDH"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="12"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="401"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="731" mass="84269" checksum="278EE028322F8C13" modified="2013-03-06" version="1">MNIHLYIFKRYVILNTTLALFMPPILTCIILSKYLKIYASSILKDIGQAIEDSHTVSRLIIKLGACYLLYAFFNEIYDFIAASPIQRAARHASNDFLRNCLMERVRLYECSSGEVGRTLVRSASAVSDLIDITLLEILPLLITFVLALTEMYRKFGYAAFMYNVMMLIVYIVITFAITRYRMRYRRRNNMYENRAHSKCLECIRNVDTITVYKTVQFELNQYDDINKKVQFYSSRQYQSLALLNLTQKVILYIFMVTYLYRVRESLGNDQLLQYFSICSTIIEELSNLGCIYHRFSKAIVDLNTPFVRDMAETNQTYDRKPSVNLTEEPRTKRNTHVGNAVDQYHARGHEETNNDGRNSNNYAQKGKNICREENINTDQESKNDIQENGRAIPFINTKPLLQFQNVTIKHKNTPILTNLTFNVAQYAKVAIVGPNGAGKSSIIKAILKLTPYSGQIQKIENTRLTYTSQEPQLFADTVLYNVAYGSKAKLRCIIAIAMKMGVHKDILRMRGYGSLLTENARNLSGGERQKITLLRNVVYGICACGDGVDCAHCEGCRDGSVQEWSDEEERNVKISVADRESITQFNDDHQAFNSDFVPYEVTMQDDTYQNATEDRGSTTNYNMMYDVDEISSKNEETFYPSAKNSPSILMLFDEATSAMDKSSEYDVIERLFDVCSECTVLMVIHNLTILHLFDTIIYVDKELEIGSFDRLMQKKGNFYLFYERMRKERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVF3</accession>
    <name>L7JVF3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1777"/>
    <dbReference type="HOGENOM" id="CLU_641236_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVF3"/>
    <dbReference type="OMA" id="IFQGHWN"/>
    <dbReference type="OrthoDB" id="2192271at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="428" mass="50224" checksum="19531573BDC40742" modified="2013-03-06" version="1">MLKDLHDLFAKSKNILEINHETEEIKNKIEKLKNSRKSSEDAILCQLKQYEGRLVEVERLLHDIHPNVQFAIFKNKNNEVLYRIEKDAVASAENEDENELRTKFKVFKRYNNLITYEDGTYFYFLLENENMKGNQADVINTENLSKSKGVFRIKSKFSRTLYNVLLSNAKKEMKNLSEELSRFNEYFVDTPFYKKNIDELKKKVLVTEVVKISKRSKRTEMVNLGAIISTDLKDFLDALMIMENLINIDDIKIMKFVKQAIADFFDDKRSKTMHEKILAFSDAIYFTQQYKRDFYDANGLKEDVFSNIVKSEVVSFQQSNLEHFLNDLKRDILVFNEAVDEIFQGHWNDTLKEIYNDKLCESFVGYVLSFDTISEFDALNLTKISKFLVKQGVSKLANLDALFISRKKNNLRIDDDEADMIIQKLSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVG2</accession>
    <name>L7JVG2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2358"/>
    <dbReference type="HOGENOM" id="CLU_1300523_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVG2"/>
    <dbReference type="OMA" id="RMALRTC"/>
    <dbReference type="OrthoDB" id="10376535at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="212" mass="24845" checksum="570BC047F57B48B8" modified="2013-03-06" version="1">MKTKRLLKFIGLFSISFLVCTFFISYVIYKCHNDSLSRKVLRFNNKLSAKHPIARSEVLCIMSPEGEHHYVYYTEKGEFYENIVDRIIDGTHILKVVDLDGCTLNARYTQDVLERYGLCPICRIATVFVRTGVSVGYDRMIRFLRGLRLSADMAVFFFVDDYDVVIRVIADRKEIKRCVVRIGTYRGSRMALRTCLYLFHRCINLDREYLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVG6</accession>
    <name>L7JVG6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2363"/>
    <dbReference type="HOGENOM" id="CLU_1570637_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVG6"/>
    <dbReference type="OMA" id="MNQIDIY"/>
    <dbReference type="OrthoDB" id="2187412at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="197" mass="23517" checksum="0DD95CF2695656CF" modified="2013-03-06" version="1">MYKSSLFLFYPLVIMMSIRNKLKATCEHFLADIHSFRMPIKNETTLTKILLATHITFTKLMNQIDIYNRHIHVKTIKLQKKERKDLFTSYEYNNRDVTFTVLTHDEHGIVQIETGLIELNYKAMNYVNKLEIKDQLEQIELFLSLYADFKWRCCDFCLEYTIFPDFNFPIGRALEKDFVAAFHLECNEKSDEKHKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVR8</accession>
    <name>L7JVR8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2237"/>
    <dbReference type="HOGENOM" id="CLU_975071_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVR8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="286" mass="31921" checksum="30FDB1A36BB360C0" modified="2013-03-06" version="1" fragment="single">VHTMLIPYIAVGTLFALIFGWRNRNTIKSWLGFGQNSHEMMTHGYDSASKVFPADASTLSDQSPQVSKVGDQYDSVDNQREIKTPDDSHCREIRQRTRRGGGIFEERKLQDSGIPEEDQNSINESENEGKKPWSYRDAAREFLRNISLTGASSTSRKKGTNEDVKHQDDTLPMVEKTDGGIKSSHTEENVPSETIRGEIEETQEVKEEENGSTTAVSSQDSINPVTDLTSKLALTPSSSVADITESHTNSEDHKRQSDSLSDSAENIGPEVAPNNGERRRHRHRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVU0</accession>
    <name>L7JVU0_TRAHO</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993944">
        <property type="protein sequence ID" value="ELQ75544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1502"/>
    <dbReference type="HOGENOM" id="CLU_2943460_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVU0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="7167" checksum="BF8B9265E5E20C15" modified="2013-03-06" version="1">MGLNIEQEMRILTILNNKESLMNEQIFITTIVQLASCLFINIDSNVKYFYKYNTRKSVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVY5</accession>
    <name>L7JVY5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small nuclear ribonucleoprotein SMD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVY5"/>
    <dbReference type="FunCoup" id="L7JVY5">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2163"/>
    <dbReference type="HOGENOM" id="CLU_2470665_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVY5"/>
    <dbReference type="OMA" id="GVEKRKC"/>
    <dbReference type="OrthoDB" id="2190807at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="88" mass="10449" checksum="3F77F553EB42E9E1" modified="2013-03-06" version="1">MQIIQFLRTLKTKRLTIETKEKTIIKGTLTKIDKKMNIYLTNATIHNEPVDSYFIRGTQVRYVIVEESEVFGGVEKRKCVDEERKRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW02</accession>
    <name>L7JW02_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW02"/>
    <dbReference type="STRING" id="72359.L7JW02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2126"/>
    <dbReference type="HOGENOM" id="CLU_481110_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW02"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="287"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="567" mass="65868" checksum="DFB6D7105B2E1F4C" modified="2013-03-06" version="1" fragment="single">VYVNQKNADVIRSAINFLLITIDDAFDLQLLYVILKIYKILKIHEQVIDELLERAIRHVDYNTGIYAELAQLTDGFYRFYFFSAFNCVSADTVEPVLCLKGVPVNKRAFVYNTFYLADNAEDEWGDALIYRGYVLECSESIDVFTRIRAFDGDINDCLAGIRRIHPFYVPQLVQLLRVERCFDAVARKILELVRNDDYLSMLVYFNVRANFRGSERIGGLLEKICTNFKDTVRFVDDMTEISLKMMKYRHLDRFDKKKMLDELLNEVVIGRNVVLPLHGCRVLGILRNSSRVLQSHAKVPFMATFIVERNGVRTNADLIFKAGDDCRQDQLALQLIQMFLNIFKESNLPIFVYPYTVISTDYECGLIEVITDAISRDQMGREKINNLSEYFSLKFGFKEGTAYKKAHRRFILSFVGYSLVTYFLNVKDRHNGNIMINGRGEMIHIDFGFMFDISPGGLNLEVPLKITQEIVELLDDHMDEYVSLMIQGFFALRRRSKDIVLMAASFENSQLPCFTENAIDNLIARFKFHLSDAELKVYIRTMIYTSVRKFRTYIYDKFQALTNDISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW03</accession>
    <name>L7JW03_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adaptor complexes medium subunit family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1420"/>
    <dbReference type="HOGENOM" id="CLU_1932686_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW03"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="131" mass="15295" checksum="0F125F9F38173ECE" modified="2013-03-06" version="1" fragment="single">VQMPLTLIKNEKNHYVLRSCLSDRSSITIKFPISKKAYNTVADSDIGHIKIMDEHIEWIIKNEQFKEAEIKYDFDLLMSDNEKLGPIQISFTSKFFSLSELIIKDVRDSDNVKKEAWVSYMVEAQDYEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW20</accession>
    <name>L7JW20_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994004">
        <property type="protein sequence ID" value="ELQ74957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2106"/>
    <dbReference type="HOGENOM" id="CLU_043368_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW20"/>
    <dbReference type="OMA" id="PRIMAVY"/>
    <dbReference type="OrthoDB" id="10447513at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="352" mass="40838" checksum="21F6A9AA8F46713A" modified="2013-03-06" version="1">MLVNLEEMLRDKNIFVIITFFGLVISPSYADSFFRTCRQSISQCSDTNDEIMRHNNAVLCKKHLYLFGQHVESFSAIVLAFRKDFPYYFVQRSLKKQGFDGSDISKQSFIREIMCLLYLLYERVEQKIVEKVNCYNVLFSNTYDNTSTSMLYAELVKVYTNFMDAFVLFTPASSILQCEFELPRIMAVYFSVQLLSEFDLRPNNGLDAIFVKNIADYETSNGNKDIKAIEISANQQFFNVYQSKDHKKNIHVVLPVLLLYFDAVHLVLNDYLVNFESLLLLKNIIDNGNVTRLTASIFDLHRFSFYTFVKKIPKCKKTVLVLNLSGCFLGDSDLQAISDFNNLKRLVLPKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW55</accession>
    <name>L7JW55_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase III subunit C3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1488"/>
    <dbReference type="HOGENOM" id="CLU_794997_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW55"/>
    <dbReference type="OMA" id="MIPRTAD"/>
    <dbReference type="OrthoDB" id="2190900at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="44086" checksum="E91B7CE2DC9AD211" modified="2013-03-06" version="1">MLSTRHFSSRGQNIFYRKLRLSSVTNHPLVMYKIYKFLLNERGTLLEPVVDFMLNLKTVTYKQLICNIPLDSVTLTKILKYLIQTRVVEYNIYQNITYYTINTRYILNRLFLPLYMGILSEKEQKVLLELFMKGVTVRKNDDVDAMLFVKSVSLNEVKSLLRLNFSESCVKEEKIKNVGITKRKKTKKYLIINFDYLEKKLLNRIVNDYMLERYIELGNKNILKYVENDRITQCKHDHSEKSVICTINNKNLIINTMVLKQWIVNRYLDLDSRKLYNFIAEKLFVPDDQIIKQVLIERQKIKPILFGLMQNGLIAIHKNGWVNRMSFGGVACALATSMELYLARAAKTSKESPDNISLISNIINISEDLFVLKCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWB2</accession>
    <name>L7JWB2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1281"/>
    <dbReference type="HOGENOM" id="CLU_1541192_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWB2"/>
    <dbReference type="OMA" id="ISYCHAK"/>
    <dbReference type="OrthoDB" id="2188105at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="174" mass="20365" checksum="51661759103E820A" modified="2013-03-06" version="1">MLLLKRSLRPLNIILLAKLKKLPSMPIIIVCGDDEYVKQFCDDYTNICSDKNVVVHNTAFSEAISDVIEDDPSFFHIITRSYSKSERYISYCHAKRFKTGYIVVFLRGACINVDLEVPLESNRYDNPLITVNDYKNDIFDNINNVLCNTKMKKFKIKRKNHNKRKLHKRSKEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWG9</accession>
    <name>L7JWG9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Ricin B-related lectin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1643"/>
    <dbReference type="HOGENOM" id="CLU_421611_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWG9"/>
    <dbReference type="OMA" id="IHDIEFC"/>
    <dbReference type="OrthoDB" id="10505411at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978856" evidence="2">
        <location>
            <begin position="17"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="650" mass="73582" checksum="F8F1ABF2EA13F2A5" modified="2013-03-06" version="1">MLFTLMFLRIFINTLPIDSFGWIKLHHYNSNQYLVEDNGTIKLKDIDVEDVEPFRFIQDGNGFKIMANGRFLCMEKHFGDIHLCTDEHAVRWKIYREGEKNYIKNDYDGCLKVSKRNENDHNIKVRRCYDNSMFHWDIINAHGMDIHRDHSYVSNVDSHRPDEPVLPVRVEYSAPLPVVNLFTEDEGIGNESFGAKNKKINSVNHEGRLDAHQTNHSVDMEESENDKSDADDDDELEVKPKKVKIDYPMNTHHVVETHSLINEPAFHEESDTLKTTSTPNRIGVQTESVIKEPHKATNTIAIPDDEYILKGTETVPTSKVTENNLLVVKQPVSEGIDSGSTSNSPTDVRPVSRTGIQIEPSTSDQDITLNTISIPDKDRHVLENIEKVPVSGKTPNNLSTSKQLTFTKKAEEIPAVSSINSIKKQKAPLHAVNEDGVLLHHNPSRKYIPIRHVEENSAVEEPTKQKLNTGRRSKDKIAPYTSNQDKSKRPSRSQSGKTSTNKTSEDNYKDESDSLMEQVEEWLGGSPTSKKIPANFSGTDTASNRSDMKELESFIKRNDVLFENASNSDDFNIDANIVAKQSDKFKENWKNAFKTCNGLFCNEDDYENIDIADILAGDYDDKIAQISNIPLYVCGLGQKNHPAIHDIEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWL1</accession>
    <name>L7JWL1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993987">
        <property type="protein sequence ID" value="ELQ75132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1933"/>
    <dbReference type="HOGENOM" id="CLU_577704_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWL1"/>
    <dbReference type="OrthoDB" id="10478927at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="473" mass="55211" checksum="9F88ED372FE7814A" modified="2013-03-06" version="1" fragment="single">MVDLIQNREKHVLYRRLKIWMNEHFWECGDGIDLLREDVMYEDEGFIGMFSAIGLNEDAELGKDRNVVREMEGITEQDRETILNRNMNSSEKSAAPNKCYRSKSNQPMQYTAPSRERGVALFNLYAMEQCCYETCTSTKEPFFRWYANNNSFFTPKEKMILLGQVRGLSVLNNLLYEITFKRLSAGECFVRSVEVFRKMNVPFNGVVNVLRMDCRFRCNEGEGNGYEEKIRHVECRGSRDYAKVFRKAVNSNNTSTRAAVDHKNVLPFSFASRTLSDILNARNTPYLTNNHILNLLILYLSDKEQFNTYINSLITRTKDWQDILSLLNISSFSVVSYLNRLPIDALPRILEMTSQSNYVLQFYVNTMTSNEQIFELLCMYENAVTVKGSFIRWVINKEYKRIKNCSLVHFIQLYNTMSATTCNRDLLFVLKYKLLDGDELVFELLEKMKDWQLSNEVLLKAIGHIIRIDDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWS9</accession>
    <name>L7JWS9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1105"/>
    <dbReference type="HOGENOM" id="CLU_043487_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWS9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="491" mass="57310" checksum="3E5972DF8ACB2040" modified="2013-03-06" version="1" fragment="single">VNLEFHRKTTTPLPCSSRVDRFHRIIISENVIQEYISRLSEDEGYSDMLSLFGIVLKYIRFITWSKEFAKSLSYFCNDTNLILAILNIFMDIHVAWDYVDLQFMSNNRLNRIEFVGVTFSSDNIFIHLREFVHLESVIFYQCNFLKQRLLCYSGNTQCEVMTSFKKHLDTIGTLNALSFEWSKHLIENNSIVNLKLCLKSSLNFQLLRLFKKLRYLSVSFEQTIFNGNGNLHSIENQHFALINCAAGVATLKKLLVKGLLVTVKTNQAMNELRLVKCVQLCSPTLYESSNIFTRANSWVEKLRTLSFRIEDLDKIFLLARYNQLSNLKEIIIEDCYDLINVNLPIIKNLDEQQIDTLVIIRAYNPVLITFIESLKSLKTLKLEDPSDSAVIEILNLDAIKHRVERLVIMDTCLDNTTLEKITMFECLKHLTLRYIKFIPNLDIEVLLKFKRKITLKIVTSRLDVSDFYAIKKYRTIKDFQCYDNEEGYIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWX8</accession>
    <name>L7JWX8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1266"/>
    <dbReference type="HOGENOM" id="CLU_1267683_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWX8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="218" mass="24749" checksum="71CE261E1F5E8B65" modified="2013-03-06" version="1">MDCGITNGENLDCDVGAAFEPQEVKNRATIYNLSEFEVSCWMNDHTPGKFTCVSEPIVQRDDSKYMGNWKIGCTKDNQEESAICTIGSNNARSRTVKLMKMGLQCDELNNNPITCFSDVTLERFDNNDKAANISMILEKAQAFTDNIHIPVTTDPVLASKNFDRVLAIFKQMQVPTNTNTMILTCIMPLFVIVVILTSIFWYFKKRSRPGIRQNNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX12</accession>
    <name>L7JX12_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.57" evidence="9"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX12"/>
    <dbReference type="SMR" id="L7JX12"/>
    <dbReference type="STRING" id="72359.L7JX12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1011"/>
    <dbReference type="HOGENOM" id="CLU_011001_2_0_1"/>
    <dbReference type="InParanoid" id="L7JX12"/>
    <dbReference type="OMA" id="NAAAWMY"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="314"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="520"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="757" mass="87011" checksum="23D42B1D1C4F0C52" modified="2013-03-06" version="1">MSELICKDKVGVFVGVSLTISSDRASIKVFVTMNDGNFCIDTQELTFKIININDRECLRNIIEIEERESVEGVGRFSVSVDGLITIPEPLVCDHEFQPETDEPTHGVKMLINYLRSIGNYYQDEKFFYRICRKCDRLEHLNKSANTLVSESLNQDFELEIMRYDDTNYRMLCMVLKHVNKAVKNFLLEYTTRNNMKIIAGGFPASTFKYPELLMAIQHEFWIDLDAFPCFFLTTRLDIESIADSFSRKSARLMGFNNLLRLEISKHNVVEIDSSVISFCSLQSYRDFLENPLLRVVDDLQVIAKRFAGKRISFISSTPQGGGVALMRHAHMRFYKLLGMDVSWYVTIPVASVYTITKKKFHNVLQNVARNEQLCAEDKKIYESWIKINCDRLWSNSVFKESDIVVLDDHQTCGFYKFVRSANPKAKVIYRSHIQIRGELYKTKEEFTTTWNYIFSNIRGVDLFISHPIESFVPLNVDRRKIVYQPPSTDPLDGLNKPMNEYISDYYECLFHKSSGECQQKELSLHKPYIVQISRFDPSKGQKDAIDVFSIVYKQLESRIKTVGDPLYDLHLVLCGHGSVDDPEGGLIFNELMAYLDEEKNAAVKNNIIVVKLPPLDQILNLVLKKARVALQLSISEGFEIKVTEAILKSVPVVVYDSGGLPLQVYEDKTGFIVPCGDTAAAAEKTTYLLEHPEFATNMCGYIHLSYIHTTPFQILGWTRIFEKVLKNEDGNEEIILESIVKEYFDPFKDFMLPKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX17</accession>
    <name>L7JX17_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAH-box RNA helicase</fullName>
            <ecNumber evidence="8">3.6.1.15</ecNumber>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.1.15" evidence="8"/>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX17"/>
    <dbReference type="STRING" id="72359.L7JX17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1016"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="L7JX17"/>
    <dbReference type="OMA" id="YKMRFNK"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2130">
        <property type="entry name" value="DEAH helicase family, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042035">
        <property type="entry name" value="DEAH_win-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="216"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="675" mass="77365" checksum="05E18917AD225FEC" modified="2013-03-06" version="1">MDAYDDLIYNKILTNKYLLITAPTGTGKSTHIPALISTRFPTYTVAIIQPRRLAVLNIYAYLKHRIHGLSYRIKHSRKEHKHGKITLMTDGMFIKDIMSGREYDMVIVDEVHERSVRIEFVLMWLKTVRLKKAIFMSATVDDCDVERYFGCERVDLRIRGFRAHVFYEEEAVSDYLIAAYYKIKSILTGTDEHSKGGYLASKRKLKTKLTDGSCTNKSKDTTHIKDILVFLSGEEDISELRTMLKRLGVDAVAVHSSTNYEHITTSNQKGIKDDNNVEKGGSAAEPPTRVILATNIAETSVTIPNVKYVIDTGVHKTKIFKNVNFMGVQRISKESADQRKGRCNRLTDGICYRLYTENAYNSMTKMVPEIMRCDLSDIILWMCAMEMDVLKWPFLVYPRRENVKRAIEFLTEIGAVRVTRQDRKEDGDKENELRSAHENQNKIGSVRKGGNKKGLSSDRGHENTSRFMVKITTYGLKLITYPLDAKLSNFMHISNDLSCGKLSAKIVSLINEENCNFLVNPQKYDILSLLDLMNAFLHENDSGVYNQYLKKHSTVPDPYGDMLIDGTEHTFDKEKFCKENKLNIRALERCVLTNNQLQKNAKGTLVQNVEKAFSRSFQHNLSVLQKDGSYKMRSGQCVYVHPSSYFFNKRVKKIVFVDVLCTSKFYVRVVGRYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX98</accession>
    <name>L7JX98_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1669"/>
    <dbReference type="HOGENOM" id="CLU_2251924_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX98"/>
    <dbReference type="OMA" id="KYACSAH"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="104" mass="10816" checksum="1490BFF488B2840E" modified="2013-03-06" version="1">MSLLFWIIIIATVAAILLVGVPLLVHFMGKKDNSPSKDGEGNGEKGGMKSLFGGGGSKDDSKPPKDPAKDDMNKCEKDDKKGMKEGPPPGGNDVPPQQGGVPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXC6</accession>
    <name>L7JXC6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993965">
        <property type="protein sequence ID" value="ELQ75402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1644"/>
    <dbReference type="HOGENOM" id="CLU_1696837_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXC6"/>
    <dbReference type="OMA" id="NINKACS"/>
    <dbReference type="OrthoDB" id="10401986at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="177" mass="20904" checksum="30CD0EA15D3FE030" modified="2013-03-06" version="1">MDKIIEAQKLNGKSLHAIEPHLQKITAEKSQKLAIWLADCSYDEVDANSMLRFIKTYMRSAHPVFIVEIYQYLQKKDKTLLREYVERFKQMDTCDKGTDRKIKRVEKKKMVDKTDKRIKREAIKRANKCVRQQRDERIETKEKLKIFTAMCRNINKACSITFNSILLRSSCAKAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXD2</accession>
    <name>L7JXD2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993894">
        <property type="protein sequence ID" value="ELQ75975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1061"/>
    <dbReference type="HOGENOM" id="CLU_425902_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXD2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979104" description="Secreted protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="72610" checksum="9E3DB8811E3FF6B8" modified="2013-03-06" version="1">MVSFIRNRSNATNLLVQLSSLLVFLGCTQAADRREEVPLGTGWTPSLSFEERGIAQPQQQYQSFGRTHPGFTFETIVPTAPAYTQRPNMSMPPQSIRPQARSTTQPCDARRAPVGKVHSQFAYSEELPPRQYAAQPVPQNPKSQQQTLERATEPKAPQVFLLQPTEAAGIGILNPEHRLNVVSQQQDFIETSSNQFPRTMPESRSQYDHQQPLIDFSDESAFQSRPKLVRSDYLEQASCQQELTPEEAAEAGLKSMEDILQRAMHMRNFILGKQYEVYQMKKLVDILYYGSVAEKLEADATYLQILHHYFAIKESCGFYVPEQAKEDLIHMIRLNIQATNRVDEYKKHLKLTSAQEDRDDNSAFVGDDKIDISYSEELMKDFRRSMDQFNFYATDCVFKEILCDFARESSCAIQGLRTDIVNFIKNGDVPLVDVPVPTESVDDAAKTTCQSAETHGIQANTTPFQQIYDMTEVFVDKVFKILNERTLIPPEACDSDAQVRIPHFNVQPFVPRTKNDARNATLPSSASKAQPTGTAKRNVRFGMRATPSQVYEDVMQALSSFGPSRTQSEAQQRPPTAEKSVPTRMVQQEMYGRQPEFSSSSKSKGNRVGSGSFSSVKYAYERAAEEKKTEGKHKSNSGMRSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXD3</accession>
    <name>L7JXD3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0889"/>
    <dbReference type="HOGENOM" id="CLU_891940_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXD3"/>
    <dbReference type="OMA" id="HRFDYYK"/>
    <dbReference type="OrthoDB" id="2196297at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="312" mass="36142" checksum="A6CCEBE01F81DD7A" modified="2013-03-06" version="1">MKIIYNQPLDLAYSTEIVIEQPKRKKRRSTTDTYDYDDPLIEHMENEDAPVSIEADLRNFFVYSGKLRETSAQTLKKYELRLRRKAMKDQMSRSGEEAVNSTANIAFAEQFTEKVLKFYLDERKRVLGEMGEYFKDRGSAGNENEGRGVGAEGVSNEALKSVINIDGLIEEYVLLEATYTNKSFYDISHDIVSLNGPSLSTDLLIKINQKMAEAIKMLTVTLNAKINELSSTKKYDKNVVFSICDLMDKKIRNYYLGLLIRPEPRRSYRRVRRDIFVEIFGGFVGGDFDHLKKLVHRFDYYKEKRKLLVKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXE9</accession>
    <name>L7JXE9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JH993869">
        <property type="protein sequence ID" value="ELQ76143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXE9"/>
    <dbReference type="STRING" id="72359.L7JXE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0877"/>
    <dbReference type="HOGENOM" id="CLU_007683_2_0_1"/>
    <dbReference type="InParanoid" id="L7JXE9"/>
    <dbReference type="OMA" id="HNIASII"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="8">
        <location>
            <begin position="72"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="466" mass="52338" checksum="096F401D3A11EFCA" modified="2013-03-06" version="1">MPILFSSILSTPYPSMFCQHPVKLNKLCALCGQEVQDSDNTKFYNALHSNSRLMVDKETIDSMYVRYRDELIKQRKMILVVDLDQTILHSIEIERSNDGNNRSNGSIDEGYKTTNANSKSSSDGTNNADDNNNITTNTVPTTAGPTTNISSVYNINESSNQRTSTDNSFPSSFTYTLSSTTMHTTLRPHLHQFLTEASKLFHMHIYTMGTAEYVHQITNVIDKDGMFFGDRIVTRDDEMQVKRLERLFGDKVDMVVIVDDRGDVWEYCGNLVMVRPFLGIDGDRAVDDSSRNGTENGAVDIIFDAGTDGVNINAVNINSINTDPSNITSPKVDPSNPPNITPHKNDNELLILLHTLQSIHHKFYATPNQSAKAIITSLNTQIFKNKTFAMDHSMPDIHNIASIIRMHGGTFGNDGCDIVVGDDAVVRWVMECVWRRRWIDCGGLVRKIGGWWDEVDEWVDELEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXJ4</accession>
    <name>L7JXJ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993954">
        <property type="protein sequence ID" value="ELQ75477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1581"/>
    <dbReference type="HOGENOM" id="CLU_1032719_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXJ4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="270" mass="31075" checksum="15695B772A5DC54E" modified="2013-03-06" version="1" fragment="single">VKISGDSILLIIEKCISIRVVNCTSSINIPKVLNEEDDLLVGLNVATRFYFIKQQNGKYYMRMYNVEIKETTVPNKKVEVVVLENIKSRNGAVILFDKSTNQFIMSNCDFPVHQQALGVNNNIVRFWTSNVCYRLLNGHIFRANKFSAKICRLSQTATRLIINGCQIDSGYKFGIDSCCKYVYITGYRSTFVLFRSLSEETINVQFNGDSRFIFIKKRFCQDYIMQLYECILKSTRKIEINVKHLILKDVAISNESNQGTTGNLQWSNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXK5</accession>
    <name>L7JXK5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH993869">
        <property type="protein sequence ID" value="ELQ76149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXK5"/>
    <dbReference type="FunCoup" id="L7JXK5">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0883"/>
    <dbReference type="HOGENOM" id="CLU_032917_2_0_1"/>
    <dbReference type="InParanoid" id="L7JXK5"/>
    <dbReference type="OMA" id="CTEIISV"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="359" mass="41752" checksum="2337936234D82629" modified="2013-03-06" version="1">MSSNQLNIVLESTSSLRSRLKDFFGWFCAYLIESQDTGANEPIKMVSRDSTKNSSHTTALTGNNDGKYQLEDHKDDIFKFHKMSPEQIKRFIDAYTSFYNDHAPTYTIIDKLFLRTPSRIKERHAHLAALRALNIQNIKRRDRYAFLPIWQCTEIISVLLSALSLLNTIIMYHTRIQGRLTPLHNLYTMQYRISCITWISSILLHIDDNRITRFCDYFSALLGIMYYFYTVIVRLLLSFKVSNIKEVTTHIFNALTLVYISVVYHNITNFNSRALKFVSGVFIILFLVAIVVQSIFFPNKFIKYIVVLTIIGVTVESSDIEPFCFVLDSHAMWHFVIGIQNFYYNRYLAEEITLMGGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXM5</accession>
    <name>L7JXM5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-directed DNA polymerase, LTR Retrotransposon</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JH993878">
        <property type="protein sequence ID" value="ELQ76075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXM5"/>
    <dbReference type="STRING" id="72359.L7JXM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0951"/>
    <dbReference type="HOGENOM" id="CLU_1846502_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXM5"/>
    <dbReference type="OrthoDB" id="2195352at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="139" mass="16248" checksum="A2CF5B50DDB697CE" modified="2013-03-06" version="1">MEEIPDVVTRMLRAFNVEDSNKSGDALKIDMRHKIDLIDERKYAYSKPYQTSLKEAQIIKSEVYKLLELEIIRESKSQHLSPVLLVVKKDGTTRFCVDYRKLNLNTIKQPYPIPNMEQLMKSIVHSNCYSTLNLRSGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXW2</accession>
    <name>L7JXW2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase with different specificities</fullName>
            <ecNumber evidence="4">1.1.1.100</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
            <ecNumber evidence="4">1.3.1.77</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="4"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="EC" id="1.3.1.77" evidence="4"/>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXW2"/>
    <dbReference type="FunCoup" id="L7JXW2">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0764"/>
    <dbReference type="HOGENOM" id="CLU_897719_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXW2"/>
    <dbReference type="OMA" id="NACQFEM"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033729">
        <property type="term" value="F:anthocyanidin reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="295" mass="34182" checksum="1367383D9FB467EB" modified="2013-03-06" version="1">MINKLIYSISQRKYVPFIVKLVIVTFLSYLFNIVHFYRMRSVEPKKVKHKFCVITGGTRGIGRELVDLLVLKGYEVMVLGRTKVNRSKVVHYGLDLNNLQEVAQFKMDKDIDLLVMNAGILTGKTDGIDLNFKINYLAHYILYNNLRSNLKNARVVLTSSCVMLSVDTFDPYRPSFFSFRKYCESKLCVFLLGKYISRNLQTVVVHPGVVNTTLFNENSLLNFFISKISYPFLNSTDEAANVLMNACQFEMSREKKIIFLYGFEEMKIPCSINRKNEKKLMKITKHFLVKNGIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXW9</accession>
    <name>L7JXW9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LRR containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993856">
        <property type="protein sequence ID" value="ELQ76308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0709"/>
    <dbReference type="HOGENOM" id="CLU_1158822_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXW9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27629" checksum="EFAC3997AD774516" modified="2013-03-06" version="1" fragment="single">VRCRAEASAKKNEISDGTTTCKTIGVYIGRCINLKSLSIKISDDIIVYHNSTNLSNLKKFSYHGDIMYSWLYSNLLVHAQLEHLFITASGSKVYCGIELLRLINTQNLQQLVLRDYNMNAVIWNLYDIMKLKLDALVTLKIKTLFYGTYDIPNNDLHLVMRTMPNLRLLEIECSSIGSNLAEWIRNLKSLQALHLTMYCSLDSVEFFDVNGDLSKSLEQYFVNYEININELIRLVRTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY22</accession>
    <name>L7JY22_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_0705</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY22"/>
    <dbReference type="STRING" id="72359.L7JY22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0705"/>
    <dbReference type="HOGENOM" id="CLU_024513_2_1_1"/>
    <dbReference type="InParanoid" id="L7JY22"/>
    <dbReference type="OMA" id="SKECLWY"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ76329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="187" mass="22339" checksum="FEC37684D81EF7A6" modified="2013-03-06" version="1">MQKKEPVFDFENFIETNLKLKEKDDIYCKPFQKSQCFNPRCQKLHVKLDKAVVCKHWLRGLCKKNEKCEFLHEYNLKKMPECWFFSKYGECSNTECHFLHIDPNSESKECLWYKRGFCRHGLMCRNKHVKKRLCYSYFYGFCIDGPECKFGHPKAELPVNIEQRGIEEKDIISKPKPPIDADIEQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY49</accession>
    <name>L7JY49_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1324"/>
    <dbReference type="HOGENOM" id="CLU_622872_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY49"/>
    <dbReference type="OMA" id="KIHIRCK"/>
    <dbReference type="OrthoDB" id="10510306at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="484" mass="56117" checksum="40E3F1330A15B6CC" modified="2013-03-06" version="1">MLYNLLFNTFGVPIILVVTAMMYSITRTNSDERCYTYTMNSVYIKRESDELLVVGDGWMYTVGIWYFDVLYVLCVLGERSVDMVECVDTLLRSRGRNGDSTGNNDNNRENSRENSREKENSRENDRNNDKENSKEDNTDKDKENNTNATDNNNNTNINTPYLQHLPPFSKFIKTIILCQSLPFKISFTAHHLLLYNTYSAYVPYRIYTLRNARTPLRIRNMNDVVKEIHNRMDVLEYADDCTINSLGVFIKNGYLDDMVIYVFDGDIVVFECSNGNMDDVVDDEVDDEVKDDKVEDGRVDDEIKDKVDDNQVEDDKLKDDNQVEDDKLKDDNQVKDDKLKDDNQVKDDKLKDDNQVKDDKLKDALNSNKNNNSTDQYLNHYLNQHHITYKQMKIKTCTTAQANIKIHIRCKNAIDGHLTLRKRGPVLFVRRGLKSIIMKMVPCTEDERWRSYCDSVGDCCGTLEKCGEDNEGVMYLKMIGVIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY77</accession>
    <name>L7JY77_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0619"/>
    <dbReference type="HOGENOM" id="CLU_1284082_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY77"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="215" mass="24523" checksum="23924069AA667BD6" modified="2013-03-06" version="1">MIKKYIRKIETIPMLISYHTCLFPWLMSILCIVIYENQNKNKKHGIFSDVKRANPPMNNNALQIYEDLRACMFARIAGSHIVADETKLKPQSTGLRKMQSSNMVYSGNQLIGVYAPVHYGASERNKDEQHCLIPVSLEGGSNDVEGNSMLQLNEEHYYEVISVDKHDRNVQQKKELSHQFITLLAALIGCSFGMCCFSLFLCIGACLMFIYITMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYC1</accession>
    <name>L7JYC1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin elongation factor SPT5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Chromatin elongation factor spt5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYC1"/>
    <dbReference type="STRING" id="72359.L7JYC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0961"/>
    <dbReference type="HOGENOM" id="CLU_034563_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYC1"/>
    <dbReference type="OMA" id="AIDTCKF"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="579" mass="64529" checksum="0243E77B073BBFCC" modified="2013-03-06" version="1" fragment="single">VSAKQQVSLLPSTSSPKLWLVRVKPGKERQVLFKIISERHDNIYSVIIKDGLPGYVYLESFHKQSVLNAIDTCKFVGGRVNVVPLDEMVEVMTYRKNEIVLFSYVRMKKGRYKDDVGMIVEKISDEMVRVRLVPRIDGVRRLFVPEEHDNVIRVSRGFVMNKEFYDEKGFLERNVKVSDLRLGESPSINELRDFKSREYEVGECVTVKKGELRTLSGRIKTKRENELVIQTDTRTYTVSERDVQKDVRLGDEVGVKNEGTGVVVHVQGQSAIVALDNFSRELCVPVDELTRPQEVYTVKKNTNIRRARRDPLVNKKVTVIRGSYKGFDGVVKDVHRDNVLVQLVSNLKRVEVRKSEVMLVEDGWRGGLGAVNVGTRTPGQAAFGGRTSDLSGAADVGTRTPGQIAFGGKTPDLTGAGGKTPGFELYGVQGTPRPDGNAPYKTPYRTPSRGGRSPPQTPGMGSRTPYRDQHKSPYKTPRASESVAEESASVYRGTQLLHQNKIVEVLDIIDGTVITHTSKIKLEHCQFVQPSKYDRVIVLRGNHAGCTGILVRVSDSKGTVRCAESGAINVNVEDMSRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYE6</accession>
    <name>L7JYE6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein DRG1 (ODN superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYE6"/>
    <dbReference type="FunCoup" id="L7JYE6">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0563"/>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYE6"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="300"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="376" mass="42338" checksum="A23F3B0E4D26CB0B" modified="2013-03-06" version="1">MSNIERINDIKNEMARTQKNKATAHHLALLKARLSKLTRELVAPPKGAKKKGSFFEVRKSGIARIGFIGFPSVGKSTLMNQLTNAKSVVAEYEFTTLKTVPGIMEMHQTKLQILDLPGIIKGASLGSGRGKQVLSVAKTCNLLVIVLDSTKSLTGLTTIKDELEAVGIRLNKEKPKIKFSTRERGGVNLISSVKIDEAVVKDVLKEYRINSCEIIIEKDYSHNANDAENEIIDDIIDTIEMHINPSSIVYIPCLYLLNKVDRISLAELEVMCRLRNSFPISSFHAWGIERLKDKIWKELNLIRIFPKPKNMEIDDPVVLRRNSTVADFCDAIHKNMKEKVTYAWVWGASVKHNPQRVGKEHVLYDGDVIQIVKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYG9</accession>
    <name>L7JYG9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin hydrogenase</fullName>
            <ecNumber evidence="5">1.12.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EC" id="1.12.7.2" evidence="5"/>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYG9"/>
    <dbReference type="STRING" id="72359.L7JYG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0506"/>
    <dbReference type="HOGENOM" id="CLU_683513_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYG9"/>
    <dbReference type="OMA" id="MRYNFVD"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="4">
        <location>
            <begin position="121"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="462" mass="53047" checksum="DA04ADB36E5541EC" modified="2013-03-06" version="1">MRRPHMNKKINPCIKGEKPFELTLNDCLACSGCVSMEETKITAEDLQNVPINLIMSHYSVLNLCNEIKKQQLKQNKDDSTNLHAITVKEWYAYLQNALRRKFSVKRIVNTYDYQQLSNYMIYNELLTKNKLILSECPGVVAYVERRRPDLIPYLSEVPSLQQMCAYLCEEEGVLTVGVMQCHDKRLEGGVRVDYVLSSKDIYEICSDVRINFEVDNNDRDIYDDVGVGNEGKGDNNGRDIHDDVGVGNEGKGDNNGRDTYDDVGVGNEGKGDNNGRDIYDDVGVNGKDNNIYETCNGVHTNDKDDNNTNTHNDRLSPEQHSKNSSEHVLTNEKEFLTGITPYLIKMLNLTIERIQTINKSYRVLHFKNSSLTFAHITGLKNLLNFLNDEEMRYNFVDIFLCDDRCFGGPGQIKNNVQNDYAHYFKLVGLNTNEEVIVPQVLKDKKRIFENRKIYRSNFKVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYH4</accession>
    <name>L7JYH4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1248"/>
    <dbReference type="HOGENOM" id="CLU_991065_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYH4"/>
    <dbReference type="OMA" id="WISKKNE"/>
    <dbReference type="OrthoDB" id="10272897at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="281" mass="32109" checksum="07B417B4C5A90A6A" modified="2013-03-06" version="1">MMEKSKLLIWIVSPTILGVVIILAPILLSWLLLRTADFTYVSTYESTWNDFATMLPNDMLNGGKAADNILVWISKKNEKNESVAIAKHIINTIDFKQEVEVFKEGVRDETYYPELFANFIDWDREEPENAPIPFTKMAEQKIIPRQNFLVRMAAKFLGDRTTCKIDKVFDFMLKDAPDGQGQYNAHIMHYDSNVLKIYQFLVNETDNGLKLKETIEIKLKDEQATTVYTDIIIKLGLLSIQNETIEQPAEENTETDTSLSINDQRSTGVDKDSTISNAPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYI2</accession>
    <name>L7JYI2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eukaryotic-type DNA primase, catalytic (Small) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993874">
        <property type="protein sequence ID" value="ELQ76106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYI2"/>
    <dbReference type="FunCoup" id="L7JYI2">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0918"/>
    <dbReference type="HOGENOM" id="CLU_1518912_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYI2"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="177" mass="20378" checksum="D040EC53BF820C01" modified="2013-03-06" version="1">MTDYKKEIERKHKTNTLKNKPVQNKDSNLVTQYDLNDVHVCDNLCNECIAQMNKLIDLLKKILTDNFGFSHVIFFFSGNKGFHCYVTDASARHFTGIVRQSVASYLKKHGVLVDENVTRDVKHLLKAPFCVHPKSGYVCVPVIEGVEKVHVSDVVCGNVNLERYYKYFEDFVNKMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYK0</accession>
    <name>L7JYK0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative WD40 repeat, subgroup, WD40/YVTN repeat-like-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYK0"/>
    <dbReference type="STRING" id="72359.L7JYK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0917"/>
    <dbReference type="HOGENOM" id="CLU_568834_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYK0"/>
    <dbReference type="OMA" id="QEMILFR"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="580" mass="65548" checksum="8F63A5B6E46D8983" modified="2013-03-06" version="1" fragment="single">VVGGKSMKKDYTFEITKHTLYFHENASIYGLSSTENHLLTAGSDCTVRCWHITLKSKKNKHVLCYPDSSSVSFAYCCTLTLPNSINTIRSCDKYVAVGTTMGEVYVFKEMGCTFEECMVRGGDGDSCNEIAFVRLGVIVCGFESGRLMMYEIIENDELKEKRNCTGTPEDNTEKNEIDNNELSNTIANSSVSEIVMQNDDQAPTNNSKVVKKRRIKPSQVTKLLSYKLLNVIKPHSLSVQGLSYNTKYNILSSFSKDKTMKVFYITNKMTIIGKFSDVFADEQEMILFRRYTFSHDNEFLFVGGCLGNLLQILHYPFCGTCVLGRIGPFEAHVSVIYEYGRRNYCTLPEKTNYESENAKLIKERWHKIINDGCVQSEGDDQESLSTNQPQENIREMIGDMSTMSGIGNGSEKENASNKFADPNMFVSMSCLNTKRFDDKKTENSDKNSGRVDHIPYNDAENVIIPDPRLSTEKNVSSNKDCDSTRTINLEIVNCTSIDEKNDQTCIDCIFNMNNYGFRISNIDKLVFFAVKNHLYCMNRTGIVCKMENISYKGITDIVSHKNVIFVSSVDGLLSSVRFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYU4</accession>
    <name>L7JYU4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MCM7</name>
        <name evidence="8" type="ORF">THOM_0319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYU4"/>
    <dbReference type="FunCoup" id="L7JYU4">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0319"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="L7JYU4"/>
    <dbReference type="OMA" id="ISIHRAH"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="7">
        <location>
            <begin position="319"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="694" mass="78446" checksum="79B5BC7173559FE8" modified="2013-03-06" version="1">MSSELKQEKIDLNYSADKSVLSSFIHFFTDNNNEPKYLNMISHKKIALDLNDIAIHDHMLVNRLRSNFMTYLRMLYEIIDGVNTPSDVAMIHRLERMKEKYPGVDAAKKFPPALMRDYVLDVVPHAQHTLGIRMLRSDKVGHFVTTRGIVTKVSHTRPSIKVAVYVCDSCGSETYQQVNNQEFTLLAVCQSEKCKTMKIRGTLSLITRVSKFEPFVSVCLQEMQGDTPEGCIPRVINIEMKDAEVRPGDCIYVCGVLMARQLIGLMNEIYLEGFGIAECKTKGTDDLMVDGEHVQDESAVIGSIEHCDDVTEIDRTNYSVQNLMASFAPHIYGMYDVKKILLLMLIGSPSITKADGMRIRGDLNVMLMGDPGIAKSELLKYCIGLARRGVYTAGRGSSGVGLTASVLRDPFTKEFVLEAGALVLSDRGICCLDEMDKMDENDRLSLHEVLEQQSISINKAGINVRLNARCCVLGAANFKKGFYDDKKSLEHNTGLPVSLISRFDVIAILRDEKDESRDRELAEYVARQHLKEGDESGSSAVLSHTDLKTFIQKAKTLNPRIPSHLNERIVGAYTAARDKYERLTPRFLLSLIRLSMAHARLRLSEEVNEEDVEESVRLLEVSKLHKVKDRQRELSPKYQIYNQIMKMKTSGRTLRLEDVVRSINYDEQTILNVIKEFEENGIWVVEDGNLHIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ14</accession>
    <name>L7JZ14_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative CT20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1005"/>
    <dbReference type="HOGENOM" id="CLU_174999_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ14"/>
    <dbReference type="OMA" id="PENIWDF"/>
    <dbReference type="OrthoDB" id="2191697at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043189">
        <property type="term" value="C:H4/H2A histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="99" mass="11606" checksum="01BADFFBF3F99244" modified="2013-03-06" version="1">MCKPMVQKRANASEPHIKIRILKALGHITPVGIHKHLLMLKILRNMKKPNIITPENIWDFINESFSAYKYDKDDFKRFIKQGKGYEHTYTTVIAPSLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ17</accession>
    <name>L7JZ17_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein SA (P40)/Laminin receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ17"/>
    <dbReference type="FunCoup" id="L7JZ17">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1010"/>
    <dbReference type="HOGENOM" id="CLU_058171_2_0_1"/>
    <dbReference type="InParanoid" id="L7JZ17"/>
    <dbReference type="OMA" id="QCHLGAK"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="241" mass="26910" checksum="0DDE8983C361F214" modified="2013-03-06" version="1">MSQNMIKKPSSKVVTALLQCCCHLGGIQANIQMRDYIFGTRPGDKINIIDIQKMWDKMVLAARLFLSIKDTKSIMVVSNKDFGRKAVLKFCEATGATPITGRFIPGGFSNFEIKNVREPRLLIAADAFSDRQTIEEAAKARAPVIAFCNTDNSLSYVDVGIAMNNRSASALGAGFYLLGKIINHIKRGDEIDDNLRDGIESYIYRDADELNSLYQEAKREKEGEICMQEEPKNEEVSVNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ48</accession>
    <name>L7JZ48_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0697"/>
    <dbReference type="HOGENOM" id="CLU_3299681_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ48"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="4575" checksum="BE335AE9A1F7D3C9" modified="2013-03-06" version="1">MATFLGSCPENILVDFHNKKQKIIFLKTIIYVGKIAFNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ64</accession>
    <name>L7JZ64_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993821">
        <property type="protein sequence ID" value="ELQ76738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0264"/>
    <dbReference type="HOGENOM" id="CLU_2544215_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ64"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="83" mass="9969" checksum="8361AA039B29382D" modified="2013-03-06" version="1">MEDNFVVRKIIETQMWAVKDAFKRSIKNMYTYLNNYGSVEYLINMSEIFDDVDKLKDNLNDWINGFIIIYQKNLRTFKNSSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ72</accession>
    <name>L7JZ72_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0658</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ72"/>
    <dbReference type="FunCoup" id="L7JZ72">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0658"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="InParanoid" id="L7JZ72"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="166"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="389" mass="44011" checksum="580E26ABBD1CA38F" modified="2013-03-06" version="1">MSFTTAYFMNETQRLHSEIENKKMELKKLNKKRYDLNNQVRMLKEEIRIVQEPSANVGTVIKKMGKNKVLVKTQPDGKYLVDVDDKINIEELKLNTRVALRSDNYKLIRALPTIVDPIVSLMMVEKVPDATYDMIGGLKQQIKEIREVIELPIKSPELFENLGITQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGTELVQKYIGEGSRLVRELFVMAREHAPSIIFMDEIDSIGSTRIEGGPGNSEVQRTMLELLNQLDGFENRSDIKVIMATNRIDILDPALLRTGRIDRKIEFPNPNAEARLEILKIHSRKMNLVRGIKLNEITPKLVNASGAEVKSVCTEAGMFALREMRVHVTQEDFELAVAKVMKKADDPASDLRKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZF2</accession>
    <name>L7JZF2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40s ribosomal protein s10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZF2"/>
    <dbReference type="FunCoup" id="L7JZF2">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0394"/>
    <dbReference type="HOGENOM" id="CLU_089349_4_1_1"/>
    <dbReference type="InParanoid" id="L7JZF2"/>
    <dbReference type="OMA" id="AYFFITD"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="12711" checksum="3E573C1903485156" modified="2013-03-06" version="1">MNLTRDEMLTIKKYFFREGVCLVEEKSNQPHPELEINDKQVMKFMTSLVSKGLARKQFNWRHAYFFITDEGIDALKKDLSLEDNEMPLTHLETNLNVGYAVENEEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZH3</accession>
    <name>L7JZH3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0150"/>
    <dbReference type="HOGENOM" id="CLU_1662140_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZH3"/>
    <dbReference type="OMA" id="YYILHSI"/>
    <dbReference type="OrthoDB" id="10340790at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="170" mass="19740" checksum="FE021981E8689D0E" modified="2013-03-06" version="1">MSTLFQFRDAQTKLPFYYILHSIVLLVYALAFRLNNEIFSDLKIHEARLNVSLLTALNLYKTYFISVVLVTQNLFMAKVYVVVIAYETVVPLAFLARILTADTKLYGLVIAVLAVVIIDIIEMVTFVWLFSQFERDFLWEDNKRIGLDPKINGRLITLIKTHIKQEKNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZS0</accession>
    <name>L7JZS0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase, protein kinase C</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
            <ecNumber evidence="5">2.7.11.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EC" id="2.7.11.13" evidence="5"/>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZS0"/>
    <dbReference type="STRING" id="72359.L7JZS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0793"/>
    <dbReference type="HOGENOM" id="CLU_488530_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZS0"/>
    <dbReference type="OMA" id="DEQFEMY"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="549" mass="63378" checksum="3FF72CB99188D824" modified="2013-03-06" version="1">MAVFDEQFEMYERIGYGRFGNVYRAVYKPTGEMMAVKIIRKDALHSCYIANEVRLGSLILHHGIVHVKFLFHNDTHFFIAMELLEGVTLENLINSQRFTEDEARVYVFEIVKALHFLHSHHIMHRDIKPSNIMVCKTGIKIVDLGTLSLFQGYPDPKNNMTWVARCDTNERGSVYETYNISKTDENAISILNSLGRNGNEIINSMNIRRTTAERCGTPLYSAPELLFVRANVTDKVDVWSLGCLIYRMITGVEKFSGNDSSEIEDSILNKPLDIDSMCVSESLKKLLERMLQRDYVRRISIEDVLASDWLSSLSETYMTRGVCVFCGDSLDMTEQIESDSLFKICNKCEDQRREEMGKYEMETCFLNDVPIGKLNQELVEIKLTMWGLCKSLDAAHRNNLKKLFALRPEAVDQVGEIKYSREVALEVAFSRQLKARFGKPRGCFTLPDICSYMSCRVNYKDPNLRSLDGKQSIFKIRMFFKNVIFKTLDLKTRMIRGMSYGIIVSNEPSGPKISLSRRGGRISDFQNFYVMIRNNFIRMERIDNSWYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZS4</accession>
    <name>L7JZS4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0798"/>
    <dbReference type="HOGENOM" id="CLU_967091_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZS4"/>
    <dbReference type="OMA" id="HIPRICC"/>
    <dbReference type="OrthoDB" id="10434103at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="290" mass="32579" checksum="E9C277D1DDBC568C" modified="2013-03-06" version="1">MAGRRRNILITITIAFLVAITVAVCIFLTIRYTTKKAKVPEKIQCVLKGNGVDCFIISVLQALYNLKNYKLFLDEIVSSGNNNIESILKSIHKDMEARTDSSMDISAYRNRLLALIRSNSSNTGITLSVNEQNDADEFLTGALKTITNKYIVKKYFCFRNKGLSQAGVYYYDDNYDIAAIPFDKDINDQQANVNYVLQDKNNTHIPMICFGIGAVHAPKIYPNKSIQIFGKRFILRSGVYYTGSGGSGHYFAICKIGNVYRRITFGCCNEISLSNINARANMRLAFYEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZU2</accession>
    <name>L7JZU2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding Cassette (ABC) Superfamily</fullName>
            <ecNumber evidence="10">3.6.3.25</ecNumber>
            <ecNumber evidence="10">3.6.3.31</ecNumber>
            <ecNumber evidence="10">3.6.3.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.25" evidence="10"/>
    <dbReference type="EC" id="3.6.3.31" evidence="10"/>
    <dbReference type="EC" id="3.6.3.41" evidence="10"/>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZU2"/>
    <dbReference type="STRING" id="72359.L7JZU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0057"/>
    <dbReference type="HOGENOM" id="CLU_020421_1_1_1"/>
    <dbReference type="InParanoid" id="L7JZU2"/>
    <dbReference type="OMA" id="KEISAHA"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="465" mass="53318" checksum="1866F508A65CF0F4" modified="2013-03-06" version="1">MLIELKDVSIRVKNRSEKGKKVGEHILSNVCGEIRAGFTAVIGPSGCGKTTLLRTILGKVPSEYISSGEISYCGRKRVLDEWTRMTTYLDQCESVSAFLTAKECLYYAAVFSSKYTKSVIYEKIEEIAKKLSLKNVLNCAMVNLSGGQVKRVQIALELIIDMPIILLDEPTTGVDNVLAYRIIEFLKEIAGYNKIVVCSIHQPDDRTLMLFDRVILMNWGRIVYNGTVGNIARTIAENGFLNIDNLEISTYVLDFLNTGRVKYVDPSEHCQIVDNMVSKYLLTCRKHKRKYVEKKSNEFYLRFAPCFNHIIMLCKRDLKITFKPLRLQIFILILYNLLFLALPFVPLSLYKGNTSETVLNTEKQILNLEKELTNHIQSSLCFCLSNVALYINQYKNQTVFLAVKEINRHAYTITSYYIGTMLLSITYFLPVFILDLVLFRVLSRDLFDNMSLVLITLFFFSTIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0L1</accession>
    <name>L7K0L1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0L1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0119"/>
    <dbReference type="HOGENOM" id="CLU_2039699_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0L1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="14368" checksum="AB08F3DA864B80EB" modified="2013-03-06" version="1">MFVIDGAFYADPENLCFLPKSLEILVISYYDINFSNDIFNGPFLKLRELYVRLFRDFEDDEMLVLSQSLVDFLNGLFLYIDRSCLEHLLIVEKRINYQIDPFTLDITSIQYETLEFGIELR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B2C6F2</accession>
    <accession>L7JWI4</accession>
    <name>ISD11_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName>Protein ISD11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Iron-sulfur protein biogenesis, desulfurase-interacting protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ISD11</name>
        <name type="ORF">THOM_1240</name>
    </gene>
    <organism>
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="452" first="624" last="628">
            <title>Localization and functionality of microsporidian iron-sulphur cluster assembly proteins.</title>
            <authorList>
                <person name="Goldberg A.V."/>
                <person name="Molik S."/>
                <person name="Tsaousis A.D."/>
                <person name="Neumann K."/>
                <person name="Kuhnke G."/>
                <person name="Delbac F."/>
                <person name="Vivares C.P."/>
                <person name="Hirt R.P."/>
                <person name="Lill R."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18311129"/>
            <dbReference type="DOI" id="10.1038/nature06606"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH NFS1</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for mitochondrial iron-sulfur protein biosynthesis. Interacts with and stabilizes the cysteine desulfurase NFS1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with NFS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="EU282037">
        <property type="protein sequence ID" value="ABZ79025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B2C6F2"/>
    <dbReference type="SMR" id="B2C6F2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1240"/>
    <dbReference type="HOGENOM" id="CLU_2741835_0_0_1"/>
    <dbReference type="InParanoid" id="B2C6F2"/>
    <dbReference type="OrthoDB" id="10277562at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032047">
        <property type="term" value="C:mitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056326">
        <property type="entry name" value="ISD11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23511">
        <property type="entry name" value="Microp_apicomplexa_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1025">Mitosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382934" description="Protein ISD11">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18311129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="71" mass="8497" checksum="A9C6A7FF9CD44AC2" modified="2008-05-20" version="1">MDKITNTYSALLSSITNFKNRNIRAYFKRKAFDEYLECVNGVRPVEKYLKDNEELKGVMDRQSVIYNFYED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-02-22" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D5JAJ1</accession>
    <accession>L7JVY0</accession>
    <name>AOX_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName>Ubiquinol oxidase</fullName>
            <ecNumber>1.10.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Alternative oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">AOX</name>
        <name type="ORF">THOM_2158</name>
    </gene>
    <organism>
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1000761" last="E1000761">
            <title>A broad distribution of the alternative oxidase in microsporidian parasites.</title>
            <authorList>
                <person name="Williams B.A."/>
                <person name="Elliot C."/>
                <person name="Burri L."/>
                <person name="Kido Y."/>
                <person name="Kita K."/>
                <person name="Moore A.L."/>
                <person name="Keeling P.J."/>
            </authorList>
            <dbReference type="PubMed" id="20169184"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBUNIT</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Alternative oxidase which function may be to reoxidize reducing equivalents produced by glycolysis such as ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 a ubiquinol + O2 = 2 a ubiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30255"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="EC" id="1.10.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Found as monomers and homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text>Microsporidia do not contain mitochondria, but highly reduced mitochondrial organelles called mitosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.11"/>
    <dbReference type="EMBL" id="GU221911">
        <property type="protein sequence ID" value="ADE43749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="D5JAJ1"/>
    <dbReference type="STRING" id="72359.D5JAJ1"/>
    <dbReference type="KEGG" id="ag:ADE43749"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2158"/>
    <dbReference type="HOGENOM" id="CLU_874887_0_0_1"/>
    <dbReference type="InParanoid" id="D5JAJ1"/>
    <dbReference type="OMA" id="RISKDYW"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102721">
        <property type="term" value="F:ubiquinol:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1025">Mitosome</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0679">Respiratory chain</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000415493" description="Ubiquinol oxidase">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Fe cation</name>
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            <label>1</label>
        </ligand>
    </feature>
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        </location>
        <ligand>
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            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q26710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="20169184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="318" mass="36489" checksum="4F240AE050534F4E" modified="2010-06-15" version="1">MLTKNNSLLSRLPARISFGLKISNKNVNSTYSNVASAYCEGATYKKNGVSRLQNELLSQKTNNETIPVPLQHFIRPAAKHSIFTQIKGYGERSRPEFERPITLEELKSLDYESGKHFVPQSFSDTFAYLIVKGLRAFADLYFQKDYVRRVVVLETVAAIPGMVGGMFRHLYSLRNLEDNGEAIKKLVLEAENERQHLLTFLAVLKPNVLDRMLIKLGQFLFFNGYMVFYFVAPRTAHRFVGYLEEEAVRSYDAFEEEILLGHIKNVEAPRISKDYWNLPEEAMLIDVVRAVRADEAEHRDVNHKMADSKSFSLAHNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRM7</accession>
    <name>L7JRM7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994072">
        <property type="protein sequence ID" value="ELQ74128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2956"/>
    <dbReference type="HOGENOM" id="CLU_957125_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRM7"/>
    <dbReference type="OMA" id="ESFYAIF"/>
    <dbReference type="OrthoDB" id="10401724at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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            <begin position="12"/>
            <end position="34"/>
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    </feature>
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            <end position="76"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="109"/>
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    </feature>
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            <end position="234"/>
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        <location>
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            <end position="267"/>
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    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
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            <begin position="221"/>
            <end position="279"/>
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    </feature>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="288" mass="33777" checksum="06DB59720BBD2B4C" modified="2013-03-06" version="1">MTFKLSHCMSARIALSTVAGLALITTYYCLKYYQNWRIELHNLEPSSTEYNVRIFTTITIESFYAIFILLANFRYFLNEIILFYNNKYKSMIVIFLYFLLLGVSSKWSISEKNVSYRFIIRDVIFYPFFEEFFFRHVLFQNLKYGMVGIERIWIMNNEPGDLKADTSSVTHTDDRSDVTLSTRVAGTTIKNNIVHRKLIVKDLNTYTVLETADITFLLVIIYFAVISSILFATAHHFYDVILINDYIYRVISGIFYTIFVDLTHNLLVSLICHSVHNLFVLKCQSDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRR0</accession>
    <name>L7JRR0_TRAHO</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi incertae sedis</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
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                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="25"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="105"/>
            <end position="127"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="533" mass="59997" checksum="3A3E39C2C997D9AA" modified="2013-03-06" version="1">MNPKRTFSISALISTSLMAIIFQLMDMLSYGRAMFKSDDPEQNIIVQNIGMLCYIYSTIWSQLLFNYFSKIDAAIISSVIVESLPFMEENVGKIINKHTSGLNGYITNFIAILLICSVGFGIVSLLLKYGRAGHLISLIPKAVVNGCLGAIGLTQFPLGWSALVPKGYEKKYWLLCTIAIAVAVILFILQFKLAGADFLIPLYTLIIITLFYGIAFIFVGASDRMQYLRDNNWLPIKEAKILYPNYVLSRIDLSTLNWRSFVYNFFNILTVIFFNSVHIAVNLPAYKISTGVNFDFSDELGTQGFSNLFTFIPCYFVACYSIAFYKAGGTLKIYGYVSALAMILIAVFGLTIKGYVPNFVLSMLPFVMGAGFLYSSFYEPIFTTSIYEYSISVVVCLICWLTGQYIVGVLVGLGICVAYYIIASRRKIALYDSLDVIESDNIKVIVVDYLLCFLTAKRFVLPEYTDILIMDFSRCQGVDWLGMDLIVSCCEKARKVYFIGSPINLRVKRLKDVQNLVLVKDYSCLYFQMSEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRT7</accession>
    <name>L7JRT7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994067">
        <property type="protein sequence ID" value="ELQ74163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2919"/>
    <dbReference type="HOGENOM" id="CLU_080517_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRT7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="210" mass="25098" checksum="4C1EE47844FFFF92" modified="2013-03-06" version="1">MRKYIFWCQIIHQMRYDEDLENRVEKLCFTLHAAENKTEPTGLYTSNPCFYDLMQEIQNIAYYHVLEDKQGSILLTSETEKYESLSPMFISFKDFQNTFVPNFLKMDSKFLIANREYIKDLCAHFPENGTNRIVVDVEFSDICNGRTDWEYLCYDIKNEKDVMAITSDFLKSSFIERFIIRLKKENCDFSIPFPMNVELYFDNCNINRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRZ0</accession>
    <name>L7JRZ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2840"/>
    <dbReference type="HOGENOM" id="CLU_2656209_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRZ0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8713" checksum="5677FDFD8FC7E5AE" modified="2013-03-06" version="1">MLSHINNGCDLATLNAVVRDKFSTYYRYRTNESNEQEIVNQRPVAMVGSSGSEEHLCGKMCKMIIEQPLKNEERMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS91</accession>
    <name>L7JS91_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex, Nup98 component (Sc Nup145/Nup100/Nup116)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS91"/>
    <dbReference type="STRING" id="72359.L7JS91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3194"/>
    <dbReference type="HOGENOM" id="CLU_501161_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS91"/>
    <dbReference type="OMA" id="LEQCYDE"/>
    <dbReference type="OrthoDB" id="2193331at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="544" mass="56256" checksum="2E292D5ED2B5CD69" modified="2013-03-06" version="1" fragment="single">VSPFNMQNNDKKDTFFNLFPNNQQQNQRFSLGTGNKDNNTGLFTNTGSFGGAQGGTSGGLFGTGPGFGSQTNTGTGFMNNQGPMPSTNVGQTGGLFTAPATGSSGIGGPGSFGLSNAANTSGSLFGNTGTGAGQTTGGLFGTQAANTGTGTGQTTGGLFGTQAANAGTGTGQTTGGLFGTQTANQSAGTSSGLNTGPFSMPQTNTQQQSTAGLFSTPNQNDAGTTLFKTQPSVGTTNLFSAQPQATVPGGSLFGSTPQNTAGAASFGAQQGVAPYNTQGIAGTTISGPAQPATASSITGTMGGQTIGNVAQQPATSGPFGVAAPQPISTYGETTTKPGTIGASFPESKDSSAANAAFTNVFSPAKPVVTQPNTKQETSAIAQPSVNVPASTTSEAVDGNSYVDITSVPLNFRQKSFNEILTEISAELEKDVKFFKKKAEEVFAQDEKIIRARNTYVKLLDRLKAEEDKINELEENVEFLFKWLESMKIDDSVKYLNELEQCYDEFMDGVMQQKNIEDEIAGIINENMKLISIIDEDLEYMESMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSL0</accession>
    <name>L7JSL0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_2615</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="JH994039">
        <property type="protein sequence ID" value="ELQ74468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSL0"/>
    <dbReference type="FunCoup" id="L7JSL0">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2615"/>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_1"/>
    <dbReference type="InParanoid" id="L7JSL0"/>
    <dbReference type="OMA" id="YMRMAGH"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="412"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ74468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="546" mass="63296" checksum="69A37A289A823EBC" modified="2013-03-06" version="1">MSSSRKKVITAALPYVNNSPHLGNIIGSVLSADVYARFCRKSNEKVIFVCGTDDYGTATEITARKDNTTCEEVVKHNRQIMIDVFDWFSIEFDCFGQTSDPEHSKVVQDIFHRIIDRIEEDVMQQYHCSKCEMFLADRYLTGTCSKCKSYGLQGDQCDACGILLKIDEIIDPECAICGERPQIRETRHLFLKLNELADDLRLKYEKNSSRWSKNACEITLQWLEKDLHKRCITRDLKWGVPVPDMNKVFYVWFDAVIGYFSFFKMYVERSENRKFESLKQLEEDFLSYEFVQFMGKDNVPFHTIIMPAILDFIANKLSVTEYLMFENKKFSKSKQIGIFGSDLIHNEYGTCDLWRYYLVKVRPETKDSNFSVTDFLNSTSDLQNNFGNLCNRVLKFIKNKMTGRVCFKGALNSATRQEFVSKINDLLSEYKRVMCHIKMKKGLTVLSEMCMVCNHFLQKTFEHSVDQDAKNDSFALVFSVIALLADLYEPFIPNICADLHEMCEIKPRTIGDELQVLDEHDINQNVRALFVPLGDEILENLRNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSN5</accession>
    <name>L7JSN5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3013"/>
    <dbReference type="HOGENOM" id="CLU_3263276_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSN5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4772" checksum="21BB44CCE9352831" modified="2013-03-06" version="1" fragment="single">VMSSVRDIEGCYCLFIKENNLKVQVIMIGGKKQLVQEVLITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSW7</accession>
    <name>L7JSW7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994036">
        <property type="protein sequence ID" value="ELQ74524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2549"/>
    <dbReference type="HOGENOM" id="CLU_1469297_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSW7"/>
    <dbReference type="OMA" id="CISVDIN"/>
    <dbReference type="OrthoDB" id="10325745at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="184" mass="21080" checksum="29FC78537C0A6401" modified="2013-03-06" version="1">MFLLYISYILADSFYIQNVSTKKFLAKSKANEEIVLIDDIKEASEFSLKPSEKINEEYIQADDMTLTVEMEESKRDHNASLPIYFDKEKQTEDQLFLIVQRPKGEVRLMIKDMCLSVDIDHEKLIAAQCLDNDINNLFKLLDAQGETDNKPPINIAKLEALKEAAQVSPKLREKIGMDYLDSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT46</accession>
    <name>L7JT46_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994065">
        <property type="protein sequence ID" value="ELQ74186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2899"/>
    <dbReference type="HOGENOM" id="CLU_1009006_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT46"/>
    <dbReference type="OMA" id="VECVENE"/>
    <dbReference type="OrthoDB" id="10400316at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="275" mass="32108" checksum="939652396E921CA9" modified="2013-03-06" version="1">MSSFPLDSTFLTKDVENDRKLTMEDVEVEYEKIREQMYKEMEIEKVQNNIYQKLYNKMKSNSFSFERIQKQDKRSLQPKNDQYTITESPKMSNMGNDGIEMVDKVKQDAYTGSEGIVGTIVESEIDDESDIVDLNNITDSEEGVTQQDPYKSKYLDVEAEEGSTGSEVDVPYDNFDYAKDIKRQDDIIKRLEKRYLRKKKVEKLEPLFKVEDVSSSEENLEFVNLSTDNIECNIVKDEDSVECVENEKGRDLNEYMVDEDINPYGLMNLSRNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT51</accession>
    <name>L7JT51_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994062">
        <property type="protein sequence ID" value="ELQ74196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2879"/>
    <dbReference type="HOGENOM" id="CLU_3052061_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT51"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6209" checksum="F26AF849DD18AE00" modified="2013-03-06" version="1">MLPKFFYLTDGLKRYFKLSIVAPCSEKVLLIYIISRVEKEASKMIVLNVEVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT95</accession>
    <name>L7JT95_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2833"/>
    <dbReference type="HOGENOM" id="CLU_2644901_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT95"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="77" mass="8708" checksum="EEF9C66CF120EC14" modified="2013-03-06" version="1" fragment="single">VASRLLVLRGMNITYQSCAKPLSGMASESAGDLYYLKLDLRRRLPLMSTSTNRSASIEDFHCHTRHCWPSLLLAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTF7</accession>
    <name>L7JTF7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTF7"/>
    <dbReference type="STRING" id="72359.L7JTF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2403"/>
    <dbReference type="HOGENOM" id="CLU_2644900_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTF7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="77" mass="8798" checksum="351FEA42008BF577" modified="2013-03-06" version="1" fragment="single">VDIKPLNDSAILNCEEIEDLLDVLNVELMKISDLNNNICEFKKITTKRKTDVRAKDSKMSKSSAVKELKKHKNVQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTG9</accession>
    <name>L7JTG9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide chain release factor 1 (ERF1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTG9"/>
    <dbReference type="FunCoup" id="L7JTG9">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3009"/>
    <dbReference type="HOGENOM" id="CLU_035759_2_1_1"/>
    <dbReference type="InParanoid" id="L7JTG9"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="415" mass="47366" checksum="2BD5D8C606FE1B9D" modified="2013-03-06" version="1">MQTMLQGLVWRLLYGCAWPTNQIRLKNFINYHPLCRMQEDEIKSYALKKQLLYLRDSRGNGTSMITLILPPRDQIPKALKMLVDEYGTASNIKSRVNRLSVLSAITSAQHKLRTFKNVPPNGLAIFVGTVMDNNKEKKISVAMEPLKPINTSVYMCDSRFHTESLVEQFKENETFGFIVMDGSETVFATLNSNVKKILHTLSVSLPKKHGRGGQSSVRFARLRIEKRNHYVKKVAEIANSLFTNEEGYILAGTADFKNQLFESAILLKNIKDRVIRVVDTNYGGENGLNQAIELAQDSLTMCRYLKERKVLQEFFKSLENDMVVYGQKNTLRLLDEQAITKLIVYEDVEGSVDDQPIIDWLLENYKRYNAELSIVSDKSTEGEQFKEGFGGIGGILKYKCYEDEGYESVESDEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTI1</accession>
    <name>L7JTI1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994029">
        <property type="protein sequence ID" value="ELQ74704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2368"/>
    <dbReference type="HOGENOM" id="CLU_2905765_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTI1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="62" mass="7177" checksum="C7C55BAD0370A717" modified="2013-03-06" version="1">MIRNENIAMVKISFLNYVEECKLHGNDPSIKLNFVILCKYDDKQPTKIGSLCFYTVNAKDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTJ3</accession>
    <name>L7JTJ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994028">
        <property type="protein sequence ID" value="ELQ74719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2360"/>
    <dbReference type="HOGENOM" id="CLU_344244_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTJ3"/>
    <dbReference type="OMA" id="NSEVFYM"/>
    <dbReference type="OrthoDB" id="10403539at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="807" mass="92210" checksum="BC201097B641CBFE" modified="2013-03-06" version="1">MLRNSLKVCTNFTHPYRLIRIPYKSLSLKEDTRMFLGQTDSSILNVEVFDCEERILRESYFMRIDLYVYGVAGGVLYCREKAERKHGGGKGSITDRNGVKTSKNRENALCEPRTVDYLSLLKNISSYINDTIADTITKLKNIKNVQCCALFYKLNLIERAYQNAKKNSEVFYMCMVKKMKMYEEKTGKERMVGKSKEIRMNRMMRFIKSMDEDKAVEFVVEIVNDVRPIIANRIVNTLQIKDGDKQRLLFYKTGMSCLRNGAGRLAVRFLTLSGCTGVSEMVDERKWRTAIFGKDYDVNAIAEVLCDEIVRVCSNTKIGRNARDGCLFDGKKGNTGQNDGTSGGILHEKDGHLTSEENSDHAAAMEEVKKADQKLYGDIHRKKIKIIPNNLKISSDFNENVEPKPLLEQKRDDKNARRTNNHVHTLTDNDKTLSNILTDALSVKVNVLTLRQQANDRSVANKLIDNRMLNERVHLKRLLSMCVVVMGRVREMLAADRDAQMHTFEMAGRAGNDEECLQDEFVHNKARNEPYDGTITEKSAKRQVVRTKYTQIYDYGPIKERDYHLNELSPPKNDKNMNLPDTCRPNNEKSTNMMDNTHVKNEKISNLTKALNVIMAISRKQPSYLLPADCVELEVINEEGVHKKTDGLFFSTSALLSKPVYYFLSYVVLRIKTVCRLLCLIFDSTAVNVNCNDGGGDRTIRINGVEGALIGIVVERNGLFYMVKINKLKFVRVDAMTKLRKLQSNRFLVQMNGTANNLEVLDGKIAYERRSAKESVFKVEGNVGSKYKIVYDLNDNYYRIWNGVIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTR3</accession>
    <name>L7JTR3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative translation initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994013">
        <property type="protein sequence ID" value="ELQ74868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTR3"/>
    <dbReference type="STRING" id="72359.L7JTR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2197"/>
    <dbReference type="HOGENOM" id="CLU_035147_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTR3"/>
    <dbReference type="OMA" id="GYAVCHS"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="5">
        <location>
            <begin position="193"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="416" mass="47411" checksum="C3495B9B91F0BFDA" modified="2013-03-06" version="1">MKPQVVAQCENGLILDVFSSESKVFPCLQYKIRNNILCYYTGTHLIVYDLEKEVELSKIVMERVKKIEVSTDCWSIGVLLQNKVLNVMMPGTACTKENKNMSAETNGDKCAAGIVFTVGDIFDFKMSDCYLLARSNKDLRVFKAENSKFSHEESYKNVKDFYVHGTVIAILDENGFFTVYKNQKKFFELFLEKVDAIDVRNSPKGNFLLLCTIKTKVGSYFGAKELILFDFNSKSYHMLDVSSPNYFTFIKGGYAVCHSSQPSVVSIYDYSRKEIRRFPKGIRNRIYYNGHGNIVCFAGFDNLSGMIEIYDAQTSNLISSLKMLGASVVEWSPCGSYFLVAITNALKVDNKVVIYDYFGRKINEKHFGNLINVEWIGCTSDFQYLEKPVQPNIYREESYVPPSFSNKGKKVNSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTS6</accession>
    <name>L7JTS6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2382"/>
    <dbReference type="HOGENOM" id="CLU_3302233_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTS6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="4593" checksum="0160B500741C3D2E" modified="2013-03-06" version="1" fragment="single">VNVRMRYEGRGDIKVGLFVRIGDIYTQISKNRRIRVVTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU37</accession>
    <name>L7JU37_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histones H3 and H4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU37"/>
    <dbReference type="STRING" id="72359.L7JU37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2474"/>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="InParanoid" id="L7JU37"/>
    <dbReference type="OMA" id="DMVDYGD"/>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="6">
        <location>
            <begin position="53"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="16508" checksum="5EE5D364BEB7A2F9" modified="2013-03-06" version="1">MARTKQTARKSTGGKAPRKGLAAKAARKTSAVDVGSATKRVSRYKPGNTLLFREIKKYSKSIDCLIPRQPFKRFVLSALSEIGMRDSVRFKAGCLNALQEALENFIVTLCEDAYLCTRHAGRVTLMPKDINLVMRIKRPMFLMGPCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU55</accession>
    <name>L7JU55_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2055"/>
    <dbReference type="HOGENOM" id="CLU_1378942_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU55"/>
    <dbReference type="OMA" id="QEYLECC"/>
    <dbReference type="OrthoDB" id="10319604at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="235" mass="27335" checksum="2EEBF33E2CD8413A" modified="2013-03-06" version="1">MLLHKTYKCISCKNRPNIKIKDNAYCNACFTTSFLRKLKHNYRCVLNKGAFIVHTGTVKSGTLVYALTKALYPYALESIRVFSDNVDWKGYSKLVHFDCNIKTYQEYLECCRTTSLSIDEKIVLEEKSMDDIACDILYDVLHANTHTLVENSGVAVCRDGLLFVRPFASISDREIAYFYFLYKDEIRVENVYAVDRLKEKIRSFLCKMSETNYSTVYNVVEMIRKYGDENKQVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU61</accession>
    <name>L7JU61_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2816"/>
    <dbReference type="HOGENOM" id="CLU_1801175_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU61"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="144" mass="17338" checksum="7A313420BC8B0DB9" modified="2013-03-06" version="1" fragment="single">VGINTLNPVFILYHFLIPDTLKKYRKYLQLNSDFHDRNSIIIKNLEFQIEELFPVLNCITKLKNFENHKTERLIFPHNLKNFEKQIKKKENNNFLSSLENRTQYQFEKEFSTIKQELLMFARSQPLLFNHLNKSPLCRHVSAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU94</accession>
    <name>L7JU94_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_2182</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU94"/>
    <dbReference type="FunCoup" id="L7JU94">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2182"/>
    <dbReference type="HOGENOM" id="CLU_013299_5_0_1"/>
    <dbReference type="InParanoid" id="L7JU94"/>
    <dbReference type="OMA" id="NPCLFAN"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102262">
        <property type="term" value="F:tRNA-dihydrouridine16 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102263">
        <property type="term" value="F:tRNA-dihydrouridine17 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="17">
        <location>
            <begin position="13"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ74875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="314" mass="36466" checksum="13E4F64BDAE58C2F" modified="2013-03-06" version="1">MDDLFKNRPLMVLAPMYKNCGLAYRTLSRKYGTDLCYTEMVHTQKFLQTKNKKRWLDDFVDSPLIVQICGNDPCVMRKAAEYFTGALAIDVNFGCPQLIAKRGNYGAYLQDDWQLTSEILKSLSSLEQPVTCKIRIFDDDKRTIDYVRMIEMSGCKMLAVHGRTREQRGQNTGLANWNTIKLVKEHLTIPVISNGNILCRRDVIDCLNFTKCDGVMVAETHLYNPLIFSDVKKSSFEVLREYFDLCGEATPIYEIKSHTYKILHKAFDQYDIYKCKIQKAGTFWEIRGIVDELERLCDCELKILKPRIRHMIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUA0</accession>
    <name>L7JUA0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Transcription factor, STE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUA0"/>
    <dbReference type="STRING" id="72359.L7JUA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2765"/>
    <dbReference type="HOGENOM" id="CLU_1013966_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUA0"/>
    <dbReference type="OMA" id="QWEEKYF"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="275" mass="32506" checksum="102234797B4CBAFD" modified="2013-03-06" version="1" fragment="single">VIAFCFISYHKNKRALVNTEMNMQTDKELFDFLSNAPKEFTENEKIKKFQLKNGDFIHCVLWNMHFYITGTDIVKILVWRFQNAGRQIVSLKKFEEGVFSDLRNLKPGIDATLEGPRSDFLEFLYKNGCIRTQKKQKVFFWYSVPHDALFCDALERDLRRETNLYAYSKYYNKQAYPPIPNHFAKQFNPYVEQMNWQHQNIPNPHPVPPPVVKPQPPVQKPPSNPPPPFSDIDFSQWEEKYFESQVQMPDFSEEKTDEFVEPDLIIPNKKGKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUB1</accession>
    <name>L7JUB1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome condensation complex Condensin, subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUB1"/>
    <dbReference type="STRING" id="72359.L7JUB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2141"/>
    <dbReference type="HOGENOM" id="CLU_023055_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUB1"/>
    <dbReference type="OMA" id="CECTSII"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="600" mass="70506" checksum="4A8642B800AFE9B3" modified="2013-03-06" version="1">MSETTPIHDIFVSLNNNNTLPEKKFYGSIDARTLNEILDYYILTKSQSVPKRVMQFLNLVLDFLEDNKAVLLNGLSYLRTYIDVKNKHVRKNVVHLLGMLIDRLNIILDGNSELRIQTSEQDKLFKQDDNTRDLVRSTIMKITERLFDKEHVIRKEVIKILSPYQDFMINKKTNVRRIFKDLLRYDPCPEIRNRVMMYLITSSSAIERIKDEDMSVRQTFFKVVLPHLKLKNLDTLKRCLILEKSVLEREFNAFLLLKSKIFEEYEFPAEIKNFVGDFLLLNTAEYADDGCKQIEENKKQLAKMLETIFIETSLTAKIFDDTYYENLDLEGAFILHAYLSFVESTKGRESLEMVNLEYFTAILYLKVKQVMEGDQNTRALYFVSLLFQLTNFYDVYEQKQSKYILSTIYKFFTAELPPKKEMLSQLIENGIILASSTDRTTFTNFLGSLITKSKENHTFLFLLCKYVMMHVKPFEMLHTAIISEIVLNNINIIDENSIILEIIFYYLVEKYNENGSLFFKNTNKLHESDGALDNANIESNKQLECANDVSCDILLNLLLEEKYFRPILVVDLFILFEEMRDVIRDKIVLLLQERINWGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUB8</accession>
    <name>L7JUB8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2002"/>
    <dbReference type="HOGENOM" id="CLU_861031_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUB8"/>
    <dbReference type="OMA" id="AYDHIQF"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="323" mass="38234" checksum="51CC75A41D6D87C7" modified="2013-03-06" version="1">MLKKLNKIRNRVYLRGGNPENYINAIKSLKKQDESNKEIYNAEIAIHRFDQSKSMEAKHRFMRKVRCKIPKLNDINPLYARYAEILSLFHTGDEKGNELLCTIADEIYEYDAFYTNLLKAREQGLKREIKDFSVLKYGITIKFNTETEKKYFLSHVLLRGDNFDVNLANYVTRLDKMKTKVIKSMGKVRSFPLKRAKIVDMKQLLQTFCAFLEQNYVEHENVKKLLNEVLRVEAFIEEIVYRIKFGRRNCDISDLNLECFPELNPYIIRDVKLFDNEAFTTKALIMDEVARSFEKKEILPFLPIFYDIAYDHIQFPEIDDDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUF3</accession>
    <name>L7JUF3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2129"/>
    <dbReference type="HOGENOM" id="CLU_202897_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUF3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8120" checksum="BABDFED37DE765F6" modified="2013-03-06" version="1" fragment="single">VKSSMSEQDITVVFCGESNDKLTKETKYGKKILDEIQDTYFKTIHKTMLSIIMVIIPLIIPEMDTCTFIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUK1</accession>
    <name>L7JUK1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Spc97/Spc98 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUK1"/>
    <dbReference type="STRING" id="72359.L7JUK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2622"/>
    <dbReference type="HOGENOM" id="CLU_506247_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUK1"/>
    <dbReference type="OMA" id="FEERHTY"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="591" mass="69787" checksum="7533C8C7B0BED0B2" modified="2013-03-06" version="1">MFNLAEKLFFRKITGQSNQLPVSNATLERAVLNDVFFFLCGLNTCNIKYHDNADILVNPAYVNANVLKAVRKLGLQIKSFEKYIFENEYCSDSLKRILSNEIEEKLNQFQLFLVSLRGKVQSIEDLLIKLSDYIDLFNEMERIVNIVHEKNGDEIINVVKERKDKMVHFNTFYDNLIQRFAIDINQRINLFICHGIIKTPFFMVKESDTFNFDEKFFTNKFFLESTHVPFYLRSSKLVLECGLYSNLIRTVRASVENQDETMDLQNDFYDIMHGTPSFNQTKKKDVKITVDRIDTEVRNFNEPASNDSYHNDEVISNILPYEYVVRQHRHKYRLLNDLCLRYFENEWANIRDYLFLMNSAFFTDVLSEINENILDNSKKNVLKINRMVSGTNISFYIAKNSIITIISKILNLELNYDLDEELCILDGLSIEYKPNHVFQLFFSKKNIDELELVFRMLFTLFVINFSIVRDNRSTFSNLILTLNNFLVSSFYTNNILKEILQMQINDLNSCVSRINELIRLSLRDLYITSFNVFKILGSYFVLCFKYIKYKKEDCEGLKKVILDLNTVIDNENYNIFLANLLYRMKKHIVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUK9</accession>
    <name>L7JUK9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2631"/>
    <dbReference type="HOGENOM" id="CLU_915855_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUK9"/>
    <dbReference type="OMA" id="NAEYCAF"/>
    <dbReference type="OrthoDB" id="2191917at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="295" mass="35011" checksum="6B2F05770E8DA9FB" modified="2013-03-06" version="1" fragment="single">VKPLTIKKINKRYILELNDPPIIQYASERPLQDKILLVDTDEKHGLKNIRNAEYCAFFDLTTRILQEGDFDIKPLSYEELNILYGSKYVKKFLRRRDLSESDINIDKIDMEKYAGNEQIIPIFNSNAQNTKNIYRLDIMFDKNLLREVGQLELNYTSVRIAEYKYRDSYKTHFIILDTLLYVLEKNYIPERLPYSDVMYDVLNAVLSTNEQDANVERKKYRRYDRYERYKFIAMACVILLIIHGYEIGAGAIPNFGVNDIEMRKIMKLLGCTWDKDKIRLTQIPKIKVRTKKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUL6</accession>
    <name>L7JUL6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1953"/>
    <dbReference type="HOGENOM" id="CLU_407210_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUL6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="675" mass="78882" checksum="0F76855C64AB4C18" modified="2013-03-06" version="1">MKCLNSFKNLRDMLHSHLALLFALSHFSIYHYIDTCNATPVSRRVTNTRRVVSSALIRLRGYYSSDKQCTCNKCCGSFMINVCQLTTNTVNMIKSIIADNISLKMRDNLCSADVLCLIDSIKKQTRQHHLFCYNLIRNIFRSAELLHRCAMIIKQPFDEREKRSLKKVLTVLRKDCFFSYENSHIFAIFEFDNTNKASLQCGIRADFFNCVRIPDRVLHMYISMFSESEYFDIFSLFGIIPRYIQLFNWSPEHIETFSCFCNDQSIILWISNMFLDISRISGYISMEFLTWKHLIAIEFQNVSFRSDNIFLGLRPFVHLEMVCFHKCCFVERLLFCNAENMLCKNITDFKNNVNDLGESKTLSLGLTAQMIENYSVQELHLEIWWKFDFQLFKMFKNLKFLGIGLKKRIVSARSTSGFFEDEHPTIIQCVASMPTLRKLLVRGLMMTAKASKALSKLQFVEEIRLYNIIFFEPFDSYEDINLWTNKLQVLSFPLRNYAEICVLIQNIELPNLEEIIIWKSSNDIRIPPIIMNVVIPNISKLTLFGFNDRMITSLIEILPGLTTLQVENSLNSFMIALFTADVIKHRVKKLIIVSSYVEDAVLEAVAAFTRLNYLQLNLEKSETNLNPKIFAKFKRKITLKIISPKLTLKDFYTMKKYKAIKDLQCYESKKRPKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUV1</accession>
    <name>L7JUV1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993990">
        <property type="protein sequence ID" value="ELQ75095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1965"/>
    <dbReference type="HOGENOM" id="CLU_155630_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUV1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="136" mass="16071" checksum="0F4C9878E7FD7A2A" modified="2013-03-06" version="1" fragment="single">VFRASPTFIIKFVFITGFECIHINSKDAIVTSATFNAVKNTYELFFFMSYDLLRKIEFSKKRFVDCLGSNITFESLDGTIFFKKIYVNYFEGIEKCFKKSVKRLYIYIKKHQLIEGLPDMSDILKRCDELDDTQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUW4</accession>
    <name>L7JUW4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Nucleotide-binding, alpha-beta plait, RNA recognition motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUW4"/>
    <dbReference type="STRING" id="72359.L7JUW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1939"/>
    <dbReference type="HOGENOM" id="CLU_1161853_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUW4"/>
    <dbReference type="OMA" id="WNESIID"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="239" mass="28356" checksum="61B41260841C09FA" modified="2013-03-06" version="1">MALIIKDIPSELSYDELYDYFTEYGRINDFRIKYNYGYLCYNNADVERRVFNTYHKVSGYKLNVDKAAQNETMERCSHCPVHCGGREREFMHNKADDRYHERVQRNGHPLDKFKVVLDNIPECNVIELKDFVRTFRLDPVYARITQSGQHGIVEFGSIEAKEDALRILDNVTFKNMQIGCRPYYTRERRGFDDEGYKRREYHAQDGQHMKDGMGEKMEKEELCEDLKGWNESIIDNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUW5</accession>
    <name>L7JUW5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993983">
        <property type="protein sequence ID" value="ELQ75189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1866"/>
    <dbReference type="HOGENOM" id="CLU_2335132_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUW5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="98" mass="11737" checksum="857942C6A39254E1" modified="2013-03-06" version="1">MEAIIYINMAKKADIIELDFFLKKHIIFVAEPSSEIVEDIKIEKIVQFYHETEKYVRFGADYFRRTFVLERSMIFFSVVSEHFSKRGLLVSARYFRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUX2</accession>
    <name>L7JUX2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994016">
        <property type="protein sequence ID" value="ELQ74841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2223"/>
    <dbReference type="HOGENOM" id="CLU_1579613_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUX2"/>
    <dbReference type="OrthoDB" id="10637286at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="169" mass="19903" checksum="7848019E31B875A4" modified="2013-03-06" version="1">MQLTPHAYLEEYRRAFVHNYEVLRGMVDELGSADSTSKRWVDLRRYVDVFDGHEIVFSNDGRYDNDNYDRPVNDNYDRHDRSIDDRHDNNRSINDRYINTHTNAHTDTNPIINPINHNFVPPYNYDTPHTIPSNTQPTIFNHSNHQTTNSPSDESKDTPKYAFGNIPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUX6</accession>
    <name>L7JUX6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1949"/>
    <dbReference type="HOGENOM" id="CLU_1154108_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUX6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="241" mass="27478" checksum="835396AC796A6181" modified="2013-03-06" version="1" fragment="single">VKNPMLSFRSIHFIFYFSDIFSTSEDEETNANQENNMLLNTISVNQSHNVRDICSYEPVPVQIDSESVSSDNEHDGAVAIRIKTQNLSLFRSAKEKHRNRATNLFIEVNPITHKNDDVNSENDSPCTSLPSYESVFVDNTTELPSMSTNNARCAKENKLLIQTKRIQININTSEPEEDEIIRRSDSFHGQESALKQLESCVGVSKDLLQIFTYLLCLISLVAIIQSLITTFFDYYSQNYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV06</accession>
    <name>L7JV06_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication factor C, subunit RFC3</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JH993973">
        <property type="protein sequence ID" value="ELQ75308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV06"/>
    <dbReference type="FunCoup" id="L7JV06">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1751"/>
    <dbReference type="HOGENOM" id="CLU_042324_5_0_1"/>
    <dbReference type="InParanoid" id="L7JV06"/>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="353" mass="40664" checksum="AED52CE85D3A29B5" modified="2013-03-06" version="1">MLLDQKYQPKTLDDIQFNRKHASNLKNFTLSTIPHLIVHGRPGCGKRTLVYAFINHLFGKQPKTHHRSIEVVSSSDKKITISYVESEEYVEICPSDYNFKDKDVIQDVIKKMAETKPILSLISRTKSEKLKLIVITKAEKMTKDAQAALRRTVETYVDNFRMIMICNDTTGIIDPIKSRMLCLRVTVASSDVLLKTLSEINDVECIGSDEKTLKQIISDSHGNFRRALFFLQRMQLNSTGEEKTKRLKKQEGEFKLEWETVVTDMVKMMVKEQSNTVVMNIRSHLNELLIKCIPPRLILKALFETLMSTVKQTEYHNLCTLTAKYDCRITLGTKSIFHLEAYVIAVMLLLQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV09</accession>
    <name>L7JV09_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin family protein (P-loop GTPase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV09"/>
    <dbReference type="FunCoup" id="L7JV09">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2511"/>
    <dbReference type="HOGENOM" id="CLU_017718_7_0_1"/>
    <dbReference type="InParanoid" id="L7JV09"/>
    <dbReference type="OMA" id="ERVHVCL"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="274" mass="31405" checksum="1F9150C69CC8CB8C" modified="2013-03-06" version="1">MLRKKPQLFTTMLVGPAGCGKTSFINSLFDQQLVEISDTHKQEAFNVYVSDVDMEGLRRKISIVDTPGLGASMNDSYVHDSIVIYLRKQFCKFLTEETKINRNPNAEDTRVHALIYFIPSRCGGLRLSDIKFLKKVDKLVNLILVIAKADALTLNELKTFKENVKDQVRKNEIRIFNFDKENLNDADVGFELQNKQPFTIISFDSLKPEVTNRVYPWGTPGTMNVDHCDFKILREIILSSYTDVLIEETSEELYENYRTEVLSTLLPNDAVVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV14</accession>
    <name>L7JV14_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sof1-like rRNA processing protein (Contains WD40 repeats)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993979">
        <property type="protein sequence ID" value="ELQ75249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV14"/>
    <dbReference type="STRING" id="72359.L7JV14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1812"/>
    <dbReference type="HOGENOM" id="CLU_123075_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV14"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="8">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="101" mass="12115" checksum="0B368877373213F6" modified="2013-03-06" version="1">MLAVNSVSVYKKRFILSGSEDGNVRLWRLYASEKENMSRREENALECNQMLKDKYYHVGDVRRIDKHRFLPKELKGRIRNEIEHHKAVERKKNRALTKTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV69</accession>
    <name>L7JV69_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative E3 ubiquitin ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV69"/>
    <dbReference type="STRING" id="72359.L7JV69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1912"/>
    <dbReference type="HOGENOM" id="CLU_037459_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV69"/>
    <dbReference type="OMA" id="EYAMNCK"/>
    <dbReference type="OrthoDB" id="2189962at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="277"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="330"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="542" mass="63554" checksum="A4A4B43FF1B1E16A" modified="2013-03-06" version="1">MSPERMAEFEYLLRYVLGSHTLKLMNKKKCAGSQQKQDFYARYKRNDTFCAFFLKKDKNTFVPLFNLPIDFEKTEHTLYYGVIAIGKTIYADKAYSVEFSPPEGFDSFVVYDETLKIISDYEEQPISTENSCEKEDSKIELNELSSDGADENLQIDKFKAQKEFAELLKEYRDIGYDFNDNRENKNLKKMHGQPQESARTNGKTVNNNENVRQCLERLALKGQNEGACKNREDLLVRIVDGNIDIKRFSYVIKDSERILPLYEVEFHFDKNLELQSKKSNMCERCQKREANMFCVAERASFCKECDQKLHYDFFTRRHLRHYFSKLGGSKKFFNCEEHPETVVDYFCKECKIPLCTQCRLKGSHPSDHALITYLQANELVDKLKAEINFTEEEKKNTTCMSLLKVEIDRFRSNVAEVKALLNKQYRAILNELDVFTNKKYQIFNAKYLEVFKENQSLLFTKNFVVSLDNSKIIQNYRTILEQRDALKVKEDPKVKYKSIYLNGTLSLQAVEHSGVPRKKNMSAINKSKEFYAESSESRIDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVB1</accession>
    <name>L7JVB1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1853"/>
    <dbReference type="HOGENOM" id="CLU_1278422_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVB1"/>
    <dbReference type="OMA" id="NGHNIFH"/>
    <dbReference type="OrthoDB" id="10310231at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="216" mass="25181" checksum="5D8A961939E2D186" modified="2013-03-06" version="1">MLFYLLACYCLDLTQQKWLIVSKTNSSAYLQLKDGKFSILKDVFPLNYDDDRVVTFIAKNPADYKRKLERQKIQPTEEPLTENVFFTISFNQGKLCKLNKFKNVAPCDGPSNKESLWRIDENSNGFKIITGDMCLRLTTTDSKLYAKTLSVGLDECDDDPTFYWNIEIMPRNFSLPEDIDEKYQIFVPKHKGKNGEEINGHNIFHYGKYKKHAKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVC1</accession>
    <name>L7JVC1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent flavoprotein reductase</fullName>
            <ecNumber evidence="4">1.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.6.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JH994031">
        <property type="protein sequence ID" value="ELQ74677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVC1"/>
    <dbReference type="FunCoup" id="L7JVC1">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2401"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="InParanoid" id="L7JVC1"/>
    <dbReference type="OMA" id="KPQSECW"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="90"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="421" mass="49935" checksum="46EEFA1675918BB0" modified="2013-03-06" version="1" fragment="single">VRACPTIFLKSCNIAVFGLGDSSYAKFNFASKKLFKVFSKLGANLFVERGNGNVQDDEGYYTALFPWIEKLITNLQSLNIKGAELIIKQKRLYDATIISKNMLTPCDHFQEILEVGLSVENYDDFEPGDTIRIYPSNYNWREFCDYIGNVDDEDHVRNTMDYNFVPFFRIFAEIVKYLEDEPLNDYVFKNPERKEAVIRRIREMSTDYELYFDYVKRPKRTFFEVLQDFALKLPFSFLKKIVPNIQPRYFTLTKRESSYYLTIALVEYQNSIKAKRKGLCSQYLREINVKESIKVGMVKSHLFYDSANLLFICTGTGITLPRAFWNFFTDKNIVVFYGYRHDDKDRLYVEEMKKNKNVKVVYAPSRMGEELYVQEIFYKYFHDSIDQYLIYVSGRTRLNKEVRQMFVKKYGAELYFQAETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVE0</accession>
    <name>L7JVE0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">26S proteasome regulatory complex, subunit RPN9/PSMD13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVE0"/>
    <dbReference type="STRING" id="72359.L7JVE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1692"/>
    <dbReference type="HOGENOM" id="CLU_073111_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVE0"/>
    <dbReference type="OMA" id="KVIATME"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="300" mass="35526" checksum="5FFF2AFA0866D918" modified="2013-03-06" version="1">METLTDLLKQRKWYNAYLYLQAMDRECLTTELIEQFLKTVLPIASQMHPFSLTTTTINITENYPSRFEVLSQLREKINESVLKTDEHAESLTLIDIVLAEIKLERGLNIEESVYGFRNMKLTREQQKHFNRLALKYYEKMRNYNEAYYYAKKQKNIDKMMEYSVFAPNIFNLPVFDDEPEYFRAVREGNYRYIKDCKIDNHEFVLQKTYIIKMLDLCYNKHTVSISELCSNLELERVVVLRLIIKALGLKLIRGAIDGANDSLAVSHIYLQTVTKKELLHMKEQFVKWKARVDKVIATME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVH0</accession>
    <name>L7JVH0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative WD40/YVTN repeat-like-containing domain, Quinonprotein alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994027">
        <property type="protein sequence ID" value="ELQ74727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2330"/>
    <dbReference type="HOGENOM" id="CLU_538151_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVH0"/>
    <dbReference type="OrthoDB" id="10683621at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="507" mass="57307" checksum="62F91FACE70F7B6C" modified="2013-03-06" version="1" fragment="single">VYGCRTGILFYKNILLKISSDAITGIIENNGFVIMCSRDGHVYFLDKVSRIIYRKFIDNVFLEGIYVHNGRIITCGFRSSEFVVYSFITEMSVHVGVRPKKWSFSGSLFSYVRQSATFLTSIDLKSEYINDNCILSNVVIDCSCFFDDFQFLGDFEGNVFVVRNYTPIDRIQLNGEVNDIKATKNGTSIFLYCCTNNSFVYKILFVDGLLLEERSLRLKNRILSIAVDKYVYVSSSNGLVYKLSANLVLLQSSSTDVLNFSVICVNTNILLGGTDGFIRVMNQNLDLIQKLKVHNNTIFKIACRDQKLYTIGDDHTLRITDIACKEVLNKKIVGNSPIIDVRMNADKIYILCKDKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCAIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVI9</accession>
    <name>L7JVI9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVI9"/>
    <dbReference type="FunCoup" id="L7JVI9">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1990"/>
    <dbReference type="HOGENOM" id="CLU_072117_4_0_1"/>
    <dbReference type="InParanoid" id="L7JVI9"/>
    <dbReference type="OMA" id="STHYTHF"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="155" mass="17765" checksum="7ACF00A8C8BA4811" modified="2013-03-06" version="1">MATDSGPNPATDKPSGLSQNVAWTVHKGSFIAHISVVMIGHSILRFAFTKEIAYQLTPLLYNVLTFVFFHLIVGDPFDPRFNNHSFWEQMVEQIGYSSTTIFFMVFPIVMFIVINHLVVWNVYLFYLTILSLILVVVPKLGFMHRKRVFGLGHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVJ9</accession>
    <name>L7JVJ9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVJ9"/>
    <dbReference type="FunCoup" id="L7JVJ9">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2000"/>
    <dbReference type="HOGENOM" id="CLU_013368_1_2_1"/>
    <dbReference type="InParanoid" id="L7JVJ9"/>
    <dbReference type="OMA" id="KLYPCRL"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="7">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="261" mass="30163" checksum="24D1381E4A5230C2" modified="2013-03-06" version="1">MSFTNTKKIASPLFMATIESFGCKHYRRKCLIITDCCKRTYPCRLCHDHNEDHRMIRHRTKYMLCLCCGMIQGASQFCIMCKVKMANYFCKTCKFWTDSLGVFHCKQCKVCRVGNKNAFFHCSDCNACLPRELLNNHNHVENTLKSTCPICAEFMFESVNDVVLLNCGHSIHFACFKVYKESSFQCPVCLKSAGNTKVLNERIDCILNSNVNLNAKRQNYMCQVSCFDCQSVSKTIYTFLYNKCVKCGSYNTRINELYKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVP0</accession>
    <name>L7JVP0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1481"/>
    <dbReference type="HOGENOM" id="CLU_3335899_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVP0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="38" mass="4386" checksum="61B91B79A9B65D55" modified="2013-03-06" version="1">MIGQLCYTVDVKECMRRSMQLDGEKILVPLQIISNTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVP8</accession>
    <name>L7JVP8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVP8"/>
    <dbReference type="STRING" id="72359.L7JVP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1544"/>
    <dbReference type="HOGENOM" id="CLU_689279_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVP8"/>
    <dbReference type="OMA" id="QEHILMD"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="399" mass="44687" checksum="A65155CC732A1AA2" modified="2013-03-06" version="1">MYRRFFELHDLMKKEYESILTENTQLKKRLREIEDKQEHILMDLDKSRHCIRDMQNYIASLRRMPEKHGAERPAERDRGVERKDMPCLKMGHDWVVEGVPLINVSLLHSFNLGCVPAMVVLSDNQRFLGFTTDLCSYVIRLEDRSMHQLSNASQSIERVPFDAPNGASRELGTLVAICENAMYTYESDSVLRKWSLDTFKLESASGPEKLCAMQQRDNELYVMGSTFVKRVQDGHAVHGVSNAEDRQLCMATCKHKGGMLIFTGTHLGKVLCYDMSTGSVREHAIHTKDVLSVAVSACSSYLVTGSADETIFLLKVQSDTLSVVFGPVSFGDTVVNVCFLDAFVIASGTDNVVRFFDKEMKSVERLVGHGEPVHSVGVVGGMMVSASGDGRVRIWSVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVQ7</accession>
    <name>L7JVQ7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVQ7"/>
    <dbReference type="FunCoup" id="L7JVQ7">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1955"/>
    <dbReference type="HOGENOM" id="CLU_503614_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVQ7"/>
    <dbReference type="OMA" id="CERMFCF"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="241"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="541" mass="62278" checksum="0ECB52113A5DC9F5" modified="2013-03-06" version="1">MEGCSHLTSYKKHKEKYLKIVGCKKRLMCTVCGSRFNIHMCLVCERMFCFPDHLAHDCGVDKEREECVDDRIKINGGKHVMDVKRSVKGGEKLAVNSVNMGNGTESNGNEKGDDLLVLDDIEATIDEDVENEIKECVESDTTNDKVADENGKSMAMTVINTSIELANKFTDKRSIDGQDASKRARTAGSCVLFVNKRYGCVYCIECQKYLFFTKLLEIFVNIKYRIKNQKNYLRMHCSYPKGIINLGNTCYINSILQVFFNTGILKKCFFDTMHEKVLCKNEKCIVCALKNMYMECYNLHSLIVPNEFLYILWSISSVHYSSRQFDAHEFFLDLCELLHKNFFTDPDRQVLGNENTVVKCKCVIHRVFCGVLNSTLTCLKCGCKSVKEENFYSISIGIRNQKSVNDALAHFFTEESLGESVLCQHCERKEPFLKEMSVASQPPILVLHLKRFQMNKNDAVKDNTVLNFSHLVECCTLKSNDSRVYRLFGMVCHVGTLEYGHYFTFLRVENTWKRFDDERITDANENDMCDCSPYILFYELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVR1</accession>
    <name>L7JVR1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LRR containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993942">
        <property type="protein sequence ID" value="ELQ75568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1472"/>
    <dbReference type="HOGENOM" id="CLU_425252_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVR1"/>
    <dbReference type="OrthoDB" id="10321360at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978848" description="LRR containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="73936" checksum="9B18033B0CA029E8" modified="2013-03-06" version="1">MNKFLLFILAEILYCAYSLDQAETQNPSHSEISSISHYDQEQTVKIVEMVQRILNENGCTGLLQFLRAAAYQSFRATFMTVASNSIMFVINNEDFNLQFVHSDNELRGAKNTHLLKININIDLSALGSCVKLFNIFNFGYMKAVVKTHTGIQEYLPQLLTLFNHIIKLDLEVDHITDETMQKLSTLKLRQFYIGVAELKLDDLRNLLNFEFLVMKIIADNLQIDSLSRITLIVMNKVCRKCVIKIQGHSYDRPQGAFMVTELSGQQNVVKIILDNLSSPSINCSFGLELNSMLFHPICVVRSNVEQLTLKFENELYVNELLWCCVGLKILNLQFKRIVNGFSFMRSKNLYLTLEEFKISVKEDVNCNAQMLNEALHHFECLINVDIRIKFSDSSSENVFNESLITSLESLTIDSNALDENFFKHAMEFYELENVDINRPTNTTTVHTMTMLSDLTALPALTNLSLDRVSNTHEWQILENCRGLLSLEIKTSIDFPLITSTDSQFYRTLENLSISLDICIIQHVRLTFVKLTYLSLEVTSENSNLSVNDSAVHCFMQANFDGGINETLATLILRQNTSFDLTLLSTFTFPALTCMCLEVFDPYERGYDEQFGRNFYSHISGRFVLLKRLHFIFKCSQRHLVFEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW46</accession>
    <name>L7JW46_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1757"/>
    <dbReference type="HOGENOM" id="CLU_3193993_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW46"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5222" checksum="90DCD5280F13ADE0" modified="2013-03-06" version="1" fragment="single">VDRKVSLMITSNYKALLVDNDVFDTESMHLIDNVCHIISKIADDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW70</accession>
    <name>L7JW70_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW70"/>
    <dbReference type="FunCoup" id="L7JW70">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2049"/>
    <dbReference type="HOGENOM" id="CLU_037460_3_1_1"/>
    <dbReference type="InParanoid" id="L7JW70"/>
    <dbReference type="OMA" id="HEVCLEW"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="287" mass="32147" checksum="DF13C4E7FE02935F" modified="2013-03-06" version="1">MAHKPTKTFLIVGMAGTGKSTFSQALYTWISAKYPPIIDPQSCLNTNITAINLDPATLKVKMPLDLDIREYFDYENVMQTYNIGPNGAVTTIINLFLMRWDVKITGDFVIIDTPGQIEAFVWSNAGKVLVEKLEHCRSGISDERGDNSVSDTPANDGNDRLGSGTAGTNPNSVILLYLVDSMECRKPSVFMCNMVYALILRLRFNIPILIVFNKVDLSPVPVEWLTDYEKFMDDVNDDTMCNSLLGSMALYFEEYYRSFNYVGVSSVTGAGRDAFFERIERIVDESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW71</accession>
    <name>L7JW71_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription initiation factor TFIIIB, Brf1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993942">
        <property type="protein sequence ID" value="ELQ75570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW71"/>
    <dbReference type="FunCoup" id="L7JW71">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1474"/>
    <dbReference type="HOGENOM" id="CLU_010293_3_0_1"/>
    <dbReference type="InParanoid" id="L7JW71"/>
    <dbReference type="OMA" id="ISMAHRY"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="191"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="429" mass="48947" checksum="A354D6597295CCAD" modified="2013-03-06" version="1" fragment="single">VSAPVPEDKIIRRNPSVMDVQKCKTCGSTDIDDGHSTSNICCRKCGTLNEELFITSSLNFTENNGSSQLNGQFVRITDTYAKVGGNIIRTTNLQIQNQIKNICGSLGLSDEVAQSAYRWYKLSLQGNLTRGRNILYTLSACIYIVCRQEKTPHLLIDFAQLLDLDVFKIGNIFMRIVVFLNVKVPLIDPSLFLHRFFSKLKLKNGKILLFAMRLISRMKRDWIVVGRRPNNLCGAALVTASRVYAEERSVLEVAKAVKVSPHTINIRLKEMCDTQSANLTVNDFFNVWLEKEEDPPISKYKLKMVDDKTIESGMLTPTSDVSEKDALVFDEQFLATYDHNDTEDSIDSEELECFILTKEEAKQKEKVWDAMYDGFLRERAVRGSTRRKEHKKRKPRVVYETVEDALKGVIKEKKMTNKINYEALKGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWB0</accession>
    <name>L7JWB0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1361"/>
    <dbReference type="HOGENOM" id="CLU_1603908_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWB0"/>
    <dbReference type="OMA" id="IFHSEAF"/>
    <dbReference type="OrthoDB" id="10297679at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="166" mass="19020" checksum="692665F53D07E8A1" modified="2013-03-06" version="1">MFFIHFLPLILCESDEQPKDNPIQNIAFDKSRKTDGYEAILFFKRDVNPSQISIMGSETPDDDESYTIVKVMDIDSDFEETRNRLHVPLDDDVLMQKGKTYSIQIREDNEIFHSEAFQFDKSSGKFKLSREMKSTGGTKAGWIVGLVLGATALFLVLILIFVRLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWD5</accession>
    <name>L7JWD5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1991"/>
    <dbReference type="HOGENOM" id="CLU_344236_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWD5"/>
    <dbReference type="OMA" id="LHTFIAY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="822" mass="95919" checksum="997561C559887F6A" modified="2013-03-06" version="1">MPTITHSVLHTFIAYLSTPNTTEKQARIERMRKKLAQRKTVDRLYLQQNLYMSINNDVTDAFVFINACQHTDRRIKFLGYTGALQIRNKDELLMMVNTLKKDMDRGDVLAVRYLANALEVPVEDIRNEIRFECTREMLVLFYKLYRMDRMAKNRKNAFDDGETDKNDTENTWMDDTATYTKHNKTQKADPQSNYQGDQAKIETKIINIDRTNGPDKTVERVAEHCLVDGNKAEHMVNEQETAIKIQKCVTGKEIPRNALNVLRNNFGKYNTLNRVKQITVKMPHRPPISLQPTTIRALSDGSIHHSDFKRFYSLKIQPDDLLDDILFIKLQIMLDLDGDIKLSQTEQAFLLTLFKESGDNILRTKILQVVTRTTNIKKNKDWTGEISSRLKFPGIYKMGADQVAVVLECLRFMVRHGVAIPDVNVFLYRLLHSYQNNFVFFALDVLRTYRVFDKQVIDKCLKMETVDHLAYDTLLGNISKKTARFAFKKIEKTLMLFSNDENVQKIIKKIIDKGSDRLLVSIIKNYPNLGYFYNILHKVKDKTKLKAVRDFLNTNLNVYGVDLMCQLFEMNIGFDLTRRKTRYYDTTEDDEEMYEELVHTDENKNKMVDYEIICSNQDNNEQINASKSTTGITNGNRGSQSTYTYVSHIDDFESSQNGIIEFSDETASCTDETYERAINNEPTRNSLLEHRNKLMTEFLMDDLSEKVSHVFTSDREEKKENYINEKKKTSNPTDIFENTNFNRINRKYTTFYKKGLKVIAQTMDQERLKVLDHLISVCLRYGNVRSNKELLIRFLRKTNDREIRGMIEKGIEYFELIGITSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWH6</accession>
    <name>L7JWH6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="8" type="ORF">THOM_1297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWH6"/>
    <dbReference type="FunCoup" id="L7JWH6">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1297"/>
    <dbReference type="HOGENOM" id="CLU_035060_4_2_1"/>
    <dbReference type="InParanoid" id="L7JWH6"/>
    <dbReference type="OMA" id="DCSWESA"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="174" mass="19895" checksum="D3B9B577AAA1B293" modified="2013-03-06" version="1">MIRKIIYDIGQCNRKICSGQKLIRANKVVMLDNKHRFGGILLSPKGTQTISPIDKLLIEKQGIGLIDCSWKKVDSTDFKLFNRCKNRLLPFLVAANPVNYGKACQLNCVEALAAGLYICGFVDEAYNIIEEFSYGNEFLKINYELLSLYKDSRDSADVIEKQNKYLKDNMRQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWH8</accession>
    <name>L7JWH8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993919">
        <property type="protein sequence ID" value="ELQ75828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWH8"/>
    <dbReference type="STRING" id="72359.L7JWH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1221"/>
    <dbReference type="HOGENOM" id="CLU_539900_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWH8"/>
    <dbReference type="OMA" id="MACPCIP"/>
    <dbReference type="OrthoDB" id="5278208at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="505" mass="53517" checksum="84B0ACFCC670302E" modified="2013-03-06" version="1">MLIYILLTYQSQHTLSPISHPNKYLSLTNNVPTFSDCAYPIQLTDHNGILLSNSQLCANGENVTIHCTDKNVTNFKVENTNKYVMLKSDGKCLTIVRMIDRYLPMLDECNFLDSQLFVVGDGSGMCVGEEGRIGEPVIAYGDDRGVRYYEDGGMMIDCDNLDEAMREKYKDRCKVIGKGVGGNMGSNVGSNTGSNMGGSSGAGNNVGGNANINANVNANVNANLSTNLNTGVNNPNGINTSGNGTGNTTVNNASSVTAGQGNATIPITTLNASTPPQNVQPPVPLQQPSYTQLLPVQPTAMVTLSPVTTPSANRPGQIQQNRPNECVSPCVFRIEVDGRGVCICYNSANTYGNTSNINAPGSINPTGGINAPGGINPTGGINAPGSINPTGGINTPATNTTSALPASVNVSQTNGTMPTNPAQSPPFQLPISPSNTNIQSFKIPTIYLDEDTFKSLKMSTPSPSFHTQCCNTMACPCIPIINVYPIINLDVEGLFRRLKDRMKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWQ3</accession>
    <name>L7JWQ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein PSP1 (Suppressor of DNA polymerase alpha mutations )</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993904">
        <property type="protein sequence ID" value="ELQ75913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1121"/>
    <dbReference type="HOGENOM" id="CLU_080493_1_0_1"/>
    <dbReference type="InParanoid" id="L7JWQ3"/>
    <dbReference type="OMA" id="EYKIRIW"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="218" mass="25729" checksum="D85969E982244199" modified="2013-03-06" version="1">MKSSFFFIHVNDPWQFTSASWLEKEYRIVGTAPFSPKKEPSTTAELIESLNEVIYLIEFNSGRMNIGYSDDPYSIGESVILEADRGMDCGVVVAKVKKKKYVSLIYRIDKNLSNKELHPKKIFRRAGENDLKIIDLKTRKERIALADCRTRVKAEMLNMVIDKCEYQWDMNKLTFFFSSEYKIDFRELVKNLYKEYKIRIWMCAIGKSRNHHLRELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWR7</accession>
    <name>L7JWR7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1892"/>
    <dbReference type="HOGENOM" id="CLU_3224896_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWR7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5234" checksum="84350F2B2FF9EEBD" modified="2013-03-06" version="1">MFLFNFIFFFEGSKIFCVMNDRFHEPTVVETMVGAQRARRVCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWS0</accession>
    <name>L7JWS0_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993902">
        <property type="protein sequence ID" value="ELQ75928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1115"/>
    <dbReference type="HOGENOM" id="CLU_1125202_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWS0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="247" mass="28443" checksum="542669404D09056A" modified="2013-03-06" version="1">MQNMSVKKAKTQRCALGIFDRRNLAMNDDFEFIVEKLCKSVKLVNVNGLTRFAAFGAIKCFEKTVLIYDWHSKGKFSEFTMVNARCESDFTCAEDIDVLTLDHVDVISTFVMCFKGTCGSILLSCCTGTIDLRQINKESNIRCSYLITMDFFTRLPVVIRSLIIEHITINHNIEITNKIYSLEINEVAVNNPFSLTLCEECDEIIIKKSSGRIDLFKKLHLMIYSRERKYQKFTLKKITTLNHMILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWS8</accession>
    <name>L7JWS8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993907">
        <property type="protein sequence ID" value="ELQ75884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1148"/>
    <dbReference type="HOGENOM" id="CLU_2596798_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWS8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="80" mass="9744" checksum="061712072F42FA53" modified="2013-03-06" version="1" fragment="single">VSVYIDMPHLNDKEDIKTHRLKQHLTRNMESIIRLSLFFDDSIYYISEIYDNLYYDVKIGPKWKDARINKVVKNYTKYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWY2</accession>
    <name>L7JWY2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1855"/>
    <dbReference type="HOGENOM" id="CLU_874886_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWY2"/>
    <dbReference type="OMA" id="NSFYCCT"/>
    <dbReference type="OrthoDB" id="10357877at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="318" mass="37488" checksum="72E90436B634829F" modified="2013-03-06" version="1">MFIERLYTFRHNHRINHVFESRKFILVADSTRVYFWDKKTKELRKTKTYNVEIFTIHKLMKVNYDILAKYIRCKNGENKRRKFIFQSFKRIFNDEISIKTKSLTKACFNGAVIIGNENRININGTSIKHKYGNIIGIQSLHGHFFASFEIGKICGIQKNYLYEILNIDDVPVSFSWDQNSFYCCTLSGFLYKMKFTASNFVNIAQAAQKIFEDKEITNIEMCDISREGITEQHYNMEELKIKTLMVLDKYTDIGRKIKKIITKDNTVIIHTVCDNLVFLNQNLEIEGFLENVDDVFDRKEGVFVVNGYDVTELEWGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX06</accession>
    <name>L7JX06_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative small molecule transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX06"/>
    <dbReference type="FunCoup" id="L7JX06">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1207"/>
    <dbReference type="HOGENOM" id="CLU_019324_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX06"/>
    <dbReference type="OMA" id="HECYESD"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="402"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="605" mass="70901" checksum="3D3664163D630F5F" modified="2013-03-06" version="1">MPRPRSTQLPIPRPRSTQLPIPRPRPTQQERQRQKQQEQRQEQEQRNKSALLRVKPIVPKTKQKTRRIAAVRRQSAYNEVNYDYITEDQEFETSHELEENDALPRTHTFLNLGLIKLHYTVHKKKRATMEFIKVLNQIINYQRINYALLEHCIAKRRTSRRVKRNELQPLIKQSYFYRSKEAAVLLKDVKRLYRQRFVKNDKNAGRLFRRLRRRDRPKAVCVFASGVLITVNAFFMFSGVACREGVCALLPFLRGAQCSAAYDPYTPQLFFSLLFVGFYLFGVSLLIFTWKKINHPFIFSFNLDSHMEVSRYFVCTAALHLLYNAINALPIDAKASFALAMCAVGACIVLPLDVLYRKSRYYVVYCVLKIVCTPAFKVRFRHFFFTDYLQSFAIVYRKVLGCFFTLGPVSVFFIGNYGNLVRVMQCGRRYYDKPERVHIYNAGKYVCQIMFSILTITYVHVQDGRTAHKNARILFVLKYLRLVVGILASSFSFVWDVRVDWGLGRKNLLFAKSTLAVLIVFNLVGRYLWLLSAYLSDFFVCVYEIVRRTNWGIVRVEYEHLNNCDQLKTTSTIKLSGDLFYRKNKRAEDMSGHESTHDEKEESMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX27</accession>
    <name>L7JX27_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1469"/>
    <dbReference type="HOGENOM" id="CLU_752688_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX27"/>
    <dbReference type="OMA" id="CATSLHI"/>
    <dbReference type="OrthoDB" id="2201101at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="368" mass="43586" checksum="C698849712DFFB1C" modified="2013-03-06" version="1">MKSRETYHNLAKEYNNIVRKNTMKGYIKKMKTVFKAFYIAKDDVKTKSAIYQFFDLIRESISEKNYADPVNIDRIITNDISKLCSIFMRFKYTGFNLSMQRPNPSQCLMKLCATSLHILHETRVREKHIIFPEFHCLYEYFQKSHVVKSQIVNFTKVFIIYVVSKIETVISTVIALRNEIAKTQNNNEERTHNMTLYRFYAREALISAYFLSIGVRRYSVRNYILLSRLEYSYLCMNPLSCSETPDIKSINPYNVSFLLFATFDLRFDFYNLKSSKRANGIITLSYINENGMLNEMFYYDLNIFKAVLKENITKLFDPRISRLAQFGRLLNVIYHQIDSLSSENLSSTMHKIHVIYKFVRYHLLVNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX87</accession>
    <name>L7JX87_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing subunit of the 18S rRNA processing complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993887">
        <property type="protein sequence ID" value="ELQ76044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JX87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0995"/>
    <dbReference type="HOGENOM" id="CLU_555020_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX87"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="492" mass="56412" checksum="800F5F225EFE881D" modified="2013-03-06" version="1" fragment="single">VMENAAHKMVFLCYHRNEILQVKLYGDVLFSVSVDKLIKWKITENERIEDGKEIVLVNSRDLQVNAVGMCLIGGSVVLADCEGISLYNMHTLELVETRAMENICAVSSCDHFVAIARNNELLVVDGSLRTRWCITDESEIVFVRFSRDEQLVGVSNYNNKINIYKLRTMELVMSLYGHSLPVRCFDFSNDGRSVISCSADKLVKLWGTEFGECRKTFYINSSMVMFMKHSKDLFLAADNDIHCYRKTECVKRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKNFDIKLFDYNDDYLVAAGRYSVYLYEMDRYELVKDSSSESEEELEIENLKVYDKFSRALEKSKEDADYDALFNAMKELDMGDISSIISGLDNNSLYVVLQALKNNIDYNVVLAVKVFFSIVEHHRYFVAENQSAYVVYKEIRGRVELLRQLIKENEYKIGISNSIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXK7</accession>
    <name>L7JXK7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXK7"/>
    <dbReference type="FunCoup" id="L7JXK7">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1242"/>
    <dbReference type="HOGENOM" id="CLU_047877_2_2_1"/>
    <dbReference type="InParanoid" id="L7JXK7"/>
    <dbReference type="OMA" id="SGYKFVH"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="196" mass="22633" checksum="38CEB44A0706B035" modified="2013-03-06" version="1">MDTLGQNALNAGKSYVNTRIHTLSPSILRPYFKVTPNHVLSRIILLLFPFKTSRWTLFSPDLYVPFVSYQSFLLVKALCIKNNKLFAYYFTKTLVIEVLLIVFVKALSFFMDVEIMVINLVAVSFHKYIVMVAGLLCGSFNLFVGRLAWMYLVVAMFVFFCRGFKYVIGSCGVRRKSVYFLMFVVVLECFYVLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXL9</accession>
    <name>L7JXL9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993883">
        <property type="protein sequence ID" value="ELQ76070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0958"/>
    <dbReference type="HOGENOM" id="CLU_2326496_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXL9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="99" mass="11644" checksum="2E8F908A268AC55A" modified="2013-03-06" version="1" fragment="single">VIEHYQHSMPHTKLKPLDEVIEMTDLANIDARDIMYELKNQREKLEGIESKNRITKGLLRSADELSNKIFRRKRIIGVVMVMMVIFIVVSYVIYKIRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXS5</accession>
    <name>L7JXS5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-6-phosphate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.1.1.49" evidence="1"/>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0769"/>
    <dbReference type="HOGENOM" id="CLU_1541190_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXS5"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="174" mass="20294" checksum="CCC4315AE3850F3B" modified="2013-03-06" version="1">MVFTHLFNVYEHIFGNGSLKGLTFKNLHLKGQYNGYEFKGSNTETFSFSVFEHKSGYNVLFIAGKGLKAKKTTVEVLRTADNVVFDIYPNKNVVWRDEVLVNAEAVEEYVKRTHVYDDYDLVLRSLIVEKELYTVPVERIKETYRLLDEINALHTSLFFYDQGVELPEQVYNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXV0</accession>
    <name>L7JXV0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA replication licensing factor, MCM3 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXV0"/>
    <dbReference type="FunCoup" id="L7JXV0">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0800"/>
    <dbReference type="HOGENOM" id="CLU_000995_6_0_1"/>
    <dbReference type="InParanoid" id="L7JXV0"/>
    <dbReference type="OMA" id="EANHIMV"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="5">
        <location>
            <begin position="282"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="671" mass="75858" checksum="F15C0F0D1BA4DD44" modified="2013-03-06" version="1">MADFFVPSLKKYVEEKITGPIRTDERITFSLNDIRRKDRELSAKIVEDPISFIPFVEHEMRVKFAFTGSFGEYQHTPSSITSDFLGKMVKVEGIITSLSNIKPKLRKSVHEQHNTFYSKEYRDATTLSALPLTNTVIPQTLKNEPLNFEYGLSTYIDTQTATIQEMPENTKPGAMPRSMNVILYDDLTDSLKPGDRVVLTGVYKTYCYNNTSFPNYLPTALIVNHVENKNIKRIFEERLKKATHEYTAQISEEDGISNQEIGGIGGDQTSNVDFIAVRNTITSENALEYVAPFIFISPLIKKAILLQMIGSENEVCRKSINLLLLGDPSTAKSQILRFVINTMNAISTSGKGSTGVGLTASIVSDKNERRLEAGAMVLADNSIICIDEFDKINYNDSVVLHEVMEQQSISINKAGIHVTLNARTAVLAAANPVYGNFVDDSLEKQVKIPESLLSRFDLIFLIVDDGSFDSQIADQVLCNHSSSSDLQDDRVFELRRFIFECKKYKPRMRKECAHLIIDYYVELRRSKTRFPVTPRLLDSLIRLSNANARFRQSDTIDEIDVKEAITMVEHCYTIPKGSQFKRMKVDKYDTEMSIDIENTRNAVTSEVSDATALIKEVISKYREENPDSSFLSLNDVAARCELPLEEITRILTELDAEDIIMFKGETIIFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXY7</accession>
    <name>L7JXY7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXY7"/>
    <dbReference type="STRING" id="72359.L7JXY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0704"/>
    <dbReference type="HOGENOM" id="CLU_593394_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXY7"/>
    <dbReference type="OMA" id="LMHAYLH"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="289"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="459" mass="53216" checksum="715C1B88E2E230BB" modified="2013-03-06" version="1" fragment="single">VYTDKTLNFLPIMIIDLCSALLHKLNKNLEQLNNGQPIPTHLYSALHQQICRINTFNEDLLMARIDKIYKSLNSSVIVPPALVKLYHDDKHVGNDAPAGTLVGLIGQNIVKPLVEDVELHVNYECTCDVSEIPAELRVFDENMTWIDETNKESFLESLKVCKHVLMHAYLHTYRTYQPFTCIFLVKTHHGTYLIDTLKHKRMVARLSYECTYYKYMNGRTLHALKEEFKVVPCCCSLVKTRECYFVDFRIRPIHDDLLRLEVTHEKDAEASSEGVQQVVERMSAQNNVTGRERKVLEDILKLRDFVAKSNNESVNYVLTERQLCLILENMPKTKMQFKNVLPRCSPILRAHIEDILFILNESVEDSTRSYKEADDGGSSTVEHKNVTESKSRNGNSGHPQKDNQNEQRLNDRLKQIDIKSRSVNHLDIDSSIAKVRYNTFDYDENVVEKVKNKFRRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY55</accession>
    <name>L7JY55_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993850">
        <property type="protein sequence ID" value="ELQ76403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0616"/>
    <dbReference type="HOGENOM" id="CLU_2529067_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY55"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="84" mass="10149" checksum="AF99DCAEB955B2B9" modified="2013-03-06" version="1">MHLNRRLHDYYKLSRGSEQIIVGRFFKWIKSDIQYSPDNKSDVLYLKLRKDFSSNILKLSVSSDIMKRLASIKFKREVYFLLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY76</accession>
    <name>L7JY76_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY76"/>
    <dbReference type="FunCoup" id="L7JY76">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1344"/>
    <dbReference type="HOGENOM" id="CLU_033449_2_2_1"/>
    <dbReference type="InParanoid" id="L7JY76"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="196"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="345" mass="38622" checksum="92D3C9C226A77311" modified="2013-03-06" version="1">MELYRIGIIGSGSFGTAIANIIARDVQNKSVFDDTVKIWIFDEQVRIDGSKELLSEYIKRERENVNYLPHVKLPENLLFMTNLKEVVQKSDILVFVVPHQFIEKIVQDLKSMKLKKKIACSLMKGTLFSEETAEIVLISNYIEKELGWPCSAVMGANIASEMHKSVCEMTIGSRTDGDLLKQLFNTPQVKVNVVRDKTSVELFGALKNIVAIAFGVARGLQLSINTQVSIMRRGMLEMIEFVKMVDKNADKLTILESCGIADLMVSCITGRNAGCGTAIASKGLTIEKIEEDMKGQKLQGTLCAYEVMMYLRKKNVVDKFPVFATVYGICYGKMDSNQILKVFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY78</accession>
    <name>L7JY78_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA replication licensing factor, MCM6 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993848">
        <property type="protein sequence ID" value="ELQ76428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY78"/>
    <dbReference type="STRING" id="72359.L7JY78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0589"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="L7JY78"/>
    <dbReference type="OMA" id="ISDSMCE"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22247">
        <property type="entry name" value="MCM8_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056875">
        <property type="entry name" value="MCM8/REC_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25051">
        <property type="entry name" value="WHD_MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="346" mass="39428" checksum="81CA86F1A7E426DB" modified="2013-03-06" version="1">MLLNACSLLPKSTFVCGNSATTAGLTVSLTHDPVSNDYVADAGALVISDNGLCCIDEFDKLENPTSLLEVMEDQMVSVAKGGVVCKVPARTTIIAAANPKFGHYDASKKIKENIRFKQQVISRFDLVYLLRENVNEDYNVSENIIKKFRKEKKEAEESRKYGVNLVGAEIKDDLIDFVRNDSLSHLLRVAPTIYEQELLKKYILYARNVVNPVLTAEAKTKLQNYYVRLRKNENITIRDLESLMRLTEAKAKMELRNIASKKDAEIIIQLYEKTLFKEREQTIKKVDLLEYLKDISAQGQNIFSTHELNSFIERLGLKKPAEQIISNMNNQGYLIKKGKNQYEFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY96</accession>
    <name>L7JY96_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor of the Forkhead/HNF3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY96"/>
    <dbReference type="STRING" id="72359.L7JY96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1369"/>
    <dbReference type="HOGENOM" id="CLU_103809_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY96"/>
    <dbReference type="OMA" id="YHFISTN"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="200" mass="22823" checksum="4FD0F6614A8ACD90" modified="2013-03-06" version="1">MSTSKNIDTGRRTGRKKNISYAALIAQALLSSANNRLTLKEIYHFISTNYPEYTLHKQGWQNSIRHNLSLNKAFYKEPKIKGTPGKGSHWSIDLKAAKNILDKSDRSIRTASRIRRGYGHTNSCLNRKRSPLLGDIRISDEKKKGAHKTIIFNGDLNPYNESLEAFFGLPNHRDDENGDDGGKDRNDWQNYCGVNSYFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY97</accession>
    <name>L7JY97_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">20S proteasome, regulatory subunit beta type PSMB2/PRE1</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JY97">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1029"/>
    <dbReference type="HOGENOM" id="CLU_951767_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY97"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="293" mass="33760" checksum="36DB35DEB3466B36" modified="2013-03-06" version="1" fragment="single">VQCDKIQRLNYHVQLQNSKSERLNYHCLIQNSKSERLNYHVLLQNSISERXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMDNLIGIKTKNFVLIASDMVVPSSILCIKSDESKFTSIYDTVVLAHCGSFQQCCDLRNFFTETIKLKTLDEQVPLCPQTAAFFIQKVIHGQLRAQPMESAFMVMGKDGSLYAVDQYGALSTSNYMCMGYSRFFLYGLLDKEYREDMSVDEAVNVLQKCIDLMKSRFLFNYQRYMVKIFENDRLRSVELRPSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYG3</accession>
    <name>L7JYG3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0662"/>
    <dbReference type="HOGENOM" id="CLU_1090654_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYG3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978982" description="EF-hand domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29637" checksum="3CFBE6860FB11E33" modified="2013-03-06" version="1">MQFGVLLLAVLISATDELFQWMKIEENLPYNSRDDSYESDGNGYVSKDDFLEPKYKFFERKHELDENFKKLCKPDIMYMLKEGEKAMICDFLEAEVIRSKVDGELDVNASECLLSFFEDVSSNLTKGIVDYKIFVYIFKRVNHNLGKFTNVRMLELPADIQLQSYSPAELKENIENVISQSIDVRNTFLEVLREMLGEVEKVLFCRTGRKITHTSGLYIGMMMKTKRKRMLLLCGLRVSKKRLKSSSVNMSQIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYI4</accession>
    <name>L7JYI4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0683"/>
    <dbReference type="HOGENOM" id="CLU_286547_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYI4"/>
    <dbReference type="OMA" id="PEEIFMS"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1078" mass="123763" checksum="AC249B5EC583E809" modified="2013-03-06" version="1">MQITFKITNNAAHSNHLNFRFRTPIKRILRFQKYIAVLSDDLYLYSRKETFYIKNVVYIDDTYFYIREGKKIYRLTQYYGQREEVCMKDGCSSDEMVMATRGVSVDELVYRNYTRVGDSREDGTELVGIYDRHFVLKKGARVFYRQRVFDAVLAHLYRTYLVLAHEGAVSFVDLETFNSHQISYRVTHGIRTKCLNCDTFLKIDDMVVYGRTVVSNNYRRVVIRDLMHELIARAKDRENAYRFVYLDSLNFEALNAQFDMHFERCRGMAVQDFRGLLQKVLSSDLECFEGGFVQFVKSQGMDLKGITQNVILKRGVRRVFDEIFLIMVFYKITGDEFFFNLMRLRFLYDVGDEGGSSVVGHAFSPDGLVTGPLVSSPEQSVTGSASVSSAKLVGPALVSSPEQPVTGPTTVSSAKLQASVNNIKPVTGHPSNKIHENKHKTKERHTKGPSKDALTAKNVSKEKLNVHYERLFFYDRSVRIDGMVKKHRAQKDVESIKKILYESKIRFDAEDLEGKRKDAQNIRRHASLGDALVFFLSRRMGRKRLSDKLMNRNITKLNDVRALLAKRTYPLLSVLLADHVNKLREKSERRGPYSKGRRKFYDFYYRLVHTIKYSEMICTYTPMSDPFLELVLNGFMFMNTEKQWVKRKLHRKDDCKPEEIFMSEVLKGCIDFEEVDLNGLVVVKDNQSNGYYYRVAGRLFYVCLWFVNYCDRINKKAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXACKGRLQQKALNYDVKIEYFLNMSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYM9</accession>
    <name>L7JYM9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SNARE protein Syntaxin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993917">
        <property type="protein sequence ID" value="ELQ75847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1199"/>
    <dbReference type="HOGENOM" id="CLU_2948397_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYM9"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="7062" checksum="486050903D8CF7C7" modified="2013-03-06" version="1" fragment="single">VVYYSAVYHNKQKIEKCLLSMRDGLLQLEERHFKIKEPERYLQSIKKCFLAVCACIKAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYP2</accession>
    <name>L7JYP2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993838">
        <property type="protein sequence ID" value="ELQ76554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0467"/>
    <dbReference type="HOGENOM" id="CLU_3070359_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYP2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="53" mass="6060" checksum="12C7EF540DA0DCE5" modified="2013-03-06" version="1">MSECDTAEEPESSNIIDVDLGIIVEENKDCNKNIYTRTQHTTCLCIKKLRKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYW4</accession>
    <name>L7JYW4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0340"/>
    <dbReference type="HOGENOM" id="CLU_343294_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYW4"/>
    <dbReference type="OMA" id="YFINDNC"/>
    <dbReference type="OrthoDB" id="10364799at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="827" mass="96352" checksum="3B4EB028DDBF65E8" modified="2013-03-06" version="1">MHIKAFKMDMKPRRFLFINHTLYLLTHSAIHIIDFKGDIKPDISLENVTLNESKREVITGDENEMKVMNQNNERNVTNGKKILERAINIDVKDVLVVKQYVLVQSVDNDMYYVKAGKTGLTRYCMKVEKIVYNEKIYFINDNCIFETSVTKLREYPKVVLVFPGKIENLEILDGRLLFFASRKVFLAEKTNLYYDNYISSVNSNDNFTANSNAKESDYRSSKKLCRAFNFVEIGALSELQFVYTANNKRFVLLTTIDSIIVLSYNTETVVLKKPDELHHILLVDSYILIFSHKILIYSAIDGLPIKEIALTAFNAVYDEVSDCLVMYNGVLFCASMSELINGTDGEIEQICSPGDIEQNNRKFIRDPLNCDKYVDKKKNISVAKHLTADEEANSGVPTNFFTNDQTKDLNRDMPKEYFECDEKTLITENDAMNSNTTVEEENDLYEETNIQKESNFDALIKHKLFKFAYPINPKQTFLHYSRCAYKSQNVLKALFFYAQTTKKYAFDRSNVIELCQQKNKIDLMTYKVALKCDIANNMRVTVGDLIYFLCIRSVFMNKETNYLFYLFCILEMKKHQRNLLRFAIENEIRIKLLERIDIYELIKEKIEQKTVGKEQQIRSEESNELLAQEENVKYSTSAEFLSFKPLSEHISTEHRENRSLITKHLSKKLVVQYWKIYKPEKAVIYYFVTEKYEKCARLLLKTHLKIPQLQSLLLKIQLFTKVANVSVLKLYDVYFPDLLMLLTKYDATESLLLYFRHVIDPLKKSQIILKSVQKMDGKGCEMILSAINEMEMSEHMKDFSETLEFVCNEKKEVKGSIFKCSGKVINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ23</accession>
    <name>L7JZ23_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">THOM_1015</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JZ23">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1015"/>
    <dbReference type="HOGENOM" id="CLU_000203_2_1_1"/>
    <dbReference type="InParanoid" id="L7JZ23"/>
    <dbReference type="OMA" id="ICSSLYI"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 19" id="KW-0408">Iron</keyword>
    <keyword evidence="15 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 19 24" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="22">
        <location>
            <begin position="110"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="688"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="1112"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="1297"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="528"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1045"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ELQ76017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1386" mass="157875" checksum="EE6708ADA5311C7C" modified="2013-03-06" version="1">MLVFQTNINTFTQTKENKTTTQIYIECLAENTHLKLIVSDFFPYFYVKIKTDKNDILNFFATRNIVVLSHKLSTKKNIYGYTMDNESFLKVFFWNVVVESAARRACENVYEVFDSNIPFNLQFMVDMGIVGMSYLKIDMENGQEVRMEDAGGVNGVFSTSLDVHGDGQHSKRHRSEEEADTKYVDAVCSAHRIGKVYHISHKAIKPVDRDDIPPFKVLSFDLEVNNRDNRFPESSIDEIIQIGNTVKTEEYKQTIFCQRSTASIAGVDVRSYDSEREMLEEWIRFVYYEDPDVLLGYNISGFDLDYVVGRVRKLGIPFCLCRLYTDLSKESAIRRIINTCARTLKDFESDGINAKYEQPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAHNTLHKVNAKETHKMSKSYERNEIGREDAKKKQSSPSHVVKNEMPRPVIDQVVYDAIKETFKECKNCNSTRKEMFNDYQGRIVVDMLTVIKKEHKLRSYTLNNVSVHFLGMQKEDLPYYLIRGLFNGDDKTRRRIAVYCLKDTLLPLLIYEKLLIFITGVEMVRVLGVPINWHFNRGISVKIFGLILREARKNNYVVPSVAVKDEGYMGAFVIEPERGYYDEPIAVLDFASLYPSIIIAHNLCYSTMLLGTRHGIDKNKDAERSPTGSYFVKRDVRVGILPVILEKMLKKRKEVKEKMKNEKNPFMKTLLNARQNAFKVSANSVYGFTGSAIGRLPCIDISQSVTGYGREMIIKTKNVVESVFCRSNGYDFDSHVIYGDTDSVMVRIKKDDLNVDFVFEVAKEMANKVSECFVKPVKLEFEKVYFPYLLMNKKRYAGVIETREEIKEEVKVKEVVNDGKGGDSVGAVTKKESKIEVLVNDGKEGDLVKAEAKEENKIEEVKVEEALPNGKGDDTVRAVARENVNDNSINKGKGISGTTEQPKVKETSNGNIPAHGLMTGISSAAGKAKTIGINATGSEEERTKVKEPVKKYKIKRRMDTKGIETVRRDNCKLVKSLIEECLDLLLMKRDPERAKSFVKAVVRDLYLDRIDLSLLVISKTLSKTNYAAKQAHVELAERMKKRDNAAVSIGDRIAYVIVDKGPNVIAYEKSEDPLYVLEKNLPVDVNYYIEQQIMKPVHRLFDPLMDNVNELFVGEHTATRKKGTLSGPMAQFVRKGVTCLLCKERGSVLCKRCLPNYFSVYVGKVQEMKEKEDVYNKCWRECQRCIRSVCTEVLCANKDCPIFFMRSKVIREIGEIDSQIKQLNALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ27</accession>
    <name>L7JZ27_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60s ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ27"/>
    <dbReference type="FunCoup" id="L7JZ27">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0751"/>
    <dbReference type="HOGENOM" id="CLU_084051_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ27"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="217" mass="24728" checksum="724CD31969BDA0F6" modified="2013-03-06" version="1">MGRRPGRCYRYQKNRGYIKSKYCRGVPDPKIRIHDIGKKGAHADEFPCMIYLKSLVKEQISSEALETARVTANKYMFGAAGKDGYHYRVLVHPYNVLRINKMLSCAGADRLQTGMRGAFGKPYGLCARVSMNQRVLAIRTKPAFVKHAVEALRRAKYKFPGNYEVVVSNEHGFTGIQKDVYEDLKDKKLLMNRGDHVSIIKEKGSIAHFLKMKERAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ53</accession>
    <name>L7JZ53_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0702"/>
    <dbReference type="HOGENOM" id="CLU_467850_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ53"/>
    <dbReference type="OMA" id="VHKFIAF"/>
    <dbReference type="OrthoDB" id="10428619at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="613" mass="67947" checksum="59523B7319958749" modified="2013-03-06" version="1">MSAPENKPPTYVIKEHRVQIGERGAEKDIKVPYTVLEGGTVILVLGELHGSSRAVLEGMCNSVACLDDVQHFIEESGHSKKSAIKKIILDSRVSVHSTSSIFNILYFANNQHSNVDAKMQRTQMLLEQLGLSACFYMNCSELNKLYHTLVAMGVFVMQGYDVFFLDDAFCGMSECECEKLVIIAEELAKYYGVLFVVGSDGYGGGGALEEVYEGMGCDEGTAGDTTVHSKDDKTGHSKDDKTGHSKDDKTVHSKDDKTGHSKDDKTGSTSVNRKCFKALVVRDSAAELRNISGLSRVIKDVVARNENAARLSDGRSARLKKDEKILKSLLRGITGNFRPLCVAFQVFLILIIFVGVALLKNSSDQFKIELLVRNTAGGERADIKDALTPAFLEKEHGTNGLVLCASLISFAVPLVPFFALRRNVEVLFADCVHSKRIISLNVLARMLHECALCACFSLIMCVMSALLLSLSPVFSFLFVLVSLVSARLFCLVCADLRFSVAGRFLLYACSFAPAVLYPFLLAYPLSHDVHKFIAFLPQVSVLRYMHAVLYTAIRPALAHEHRKVFDTFLNALYFPTIGDYRVGLIVLFLYLAVLWMIAFFVMKNKLRRAFRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ67</accession>
    <name>L7JZ67_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0653"/>
    <dbReference type="HOGENOM" id="CLU_3377384_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ67"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="34" mass="4135" checksum="3DB15E414656B509" modified="2013-03-06" version="1">MYLIACEHLYMSIVNYVHCTERSVESDYNMCFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ74</accession>
    <name>L7JZ74_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ74"/>
    <dbReference type="STRING" id="72359.L7JZ74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0341"/>
    <dbReference type="HOGENOM" id="CLU_1496650_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ74"/>
    <dbReference type="OMA" id="KWIVKDW"/>
    <dbReference type="OrthoDB" id="2158148at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="180" mass="21427" checksum="B56D42387A547F34" modified="2013-03-06" version="1">MPLNLEKIEKTITSMDRTYDANFGEWIRNEENCKIIAYHLKKYIVDYPAHDFVVVLKWIVKDWTLRSIIILTKMMIITDLEESFERKMDILQGLIFTWNPVFIAEFVVSVSRMLNSTMKKTFVLRLFEEFEKERIKLVVEQMGNKIEEGIKALLVRSMSSGQRKKRSVKRKRLLEAYNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ80</accession>
    <name>L7JZ80_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993830">
        <property type="protein sequence ID" value="ELQ76719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0287"/>
    <dbReference type="HOGENOM" id="CLU_1714603_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ80"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="153" mass="17692" checksum="90AAB72DE5D63D7A" modified="2013-03-06" version="1">MLYLTDINASETALYTHFPFNFTKSLPECAKIDVYIDEYPVIKYLDSSPRYLTRISCDRIECDNDINIPDHIEKLDIKKCVLGTNKTLTLGKNCKSVKIMDMRGRLIIPGLMEGEMGLNTVCGILNFEYNTDETEKQRKLELCRSKNLYNSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ94</accession>
    <name>L7JZ94_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0679"/>
    <dbReference type="HOGENOM" id="CLU_3260842_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ94"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4817" checksum="464CE53555356252" modified="2013-03-06" version="1">MSILREGGKGNRMASLMEVCEMDRVQNKILRLDEKLPGTKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZC6</accession>
    <name>L7JZC6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0908"/>
    <dbReference type="HOGENOM" id="CLU_3368781_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZC6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="35" mass="4309" checksum="A0FF4BCE6B9DB74A" modified="2013-03-06" version="1">MQIDHKHVKEKCERMIMKIENEKEKITGLYYVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZG1</accession>
    <name>L7JZG1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0172"/>
    <dbReference type="HOGENOM" id="CLU_1679282_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZG1"/>
    <dbReference type="OMA" id="LYTINQW"/>
    <dbReference type="OrthoDB" id="2193082at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="19359" checksum="2B15A6B666A4CEFE" modified="2013-03-06" version="1">MAELYTINQWKNELRHYGIRIGNGWYFSLEEILYLKKKDVIAYHPLFASRIYKNACNSKNFQKKFAIYCHFKENEYNIIDNRLYHHTKNFNRKYESCIAVLQFVRKDENFELTDCVFTIISETDFYTLKVEQCVLDLKLSKKHIKDSCKLVPCESMVMLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZM3</accession>
    <name>L7JZM3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0085"/>
    <dbReference type="HOGENOM" id="CLU_628795_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZM3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979172" evidence="1">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="436" mass="49884" checksum="37E43CFBEB39D7F4" modified="2013-03-06" version="1">MGFLQNLLIAILFIVYVQCGEVNNEGQAARHIMLTADNANEIFHKNFRITLRDKSEHLVSLSRIEDLTMLICKMMMEFMDLRNHVPGSGQPSAKFDALERELSMAFIGPRVMDLESFANMFALTMPFPDPDIFSRFDGDIDPLQFTTMVSSSEYKVNLQALMWYIDDIYAVCRVMNTMCKYALGVFSLCVRPRYGDLGSVLSDPSTTPFREMDALRARASVPGRVYQQPADFISWIERLSALRKSLVHYLEFGGRLEALTRVCRQARFAEAVIKKNVSDYNEYLDTLEKDSAKGSHAQGALNSKRKPLFIHSVPLDDVYRDCPAEFERKIESLKEEGEPTVLLLMQNLKERGGVLPQELRARRAQFWTWLETRRHKTVAIDVGGLCDKICAHEMYLVTVFLQAAFGRMRDSIDERLGKYWLKSSLYDVEPSSCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZR3</accession>
    <name>L7JZR3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Divalent cation tolerance-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993841">
        <property type="protein sequence ID" value="ELQ76536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0479"/>
    <dbReference type="HOGENOM" id="CLU_098807_2_0_1"/>
    <dbReference type="InParanoid" id="L7JZR3"/>
    <dbReference type="OMA" id="MEMHLAS"/>
    <dbReference type="OrthoDB" id="2017693at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="DIVALENT CATION TOLERANCE CUTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419:SF8">
        <property type="entry name" value="FI09726P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="145" mass="17321" checksum="CBBD9907A2CC47D5" modified="2013-03-06" version="1" fragment="single">VNYVNFIFCKIQSYLIRLSIASKCNLKNFESLPYALNEYSMEFPVIIFTAFKDENETNLILESLLRKKLIACAQKIQRVESTYVWNGKIENEEEIQVKMTTFNRCVPSIENIITKMHSYSFYQFIAVRLEYVNEKYIEWMRQVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZU4</accession>
    <name>L7JZU4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable valine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_0010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZU4"/>
    <dbReference type="FunCoup" id="L7JZU4">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0010"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZU4"/>
    <dbReference type="OMA" id="RQWYIRN"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="72"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="816"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ76983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1015" mass="116810" checksum="6A760E35B4A99A21" modified="2013-03-06" version="1">MGDRKQQKELKKQKKLEKFIKKQSKAQQTECKKNIKLQISQQDAITRTPEGELKNVNQAMGAYDPMQVEEGWYSWWDKKGFFKPEILKKHRDDVREPYVMALPPPNVTGKLHIGHAMMVAIEDAIARYKRMQGFEVLFVPGCDHAGIATQTVVEKKLYKEKRLTRYDLGREKFIDMVWKWKEKYGDTIIEQIKRLGTSVDMGRYVFTLDKKVNEGVIEAFVQLYERKLIYRESKLINWCSKLSTALSDLEVDHKPVKPFTKLQVDGKKYVFGVLYAIKYPLADKGSAEINDYVEIATTRPETIIGDTALCVNPMDKRAQYLRTKVAINPITKEVIPIIFDEYAEMEFGTGVVKITPAHDFNDYDLAKKHGLAVKNVLNENNEVCVEGSFYKMKRFYARIKVLEYLRSTGLFVSETGYEQTLPICSRSGDVLEPHLKKQWWLDCKGMARKAIEAVESKELKIVPDIAIKNWNYWLSNIRDWCLSRQLWWGHQIPAYEVLKDGESAGWVVARTKDEAKHKAETTFKLQTGDYVLRQDEDVLDTWFSSGLWPFVILGWPAATDDFARYFPNSILETGSDILFFWVARMVMLSLELTGKVPFNTILLHGIVRDANGRKMSKSLGNVIDPLYVIEGVQLDELAKSITATNLDPKEIKAALEGQRKDFPMGIPRCGSDALRFTLCSYTSGMKDVNLNILRADGYRKFCNKLWNAFKFVLKAVESTKLSTDDIDEFEKSFLKSQKRADADRGPDRSAADSLEDRELFVEISSGVNERSVSKTDVSDKLFVKTFNKVEPELEHSVKTLSISENGLSSVRCVIEWLYGKREAMIEEFISSMDTFNFMSATQCIHQFALYTYCDVFIEVVKQCTQTEYVAALVLVFRDIILLLHPFMPFITEELFQRLRALRILNLLESITVERLPRRFDHEFTDSFSQITSICRSVRSIMDSNNLKSADVQFNDKNTLCFEKEMRALCRNVRSFEYVEEVQGRYIDQVGPVKFSILPEDKSVISDTASSSETEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZX3</accession>
    <name>L7JZX3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0152"/>
    <dbReference type="HOGENOM" id="CLU_1070382_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZX3"/>
    <dbReference type="OMA" id="TDKMINM"/>
    <dbReference type="OrthoDB" id="10344421at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="260" mass="30909" checksum="91DE322F9E854031" modified="2013-03-06" version="1">MEKDGKKERKVIHRDYLSNSNPYAFLNHYDPENALDAGSLAHLEATRRIQPEMTPLADIDCLVRENEVQTDKMINMMKNEVIEKLKNVLTKNDLEFDKIYRERTGMMSSESIGGQDIYEFSYNDEVIFNILEEYQHIVEMNSLYDEYLRISLYKKQRRLHEKVFKGFNDVLASKRYVPKEIDLPIPKEISNLSEALVFKTIVDRYKEELQQAHRERRTFINSHILECYGIFLEDKKKKEEVRNLHYECVKKLKDSLAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K022</accession>
    <name>L7K022_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K022"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0617"/>
    <dbReference type="HOGENOM" id="CLU_2190374_0_0_1"/>
    <dbReference type="InParanoid" id="L7K022"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="12163" checksum="2E6E45116FBD2969" modified="2013-03-06" version="1" fragment="single">VLYTNDTCTIGMFHCNAQMYFSVNVGLCTSTYDVDVVSVVAKVYCLGMIVDISACSVGVMPDNVSVVCDGMLLWIDRGSVIGRVARCKYPMVYDLLVWRERADWYVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7K031</accession>
    <name>L7K031_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K031"/>
    <dbReference type="FunCoup" id="L7K031">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K031"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0375"/>
    <dbReference type="HOGENOM" id="CLU_071479_4_1_1"/>
    <dbReference type="InParanoid" id="L7K031"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="138" mass="15884" checksum="BC9EC8DB8DE93A17" modified="2013-03-06" version="1">MAQPVAQLENVLTEINTSKCKKTFNRFKSDRFKRVKPSWRHPRGIDNRVRRKFRGTISMPNKGFKTASVIKNLTPDGYRKVMVSNVRELEALKSLNTYYCAEIRHGVGAKKRIEIVSKADEYNIVVTNRTGKLVEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0C6</accession>
    <name>L7K0C6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transport protein particle (TRAPP) complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0C6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0317"/>
    <dbReference type="HOGENOM" id="CLU_1723707_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0C6"/>
    <dbReference type="OMA" id="FPNPYGK"/>
    <dbReference type="OrthoDB" id="10327684at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="18044" checksum="F8930151B773DC60" modified="2013-03-06" version="1">MINNKFYIAFLEETIQKHDYDCESIGLALARLFPNPYGKDGVFNLDKYFLVTIWKMITYKEVFEVEMENGICVIGSCVPPLYDSFRHCREKYLARLDKLLSMYANIIRGYLRGCKIKACVEIDHDSFLYLKVKQAKDGRSRVLLTETATSRVCEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0E0</accession>
    <name>L7K0E0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0E0"/>
    <dbReference type="STRING" id="72359.L7K0E0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0075"/>
    <dbReference type="HOGENOM" id="CLU_567638_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0E0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="481" mass="56834" checksum="FE7958F3FFC49245" modified="2013-03-06" version="1">MSSSSSFINHLFTILETPTNHPYIRWSSTGKSIIIPNQHMFTLYVLTKYFNHDNFSSFVRQLNKYGFRKVKNTLNNVHEFRQEHFMKEKPFLSRWIRRRRGNEVKRRIEELWIKYNCLWREMSEIKEMMGMNTMRFRTGKNLDGVSGGEKKDDVVRNKKRIVMKKKELGNEKTNSCEAECGVVRKENADSNTMINEKMMRRVEGESTQEKYIIDCQWMNNKEIGNNTEKDDQSDEEKLYNDCRANMNETNACQRNTCEYVYRNFKKLGEAVYDGPSAKNDELSFTGADISFCYGKKTGMLNTSGNNYDKLESFFDSNRKYESVKTYDWAFEESFKEDQLRNRRENEDLTMKADNHIGITRNIFSVNQHKSLNGNTPAKKNVAVIENTEYDQMYITRFLSTLPIEITNDHLNADILIISDKSVDNYVLVKRYLENDKIVFLTLDSFDERRCYEYLRMGIKEVVIKPYCSDTLFALLEKYIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0F4</accession>
    <name>L7K0F4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2Fe-2S ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0F4"/>
    <dbReference type="STRING" id="72359.L7K0F4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0371"/>
    <dbReference type="HOGENOM" id="CLU_082632_5_0_1"/>
    <dbReference type="InParanoid" id="L7K0F4"/>
    <dbReference type="OMA" id="TPMEEDM"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF72">
        <property type="entry name" value="2FE-2S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="124" mass="14034" checksum="5679074DC90DC57C" modified="2013-03-06" version="1">MLKNVKDEKLINFIFLDKTPKEVFSVPGKTLLEVAHANKIDLEGACEGSLACSTCHVILDKKLYNSLEEPSDREYDLLEQAFMPCNTSRLGCQVRVDERLRNSTIKLPRATRNMAVDGFKPQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0G1</accession>
    <name>L7K0G1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0G1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0391"/>
    <dbReference type="HOGENOM" id="CLU_1810900_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0G1"/>
    <dbReference type="OMA" id="SINMRLI"/>
    <dbReference type="OrthoDB" id="10367267at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="17804" checksum="D37C623B2943C425" modified="2013-03-06" version="1" fragment="single">VFVAINSEEVLKKQQEIKQEKSIILQLYKNCCKSFKNDILHYKIRNKENIEFYKKCKEYFLIKFMILHSYDELVKSINMRLIVFDEKLFLYLLEKVIDSSDIVRARKMLTFARKRCYFDKKYYELKERYKRMCKRARRFDLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0I6</accession>
    <name>L7K0I6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0I6"/>
    <dbReference type="FunCoup" id="L7K0I6">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0I6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0236"/>
    <dbReference type="HOGENOM" id="CLU_018395_1_0_1"/>
    <dbReference type="InParanoid" id="L7K0I6"/>
    <dbReference type="OMA" id="ARQWTIR"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF18">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="14"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="267"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="358" mass="41042" checksum="98428183C81E56C0" modified="2013-03-06" version="1">MTVMFSRPGKSHNLSMGIVGLPNVGKSTLFNALTKRSVPAANYPFCTITPEEGRIEIPDERFEYLVNLYKPKSVVPAYLSVIDIAGLIKGASQGLGLGNEFLENIRRTDGIFQVVRCFEDENIVHVDEDIDPLRDVRTIKDELRLKDLQIITKRIEKQKRETVVDVKKKKFETQTLDKLKEVLEVKWTNEAEWTPDEIEYLNTLNLLTTKEVVYLANISEDEYNNKLVNKHLRALIKTERNVLPFSATSLSDVFVRKLLWKGYEALKLINFFTVGAPEVKSWTVREGTKAPQAAAVIHSDFEKNFIMAEVMEYKDIKLYGNEQNVKKAGRYLHKGRDYVVEDGNIILFKINKIAKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0J5</accession>
    <name>L7K0J5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA export protein (Contains WD40 repeats)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0J5"/>
    <dbReference type="FunCoup" id="L7K0J5">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0J5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0165"/>
    <dbReference type="HOGENOM" id="CLU_038526_1_0_1"/>
    <dbReference type="InParanoid" id="L7K0J5"/>
    <dbReference type="OMA" id="EAMDQSI"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="312" mass="34508" checksum="4860477E8E922C9B" modified="2013-03-06" version="1">MLYNLSSVSKAAVVPNDTVSDIALHDTYDIFAATSWDCSIYYYDANDSLGHKSTTKLDAPLLSGSFFDGNKMVAGAVNGTLYVVDVATNQVSEIKGHDLGIKKVKVYNNIVITGSWDKKLKFWDLRSNAPLFTHELANKVYAMDIKNGNLALALSNNTVVMHSIGDFQRQRILRTKLKWQLRSVCCSNDQVLVGGVEGAIEVLNMSDVSDHFYKGHRNANVLYAINCIDVHPLNSSLIASGGNDNNVLIYNKQQRIKVHTERTNAPVTAGRFNRNGQFYIYSTGEDWSKGYPATQFPTSVCVLDVKKAKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQU2</accession>
    <name>L7JQU2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridylate synthase</fullName>
            <ecNumber evidence="2">5.4.99.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="5.4.99.12" evidence="2"/>
    <dbReference type="EMBL" id="JH994107">
        <property type="protein sequence ID" value="ELQ73794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQU2"/>
    <dbReference type="STRING" id="72359.L7JQU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3296"/>
    <dbReference type="HOGENOM" id="CLU_014673_4_0_1"/>
    <dbReference type="InParanoid" id="L7JQU2"/>
    <dbReference type="OMA" id="YYMEIAS"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="334" mass="39600" checksum="8238CD03B18B2E93" modified="2013-03-06" version="1">MKLVLTIAYDGRKYHGLIDQPSQNTVFSQIRAALQRMRIPHSLTIECSGRTDKGVSAANMVISLPVEKPGNYDVMFNNVLPDDIRVKRYALVGDDFSARFDCTRRVYRYFFHCEDLNEYERVGNALVNGLRSGEFRIQDFCTKSVERNFNKKMKRQNLDQKDDNNIANITIPAVPGNNTKRIKHEAKNNKNCNEHPKQLLNDRIKIITDEQHVKSNHDATLTNIPKTNQSITLFDQNFYNRDIDYMRFKKLNEIYYMEIASKSFLHNQIRRMFYFIRKNVGKKEIVFYEGLAEPENLIFYQAQYDKEIKWKKSRKDDPFLYEIEKEKHKMIFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR02</accession>
    <name>L7JR02_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3181"/>
    <dbReference type="HOGENOM" id="CLU_953762_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR02"/>
    <dbReference type="OMA" id="NFERNAQ"/>
    <dbReference type="OrthoDB" id="2192073at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="318" mass="36257" checksum="2F4AF8626A7873CA" modified="2013-03-06" version="1">MRYSLLHDHSNRSKTFSFKIAFKIREYAYKMNISIYFYLIAIYSSALPISRLKQPFKMIQNRTFGTTVVKINVHLDSTALVALKIALASEFSMDLNGMNTVRNFFGGIFDIINEDIQNIGIQIRGDFSDVVLKDMPYDLTRCIEGNPVLARTNIVKTKLTAELGPKMGNTLVLLFCPERVIMPPTSALLNEGGCSNTGGAMFGELRTLKDVITDLVYKMISYGNSRPLDNTSNFERNAQRYVSECIGHEKNTFGAFERDLKAVRHLGTERYILKDGSKLKEHDLMDDVYLLRSRKRIVGHPTEDYSNDHELYTDFNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRD5</accession>
    <name>L7JRD5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRD5"/>
    <dbReference type="FunCoup" id="L7JRD5">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3215"/>
    <dbReference type="HOGENOM" id="CLU_021695_0_2_1"/>
    <dbReference type="InParanoid" id="L7JRD5"/>
    <dbReference type="OMA" id="HRECVAP"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ73840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="583" mass="65789" checksum="CC9AE0F37A2CF3D4" modified="2013-03-06" version="1">MDHYDIVILGTGLSECVLSAVLSHSGYSVLHVDSSDRYGTSFQNYNYADLCTRYGKPCLPILAPLTNKFSIDYTPKLLLAGGLTQRVLIKYDLSSLVNFLLIPGCYVYKHRLYEVPTSETKSLQTGLISFLQKPRLVRFFYNVRKYFRRVPIRLMATMREQYRHYGIDEHSAQVIGHAVALNLDDEYLDERPECTFEKIRLYIESLRENGDEISPFVYPLYGMSEVCQAFVRKASVAGAVYRLRTSVVEIKSNGEFSAYGDGEGGDGGSKGEGDDGSCKGACIGEECGKKGRGEGEGECRRDECGDESSKKGCGDESSKKGRGDGGSKDKKDRKDENNNTENDERNNNEIIENENKTDEKYKIEDKQEGECKEKERIDGSAKQNVKNAEDKDDEPLHSKNAEKNKKGPHYNFTVKIRPADEEPLEIRCKALISEISYTPNKQPTNKKVIRATLIIDGVVPLLKHVPSAQILFLSSGLHRKTDVFALVLGHRECVAPKGYKVVLISYVKEGENDRTLDRIVHLFGKVVDRFVREEEMMVNERVDRGWYVVGGCDESMHVENGMQEVVKVLEKMKRDGFKIECSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRI0</accession>
    <name>L7JRI0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_3030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRI0"/>
    <dbReference type="FunCoup" id="L7JRI0">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3030"/>
    <dbReference type="HOGENOM" id="CLU_013528_3_3_1"/>
    <dbReference type="InParanoid" id="L7JRI0"/>
    <dbReference type="OMA" id="HAWPASE"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="25"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="377"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ74078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="626" mass="72650" checksum="034A684D7570EF2A" modified="2013-03-06" version="1">MTESANTAKQSLHIKNTLTNNLEPFTPITPSQIKMYICGPTVYDSAHLGHARTYICFDVIRRILEEHFHYDVTFVMNITNIDDKIVKKAEAIFSEFLKSNVKYVNVDRLGQEQRRDAFVECVEFVTRKYEEEFFEDMRRLNVRAPSFVTKVTDYMGEIVRFVERLVERGRAYVVNGSVYFDMVKFMEEGGQRHFRGDDAVINEAEEGSEKKHRTDFALWKRCKEGDLYYFESPWSNGRPGWHIECSAMGMDVLGHTMDIHAGGIDLQFPHHENEMIQSRALTDQPYVNYFMHTGHLHIEGLKMSKSLKNFITIQDCLKKFTARQIRVMFLNNCYDSTVTYRYEAMEYAEKIEKKLFNFISMAEAEIAGRERFAGEKIQTGGVDDNARGDMNSRTQTNTNKDLRDDQESVHKHSTNKDLRDDQEPVHKHSAEIVMDNGESGECNNGPITDDDEMAYKDESTEEDPNERTGQLNNTAKDPYYVINKRMYGPLDQNDKMVLRMLEMAKKEVHESFCDNFNTYKTLTAILNLITIMHQKMYNCSGQVIQLVLDYIKRILSMLGLEAKQEIEEDMLPSIICNFRSEVRRLCKEKKGVQELFHACDVVRDEMVDAGYVIEDKGNGSVIRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRX9</accession>
    <name>L7JRX9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein involved in inorganic phosphate transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRX9"/>
    <dbReference type="FunCoup" id="L7JRX9">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2938"/>
    <dbReference type="HOGENOM" id="CLU_105537_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRX9"/>
    <dbReference type="OMA" id="ITYSEYD"/>
    <dbReference type="OrthoDB" id="2190094at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="233" mass="26987" checksum="E51079F044734FC8" modified="2013-03-06" version="1">MEIPLTSIDQALNIVASLVCMQATKYVELSHPLYLWTLRVLYVISQLMLFLCVHLIKKSIMRQNDRRVVKVPRELKWNEVPETNEEEFEEITYSEYDMREAGRLIKSALFQIPIVLFLHLKFGLPQPLALQAISIVKSFFLNPLFIAHLRHKSVLRPFDKNMLFGKAKEDGEERRKREDEDVVENRDAAKVEDGKVKDVTEGVVSLDKEPCAAKDQSVDKEADENSSTKRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRY3</accession>
    <name>L7JRY3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994067">
        <property type="protein sequence ID" value="ELQ74164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2921"/>
    <dbReference type="HOGENOM" id="CLU_667629_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRY3"/>
    <dbReference type="OrthoDB" id="10596023at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="412" mass="47871" checksum="FE1164533FD131EA" modified="2013-03-06" version="1">MAAAIENATNSCFNVTREYKAPENDFLGSEGEWYQEMSGFANKTKFTNTEAWFDNEDKSTQPSTSSYIDPSLVLCHTEETSSKSGTFVDKNYNKKTKTQNKVVTSSRYSQKCETSSMKISSEKPTGKFDSGNRKNIHRIHDSIYYINSDYDVPRIIGSKITIYSSKHCSFKYIYNGVLNTVWHVFYGHYTGDVTSKLRFHIQHDDKLRFLKNTISDPQDEKALSKEVLKSIRIICQSHNKLYETKSFADSFNTKGAKASQTANIIQWRGSCLTITHQDMQRLKEENQQYISTFLNIYQTLVHAKRNEITFYFTKLQNPIQPSNYHVSYSYSEMMNYLIENVDVFFRIIEIRPMAFKSLLRLDILTILTNQLSIFFDSNLSAKLLLFPELLSLRQYNYVINEKTNILTHINYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRZ4</accession>
    <name>L7JRZ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Homeodomain-related, SANT domain, DNA binding, Myb transcription factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994066">
        <property type="protein sequence ID" value="ELQ74174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2912"/>
    <dbReference type="HOGENOM" id="CLU_014217_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRZ4"/>
    <dbReference type="OMA" id="CNEMNGL"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="512"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="512"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="564"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="568"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="927" mass="105946" checksum="100428250C3A7CA9" modified="2013-03-06" version="1">MSINQSYQNDTIKKGNVIINGGPAQQNAKHNNHVRMCNYLAGSTANTKYQIYLKNKKMVLKPRMNNNRNAAVDAKHNRKRCGDDDGGSSRGHKNVYGEYVNIKDGTRGDNAEREGVDGHAINRRIKPRMHRARSRSVVDECVLDGGNEDDARCADDSVLRAVPDDRDAQKMGRGIDSNGRDSRGTADQDDGHRLPGRDRRKNEQPCRERAERVAHSDEYSEDWDECYGDRKESRGYQRRSVHSDGHDYNDDVLSRTSEVRPDRISEVLSGRTSEVRPDRTSEVGQSRTSEVGQGNIERPSKYKGHVSEYKTNDHKLSRSKEHVSEDNTHHYDDKMPGSNRNDDYAQRHRKNAFIKHSSPQLNGNQQLKYHSTPESNTRTDELPSQRTHAHKERMIDFNSRDFRINDATSVSINNAASVPINNAADRRTLSMLELEDPRKAHFDFRLDHYRGLNHSNTYAAINSTKGRTNASESSITRVTAMTTNPDIPLPNSFQTGHLYYKDFYKSKLSGKKSEIIKGPWSKEEDRRLISLVNIHKPKNWSLIAKLMKTRIGKQCRERWHNHLHPAINKAPFSTDEDRLICSLHARFGNRWSEIAKYLPGRTDNAIKNYWNSKVQKRMLKRRAMSVCNEMNGLDRLVAATVGGKGRSRSYGDEVGDDGRNGGLENERLEGTADCDVRHGEGIHEDAAYAHEVGDKEIRTRRADTVYANELNKSEELRTRRADTVYAHEEIRTRRADAVYAHEVNKSEEIRTRRADXXXXXXEIRTRDRNVSLPDSRDLKNKRAENVYARHSKGAPQGQPDHNKSSPQRRTEEEISTAMASTRMRTTDEQPRTLSNTMTSTPFSFSDRTHHSDGVVLPHERAHNTSVVRNEHVERYARTVRQASAAEHLTRRTHSVDTDREGDEKDDEKACEILLSFKKNDELNVNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS05</accession>
    <name>L7JS05_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3033"/>
    <dbReference type="HOGENOM" id="CLU_2832982_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS05"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7920" checksum="BCA2D5FBF57D7DE4" modified="2013-03-06" version="1">MLVLLPARKDWMVGWRWDDMSGCVWMWVNVNVWALIDRVGGAVWRYGDGDDRIFMWTSMFWDGIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS31</accession>
    <name>L7JS31_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2817"/>
    <dbReference type="HOGENOM" id="CLU_170542_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS31"/>
    <dbReference type="OrthoDB" id="2197496at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9405" checksum="73BA48996AD0E75D" modified="2013-03-06" version="1" fragment="single">VPIMVFDFCGGILKYTMLIELNVTYYFVLDYESVKDEVNNTIDGDDIVFLLVDWRLNDNMRDFIERKMKKNVFILINSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS64</accession>
    <name>L7JS64_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2831"/>
    <dbReference type="HOGENOM" id="CLU_1349741_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS64"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="203" mass="23748" checksum="68FA3E09FF5F53E5" modified="2013-03-06" version="1">MKKAIEVASQDNRVVSQPIIYTRSYEQENISNIQKKQIKEDSKAIYTTQESLKKETSQILTRLGVWRLAVYITKKIIKLLKQSNNQVSEIKSIIQKNGRSKSDMCFGEGTFTKPKTQIKANIERHGMYMKDFRYRKNNLSLQTPVNIERIDLKNNYILIATLNICSVLKKRVDLLELLLYKKPTVILLQETPWIKNFPQERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS69</accession>
    <name>L7JS69_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3208"/>
    <dbReference type="HOGENOM" id="CLU_2322004_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS69"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="99" mass="11754" checksum="552BF8B94A65302D" modified="2013-03-06" version="1">MKFYLRSTVRDFDKFCSQNPTFCPIYRQTFTTNDETRIVLSKTEGSEIYALCDTEDFDIKDLFEYKFLQDDDNNIVDEGRQTKVKKAKQSSLFNFMKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSA6</accession>
    <name>L7JSA6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2934"/>
    <dbReference type="HOGENOM" id="CLU_3193996_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSA6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5188" checksum="869A2034782F98ED" modified="2013-03-06" version="1" fragment="single">VQHHSFNLKNNSGSNETIEALVEDINDEHITRQAGKKNSSYHPLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSB0</accession>
    <name>L7JSB0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_3137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSB0"/>
    <dbReference type="FunCoup" id="L7JSB0">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3137"/>
    <dbReference type="HOGENOM" id="CLU_105624_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSB0"/>
    <dbReference type="OMA" id="IMEIGSF"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ73941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="127" mass="14620" checksum="87725697828030DC" modified="2013-03-06" version="1">MEAVEESKVVEETTTAETPTVESVVRLDCSLCTAESLFDTKDLTNYLLANIKVKGKKGQLGKNIKVDCDADNVRVEYKRFMTKRYVKYLGKKFLRTKKLNSWVRLVSVSKVGYRFSYYNVDKGNEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSC1</accession>
    <name>L7JSC1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_3147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSC1"/>
    <dbReference type="STRING" id="72359.L7JSC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3147"/>
    <dbReference type="HOGENOM" id="CLU_1653480_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSC1"/>
    <dbReference type="OrthoDB" id="2188412at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ73951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="132" mass="15960" checksum="453884C8AB990CA0" modified="2013-03-06" version="1">MHAQSFPFACLICQRNYPSEKSLNYHKIIHTRPNYYCEKCEKSFFYSDKLKKHLITCGIQWTCSCGRVFVRKKWYDRHMEEHDVSKYLSEKKIIEVKPTALKYIFKCRHCKKGMKKRKTLEVHEQTVHKPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSE0</accession>
    <name>L7JSE0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative P-loop ATPase fused to an acetyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.128</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_3111</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.128" evidence="13"/>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSE0"/>
    <dbReference type="FunCoup" id="L7JSE0">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3111"/>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSE0"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="9">
        <location>
            <begin position="221"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="444"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="567"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="12">
        <location>
            <begin position="636"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ73971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="782" mass="90600" checksum="BBC104912ACBEF45" modified="2013-03-06" version="1">MDEIETDKRVADAIKQAVNQGHRSFFILNGDNSKNNVPILYNLLSERCSFLPSVLWCYCKKSKSREEKKKKMKKEKKSAKCCINDDDIKKVSYQEVDIVMGNTYEMLVLENFEKISPNTLAKTVETVKGGGVIVVLMDNDKNGLFNTRLYKSLCESDHVMFLDQNMKLISKFSLSSWRTGDENTDRLTLKNELCVTVDQDNAVAQLGHILMDRNNKNIALLKASRGRGKSAALGLAVADAVELRYSIVYIVAPHIENVKMLFEFVLRGLRGKGYKENADFDITRIFKGRSYVQKIVVKKNHRQIIEYHGFLDKMDRYPDLLVVDEAAAIPLPILKDLIRANIVLMASTMDGYEGTGRSLSMRFIEKLKKNDKDNPYVFKEIELNESIRYKRNDPVERWLNDVLILKPADYKNKLCPSPDTCQFFFVNKKTLFSYHKVSELFLKQMMSIFVSSHYKNTPDDLKIIADEPDHHVFVLLAPEKEKKLPRIICAAHVALEGKVTGERKDGNLIPWTLSEQFLDKNFLERRGCRIVRIAVHPDYQNMKYGTRMIELLVDTFSRGEARTFEFKVTEALLLPSTELSMPRIDWMGVSMGLNTRIFKFWGRNAFYPVYIKQTLNFNTGDYTSILLRNVNQCFDRFYFIFRERFLNLINFMWCEFPVELCMMLTKIKQRNEMDTEKENLSNKSIDTKYKANFGEFELARLESYVNGYSELNVVYDLIPIIARDYFHNARNFLSVAQESILLAVGGQMKTMNVISRELDITKEQVQILVKKVVAKFLRETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSH0</accession>
    <name>L7JSH0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2667"/>
    <dbReference type="HOGENOM" id="CLU_816773_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSH0"/>
    <dbReference type="OMA" id="EIMIINM"/>
    <dbReference type="OrthoDB" id="2191347at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="356" mass="40997" checksum="55A346635A62D6F0" modified="2013-03-06" version="1">MENEESLSISTDEEDYVPSNKTVARTALSNNISKQNAKSGKNRNKPANMTTNNDINTYTELKDKIRECFGDGIVVPVMSLNMLYCERHTTMFDYKKGPCRKGKYHGHKTLTNFLTCCDDSFALLNYKTLFVMRRDKAATELTRKRLEMHYKNVKKNDELGLLHLEIMIINMFAMKTSVPIDDLEKVFYDVYKVEISEFCKKHSVLRTLQILNSPNMVVSISQKHNNVVCIPTFRKEFSDYKKRADEYAQVLNVEDNILRPQVVSCSPPSHQNKKKDGEYKSRGCELFKNEKLNNLLTLADINVPRSIQKRTTSIPRPSELYKELECDIGVDPAWSYILQALNMDGEEDAFIDINKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSI6</accession>
    <name>L7JSI6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSI6"/>
    <dbReference type="FunCoup" id="L7JSI6">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2628"/>
    <dbReference type="HOGENOM" id="CLU_014831_1_0_1"/>
    <dbReference type="InParanoid" id="L7JSI6"/>
    <dbReference type="OMA" id="GKHDNRV"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="8">
        <location>
            <begin position="72"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="239"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="377" mass="42554" checksum="A4AEB78DD6473FBC" modified="2013-03-06" version="1">MKTINLDNIFSTEPRYKRLSKKNSQNKTIYNDRYTKKFGFVDKIIVSTQIVTEPRYKRLETRKVDTSPFRILDAPGVYDDYYLNILDWSSNNYISICLAEEIYLYDVASKDVINLATFEGGVYASSLKSNGNVLAAGISNGDIAFYDVEKCKLIGKSSSHQTRVTSLDWNGNVLSSGSRTGLISNLDLRDNKEISKFKFHTQEVCGLKWSNSKRYLASGANDNCINIWQLGSNSPRYSLTGHSSAVKALDWCPWRVSILASGGGSKDKTVRFWDIETGMCENSVEMSSQVCGIHFLTRYKEMITAHGYSENDICLWKVSNFKKICSFGKHDNRVLYTALSPDQTILASLAADENLKFWRILDQTDVSTPVVENIGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSM0</accession>
    <name>L7JSM0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSM0"/>
    <dbReference type="FunCoup" id="L7JSM0">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2573"/>
    <dbReference type="HOGENOM" id="CLU_046346_3_0_1"/>
    <dbReference type="InParanoid" id="L7JSM0"/>
    <dbReference type="OMA" id="EPCHIEG"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="236" mass="27123" checksum="EB1267FD699F4E1D" modified="2013-03-06" version="1">MKLNISSPQNGTNITLEVTGNAERIFHGKSLGDIIDGSMIKQEYAGWKMLLTGGSDKQGFPMDTQINTDKRQRLLRRKGDIGFKPRRKGELRRKSVRGAIISEETSALCMKVVNDLFAEKEENKTACEPCHIEGLTDRVADKTHLPKRFNKLKAALGLKDVDVSPEEVKDAIIKALPPPEEGKKRKLPKIRMTRIKHEFFSQRYEKKQEISRARREKSEKIRQEFFKKYPDWLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSM4</accession>
    <name>L7JSM4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Integrase, catalytic core, Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994080">
        <property type="protein sequence ID" value="ELQ74051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3036"/>
    <dbReference type="HOGENOM" id="CLU_2759599_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSM4"/>
    <dbReference type="OrthoDB" id="2193507at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="70" mass="8101" checksum="57759F15EA43872A" modified="2013-03-06" version="1">MVTNPGKEFKSRLVTSFSEENGIEHHVTSTEHSEANGRVERLNCTIREYIRKKSNSKIREKNDKISLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSN3</accession>
    <name>L7JSN3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2618"/>
    <dbReference type="HOGENOM" id="CLU_2428622_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSN3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="91" mass="10501" checksum="C4DF1BD61F554A3B" modified="2013-03-06" version="1">MKCDRLKSFTLKNNSFIYYKSVYEKLTFLDLENVEINHSVVFNENMKSVRLVNVHVRMFNVLKINKPCETLYIRGCKGNIVIPQVASIGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSR9</accession>
    <name>L7JSR9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2987"/>
    <dbReference type="HOGENOM" id="CLU_1422353_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSR9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="191" mass="22605" checksum="9EF49EF16E123BBB" modified="2013-03-06" version="1">MMFIKYCDILTSAMAYEYVVLFMNHTYPMDDKINKIRSKLKPDPVLLSFLTRKKAVEPLLSPSKNLQRRAEKLYFSNRRKSINLYIKSVFARIEAFEFKECTLDTYISLYEYVKKIVKRSVGEYKDILNVIEYSVYYCVIVKQARKCLDEGIVYDDLGIDLIKLDNLVEDQAVLVKLECLAKYIFENFEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSY2</accession>
    <name>L7JSY2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular protein SEL-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSY2"/>
    <dbReference type="STRING" id="72359.L7JSY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2925"/>
    <dbReference type="HOGENOM" id="CLU_041164_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSY2"/>
    <dbReference type="OMA" id="YAYDENT"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978814" evidence="3">
        <location>
            <begin position="20"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="495" mass="56543" checksum="405F65541F70F366" modified="2013-03-06" version="1">MFFFFQCMTASLLETLVLNGKIREAYDNIQNASEPSDLIYIYFLKHLRNDEDANFYLMAAENYSPFFRHIYAHKAFFNFEISAPVSELAGIYSRTAKAIVTKYLSNRFSFHDKMKFEKIRDVPPVNYLINLIGSGDKKAEETYINSVLTGQIDPRNEIQNLKKLCETGNAKAMTVLGNLYLEGYGVEKCVSTAMHYFRQGAANGDPLSYNGLGKIFMREGHKDLSLAKKYFEEAASRGSAEGDYNLFVFVRNVYKIEDMGLSYLIRSVKRSYMPALFSYAKRLLSNGETASAVSHLVPICDFDDCIVDLQGRAQKDYREGRYVPCLYKLLFLCETGSLNSIGNLLYLLKTCKGLVPEQDTLFHTYCDKLAQMGQIHHLVDLADTYFYGKGTEQSYTKAFSFYYAAMLYKSARGSYALSYMYENGLGCTKSISDAMSMLYKAYAYDENTYLLVWYTMLKIYLVIISRAVYAVRWIIGCALGALFGYHFILKRGTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT06</accession>
    <name>L7JT06_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2477"/>
    <dbReference type="HOGENOM" id="CLU_2723995_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT06"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="72" mass="8169" checksum="D60B9192A824C499" modified="2013-03-06" version="1">MALGTNLTKSFKTYLCVAEVFFDRRNNVGMRGVNFCTDEGRVQLLHDSKRYFAALFGVMVCVSLLINRVVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT33</accession>
    <name>L7JT33_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT33"/>
    <dbReference type="STRING" id="72359.L7JT33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2503"/>
    <dbReference type="HOGENOM" id="CLU_078328_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT33"/>
    <dbReference type="OMA" id="NIGRENM"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="9">
        <location>
            <begin position="95"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="335" mass="40217" checksum="DE4041C8C4BDCB45" modified="2013-03-06" version="1">MNHDVMNSLSLEQKKIIEINYKRAMNNEISPNDFFEECKRILGPVKFSHLFPTHVPQYMLYTPFPHEIRHYQHAEKERESEPEEQQQKEIKTERLQDIIEYAGVNLKEEQENIGRENMIDQELEINEEDRRNSLDYLFDVEVFVQYVNFIARKRGMEVDDSAYHAMFLALKRKLTDMIEKMVKACEFRVDYIKSEVVTKIENDIRRQLWVLEEQERKEMDKTLCKKGGDDDDSQKKKLKKNVQEREDLIIKKRLSNSVALAALGIQRKSWMTMDEAVGKPEKKSQFQSLYSPYNEKEMEKKIINRKVILDDFIYVLERDKRYNKSVFTIKEYFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT40</accession>
    <name>L7JT40_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994097">
        <property type="protein sequence ID" value="ELQ73922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3162"/>
    <dbReference type="HOGENOM" id="CLU_2656210_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT40"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="76" mass="8964" checksum="C8172EE8E7B0CB9B" modified="2013-03-06" version="1">MVRFRIDSMSITRCTAHFLYGAPFLVRNVVGHHGKEERIVTATEDECELKMVILRMITLSCLQLIRRKLNGRYYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT84</accession>
    <name>L7JT84_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994032">
        <property type="protein sequence ID" value="ELQ74658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2409"/>
    <dbReference type="HOGENOM" id="CLU_2172832_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT84"/>
    <dbReference type="OMA" id="LARKWIC"/>
    <dbReference type="OrthoDB" id="10436428at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="12530" checksum="8A64508591888D96" modified="2013-03-06" version="1">MSLTFTSTISSKEANIEKLLESLDDTTIDESIIDKYTDCMYATGKNKLSDFLLNKRDNGKMVKALRYGEIIFLCLIIMFMLVIGWNVVNLARKWICILVKVTAGFEHCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT96</accession>
    <name>L7JT96_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2463"/>
    <dbReference type="HOGENOM" id="CLU_2211807_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT96"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="107" mass="12586" checksum="6FCFF64516F4BD40" modified="2013-03-06" version="1">MVHKSERAIVVLQPTKKKIINKRVLEERKTEKERQEKQLRKKGEEIVADKMRQERRTIHWKKGTGEKNRSLAESATKKDIINGDARKIGEKIKGILNIYIRSIKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTA4</accession>
    <name>L7JTA4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3085"/>
    <dbReference type="HOGENOM" id="CLU_3282355_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTA4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4856" checksum="513E74EAA85AEAEE" modified="2013-03-06" version="1" fragment="single">VIVKPQEEEWEEEVVEEVVGELEEEVVEEVVGEWEEEVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTE0</accession>
    <name>L7JTE0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin/adrenodoxin reductase</fullName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2754"/>
    <dbReference type="HOGENOM" id="CLU_618476_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTE0"/>
    <dbReference type="OMA" id="LCNIKVH"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="416" mass="46782" checksum="20D5C060C5606A51" modified="2013-03-06" version="1">MKICIIGAGPSTYYLTNHIHTHAPSTTIHVFEKNSSPLQSLKLFHTKPTMRINNVLCNIKVHKWMFERLSAFYDGIVVAVGGRARRLDGALNKFAVYGEDVVRKGGGLEGRTGRSARLLESVLESKRMLGRGRRSAEAMGLEKKNKITKNKNNEENENTRKDVNSREMHESLVHAKPFSRLRRVAIVGAGNVSLDVANMLYEQGVPQIFILSRNELAKCAFGSYELRRCMHDKNVRVWGGTVGNDRRGMIVGERLRKCEKDSGDEEIIETENESSRNSTKIENNKIANDTRCDDPFYTSPTLLSYNPTETSFHNQSPSLQPKQTLYLLLNTVLQSIKKNVSLFNLALKTREGTKMLNNVDLVVNCTGYTGRDLSTYVCTKPLYFLGWCKDAKGNLSVVKGRAVELGDRMIDEMGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU02</accession>
    <name>L7JU02_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Rab-GAP/TBC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2257"/>
    <dbReference type="HOGENOM" id="CLU_084270_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU02"/>
    <dbReference type="OMA" id="DSMNDIY"/>
    <dbReference type="OrthoDB" id="2193149at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="294" mass="34057" checksum="EC7EE38C1F8FBB0D" modified="2013-03-06" version="1">MPENLDSSKFTLNLRELIQTYERQSADVPALDVGKNQNDLKTINVDINRNFPFYEHMADEKKPLFRNELKKTLLRLPVSYVQSMCDIVAVLMYFYLSEMTEDNSLVSLAERENTASAINMNEDDSLYDDETYERMFRTIYNILKAKYVPLIDDQFKTYLENNDIFIKMMKKRGVEIPSSKSLIYTNSTLTWFSRSADSMNDIYKIFALIISCPTSVVFLLLVHYFDAIENKKKIKMNDNDIMPKIIKLEKEFLRLQDEQVASRPKVSNKAIIFGAATGAVIAGAVLFGIFKRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU24</accession>
    <name>L7JU24_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2170"/>
    <dbReference type="HOGENOM" id="CLU_1099153_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU24"/>
    <dbReference type="OrthoDB" id="10425898at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="253" mass="28409" checksum="EEBB1D49D3B0DB1B" modified="2013-03-06" version="1">MLTLILAALSQPINLSIFIEKEESPSTTHTYKLAVDDLLARYNHTLIVHGTSVRVQRLLSFAQYTNIKMFGALELLAGSDKIDERKEEIRRVLPGENVIILVSTRLDGDLDKYSVYGICGSVVFVNINTVGNDVLYGIFLGVVRLLGAVLGAPNMVMNEEQYGDSFVDLSSLDTGKAYDGSLYTKSSIRANLDHVFTRNLTGRDLLKELKECECKYRDCKEWSVDVQMNGVEDVDELIRKFREFVGQGIAKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUB5</accession>
    <name>L7JUB5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Glycoside hydrolase/deacetylase, beta/alpha-barrel, Polysaccharide deacetylase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994034">
        <property type="protein sequence ID" value="ELQ74631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2442"/>
    <dbReference type="HOGENOM" id="CLU_681858_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUB5"/>
    <dbReference type="OMA" id="RMAEHHE"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012474945" evidence="2">
        <location>
            <begin position="16"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="459" mass="53125" checksum="37CA36A8FA60C204" modified="2013-03-06" version="1">MILFLFERITAITVATISFDEGPSQHTDQLLQYLRYYNLPVCFHVDPYKINDKDLITRMAEHHEIGLAITEEIKSEHDIDRYIRKFKRTTGLVPRFVRLPRFGWPDFAPKYCQQKNLIVTTPSLDTEDIELPNFIDFLVPTLLTLSETNDGLSLVLRDRFRYSVESIGIILHVLFHKNIKLLSFTRFYAVDPKMEQARDEDIDEESDHDESNGTEKGVVIEEEPTDEQEMINEVDRKVEYKVERDDDKNLENGVTPDKKEENKHGVLIEDIGDEDAISHGRKEERSSGGDAVSNNPRISTFKINYDTIKDIKGLEESLKKLRNFDIKGNRVNRTNTVHKDHSYTSSLRMPYNENNTKVFALEYKVEEDNDNLDVRKKFEEEGSGFKRSTKSDKDKDEIKESKIKDTNEKKEESTKKEKDDNDTKAKEITKTQSNGCMNTLFVTGSIAWCTVLILFGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUC1</accession>
    <name>L7JUC1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2151"/>
    <dbReference type="HOGENOM" id="CLU_3299684_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUC1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="4823" checksum="751779B1C636FBE5" modified="2013-03-06" version="1">MFRCLKAKIYKSFGKKWVHIDDSYDANTLIFLLWAYYTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUC9</accession>
    <name>L7JUC9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2715"/>
    <dbReference type="HOGENOM" id="CLU_1152440_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUC9"/>
    <dbReference type="OMA" id="SYFITIM"/>
    <dbReference type="OrthoDB" id="10424315at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="241" mass="27416" checksum="BBA809C94DE6B06A" modified="2013-03-06" version="1">MFIKMLKVADEMPKKQYPEEWGKIAVPVPPFVYDIAYEEFFALILFVLFQLIMLVCIVAPYETLISLQNQLCAGLGMYYMTEHLVAIAIYDLAAPLAIVVVIFIPILSFYNPLTGILALLASSSYVLSYFITIMFSFEMLRTFFIVYAVFALLIGALLLCKQYFFALTKAVVCAFCLLIIINSVSPVDMLLYAHGIVYEVGKVSKTVIAVLFPVFVCVFFVYFMFTKEILEKIAQWRNHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUH3</accession>
    <name>L7JUH3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2098"/>
    <dbReference type="HOGENOM" id="CLU_2308024_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUH3"/>
    <dbReference type="OMA" id="YGCIRKL"/>
    <dbReference type="OrthoDB" id="10402524at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="100" mass="11538" checksum="F887A2CC379A1F92" modified="2013-03-06" version="1">MPQNFNYINKYNTAEFKLTRPVNKRKVLAEKSINRDDKENNVLDDTIQGSAVDVSECMLGEIAASPERKVVFINRNDLVEIQGVDSRRYGCIRKLNFSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUN2</accession>
    <name>L7JUN2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase PCTAIRE</fullName>
            <ecNumber evidence="12">2.7.11.22</ecNumber>
            <ecNumber evidence="12">2.7.11.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="12"/>
    <dbReference type="EC" id="2.7.11.23" evidence="12"/>
    <dbReference type="EMBL" id="JH993986">
        <property type="protein sequence ID" value="ELQ75134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUN2"/>
    <dbReference type="STRING" id="72359.L7JUN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1919"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="L7JUN2"/>
    <dbReference type="OMA" id="NWQIFVP"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF550">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_44, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="258" mass="29701" checksum="051979D43BBBA8DA" modified="2013-03-06" version="1">MVTYIQKRFLGSGTYSKVYEAVDHNNNRFALKKIRLFEEEGTPSTALREISILKTLHHPNIIILVEVVHTPSFLTLVFEYMDFDLNTFITHYGFSMDLFEQVIKGISYIHAMKVVHRDLKPQNILVNLERQVKIADFGLARSLAVTIPVLSSEVVTLWYRSPELLSNMQDYNYFVDMWSVGCILFEMLTGCVLFKGGSSNEQLAIIHNAVGHRRRFFEYLIDVLGPGNTFYVEIIMGCLDMNVNQRLNAYEIEIMLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUV2</accession>
    <name>L7JUV2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUV2"/>
    <dbReference type="STRING" id="72359.L7JUV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2460"/>
    <dbReference type="HOGENOM" id="CLU_2160180_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUV2"/>
    <dbReference type="OrthoDB" id="2192938at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="111" mass="12868" checksum="D2900A6B8231E921" modified="2013-03-06" version="1">MKNEALEFPKPYNIMQMRRYLELVGWFREFIQNFSVVAAPLYNALKQKGALIWNEDMTEAFAELKLRLINARNLKLAEFEKKFTLKTDASNTGLVAVLLQEDKNGKLISVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUY5</accession>
    <name>L7JUY5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">20S proteasome, regulatory subunit alpha type PSMA3/PRE10</fullName>
            <ecNumber evidence="2">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="2"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUY5"/>
    <dbReference type="FunCoup" id="L7JUY5">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2490"/>
    <dbReference type="HOGENOM" id="CLU_035750_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUY5"/>
    <dbReference type="OMA" id="RVSMYMH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="250" mass="28214" checksum="3D78412C9852F39B" modified="2013-03-06" version="1" fragment="single">VYFSLQFFTLQKMTVLDFGPIYTPTGNIAQIDYAQKNADNGSTCIALKNNNGVLIAIEKPIDSNLYIISEDKRIKKLTRNCVIAGTGLLSDMIFFNSLVQRDLIGLQRQTASLPANTVKKVISMHSSEFTRYYGCRPLGVNMLSAVNDFGTYTLYVTDTSSKTREVRGYAIGKGAARAKTELEKIDIEELSHKRMIDNAVRILYKCFDPLKDKPFEVEIGILDKNGYREVPQEEYAEFVEAYKDLNVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV16</accession>
    <name>L7JV16_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_1704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV16"/>
    <dbReference type="STRING" id="72359.L7JV16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1704"/>
    <dbReference type="HOGENOM" id="CLU_002572_0_1_1"/>
    <dbReference type="InParanoid" id="L7JV16"/>
    <dbReference type="OMA" id="PQDWKVF"/>
    <dbReference type="OrthoDB" id="2186317at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045009">
        <property type="term" value="C:chitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="775" mass="88422" checksum="94585B34320288DF" modified="2013-03-06" version="1">MPSNVFLDTNDFSCPPKVYKKRKTLWAIIYPIFTFLIPSKILSICGMKTKEVRNAWREKIALVSIIFFLCILLGFLTFGMNIVVCKGSNQYIYGKLPEFPAPVVIGNGELYYSDEYEGLIHNLKTVKSSACKRRFGESITDSGVDPDELIKIADIYFNFNDIKRLNLILIGDRVYDPSIVTHGFYDEFIAKYTGKMADDNDLDSLALQCFKDSCYFGKLGGKTYGCLVADILLYLSTVIIFSLIILKFVLAIIYSWLIRKNRVANENLPCIMLVTCYSEDREGIKKTLDSLCNQNYLEKVILVIADGLVKGSGSETTTPDIIIELMNVDKRREAAEYKSLNGTLNRGVVYSGTYNSDTNTCKMVVIVKVGREDERSKPGNRGKRDSQVIIMGFFQKLLYQDRMSDLDFEIYEAFKDVMGMEPRHFEMIMMVDADTIVHPDALLHFNSAFVNDPKIMGMCGETKIINKGASWVTMIQVFEYYISHHLTKTFESVFGGVTCLPGCFCIYRIKVKENDKYVPILANSFVLGPYSVTRTETLHEKNLLLLGEDRYLTTLLLKTFYRRKLIFLPAATCRTYVPDTFSVLLSQRRRWINSTVHNLMELVSVNALCGTFCCSMQFAVGVELAGTLVLPVSIIFTFVLIAVSILIKPAWIPLIMLACIFGLPIILILVTSFKLQYVFWLFVYILSLPVWNLVLPVYAFWHFDDFSWGETRKVDNDDGGGHYTVEQPTTHHFNLYSLEERMYARSKDRPIEVAERELIERQIRSAMEGSIDDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV17</accession>
    <name>L7JV17_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome regulatory complex, subunit RPN6/PSMD11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994009">
        <property type="protein sequence ID" value="ELQ74886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV17"/>
    <dbReference type="FunCoup" id="L7JV17">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2173"/>
    <dbReference type="HOGENOM" id="CLU_029573_1_0_1"/>
    <dbReference type="InParanoid" id="L7JV17"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="203"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="399" mass="46219" checksum="53DF30B951BD190B" modified="2013-03-06" version="1">MLYIKIIWFEPLHMPELETILQSTHVNNDDKESAIYEMARIIISEQFYDKLAELCQSLRKLWSNLTGARASKIMKRIVGLIPPQDFNLALLFEAKMIEWCQKEELKYLKLFFLTKRVGMLYEIREYEKCLENIGELSTELKKMNDKANLITLYIYESKTYYEMQNMSRAKASLTSARALAVTTFSPSYIQAQIELLAGMYLCEDRQYASAFSNFMEALDGFNQSKCYPEACLTVRYLVLSKIIANRWNEINALLKNKNVQSYLGDGIIKILVRLGESCKQRDLSGYDRIIRENYETIKDNFILSHLAYLNDLLLDSNILKLIEPYLNVSISYLAEQLSFPVSAIEAKLRKLILDGRINGILDYYTGTLVMYEKGEDSVTEKNYFEMMKAISAFIDSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV21</accession>
    <name>L7JV21_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2178</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994009">
        <property type="protein sequence ID" value="ELQ74891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV21"/>
    <dbReference type="STRING" id="72359.L7JV21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2178"/>
    <dbReference type="HOGENOM" id="CLU_2291683_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV21"/>
    <dbReference type="OMA" id="CKINTYG"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="10612" checksum="36E7E130A39686DC" modified="2013-03-06" version="1">MKQNKTHKLVCKEFKETGTCRYKDECKYLHIIDVDDDVLCMICRKEYEEKVVADCGHTFCLKCAFTEYQKSDLCYKCKINTYGRFKPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV28</accession>
    <name>L7JV28_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing subunit of the 18S rRNA processing complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV28"/>
    <dbReference type="FunCoup" id="L7JV28">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1765"/>
    <dbReference type="HOGENOM" id="CLU_022996_1_1_1"/>
    <dbReference type="InParanoid" id="L7JV28"/>
    <dbReference type="OMA" id="GPYHIDY"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BING4 C-terminal" evidence="6">
        <location>
            <begin position="302"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="402" mass="46128" checksum="47D6DD4B86B9F880" modified="2013-03-06" version="1" fragment="single">VPLDMSKQRITNKIKNKFKIAAEAQKENKMNALLQTQERGCIVLEDGEQYPTQKFIRKNVACSVKEKAFSLDLEEDCWKSSYSLDGRHIILHSRSVVAAFDCKTLNVFFERTLRNIETSIFLHNEQYCAIASDTLFIYNKNGLEVHHLSHERNVRQMVYLPHHFLLVTLSDQPFIRYLDTSMGKEVAKLYIKEPSCGALSRRDDGIVLVGGTRGVVRFFSPNAKEPLCSLLVNSSKISSIAVKKNNFVCSSLQGTNFYDFRNLNEPVYRLPKSENVSLSHVLAMSYKNRITTFLNGTEYVKETYQSINSIEFAPYEDILAVGTKNGLSHMIVPGAGDPNIDFYEDSPFLTKKQRREREIKKLMEKIPSSFIGSKFIVEEVVEEENEEKKDEPRKRTALSRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV32</accession>
    <name>L7JV32_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1724"/>
    <dbReference type="HOGENOM" id="CLU_774306_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV32"/>
    <dbReference type="OMA" id="MYLNRNI"/>
    <dbReference type="OrthoDB" id="2195441at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="358" mass="42067" checksum="13AC5AD68AAB0174" modified="2013-03-06" version="1">MVRKNNNAKKARRDRKTNKVANRPKTVRRVDGSSSGGRKMVDSTCTNAQTKSKKTRVVYPVLSNLSADRKLSNKEKIAILENTKDLFANINSVCDCVELLYDPVLRKSLLVRIVDFMVEIDVNIASEYDSLSEEDWNEIDSMYPTPISSDKNKTLREQIQTFTNIFLKLDSFFKNVEVEGVFNVFEKYVFTSKTRYMQFLMYNMNTEDVLVYFLSALKRNHMLSAHYIAYFSSFLVRRRMDESLVQKAIACFFKYFKDLKNRFLYLSSAQYFLYILCFKQTYIEIYASFIDTLFKGDVMYLNRNIVNVFCSVHNRETVDCFIESDVSRIDQFYFDPPNISRIMKVYESSFLTFDKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV96</accession>
    <name>L7JV96_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1838"/>
    <dbReference type="HOGENOM" id="CLU_1166547_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV96"/>
    <dbReference type="OMA" id="GGFYMNA"/>
    <dbReference type="OrthoDB" id="10343734at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27111" checksum="DE1586B3B4665777" modified="2013-03-06" version="1">MLLFIYCLMTLTVADDGSQPGVYRMISWKGDPSLKVSLDKGVARIQNRETPQSKEDTATAYFIPLGIVTFKIQYKNGYFCKHDKSPGLIICKNKDDPHTTWNVVEAGDAYQIKTGGLCLKKMGEDKKTGAGGFYMNAAACGNSDIFKWKIDDLKILEENSDVSDDNLEVKGNRMKVRRGVEEVSEPNTLMIGDVDDNSGYDTYERRNSRYYRETFPYYRKEVRTPHYHRNMAFGGSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV99</accession>
    <name>L7JV99_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994001">
        <property type="protein sequence ID" value="ELQ74976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2087"/>
    <dbReference type="HOGENOM" id="CLU_3385063_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV99"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="33" mass="3602" checksum="FA5ECCB50196D395" modified="2013-03-06" version="1">MSAETIHLCEIDEMVRELGVAVSTAEPPKKCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVI7</accession>
    <name>L7JVI7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2308"/>
    <dbReference type="HOGENOM" id="CLU_524960_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVI7"/>
    <dbReference type="OrthoDB" id="10618775at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="519" mass="60396" checksum="AF8BF62282C59C3F" modified="2013-03-06" version="1">MIITSSIRQEYLQKHGHQTTKRYHLKKVDGNVADKHNMHTKTLLNHVRAHNTTISSDQSTSTPIKTYSPAEIRKLHRQIQRNKRELYGYAQQNDQSLEESLHILFTNMEYFLVFRLVKNCFVKSMHDMTELVEQKDRFFDVLALRNFTYDTCVYKRFKQMCADQARIFANHEFEKKLAIFPEFGWLGGCIDALDEQVLNDRAADLVVAFYVMGKYEQFMDGIMMEYAFMKDENEGNNMLGDDGNNILEDEASTTSKDEGNNTMRNIKYNTTSNTLGNEEGNTSNNTTKNAKSNATNNSLENLNTKTLEKDQHVRYTADGRKSDVGNNKTEILGEKSFDKKNATHTSTQTRTIRVLTKNQNLTKVFVREVLIGYLINSFLCDRYLTVAYDYITRLSFDYFCRKEDFKIVLNRTSDSFYDFLFRHLIIVQRTLHERSIFNTLLTMRHSPGLPAEFKEIHGVILSNNLAGFNIPTYEQDVQMTEQPSDMNTLYEEHMNEMYMSREFVYTGSSGYNLLAYSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVQ0</accession>
    <name>L7JVQ0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 5'-phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="3"/>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVQ0"/>
    <dbReference type="STRING" id="72359.L7JVQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1677"/>
    <dbReference type="HOGENOM" id="CLU_2114841_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVQ0"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="5">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="115" mass="13249" checksum="C9F8E5B72359221A" modified="2013-03-06" version="1" fragment="single">VSFYKGLRTTLSNGKTTTIRKERVALYDVFIPNAVYDLRIALSREIPVTNVIKASTYRRERERESFIVDSTRFDFTITKSTNQVSYEIEVELVDVNSNLDAFVDVAFNLAFLNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVR7</accession>
    <name>L7JVR7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993987">
        <property type="protein sequence ID" value="ELQ75131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1932"/>
    <dbReference type="HOGENOM" id="CLU_2251925_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVR7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="104" mass="12214" checksum="C60D85612F5BBBD8" modified="2013-03-06" version="1">MVNVEPYNADNSTLLEHVTHDEYTPFISYHTTKHRIDLPYDNRNNYEYIDEHLTRRIRAKSFDHDEQSTEYRVHAQSISVDAYESVSDDEEVAIANVLLSLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVY3</accession>
    <name>L7JVY3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVY3"/>
    <dbReference type="STRING" id="72359.L7JVY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1452"/>
    <dbReference type="HOGENOM" id="CLU_585530_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVY3"/>
    <dbReference type="OMA" id="YAFYELE"/>
    <dbReference type="OrthoDB" id="10342036at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="470" mass="53274" checksum="F258F43E76C4ACD6" modified="2013-03-06" version="1">MKDDAARLKKYYDGLIKTHKRLNKKVTTNTKVQNYAELKQNIDRLEHEIKAFQDAYGSFIKAQNNNFGEFSEEMYRSSHLKTRQGTEIPNYTIMNGQDRPGQPFQPPINTDENSQGFIGVPMEDKMDFAGDPNIKYDQSAQDFQMEPFMYGSSAPLLYNTYKGFPKTMPPRPNMNYPPNYGPPSASSAMFEQAMPPPPSRPEYSPMPGAYAPGISRQNFPVNPQAINPAVLQSYHMNAYSTKLPYPGYRPGMKSMAPVQKGYQPPPLGFKNTMQPNNEPMYSPYQYSPVIGNNSLLQPKKADYYRETKIEISPTPASATPSQPASGDGSMTPVCEVTSVQKVIDPSFLLASYRIPDVDEMCVNAKKFKTSDWSTNIEYFKKKWNLKFELTDAVKNQILDSCDHFFAQLCKKSINLAKISANKAVKRKHIEYAFYELENYLLPDSSVVLKNRAPNKKLLKQLTPHTGQNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW14</accession>
    <name>L7JW14_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW14"/>
    <dbReference type="STRING" id="72359.L7JW14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1839"/>
    <dbReference type="HOGENOM" id="CLU_059493_1_2_1"/>
    <dbReference type="InParanoid" id="L7JW14"/>
    <dbReference type="OrthoDB" id="2195201at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="222" mass="26152" checksum="3CDB9F536A7CF541" modified="2013-03-06" version="1" fragment="single">VTKLMFPFYIFMGTNISYIPELLCKNEEILVFDLDSTLYQTENYIYRRIEECAIKYLEIKFGEKKARNLMDSVSSISNSVLKGLLMTNSITYDEYHECIFSMVNYEDLIRRDDRLIRLLENIQKPLFIMSNGTKAHVKRVLEILGIEHLFRGVFYVGYDCGNYIRKPSIRAFMTVEKLTRAKKIHFFDDKQRNIDIAALLKWVGYTVDESGIYESLKRINTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW42</accession>
    <name>L7JW42_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thymidylate synthase</fullName>
            <ecNumber evidence="3">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="3"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW42"/>
    <dbReference type="STRING" id="72359.L7JW42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1340"/>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="InParanoid" id="L7JW42"/>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="9">
        <location>
            <begin position="52"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="336" mass="38576" checksum="B6F96B9A86D23937" modified="2013-03-06" version="1">MEKNVAQNGTGICTRCRNEMKNDEKENEQNRADGRHTADHNKNLYNGNVEEKAYLNLIERVIAHGIRKDDRTGTGTFTLTGQVLRFSLENNTLPLLTTKKTAFDIILKELLFFVKAQTDNKILTCQNVKIWNGNSTAEFFEQYCINRPAGDLGPVYGFQWRHFGAQYKSSSDNYDGQGVDQLQNVIDEIKRDKNSRRLIISAWNPLCIKEMALPPCHTMFQILILEEKVTLIMYQRSGDIGLGVPFNIASYSILAAMIGYMTGYAPGEFVHVIGDAHVYLNHVDALKVQLGREPYDFPKLYIRPKRKIQRIEDFELEDFELEGYRHHDKITMQMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWB7</accession>
    <name>L7JWB7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SMT3/SUMO-activating complex, catalytic component UBA2</fullName>
            <ecNumber evidence="6">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="4">Protein modification.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="6"/>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWB7"/>
    <dbReference type="FunCoup" id="L7JWB7">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2027"/>
    <dbReference type="HOGENOM" id="CLU_013325_7_0_1"/>
    <dbReference type="InParanoid" id="L7JWB7"/>
    <dbReference type="OMA" id="NCLDNNE"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="4"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="402" mass="45713" checksum="9E62A3CAD9F715A3" modified="2013-03-06" version="1">MEGNVLVVGCGGIGCELLKLLILKGVKRVTVVDNDTIEITNLNRQFFFTKTDVGKFKADVTKSYYEKMVSDATITSYTENVINTKFDLEFFKNFEIVYNCLDNIEARSYVNLRCRLACIPLVDGGSAGYLGQSMVFFKNECYDCTPKAQDQSFPICTIRGKPDNFTHCIAYAKEYAYTSIRETLSKYRKFQNVYKFLFPGNECGREAPKIVKKLMKYHAKLKKKNFPIFNKDNKTVVKFIYYMALVRAHNYNIAPENFFEAERIIKNIIPSVCTTNAAVASLMLISARKLLHSYFLTKNKKLIIKNSPSLGSNTCGICGTKWFVLYLNSNILMISDLLENLGLENAILAVDNRFYDAQKDVGELNVSHNSIMIVKSGLESFKFYIDVNSRCMLSIEECTFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWC9</accession>
    <name>L7JWC9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1986"/>
    <dbReference type="HOGENOM" id="CLU_918849_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWC9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="303" mass="35623" checksum="BBE7C61317860620" modified="2013-03-06" version="1">MRNGYTCGTRTNKFNDSYVCVYWRNCSLCYENNYLPINSYSMTIFNHDLTRNRDSISSLQRPKYELITTLISNLNSLEKRKKFVFSGETNLISNLKILPDNLMPDDLSIEMYSIQSTVFVLNMLNANHLKRLVLIVRPESIISNMFNELYYYFQALETLEIRAYDFKLDFVYSVFLRCFTKCGVKVLSITCQSPHESFGTVISQFLSLETLKLFIREIYTYNFKQLLSNDKFSNSLFRLCISLEIDENGYIPFLNPFINLEELNIRVEKTRNDNNGNFCTLNLPSKNRTFQQSSIVCLPYYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWD2</accession>
    <name>L7JWD2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1436"/>
    <dbReference type="HOGENOM" id="CLU_302720_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWD2"/>
    <dbReference type="OMA" id="NCITKDY"/>
    <dbReference type="OrthoDB" id="10392194at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="945" mass="111466" checksum="65833FF4FD41C87D" modified="2013-03-06" version="1">MLEKEVDDLIFNKKAKKIKPNENAVQYLKYMLRKCPIELEKDQKEMIELQNCITKDYQNDRRARSKSLEDTQRDALISTPVGTGTNAEHIDSVFKRVSTCEPLSPAIKILNDLFVILSKRQAADNEMVDEQLYKLRKEIKNLDREDELKLMHVMNMAKECELESYDYVLVEIMKKDVKVSRSGVIGACEMLVERMNRRSGGRTEENNRKMENEVGRGDKNGIYEEKRSCRKLEKGNNERIENDKNVENGKDVGNKKLESTYNVRYDELTNLILNSFDSFVALKHHGLTIPTYIVVMTQREFEVFADRRVVRECKRNLKMKNARMFYLKYVLLFDKHDIAIFRHCLSDDEIRVMARYGGQRKVFRNFYYKMVKRREWKRLWEFHSKMGGYECDRGDEPYRGPPHGLDTLEKGRITEKGLESNDGTLDDLICINCNHGRPCVLLTLKERIAIVNFIVKNSKIDITVLNLLSIFHYKRLRELCLESVGSDTAFNTQIFQFLKKRNEHNFYVLFLSDQDEVNLRSKDELMQFCHFFMKWRVERWISVNYRYFYVYLNGKNVIDTFIRLIEIVRAELRSNTANKSRTERLRTALTIDEDKIVAWLSLEKMRDKNNVMFYNRLLYLMQLLNIKNIPFLDVLAQYEPYVLNAGCFINYDKFMNRYLNGKEMGVKRLLIASGDERAKEFLGGLVGDLERYGLRDESGHGKENKIDGGCVKKDLGGESGHGKENEIITSISNNECLEDQDGSEDIELPRLHRLPPDYFEYKRKKTYALLITWLYAFPNDYAIFRPYVDDLVRDDALVEWLERFFIKDVIIKHIKYFLTKPLLYLNVLIKATSYKLVLASNSVPVIIKHFKAPWFIIRYEDILLDLNFELESKMLPLFCKFLKNKSVLISKFAYRIDRDHLFIVDELKALKCRKIVVKCLKKVMYECEAELFEIIDGLIDETRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWJ2</accession>
    <name>L7JWJ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation elongation factor 2/ribosome biogenesis protein RIA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWJ2"/>
    <dbReference type="STRING" id="72359.L7JWJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1327"/>
    <dbReference type="HOGENOM" id="CLU_011666_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWJ2"/>
    <dbReference type="OMA" id="CSARLCD"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="850" mass="95654" checksum="3AE3777A36D3911F" modified="2013-03-06" version="1">MFIVSVVAHVDHGKTTLLDSLLSYTHVISRRSAGKLRYLDTRNDEQERGITLKLSFFQAQRFIFIDTPGHTDFHSLTECSARLCDHFIFIVDVNEGITPRTLALLALTKGKRCTLVLNKIDKLLGCPELVPVVLGIVQSMNACLGEHCFEWRRNNVVVCSGTGLYGVCYGVFGRIRADSTLKDALVFLYVMSDGDGRTGRRRQMMVERLESVGVVGKELKDVCPLEVALFNSLNDAVGRVAVDGVVEGGVGFDGQVAGEGGIDGVKNGQEVDEEGVDKGIDGVEEKNVEEGVDKGIDGVEEKNVEEGDMEDGKEDTNITNTNTNITITDPITNVKLKDKHYVLPADHRTFLSSIVPEEQLCSIIGITTYAVIHENVLLFITRLFTNIHQGMVLFTNTQDKSKQCTITKIYTFMNDRLIHTKSAAAPTLVALQSNFYRNSILSTRALNMHANLLNTQPFYTKMIRPWCDMKERIRMLSYCEPILRAKVNRYGEVELLCEGRMHFEKIAHDLRYEFDEVACCDLVCEGCGDEGRAEIDVGGLSVCLVVGPSDCKENYLHVECYDCDEVGGCNGVGEGRGDEGRGDEGRGCNDNDTNNNDNNDNNSLISTFDSKLCINATEETKNTEEIEDNNDNTNDNDTINNDTHDNNNNGNDNTININTNDVKEPVLTTRALKKEMMNVINVFIKKGPLLHEKVLYTSFYARITRTGASHPTPPDLFPKLLKTLTTAYNNTHPIPIAFYYRCKLSITEQYVGKCYKLLNKYRFKMLSNEYDGTNRFFVVEFRIRRCFYNDFSDELKSVTRGTFYVYAWEEGYVRYEGVWDDVVVGERRRKGMGDEEVIVSEPEKQRTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWM0</accession>
    <name>L7JWM0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="14">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_1155</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="14"/>
    <dbReference type="EMBL" id="JH993908">
        <property type="protein sequence ID" value="ELQ75878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWM0"/>
    <dbReference type="FunCoup" id="L7JWM0">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1155"/>
    <dbReference type="HOGENOM" id="CLU_000315_20_1_1"/>
    <dbReference type="InParanoid" id="L7JWM0"/>
    <dbReference type="OMA" id="LMYFQMT"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="251"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="959"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="772"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ75878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1107" mass="128818" checksum="CE523DD9C6B15CAB" modified="2013-03-06" version="1">MTSNKPRTYFLRTRTQSMLADHYDTVPHPKVSECALCSLALTHHSPERILLEYFMNQFLEQERKMVKRKVRPNIKAVSAYRAYRNAKMASLKKMASVCARELRRALMRTGKTNPCLKGRRSGKGFNALTRGKKMKRKGEKEKKREDRKEEEREQRKLNYLINQTELYAHFVLRGEHERLKKTKLEWNDDDGAMKEMDEQLAQFKQEEKKMESGGNETMTIKNITRTQTVPVLKHFKANLKEYQAKGVCWLINLYNQGINGILADDMGLGKTVQTLAFLTYLAEHHNKRLFLIVTPASTLHNWETEIKRFNSNFKINLYIGTDRNVSIRRIPQPLIVLTSYQLIADRKLKRIKYDYLVCDEAQAIKSNKSRRWKNINELRCNNRLLLTGTPIQNSMQELWSLLHFIMPGLFDSHTLFLSWFSNEKSVKKEGLERLHSILKPFMLRREKKDVKNELGTKTEKDVICIMTPLQHALYERVNKEKESENMMMQLRKIVNHPELFMHRENGTGLYCGKDKHVLHLSRRSKSMYRTCLEMMLNEVKTVNSMYGNIRGIKSNDNRRDSTNDLHSNVSTSTASNSCERHSHPANLNYHFVGYKNNGAVSGGVYDSYVEDMSSNGDNNEIDYNNNNNDNNNNDNNNISTISANTPHINSDLVLKRKVEQKNDRDVFKRVRLPDYVEDCTYGISKCCSKDLVRRYTKSDVHLNYLEGLETYSPMHSNRCMVERINGMGVKRCKYNQVNKEFYYTMGGTYEVVTESKYYEKEYNKENTRINVDKNKESGKGVGRGNGRKGKRKNDGNDMVKEIDEDTNGRDGDERIKIPTSSLIKDCKRYGCTEEGKDGDIVEIEGKNQHVRLMNDERVKTGADCKNGVNTNDQIVEIKRCAGANKNYYDHKMMNMLLDDLNYEQFKFLRWNRLLYAQRLYFRGVVCNLVRRAFCSVVNNNNYVMVPEINLVKESGKLIVLDSMLKQMIGRRVLIYFQMTKMIDLFEEYVKMNNYSYVRLDGGVKVSERKRIVNKFQTEDIFLFLLSTRAGGLGINLTKANTVIFYDSDWNPTVDLQAMDRAYRLGNTEDVVVYRLVTANSIEEKMRITAGMKEEIHRLVIDGGEFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWN5</accession>
    <name>L7JWN5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1372"/>
    <dbReference type="HOGENOM" id="CLU_1595719_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWN5"/>
    <dbReference type="OMA" id="YEECANE"/>
    <dbReference type="OrthoDB" id="10384787at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="19622" checksum="F5C67CC1AB615DAB" modified="2013-03-06" version="1">MALLLYVTNPFPGHKTNFVDFLKRVTKTTRVRVFQIGSTILPFYFLVFDSRNDLQAAVNILDIVKRQFIAKLEFYTEQNIKIQNMSLSKGLSAVIKEYEECANENAVLDKFMSELRGDENKDPVKEMSAIYEKLVVNWMEQEKEIKDEFLKRLRIIESKRKKTSDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWP7</accession>
    <name>L7JWP7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein involved in cell differentiation/sexual development</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWP7"/>
    <dbReference type="FunCoup" id="L7JWP7">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1387"/>
    <dbReference type="HOGENOM" id="CLU_039962_2_2_1"/>
    <dbReference type="InParanoid" id="L7JWP7"/>
    <dbReference type="OMA" id="EKVYTWI"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="270" mass="31118" checksum="0075406A659187BB" modified="2013-03-06" version="1">MVSDFNHTIKKSLAEKDKSIYLKKLFLYLEKNPSSSYEFWTVDEIPFLILQELITPFSQLSLPEIENKSFSDVITVLNILQIIVTDRSVREDFLNAQYPFYIYPYLNTNSLNNQFESLRIAGLGVIGQLLKDDDKKTALYLQNTEIVPLTLKIMDIGSIVSKKIATYIFLKIIGSDEGLEYACQTFERFIAISVILNTMVAQLLENMDKNLLKSVLRCYVRLVNQDNVRISYATKPPEALCSREMAKIIEDDKDIRELFSLFKKIINSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWQ7</accession>
    <name>L7JWQ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993932">
        <property type="protein sequence ID" value="ELQ75730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1316"/>
    <dbReference type="HOGENOM" id="CLU_1125203_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWQ7"/>
    <dbReference type="OrthoDB" id="10469772at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="247" mass="28419" checksum="56FAD9C08CE54F96" modified="2013-03-06" version="1">MLVKFCPSVYSLIYVLVCECRYSDYEFSSTGESIYSLTPADTEYVDTLYSDIRDYGLKAAEPSSRKILRVEETQPFDYEPIVFEEIPQVVQPKVVKLDLKRDYKTRSNKYDLFFKKVAREGTSTTPEYRANRHDLGSILSELKDKILARIEKGLKKKYSSKLWAVYKAISGIVDRLDDSVGTSKWKRLKLSKLLYLVKDFVDDAVELVKMVEKVRKYDADELETFAEGCDALINEATEIQSVVEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWT3</accession>
    <name>L7JWT3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dopey, predicted leucine zipper transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993907">
        <property type="protein sequence ID" value="ELQ75889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWT3"/>
    <dbReference type="STRING" id="72359.L7JWT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1153"/>
    <dbReference type="HOGENOM" id="CLU_898849_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWT3"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOP1-like C-terminal" evidence="2">
        <location>
            <begin position="110"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="310" mass="35863" checksum="2BF7916024435E84" modified="2013-03-06" version="1" fragment="single">VKGVMVGVYGRGRSGDSYDRGRSNDKGGDSYDRGGRHNPITNPINTNNTNNTNNIDNDCWSCNDRQSIGLDTLIYHGIGLKEYFEYFLESTSFFKGTKCALVKKSVLLQQILPERIDELLSRLTSNFFTSREADSLNKAAVLKKISFFILSHEFEAFSAHLPSIIPIINELIEYPKPVKREIYTLISVIFFKFHHNNLSALFPIYFSEVENDTLLECLRSLEMLMLIGSKETVEFRWYISCTGDENTLFKRMLGELYRDTAVRPYLDRLPDTRVPLLGMIRRRFCVVLRVIMRCLMRECGLLMRDWFRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWY6</accession>
    <name>L7JWY6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1860"/>
    <dbReference type="HOGENOM" id="CLU_394930_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWY6"/>
    <dbReference type="OMA" id="CVENNKF"/>
    <dbReference type="OrthoDB" id="2196329at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="698" mass="78892" checksum="2437CC8944B2E6CB" modified="2013-03-06" version="1">MENKILDLIKNRKGARNDSSLSDLIKGIKKDAHTTNDNKTEEGVRTDDRADTLLNLDAGPVCCPLDPKKENLPDLMIYKYYVNLAQLSNFQIKSKDSIVVYFNNDVMYVCERDGRGVQIDRQTLLKSYKSLLDQDGDGEEVLEEHADKDVSLYDVNHKYVVLRIADDVVFYEIVRGDELVIREGFVLPNAKQVVLFDDHIIYVDDRVMERRLDGGEERVLLDENVEMIFIVEDIVYYKVQNKIYNKMNSKMLEGNILIGMDNNILLRNDECYVLLDNEYVVQDRMTIGENAFVLDNLIGVLRGNVINWLCVENNKFKVYGSTSIGSNATVSGDKKDNELFLYIIKEGPGEEDTGKAVINESADKATKADVKNGTRKVGKKAGPKGPVGSPVGDKNGAPQKSADKIFDAFEQAQKTQAPAKKTKGPAKKEKADQNDTQSETDMEDRFERISINESRTDVLEGNTDLYSRVEALIEGLFTRFDAEMKKRENNFKKKQVALLTGISEQMNKCFNGLVEKLTRADKSVVGKKEMLSEFRKMFSDLLIPCVEAGIDEMRLQVVGEMRRMNKEDSRVESLLSSGKVKEACTCALEGNDDDFDTFVNIVDSDALKLLSARQCVSLIDRCSFMLDNGDEKKTEIIKKILGIIDPHEFEESDFAVFKRVLKRLEGVGSDDKLLGLLVETQKHFFNKAMTMKQIRPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX02</accession>
    <name>L7JX02_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1202"/>
    <dbReference type="HOGENOM" id="CLU_1086645_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX02"/>
    <dbReference type="OMA" id="FWYISEN"/>
    <dbReference type="OrthoDB" id="10357083at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="256" mass="28766" checksum="F907DAEF738DDF66" modified="2013-03-06" version="1">MFLFFAYTKASILADILMETKKRVGENTSSGLAVLTIIVGLFILVLGISFKRISLTVLSSIFLTQVFWYISENFGEGYIFAFKLPRSYSGKAKEVLEFLEANKLRLLIFILIMSFIVSTVIISFIKSVTFLVLFIATAVAYTEGFHIKLLQKAGIDEPLVRYLLYAAILIVIVLLYIKIPEFLLAGLFCFIGSLMVTYGIDTAFKLEWNSLEVFSTSLRDFNTSINMDNKASVTMMVCFIFGMGAQFIQVLRIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX33</accession>
    <name>L7JX33_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX33"/>
    <dbReference type="STRING" id="72359.L7JX33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1032"/>
    <dbReference type="HOGENOM" id="CLU_1653480_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX33"/>
    <dbReference type="OrthoDB" id="2188412at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="132" mass="16017" checksum="45252E7FA58B8030" modified="2013-03-06" version="1">MHAQSFPFACLICQRNYPSEKSLNYHKIIHTRPNYYCEKCEKSFFYSDKLKKHLITCGRQWTCSCGRVFVRKKWYDRHMEEHDVSKYLSEKKIIEIKPTALKYIFKCRHCKKGMKKRKTLEVHEQTVHKPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX94</accession>
    <name>L7JX94_TRAHO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">THOM_1664</name>
    </gene>
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        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1664"/>
    <dbReference type="HOGENOM" id="CLU_1983124_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX94"/>
    <dbReference type="OMA" id="QYLCGNS"/>
    <dbReference type="OrthoDB" id="10377338at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="126" mass="14589" checksum="EC975DE58770C7D3" modified="2013-03-06" version="1">MSGHSSDHVKKRNRAKKSDTSVNKPASSVMTEYTQTEAIFSGNFDFLIFKMLNILTANDKPVLFIIPPLILVLLNFYFDYFNPMHLSFTVFFLYQYLCGNSFYTFVTNALVYFLVVGIATFFYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXA6</accession>
    <name>L7JXA6_TRAHO</name>
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        <submittedName>
            <fullName evidence="4">Zn-finger</fullName>
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    </protein>
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        <name evidence="4" type="ORF">THOM_0938</name>
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    <organism evidence="4 5">
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0938"/>
    <dbReference type="HOGENOM" id="CLU_903687_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXA6"/>
    <dbReference type="OrthoDB" id="2189995at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="282"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="308" mass="35245" checksum="3C07DD830FB88A0C" modified="2013-03-06" version="1">MKNDKWKMCEDGESDGVVDDFMDGKCLRADDVPGRTSAQDVMCDSYSVVRTGVSGTKRNKKHGSTGGHIGGVSAAEERDIDKENVVNNGWSEQNDIIDRGLIDNNETGTENNLNFGQRDQSDVIQDAVKQQTGVLHGTHETYNNDKSDSSQEIHHSDDVDVPRNAVTGSDCRGDDSAVENIYCNESANLVSTDKGVRTNSMLLKHGYQDRKFSIIREMQSYTFNGISKYEIELFRYFLWKIHRRDINTHNVAAYEKKTENGTCNNLYRENWHLAIHESDREYKCNHCDFTYIYRKCLITHMKKRHPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXB8</accession>
    <name>L7JXB8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1064"/>
    <dbReference type="HOGENOM" id="CLU_3377385_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXB8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="34" mass="4338" checksum="4DE95D816921F950" modified="2013-03-06" version="1">MLWFSHKRCLWWVEEQLLFKIKQIERHAINGKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXE5</accession>
    <name>L7JXE5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXE5"/>
    <dbReference type="STRING" id="72359.L7JXE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1615"/>
    <dbReference type="HOGENOM" id="CLU_1451026_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXE5"/>
    <dbReference type="OMA" id="QYSHMNT"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="187" mass="21793" checksum="F8EA7E0D508DB5C8" modified="2013-03-06" version="1" fragment="single">VFRDAQREEKELGALREEVEKYVHDFRCVSGLDVSQSVNDALEEEINVLNERIVVLEEKKLALEEKRNEYANHASYLEESIKHLNGRLLSIGKLYLEKKEMSDLEEHRGRKEMDKLDNELMNLTIESNNSILLSEQALQRVKIQMDRVVGEIRNEQDEVSKEIVRFYGMMSNELENAVAVAKEIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXF1</accession>
    <name>L7JXF1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993889">
        <property type="protein sequence ID" value="ELQ75995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1035"/>
    <dbReference type="HOGENOM" id="CLU_1187494_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXF1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="234" mass="25978" checksum="5B43CEF614C48CC2" modified="2013-03-06" version="1" fragment="single">VSDGVGKREEQEQSEVDYDSSAFMEIECELTNTCLTIEVAKGCLENTVLLTINGGGKVKMNERNLQDSVTNDEALSYSSTETIDEVHDSETSSEVAKGESTNSNHYTSITKEFQLTEHETCQSSSGKFVVDGKKHIVGRGPGGKFQFFKQPGPENCVLEQEQKMSHRNSESKPHDRNYEADESDQSSTGNSTSTMYQLRIGDRDSDTVRDTQYGEHKVSNTETYGNNDIKESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXH7</accession>
    <name>L7JXH7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1023"/>
    <dbReference type="HOGENOM" id="CLU_888600_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXH7"/>
    <dbReference type="OMA" id="MRDNQEN"/>
    <dbReference type="OrthoDB" id="2191051at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="36749" checksum="1918ACEEDCFA70C7" modified="2013-03-06" version="1">MRDNQENVFFLEDITLEEEYHLVFPDETKNTKKDKVQRIFGNKLLPTSQNLRDTDFTLEDGRSYTDNSAELVMLALLNNKIFYNFIEDLDEKINRKIVYTPFINSLINYLKDYYKNNFRDFNDDFMNVYRMICKRIHDDLVDTHFFEEENWTSKIKKSYKSEKKIFEKYSPIVEIFHGKYEGQDGRTFYKIYRDHLDITVKEGTNDISGSVRDYFQSTNIKVNKYPLILVLKFENKKKLGVQDILTIERTKYNLSGFITYAEPTHKAYLNNHGKWLMCSDGSITSVDIDEKDKYAIFIAFYQIDRITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXJ7</accession>
    <name>L7JXJ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesterase</fullName>
            <ecNumber evidence="4">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="4"/>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXJ7"/>
    <dbReference type="STRING" id="72359.L7JXJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1232"/>
    <dbReference type="HOGENOM" id="CLU_963455_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXJ7"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="330" mass="37665" checksum="F48912FA7D6FC828" modified="2013-03-06" version="1">MSFFDLVKHDDNTFITSELWSPFPLYPAFGGHLVSLSLLAAEMYADARPSSIHTYFLLPGKIGTPMSFEVKFLREGRTTKAVNIRGYQSNELIVTSDCLMNNELASTVFYKIPIEIYDDVYVHISTHFMNLLSPCTTNALLKSEVHKNSSALESGKAERQRLHHGVNEMIRMVDENYKKLEKYFSVYIGKPNGTKRQFKIIFHDKYHDFNVLMAFISDLFLCNTSLAWIKQRYERRMNGNDSDHSNVKDCMLDGKCNSDTCIDLNSVVKKSLDHKIHFHSNKFYDELIFVTECQLLGEKKALFEGKLLGPEGALVASVTQEGIITVKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXM6</accession>
    <name>L7JXM6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1554"/>
    <dbReference type="HOGENOM" id="CLU_1887317_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXM6"/>
    <dbReference type="OMA" id="CLMSGKF"/>
    <dbReference type="OrthoDB" id="2189745at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="137" mass="16100" checksum="03C02A9ACE08A059" modified="2013-03-06" version="1">MQYNFSKDTRFKQLPENIKKRLITLYNKTKQRKEIKSEELDTSMFTALSTKLTNVHSYELTKNYGLLVGAGEYYKECREKNSKMDATDGRKELEDMCKIYNESIGSRDVLGEMIDCVCLMSGKFLELKRNRNEKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXM8</accession>
    <name>L7JXM8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1267"/>
    <dbReference type="HOGENOM" id="CLU_1190616_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXM8"/>
    <dbReference type="OMA" id="MIMNDED"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="233" mass="26009" checksum="CA2CAD7DB6D35646" modified="2013-03-06" version="1">MVANVTNKNKKEISDDEDNELKTNELKDEKEGMKTPNNDEKSDNKEKNELEKEKALLTAKDEKVERQNNSMLVNEDIGKGDSSSSKVEDKKGIESDSSKVEDKKGTESDSSKVEKKSDSINNEVNENISSNKAHKENEKKKNNVNRKNDNAINFIDTSAVGSEDNNIGPTSDIIHNGAKNANKYILGASADHMKPKDKWNMIINEQNGSSDGKRKNKNGKEQSLKDSKRNLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXN3</accession>
    <name>L7JXN3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Nucleotide-binding, alpha-beta plait protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0861"/>
    <dbReference type="HOGENOM" id="CLU_2575551_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXN3"/>
    <dbReference type="OrthoDB" id="2186698at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="9241" checksum="E49EAC7E7945406A" modified="2013-03-06" version="1">MNESSDTNLSNLLKTDKRLRNGETVFLGFVGFTSPDFAEKAMEEKEILVLKKPVKLTYARGSRQRGSQYFSKTRLHISGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXQ7</accession>
    <name>L7JXQ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Drug/Metabolite Transporter (DMT) Superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993859">
        <property type="protein sequence ID" value="ELQ76238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXQ7"/>
    <dbReference type="STRING" id="72359.L7JXQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0799"/>
    <dbReference type="HOGENOM" id="CLU_934466_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXQ7"/>
    <dbReference type="OMA" id="PYILPLW"/>
    <dbReference type="OrthoDB" id="2191964at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="298" mass="34820" checksum="4ABB4D9544C1266B" modified="2013-03-06" version="1">MFMATRMVLLVLGISVYIICSTYKIHLKPEIMPYILPLWFFNLIIVVVSFMFVKKRKYYDFYICLLSVMLVVQSYYSWMNIKKSKVIEAGIAETSSIIFMCILSRIFMKTRITKPRVFAMLITSFGLLMPILFSKEETNINFSTVAGHVCCHFIFCIINIIYELKIKAKITSIWSFFFTSNFFCLILSSFVLLYELLDKGIDLRRVLKDIKVYIIISSESFSILFAFALIYMFLPVERTFLKLVINITAGIFESAVLDKNLKIWDVLSLVIVSLGVFVYNIEYIRRKLKELRRRSNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXS6</accession>
    <name>L7JXS6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993913">
        <property type="protein sequence ID" value="ELQ75856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1183"/>
    <dbReference type="HOGENOM" id="CLU_240170_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXS6"/>
    <dbReference type="OMA" id="MNESNGM"/>
    <dbReference type="OrthoDB" id="10562537at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1560"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1571"/>
            <end position="1584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1724" mass="191525" checksum="9882CC3538B26258" modified="2013-03-06" version="1">MISIEDRKSVKVKLYNVLSRSPCFSECGKSEVLRLCGVMEEECFSISNSVEGYLRSINEKINIYARMNDRCMNEGSRMGGRSSEHVNGQRNMRMNENDARMAECNMSERNSMRMNENDARMAECNMNERNSMRMNENDARMNTHKINMNKHAAMHLRNGLFGVSSHRSGPGQDYVATNGPVNMDNPSIAYDMNIHRSHDAPTHSYNNARFDPSEHAMASMNADVNANYAHKRALVNLKTKNETGTAHSISNAHNTNPQMAQPYEPVRRENDPGWSDMHENRSNTRTSIYNSNKDQYEQSMRNIGCRGSTRPYSYDTPPRNNAYHEFSNNVLDAKGQDMPNNGKKRVDNYAMHENGKLVDAAGPCSTDLNYSSVGSSHGRLAERSSCASQRYTAHADNTAARSPYNTNRRAEGFSGQPATVPDQRTKHAVNHFYPFAQNGQHPNRSVPNAQFACVRDARPEKRPFTDKAVLFQKQSENNLNTAKTKNKQKKEMSSNKETATSNDTAADVPTGRNTGAYDSSHFTVMHADASRSGSMTKQKRENEKNYVPPEKMQSDTNRQINSCTDKRAIDGMRMTGTHASYNYGRVGNINAFNDSTTGDKRSINYSNAYASIDYQKYAYENMQKAYLDANHASHENKMYKSGMNSINSDVNRMVSVKAGHGEINRSSMGAGHSDANRACDAFSSYVAATNGQASSSGQAFQHNGEFLRHAQHNTDMTTNTAYTGVISPGTNFGFKNVKQGSTAYYDNHTNDVNLRAGYTDNHTTAPSAGAVQRYTYKMVQPSVDSAQTMNKHPRQNASYQRPAAHAQHHNNSHLGRTREVYPNGAGFSSRTPYTGEYPFASHGTYPNGQNMPINANIPSPRNAYANGQQSDRMAAAPTPNAYDMPNQRSLGTPVHQNHKNEQLHKNQTITDAARPNSHLNSTRVISRVPGSANVKQKDYLERSTCNSVLKSTYYDASVTNGRDTNMYMNGGQAFNSERFTSGVQYAGDANTVRCDTNGISRFASPNGSLSTAQYAAMNGHASFNARGTNKNMNNYVKNGINAAQQFVDNAGLLRVKNTYEQQPKNSLRTITDSILNGAFASRTRNNGGTSAPMNSARAALNTAMHESVGHKSINNVQPILENVQEEIRKRIRLDPMVNDNTVLNGISMMGYSKSQRVVSGKESSSVEYIKRMSGNPSYLAGSTTSSRVTSYDRPVNRYDNSFNARTTEWHSNKNVNMNLCSLKELESGKILRNSSINHSRKSRTDEQADTTKNALRSGDTDDNGGFERMMTSNAVVRERSNDDNTISDGVMSRAGDVVKNRSSSSVGNTIHGVVMSIDGNTINNISSGNTINNIGNGVKKRTIDMVNTIGGAIRSSDGSTITNINISNGNTITKAAVKRTIDMVNTTGVVKSTLDKVCNSPVNNVQVVNTSNGNTPTENATASTASMSNASSVGNNYNGHTTYTGTDDHNGINATLYGNYQQSGVQKGGRSTVGDKNGERVLDRYRGLGITVESKECDVLPCTTENEMSIKRIKVEVKKMSREEMIKKLIMDIKTVKSNDELMDIIEKLRKYFDEREDNSKDGNEIVTADNDNRAKEEVNEEKTAPTLPEEDASCSSAKINFFAINTEEDKSMFKEFKDFLKMAQSVFIAYDDKIKQDLTYRKYKEVSRLVRESNSDQEIEYFREVIEHLKQNVEKVLEEHGQTTEFSYAYWINNSIAKFNKRLKKDHSFCIELGKSFSKVLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXW7</accession>
    <name>L7JXW7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1146"/>
    <dbReference type="HOGENOM" id="CLU_1005387_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXW7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="277" mass="30647" checksum="8BEF01FE9819CE68" modified="2013-03-06" version="1">MLRKKVMISGACMLFKAFVGLNCGWLILAFLGSLLGDESSSVEYSGSEGLLKLSNECMLDRREAVGPLLAVMRAAKDAQMPKVRGGLSLPSDEDGLEWSNNDADLTLTESKGTIKMKDHRNGSHADRRYQTIGGEHIVGYKDSQKAMWLNGDNNTRSRCYVSAGKSQCDQVVLGGTDGCRKEYHESISNDTGYETAVSDADTSDTVCGYGRLYYRQNPCILGVDVYYDAVSGVAPFYKTSPRSNVPVVSEKKSYHTWDWRSLVHKLKKCLHAKFHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXY9</accession>
    <name>L7JXY9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1428"/>
    <dbReference type="HOGENOM" id="CLU_863780_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXY9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="322" mass="36768" checksum="AC30C2A3FE3521F3" modified="2013-03-06" version="1">MTNNNMLDVGQVGNAYGDDHHTDELEQNDDQNVNINMTSNEDDYGYEDYPEFATYTVKTPKPFCDTCNHDSISGWLIKRGKNTSDCYISAKPAKKTTYSISDATADCNISSPLQYTCDLGFTYGPMEFNTVGGEIVPKHSIFKLKCEEQPGIGYYNIKCERDSPQFNSSSKLRTKVRATCPESPNATDRYCSFEDKTDDSSLIKLGDVILHYDQLNEDEKFFYGFVQHENVASNVPTTTHLASISEPAYNSLDASSPTGAERISVTRRDLMEKCMIAGPVFVIFAIFIFIYWYFWKRPRKSRLNFKRHTEWKRLRDTDGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXZ8</accession>
    <name>L7JXZ8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Pyruvate kinase</fullName>
            <ecNumber evidence="4 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_1103</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 14"/>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXZ8"/>
    <dbReference type="STRING" id="72359.L7JXZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1103"/>
    <dbReference type="HOGENOM" id="CLU_015439_1_1_1"/>
    <dbReference type="InParanoid" id="L7JXZ8"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 14 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="15">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ75936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="309" mass="35164" checksum="16FB3D326221BB8B" modified="2013-03-06" version="1" fragment="single">DVLIDDGKLRMVVDLDGDEIVCVAMNDHMVKPNKAVNIPDMKMDKSVPTEKDKNDIFLGLKNKIDYVFLSFVSNAAEIRKVRDFIRDMNGHMPVLIAKIENKEAIRNINEIIEEADGIMIARGDLAVEIGIKHCFSAQKMITKKCLVMKKPFIMATQMLESMTEESTPTRAEVSDVGNAVLDNCDCVMLSGETASGRHPAHVVRTMKTIISDAEFFKYGEQWKKSRALLIFMHHYSDHVIELKYSYKVPLVVISNDESILRRVGHHAGFFCFKMENDETREQTIKRIKQLCGIDEYEWIVVGDENDCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY27</accession>
    <name>L7JY27_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0844"/>
    <dbReference type="HOGENOM" id="CLU_112151_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY27"/>
    <dbReference type="OMA" id="CKFRDEA"/>
    <dbReference type="OrthoDB" id="10341723at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="157" mass="18788" checksum="26619CC944F0098D" modified="2013-03-06" version="1">MLHRPFTKDNALRFLEYETKLDRYLRHKQTTNPFLDVLYKRVITKFKDETVFTMFVQHLVGTHTVARNVDKHSLNTLKTFCVTYLKRNRTLYLTLLMANTFYRIGDVNTGRRFFVDAMRMSTDKSIARMMMDCERMCYCTYHTNSSKDIIEALKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY30</accession>
    <name>L7JY30_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993895">
        <property type="protein sequence ID" value="ELQ75966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY30"/>
    <dbReference type="STRING" id="72359.L7JY30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1070"/>
    <dbReference type="HOGENOM" id="CLU_105931_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY30"/>
    <dbReference type="OMA" id="MERMDIF"/>
    <dbReference type="OrthoDB" id="2192592at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="159" mass="18278" checksum="D89251B411A6D857" modified="2013-03-06" version="1">MHKIELEEQIIDKLEQIDQTFSSINKVLKDINTKIQQLSQTTTAITTNSSPWLNFFSTDTPSIAPEDHTSSDATHKYDVSVDDGLHSFDVEELPETFSSKHVRMIYAYVEGRGQVGLEEVYGEFGDVEVERMDIYIEMMIFKRFLGCRNGVLYAKRRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY75</accession>
    <name>L7JY75_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY75"/>
    <dbReference type="STRING" id="72359.L7JY75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0766"/>
    <dbReference type="HOGENOM" id="CLU_634918_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY75"/>
    <dbReference type="OMA" id="YHRIYDE"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="209"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="397" mass="48990" checksum="A4107619C758ECFA" modified="2013-03-06" version="1" fragment="single">VQVGLKDKWTSILKINMGIPYRFVDKIAFIEDENLEYVRRENTESDVFYFSNIESNLKQIKRIRGMKGTFLIKLPFAVNNDYLDIVEILKSIPNDIRFIDFYNMRCVRSIINDFFRRDKFYNFLLSREYIEAIIIQDLSTERKTKYGIVFEIMQHFFVNNLISITKDNTDTVKDVCPRYMQRMERLKLLRNLRTIKCTWFRCYVYHRIYDEFVRTSDRSLLRDTYTYLSMQIYNTRWFGVKITFNAGRGFRRVVDRTVIKFTKLAFKRLFARYYYREIYDEEREEIRYISLIFQDFPEPRIYLKIEFRRSIRRLIIMNRDDIEKWLNEQRDGMNEYEHFFQCFFNNNDVYYVRLEEVEEIYRIFWFFYNRLYGFGVYAENAKTPNLLYQLANDNFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYF2</accession>
    <name>L7JYF2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1290"/>
    <dbReference type="HOGENOM" id="CLU_706020_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYF2"/>
    <dbReference type="OMA" id="MIDAFMC"/>
    <dbReference type="OrthoDB" id="2192365at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="357" mass="41743" checksum="F7316C9510039C2B" modified="2013-03-06" version="1">MPNQKNHKRTPRNFDNFMTEKERNYVSSIFQKNILRTNKIYNYSMFYDEKPEHANDKSDSAGEYHFTVNKENNRKLINELEDLRLEKSERFDAREDSKPGDRKNGDGKSAESLSRPARHGRAHKISFIKSVKLPRLMMDVDIPVFDDLAIKLKIEAMIDAFMCQKYVIKESNLNNLIVQNSERMGDFFKVAKFQKLVKEIFESGNEGTKKILLLEMLRNSQYIRANENMSALLDYLVAYVPNLSVEEIRSTSFFDNFMFGQTGVLLATLLLINQETLAPHFYQHLRMRMEYLISNELRYVWRFLALMVINLGDRDKKWIVVRLKDKILEVAVSNNMDDISDMSLFLDALGLNSEDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYI5</accession>
    <name>L7JYI5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0522"/>
    <dbReference type="HOGENOM" id="CLU_991064_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYI5"/>
    <dbReference type="OMA" id="SITFWFF"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978891" evidence="7">
        <location>
            <begin position="22"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="281" mass="32351" checksum="C5E4658C00E82A3A" modified="2013-03-06" version="1">MFIFTFRVLSILLLLYSLSDASIPKELADHFNTQKGGRNQFLTIIGVQLTILTLLLNVLKYRRAHNFIYPIALATEFTISITFWFFYFTNPANLMRPIPGVETLLPFYMDIVYHLLPLLALIVEAFVIDLSAISLSPCTFAMVPIAYYIWAAYLSKSNGVWPYPMLDNMSSTKRMIYFGYYTLIGIVSSQIFVSVARRISRHCFKAKNDEPRQNVPENEDEQPRQVEQDVSSEDEQPSHVEDVSNEDEQPSHVEDVSSEDDQRSHTQEQSTPNTEQEENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYL0</accession>
    <name>L7JYL0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0630"/>
    <dbReference type="HOGENOM" id="CLU_2607712_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYL0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9317" checksum="BE72E6BBCE2747DE" modified="2013-03-06" version="1">MIASLDLLIKTFFGSKASDQRRVCSNYTRLSSALEQWHICYDLEIRSFVSSQVSYEYELVDLTISDLSDLWMIRFVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYQ7</accession>
    <name>L7JYQ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0313"/>
    <dbReference type="HOGENOM" id="CLU_2110651_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYQ7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="115" mass="13384" checksum="B656E938E29F1C07" modified="2013-03-06" version="1">MYFYTGQYQINITDPLMAVDPHSDRIQNLIEQIKQNPSAKQSAIDKTIIERACSFLHINDLDALIQNKKIDKSRINKLLRIKNDKIYEALIGFGEKESTLWDDDKIDDLIRTMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYR7</accession>
    <name>L7JYR7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYR7"/>
    <dbReference type="STRING" id="72359.L7JYR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0293"/>
    <dbReference type="HOGENOM" id="CLU_761148_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYR7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="364" mass="40224" checksum="A6E0BEED927A8890" modified="2013-03-06" version="1">MVESREVYGHSDASVLTMIQSKGVGDDGQSGKEESVDGESVEGYNGELMTENAAVKDVSTSVGEVSVVNPLESGSEQGGTPSDNEKRKEARDGVVSECVEGAYQNGVVEEGAISGVCAKTENEEVPCRSEELRESANDGNGTQSRDELLVPSLNLKKEGPDTKDAPALSHQKEVPEPVPSARKTEQGREAVHDEKDAKEDERASIENFVNETASIVNRTPDIANEWIKLLKEQEIDTVEDLKLLVEEDWDALGLPVFAARAMMNSLYGKDRQPVKEKHQTTNTSIPEYTDDLQIKDFIVDVCTLARKIENASLWEAKLTNQEIRTVGEFKSLHSKDWNKLGLSVFCYRILKNILNRKGRLPFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYR9</accession>
    <name>L7JYR9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0323"/>
    <dbReference type="HOGENOM" id="CLU_2185771_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYR9"/>
    <dbReference type="OMA" id="FVRINDM"/>
    <dbReference type="OrthoDB" id="10385361at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="12852" checksum="A0BEE3AF4DCFDED7" modified="2013-03-06" version="1">MIPLMKKRTSTKYTTHELLHMKRTVDFYVKELSKISTSTDLLRGLLKQRNVSIKICEYALKEIVINGNFFVRINDMHYVNGDMSEVAQVLHLKLNYIGRKVKELLRIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ97</accession>
    <name>L7JZ97_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993877">
        <property type="protein sequence ID" value="ELQ76082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0945"/>
    <dbReference type="HOGENOM" id="CLU_1807580_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ97"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="16472" checksum="9B9BEB91609623EE" modified="2013-03-06" version="1">MPKKSKELIDKMEAIHVSPFGSSSEYFSKSSLREDSINSSQPRRFGSLDQDKPIEPEKVVKETWYATIGFKAYNQLFTWPNNAEKPFVKRSILLADDTGIEWTNSSKELSTQNSCTKAYDQPFTWHNNVERPFDEVIPNMNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZE2</accession>
    <name>L7JZE2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_0887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZE2"/>
    <dbReference type="STRING" id="72359.L7JZE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0887"/>
    <dbReference type="HOGENOM" id="CLU_953724_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZE2"/>
    <dbReference type="OMA" id="DEWIRPC"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ76127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="292" mass="33668" checksum="F0F04AD23EAA8432" modified="2013-03-06" version="1">MESKTCWICLRTDNTEDKDEEDGVSEQAPSDEWIRPCHCKGSIKWVHSRCFYKYIMNQTKSKLRCIFCQTKYNIIIRDYLFIHIFEFLNSFFMNVILAFSFLFLVVSLYLILFVYGLSVMLAATGLETTQSLFYRTEDDMLLFDYIGIARALLGIPLLPLSILYSNFKTYSFLSHIIPVIIIIDIPRLSISNVLFSSLPILYFLYRVVINYIKEKVSDTSDGSRHDDDSRTEIIFNDFNIPVKDVGIALLTPYIAAVMGFAVRRKASYSGTLLGGAMVTFTIDFSNIMYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZH4</accession>
    <name>L7JZH4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0421"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZH4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="954" mass="110580" checksum="9D26C50617E774A7" modified="2013-03-06" version="1">MLYNIADYLTATVIYIFVFSSVSKDDSEYMVFDNLKHTNMSKFLTSLEKDPTLNEHFNIKQFDVNQVIDKGVTPSVGTSQDDTNSETGERKPKRAKIEQQPAYYNCIRSYYKPTRLFKIVTVPFSKKLYQKVLGLKVDLKFETNDYIDIFKYIFLNLDDNGDFLDNAWQSICDYPTEFLNVFKKNAENKSQPSSVHKDVSSFLALNFERGMEAFQKAMNSQVVYKLMNDEKTKVALVCGKYRHNNRIIIDKSLDGFEFGFLFECLEVTYVDLKKNFKLYSEAFAFRKQLLNTKLTITIKETRPLDELKPVIHGKYTLDSDFMKLLRCQFFEEEHIENIVIELQSKEIVDNPTICNAEDLYDCIKTLKFYVNYKNNKLQPIHSIEICFSGNINTIQQITKVENLTHVELEDIIFSSDFVINKAWKSLELRDIVALKGTITEIGCECEKLVLERLEGRFNLSGTAGFNEVVMSESSEFVFNKKTKSIDSFVYLIDLQINEFTAVENGIERIWINQTKCTDIITLKVTPEHKNIKIHNTEGKFYFDGIFCALLDFGDKTSLTIDKGDKSQMSVVLKYFVIDNVISFPGCYDTVELVDIEILRGKFLIVNGSCRTLKIICCKGRITKPKSVQLDKLIIEFNPKSRNELEVEGMSNINELVLENIPCDENIIANILNKLENVKFLRITFSDDQNTRARNFEGYLKELYGKNNSLNGSNNDLQDARPETVLFEDSFEKISTCQPIKNFLDVLHQSKIILQLYGLTYEKIFMSGYEMIQYSKYAQNLKALDISIEYLTDQSFKYIFCGIEFLNLDYSCIPDEKLHEKFKTLKKFDKLKVLVVNGIFFTNKANFSFIPATTKVLIIEYPDWEETSHTEKKVEKTKLNKLYLLMKVGKVSDDNKKVTNTKIIKDLKILSQYIDMKNLEDLIIIKGEIHYEIEPTEFNLLRQYKQTLCLGLGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZZ4</accession>
    <name>L7JZZ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0332"/>
    <dbReference type="HOGENOM" id="CLU_1273053_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZZ4"/>
    <dbReference type="OMA" id="RINYMPY"/>
    <dbReference type="OrthoDB" id="10467228at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="217" mass="26393" checksum="0BB79BA4C31D63F1" modified="2013-03-06" version="1">MVLCIFYFICGAMNHRLNYMPHTYTSDDNGDNNGIYSYSYHDRRNPEDNSLYKYKNKTDDMMNFDQRLYHNIEQVLRKRSLYNTYHNNGIIDYNNSVKEKVNRGNATPGEYDNFKQMEKEEIRTMNENQPIAGETNNVNKEKKKFNVLKWLENYDDEMEEDSEAELQKILEDERKKQEEEAKEQKKKLETKERENAKEKENRRIRFLQWVKRKLKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7K059</accession>
    <name>L7K059_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein DRE2, required for cell viability</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0566</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anamorsin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K059"/>
    <dbReference type="STRING" id="72359.L7K059"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0566"/>
    <dbReference type="HOGENOM" id="CLU_121509_2_0_1"/>
    <dbReference type="InParanoid" id="L7K059"/>
    <dbReference type="OMA" id="TMPPGGC"/>
    <dbReference type="OrthoDB" id="2189090at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="13344" checksum="7A031CFC46BC48DC" modified="2013-03-06" version="1">MATENDDFKKLLEGALKVKNRRTEEDEKDFLDEDASESVSNSRRVQKKKRACENCVCGRAEGKKKLSREELKKMSREEVKKLANAGCGGCKMGDAFRCGDCPFYGLPSFEEGDEVFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K063</accession>
    <name>L7K063_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993827">
        <property type="protein sequence ID" value="ELQ76721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K063"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0285"/>
    <dbReference type="HOGENOM" id="CLU_3224893_0_0_1"/>
    <dbReference type="InParanoid" id="L7K063"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="5193" checksum="21BA6F516DA4E0B7" modified="2013-03-06" version="1">MNFRAVDGDKITNIKNISLEIDSNVVHIRVVAFFDFKKKVFYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0B3</accession>
    <name>L7K0B3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0B3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0148"/>
    <dbReference type="HOGENOM" id="CLU_1932685_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0B3"/>
    <dbReference type="OrthoDB" id="10637731at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="131" mass="15589" checksum="1A0EBD3EBB3ABD6C" modified="2013-03-06" version="1" fragment="single">VDAKREKTKQLGYYTWSRKRPKQDRTIYEDENEPGRRKRKSVKTSDNVVLMRIFHKKLVEMINCAKLMIGKANKKLLMMLFSIQLLVDYYKVGNLNMIVHHGRCKLELKRSQRCYEIENSKSNGKYKCICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0C4</accession>
    <name>L7K0C4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin activating enzyme UBA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0C4"/>
    <dbReference type="FunCoup" id="L7K0C4">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0C4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0312"/>
    <dbReference type="HOGENOM" id="CLU_002556_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0C4"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="8">
        <location>
            <begin position="866"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="982" mass="113269" checksum="36C9AFC5A89EA675" modified="2013-03-06" version="1">MQTATTGSSINESLYSRQLLVLGPKAHVKMMQSKVLIIGMSGLGQEIAKNLILAGVRTDIYDDSLVRKSDLNTGFYFQSRNVGQRKDESVLNALRELNTYVHVGIGDIMENREMKEEVLKSYTLLVLVNADLFEQERVNEATRRCNIGFIGCLQRGLLGCVFNDFIHFTTRDVNGESPKLGIIANISCESRDDEYTEDHIEHHRRDKKKRTGEHNVYTLRTVDRHNFEDRDRVKIGDAIFSVTVFNPYELKICTKTVVEGDTYEEIKKTKIFEFRSFAECKKEENDEVFRLLHTHALFRKEHSRDPSPRNESDRNKFLEIYEKNYSEAKNELPGDFAETCAASFMPIVSVLGGYVAQEALKLCSERFTPLLQFYYFNSYDLLLPHLFDESSEKQKEEDKTEKKEKRDTCADNEDYKCGDDKFSDLIVLFGRKKLDQIVNSKIFLVGAGAIGCEHLKNLVSDVTVTDMDTIEESNLNRQFLFRKKNISDFKSVVAANVICQMREETRADKIVPYTLAVNSSTENVFSDSFLGKYDLFALALDNAEARQYMDGRAVVLKKPLFDSGTLGTKGNAQCVIPYLTESYSSSRDPPEKEIPLCTVRNFPHLIEHCIEWALTQFQMLFTEVKQTNNTDESRSVNIAGEEDAKSDEVKLGENLFEHISKSPPRSKKECIKYAIDLFVSFFKTNIQKLKELFPEDHITEEGLRFWEPPKRVPREIELSEESDLHLLFLLSCSNLLSTCYLDGRKITKDDFCEDIDEEPCDSVQKKKIIFEKDDDTNWHVDFIYAAANLRAQNYKIKNAERLDVKRIAGKIIPAIATTTAVVSGLICIEMYRYLLNKDKLSNQQEDGVKEGELKFVQIRHKSEIIFMNSFINLALPFIAHSETLPPIEFECKLFNRKFNLWDQLEVKDCTIEQFMKLFGDLKVEMISHNNKLLYCSFYDTEKNDRYYYKNIMSTVDENCDFVMVDVLFDAECDNCMNIIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0D5</accession>
    <name>L7K0D5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0D5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0338"/>
    <dbReference type="HOGENOM" id="CLU_3417319_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0D5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="26" mass="2933" checksum="FC27D7B7EB37D48D" modified="2013-03-06" version="1">MVGPSGSEECVELVRCIVMIVQHIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0D7</accession>
    <name>L7K0D7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="5">1.3.98.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.3.98.1" evidence="5"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0D7"/>
    <dbReference type="STRING" id="72359.L7K0D7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0343"/>
    <dbReference type="HOGENOM" id="CLU_013299_2_1_1"/>
    <dbReference type="InParanoid" id="L7K0D7"/>
    <dbReference type="OMA" id="NNMIGAC"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907:SF1">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="352" mass="39419" checksum="D7C787004CAD5F5A" modified="2013-03-06" version="1">MILSLAPMLKVTTPQFRSLIRIISSDVHLFTEMLSAEYILNNDNYQTRIGAYDPLTIIQLGGSDPVKISLAVLKIISQTEFRRFNLNVGCPSPKVTKGQFGASLMLKAQLVIDIINEVYNVTNVTLSIKCRIGVDENDSFAFFHGFVEQVASNTKCRDFYIHARKCWLKGLSPKENRNVPMLNYEFVYALKRKMPFLNIHLNGGVKCLADGDGLDGIMLGRTVMKNVFAFEDIKARNKAAYENNDSHGDSLRSDSSTNQQAVQQSDLLSLSNEHKGLQKQIDYYYIIKTYLGTLNQDKSLKPCDIVPLINIFRGKKGTKSFKVLLATLAAKKIAVSACQDEILQCVRNVSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0I2</accession>
    <name>L7K0I2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0I2"/>
    <dbReference type="STRING" id="72359.L7K0I2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0216"/>
    <dbReference type="HOGENOM" id="CLU_419892_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0I2"/>
    <dbReference type="OMA" id="CLERSFR"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="653" mass="72911" checksum="50828C3897827948" modified="2013-03-06" version="1">MSIPSSLREYFLGPTLTFHHQKTIMSTLYSQLNNPRFFRLVVVVTLISFIALIVRVVRLKRQTGLLPFVMGGILIYSGFCLERSFRVGMLMEVGGSKWRDVIGVGGIRNSYVREKILYLFRRPKEDNVGKETVNDEKESAGREKVIEPGSINEEKIVETESMSKEKMIEDKKEENKIDEKTKGSKNGKNVTDEKVVTDEINGDKEDVKTNLKVKNDPLKGTNENETNDKARKDKMSDEIERSDKKGKDNHESTDAQNMKENTGTDSGTMNEEKLTIVNKTNGKGADIINERQNVQKSGVLRNKASENFPKISNSPPGGAPMSSSQPGNATSPAETVDSDLKNGDAPQETAETQSNKKTVYNDTLEQQEFLTSLKQTMLHKENALNRIKVLLSSLKKTRKYVTEDLKLFEDNFENFLKASAEVSDVLSNADISPELYKIDMHELKKDVWERIGVVDVLEGFLRITKGPRIIPKGDLTGSTKFYFENGDHLKEIYGLNDKSSVFNASLKENVNLVPSTISNTVISTNTDNKDNINLLPSLGLENNAVNTIDTGLKDRVMNLLPSLGLRSNALVKTFGANLKQNMVNLLPGRATNNPKLNNKPFSALLNTGIRRSAMYEPPETADLSATSLSNNKFETQKTKIGSRHSTCKKRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0I3</accession>
    <name>L7K0I3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histone deacetylase</fullName>
            <ecNumber evidence="15">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">THOM_0221</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="15"/>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0I3"/>
    <dbReference type="FunCoup" id="L7K0I3">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K0I3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0221"/>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="InParanoid" id="L7K0I3"/>
    <dbReference type="OMA" id="RCHTDEY"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070211">
        <property type="term" value="C:Snt2C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045128">
        <property type="term" value="P:negative regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034503">
        <property type="term" value="P:protein localization to nucleolar rDNA repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF14">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="11 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="19">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ELQ76782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="416" mass="47533" checksum="0B81D087242A1F2B" modified="2013-03-06" version="1">MKNRIAYFYDSNIGNYHYSEGHPMKPHRVRMTHSLLVNYSLYKHMDVFKPTMASFENLTNFHSIDYINFLQSVSQSNMDDMIKDLQKFNVGDDCPIFRGLYDYCRSTAGSSLCATYKLNTREADIAINWSGGLHHAKRGEASGFCYVNDIVLGILELLKYNERVMYIDIDCHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGALKDTGLLRGRNYAVNVPLKDGIDDFSYQSIFRPIVSRAVEMFRPCAIVLQCGADSLAGDRLGCFNLTNKGHAECVRYVKNLQIPLLVLGGGGYTIKNVSRTWTYETAIICDVQIPEELPYNEYMEHFGPEYKIHVLPSNMENHNTADYLQSIVHTVYENLRGVTPRPSVQMMDIPESFVTMEDEDVIWSKFKDEYFIKSEESANDEEVAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0L5</accession>
    <name>L7K0L5_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">RNA-directed DNA polymerase, Retrotransposon</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1421278at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <dbReference type="GO" id="GO:0003964">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="87" mass="10302" checksum="836507CBB23A4571" modified="2013-03-06" version="1">MKRIENWSGKWKMHINVKKYGYIAFNGGNKETPRYRDEEISRVNEYLYLGIPFTRDINLMSVINDRKVKAGRAHLSLKPLLTKPTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQX5</accession>
    <name>L7JQX5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ73873.1"/>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3408156_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQX5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="30" mass="3659" checksum="7A91FB411B41B2A9" modified="2013-03-06" version="1" fragment="single">VHAIDYDYLYTLYDMVHRIRIMNEVVVSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQX7</accession>
    <name>L7JQX7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JQX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3214"/>
    <dbReference type="HOGENOM" id="CLU_251011_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQX7"/>
    <dbReference type="OMA" id="VAVECCV"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="307"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="750"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1026"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ73839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1456" mass="164859" checksum="C3E15F95CED68F29" modified="2013-03-06" version="1">MYHFIVSILMSMITRMKRVIVNKRSLIVVIGCCGMKMNGKKLKNERETLMTGEKERGRREEEDVREGASDRESVSDREGVRESVSDKESVSDRESVREVSIDEEDVLERVNGNYDRNVNHDGNVNYDRSANEEKARTSSKEKNQRSNKNVRERNSTVRERNKNVKGGKEGTRKDSKNGRKRTAIRTTNAELQEEPDKNAEIMNNTIKKIAQDLKLDVSQAKKMLFTLTHSEHPDILLYDMLGPAYVQEIPFLIEQRTLILSAHKKKTQYYTEVVIPPKPIQHDLPTAINPYKMFPYKRFNSIQSELHTIARTNNNFVLAAPTGTGKTDVAMMCIMGATRVVYVVPLRALATEIVGKLRRTFSCEECARLRRRIDRAVECEEKSNFVSLRGGNGRSVDGNFNDEEVNHCKDVEGFDNFKGSNSKRSNSKRSNSKRSDSKIRSNPNVKTNPNVKTNTIPNSIPNYDDNTNPSDLKTTHPKTRPDDNTYSTPFGKPPHNNRYGTKCMDVMEYTGDTPNQSLNTHIVVTTPEKLDASTRKLSFNFPFDLLIIDEIHLLEEERGSVIEALVARFIGRTRIVGLSATVPNVYNVGEFLRGAVFCYGDERRAVAVECCVVGGKEEIRMSEEELRCRREGYGRDYNGGEGLDGKYGGVDQIREVNVQVKGQANAFSNRMDQINNPSSNKLPNRSSSSRFPNNPSSNKHPNRSYGPSSNHPSNHLSNHPSKHPSNPSSNKHPKSNKRTKIVTVNNFDEILIEKLLLCNNQSLIFVNSRYECFKTATLLVKRLIRNETYTRPASFAYLLNNGVGVHNAGLPRQQRLHVEELFRRKELKYVVCTKTLAWGVNLPAENVFIRGTEYYSDGRHRNVSISDVLQIIGRAGRIDYTAQHTLARAFVITNDLPFYVARLKRQLPLESTLLHSLVNVLNAEIARLAVKDEQECKQWFGRTYMAVRVRRNARYYGMEDEHEVDGLVELAVRKLEECGMVERGEGLGCTWEGRVAAYYYLDFSTLVVFVRFVSAGHDVRVSDRAVSGGAVSDRRVSGRTGGNDRVNDNDRVNDRINDRFEEERQEKVPNDTNNVKNIKNTNAERQEKVLNDTNNHTNNDNVNVPITPHDNSLTQKFAALSTACNANNDLLLFKSKFGSFVARALSALEVQILSTIFGTKEFGDILVRQNEQQFVLTTVGMSAAVEVTPCEKLLFLTAMHLMQMSTAIFSLVSDLAFVLKNVGRVMGALEQLAMLAHSYALCERIMRLRMRIEHRGGNTCAARARIDVLSVNGHECSVLSIDSNADESIFCFVYEGRDENCTYAAVLHGKAVFYFARALVDVRVVVVSERTGRSQTIVPVPGQGPAYIAAFNYRLVIFRLFYKRERMMLMNEEMKRFLKNARGEVLIVEEHSYGDDRTGVRTVVPRALHAVPDLNVYDLIVIKGCFSLEMVNVLNAYGKEVFILENENVCRFLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQY5</accession>
    <name>L7JQY5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3200"/>
    <dbReference type="HOGENOM" id="CLU_3299688_0_0_1"/>
    <dbReference type="InParanoid" id="L7JQY5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="5042" checksum="8E2C10671E0EF6D9" modified="2013-03-06" version="1">MVLRNKRYLELEMMVDSYDVIEFKITILWRFEYYCTSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR13</accession>
    <name>L7JR13_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3191"/>
    <dbReference type="HOGENOM" id="CLU_2456349_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR13"/>
    <dbReference type="OMA" id="VMGQTEY"/>
    <dbReference type="OrthoDB" id="10386827at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="10601" checksum="0E4ECBAA30E96BC3" modified="2013-03-06" version="1">MDPKNMMHLIFDLSDGTSERVMGQTEYDIALKNEKPPRKRERPEDEEFDRMPSGRPFREDTFALEEFIPPGVDRESFKRGFMLCQDMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR28</accession>
    <name>L7JR28_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_3172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR28"/>
    <dbReference type="FunCoup" id="L7JR28">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JR28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3172"/>
    <dbReference type="HOGENOM" id="CLU_009894_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR28"/>
    <dbReference type="OMA" id="ETIPICP"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="153"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="415"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="640"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="415"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="710"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ73894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1089" mass="122508" checksum="7A994F9A2B8D72F3" modified="2013-03-06" version="1">MGLLRNEECVSFERLMELKEEIKRRGIEQFVRIYRCKKDVVARFSCGDEIECMLVGLEGDDYKLCNVAEDMIEYFRNCHKRMLEICKDMDGEEGVVRDEGVVGDEGVVGEGDVRRDLDKVNREEGVKEKVRDEGVVREGDVRRDLDKVNGLEKDDKKDKAKEKDKATEKDGAIEKDDKKDKATEKDKAKEKDNEKYNEKDNHPNTNPNTNTKTSPLEPLNNAEHGLSLRECKEELLYLLKYNPKRIKDLYGYDTLNIGITLIPEYASYMVETIPICPITQPGLFHSDMKQRVSLVEHVLKKFIPCGVPVLMTTYPLMGVGHSFFAKKLKTYDFSARSKVLTYDATRSLSFPDNAVNNHPRFLSFMCNIAKRRGRKVEGYCAVMRDECVRGEEIRVLTEEMRRCIDDDGRAGCNGRDGRVGCDGRDGVGGDGRDGVDGDGRDGVDGDGRDGVDGDGRVDGDGRVGGDGRDGVGGDDKYNDRDNDRDKDRSINPITNNDNPTNDNDTNNTNTNTNTNTNTNTNTNKEEQDKAPFVDTVLIDSMGQGMGCCCLQVTVQPGSMDDARFIHDQLAIISPLLLRLTRATPFAGGRLLNTDTRWDMITYSVDCRTDEERGCEVYVAGLCKCGRCDVFVNNGFNRGGKTGVDGRVGVENDVKDEEGGISGGKTGEGKTEDKNVKDEEGGSSGGKTGEGKTEDKNVEGKERGSSGGKTGEGKTEDKTVEGKTEDKTEDKTEDKTGENNVKDADHSPNIKNNDKNVKEIINGHGLNNGTFTLRQSKKSARIPKSRFSAVDLFLWEGGRKYCDLPVPLHEHSLRTLRAHGIDDMLSTHIASLFIRDPMLAYEHTHAGACDDFENIQSSNWRSVRFKIPLDDGWRVELRTMEIQPSVFENSAIVGFVMLFVQYVLKTRINLYVPMSCVNDNFRRAGLFTHPAGAYKDEQYERMEQLFSCARDALARNVPFSEYRRIFEGYAVKVPKDTTTFAYRTNIFESGDAVIREGTLDEIFNGTHEQKGIVDLLIEEYPSYKAMLTFVKMKASGTLVSVADYFRYFVVNHRAYGNDGRISREVCNDLIRKVDEIRRMDHWMYLKRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR43</accession>
    <name>L7JR43_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994098">
        <property type="protein sequence ID" value="ELQ73909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3187"/>
    <dbReference type="HOGENOM" id="CLU_1161854_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR43"/>
    <dbReference type="OMA" id="RIMFEYR"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="239" mass="28368" checksum="D8225E111EFF6FBA" modified="2013-03-06" version="1">MDHKLFILCYFLFLALFLVICAIVILYTFLNQENKKFIRKVRIMFEYRNRLIFGYKNDKICVLIVMHVSEVDDKVLRIKRIINDSSGGIQQIVEKDELDSRDLSYFMVEINKKQNDELRVWYREINLEKLDSYKTLKRKGFLIGIASKIFNEMDVCRFDELIDYMMKACCCSMDKKCFSTYTLGDSIYVRCFTICSCNNVMDDGSRVFQFKGSRGMATCSYLVEKVFRDRKKLKGEEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR57</accession>
    <name>L7JR57_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994097">
        <property type="protein sequence ID" value="ELQ73924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3164"/>
    <dbReference type="HOGENOM" id="CLU_2644902_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR57"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="77" mass="8909" checksum="74317F5AEA234434" modified="2013-03-06" version="1" fragment="single">VHFFILFFISRDTWPRFDAATGDGLLYRAFVVDGNDEWWEDCHDMVSIWRGVRTALIVLMMGLVMLFTPLLAFVVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRC7</accession>
    <name>L7JRC7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRC7"/>
    <dbReference type="STRING" id="72359.L7JRC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3082"/>
    <dbReference type="HOGENOM" id="CLU_1135839_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRC7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="245" mass="28443" checksum="0A7A8A4BF18FDD4A" modified="2013-03-06" version="1" fragment="single">VSSYAFYSISATISFIPIITGMAFNSEHKMVKREIAVNTYSITSYYFSVLLFEYLRCLPFMIIFMIGSKIIIGQMVDLMIMFIYFLMFTTLIVAYLFYGSVLRGTKKVILVYGLFIIFNNAQFCPIIASMRKDENLSKIFMISYLLNLCPNYVLGVCPHIHAFTKMKDRYAKLVDENGINLYKLLVADTREELMKQFKSLLVGYEIPIVFNYLTCVVLIIVYMLLCILMLSFHLQAGYRIRLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRM8</accession>
    <name>L7JRM8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3141"/>
    <dbReference type="HOGENOM" id="CLU_160884_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRM8"/>
    <dbReference type="OMA" id="PMQDNIR"/>
    <dbReference type="OrthoDB" id="10318475at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="13316" checksum="4432959B7D8E74AF" modified="2013-03-06" version="1">MSERIDLIEAYAKKNREKMRKCRKIERVMIRTRNTAVLLCNKRLEYVIEENVKLQAKNIELKREALEVLTRQYKLKQRIEELEMKKDVYKKKIKQLENMREAQSEQSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRN2</accession>
    <name>L7JRN2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994072">
        <property type="protein sequence ID" value="ELQ74133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2961"/>
    <dbReference type="HOGENOM" id="CLU_497138_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRN2"/>
    <dbReference type="OMA" id="RIRCIFA"/>
    <dbReference type="OrthoDB" id="10455295at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="548" mass="63623" checksum="1CE6FAFA01A0432E" modified="2013-03-06" version="1">MKDCDKMMRHKETKMVNIDTEKIAIKDTKIENKRQEIVEKEQISSDSVVLIENTHLHVESAKTYSYIENGDEHHDHGIAADECVVNDEGCNDSKQMSIKTRTGVDCTIASIHSPNVAFIDDKNSTDQSTPLNSYVTYQSNKKCFKDFIKSFDTLQSILYEKMQTYRELKETEKKTKPYELINFFSNENTLSSLSLVDLKSLYSELSTKLGNAEYEFKQEMIKKRIRCIFAAEFRRAITNMATLLSNNELLSFIHVFNSEEKYFLMVKYLGERKRKCCEMNGVLGKKMFVVEEMVRQEIYMFYVVFRCEYERLKKWTDGYWNDKELNEAENKTKCNQKDVNTFNEGDEKSENEVRIGSNNVIHEDGKIPSTNYKLQKNHSDAEDKAIDVTNYTNCANSDECASRSNNTLPSESEIDLKDTKNQNRSVEMCRTEDNNLTKIKQINFYARIDGKETFLIRPFASFLMQNNVLKLLDAFVFSLTKNVLKDYTHADVQGVVDRNGTIITEAVRAGTINENFTDGVRFYANVILWTCFGEYEEKRMENEGQFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS41</accession>
    <name>L7JS41_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Molecular chaperone (HSP90 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_3241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS41"/>
    <dbReference type="FunCoup" id="L7JS41">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JS41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3241"/>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="InParanoid" id="L7JS41"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000357">
        <property type="entry name" value="Heat shock protein HSP 90-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="161"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ73866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="760" mass="87579" checksum="4AA0DCFB53ACDA5A" modified="2013-03-06" version="1" fragment="single">VFSFTFLEFLNYKSKKIMPFMSVEKTTEQTNTAQNTSKKEINAKETYSYDVEMNNLMSIIINSMYSSKDYFLRELISNCSDACDKLNALRQDLREKGVNVDMQLKMSVTPTEDTITVSDNGIGMTKDDLVKFLGCVANSGTRKFREAVKNAKGPVDDLIGQFGLGFYASFLVADKVQVVTKYPTEDKQYMWTSSGLGHYTVEEVPVDMEHGTRVVLHIKESCREFVKKEKIKELIKKYSMFIGYPIVLRTLEEKEVDDDEDKVEVDPETGEKVKVNEDEEKVKVDVDEEKEKVDEEKTTTEEKQQDEKVEVDPETGEKINVNEKVTDEEEKIDIEKNTERTEKPAKAKKLVKEWKDELINKEKPLWSMNPKDVTKEMYTSFYKTISNDWDDYLAVKHSHLEGSVSFDVLLFALKRPRFNMFSEKGSKKHLIRLYCNSVLVTEDLELPDWLSCVVGVISSKDLPMNVSREFLQGENVKRLIKKTLRKKTIEMLKEMNKETYDQFYKEFSGAIKLAVRDDNEQQLESLLRFNTSKRENIGLDDYVKDMKEGQNKIYVITGTTKEEVVKSPFLEYFKDYEVIFMIDSMDEYLLQRFRAYKGNDVVKINQEGVDIPNAEVSKEMQDELKALKENIEKTLGDSVERVEFLNLGDKHMLVRSPKYSISPAMEKILAAQVAIDKSNMFMFPKGKKILQVNVTHPLTLKLNSVMSDATVFAKLLNLLFKVACLQCGYALDDPVGFADMVSDVLMSDRVEKVVEEEEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS58</accession>
    <name>L7JS58_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2751"/>
    <dbReference type="HOGENOM" id="CLU_2943463_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS58"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="6673" checksum="2E397FDD62ACAFDB" modified="2013-03-06" version="1">MTEQTRHPTAKRYKEETKTAISKLIFVCVTILMVGSAIIFVCIAVFLVLKEWNKSDVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSE8</accession>
    <name>L7JSE8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA ATPase containing von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2641"/>
    <dbReference type="HOGENOM" id="CLU_2185773_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSE8"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="12703" checksum="941131765F237EAE" modified="2013-03-06" version="1">MNPSSYKGRRALPKSFLDRFVCVRFERFDGQEIVDILGESVARLMVRYGCTMRQCVRARIVGENVVVGRDVKYRMDGRRLRIGRTIIEGGSXXXXXXXYYNPSPYYYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSH2</accession>
    <name>L7JSH2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Endonuclease/exonuclease/phosphatase, putative transposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2675"/>
    <dbReference type="HOGENOM" id="CLU_124781_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSH2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="187" mass="21428" checksum="8A62B0D287DD1F8A" modified="2013-03-06" version="1" fragment="single">VEGLAEDNTTFSILMVCVYIPCQGVARRNALDRLCNFLHRERDRGRFSEIVVMGDWNGVPGQSHRHLHARQVATNEEFLGFTRATRFARAPARRGRCIDYFVSLNNAIVEKQRVLRDVDLSDHYPVVASLAVKHITAAPDKLIYDRLKLQLIGKTAVEILSDRRWLTCRSDDVSERAKQLRLLVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSI0</accession>
    <name>L7JSI0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60s ribosomal protein L18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSI0"/>
    <dbReference type="FunCoup" id="L7JSI0">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2822"/>
    <dbReference type="HOGENOM" id="CLU_080024_2_0_1"/>
    <dbReference type="InParanoid" id="L7JSI0"/>
    <dbReference type="OMA" id="KIVALKW"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="128" mass="14421" checksum="1EA0DC599137120E" modified="2013-03-06" version="1">MSRSNRQPIKVAKLAEHAGKVIVVVGKVLDSERVFTLPKLTIVALSASREARRKVKKFGGEIYTLDKLFKVTSDLKNVVLVCGDRTKRKAYKYFGAAGEKNSQTYPRTTNKRNSGEKRINQPKKKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSK1</accession>
    <name>L7JSK1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonucleotide reductase, beta subunit</fullName>
            <ecNumber evidence="2">1.17.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2"/>
    <dbReference type="EMBL" id="JH994039">
        <property type="protein sequence ID" value="ELQ74463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSK1"/>
    <dbReference type="FunCoup" id="L7JSK1">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2610"/>
    <dbReference type="HOGENOM" id="CLU_035339_2_2_1"/>
    <dbReference type="InParanoid" id="L7JSK1"/>
    <dbReference type="OMA" id="SNPFPWM"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="325" mass="37871" checksum="4F4ACA8FCE6D5EF0" modified="2013-03-06" version="1">MSHPPEEALLTEPTNKYTLFPLTNQDVWQMYKQALSSFWTVEEVDLSKDIDDWNRLNCDERHFISYVLAFFAASDGIVNENLLENFSREVQLKEARCFYGFQIMIENVHSEMYSLLIDTYIKDQEEKDFLFNAIANINTVKRKAEWCFKWINDKDSDFATRVIAFACVEGLFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHYQFAVLMNNTLVNRCPKEKILEIVKDAVEIEEEFVSDSLPVSLIGMNCKLMCQYIEFVADGILVDLGVGRRYNVQNPFDFMENISLFGKTNFFEKRVAEYQKGYVGIENEQTFKTDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSL9</accession>
    <name>L7JSL9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994082">
        <property type="protein sequence ID" value="ELQ74046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3049"/>
    <dbReference type="HOGENOM" id="CLU_3162573_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSL9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="5763" checksum="8843B36E572363CC" modified="2013-03-06" version="1" fragment="single">VKDRIHEIDKINSKTETVDEPMQDYTGFEEEISGEIEEHYDYLQTEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT24</accession>
    <name>L7JT24_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCAAT-binding factor, subunit C (HAP5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT24"/>
    <dbReference type="STRING" id="72359.L7JT24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2543"/>
    <dbReference type="HOGENOM" id="CLU_1511039_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT24"/>
    <dbReference type="OMA" id="MRAWCIA"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000062">
        <property type="entry name" value="Nuclear transcription factor Y subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="182" mass="21246" checksum="81E8C6119986B62D" modified="2013-03-06" version="1">MDSGGRTLKNKTKAIIENFWLRSLHKADTESWNYKDLQLPLARIKRLMKVEEEVKMVASEVPILFSKVAEMFIEELTLRAWINTEENKRRILQKNDLSAAVRTSDVYDFLIFIIPRNELDPAYTAYEDNQGMEDNIKPFYNDGQFYGKHPDNLVSKQTMNHDYANYSVNAPTAESNLPQHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT27</accession>
    <name>L7JT27_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2565"/>
    <dbReference type="HOGENOM" id="CLU_1078433_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT27"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="258" mass="29933" checksum="558E2211A3439DED" modified="2013-03-06" version="1">MNATNILIYFTLIFKKENENDQNNQETYESVVEAGLSNYVNSPAKNQVVLKELRTHSQNINGCLKPYYEDEQCNLSSAGITNIDLYDAKIPEEGKLLGYYVPLSKILYQKILHLDITSFSCFDIKEIYEIITSEIYIIMDNSMLLINCILHVLNTAKEKKELLYEHHWQSIRNQLVAINGFEKIEMQLTRSGKLEDREKVMADIVNDLLALNDDPMVCHSIQNIYDRFNLWNNKFLTFLKAVKKKFLSKSATRSTNMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT60</accession>
    <name>L7JT60_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2528"/>
    <dbReference type="HOGENOM" id="CLU_1571800_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT60"/>
    <dbReference type="OMA" id="IKMIEDY"/>
    <dbReference type="OrthoDB" id="2194038at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="170" mass="19965" checksum="9C21C139069FD490" modified="2013-03-06" version="1">MVNTVLDKVIRIRKLIRTNKDAKIKMIEDYVYFKGVMFRMEKEIDEILIKKKEDLQLEELRKKKRRSNNDKALVRRCTKIEALEDINEIRGLENESVVTVTDGVLRVKRSEFRKKDAVKVNMHGEKFNAVLLSISPSGIVVKAKNGKKYKIMIQSIKKDDVRFIKLERSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT97</accession>
    <name>L7JT97_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2 14">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">THOM_3122</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2 14"/>
    <dbReference type="EMBL" id="JH994095">
        <property type="protein sequence ID" value="ELQ73982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT97"/>
    <dbReference type="FunCoup" id="L7JT97">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3122"/>
    <dbReference type="HOGENOM" id="CLU_020346_1_2_1"/>
    <dbReference type="InParanoid" id="L7JT97"/>
    <dbReference type="OMA" id="HYCFESM"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 14 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="18">
        <location>
            <begin position="117"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ELQ73982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="390" mass="45695" checksum="741CBEBA2618DF21" modified="2013-03-06" version="1">MTEDQKTENSRKVEDEIETELEGKRNITSNRGNKNNNESLRTGCKSYKDKEKEIRTNDHGPDVKNDMTAQSGKFQAETINKGFNRNKTTVVVDSYANEIAEHYNKIPSKSYAERRKSYIINIRNMNNFIKSVLFNRYVKRNGRVLDLGCGKGGDLLKYKKMGISYYYGLDIADKSISECKYRYSRHKCPFKADFNVCDTYHTILNLGKRFDVISIQFSFHYSFESEESFTITKQNINEHLHENGYLLLTVPDRNVILRRYHRSRTEKDAEKSISGDQHTTSDVCFGNEYYTIKFKDSPSDRIFGNKYYFNLREAVNECVEFLVDVNFLEQEMKKIGLLVVENANFITFYNVHSNEFAELRRKMLPMRLCTDEVKVTELYRIMVFKKTKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTS0</accession>
    <name>L7JTS0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994022">
        <property type="protein sequence ID" value="ELQ74814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2252"/>
    <dbReference type="HOGENOM" id="CLU_1074372_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTS0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="259" mass="30280" checksum="61D005A10EB99695" modified="2013-03-06" version="1">MLEHNGKQNARTREIVKKIVNHMTHSFLLFLCLDDSIHIISEIYDDIFVELKIDRECDISRIHNILAKYTRHRRGFRYLCQTLELLDMLINMASNKLLNRLLILLNALSEQYNTESEKIRQSVNSTVEHMLHIYHEICHALNDNFDEVLEKSRDFSILLTSNKAKKSLKKIFQCLMLCKVPKFVKIESSPEAKYDDNLQETLELLKSNLFSVQLTSNSVRDCLLIRSAFQLIFKMLFICEAYLESFDVLNSGNGMRVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTX0</accession>
    <name>L7JTX0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2596"/>
    <dbReference type="HOGENOM" id="CLU_2020865_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTX0"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="123" mass="13682" checksum="B982BB4D1010E4D4" modified="2013-03-06" version="1" fragment="single">VHVGAEFNLRDTLGSIFMLRYDLQQGVISFLMRYDVLNLTFYRRLTEFVSVAGEMVAGNSSIGARLGVLLSTHFTDIRVEVNSMMNVILMVEKKLLDCFVFSCCAEVKGAYAVECGLGLSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU01</accession>
    <name>L7JU01_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative POPLD, Ribonuclease P/MRP, subunit POP1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU01"/>
    <dbReference type="STRING" id="72359.L7JU01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2858"/>
    <dbReference type="HOGENOM" id="CLU_036209_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU01"/>
    <dbReference type="OMA" id="FIFPYKF"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="5">
        <location>
            <begin position="259"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="439" mass="52036" checksum="6329A8FC81DF58F4" modified="2013-03-06" version="1">MTFIDAHEFVNERSNEIQELEKSLPPRKKKNMLFQKLPFYLRRRSSSHHRKRKRNKKGNYYGKRFSMICVNGHKIAYQRFEKTSSLLHKGGNFIYSMVYCHGYVYRIDCDIEQQLKNYGYHDVSTSINTEKQDIYQNYSQKNTYTSNIDANFRLYLRNGSKFQMLKTKKFLILLTLDTIPEFLKTKQIYCEAENIFEILKEKELSSSGIYELINGTMTRSDVTIDDYFSNMKDNCVLKLNADFSLLLIFRNLKTIFGSIIRIWRVIGLEEYLRLSLNYGFLVFPFDDVNSDWYKQYEREVFYTENQKYFRTPKGKRYDYSALEENIGNRSRPSNTNQIMSIGSSAQHEDFIFPYKFPSVPSLQFTYLFECKKGNLQRCARIYCSNNENIICGYVLRGSFSYFAGTYRGVMVLSTEWDNSKIYVGINIRSSQKYILTKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU04</accession>
    <name>L7JU04_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DsRNA-specific nuclease Dicer, ribonuclease</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="72359.L7JU04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2863"/>
    <dbReference type="HOGENOM" id="CLU_007990_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU04"/>
    <dbReference type="OMA" id="KAMIHPS"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ribonuclease III activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="RNase III" evidence="5">
        <location>
            <begin position="516"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="5">
        <location>
            <begin position="753"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="912" mass="106699" checksum="2302397DABE650ED" modified="2013-03-06" version="1">MKVDIKAKKYVFIADDNSCFAEIVETCKNIRADDGVHRLFRYLKKSEEKITTKKGAYLEKSVAHMFLSRLLCNLKYLFEQHFLFIANLEYTDVHYSTSKGFVCHLKLPYVSNEPVFTESHISQVERSKRAALQDAAFKSIKGLMACGCLDENLSLIKEYFIINKVYKSWLESTYKIENSYLDQFDMEYQKNINSIDTYPLEYFFSVLNQKETNEQPVFITHVYSLIFKLMQHVVNGCDSTYVKNVFKQKYMVTLKKANLPKIKSRAIPKCFLNLNMNHLYAFSSDMGIICGKTFRETIKLENTSFVYLGEVDLDDQQMSLIALYNVLFFGLHYKKIGYNSTYNYFAVPLQDKKLFLNGFLGNLYENQEYVGYLLFNPFNKNFYVFKDWSDQSINDNAVQIENGPNINDDLLRGEDDNDNGEFISYLKYFEQKYGTHLKYTDDNDKRLMFNGYIYSHRGKGTATTSLLSSEIMRVTPCTKDVFEKYTAFTQNFIYFEVLALVDEAKNDLNLPISLKLLSNCFISKNDKYPDYERLEFLGDCILKYLVTKFFMLCFEYDTGLIVDSKCRIIENSNLTLIGRKLKLESYFSNLVFQPPSLSENICKQLQQYFNFKNTAFNSQTTICSQISSEKTYADIVEAIIGACYVENGLNSTEKMIFRLGIIDMSKYSDSIIGVFEEADSVKNEWKKQKINTDKFLRDIFELDGDASMDTFAKTKTFDFSCYLENCNNGTFFRCNRFLANLAEYHNVMSEEHIMEVEKILNYKFRNKGFIEKAMIHPSTRDKMFGTRSYFEKLELIGDSILDVFVTKSIFNEYSCPFALHEARKNLVNNQIYGNVLYTSKLFHYIETCFDKDELRDSYLVNNYKKLYGDIFEAINGAILLDLDCRADLYEKIWESRIKEWLWSCHKIRKTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU32</accession>
    <name>L7JU32_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2287"/>
    <dbReference type="HOGENOM" id="CLU_1763300_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU32"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="148" mass="16291" checksum="E79AF3933AB3B911" modified="2013-03-06" version="1" fragment="single">VLNKNFTRPLYEMVNHLGGALPRVTFALFVFVYFLRLKLCGFTLMNGRRSAVSFSDLFIFDISQFFFSKSLGLGPPSMGIAEVMFTHHVSIATKISCPDDAGYVRQIVFSSTICFLGEGGRVAYIASLIPASICLNLKSGGGFQICHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU49</accession>
    <name>L7JU49_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding ADP-ribosylation factor-like protein ARL2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU49"/>
    <dbReference type="FunCoup" id="L7JU49">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2229"/>
    <dbReference type="HOGENOM" id="CLU_040729_12_4_1"/>
    <dbReference type="InParanoid" id="L7JU49"/>
    <dbReference type="OMA" id="EGMEWVC"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="177" mass="20123" checksum="87B1302924756F19" modified="2013-03-06" version="1">MSFNLLVKQIKKKSNDLKFIVVGLDNSGKTTIINNILRIDAISSPTFGYTIYKNLYKNTNLTLFDIGGQEALRKYWSNFYEDADGVIFVFDLFDTRDFVGEFNRVRETLADYPVLIYGNKIDLDRERGQSILEKVKNGIDDESVNCYGVSGKMGTGLEEGMDWLIDVAKLNLAKHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU71</accession>
    <name>L7JU71_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2103"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU71"/>
    <dbReference type="OMA" id="CNENNND"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="942" mass="109383" checksum="DDA4154AF3D0413B" modified="2013-03-06" version="1">MWCNIHDYVETTLKYLLIFESKDEMHNDDYLIFENIQDSGMPGLLNCVEATIPTFSSPHQHCNAYFSDDSREDERVFWTNIHYYYDSLSLNKIYHVPYHDLIQENENIRFKIIRVPMSIGLYQKIRKLILKNVCDFDLENLCVMLNNIFLFDEHGKGSIAYAVCTFLQNNPYLLEEVRKCNENNNDGQLTSSVKLLAEFLFGEVYEAIQFRKYVKLYLTVKLTDSNENHGELSSKSLLYSYYTQIVDPNDLLLEFLFDELRISYEWLNNNRYVLDTKFENIKNKSQYTVIIYKSTSLCNHKNEYRILMQTLNQIKSCKFLMGTNVGELVLKFSNVNILPDLSFLNQISALVMIKCYFCSINFIKKIPIKIKVMMCVSEELSEDFIREIPENVFQVKFVRSNFREYVILPNHIQSITIYDNYIDKNAALILSRESNDITITRTPVKIHPLCIMTKGTVCLITAFDSKFLMKKDQVSGLRSLTLSSSKIDGKMNISGIEVVIFELVELSSRSSVSLCESNKYISISKSSGLFDLKLHIGVDLYFEDNMTLTAWPTVNSTHNTSKIKLANCLFQKTVKFADKYKQIELNCVSTSKNVEIILNTACEKLIVYKCAAIINVKNVKNFDKLTLQFSLSEKNHVKFIGLKSVNHLRLINISREVTSIISLLTAVENVKHLEFRSTYKDEKREDINEYMNVFTRTLSAEEDFERFPDLKSKCLSVKDTKPSIFIYEISDIMVNYILKLLLGKGTFNSVIKLVFISISIDIINCKSFVKMVNLEILQMCARNTTNEFLYNLPAKLKLLNICNSFASKRSWKPKYVIKPSIIVHPHNNLKVLVISSHFLSNITSAFILLPKLEVLRIRYSILLRANPREKTNRLKIRKLIIKCGAYMIRHCEESINKGEMASFINDLKTYVDFDFLKYWIITGPNQSIMVNPKTQEVLKREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU86</accession>
    <name>L7JU86_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2023</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU86"/>
    <dbReference type="FunCoup" id="L7JU86">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2023"/>
    <dbReference type="HOGENOM" id="CLU_105983_2_1_1"/>
    <dbReference type="InParanoid" id="L7JU86"/>
    <dbReference type="OMA" id="CLDANKK"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ75043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="80" mass="9242" checksum="01612198439DB0CE" modified="2013-03-06" version="1">MGRKKTRRSQVKSVKAKFRMETRFNCPRCNNEQAVRCTVERSAGIGIAYCTLCEAKYKCRSNNLTTPIDVYSSWIDDIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU91</accession>
    <name>L7JU91_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993999">
        <property type="protein sequence ID" value="ELQ74989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU91"/>
    <dbReference type="STRING" id="72359.L7JU91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2073"/>
    <dbReference type="HOGENOM" id="CLU_1195598_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU91"/>
    <dbReference type="OMA" id="ESPPIIC"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="232" mass="26836" checksum="6BEED457CEAC87C0" modified="2013-03-06" version="1">MVRKQMSSQVLNDDSSDTSEKDIVSMSQQTQDDDSSMESIVEVVLSLEESDCREAERQARERVREKAEKEAEARRKRIERDIQMGRIPPEKDLRPCRLVANENRPHESPPIICADVQRNSIWEAVYVPVDRENNNDDDDDSDDTRKKSPDILQKKQKKVGNTVLDKISVVPQIVPEENAICSICFEKIKGMMYNLKCKHTFHMDCIFRWVYTCNLCPLCKCPILLGIYNGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU92</accession>
    <name>L7JU92_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2755"/>
    <dbReference type="HOGENOM" id="CLU_2962546_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU92"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978871" description="Transposable element encoded protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6834" checksum="E39FC18843F7F4E4" modified="2013-03-06" version="1">MHKRSAIILSIILSIVCMHSHAQECLDLMNEIIDCYNESEGVNESRQVYSKRIRVTELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUD9</accession>
    <name>L7JUD9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element encoded protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2730"/>
    <dbReference type="HOGENOM" id="CLU_2795745_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUD9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979155" description="Transposable element encoded protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7212" checksum="B6A4AD9372E65B72" modified="2013-03-06" version="1">MKVLSIATIIIKIAFVHCRFSNPGSELSDLRRSGLVHGLQGLTSDQPLSPSMIMAKAAAVNAGMFGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUG4</accession>
    <name>L7JUG4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1993"/>
    <dbReference type="HOGENOM" id="CLU_984144_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUG4"/>
    <dbReference type="OMA" id="VETNEYP"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978822" evidence="2">
        <location>
            <begin position="22"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="283" mass="33217" checksum="7B6DC4281E690277" modified="2013-03-06" version="1">MMALYFLNELFISLFITFCSASSAGESDQVVPILNDFHVVKIQLETLIEQMNSIIEQTGQETEINNFTLLKHHVRQLFVNVLIEIENDTENDEQKLIFKYYKQLLDILGNDLFIHLTMIIYKPANRDMIDEVLRHNIEVKKSNELFIELINTKIKNCKNNRAKKQNLSKNITQILFEEIEFVGEIFNDISKGNISKYTSNYIDRTKLWLQNWEKRIVQTDICYQTVETNEYPCSSRHYRRPLSVCLTNEPESCDYLSDSDNDSSEKDQIVPSKRTKKSLTHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUP9</accession>
    <name>L7JUP9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol synthase</fullName>
            <ecNumber evidence="10">2.7.8.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_2592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="10"/>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUP9"/>
    <dbReference type="FunCoup" id="L7JUP9">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2592"/>
    <dbReference type="HOGENOM" id="CLU_067602_2_0_1"/>
    <dbReference type="InParanoid" id="L7JUP9"/>
    <dbReference type="OMA" id="GACLDMY"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ74497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="186" mass="21150" checksum="73A8B0D33EDAE98B" modified="2013-03-06" version="1">MNKDVLFNIPNRVSYARIILLLTSIFLDDDLFVLTFSVSTSLDLIDGTIARYYRQTTRMGACLDMYTDLSTTTVIVCKILERTPSSGLILALFVDLISHTMFFSVAVAQNVSHKKPKLKLLKIYYNTAVLVTLCAGTGIYHILLYLETYKKVNEDVVRVFFVLFILRSLFNVLRFAEGLARLSDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUQ1</accession>
    <name>L7JUQ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2025"/>
    <dbReference type="HOGENOM" id="CLU_1483009_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUQ1"/>
    <dbReference type="OMA" id="DITCKTR"/>
    <dbReference type="OrthoDB" id="10627561at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="182" mass="21442" checksum="D8300FC2D0FAE86B" modified="2013-03-06" version="1">MSEDADLEKMLYLNAMKATLKVLNELEAKNFNKKNDVTISDIEKKKKNDITCKTRVFKKRRNKENPSTGNESRTDVVGSKNSSKKKNDDEKPIEKVKRLKKENGVDERAQAPGRKRSTDHPRIERRKNEDMSNIKSMTKRSQMYSKDDNSKRSSFRKKTVEIDRKSKSSRIDRRKMDKKMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUV8</accession>
    <name>L7JUV8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 1, regulatory subunit</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUV8"/>
    <dbReference type="STRING" id="72359.L7JUV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2465"/>
    <dbReference type="HOGENOM" id="CLU_044236_1_0_1"/>
    <dbReference type="InParanoid" id="L7JUV8"/>
    <dbReference type="OMA" id="MAVNDIC"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="224" mass="25877" checksum="7AAF1CB282BA2C7E" modified="2013-03-06" version="1">MEDEKSILSLPYSNLKQIPTVKEEVQSIILYHNKITSIRMTYLPNVHSLDLSDNLITTIQDLENLPNLRTLDLGYNLLTQIQNLSFLPLTDLFLMCNDIERIENLGIPSLKNLDLACNNITKIENLTCINLEELYLGNNRIRTVENVEHLSKLHTLSLQCNCIQRIDCLKLPKNLKYLLLDGNEKLQELENLECLRKLEYLDVSKTKVKEHDISEREGLDVVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUW9</accession>
    <name>L7JUW9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1817"/>
    <dbReference type="HOGENOM" id="CLU_572648_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUW9"/>
    <dbReference type="OMA" id="NTEEVCI"/>
    <dbReference type="OrthoDB" id="10310821at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="477" mass="56150" checksum="31BA0C6DAD15E7E4" modified="2013-03-06" version="1">MKCDCSWPMWSNLHGYIEMSLKYIFVFINEEKTYGEDFLIFENPEDAGMSGLLNSHEDAETKQTLSHETERRVYSNIKYVNEEISYNRAYYHDHIAGIRRIIYNTYHDVIKENVDTKFEVIHIPFTMSLYRKIMNLAQNGDDVPDLNTEEVCILLTHLSLFDEYAKASIAYAVCMHLLKNTELFNYVKNYTNTNDNRSDSPLKYLSLFLFSKNDVSTQLKKTIKSYINFALWDKYENPSKIYSKSKIYCYHSCNIDPGNFSLAFFFDRLVITYQWLEKNQTILDTKFKESLGDSHYSVYIHNFSLENRDANIVDITMNNLKIVTTSKFLTSENIDELTLEFTNLSNRMDLSCLSKIKASIFVICDFCSLDFIRSIPEYIKVSMRVIDDQPVHILNNIPENVVEITFRSVNFHESIVFPSHIRRITLHWCNVDPYACFTINEECQNIEIFRTQVQIIFPQVIECDLWHPLLMEKIKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUZ4</accession>
    <name>L7JUZ4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUZ4"/>
    <dbReference type="FunCoup" id="L7JUZ4">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1847"/>
    <dbReference type="HOGENOM" id="CLU_052697_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUZ4"/>
    <dbReference type="OMA" id="DRENYTL"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="87"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="282" mass="32479" checksum="D79701FC6226C6C1" modified="2013-03-06" version="1">MTNFMSNMTAGMTISYPIQHSALNNGYIREIGKDFPFKKINIKKEELVENTTKAFQKYNINIHIKVLLNDTTATLASAVRSDDVFYIGIVLGTGTNIAFNDKILYENQIINTEIASFDSEHLRKNIYDMKIKEDILSSNKIYKPLDCMLGGYQLVKLFNLAIKDQFDRENYTLDDIVHLLDLPPGNSNYTEEFYVILSIKKRTMRILASMVFGILEAQEVDSKIKIVLNGTVFEQDYDRRIFIDEIRRLCADSTAYKYKHFTFESICDATLRGIARILLQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV05</accession>
    <name>L7JV05_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993986">
        <property type="protein sequence ID" value="ELQ75140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1925"/>
    <dbReference type="HOGENOM" id="CLU_047045_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV05"/>
    <dbReference type="OMA" id="HMPAINN"/>
    <dbReference type="OrthoDB" id="10438211at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978782" evidence="1">
        <location>
            <begin position="26"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="359" mass="41411" checksum="A4189C1ABCF37397" modified="2013-03-06" version="1">MKTIEMALINTFVVKIILCLTLVNAELVAVNNKISQADLPKSSDDPRLVKLQKEIAWQNKFSRETANELKTFTNLMHRDVLSDIESEKNYISQDLKDKLKNYGKELANILKDKSSSSGTSISIVEKHMPAINNYFDVRIRSKAYFNLKKPEDLENKIQGTVNVQHSHRQDETPEINKSELLQVTDPNLVNPLDKKIKDALGSTMEQLKELNEKILQAEPSITKTADEQNKAEQLSLSLTDVLNKFENECQDYLTNEFRYLKSNLVARHETLNAQIDHVVRNIISKLELVGAKFSSEFTSKGQIRFFLYNTDANSKPVTFEEKKYTPWFNFDSNGNINVYAKKRPFTNLWKGFIRQKKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV72</accession>
    <name>L7JV72_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1680"/>
    <dbReference type="HOGENOM" id="CLU_3210266_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV72"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="45" mass="5259" checksum="3EE8F4A0DCE3896B" modified="2013-03-06" version="1" fragment="single">VFIRRRSEIDKSALSNQALIGNDRHKNILKIFNVIKMEMGGELRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVD2</accession>
    <name>L7JVD2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2053"/>
    <dbReference type="HOGENOM" id="CLU_3191634_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVD2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5555" checksum="4D852508E457E5C5" modified="2013-03-06" version="1">MKIHNNIFDNDFDEFVFLVNLMTRLTVSANETLRFFQFKKQSSCHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVD7</accession>
    <name>L7JVD7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2379"/>
    <dbReference type="HOGENOM" id="CLU_628796_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVD7"/>
    <dbReference type="OMA" id="VKRIRYY"/>
    <dbReference type="OrthoDB" id="10353332at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="436" mass="51521" checksum="A69355C9EA59016F" modified="2013-03-06" version="1">MKKRFIFSVFAQISRIFNILIYLQFMKDSYVVSDLHAIKTCTNQIVRNDRDVFDSIFRDDIVLVIEENFNAQLNQMFGFGGIMGYWRKVKNGTFILSLIYRKFRIGTSNELAGDFRAFKNAEGKKYNLWRFLAAKIPIIEKFYARLCKANAAVSDRITDFCYYPSREIFIEKSNNKFTVRQFTNREELNRYLINNEKMFFYTSLDSPWSAFKCKKKLVYEKAFADHLSFKKLRYIRIIYEIVEAMVYKTQKNFVNRAMFAILASRICDELNESGIKLELKFKKMAVTCFNVTLQTITYDSPSIMMTVLLNYDDQMVLSLFNSLKSNFIKWAKQITYQQVKVTWTTSYIDSVMTIMKIYGVIKEPIDFSVYPEIVGILFPHSFFLNHNPNINSCIIVRSCLCFKNLEKFCGYKKYFDDAVVKRIRYYTDDIMFSLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVJ6</accession>
    <name>L7JVJ6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_2318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVJ6"/>
    <dbReference type="STRING" id="72359.L7JVJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2318"/>
    <dbReference type="HOGENOM" id="CLU_1062455_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVJ6"/>
    <dbReference type="OMA" id="QKPERCH"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="131"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ74757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="281" mass="33042" checksum="4B619EC702F09F21" modified="2013-03-06" version="1">MFLLIGCYRFKFQLLWMKYMLKRNDEFLLLDDKNEMLPRRNIFLTVLLCLTFYYVILYDIYALEKCALIRLSQLALMTINLISLCIILRIDSGQAHSENDSRQSSINFVRDNVIYTRKIPAQRSTTFDSSFYNDDYCEKCLVIQRDFISHCRFCDVCLVNRDHHCAWFNKCIAENNFNVFLCFILSLTFSAFLIVSDTFQIFSAKVLVKLSTFQIIIVVAIMLISMSLFVLSAILSLQYLLSLILGISTKKLLNGEWEWKSIRFFRGIRRTKTLEIIDIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVK8</accession>
    <name>L7JVK8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVK8"/>
    <dbReference type="FunCoup" id="L7JVK8">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1721"/>
    <dbReference type="HOGENOM" id="CLU_076665_4_1_1"/>
    <dbReference type="InParanoid" id="L7JVK8"/>
    <dbReference type="OMA" id="CERAMNV"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="103" mass="12396" checksum="3742A099605EC372" modified="2013-03-06" version="1">MKEKKKVLFTKELKLMMYGFGDTIIPRNDTVDVLHDYLLGYLKNLLIKTQNMARIKGKTKTDDLLYILKKDRRKYMRVKDLLLTNEELKNARKAFDFEDYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVL2</accession>
    <name>L7JVL2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein (RRM superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVL2"/>
    <dbReference type="STRING" id="72359.L7JVL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1726"/>
    <dbReference type="HOGENOM" id="CLU_669075_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVL2"/>
    <dbReference type="OMA" id="VIYCEFA"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="109"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="335"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="413" mass="48125" checksum="EA5ADD5693C8C5BE" modified="2013-03-06" version="1">MRLVVKNLPPKITENDIKAIFREYGTLTDVFLLRRNASLNKGVCFIGYSKEEYAKEAIKQRHGSYIENRKIIVEMVRDDKLKRLKMELKKIGSGSNPEEEDVSVEVKSKSLYLTKLPVIVSKEDIVNYFSDCNIKNIEMVLDEKTGNFYGHAIVTMDDIESAKRAIRQKDVLLGRRIQISFYNEPPSKKEYYSKLFFNFESVVESICSEEKITKKELLDLKDENLGTRISLIETHLVEQTRRFLENNNINLDNLTGKVNKKVLIVRNSNLLSLNFRNCNVKVAPSKCLALLEFRSEEDAKKVYDELQYKRVKDKAIYVDFLPISKIERKELEFTNKLIIKNVPFQANKEEIKRILTTQVKLKDIRLPKKRDGMHKGYCFVTLNSPEDAKIVYQYFGNNTHLYGRRLVIEPAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVM0</accession>
    <name>L7JVM0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2259"/>
    <dbReference type="HOGENOM" id="CLU_790329_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVM0"/>
    <dbReference type="OMA" id="NKVELHN"/>
    <dbReference type="OrthoDB" id="2192627at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="351" mass="41116" checksum="888871D35E3642C0" modified="2013-03-06" version="1">MRKLTEFVKRPKPCDYRNTTKVDTKEQRKLKLKLPLDLSFIIENYHPGLSLSSKLGKKGVFRLASRNFSSVLIKHVEKFLVYDDRREFNVDLAPFLSLKTLKIVDCCFFDFIYLTSAIDRLILDGVRDVKCRDVAVNKVELHNMDVTVVTKLLCTVFIQSLSLVNIDLSRNFEVPKSVKALSIRKCKLTQEKAIEIVQTHELIDFTFVEDDFELECLQNNTVKQPMLRIKHCSKTFYELDYKNIRKLKLYDTKYIELLRIDALESFTLNDSIGDASFLKIFLSRYHLKELNLENSVVPQTMLYDFVVLFKSSLRYFNVQKIEIPFDFLSFLKAHLRKCTVLYGNGRSIRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVM4</accession>
    <name>L7JVM4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993953">
        <property type="protein sequence ID" value="ELQ75479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1571"/>
    <dbReference type="HOGENOM" id="CLU_1086603_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVM4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="256" mass="29019" checksum="251A493FF32D9A84" modified="2013-03-06" version="1">MLTLVDSLFIYNQNAYQYLSYLRLDKVTIKRNVNLTDKLKTLIIESTKICGGFVLRISQTIVNLSLQRFTGAVNIPSIFGSVSIMLYGNEVIELCRDKYSLILKGFTFKRDVELDDSFRIVKLSEVKMRSGGKVILNKERVHLELYLSDVDIDYSKVDELKCITLTKNIRPVAKNILALKTVTTATFKGMKLKNWFICPANIRVISLHCVKMLGNKVFRIGQNCEETNLFNCIGNFDLSSAPCLKKLAIIPFANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVR5</accession>
    <name>L7JVR5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone-lysine N-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.1.1.43" evidence="1"/>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1693"/>
    <dbReference type="HOGENOM" id="CLU_1462334_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVR5"/>
    <dbReference type="OMA" id="CGFNTII"/>
    <dbReference type="OrthoDB" id="2188027at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="21468" checksum="53CA83A85E0DE768" modified="2013-03-06" version="1">MWSISDKAFVYLNGLNIMEYSNLSEYAYKNVIRKEAKARGFHKKQRWNKSLLAGEKCGFNTIICELKGHIMLKDELEQPKDGTVYFDPKLNIAIAFDQQNEINLAKRKCRNNVKIRIARNKEIVFKKSLNGFVRTGNYKVLLIATQNISKDEELFLSPMDFKRYNGEKDACSCAKEDYCLYPTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW10</accession>
    <name>L7JW10_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1545"/>
    <dbReference type="HOGENOM" id="CLU_399115_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW10"/>
    <dbReference type="OMA" id="EEWECEN"/>
    <dbReference type="OrthoDB" id="10614129at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="629"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="690" mass="80837" checksum="B7B7A17AB8D621C4" modified="2013-03-06" version="1">MVYTPSMNQWYVKELLSLGRYDEALEYLYGVLKDYEDERVDYRIDIKDRELKDKELKERDLEKDWKDRDRKDRDRKDKDWRERDLDKDWKDKDWKDREKTLKEKENDKKKENDRKNNNDRKNNNDRKNNNDRKNNNDRKNNNDRKNNNDRKNNNDRKNNNDTNTNKDTNTNKDTNTNKDTNTNNKTERSSIHALLGAIHLKKKDNNRAIIHSIHSINLTEQPLALSTLASAYINVGDYRRALLYSKRYSVMMDDYESRCRYAALCIVVGRGGKDGDGYGKDRYGEDDGDAVGSGGKDNIDGDGKDNIDGRSKENIDGRSKDGKDNIHNIHKENNNLNNERLWMKCCRRERGSNHRNDIFRAEVVDELPDEGNEREDMNEGNEREGMNEGNEIEGXXXXXXXXXXXXXXXXXXKNEREGKNEREDTNEKDVQYDPTKEINQPSKTTIKTLHRQAVLSTCTHHINTRQPVPETDREHFIQKYTDQLSNGQFMQAIHILQMIYAVKERAQLVPHLIKTEQTAVLRMMLHANTCTCVKRSVGMMLERIVCNQKRCRYEMVLFMLMNGHEEMVNELMYEIDEVNEDEWGKEVEGNDKESDDEEDDDEEGNRIKGKGSNRIENDTYEGRGRIGGSNTNTKTKINNIKNINSTSTNNKNINTNNDKTKTNTINNTNDVNCNNHNDELWRVLNEWQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW37</accession>
    <name>L7JW37_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA+-type ATPase</fullName>
            <ecNumber evidence="6">3.6.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.3" evidence="6"/>
    <dbReference type="EMBL" id="JH993936">
        <property type="protein sequence ID" value="ELQ75644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW37"/>
    <dbReference type="FunCoup" id="L7JW37">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1397"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_0_1"/>
    <dbReference type="InParanoid" id="L7JW37"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036266">
        <property type="term" value="C:Cdc48p-Npl4p-Vms1p AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030894">
        <property type="term" value="C:replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140624">
        <property type="term" value="P:EGAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099638">
        <property type="term" value="P:endosome to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902979">
        <property type="term" value="P:mitotic DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010636">
        <property type="term" value="P:positive regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990171">
        <property type="term" value="P:SCF complex disassembly in response to cadmium stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="243"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="516"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="795" mass="88381" checksum="734B3B7E9C32FEA7" modified="2013-03-06" version="1">MSEKKNNEDYISAILENVTDNSCLVLDPPPNHELEINELGMSAEMANCHRVRDGNHIIARGKGRRECIFRVRVFNSKVERTIYLSKYARNNLRVRIQDIVKLYPCSSLIKVHAAVIKPIADTSKNMDEEALFVKFIQPYFTKPLVPISKGDIIPITCGMMTVDFKVLELSSPKDTNDLKHGLITAETKILCKGQVDREAAEADFKSIGYDDVGGCRRQMAQVRELIELPLRHPALYTSLGINPPRGILLFGPPGTGKTLIARAIANETGAFLYVVNGPEIMSKMSGESESNLRNVFKEAEKNAPSIIFIDEIDSIAPKREKSHGEVERRIVSQLLTLMDGIKKATNVIVLGATNRPNSIDPALRRYGRFGREIEIGIPDKIGRLEILRIHTRNMALAEDVDLEKVANETHGFVGSDIASLCSEAAMQQIRRKMPKIDIESDQIDPEVLSSLKVTTEDFTYAVDNTDPSSLRETVVETPNVKWEDIGGLQAVKDELKETVSYPIKFSEKYVQLGMTPSRGILFYGPPGCGKTLLAKAVASECSANFISVKGPELLNMWVGESEANVRDIFDKARSSAPCVIFFDELDSIAKSRSNSSSDSGVTDRVLNQMLTEMDGISAKKNVFVIGATNRPDQLDTALLRPGRLDQLIFIPLPDQESRHSILKATCRKTPLNPDVNLKIIAETTKGCSGADIAEIVQRARKFALKESIQRDVSKLASIREKGGDVDEEDIDIESEPLTVGLRHFQESLKNTRRSVTQKDMERYESFARSMNINLNVSSAERQQGPDGNNVEDLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW68</accession>
    <name>L7JW68_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1788"/>
    <dbReference type="HOGENOM" id="CLU_3191632_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW68"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="46" mass="5285" checksum="5E870DB24596C2C9" modified="2013-03-06" version="1">MNSNDQQLIDEFEELIEDTEQRNDTLENAISDMIKNKTSNGEKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWB9</accession>
    <name>L7JWB9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1732"/>
    <dbReference type="HOGENOM" id="CLU_1180921_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWB9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979197" evidence="3">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="235" mass="26975" checksum="9AFC4D247C039B0F" modified="2013-03-06" version="1">MFKSFLLFSLFYFTIISSMNTNKTKNVKLKENTSSNKTEKNALQSDETPIRHSHAGSHTTGTNMKGYILKSVIKPEPEKHSSSIKTNETGKEKLGNRSLSGVASKNANLALQNDDEDHVFLLEQRNTCSNTDTHTKRNMSKKMLTFNYLTRKKNETKKSAVIPEYNPNKRELQAREAFRPERKQKCFARTPVFLGMAIALSLSLIFTVSYVIYLEVTKIIRFGWFHKTYSNDYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWD3</accession>
    <name>L7JWD3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1239"/>
    <dbReference type="HOGENOM" id="CLU_1760191_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWD3"/>
    <dbReference type="OMA" id="QCTADEP"/>
    <dbReference type="OrthoDB" id="10273792at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="178" mass="20741" checksum="2D303F9C4D8034BE" modified="2013-03-06" version="1" fragment="single">VYRTIKKITPLKTHRIRSTLEEQPLQKKGQFILPMHERTRGGKAKMVFEPRARKTADEPQLEQHVLANEHKEGKTDNERLLSSIPHINTQRLKKPARKELGRVHDEPVYRHVHAEQCTADEPFDIYAHAFLVHADRQMLESERFVIVPVKDDEMHAYVFGDEVVFLGDVRAVFTCVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWG2</accession>
    <name>L7JWG2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-type ATPase (P-ATPase) Superfamily</fullName>
            <ecNumber evidence="10">3.6.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.4" evidence="10"/>
    <dbReference type="EMBL" id="JH993993">
        <property type="protein sequence ID" value="ELQ75087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWG2"/>
    <dbReference type="FunCoup" id="L7JWG2">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1969"/>
    <dbReference type="HOGENOM" id="CLU_401807_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWG2"/>
    <dbReference type="OMA" id="CGWLIEK"/>
    <dbReference type="OrthoDB" id="2192425at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="694" mass="77728" checksum="A2E303B1D43807A7" modified="2013-03-06" version="1">MHKVFYTLKIANITCGSCIPKIQKCLRGLEYVNDVKINIFTKEVQLEMHTLIDSAKIKHIKRALNENGFTVSDNKKYWRNTFYTLSMLYIIQTVIHKTLSIFWVDLVFSTIIEVLCSKRILKGSMAFTDTVILGSHASFVLGCFYDEQNLQNSSLILVMIVLGKFMLETVGNRASECLRSGVTERYMYNNKNLNYEEIKEGHVIVVEKEKHILFDGIVMEGASYVDESSLTGEIKLKEKKKGDHIHSDTYNKTGRIIVHVRRVGEETSLGKLLKQIDHSSVSNTNEITGLFIFIIFVTIGSFMLCALNTPLAQAIETSLSLLIIACPCALNISEPLTILIGTKKLFDNSIVIRDLAVFENLCDIGVLFIDKTGTLTDGTFIVKDFINTSSLDISTVKTLVHTLERRSYHPIASTLTEYCMVSAMGEVLKYEMMSNGIKGRVRYRNAHYDVQIGNDGLLSANIKNGRCFETNRSIKDENYETDNVPKRINDKNYALYTPDEDLISVYVIVNDELTCVFYLEDKIVNGASSALKLLNEQNITTIMLTGDSYRNAMRIAHRLNISKVYANKTAIHKSNIIQNYRKGHVVGMVGDGINDYSAIAHSNVGISVGNVFSGIGHVSLLSKDLHLLYLLLVIGKRIKRRITINYTFSIIYNVAALCACIAGGYYGLVITPGISCICMFLSSLTVVISALTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWL3</accession>
    <name>L7JWL3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1347"/>
    <dbReference type="HOGENOM" id="CLU_940730_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWL3"/>
    <dbReference type="OMA" id="VFIAQLM"/>
    <dbReference type="OrthoDB" id="2189981at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="296" mass="33808" checksum="655D3FDE988D663F" modified="2013-03-06" version="1">MKIGQIVLGQLLAVAIALVSKSSEKMQKIGPFWIFLQDSARIAAIFLFSTIIIFANKGQQKKGTVPLYNFIICAVTDILGNAFLIYGYSQTASYFVVFIAQLMYPMMIITTKILFNRNPEMSIFKIVAFIVLVVSCFVVNKYNHNEPLENILKGLIFVFLSNSFFIANIVLQSKIVKVIGPFPYLKKVNIVSFVLSPMINFVVNYRNLPKSVDEVLSFYKLRYHWIGLYTICISAFYILGTFYIEWNGPVPFNIATLPFSAYFGLINIYETFEIYVLAAYIICITASIYLLYKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWM6</accession>
    <name>L7JWM6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-directed DNA polymerase, putative transposable element encoded protein</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JH993908">
        <property type="protein sequence ID" value="ELQ75883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1160"/>
    <dbReference type="HOGENOM" id="CLU_2559917_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWM6"/>
    <dbReference type="OrthoDB" id="1421278at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="82" mass="9623" checksum="C226BC963EE3DDAF" modified="2013-03-06" version="1">MQKISDWCKRWRMSLNIGKCGTMVFSSGEVCKICYKEQPIATVDSYKYFGLPLMPDLDLNVVVRDRKEKAIREYHGMRPFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWN6</accession>
    <name>L7JWN6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWN6"/>
    <dbReference type="STRING" id="72359.L7JWN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1211"/>
    <dbReference type="HOGENOM" id="CLU_1316226_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWN6"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phenylalanyl tRNA synthetase beta chain core" evidence="1">
        <location>
            <begin position="50"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="23055" checksum="598207BE8A045804" modified="2013-03-06" version="1">MGSSPVLKGPKGVDASSPVIKNRPVKAKIEVLDKDSNLLNINLSRLALERENGGCVELLNPKSKEYQVMRSSLLPGLLKFIKKNAYHRPPIRIFEVGDVFNINGDSDTGAINCRRIAGAIAGTTDGLSDLIAFINQVLTKCKVNTRFVRKEKSVFLEKRGGRILCDDDVIIGNFGVVHPRILKFYGIGMACSIFEIDLDNLLKIMVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWP2</accession>
    <name>L7JWP2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vesicle coat complex AP-1/AP-2/AP-4, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWP2"/>
    <dbReference type="STRING" id="72359.L7JWP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1877"/>
    <dbReference type="HOGENOM" id="CLU_317655_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWP2"/>
    <dbReference type="OMA" id="INKQMAG"/>
    <dbReference type="OrthoDB" id="10357717at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="43"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="924" mass="107683" checksum="2B5174A0BC422227" modified="2013-03-06" version="1">MFTDKLLDKLMNVINKQMAGTKIQLDNPTPNQLRDSMMVLTRKMHTEDVSSYLTKVIRHIDTPNLFIKSLINYYLINIKHNTTVLMLIINTTLKDLSDNDYFKIQGLRVATNIKNSDIQQFFVARIHKLMSDRNFVVRLCSVIASISIFEQNYDKFMEYKFGEQLMRMMGDSVLAVRECVLMAISTTDVEVNLELFVSNFEKRSENERIAILRIMKKRLERAKEGQPDFRMVEEDDNGDLISISHQDGRKIRDNTMCEEHNKKYGGVKGTFWLSKMAKKFLTHALRSQNHVLAIFAAEILVHSKVFHHMIFNSLVYFLDSIYSQYILEFFLEHNLNYDSRLFFIYQSDKEEIKRLKLLILCNKRDEIAIEEIKRYHHMFNNEILECLILKEHKDLGLIIRIIACGLQMDSNRNGERNNGNDGEKRFFVDEYLNKSTLEMLVKLQPKITFDISEVLSDIEPKNDDITHFLVLAQHLLPYKPKTVEYIEKQKLTFLQCTELLNFYLSLTKRGICLDVPDIEWPSALIGRVNLLREYNRREHHLLNICQDANIELEPFPDTNILPNNMSLNERNDETIIVDEDDHQTAAKTDNIEKTKSMVYNTQKLDGTNDSIANNELSLQNISPQIGLGIQNGSPGQNTMQIDRPKKINFLEINNCKDELLGITGLETQKDISTMMDTKILASSNPVLEQNYQPELENMQVCGGDSNQEIYNTANLTKVHTEILSTEGKERIHASQKIFPVPEDGAVVRQEDNEEKTTNYLQEVMHLDTLSNEYFNGIIYLAERMLFLDIKELKKKFRFTYNNRGITVEKAQRIGIKRIKEDDINKVINYKTNTTFCRLHLCISKFIKPKEVSMEEFIQNFNQITDYEVLSADIINYLDVYFLDGKKFSFSVFDKCFYGEAFSLQAIVKSSNRKYLKMIKAMRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWP6</accession>
    <name>L7JWP6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1525"/>
    <dbReference type="HOGENOM" id="CLU_1972016_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWP6"/>
    <dbReference type="OMA" id="AISCKEM"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="127" mass="14930" checksum="CD64C870DBB30C20" modified="2013-03-06" version="1">MSLKEKYEFFTKDEPLTKDSLCNLLSLCNRVPPMMDDISSLPKTFEEFEKLAISCKEMSNQKDLLKHLVAFNKGNVCMEKEQFERLLSIGEEFSEEQREELYKFVNVKDDMINLEEFVEQITAEVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWQ0</accession>
    <name>L7JWQ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1530"/>
    <dbReference type="HOGENOM" id="CLU_1103420_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWQ0"/>
    <dbReference type="OMA" id="CKSETGY"/>
    <dbReference type="OrthoDB" id="10347249at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="252" mass="29814" checksum="08A08D536054372B" modified="2013-03-06" version="1">MNHLLDILFTLTIIIINTVLYYRHTIKKRAIIQKMSSTTPSSLAFSSINQHILSYESESLALILNFKKEFDIFHYCTSFTDSYFIFTGYVDIEWLNCYLGVRNKNSVHALKYLEKCKSETGYYGTYNKDVLMFYKKHRLDRFYITFIPRSINDTNFDGIIYAEGKIGNVCSGFVDDIIALIACLRKVEPSDRLKENNNMIKKRILYEASKQKDESNKKNVEDKDVKRRERENTGYEKKKDEYKLKTRYLHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWZ1</accession>
    <name>L7JWZ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993898">
        <property type="protein sequence ID" value="ELQ75949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWZ1"/>
    <dbReference type="STRING" id="72359.L7JWZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1086"/>
    <dbReference type="HOGENOM" id="CLU_085472_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWZ1"/>
    <dbReference type="OMA" id="MINASFW"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="5">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="226" mass="25737" checksum="A4E723F67E8C2197" modified="2013-03-06" version="1">MPLSDNQGFIPSSPKPDYTPKSLRTLSIKQLKSLPTDTPTHTIDNTTLSTICVAGWVRSTRQAQSGTIFLLDDGTAMINASFWPNGLFEEEQAGLIEPSNFLRVIGNVRVYDGDISVSVSFLTKIDDFNYVSYHFLNVLQQHLYCRRELKRDTRKNVEKGMKTGTLQEDVLMCYRNNQDEKGLHVDLVVKMLQGKYKEQDVREMVNSLLDDCYLFSVDGMCYKTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX24</accession>
    <name>L7JX24_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH993913">
        <property type="protein sequence ID" value="ELQ75855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1182"/>
    <dbReference type="HOGENOM" id="CLU_2252098_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX24"/>
    <dbReference type="OMA" id="MNTVYRD"/>
    <dbReference type="OrthoDB" id="10295270at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="112" mass="12909" checksum="F83DFCA6439D382F" modified="2013-03-06" version="1" fragment="single">VPLFTEMNLILKNKDSIIFEKHPCSYESSPIFTNLLHSLNEVAKKYFNSKLLSFEIGPNLVEYYRSESGVVIIWSGTKEQKLDMNTVYRDYADAVLYGDIKLFTDKYGDAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXB4</accession>
    <name>L7JXB4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993897">
        <property type="protein sequence ID" value="ELQ75955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1084"/>
    <dbReference type="HOGENOM" id="CLU_2442428_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXB4"/>
    <dbReference type="OMA" id="IVRQCEF"/>
    <dbReference type="OrthoDB" id="10438843at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="90" mass="10633" checksum="51ACF44E0629DC2A" modified="2013-03-06" version="1">MQANFDDGINETLATLILRQSTSFDLTLLSMFTFPVLTHMCLKISDPYERGQDEEFCKDFYSQIVRQCEFLRQLHFIFKCSQLHLAFKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXC2</accession>
    <name>L7JXC2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0914"/>
    <dbReference type="HOGENOM" id="CLU_1662039_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXC2"/>
    <dbReference type="OMA" id="DKNMTNT"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02066">
        <property type="entry name" value="GRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012519838" evidence="1">
        <location>
            <begin position="16"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="55"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="159" mass="18885" checksum="16E8558F8C368EE3" modified="2013-03-06" version="1">MFLFFDIVLSKGLLSSLFDSIKFENYENFVDEARYDAEIKTNDSALIDLMKTEFVVFGTETCGYTKKALTLLKDKGMSYVFVDKDKNMTNTYEDLKKDLRHETLPLIIRNRRFFGGYGKLKEYFENPYEFYKKYYEKYYGKNYGNTYSTSSEISSFPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXF6</accession>
    <name>L7JXF6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Structural maintenance of chromosome protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXF6"/>
    <dbReference type="STRING" id="72359.L7JXF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0998"/>
    <dbReference type="HOGENOM" id="CLU_388397_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXF6"/>
    <dbReference type="OMA" id="YYQINTI"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="232"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="544"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="370"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="483"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="711" mass="82705" checksum="C823C7FDE1A1C100" modified="2013-03-06" version="1">MHISSVSYKNCKMEFSKRINIIGGNNGAGKSVLLTALDTCVTNTDTKNDVITDITFGGEAKESAKVYYIRQNEKIHDENKIEEKVKEQFNYYQINTIIAEIFSNLNIENDDLMYKLKKVGIKVKNNLQKFLAHRKLMKEKRKIENYIKMKESAELCKKIVEVQDKICQEEAVGDNFENDVLLMKKDKLEKEIAWLKKETEKDDVMNDLERKKVLWREESKLKENLKKYRNEKRVVDLIEVDDNAINAVIAVIGNRLKCMVVDYEEEALEKIKSLRFRQSFIVMDKIEDVNDGEEQNESMVPLKHLVKTKKEYNRLKEFLFKDIYLVKDLTKVSASNKILVTLKGEVLHKSGAISGGYDENKEYMNLFIEKLEYKKSLERLKEIEKELKNMKNSESDANRKELIKKIIQEKEEELQKIKISSNYININLERLKLVLNRLIEQKEVLGSFRDEDITGLEDVNLNEELGRVNKEMREIMISKRIDYEDVGARIEKLFKRNEELIKNKKKIEKMADNLKKENEDEILKHVKEVREKLVVYYHLISGKEETSEETKNSSSDVKKNDAADNNISFDKGDDVDVENNKNNYQGSITDTHDHQNATSAMDREGKSMTKPDDFLSTIGMLSGGQLQILTISLMLSLNDILKYDIVLLDEIDSNLDDCKIQNLTKICTKLKVQIFLITHRKNSLVGDKYFWIEKDSVSEISREDMEARIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXF7</accession>
    <name>L7JXF7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mRNA cap-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXF7"/>
    <dbReference type="FunCoup" id="L7JXF7">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0910"/>
    <dbReference type="HOGENOM" id="CLU_043552_7_0_1"/>
    <dbReference type="InParanoid" id="L7JXF7"/>
    <dbReference type="OMA" id="KTHNDSM"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="182" mass="21470" checksum="55D1EEB23076A8CE" modified="2013-03-06" version="1">MTHPLFVPFTIKTITRNTTKKEPFDFCNSLKKLCTLRSVENLLYFLNHVNFDHIEGITDISIFKEGIEPLWEDKSNISGGKWIIKLRREVSTRLFQKLLIRMVRQPFDKIDVNGIVISFRMKNVILAVWTKDSTGKDRFKDVLMEIKKVLDIKFFLSVEYKDNDESLKDNSSFRNTKNLYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXM3</accession>
    <name>L7JXM3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome Assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993860">
        <property type="protein sequence ID" value="ELQ76198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXM3"/>
    <dbReference type="STRING" id="72359.L7JXM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0808"/>
    <dbReference type="HOGENOM" id="CLU_787757_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXM3"/>
    <dbReference type="OMA" id="WEYHKYL"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="316" mass="36414" checksum="0FD4F5E1DEA329E7" modified="2013-03-06" version="1">MSDSTSEYEVYYPENDLSVQLEVNSEAYSYLEYITLEYPSQTVITHRSKVLVAQGGKHPTIVELKFKNLRKNADFKHKKAKIRGNINRIRSNSHLIVAVGDDKAFFMDNRLEKEAELFGPFSYGLTLTNEYIFMTTRSGEIIKMDIVDQSKNVLKVHEKGIDGLAFVNDLIFSASNDNTLKITDVRTGQTVYTYQSDNNINSVDATNDNFLFGDDSGTVFLNEMRNFKNIDQIKWHKSPINAVKFKNADVFCSLSDEQVCLWDKSFEEEWEYHKYLYFVHQGQSYYKECAFLDDFIITTSQDGLAIFKPIEEVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXP4</accession>
    <name>L7JXP4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993863">
        <property type="protein sequence ID" value="ELQ76174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0847"/>
    <dbReference type="HOGENOM" id="CLU_2074780_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXP4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="118" mass="12848" checksum="72A2B91FBD74551E" modified="2013-03-06" version="1">MLSLEVLEVITGCVWAGMLCMAVKVWRLLDGKLDCGLVRMMGMLILLMLRLFMKIRLEGGVGGSRDVGGDRDGGVGRGRNGGVWRDRNGGVGRDRNGGVGRDRNGGVWRNPLGRDYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXP7</accession>
    <name>L7JXP7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L35A/L37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993950">
        <property type="protein sequence ID" value="ELQ75532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXP7"/>
    <dbReference type="FunCoup" id="L7JXP7">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1516"/>
    <dbReference type="HOGENOM" id="CLU_100745_3_0_1"/>
    <dbReference type="InParanoid" id="L7JXP7"/>
    <dbReference type="OMA" id="VELFKMY"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="13885" checksum="DA550A651BC73E6C" modified="2013-03-06" version="1">MQAQSQYAFVKQHLLKDTLSALGKFISHRRAQRRLHPSECLVRIDHVHTAQEAQKYVGNEVELFKMYVKDSNNVVKSVKGRVVKVHGSRGVVVCRFDRNLSPTEVNTRVYVKLCRAEEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXT8</accession>
    <name>L7JXT8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-dependent protein kinase types I and II, regulatory subunit</fullName>
            <ecNumber evidence="2">2.7.10.2</ecNumber>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.10.2" evidence="2"/>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXT8"/>
    <dbReference type="STRING" id="72359.L7JXT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0722"/>
    <dbReference type="HOGENOM" id="CLU_075121_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXT8"/>
    <dbReference type="OMA" id="QENKWNI"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="119"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="304" mass="35244" checksum="6A2A13D3AB1E29E1" modified="2013-03-06" version="1">MNEDEINAVINAKIDALPENERETARYDILYLYNRAINKQEQEGDRYGILTDISERLVHFRLNDLQAVEDACVPRATDEQISMAKRKTIIGERVGKNKRFPKTDEQRRMLNQIFKNTFLLSFLNLRQRRNFVECMQPFDTHKDEVLIRVGDNGDRLYFLERGKFCVQGADGEKELPLHSVIGEIALLHNVPRTATVVSRADGRVWYLERESYHTIRMFDQENKWNIFVKRMRRLNRNVGELASIATGVFVEEGKAMSLEGRMMVVVFDCEVRVGGETRALNAGDIMYDDFVAVSEVEGYVLPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXU0</accession>
    <name>L7JXU0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_1476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993942">
        <property type="protein sequence ID" value="ELQ75572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXU0"/>
    <dbReference type="FunCoup" id="L7JXU0">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JXU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1476"/>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="InParanoid" id="L7JXU0"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ75572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="849" mass="94566" checksum="4D63BA545704171E" modified="2013-03-06" version="1">MAVDRQMLKVQTLMNNQPNIRNISVIAHVDHGKSTLTDCLVIKAKIASEDASGKRYMDTREDEQERGITIKSTAISMNFMMNNKVLSEHMKQPFNGNSFLINLIDSPGHVDFSSEVTAALRVTDGAVVVIDCVDGICVQTETVLRQAIAERIMPTVVLNKLDRALLELKESKLDLAAKLRRRVEDFNAKLQMICQGADDFHVESLFPQKNEISFCSGLQGWGFTLKSFAKYYIKQMKQENKPNPETFVCKVLWSEGVYYSSDDPFDPNGKFLKEGPPERSAFIVFVLNPIYRVKELCENLDEKGLREYLSKFDVTLPATINYNEMKDLFKVAMRTWLPASDMLLEQIILNLPSPTVAQKYRAPHLYTGPIDDLAGRGIASASTSPDDPCVMYVSKMVPYSENRFIAMGRVFSGVIKPGMKVRIQGPDYTVGSKTDLHVKTIQRTVVMMGRVVKDIDECPAGNIVGLIGIDSELKKTGTITTWDGCHNIKSMKFSVSPVVKYALRPANPVDLPKLKAGLIKLSKSDPLTQVNFSDNGELTLAGAGELHLEISLEDLRKEYACCEVISGEPQVTYMEGISATVGEPKMSKSPNKHNRIFMCIEPMEEKLVENIENGALCVKDPKERSVRFREIMGIKDEWVKKILFYGPEDKGPNIVIDSTKGIAYLNEIKEYMREGFREVTARGPLIGESLRGCRFDLMDCTLHSDAIHRTGNQISAPMTSVCKGLILAAEPILYEPIFLAEISVASDQIGGVNSVLSQRRGVAEEYKCDGGMRTIITGYLPVRESFGFNSALLMATRGEASVVLTFSHYSVLPGSLSDTNSLLHDTVTSVRKKKGFVELKGADYYFDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXW4</accession>
    <name>L7JXW4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1455"/>
    <dbReference type="HOGENOM" id="CLU_995917_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXW4"/>
    <dbReference type="OrthoDB" id="10482776at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="280" mass="32720" checksum="FC26E48FD7453609" modified="2013-03-06" version="1" fragment="single">VSAERRRRVRIHDKSGNLVKEIKATSNSLVRHENGKGNEFLVITGNKIRIYNGPEMLDEVEHINDINTCILLDKKIMFIDYKGNYVLYNIGKKKKEHFNVGRVFNRENENEKFKAFLSGRGLDLCPFSMRICNNALVFAGNFFIFIEKYKIKDKEIIINELKNNRLNINYILQYNMSVNILENLLDNRIDGIEVTKQDGMIALSKPFLSTISMGNRTKYVNYLKKYINYSKYIGITQVLIKECLDAGMRVDYDISRVVDWVENVHRDLIGMKLLFKNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYK6</accession>
    <name>L7JYK6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993919">
        <property type="protein sequence ID" value="ELQ75822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1215"/>
    <dbReference type="HOGENOM" id="CLU_794996_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYK6"/>
    <dbReference type="OMA" id="NCDDDRR"/>
    <dbReference type="OrthoDB" id="10533687at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978998" evidence="2">
        <location>
            <begin position="18"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="357" mass="41179" checksum="DCA87E5C4D519269" modified="2013-03-06" version="1">MFFGVLFIFFLIYLSKSVSNRAKSSSVNKVRKEDTHKPKTGYAKKTSYPDYVSKNKILRLSLANDTKKRLRYVIGEGFRVTKTDDTPESIRTNKDRSESSLVVFRPLGHDRCAVIVDKVRMCFKATGDERIGNCDDDRRNINEDHGWNVEKINDNDVILTNEDDMGEKLCLTTIANGKISMRECDDPYYNDQAFNKSHYTKDTDSKTEDIEEDFEVEDKRTKDNSMENDDNNNDMTEKLTRRNAPFSKGAYKRNPTRAPNRDHISDKNPQKDLNTSKISSKPEDLDPAVRQIYDLLKDIREGIDEKMKEILANPQIVDANEIIGNLLTLKNANMSPEYRQENVLGRDTGRYYYPYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYL8</accession>
    <name>L7JYL8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993918">
        <property type="protein sequence ID" value="ELQ75837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYL8"/>
    <dbReference type="STRING" id="72359.L7JYL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1209"/>
    <dbReference type="HOGENOM" id="CLU_1972015_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYL8"/>
    <dbReference type="OMA" id="ISKERNP"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="127" mass="15178" checksum="7028BDE03D96533E" modified="2013-03-06" version="1">MLDRFSILYHRIQCRICALRFTDTDQGKTQYGMHIEEHNRRKRAEQHKDTISRTYFPNEDNWLSKKIELPVARQEEHKLFVSKKLVVCNLCNEKMDVEWDDDNDSWMVKDAVKLGDGNGYVHRECAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYP6</accession>
    <name>L7JYP6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993869">
        <property type="protein sequence ID" value="ELQ76151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0885"/>
    <dbReference type="HOGENOM" id="CLU_1670621_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYP6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="158" mass="19274" checksum="EA07599704E81076" modified="2013-03-06" version="1">MFNLRIICTQKRDILYGLCEETSCIVCKEEFNTMLTIERITTFEKCCTYFNNYLMEMDKLFMKRRKFTFLRLKNVLNEQKAEMIYEQMLSWFDTGEYLRRFLKIMSMKDKRTIIRLNNGRMKIIVDIMYRMTKRLRYLTVSVNSLLDIRQLAITTKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYU0</accession>
    <name>L7JYU0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993862">
        <property type="protein sequence ID" value="ELQ76186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0835"/>
    <dbReference type="HOGENOM" id="CLU_2414859_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYU0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="92" mass="10615" checksum="0518F7B9FC843F1A" modified="2013-03-06" version="1">MIKKSPLTDSNKFSYKANVNVLHLKESSNSESLKILVVSCCDRSKAKMVFGETHARKMKLDKLIKKNFLNQLFVLYNQSYLHKQRIGSHDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYZ5</accession>
    <name>L7JYZ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993838">
        <property type="protein sequence ID" value="ELQ76550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0461"/>
    <dbReference type="HOGENOM" id="CLU_2172830_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYZ5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="110" mass="12923" checksum="B24C6E460E80B757" modified="2013-03-06" version="1">MPIQTRTTMNDTAHTTTNNTTIPQTRGNISFEVDMHMFIYMGVLLTVFIIIMCMYYACIRETQDAVIIQNVAYTRERRRPKRLDTVFEEQDDDEQPNQSEIRSPDRETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ90</accession>
    <name>L7JZ90_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">[RNA-polymerase]-subunit kinase, cyclin-dependent kinase</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ90"/>
    <dbReference type="STRING" id="72359.L7JZ90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0359"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="L7JZ90"/>
    <dbReference type="OMA" id="MVYDESL"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="296" mass="34107" checksum="A6CFA611AF2FDF0B" modified="2013-03-06" version="1">MSLTKTSEIFKISQYVIQKKISSGSSATVYLATKDEKFYAIKKPYILTFSDPNNVRLSSENEISILKELRHPNVINLHDIVWENNSQVYLVLEYVPYDLASVIRDKKNLKLTKTEHKNWLLQIASALSYMHAKGIIHRDLKASNILCSNNVVKIADFGSSRHIAGQMTGNVTTLWYRSPELLLGKTNYGEEIDIWSLGCIAYELICGELLFIENTEIQMLDKIFSTFGFPSTVIAPNLCYLRQMNHHTYHFDDILRDKCCSEEQVQFLERFFVYEAEKRVTAKGVLQSEYLNIKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ96</accession>
    <name>L7JZ96_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ96"/>
    <dbReference type="STRING" id="72359.L7JZ96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0364"/>
    <dbReference type="HOGENOM" id="CLU_465535_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ96"/>
    <dbReference type="OrthoDB" id="2187603at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="586" mass="67800" checksum="7E4EE676E9FD8E44" modified="2013-03-06" version="1">MLADHIYPYEQRVLCVSLKYSIIKYITICQILNLTRDYIEEWNFTDLLLKLNLKLLLENVIFGAERKLDTLFLHALQTILNNISGVVNEEAEALKCCNNHSDCKLEVKVTNSANDSLFSSSSSKNSQIIDIIYTNLRRMYAESSDYHTYMVLKQINFENLCQLKEFKALLNKNEEGVKNNDVKLEHNFYNRSNKEKFYNISSLSGDKSILAKKPVDSRNVGGEDFENSQDKQTHMVQGVRTDQNHPTISDTKHLYNDNTRLNTFNEPINTEALHNVNTGEESDFKNLNIGDIDDTFSNITLNNAKIKTKTGHDQDYPNLKIELLSSNQKQRLLEFELSKNDPNREIVSYCLKALLNDYKYASGMVFNKSKVVIRKKLSNFCLYCNFYQYDKIGDQLLFKITAPGGFTALIVRNGQLLKIQVEKGVENVVLLPSPVNNLYALGLEYNNKVLKIHLNEIKLPVTIKGAKLLEVGENFRGIIPRIVYYENVPYNEKYLENLDNISYYAKYINELEKICQYYNHNGVIVDSSMPYFLSKNSFHVNVDNLMINTLYDFLNSEGFTKAFLEKLKKDAEFRSILEQYYMDYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZB0</accession>
    <name>L7JZB0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993852">
        <property type="protein sequence ID" value="ELQ76386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZB0"/>
    <dbReference type="STRING" id="72359.L7JZB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0632"/>
    <dbReference type="HOGENOM" id="CLU_545844_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZB0"/>
    <dbReference type="OMA" id="HGRQSDQ"/>
    <dbReference type="OrthoDB" id="763901at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="500" mass="55067" checksum="632BC1770DF3EBB8" modified="2013-03-06" version="1" fragment="single">VCKAMRVTLPLLYCCIVYTRLIIVNDLGKNLGKYGKLSRRRFRSGKNSNDGKNGGDANENKEDGKVDGTAYNDKDNAEGNNTRNGRNNDDNGKDSGETGNNNNRQDRNSTESNINDKKGDNPSNYTNDRNDNNKQTGDKKNNPKTEKNSLLNNELREDIKSINDLLKELLTKKEKKNDGDENDKGKAVPNIVISHQGNGNDDNSSPGTSSAQTPGSNGINDAGNATPSTTAPSASPTSSTSFGVAPNTAIPSTPPPSSGTSPNTPTPTASSTPNPLQSLSDPQDTLIDLLLPQQSPQSSLNSLQSLESFSRRTFNQATQRKKQLKKKQASERLATIDRLQHTLQDKINGLKERLSSLQAQLENAKHDLSTLTSMIKGLEESASSVSKRQERNNARIRLLNNELSAINKRLDSLNAEIALKKDEHEIYAHNLRNLEERKEQMMDKKEKVNVMMYGLERDINTIKDRICAMVGKKGALDKEKSAEEQKKVEESINSDGYEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZB6</accession>
    <name>L7JZB6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA topoisomerase</fullName>
            <ecNumber evidence="3 11">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_0187</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 11"/>
    <dbReference type="EMBL" id="JH993813">
        <property type="protein sequence ID" value="ELQ76798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZB6"/>
    <dbReference type="FunCoup" id="L7JZB6">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0187"/>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="InParanoid" id="L7JZB6"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="15">
        <location>
            <begin position="153"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="752"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="805"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="625"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ76798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="848" mass="97971" checksum="7FE82DC1B29300FB" modified="2013-03-06" version="1">MKILNIAEKPSVAKSITRTIASSASAARTKYKYTPVHKFTYNSDAHLFTSVLGHLYTQEFTDNRKWTECDPLTLFTADITEYIKDEFKALKENLLHLSTGVDKVVIWTDCDREGEYIALEIQKLLNRKCWRARFSAITRDEIVRAMENFQEIDMRQCDSVAARMELDLRIGASFTRLQTLNLAAHKNVVSYGSCQIPTLGFVVERALEHKKFVAEKFFTLKICIVKDRHTNIFSWTRGNVFDKNCVLYFFRYLTDELAGTVVTGVEKKSVTRYRPLPLRTVDMQKILSRSMPSHRIMQVAETLYQRGIISYPRTETDCFPRNFEYNRIKTEILKAGRHNVANTAFRGPRSGRNNDFAHLPIYPLKNPANLTADEKKVYNFIADRFIASVSEDALLEEHVVHLRMKDEHFVLKGTKVVKHGFLKFYHHDRVGEKDISVFREGERFELSKIERICSLGEDEKDKPGNDRDDASEDVIIVNEAPGTLRDEHRMNKNCIFVNDGTTKPPNYLTESELIALMDRNGIGTDATIHEHIKKILDRKYVSKRTKYLVPTNLGYSLICCYKTLGLNLERPHYRRDLEKSLKDIEQGVVDRMNVVERELECYKRFYLILQNNLDVMKDIFRTNHDDDSDFSGGSSPKSRGTGTYAKRIGTGRVVRGARKEDEDRTRCSDEHPYDVKSGQNKFMDGVEEQQYTDNGDNGATCRLPQIKNQNKTTGRNVLQSIVNDIVSIKQNRMERKENNAGAYVTDDENVFCDCREKAKANFVKKGKNKDKEFYSCAKFPDGCNFFQWKGLRKLRDEFGPNGVKCLCGAGVRKLISNTDKNRGKAFYKCNKRYRPCNFFMWEDEMADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZC3</accession>
    <name>L7JZC3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993851">
        <property type="protein sequence ID" value="ELQ76401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0631"/>
    <dbReference type="HOGENOM" id="CLU_825297_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZC3"/>
    <dbReference type="OrthoDB" id="2199714at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="337" mass="39192" checksum="5FC79B64EFCAE4CD" modified="2013-03-06" version="1" fragment="single">VVEQVETPSIKGKLNDVFEYFITSLFYDLLVGEFSNKVVCMTRANENDVNVSVLISGLEYEEANEILKRPSLLVQKYVFENMDIETEIQTKNVKEEVVDDNVTNNDNRGINCTESDVVDEKEEPFDENDSCADKENMNVSVEKENYGNIASKRRIEEKKIEQNEGECIHDVKGENEIENEVNESHTIEMRASDENRKDKNKKSVFRKVQDKLKSWLKKEKEEVHETEWEGDPGYLIFGSKSGHRVIITKKIKLEKCFSFDTKKDLEILDDLITDEHFYVEIQSRVKVFIVKEDDMRIFMNANVSSDQEEFLENVENLGKKMEKVKAKRNSEIKSVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZD5</accession>
    <name>L7JZD5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
            <ecNumber evidence="6">6.3.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.19" evidence="6"/>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZD5"/>
    <dbReference type="FunCoup" id="L7JZD5">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0228"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="InParanoid" id="L7JZD5"/>
    <dbReference type="OMA" id="MFEWEVM"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="18611" checksum="33969F136219A5B1" modified="2013-03-06" version="1">MLTRSSAFLHKEFKRTKDNPSFSVGLVDGNIYTWEVIILGPSNTLYENGIFKAIMQFPENYPDSPPKFRFVSDMWHPNIDKDGNVCISILHEPGDDLYEYECVAERWMPVRNPESVILSIVALLNWPNSDSPANLDAAREFREDKALYDKRVLRLTQKTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZE7</accession>
    <name>L7JZE7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZE7"/>
    <dbReference type="STRING" id="72359.L7JZE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0613"/>
    <dbReference type="HOGENOM" id="CLU_545351_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZE7"/>
    <dbReference type="OMA" id="IFCRNLC"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="7">
        <location>
            <begin position="239"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="500" mass="57881" checksum="2198731FED79FDC6" modified="2013-03-06" version="1">MRTIGQITSKNGLCKDVTGSVHPLIKRKNNMRSALVTMEENRTASEQKGNEPDSITNENGKFENEKGVNEIHTTKRYKTGDQDGNATDKMEAKNEKKHAISNESTIKENDSHKKCNFCGKILRKIFVKCLKCEKKFHNSCSKKGSRIVEKYDISFICNDCNMCTECGLNNGESAVRCLVCPRIFHKACTTAQFCRPCREKLYMGAAHPEAMAKFEMNMFNSLVRSNGFMKEEKGQRYMNTEIIVNKLYIGNKKLSPRYLSPFINVSHVMYVCEKCFFYFKDSVSLERHRLKCDRYLRGNLVYSHGKLKLYEIDGEIDTIFCRNLCLVAKCFLDHKTLYYDVEPFLFYTLYDDDSNFIGYFSREKFSTKFNLSCIVVLPCYQGKGFGYFLIDFSYCLCRIYKRKGTPEKPLSDQGLAVYKKYWKYKVYNYLSRIKGSLSIEAISDELAMTHSDVVYALELLEFLKKADGKYYIEVTERLFVELKTCDPAGIITSNIRVFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZF3</accession>
    <name>L7JZF3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Variable surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993847">
        <property type="protein sequence ID" value="ELQ76431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0577"/>
    <dbReference type="HOGENOM" id="CLU_710154_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZF3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979279" description="Variable surface protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44057" checksum="5A64E951CCC67F33" modified="2013-03-06" version="1">MSLIFAFTILAIIERMNQMRIINTVKCGERKSLVDHDTQDKDSLTNYGNDDRHNKHSDAVTGIRPRKGKNGVIQNVGYDVVAGAASSSEVESCADSAAFESTSENLTGKSLDNESADTFGPDTCGCSSAEDTQSKLHADNENEEKKDDEEPIGFVNSLAGLTDLGYKTFIFYIKSGLNKIFAYETWMPAKNKQECVELFNNVYANISACREVLLKKFRDAVQYVLITSLQIIFILIRSVFKLIYVTEKRNGGDDGSGDDYFPKACTCKAYIEHEKLANAYYFPFRDKRRSLKLSFDHTIYDRFERNFDSERVNFLKYYLSIRDVIDGKVKHCEYHSKRNNNGKTCFNGNGAKRSLSGRTRMILVKTSILAVVMLFLVTLTVTVCYFWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZF4</accession>
    <name>L7JZF4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_0898</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZF4"/>
    <dbReference type="FunCoup" id="L7JZF4">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0898"/>
    <dbReference type="HOGENOM" id="CLU_041825_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZF4"/>
    <dbReference type="OMA" id="EKISCKH"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="49"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="247"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="345"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ76137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="504" mass="57039" checksum="D7DD42D94922B71C" modified="2013-03-06" version="1">MSCQQLLSFKNYKSTIEHKLMKFLSSITILFFLVIHCKLSDANTDNLLYTENQLKYLIADFKNALISSQKDPRERETFLDTFVRLPEASEKISCKHVLLAINLGGTYLQLGLYSIAKNELKLHSPVEKVLIPKADGSTKKVDCFEWIAKKTKLYLEKSNFKKSARAGITFSHPIKHESISVGRVLKLGKDFPFRAPNLGSENDAVKLVNAAFKKFKVPVKVDIILNDATATAASLIYGKNDEKAVTMGIVLGTGTNAAYIERQNRLTPTIINTEWASFDKGSVHRCEYDEAIEKMVKEQNKVYKRMDALIGGNYFMQLILQMAQKNIKDYISSENHAQGTFMMRNETEKSEKGNKKESENVAHVAKVDTKHDDVETTNRKKSDTNIKLDRETSSNSSKTNEFNTKAIDNDAQAPKSSVEDDKKAKESQTTNPSTSKIPNDVLVDIKYALNLVKNPNKNLTEQEKFILKCYKRLKRRSAQILMSMMIAIVESQPPTCQPRRLTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZH5</accession>
    <name>L7JZH5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-tubulin folding cofactor C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993811">
        <property type="protein sequence ID" value="ELQ76834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0157"/>
    <dbReference type="HOGENOM" id="CLU_1161901_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZH5"/>
    <dbReference type="OMA" id="RINNCKR"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="100"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="241" mass="27818" checksum="F89D9BD2F208EE34" modified="2013-03-06" version="1">MEHENKCNTKQHKDTSNREVKSQIIILTNKLRKEKVKYRQNVLQEQIKKLKELYVQNDEYDTPVVCDVAKLDIYNSDEIDHSGNGQIVQNGGNYSGVKDPACLNDKIVFLDENNVRNFRQNEKYSKVCITNMHKGQILAFDCDELTLKSCNNLNITANVSDSIFIEDVRDSTLKINAGQIRLLNCGNMRLVVYTKSGISIEKSEQIIIEEWKIQNMRHKNLFMKVNDFSDPFGSKNYTVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZK2</accession>
    <name>L7JZK2_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0508</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZK2"/>
    <dbReference type="STRING" id="72359.L7JZK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0508"/>
    <dbReference type="HOGENOM" id="CLU_326028_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZK2"/>
    <dbReference type="OMA" id="HCIAMNE"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="629"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="919" mass="105623" checksum="E2BF3675823556EF" modified="2013-03-06" version="1">MNIFNLSKEIINSPILNKMVKDPSFNKITKMEHNKIENTSCLFEKIRNDYQQKKKNKSYIQSTLFSEGIQQLLMSIISDNRDREDEEDSNVDNFEFCSFDHFKRQFRGENEKECDFFGSLSFEKSVVLEGAGVVDEIGDEGSFERSVVLHGDERRASLGGQGVSGGLGVSGSQGVSLGSRERSLGGQGVPGGQGMFLTRDERRISSNERRRSSDEQTTICMTNNERILGTRNDQQSFRTGSEQNDVNYGEDESRENGRIADDDKHYKNILDHKQWISNDLNRWQSKGCFTYTVQPAPPNNPFNRRINDQNTTNGSISADQSFSDKNIKQSKNVHERINTMQHSPSSCRRVVSVRLKRTLREEDGSVKVYKNKKMRLSAVRKAAADEHADECVFGDERRSTGRRVLKVVSARSLKIKLKVSDGGRKTVFGGECLGPADTCGEKRTLRNKLFNLRREELFLNRKLTVNSSQNNDVLSKHEQANGSLRKFTFGKDHGRGIFSTFDQLQGREAILSEFKKQNSTAILSGFNKEDRVGRGPVVHNEFNTRPRVFKKQGIFLKESRPKRRKSLKINIKRDRKKYQIEFKDDSSILSSNDKCPDENVPCRVEKMLSEAELVNILAPKTRYFSAMNFKGVKKIAEASFSDVYRFKDKIYKIIPFTEYYTKEEFLREVYVLRTLQNEKYVIKLRNFFVCKGAYNQHLHAAWDAYARDHKSENKRPNSDGKNGEYGCLVMDDAGTDLENYQFKKMSDILLFLKIIIECLSVLEFKYQFEHRDLHWGNILIQHNNMRNDSLCAFSENVRNSNLSGHFVPEDSAPFKVSIIDFGLSRFSTDHGVVYKDLSPEKELFQGTGDEQYDVYRQMKRICCNDWSKFNPITNVLWLKYLVGKLRHKGLSEKMCNMVMRMVVSSGSATELAQQMQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZL6</accession>
    <name>L7JZL6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small Conductance Mechanosensitive Ion Channel (MscS) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0524"/>
    <dbReference type="HOGENOM" id="CLU_036839_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZL6"/>
    <dbReference type="OMA" id="NMMLLRI"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
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            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="7">
        <location>
            <begin position="384"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="548" mass="63647" checksum="31C8C47FD90E8CD2" modified="2013-03-06" version="1">MNLKEQRVKRVREILSEDSERKTGKILSRKPVNIAWIVLSVILMIVSFAMAVGAYMSKKVLDKNADFYNVWWHACLVLFFFFMVNATLLMIARVVDPTGKGESFLAYMLDQNMMLLRITLSIGLYLVMLTLTTSLQNIFSPMPVITAPNSEPIVVPKDPSDTAGSKPESKQQKINKVKLQDYIERKYENIVFALLIVFSTLLAKRIFLQYINHRIHYKYYKDRIRENKMIVEYLQSINNITGTELDEDETDWSNVIFDSMCIGKEVLTLDDFRKFFGTSNGTKIFGLFDIDENNEVTRDEFTKRYNSLFMEKKQLDLALVQNSYNLYKFDCLLSAIIVPAVLFSTFIVLGAQSEFQNFFKSIGALLLSLSFAFSKLASDTFQSLIFVFFIRPFDIGDIIEIGGKTYVVSDLGLLYSTLLSDSRYETFPNELLRNSSIKNLRKSTHVTAKFEYCFKYDDYSKLDKLKEMISSFLLENPTKYHEQFDINHFEILNENKMKFTIQIVLSCPYQETRTIVERKDKFAIFVHECVKKLGFTYVELKPENKPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZR6</accession>
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    </protein>
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    </gene>
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        <name type="scientific">Trachipleistophora hominis</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2998124_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZR6"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ELQ76958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="57" mass="6602" checksum="CA62EF6E7226861D" modified="2013-03-06" version="1">MFFYAHDSTEHILRSNKINISIYGAINVHVYNNACDGVLKTSAKECLYVHDKHRNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZS6</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
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    <dbReference type="OrthoDB" id="2967263at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="103" mass="12030" checksum="20A22A7F02198B9B" modified="2013-03-06" version="1" fragment="single">VNVPKTRRTYCKKCACYQEKKQSLAKKGKENPRRQGARRYKRKQKGCHGQTKPILRRKAKITKKLVLKLECTKCKQVELKVCRRAKHVEFGGEKKVKGEALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZS7</accession>
    <name>L7JZS7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0061</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0061"/>
    <dbReference type="HOGENOM" id="CLU_3144005_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZS7"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5834" checksum="66D04FACA1B6670E" modified="2013-03-06" version="1">MHITIPGMASESVRDLYYLKLDLRRRPPHMSTLTNRSADAEDFHRHKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZT5</accession>
    <name>L7JZT5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0174"/>
    <dbReference type="HOGENOM" id="CLU_3224892_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZT5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="44" mass="4588" checksum="86C89DE3683E148E" modified="2013-03-06" version="1">MNGVVCGESSVDRKGADIRGDTTSIKVIKKGNGYCASAEDDDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZV8</accession>
    <name>L7JZV8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0001"/>
    <dbReference type="HOGENOM" id="CLU_2185770_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZV8"/>
    <dbReference type="OMA" id="IKLCCIS"/>
    <dbReference type="OrthoDB" id="10331048at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="12871" checksum="50B692E69067F8A1" modified="2013-03-06" version="1">MAERTSTFRSKHEALLKQFYITPSSQNVLALYQNAIDSKDDEIVEEFIKLCCISVDRTKFETCLTKIIERFVWLGLKYYDEMVGYEKARTLVEKEMERLKNVIKISNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZV9</accession>
    <name>L7JZV9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0025"/>
    <dbReference type="HOGENOM" id="CLU_012976_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZV9"/>
    <dbReference type="OMA" id="PRWERIE"/>
    <dbReference type="OrthoDB" id="10482676at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="801" mass="92140" checksum="1DA878CD11D2C229" modified="2013-03-06" version="1" fragment="single">VSMLPNLYSYIESVVRYIILFETNPEVHHDNYIIVDDLNDTGMVGLLEALLKKQKFYSFRYRSEKFDFKKNSHTKKDAKNLSLHYINRYFGVRREQYRHYYELLENDRNDTYKVIHVPFKRPLFQKIVKLSKDNIPDFTVEEVCVIFKYILPYKDRLPLITYAICIFLQENPSLADELNEARKDITRCGDNTHLKSLYSFIFGQNDTAIIFRDAVSSNIALTLRDIYANKAYSYKNPVGEYLFHLELDLEKLSIGFLFNRLYMDVVFLTNNMRLLQEKFQVNAANSSLDIEIHYVDDKTHEQEVTMVSGDQLSLLELNFISNCAFLQHNSINDVIVEFVGLNQEIDAEIFNESNVIRKIVCKFCSVEFVKSLPKHVTILRADFKETTYGDTKDSFVNITDVTYTESNFYEDIVPSDASKIRSISKSIFFSGSSISIDDTCPDITIQNTAATIKVCGLSMVAEVVLTESLFSCFKLMNKHDDYRLIEINEAVIQGAAEISVSMQIIALINVKLSSESKIVFGKGHTYITISESTGLFDLKCYIGIELCFNKDMLMMISPKGDSNQQLSQLILCGVKFVEKIHMPNRYERIEFKGITTAKDSAIILGDKCKELSIVEFNGVIDMRHVINFDSVTIHASMNEEASIKFIGLSRVSHLFYHNLYYNVNVCQLLAENFYEIEHLQFDTNCPFRDCEDIEKYHMYTGLRFIRVGNQRYSPYQLTKYLSKQDKADCAAISSLLDSAANFILNIILKQSANSTIKKLELLSAAVSCENYKLFKAQKGLEILKFALKILQVVFFILCPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZY4</accession>
    <name>L7JZY4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycogen synthase kinase-3</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
            <ecNumber evidence="12">2.7.11.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="EC" id="2.7.11.26" evidence="12"/>
    <dbReference type="EMBL" id="JH993807">
        <property type="protein sequence ID" value="ELQ76880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZY4"/>
    <dbReference type="STRING" id="72359.L7JZY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0121"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="InParanoid" id="L7JZY4"/>
    <dbReference type="OMA" id="QHLAMEC"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="324" mass="38512" checksum="D77A59C29B16AF70" modified="2013-03-06" version="1">MISLFQDKLNNAITKINDLMLVDQSIETNLRTLFFKYVEKIGKGTFGFVVKIEENNTGNVFALKTVYEDNKHYYREKEILENLKSKHFVRLYEYAYFEESTEGRYVQLVLEYIPFSLRNLIISDRFDFLKKFYEGKENFVDEMVKDFMKQGFEGLCYLHSFNIAHRDIKPANILIDYDGKLKFCDLGSAKKLENKNNTTYICSRYYRSPENIIGLKNYTTKIDIWSFSLSIAEIITRKVIFKGQSNVNQLEKILNLLKISQKDLLTMKLRRSKRETMGIKKYMKKYTSNKKLVEVFDKTIKFNFKKRRSAKQVLEMELFKKTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7K051</accession>
    <name>L7K051_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ77000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K051"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0027"/>
    <dbReference type="HOGENOM" id="CLU_2741833_0_0_1"/>
    <dbReference type="InParanoid" id="L7K051"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ77000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8313" checksum="847324DF340159F3" modified="2013-03-06" version="1">MEKKNNDMELSLEKALEKRSKSSLYFSLRTADVNLCKTRVEELDSIIDKLTSKIEILEKKIEKMNLKLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7K065</accession>
    <name>L7K065_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TRNase Z</fullName>
            <ecNumber evidence="1">3.1.26.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
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    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:damaged DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:interstrand cross-link repair"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ELQ76726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="360" mass="42533" checksum="933F296C4B5ABC73" modified="2013-03-06" version="1">MLQPFKIFSMRNPENANCTLLKHVPFHRRVPNTTFIVDYYKMLVSDVENTFLTHFHSDHYYGLKRSFNKNIFCSTTTANLVKLNIKVDVKYINEMEMNTVYRVDNVDIMCFEANHCPGAVGFIFCVQNVYYLHTGDFRFNVEMHANLQSLISIVRPGNNVNYFDTVFYDNTYEDYMHFDSQDDVIFNVITDIFSRNISMNTLAPIQTKYVFPSYSVGKEKLFLSVAYFFNWKVKTTEKKIMNIECYSAYTRRQINKSVVDCCERIRERLRSSSRIYPVFTKTSVQITKDCKDEPLSYVKTDLDDAVIEVIPFNYVNRVKLNELYGKTKFQRIVVICGTGWKREKRCFNLTKKIEKWLKKV</sequence>
</entry>
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        </submittedName>
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        <name evidence="1" type="ORF">THOM_0270</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
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                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ELQ76736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="14139" checksum="511A593AE63076FE" modified="2013-03-06" version="1">MSIIAKTKADLNTQILQNENHIKVVSHGRKYFAHYSSLFNELEYRVSKLAKFVIYEESELDGLQFYYDNCLIKVDCGIGNTEIVDYELTRDQFVEIIKVVYMAAVNGRKVVFMNELRNINF</sequence>
</entry>
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    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ76836.1"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="L7K0A4"/>
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    <dbReference type="OrthoDB" id="10634176at2759"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="57"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="212" mass="23471" checksum="CAC7FC1EDEFA681B" modified="2013-03-06" version="1">MQQTNVKLFVSPKTIKLENRRLFMNKLHLMILSLIAVVSAKRLARLNNSNLITAQRLTSEKSNDKKKKKKSGDDEEEEGDKKSKLMANSFMNTHSLLASQSGLAPSSDKSGGDDDQSGSKKSGSGKEQSAKKGKTGDKKKKDASENDEEEKKDEKKDEKKDEKKEKGSSLKAHNTFNSEALLKRRVSLLSDEIEPRDNLSAGAGNDEEDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR29</accession>
    <name>L7JR29_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3168</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="122" mass="13415" checksum="F66739FB47235EEE" modified="2013-03-06" version="1">MSEHPEASKHDDEEEQQQSSGTSFLKVILVLLFIVAGIAVVGIVGYVIYNAYFSEAKKGGTELRDAGGFKAESNFAPNDDKPKDEEEGSKKKKKDKSTSLREGLDMRNSQMIMANKEVPMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRA7</accession>
    <name>L7JRA7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3289</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
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            <authorList>
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                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994105">
        <property type="protein sequence ID" value="ELQ73810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3289"/>
    <dbReference type="HOGENOM" id="CLU_774307_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRA7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978631" evidence="2">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="358" mass="40428" checksum="06FC03A61AAC784A" modified="2013-03-06" version="1">MRLFTYNITIVLCYVQNAFGAYSENTRPVVKKAYPPLRYTNPTNTQVTPPPASTPMKEPEVNASPSDSDSFSLVRSLRYLHSTSGDDNSSTNRPRYYKNVGSWKKTICTTGSDKEKDSEERPKNSETYNPKKHLSTKKVRFSDGLKKNEDNIERSQYFLTFRSPNLSAQGTNKRADVINVPSLGTSSSSEIANAATKDSYNRFLSDNNNKLKEGNSVSKDLYSKNQYSTTPKKDKPVERVADMKTQLDDLMKKILTKKDFISVTDFSTLLNCHSAIQECVESAMPFLALYVEDILEDDNILSCIEELVESLSNLLAMEVSADSSLPSEFCYKLITLKENSSSRRDIIRKQWHVSRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRG1</accession>
    <name>L7JRG1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-aminoacyl-tRNA deacylase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gly-tRNA(Ala) deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_3010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRG1"/>
    <dbReference type="FunCoup" id="L7JRG1">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3010"/>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_1"/>
    <dbReference type="InParanoid" id="L7JRG1"/>
    <dbReference type="OMA" id="HHHIMLI"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF1">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="145" mass="16545" checksum="F71AB43F6E508025" modified="2013-03-06" version="1">MQLIIQKVKRAQVTVNNTPLSSISEGLLIYVGFHRTDTPAMIHQAVQKIKSLRLFNDTPLADHHHIMLISNVTLYARMKGNKLDYHMMMEYADAKRMFECMVGEMRKVHGVVETGQFGSKSVVECAVDGPFNFLYEIGGRMKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRH1</accession>
    <name>L7JRH1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3020"/>
    <dbReference type="HOGENOM" id="CLU_1662043_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRH1"/>
    <dbReference type="OMA" id="IMVNICQ"/>
    <dbReference type="OrthoDB" id="10287437at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="159" mass="18256" checksum="BB21FD883BB20968" modified="2013-03-06" version="1">MTIEIVKIAKERNIPLSPLLTSLAINNHSPSDPLSIVSLACKIHNIPCIFSLPPNHTEKQILEALEYNVNIPDTAQIMVNICQTINLSDNEMLYYLEKLLMVHLDERINVFNYFGKGYDTFKVCLALLKEEDLVFYEIISVENRSSDIDIIREKLRVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRR3</accession>
    <name>L7JRR3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994072">
        <property type="protein sequence ID" value="ELQ74124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRR3"/>
    <dbReference type="FunCoup" id="L7JRR3">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JRR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2952"/>
    <dbReference type="HOGENOM" id="CLU_103610_0_1_1"/>
    <dbReference type="InParanoid" id="L7JRR3"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="161" mass="19082" checksum="67EBDDEB0D20DDA7" modified="2013-03-06" version="1">MTSSKGYRRQTRKRFSQPFRKHGMPSISTYLTTYKRGDYVDIKVNPAVHKGMPHKYYHGLTGKVAVVHKNSLTVRCTRRFGNKRIHRMIVCRVEHLRKSKCDEEFNERRKRNDELRKQAEQENRMVGCLKRVQKGPREAFFIGLDGNEPVELRNEPFVNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS06</accession>
    <name>L7JS06_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zinc finger, C2H2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994056">
        <property type="protein sequence ID" value="ELQ74248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2825"/>
    <dbReference type="HOGENOM" id="CLU_460756_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS06"/>
    <dbReference type="OMA" id="YSLKCPV"/>
    <dbReference type="OrthoDB" id="2188337at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031514">
        <property type="entry name" value="Zf-C2H2_aberr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17017">
        <property type="entry name" value="zf-C2H2_aberr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="631" mass="74186" checksum="1F2E963D375D5309" modified="2013-03-06" version="1">MKNRKNVCRRKKINLVYKCLHNSCDLFYDSVLGLRRHISHYDHNLYYNPGYSLKCPVRKCSVSIVKLDNVEFLYDHFEKEHAQRLAAQLRDILVRIKKTYETTKINYLEHNVSDNCVNLSAVMRENDLLKDVLCSVYPSGVIKINDIDKPDLIFCGIPGCGKHFKSVMAYKYHCQTYLHSFATLFDSYCRSRNLDLDYERVKDLLCRKFSIADKFYLEGVTHHSIFSPDQFYTFTFSMDRELYIRKKRHRRNDMNVLEYNNLLEEDISVTDFSDQIDSLPSKIYYRGTKYDVFESFEDKNFKFVNFRSEITAAERYKDYFCVTYRSFNRKESKMFEFYREECRITFFCKRNQVGEFKHSYGFIRKIKFIDVKESFFYLALFNDGFLRYCKNDQVLIKYQQEKVTNFIVLGNFNTDTIVATDGFYLYKFEGPNIIATSTKFEFPIIAIEARITPTKELYLLNANGKVTYCDIDFRDEQEILTHAGITNIIYLKDIDGLLVCDSFMGTTKLVYPGDQKKKTCSLDSNFVCCSENTKKLIVSGTYDGVVTTNSITKKKKICSEKIFEIIRRKEYYVICSEEYELSICKNKPESDFDGAVRIINTFLIDNFMVIAIMSGFVVLLDLKTVKGDKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS10</accession>
    <name>L7JS10_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase, Non LTR Retrotransposon</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS10"/>
    <dbReference type="STRING" id="72359.L7JS10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2981"/>
    <dbReference type="HOGENOM" id="CLU_2203405_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS10"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="12242" checksum="2E882FED90368FBB" modified="2013-03-06" version="1" fragment="single">VERICSCSGSKRGGLDFLDNYRGISLISTLCKIVTKICANRLSNFSEREKILIHKQAGFRKLEECIAHATSLYEIGRQRSLKGRATYAAFLDFSKVYDRVPTKVRLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS18</accession>
    <name>L7JS18_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome biogenesis protein BMS1/TSR1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS18"/>
    <dbReference type="STRING" id="72359.L7JS18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3216"/>
    <dbReference type="HOGENOM" id="CLU_491063_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS18"/>
    <dbReference type="OMA" id="SADIMCY"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="1">
        <location>
            <begin position="253"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="555" mass="62396" checksum="D74E54685845CF13" modified="2013-03-06" version="1">MPSHKKAHLQKLKLVQKTNASEQHKYAQPTGAYKPLLILTQSSLRSGITYQCKTRYKIMNACDYPAHIVRMLSKVCVTVSFDMGVSADIMCYEGTRHARRQKVRGTWCHVDDLYKCARFVKRRAENVPVIVVDGGREDIYEGVIDYEMVSDEVMVNGMDRCKVIGLEYLDEAGAVIGCYTNGVGTNEQIKCVDTENNVTGALIEGNAINSTGCDGIDCNTPGSTCQCHKNVSYPDENVENNADHGFAMEECSSEDTQPSHITPLMESFKGYRGIKDLKTCTIHTGYSFKPPKACKLKKCDRLVRVRLSKRFDGDVFFISNVVVDDTPCILNVRFNERMDGGLENDNRNCGCAGINTANTMKYDKEDMCMKSCIDKMSVVSNEHVDTITSANVRCNGAHHAYTLEYGMFLHKVTPYFTMNTSSSVFKLQDESLKSGVVSFKVPYTPTNTPVKLFHAQKLVLSSNTYDHKERVIVEERVISGKPYKAYGTWCKIKNMFVCRDDVLFFRHVKLIGRGGNVGWIRSSVGVKGVFKAEFERPVKQGDEVRMCLYRLVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS73</accession>
    <name>L7JS73_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994070">
        <property type="protein sequence ID" value="ELQ74135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2941"/>
    <dbReference type="HOGENOM" id="CLU_3392563_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS73"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="32" mass="3509" checksum="44D3DCDEAF0F5324" modified="2013-03-06" version="1">MANIKGMGVSDNYKANKIIVAAEDERKTKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSC4</accession>
    <name>L7JSC4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2680"/>
    <dbReference type="HOGENOM" id="CLU_1723709_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSC4"/>
    <dbReference type="OMA" id="YFAANIY"/>
    <dbReference type="OrthoDB" id="2188762at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="17711" checksum="157118B967CFD6D4" modified="2013-03-06" version="1">MSGSASFKITYNKVLFIVVCIIDSIFLYATYSRDLLFWYIIIPVSIPILVFFKYYHFLVCYKTINRKNVNYALMSIGVSLLYKLCFFGLVFIAGRMFTMLIMGAIGFVDFVVNMYFAANIYFMKSLLYFDVNIPVDGYGIDEKVNQFGNAIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSF3</accession>
    <name>L7JSF3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase III transcription factor TFIIIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSF3"/>
    <dbReference type="STRING" id="72359.L7JSF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2646"/>
    <dbReference type="HOGENOM" id="CLU_020328_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSF3"/>
    <dbReference type="OMA" id="FRTAYNN"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="720" mass="85644" checksum="FA75195AD17F704A" modified="2013-03-06" version="1">MDDMFRKTKFKKSSPTFFYNKRVGHLLTEANECFVQNNFEKAIKKLKRAIRIAPTCHQAYYLLGLMHEENSEFSEAYELFKICYNIKKKDTNLLNKLYDYSKLLDKKEDTLLFIEKMGNDELYEEQLSLCRYLNQEERAHEAIINHEQDFTLEFLKSLSPKNLRKAVFKSLDRIVDEYTAGYTEELCDENLTRAGNEKFDYIIDTLYKNSSYDAVYQIYEKCGGVFLSTKNKLIFAISRIKSNNYTSLDILDKKEVLEYDDRYRDLFFELGDLKNEVLEFLSENGTIDAKKEALKRLADKSERCESRHTEGHKCNLFYYLKYFDLDPDDNHVRMLIYSIYKEQGNNEEAYKYIEMRTTSYSYETMVQFFKSVNDKKVIRYTSKECNEIRRIYNETLQLRKKLEKFNETDLVSFIKVNSLLLHDFFNNLFIFNPNCHRLNSFFTRSDKPADFDEVIYQSLHGLDVHEWYEVVKGNFLCTIGNGTEEPFDLLYKSLEASIFKNTSFYFNIIFILIKFSTLLGNIKFLTRAVKKFYAKNRTVFNLYHFLLNFFVDYCNSKSFRTAYNNLRRIHLRHVDKNIKQNDDFTFLLSNLPFFLYTETLDKIDQVYGNSELSDTNTVLLAIIYFNNSKSRRISNRNYYIEKGFSLLKRALERDGSEKDLIMYNLGRAYHHFGLHGLAETCYKKCMATKFKKLAAFNLILIYRSSQSKDLLRHFILNLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-05-03" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSJ5</accession>
    <name>L7JSJ5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994085">
        <property type="protein sequence ID" value="ELQ74021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3065"/>
    <dbReference type="HOGENOM" id="CLU_155630_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSJ5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="142" mass="16775" checksum="ECAF18F571DBAC22" modified="2013-03-06" version="1" fragment="single">VFIAELEYNYIDSKGVDVTSTTFDMSENYYELLFFMSYNLFNTIRFSSKHSIYCWDIITTLECLNDKTIATKIFIHRFDCIKKYYKESVKDLYSYIENNQSVEGLPDMDDILRRLEELNGDVEKIMLGLSSIYKMIHEGFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSK9</accession>
    <name>L7JSK9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994083">
        <property type="protein sequence ID" value="ELQ74036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3064"/>
    <dbReference type="HOGENOM" id="CLU_004199_2_0_1"/>
    <dbReference type="InParanoid" id="L7JSK9"/>
    <dbReference type="OMA" id="MIINLKM"/>
    <dbReference type="OrthoDB" id="10495017at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1393" mass="160321" checksum="12A2EDEA9D15256F" modified="2013-03-06" version="1">MNLSFVKTSTMLVRWILLFEREAEDDESNFLIFKDLYEAQLKNFYEGISEICLLQIPIFKMKEYNALVDPLNIIKPSGLCEDVDIVREKSAEKDNNDHVARYMTMKIPVTKSIFLKAINASLENKITLSDSEIYDILDHLILFLDNKIILRRVICQQLLNDGDLYNRLKICSMERSGSNQQKNLRFEMAYKNLIAEMQNEMYVVVKDEYSNFAFVSSIDGTKSEPPLYANTLSILYHFPKCILKTTSTFIFRNRKLLYKTYNEVPFHELHIVIDIDFSDIACHILHRSDHMISLSDSFKSKIRKILKCKFLTFQHVKKVILRFARMRLNFDLSFLSNPELELYIEDCVLKKGFILPKRLKKLTICDSSLSISMILPITLENISMKRSQIKTNNTLNVNIGCIVVDIEHCSGHVCVPQIEKMLNIQFGEVWSIKITLKNDECVDILKVVNGTFKNTMINISQEVKTLILKEVKFLPETQLIVRSHIESIILTRFTGTVHFHSLISNAIISITITNGSMILSKSKQNYGMLKFMLHSAIVMSTNEFNERVSKLDMKNVNIMNNNYIKIHKNTRNISLENISGQFLLDNIYGFQRIDLASDGYFYLRTLDQHQTFSVLSCLYRGNELVLENTRINNSIFLGPSIKRLKLKNIVIAENCSLRIDNDIEGLKIKDCTGKFKIPFISHEHELMINFTQSEYSLEITKTSVNAYSITAINMIIEISIFINVNISDLNLQNVLIKENAVLSLNYTCINVSLNNLKGRLNIRNSTALDTLVLHNMDFTENASILAIPINRFEACNLLLSHHVIIPCVPTQFKHHESIYSSMENILRGIPLNNLKNFLLNHNRTSINLIHVLRNVGSSESRFLVNGFVKLFNEDGLENCTKLKLKNFQILNHVEIVKDVKILHLSHVRSANGSTLRLNKEVECLRMKCTTVDIDITRAIHLKSITIWSSLFIYDCKAYQSLTYLYLSKLEIGQNVCIGNTLQTLKLHNVVIKRSCMFKIGKNVSYLSIEKSSGVMHMSGVGGLRFLVLNEKNTIRYRRALRTPKKYAWYFADFCFEGDIQFSNDSAEIVLERCEIAEGVKLLFGEGCKSVKLDVNRIDLNGYNAVNLEKITLTNVLPHILNKAFMLGSLNTLTIQNFKVTNVIKCADHIRTVILQMVDVVKKRTFHIGENCEEIHFIYCTGVFNLATVRNLKKLVIIPQIHGKLFFKNSLHFLHSVLDLEMAYNFESSFLQAVLVNCISVVRLTLHSLKYRKSIQMDIFAFISFKNILNISCSDHWLKEKFPQFNLARPSLLNADRAMIINLKMNALFNELITFEIRNRLQHLNLVGFSISKKNGEQLKLFQNLKTLIVDYYFIDENFFSFLPSTLEALEIVETNIFFGANCTDKNANFALKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSN9</accession>
    <name>L7JSN9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small Nuclear ribonucleoprotein splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSN9"/>
    <dbReference type="STRING" id="72359.L7JSN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2588"/>
    <dbReference type="HOGENOM" id="CLU_197704_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSN9"/>
    <dbReference type="OMA" id="DWEYSNT"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="71" mass="8032" checksum="262501C0776256B2" modified="2013-03-06" version="1">MATNLKKFLIEDLNEYIDRTIIVKLIGGREVKGLLKSYDNNFNLVLKGGADWEYNNTLFCFGASVVSICIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSQ7</accession>
    <name>L7JSQ7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994037">
        <property type="protein sequence ID" value="ELQ74513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2557"/>
    <dbReference type="HOGENOM" id="CLU_3052059_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSQ7"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="54" mass="6317" checksum="A395969A9B37F671" modified="2013-03-06" version="1">MVQSIQEIENGCLVNANSELHYFVVDQFLSPDHVTIQRIVREIKKLEKEQDFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSS6</accession>
    <name>L7JSS6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994107">
        <property type="protein sequence ID" value="ELQ73792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3294"/>
    <dbReference type="HOGENOM" id="CLU_3282356_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSS6"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="41" mass="4917" checksum="2FC710AF672C6BBE" modified="2013-03-06" version="1" fragment="single">VSVRVYSGNMVGILFFGRAVKLRFKCFLVKRVVERNRRTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSU4</accession>
    <name>L7JSU4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Reverse transcriptase, LTR Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2729380_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSU4"/>
    <dbReference type="OrthoDB" id="5152741at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="72" mass="8444" checksum="98DE98857CA181AF" modified="2013-03-06" version="1" fragment="single">VIFQRVINQVLDRLIGNGLESYMDDIIIHFKKYDALVREVIKRLSRNKLKVNMKKVEYARQEVKLLGVTING</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSW4</accession>
    <name>L7JSW4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994102">
        <property type="protein sequence ID" value="ELQ73832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3272"/>
    <dbReference type="HOGENOM" id="CLU_3415269_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSW4"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="27" mass="3351" checksum="D4D7740089D57EE3" modified="2013-03-06" version="1">MMVEERMMMERCRNDLRIITVNKVHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSX4</accession>
    <name>L7JSX4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3217"/>
    <dbReference type="HOGENOM" id="CLU_2984815_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSX4"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="58" mass="7032" checksum="56D658C71EE24995" modified="2013-03-06" version="1" fragment="single">VHHRYCKKEELNSDEKKFMLSVKHKFKNIPEEFKFKHNGLTLDEVWHNMVNSTSKKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT52</accession>
    <name>L7JT52_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3133"/>
    <dbReference type="HOGENOM" id="CLU_3130054_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT52"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="5815" checksum="329B35F3026671AD" modified="2013-03-06" version="1" fragment="single">VLTDERFYTFLASVLRYNNPIGNKNLYSTTLTGGIMVFNENDIRDLNLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTA2</accession>
    <name>L7JTA2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA polymerase III subunit C17</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTA2"/>
    <dbReference type="STRING" id="72359.L7JTA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2805"/>
    <dbReference type="HOGENOM" id="CLU_176428_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTA2"/>
    <dbReference type="OMA" id="EKTMAFA"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="108" mass="13010" checksum="C9B1CDCF9DD18423" modified="2013-03-06" version="1">MYQKKCIPKSQILHFMNNETMLTEEEKTMAFAVKELCKNCMPTDVIYKTRLKLKKMNLYPLEICQLLDMWPKNLLDLQMVIEDMEERFSVHELEGILDIFRQNEIQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTG2</accession>
    <name>L7JTG2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin complex component, TCP-1 epsilon subunit (CCT5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_3004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994079">
        <property type="protein sequence ID" value="ELQ74052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTG2"/>
    <dbReference type="FunCoup" id="L7JTG2">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3004"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="InParanoid" id="L7JTG2"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ74052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="447" mass="49345" checksum="58F2691BA87D8AFF" modified="2013-03-06" version="1" fragment="single">MVMTENPISRLLQRLSSAQDEEIGDGTTSVVLVASALLAKAEKLIEKGIHPIKVSEGYDVACKLAIEHLESIKEEIRPSSLKENMKNAALTSLNSKIVRKAKDAVAEVCVNAILKVCDKDRRDVDFELIKIVKKIGPDFKCIELVNGVLLDKSFSHSQMSKAVEDGRIALLTCPFEPPKLKTKNELRISSVEDYKNLENYEKEKFVEMIRCIKNAGANVILCQWGFDDEANSLLMEHGLPAVRWVGGQDLELAAVYTGGSIISRFEDLREEDLGRGSLKEITMGTQSEKMIKLENNDGNTVTILVRASSDLALAEAERCVTDALSAARNVLTCPFVVYGGGSSEIACSLKLQERLNKVDDGEERECLEAFCAALEEIPLILARNSGLDSLQTLDALKAEQLKTKFYFLGVDCTGNGNDMKKNKVFDSLVSKKKQMMMATQLVNMVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTH2</accession>
    <name>L7JTH2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2709"/>
    <dbReference type="HOGENOM" id="CLU_2251927_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTH2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="104" mass="11546" checksum="A9F484DF73D6C4B3" modified="2013-03-06" version="1">MPSLDTAFSENVTLHAGHETLHVHSSFLFRVVIGSGIRDRRCTSISFGMHVVFLCTVTRSIAIVGISLRRVRRIAFRNDGVDGVIVRLMVVGVVSRITIFFMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTJ1</accession>
    <name>L7JTJ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994045">
        <property type="protein sequence ID" value="ELQ74366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2729"/>
    <dbReference type="HOGENOM" id="CLU_1305649_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTJ1"/>
    <dbReference type="OMA" id="QSTHIEL"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979129" evidence="2">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="211" mass="23966" checksum="E11FCE06E8D57015" modified="2013-03-06" version="1">MWSTFFTLAFERLLSTQELTVYGENNNSSHNWDDVLTMIIRRLIQSGLNGADVENDNGKNSHVDNNDGNDTTMVTNDDHTNVESRKNSNDDESHNTSTNTFIDLYPYDTKQRGLKCKNFEWFNVRNNMHITTLVDSSAALNATSLRNCDEIVVVNTPVSTCNESSLQNSNEITSVKALKIAKNKYSSDEGTTKDCHQEYFTLSDFTLLYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTK8</accession>
    <name>L7JTK8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994043">
        <property type="protein sequence ID" value="ELQ74386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTK8"/>
    <dbReference type="STRING" id="72359.L7JTK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2684"/>
    <dbReference type="HOGENOM" id="CLU_088310_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTK8"/>
    <dbReference type="OMA" id="NPMVKNM"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="264" mass="30362" checksum="B44B5AF3F95FDB36" modified="2013-03-06" version="1">MQITITVQFQNNRMPLLMDIHETLLSLKEKISKRINTPASDISVYYNNRYLTDDKKTIKELKIENNAVVYLKKRRREIEPGQKSDATEQMLKNPMVKNMLKNPEVMKGMLESFPGLKKQINKNPELRMIMNNPNAIEEFEKLADNPEYMSQQLKNVDIAMSKLENIPGGFNMMNSMIKDVRDPLTGLITQSNGVSVCAGNQEVQRKVIPNVWKKKKGENFFVKYRREINEIRKYGFDNINDIANALGKCGGDIDGAIDVLFKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTL1</accession>
    <name>L7JTL1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994077">
        <property type="protein sequence ID" value="ELQ74097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2993"/>
    <dbReference type="HOGENOM" id="CLU_1826644_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTL1"/>
    <dbReference type="OMA" id="VRYGKMI"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="141" mass="16146" checksum="E1AC0DD1CFD6FDAB" modified="2013-03-06" version="1">MTKTPSLNDKLSKTFSSLKGTITSLNLHRNELLANKIKTEYFSDVRYGKMIKMMDECVVEMEKVVCDMKGMREKFALERGVLRSGNVQSKSADRSKTGDRRECTALVDKKGKINSATTRRKKRIVMRRKGGKLREQDPNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTL2</accession>
    <name>L7JTL2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994026">
        <property type="protein sequence ID" value="ELQ74744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2326"/>
    <dbReference type="HOGENOM" id="CLU_2851318_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTL2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="65" mass="7374" checksum="353E2CE03B398913" modified="2013-03-06" version="1">MCACNNTNDSIKYFVVEICISNTPTSIDEQQNCIYDCSSSNYTGSTTVKTSKALYNNEQYTHRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTP0</accession>
    <name>L7JTP0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA mismatch repair protein MutS, core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTP0"/>
    <dbReference type="STRING" id="72359.L7JTP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2655"/>
    <dbReference type="HOGENOM" id="CLU_698654_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTP0"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="395" mass="45947" checksum="85ADDD18B0D4161E" modified="2013-03-06" version="1">MRLNSNSDENVEIEIRNLIQNTEPSENNIDTSADIVSNMVPSEDSLSAKTDKTCIKLYLKNDTYRCTDVSVTKSHGKTFPKALGEQLIRELLSAYTVEEYIEKDGATVLNRRGSPGNWESFSDIMLGDMPVSKFGCIALNKNNVNFWFYDGIANVISKAMYLDDDIFSMTYTIISKENIREVIYTSKELERPLITMGIKATRVGGKDLNLVKYLNLTDVREKNYNNVNLNLDNNLYEELNLDEVAKLYNFKTTQGKRYFYTNIRAPSRDVNEILRRQKILFFFRRNNIGREFPDLLRIVKKVEREKISVNEIIVLCQILEKKDCLLNDVLNTAKKCAECDIDIVNEDIIVPLQTLDFTFATKEIREKIDFSLERVRCFNRYNERTEIKERRDMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU21</accession>
    <name>L7JU21_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60s ribosomal protein L15/L27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU21"/>
    <dbReference type="FunCoup" id="L7JU21">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2277"/>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="InParanoid" id="L7JU21"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="74"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="143" mass="16234" checksum="E6737A73DDAB6208" modified="2013-03-06" version="1">MFHKRTRTRKLRGHVSHGHGRVGKHRKHPGGRGKCGGLTHHKTLFQKYHPDYFGKRGIKIFHRKTQALRFNITNTGDLFALIRHNEFVEGQAPIIDCRAHGIHKVLGRGELSLKQPLIVIAKQFTEEAKRKIEAVGGRVIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU53</accession>
    <name>L7JU53_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_2235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU53"/>
    <dbReference type="FunCoup" id="L7JU53">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2235"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="L7JU53"/>
    <dbReference type="OMA" id="GIHHCHR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140836">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat S5 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905866">
        <property type="term" value="P:positive regulation of Atg1/ULK1 kinase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ74835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="328" mass="37309" checksum="3B4640D4BB8772BE" modified="2013-03-06" version="1" fragment="single">VFYTSPMLSYLRQKKLGEGTYAVVYLAQMVQSSGPHKIIKSIAANTHVSTVAIKKIKHYSSTTGIDLSTVREIKNMQRVQSKYVLTLFEVFFHNNSVNMALEYAPYNLEHIIKNRQLVIMPSDIKAIMLMVMKGVYAIHRKFIVHRDLKPNNILLDANGIVKIADFGLSRDLGDNMTSYVVTRWYRAPELLFGAKVYGFNVDMWSIGCIFAELFLRVPFFAGENDLNQLDVIFRALGTPTEHDWPGMCTLSNFVKLPSYPRVPPKTIFTGATDDAIELLEKMLVFEPQKRISSYNALKHAYFSGGDRPTLPKNLIMSLRTTTEHVDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU90</accession>
    <name>L7JU90_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2028"/>
    <dbReference type="HOGENOM" id="CLU_2575553_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU90"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="81" mass="9901" checksum="9D41A2AADE2FEF16" modified="2013-03-06" version="1">MKRLDDLIDMYQNFANSIRDDLKTKSKRAEYLIKHDRIHRLCDEFPGYFAYIMWLMLKEKRKDIKIIEAIAIHMRKKLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUD7</accession>
    <name>L7JUD7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase delta, regulatory subunit 55</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUD7"/>
    <dbReference type="STRING" id="72359.L7JUD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2014"/>
    <dbReference type="HOGENOM" id="CLU_021763_2_0_1"/>
    <dbReference type="InParanoid" id="L7JUD7"/>
    <dbReference type="OMA" id="ICFIADL"/>
    <dbReference type="OrthoDB" id="2190112at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="4">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="203"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="353" mass="40067" checksum="B07D00A74985E173" modified="2013-03-06" version="1">MRKDFLFQGQYNQTYVTRLEKMRSLINLDVHDDTTILSNLSEASSASGPVAFIALLYVDCANKETIFDEAGLIKKEKNVKPYENFTYFVEDESCRVEVIFEPKDLFVTGQVLGFIAERNTHSLTIKSVIYPVQLKLTGQLDHDIICFIADLRIRNSMSELNVITDYISNSKKVTDLVIIGDIFDEVTKENADLLAQFLEDFGADAFIIPNINDPTNKLLPQQPISNRIIDYNCLFLPSPALFEVGAKMLFIPPVVINDIKLYGEPSAINIMKMLVKIRHICPTAPDTVGCVPYNGEDPFILYEMPNYVFTLGDKFEKEMGEVSYFVLPSFSKSKQVILLTLDKRNFETVALEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUE5</accession>
    <name>L7JUE5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUE5"/>
    <dbReference type="FunCoup" id="L7JUE5">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2024"/>
    <dbReference type="HOGENOM" id="CLU_027593_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUE5"/>
    <dbReference type="OMA" id="LEECHTA"/>
    <dbReference type="OrthoDB" id="2193786at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09900">
        <property type="entry name" value="H3TH_XPG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF59">
        <property type="entry name" value="FI23547P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="3">
        <location>
            <begin position="524"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="728" mass="85206" checksum="6700E19C298CFDF2" modified="2013-03-06" version="1">MGVKGLWKLLEECHTADTPRNQRLAIDASIWLYKYKNVPQTNMIYSFVKRIIMLLYHKNSLFFVFDSKAPAEKIKTIAKRNEIRLRNELKAHFDKIANNRMCTACNVLYKTCEHGREVNMEEIKEIEDVVSYKLRNHDYNWGDDVSDIDDDTEISECNLTYGYNKGWSRTNTNCDELVNEEKEEFLPKNFDGLSQVKKLKVLDELREANAFQSCGFKEMNGKAFSEYQLKKIGRSYAITSLINEVSDTKNKRIMGDCRSYYELNYENDVPKRIKKEDKEAFDIFTLEKEVKQVESNKDSANNEIIDENRFVAEINSIFMENEGSVSVSNQNDASNNMDWDSKELLYQSNKRDSMAKNEIKTAQEVKNFSFQNIAEVARSITKEPEESKNVYLSVDKNSVFYKNECYGQSENRMEENNEGMMNQQVEIKANMRGAINFIAESKIKNSENNEKHVESLAVTNDELMTALEKNNEHDVVDPIQKMDKEMEERVRDRMASLERNIRTRSINLMNELQCITVLMKKMLTILGIPYIDAPYESDSQLGYLNNECELERNERKSVFNPEEKCEHLDTNQVFNDKIYNLKVDAIITEDNDVFLFGANRVYKDYFKCPKLYTMQNIRDKLNLNREDLIKLSVFLGNDYTVGFRGIGPKKALEILKDEDKANYDRKVFDSEYSKVKNVYYKSIVDKKPLKLRSSRKLSEIRKFLSDNFLNDNQINEIVFYLRKINAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUF7</accession>
    <name>L7JUF7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2134"/>
    <dbReference type="HOGENOM" id="CLU_1797805_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUF7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="144" mass="16449" checksum="4A47DE660CEA2BD9" modified="2013-03-06" version="1">MQCALLFYVTNSTVAWKELFEMDRNERSTGRKGVSPFGALFFEKKIILQWPLGSLQKELIRKRRRNPKKSGFMQRHHRDDPHPRDSQKASQSPRGDSHSGLHPRNRGSYSSPQTGNTPCPNYNKSILVHYLSGRSGLPGLCNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUI7</accession>
    <name>L7JUI7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994000">
        <property type="protein sequence ID" value="ELQ74980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2078"/>
    <dbReference type="HOGENOM" id="CLU_2529071_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUI7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="84" mass="10049" checksum="D3229C1482161B48" modified="2013-03-06" version="1">MEKLSIDEIINTKNIKSLLSRRIEEIQSYNIKNDIENMKSEIRDCKPFSAPDDESINENSEFLNELKDNYRFSYFENDIKNYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUL0</accession>
    <name>L7JUL0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">26S proteasome regulatory complex, subunit RPN11</fullName>
            <ecNumber evidence="8">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_2047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="8"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ75005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUL0"/>
    <dbReference type="FunCoup" id="L7JUL0">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JUL0"/>
    <dbReference type="MEROPS" id="M67.A10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2047"/>
    <dbReference type="HOGENOM" id="CLU_052991_0_1_1"/>
    <dbReference type="InParanoid" id="L7JUL0"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="54"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="329" mass="37438" checksum="D1A26E9DAC01E939" modified="2013-03-06" version="1">MNHRFILFYTLRQSSAKLITTAPTTQNKKNGRNPSMNFAMMDSLGKVPDTSEIIQISSLALLKMLKHGRAGIPMEVMGLMLGEFVDEFTIKVVDVFAMPQSGTGVTVEAVDPVFQTQMMDTLAVTGRNETVVGWYHSHPGFGCWLSNVDISTQSAFEQLNKRAVAVVIDPIQSVKGKVVLDAFRLIPNQMGLTMSEYREVTSNIGYYNSPSVIALLHGLNRSYYSFNIQYRKTEMEEKMLLNLHKKSWTDNLRIRGVRSEDMSTKMKELTVNYLKRVEEEKSLTKEELELYKMGKLDFRKHLMDTCEDVCNENTLHNLLVAIHSTILYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUP1</accession>
    <name>L7JUP1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2582"/>
    <dbReference type="HOGENOM" id="CLU_1662041_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUP1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="159" mass="18405" checksum="2B839CDA81F86318" modified="2013-03-06" version="1">MTKIDNFGLALQNACTCLCETLCIREERMATNLKKYEAENVSIIPQPSEHNGENNICIIGLPMNFSNAGEMMVLPINEVVNMFQNVARMYTDSIKYVLINKSPVYSFERNLKRCEKNINNSLRQALLSVNELHKIYLLYKQPLTMNEVNYVLFKKTWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUP2</accession>
    <name>L7JUP2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994025">
        <property type="protein sequence ID" value="ELQ74746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2307"/>
    <dbReference type="HOGENOM" id="CLU_1020095_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUP2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="273" mass="31075" checksum="759E6D513B8C78D0" modified="2013-03-06" version="1">MDATKHETSDKPKKRFLKRYWSVNAHENVDGNSARACNDSGVYRCEPDYRETVGRTRLSEGEMRGDGSAKELQKVVRSNLQDARQIAVEPGKIRRLSTNVDDNGECAALSSGVSRIRVRSVGDDERSNDQIGEETRVRHSDTKHGTEQSNDQIGKETRVRHSDTKECLRTDNKTTQHLNHKPTSTSQDMPTVSLNNPPLPTNETHSSERIDSTRTNIENASNWDTMKLYLRILIKFWNIDDHYIINQTGILAKAWAPNYEAVPPEKSGWKRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUV0</accession>
    <name>L7JUV0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993980">
        <property type="protein sequence ID" value="ELQ75243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1814"/>
    <dbReference type="HOGENOM" id="CLU_3362241_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUV0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4211" checksum="B565CFC56B89C5D8" modified="2013-03-06" version="1" fragment="single">VYRIKDTKLETHLSLHKLLSDGLIVLNIHKKMIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV00</accession>
    <name>L7JV00_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993986">
        <property type="protein sequence ID" value="ELQ75135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1920"/>
    <dbReference type="HOGENOM" id="CLU_585531_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV00"/>
    <dbReference type="OMA" id="YICASEM"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="467" mass="53516" checksum="331045847DF41C8C" modified="2013-03-06" version="1">MMLLLIFYIAEVLNNNNNGDLQSRCCNKDKKTLPVKQVSHNSDFELTEGRLNQFKPNAEEQLVESFKGLIDTVIAIQTQPNDTIAFANTVNHLLHLFCTNLITKLGKEMNENNYYNTNRKQVCRFKINLNCLFEIGTMACSIKQNILQYLKWSYIGYIMNVVTTFEGTFTVGKDDIEISGCHDLFHKTQKILQIITNWLVDSSHEYMIDQGYANTYDHRLYNGTNQRNFILPHKQGCPSVIKQQKSSLILIDSSKDEYAARQRCIEEQSIIIFAFDPQEKIVYICAGKVILVINTKKYEESRIQLIKESSRNIFNPADSTCNEDSMKIIDDLLRIPLVKPQSEKKNAELCCGIDSQSTTDNELSENLVAETENLQYDSDIDMCNTTLTGIEDDKTYYERLFSEMPALKNDDDVLKDGNISEASNASTMSDNDLNNNFWESDSAKDKFLKSHETQYDKLTFEVSVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV22</accession>
    <name>L7JV22_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993975">
        <property type="protein sequence ID" value="ELQ75259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1799"/>
    <dbReference type="HOGENOM" id="CLU_3299682_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV22"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="4287" checksum="3D919CF47B576C69" modified="2013-03-06" version="1">MSPGCLLTTSTNYESAKCTNVKCRLAAHATHSRDPSLAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV41</accession>
    <name>L7JV41_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative EF-hand-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1781"/>
    <dbReference type="HOGENOM" id="CLU_149442_1_0_1"/>
    <dbReference type="InParanoid" id="L7JV41"/>
    <dbReference type="OMA" id="EMITYFN"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="132" mass="15710" checksum="AA6A5A0DF502004B" modified="2013-03-06" version="1">MLRIQYQIFTISGHPSMSDKEIDEKFKLFDFGEKGYLTPEEYKAFCYSMLKRPKKIKSNQIHRNDIADICNEPKDYTGYFEFLSDNGKYITYDTMKKALAKLNITDDDIREMITYFNEQGVLSYNEFVKIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVA3</accession>
    <name>L7JVA3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_1656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVA3"/>
    <dbReference type="FunCoup" id="L7JVA3">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1656"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_1"/>
    <dbReference type="InParanoid" id="L7JVA3"/>
    <dbReference type="OMA" id="GPCHVLK"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ75359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="317" mass="34410" checksum="F1FBF73C117C15FF" modified="2013-03-06" version="1">MSECMVYDVIIIGSGPAAYSAALYLQDYKVLVLEGGIVGNNGPGGQLTTTTVVDNYPGYPNGITGPELMMIMKKQVESKNLCTKEETATALSVSSEGRFFNVCTRQGDYVAYSIVIATGAQAKRLCVPGTATFWQKGISTCAVCDGHLFLDEVVAVIGGGDSAMEESLYLAGIARKVYLIHRRDTFRSRKDMLMRVEKNKKIEIIRSSILVEAKGEKLLSSIVVKNVVNDELCELAVDGLFFAVGHLPNTDFIKKGFVEMDEGYIKTDSLMRTSRKGVFACGDVQDRIYRQANTAAASGCIAALSVREYLNGSNAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVD1</accession>
    <name>L7JVD1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Rho GTPase-activating protein domain, Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993977">
        <property type="protein sequence ID" value="ELQ75255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1803"/>
    <dbReference type="HOGENOM" id="CLU_610025_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVD1"/>
    <dbReference type="OMA" id="CEFHNKM"/>
    <dbReference type="OrthoDB" id="2196166at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="250"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="445" mass="51956" checksum="8B6ED3E82FE3B700" modified="2013-03-06" version="1">MLTMIEKNNSSNDCENGYERRSVKELVKFFNEKDNLHVHNFTIRDACRRTNLSTGHHHKEIEGRGCLEVRCDRGVNGSAACDDKQIENNEEKIGPEEETINKESVVKTYEQRTKATSDETAIALKGCKLSKLYEKNLNEMLIFSELKTTNVQHIKLTKKKKISVSNRKIVRCNTCSDSQNVKKEKRMCKKSVKRSTEKRVTVLDKDFIEYEKLCKFEKWRLAVYCMGNLRKMAIRENFFVKSFNFLLQLFKLHDFPRIKSDCVSPMIFSLINHLKMHGQREIGIFRLSGRLTNVQMVLNKIKAGQDVNLSTYPVRDIVSLLKIYVRNNLDGICTRNVTKILLNIFQRNTDTINKSLKYLPFIFYGDRRKLIISLFELFDEISSCEFHNKMSRQMLIRCTAPTFFSTVKVLDLSIVPTQIRVVETLSKLNFKYVPRDLYEKAMKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVE9</accession>
    <name>L7JVE9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Microtubule-associated protein essential for anaphase spindle elongation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVE9"/>
    <dbReference type="STRING" id="72359.L7JVE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1772"/>
    <dbReference type="HOGENOM" id="CLU_665957_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVE9"/>
    <dbReference type="OMA" id="NCADIEV"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="413" mass="49569" checksum="048FA53ED881F156" modified="2013-03-06" version="1">MEENIISRIHSNIDKLNNTIHKLSPIDELIVPSPNYLEEHFSNIAREIDTALERVQEKMREIENKLEKDKQELIVRGSRIGLSVKFEKFENLMLDRLNVANERNRIIVLEKIMMEKVKFFSKQINDYHYDLYGTYSGYANNECSLENLETVRKLHDKLVADVNLRFNQRRLLKKKLLKYKMKDIDDMKFFQMVALVKKITEQEEKEEKLKIVLRRSIHRVLDLLNRDNDVVLPNNLEKLKIIYEKLLEEEKAQFDRIFDATEREFNEICSIFFVKFDKLKRTRESIILMKKIINDLTERKEHFVELKELIEKRARIIVEIELFEKTARDPNRLKGSSLQLLHEERFRRKVIPSLLEMESRILGKLNDYKQLYNEPFMYGDEDYEEKLRNEINGRIIHSSVYVSNKAQSPWKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVF6</accession>
    <name>L7JVF6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2011"/>
    <dbReference type="HOGENOM" id="CLU_1590447_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVF6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="188" mass="22852" checksum="94524F1242183431" modified="2013-03-06" version="1">MRNLMDYLSSILVKWLLEIVMFGINGERRYMRPNYNEARREYRRMCKNKHTYNQNARRILGLGKVKIVNAKRDKIKQLRYYIWSRKRSKHDRTIYEDENVSEKRKRKSACASDNVVLMRVFHKKLVEMINCGNLMIGKANKKLLMMLFSIQLLIDYYKVGSLKMIVYHNRWKIELKRTERCYEIEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVN1</accession>
    <name>L7JVN1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA excision repair protein XPA/XPAC/RAD14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_1657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993966">
        <property type="protein sequence ID" value="ELQ75360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVN1"/>
    <dbReference type="FunCoup" id="L7JVN1">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1657"/>
    <dbReference type="HOGENOM" id="CLU_053731_2_0_1"/>
    <dbReference type="InParanoid" id="L7JVN1"/>
    <dbReference type="OMA" id="CKCECGM"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="4">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ75360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="203" mass="23799" checksum="77AC68D9055D0DF0" modified="2013-03-06" version="1">MNVSINSNSARTTPFMEHGFIKDENNKAKEQKQAYETSLKLPIIANKLCKYCDNPRIDFEVQQAFGISVCNECKYTKLRLINKTAIIKEYLLGNEDLKDVKCLTRPNPKKGTWSDMQLFQLEEIETIAKRKWGSIENIENEKERRKELLLDKKKKKIRKRVKELRKCTLIEDRMKINTHKHTFILVDGVCKCECGMVVDQEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVQ4</accession>
    <name>L7JVQ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVQ4"/>
    <dbReference type="FunCoup" id="L7JVQ4">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1551"/>
    <dbReference type="HOGENOM" id="CLU_062828_6_0_1"/>
    <dbReference type="InParanoid" id="L7JVQ4"/>
    <dbReference type="OMA" id="HECEAEG"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="1">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="124" mass="13435" checksum="52EC0C4441655F49" modified="2013-03-06" version="1">MATAKRGKSDPIHADDLVDGRKLFGGSRPRRSLKQTTGLRIARDGINAIALACGFFIAEILDLARHECEAEGKKKITPRHINLGMSKDDEMSVISSSWLIKGGGVKHPATAEMLRGKAKPSQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVR2</accession>
    <name>L7JVR2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small Nuclear ribonucleoprotein splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993988">
        <property type="protein sequence ID" value="ELQ75126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVR2"/>
    <dbReference type="FunCoup" id="L7JVR2">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1960"/>
    <dbReference type="HOGENOM" id="CLU_076902_8_4_1"/>
    <dbReference type="InParanoid" id="L7JVR2"/>
    <dbReference type="OMA" id="DGRYMYG"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="106" mass="12662" checksum="176C36A571B08A0C" modified="2013-03-06" version="1">MNSIFSGTKDYEIFLDNHVVIYLHDGRYMYGILRSFDQFNNITLEQTVCRIFIDDEYAERRLGLHVIRGENIILIGVSQIKLRDLVKREYEYVENKLSETIRNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVS2</accession>
    <name>L7JVS2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative unusual protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JH993986">
        <property type="protein sequence ID" value="ELQ75136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVS2"/>
    <dbReference type="FunCoup" id="L7JVS2">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1921"/>
    <dbReference type="HOGENOM" id="CLU_502663_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVS2"/>
    <dbReference type="OMA" id="SMVRTHH"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="124"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="542" mass="63385" checksum="739E1296B9B542EF" modified="2013-03-06" version="1">MFTSIFSREPYNRPKYRYRYHSPYKFPISDQLYRLCRLSCSIIPPILAYPFPSEIYYKTVYSFFANNGYVVMKLGQWLATRTDLLSIGLCKVLSTLHNEAPAHPFVDTLEILRNEMYDISLFHFVTHKPIGSGSVAQVYKVIINDEIRTFSFFWKHLFNFPQNFFLTDSRQIDTKLDRTKNSREILRKHGHKTLAIKIIHPNTTKDVYLDCQILTNAAKVLSVIPALSCLNINEQILHFQNEILKQIDLTGEERNMKVMRHLTRYDKNILIAEPIMATKNVLIMEYLEGESIVSRSGRMSNQIDNNRTNNEKTGLPLHDTKNESSKEFSKNKNMNFGLFKKQNHSLSVTALTFFVKSLFYNEFIHTDLHPGNVSVTKSNKLILYDFGLTKFLSHAEHRNLIDLFCSLFIEKNGLIVGDLLVERLACNKNVDKKKFRGEINELINHYFKQVLRMNGNSTRNDAYMITKEYGFKAIRLFNKYNVKIDYKYNQLFVTAFCFDGILRQIQPDCTFYGELDQLIWKFGPTLYLLKQHMVRKLFGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVZ8</accession>
    <name>L7JVZ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993941">
        <property type="protein sequence ID" value="ELQ75604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1467"/>
    <dbReference type="HOGENOM" id="CLU_046372_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVZ8"/>
    <dbReference type="OMA" id="MRINFRE"/>
    <dbReference type="OrthoDB" id="10466117at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="470" mass="54307" checksum="41709BB7EED5C708" modified="2013-03-06" version="1" fragment="single">VKIANDQVLKITTKYNSLLLKDCVGRSIVPGIQIGVNEHIDLHSTNFIQFYGVEENFYNGRIMRINFREKLLVSHKIRIARLMDLKLCENIGPEFKYGCETLLLFNTNGVIISLDNKFKKIILSHYYQNFLVYYLSYSIYEVVISSCYIDHHILVFGNSTKKIRFYRVNFGNSVVKINHECENIIIKKTIGSFVISNIIRKSSLHGGSLYLHDGVFIFENDLFKTQHSLLLKRVVIGQRTIVRENVNVVNLISVVIRKRAVLKINDDCEILLIDNCDGNLDFSGCTCLKSLTIKNYKFIYHKNIYDNLLSLHLEGLNINTTIRLEENIKTVKLMDVTTGWFGSAKIVVNYEEIYVRNFVGNLDISNLFDCFKKLFTGKTITIAYEMISDKFGRTMFFNNICLEKDYEIPNDVESVILRNFKTNGKAKLKINKTCKYFKLNVYQGCIDVSKMKDIKEVVFIGCLPIFKDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW08</accession>
    <name>L7JW08_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW08"/>
    <dbReference type="FunCoup" id="L7JW08">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1425"/>
    <dbReference type="HOGENOM" id="CLU_789950_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW08"/>
    <dbReference type="OMA" id="VMIWIHV"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="339" mass="39933" checksum="D205B509E7F7860C" modified="2013-03-06" version="1">MYFFISLPVDSRTSAINLLTHLKKHRLDVFKLNVPINHWSSFGSMIELTEQLDGLCRQVLDLFNKLLTVDRDFVKSPSFVKNVDLNNKIERFVWPGDKYPRAALNDMFETFVDELALIRKNFELRSANYERSKRKMEDIRRRKNGTLREVDLANLVTQNDDFEFLEYFYVLIDRNERLENVDVEDLICVKEIAGDEEQRLVQCLGLRSKREHIEKQLAAKKYIVKRFESTNEDVDRIAIDFSVVEKGYFTFIDTYLLETFDLLLCVKLTKLYVDSVLQYGLPNSYIFLGSKDKSMDNVVRRWIKALKNFDFGNRVVDYKAFDERVAYNSVEEVLVDGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW13</accession>
    <name>L7JW13_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chaperonin complex component, TCP-1 delta subunit (CCT4)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993939">
        <property type="protein sequence ID" value="ELQ75619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW13"/>
    <dbReference type="FunCoup" id="L7JW13">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1430"/>
    <dbReference type="HOGENOM" id="CLU_008891_9_2_1"/>
    <dbReference type="InParanoid" id="L7JW13"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="535" mass="59833" checksum="267AA4EAD564991B" modified="2013-03-06" version="1">MKTTDRSKKIYDSNIDCCTSLKSTLSSSIGPFGLDKLLITPSNKIVVTNDGSTILKNLSSFHPITKILNNVSMTQDKVAGDGTTSVVILTAQILENAKELMDENVHASAIIRELGRIKQIVLEYFERSKIRVENFASAVRTSLSSKVVSAAMDELVPLALKATQYEKLKVVKKLGDEIENCTVVDGYCVKIKSDEKNSEVVDEYAIEQLSTALQKKYRVALLQYNLSAPKPNIDSKIEIEEKIEEIIKEEREYVFNLVKKLKMNRVEIALVQKSILKESVSDLAEYFLNKLKIKFFVLEREEIEEISRVFEMRTSSTNNIITYDMNVSFYDDIILLNETETRVEKTCNGENETNVNEKVPVAEKEGRKSEVSGAEGVTKGDASANNHGEKRRKAEKRVGSLIVRASDNILLDETERSLNDAICVARCLKDEPYIVPGGGNVEMNISRLHENEIQKRIMSAFVIIPYFICRNAGLNFYKIGQVADNSGIDCVSGSVENMIEKNIVMPVKVAKSYFGLALETASFILSIDDILPSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW16</accession>
    <name>L7JW16_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitinyl hydrolase 1, Protein containing Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JH994005">
        <property type="protein sequence ID" value="ELQ74952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2114"/>
    <dbReference type="HOGENOM" id="CLU_2607717_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW16"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="79" mass="9466" checksum="DC9A19399A0308B1" modified="2013-03-06" version="1">MEKNDFTLPKILVISAEPVYRKQLTLPLSEKLVFKNKTYNLRAIIRRKRKKNNKGHFYTIGKRGNSWFEFNDEIIPQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW59</accession>
    <name>L7JW59_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphoglucomutase/phosphomannomutase</fullName>
            <ecNumber evidence="9">5.4.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="9"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW59"/>
    <dbReference type="FunCoup" id="L7JW59">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1321"/>
    <dbReference type="HOGENOM" id="CLU_022890_1_0_1"/>
    <dbReference type="InParanoid" id="L7JW59"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="7">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="7">
        <location>
            <begin position="122"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="8">
        <location>
            <begin position="299"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="6">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="515" mass="58006" checksum="C55A7A2A2116D873" modified="2013-03-06" version="1">MDIKSFLTKNLPPTLKKPPTTLHYGTSGYRDLPSKLPISRTTLCAYMRSSTLAGKYIGILLTASHNDARDNGIKLVDHNGEMFDRTWEGVVDKIVNCEDNAFYSELNKVHRNYGNFRRFGDGPKANIIVGRDTRESGVKLVEEIVALMGHFNCSVVDYGVVSTPQMHYLVAQSNRLNMVMDKERYFDMFIDFIRFADLREKVNVDTSNGVAGYVLSSINERLSAMGYFDQHGDGEDEQVLFVITNKDGEVNDRCGAQYIQYEKQVPYHLENAKGLYASFDGDMDRFIYFTVNGTLTYIDGDRQANILVKYLSEKVSCKIGCVLSDYSNSAAVNEISKYCEAVRARTGIKNFIKKSKEYDIGVYNEPNGHGGIFFSKEEMGDEEINNIIKMYRESIADPLANFLLLEYLRKTRPALFEETYVPFPSRMLQVCVVDPTVVVNSESLDVVEPVALRNVISNVMKNGKGKVFVRPSGTENVIRIFCEAKENVDVMCLTIAQAVYDLCGGVGKHPEISYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWA6</accession>
    <name>L7JWA6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWA6"/>
    <dbReference type="STRING" id="72359.L7JWA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2017"/>
    <dbReference type="HOGENOM" id="CLU_040462_3_0_1"/>
    <dbReference type="InParanoid" id="L7JWA6"/>
    <dbReference type="OMA" id="AGCAFIF"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="328" mass="36388" checksum="3E28B3BC2A5A7E97" modified="2013-03-06" version="1">MMDFFVLSTLIFITSLILCLIPRSLSRIDNIKKFYPHITVFAAGFMLAMLLLDFIPHVAGICKHGNSPHNSAHHSISECKNPLKCDLHKNDEHTSGNEGNKHDEHHHHDHGHDHSSGFFGQNLGFLIAGCAFIFLLSIDSIVLHHSHCDNDKIVQMNDGLNHGAHGHSHTHDQIGTCNTSAIKETKSKIQAIIFILALSLHSLFEGLAINKQRTFGIFEVGIIVHKMLESFALGFTVHMAEFSFAYTIVLITVYSMLTPLGMAIAYFLPFNKMLNTACNGLALGSILFIVCVEMIPPNFHSKSSDFIKIASLASGYVITAIIIYCMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWA9</accession>
    <name>L7JWA9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1722"/>
    <dbReference type="HOGENOM" id="CLU_461648_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWA9"/>
    <dbReference type="OMA" id="RWYCCEL"/>
    <dbReference type="OrthoDB" id="10440689at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="591" mass="68021" checksum="9780529F7C3121E2" modified="2013-03-06" version="1">MNNMEHCFKLPIRSTNTIDKLLNYVNKNRTNKQSVYQYIIDEQIDLGIRLDELTDSEHQIKFVMLLRRILPNNEFMSIFNDCDVQTLGMACRNVRWYCCELLIRYNRTTKIFGYRLNGYNIFADQNCRTNTSTGVLYVFFNHSDIKLYDNKKIIPLSYKTLLKYTVDATKLILYKERIRIELYIKDICSYTIDEKFTELGITRASVPDGRACSDREISNAMKVSVPIKNIYMKSNEYTCNDSIERNLVHKKVQVGDGLEFTITSKLKRSVHFDFRKAFDDSLSDSCSGNNDQINIRSADQKVKEENELAVGTVTANTKSSNECVIKDCIKANKNILSPDNTCSLNNTGVIGEKAKMHRECLSEKKTSIEQDAKEDATCKTDKTGNESFLNFNSCTDESDHEVIHNGDNKTDKASSNASLINHSIVSECKSETFGSDINKIFGVNIRNEHLQSFHQADQNEREENNHSRSLSTKKSENIFNSCHIKSSSSFKATKRRKSQRKKRILLESVSYTTKHMMYHQSNVRSTITSNGCAELVKDTATKENTKYKNIIYEYMSNYKNMMYGAMSAVRKDLKVLSKGIKYLINYKIKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWN1</accession>
    <name>L7JWN1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar H+-ATPase V0 sector, subunit d</fullName>
            <ecNumber evidence="3">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.3.14" evidence="3"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWN1"/>
    <dbReference type="FunCoup" id="L7JWN1">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1367"/>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWN1"/>
    <dbReference type="OMA" id="ETLFPTC"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="327" mass="38528" checksum="9438B79280307324" modified="2013-03-06" version="1">MQNEYKENDDYGYILAEIHGRQSRILTSSEYKALLQSDNIDDVIVKLQGTTYSKYLSDSMEKSKVNLILSLERAFKHEFNEIYERSTGCLRVLLTFFLESYKIESFIYRVSNPEEPEEELGFFVELNTLKFSNDMREVKKFVIDETFLSRYFDRINVENSIEKNNFQIIKRMLMKYHIEDFYGRINGDMGFMRTVLEVMGSIQIIEIVLNTMHTNITADNRKKLFPDVNDLDARTIHSLAECNTIDDLKAILGKTSYKETILSKDLLNGLQFHVLMVYYRSFSVFNDLSCVFCYLKLKEQEIKNICWIVEFLGEDEKDVMENIYCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWN7</accession>
    <name>L7JWN7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993954">
        <property type="protein sequence ID" value="ELQ75476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1580"/>
    <dbReference type="HOGENOM" id="CLU_1890847_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWN7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="135" mass="15692" checksum="8F3136434A8ED4D1" modified="2013-03-06" version="1" fragment="single">VLDNVNFMQEIVLNDQHNDLLTTTDIDFRNYIYELQLSNSLPDESITSDGMVCININSMFQGEAFKNITFQKLILQLSNAHFNNYSLSIRACKIILYCSDSTIEASGELPNILTEFYIWNSRITNTIELHYYFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWQ1</accession>
    <name>L7JWQ1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1392"/>
    <dbReference type="HOGENOM" id="CLU_1797804_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWQ1"/>
    <dbReference type="OMA" id="YLETRMT"/>
    <dbReference type="OrthoDB" id="10386993at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="144" mass="16464" checksum="45F1145973C005B2" modified="2013-03-06" version="1">MLFLLLLFKNNKKFLKIAIALLLLVFVYVVCFMVYILKNVVIEIASIDIVDGYIETRVSVCNDTPFDVYLNDLRLQLNVAELSGAIHKNRMFKGTRIAGDSTTRLKFKFHIVQEYEVNAVQGHVLVVLSKFYIKVPLKHEIGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWW6</accession>
    <name>L7JWW6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993902">
        <property type="protein sequence ID" value="ELQ75924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1111"/>
    <dbReference type="HOGENOM" id="CLU_903688_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWW6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="308" mass="36544" checksum="6BD5E6FDE9DABB9C" modified="2013-03-06" version="1">MYRYGLGANYYRPSRVKDDRVYDVESIPEINTEKYEKIMFEMGVYETAKKLASNNDKIQSNHPIVREIEELKEKIYRSDHELTFDQYRYFVNNYERIASEYDERRVEVTRTDLLKQIREIEALESTNPGLYKAVKPTYEAVKKWYEQNKNKNEITCHDFIRCRAELITSLEAAKEGKIVGTAGQGLNKELTPDNKRQESPPASDTAASKIKNTRRKQKKVANVFEKVFKGFYRWWLRVLHIARDESDDVQSRDVFEEIPNRTKLERKIPRSIDPSFGDDNQNLDESEEAEDENKYNRGRQREYIHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX34</accession>
    <name>L7JX34_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993912">
        <property type="protein sequence ID" value="ELQ75865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1179"/>
    <dbReference type="HOGENOM" id="CLU_1058406_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX34"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="233" mass="27508" checksum="537A9056C915A36F" modified="2013-03-06" version="1">MKKNTIIVITAIATIIVMFILLLYVSHSMLRAVDNKYKTIVDKKLNESAELRNMFLDGNRRKNTFLGVVSATINNETKIELRAQMTDKNYSKFKWKFENLDNDEDRYREWICGYALDPRPFNFRSIPPEKLAKYKLLAKKNIFVRIAAKLFRNFSVCIVDRHIEFILHSVPNGKRNIYIILVDEKRYMIYRFYVDDKEKTVKFNDKMIVMFKDDNALPISYGLISALNLAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX88</accession>
    <name>L7JX88_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993902">
        <property type="protein sequence ID" value="ELQ75925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1112"/>
    <dbReference type="HOGENOM" id="CLU_1464713_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX88"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="185" mass="21829" checksum="80EB2DF36BE1A756" modified="2013-03-06" version="1" fragment="single">VTIKNTIYEFIRKSVEKAYNKFRTEERNKEPVEVGYYPFDYDRKKPEYYFHTETIYINIIEPMQRRAASHMESEIHIYDTNGSPVCVIPLIEFDLNDLYKEFDDFYAKKKGMVTAFEGYLVNSILEFINDKNVTSSNLLRHIDVICHGISMELNFVKQFFEVLRIKKENSCIVTVWAQITTGHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX97</accession>
    <name>L7JX97_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993901">
        <property type="protein sequence ID" value="ELQ75935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX97"/>
    <dbReference type="STRING" id="72359.L7JX97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1101"/>
    <dbReference type="HOGENOM" id="CLU_1016315_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX97"/>
    <dbReference type="OMA" id="TVKCEER"/>
    <dbReference type="OrthoDB" id="2196350at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="274" mass="30134" checksum="B3A5BC4995601370" modified="2013-03-06" version="1">MSAAQPQSAGAGEAPPAPSQPPAGVAPTVKFARRLEPIIILQDYDRCSEADFMICCGKGNVSKPGRINFCRPACAKQCASREKVTVKVPETVKQKIKVVETVTKTATIDKTVRESQFITVSKTVPVTEKVTEVKSKTLTSTVTVPQTFYKSVTLTKNISVPYTVEKTETKLLTLYQSRIIEKPVTITISRVVLSTFTKESQHFSTVQEIRSQYVTVTTTTDKVVYSTVKDEPAVTINKTVYIPELEGLDCVPDCVCVDLECVNPCNTVKCEERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXC0</accession>
    <name>L7JXC0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1343"/>
    <dbReference type="HOGENOM" id="CLU_1579611_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXC0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978852" evidence="2">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="169" mass="19738" checksum="5917D7F85011019D" modified="2013-03-06" version="1">MLLLILILRLIQCGTNNSLENNPIMDIAFSKNSEQEGYEIEIFLKREINTDVIFITGTETPEDENSYTVVKVVDIKSDSEEMKNTIHIPLKGSDLKLKEKTYSIQINERGHIYHTEPFKFDCEDCRYKLSREIKKKNCWGKFRYIIIGVILFMVIVIALLSIVVYKFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXD6</accession>
    <name>L7JXD6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0929"/>
    <dbReference type="HOGENOM" id="CLU_1171327_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXD6"/>
    <dbReference type="OMA" id="AYFVEMQ"/>
    <dbReference type="OrthoDB" id="10363528at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="237" mass="26986" checksum="33365AB29542C712" modified="2013-03-06" version="1">MNKKYKISLTAAIVCISIISVVLLCFYHLKHANKKFISLIQSNLIKKNTIELFGAAPYNTSIIMLSKVTLAQTDVLVISPSQRTLTNKYVVPLINYKGEKLAAYTIIINALSSLWMGFEHYRRCIALVKANVGVLDNENLFARVGSLLFWTYDIVLFDKFLSFFAKNIDTADLFCYFFKISNGKLSIIRMEIAGTKAVKKTCAKYYLGKYAENMLAYFVEMQSREMTENEVQTVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXG9</accession>
    <name>L7JXG9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ricin B-related lectin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993932">
        <property type="protein sequence ID" value="ELQ75731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1317"/>
    <dbReference type="HOGENOM" id="CLU_918885_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXG9"/>
    <dbReference type="OMA" id="HYDNDRN"/>
    <dbReference type="OrthoDB" id="2187273at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="334" mass="39905" checksum="BA53D8396DDFBC60" modified="2013-03-06" version="1">MFYLPSPNTKNQNIFVHMFITGTPIGDSFPPYITVYLLSTIIKLSLHILALVSICRIRCEPLTEEGYIYSVDERKFLDYQHKQEGLVFVEYDHMPPVFKMVETESGAVFIEAENGDVFDSSRSNYDLILFKKHGGWNQQFVLETVPRDMIKLRVGDRCMTTEKNMKYLTEVDCDTFSKKPGQFFKWISKKDENVVRDFIERCKHSGRRKRPRYDDEAYDDDEYPDGYSPRYPRRSHGQPYRKRPRVRRRGDGTRDDYDNEPRDYDRRDYDRRDYDRRDNDRRPYDRPYDAYDDSSYDGNDRRARRFDSCLGINEDDLRDKLYDLRAIANNNVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXR7</accession>
    <name>L7JXR7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING-finger-containing E3 ubiquitin ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993874">
        <property type="protein sequence ID" value="ELQ76110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXR7"/>
    <dbReference type="STRING" id="72359.L7JXR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0924"/>
    <dbReference type="HOGENOM" id="CLU_637927_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXR7"/>
    <dbReference type="OMA" id="NSCIRKW"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="437" mass="50037" checksum="134881B545241373" modified="2013-03-06" version="1">MVDNSDKCTICLNTYTLTDTHRPTSLECGHLFGNSCIRKWFNKQKSALCPTCTKMCRLRNLRPIYATQIIACENDGSTQRIIALQEEKNKMEMENLRLMTLVELLQKELKKSSTIKANGTADIVAYRFIKKCPFILKDRNVFVEYERCENVVLMTFCNEQAFGLKKIDGMDMVTVEIVFQLRYKEMAVSAGPGYTRTDTKDVRIKDLKVSPFNDSTAILCYENTVKMINTANNSVLMSVSLQEQVTSLSYDYTDRNVIFAGDLKGWLYRIDLAGDISRVQVGESAIHSIHKINGVLYCGCVSGVYVYDRTIEKYEMLTVTNLTGDDKNVLITVRDKSAMIMHVLVENNLKMAEENESSDDYVFNKHFFNFKETKRLRDRVCDNNMFVINNEKKAVMVYDIVGNVKKVFWCGEIIKAFCIGVDKIYVLTCKGFMIYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-03-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXS1</accession>
    <name>L7JXS1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993916">
        <property type="protein sequence ID" value="ELQ75851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1193"/>
    <dbReference type="HOGENOM" id="CLU_1031292_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXS1"/>
    <dbReference type="OMA" id="THLYRIR"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978960" evidence="1">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="270" mass="31983" checksum="244D2604CB3609F4" modified="2013-03-06" version="1">MFFLSILIFYTRFAQQVLMFKCDGSLPPITKNDETQLTLYNDLATIASQNLSANFATIKFYEDYLHKILEIIYTLLKEPRSLEQFRNEDSNFCALIHFMRTNYSLMSTYPRCLTLEKSAYYNELTQRYIKWDHPLFVACLENALVFLAPFANYIADYTKSKIKIPELNEDTIAFSFIHEHKSYIVLSKLYNSWVTYMLRIRRNIFTIRYVLDGMMRAMNKYGSSCKIDSDELGKIIKYLDKNYVNFYNENEENVLNLSLSKDEEENDIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXX1</accession>
    <name>L7JXX1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993905">
        <property type="protein sequence ID" value="ELQ75906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1129"/>
    <dbReference type="HOGENOM" id="CLU_2838364_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXX1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="66" mass="7886" checksum="C4BB66B907B673CD" modified="2013-03-06" version="1" fragment="single">VYKRITWECEEIYYRTHINVLYESITSVSSEKIHECIRIRAPLLIRINPNDISVYVIRLTIMSESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY73</accession>
    <name>L7JY73_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0610"/>
    <dbReference type="HOGENOM" id="CLU_130561_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY73"/>
    <dbReference type="OMA" id="YHIIILT"/>
    <dbReference type="OrthoDB" id="2189453at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="175" mass="20427" checksum="93325892C53193B1" modified="2013-03-06" version="1">MGKGSRGTAVDDLSDFVRIFHKNINKHKKLEPKHFKRLSRIVRNNMVSQFLKLLSTFTNNECIVIGRAIMKNKMDDFDELVDFLVSRKSKYHIIILTCTLCKGRKLKNVDSVRNYIKSFFGDENGINFYKLIMVAGRKYRDILDDDILAFCRNNEHPILKEVLKEYESQSCVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYC6</accession>
    <name>L7JYC6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0500"/>
    <dbReference type="HOGENOM" id="CLU_1327278_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYC6"/>
    <dbReference type="OMA" id="CYDARQL"/>
    <dbReference type="OrthoDB" id="2189917at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031537">
        <property type="entry name" value="DUF5092"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17010">
        <property type="entry name" value="DUF5092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="207" mass="24159" checksum="ECF906DA8D7FF449" modified="2013-03-06" version="1">MALILEKEGTKRCALEGGQTEIFTQKRFIDLISEAHSQSQDYYLARVRCVGMRKDKGVNVSGIYFCYDARQLCKYVFEMVIGPKGRKIQIKNFKDPIYKRTITELSFFRLCYDSETPLKAEYMGSYRDFLDSNCFRTKIFHKEDPLDALSVSFKFNKKKKMSVISRKKMFSIFITLILILCIVSILVVVVEKGHIKFVDDLHIQNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYG1</accession>
    <name>L7JYG1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993877">
        <property type="protein sequence ID" value="ELQ76086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYG1"/>
    <dbReference type="STRING" id="72359.L7JYG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0949"/>
    <dbReference type="HOGENOM" id="CLU_1416157_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYG1"/>
    <dbReference type="OMA" id="MVCRYLV"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="209" mass="24791" checksum="29D337147C9B6065" modified="2013-03-06" version="1">MFKSTAQFIKNWPSPSTMPKKKQDAQPKAKKDVKSTKEMKKELEEKFYGQKQSKALRAQLKKLDLLEKVQKKEQQERQKEREAEHNTRPVKPVVQASQEVVDQPVKSIMVCRYLVDALHNKSYSKGWICPERCGDVHVIDEKQNIEEFLEMQRASVASERLLSKEEYDKFVDRREKEEMVFERRRERIKSGYEMFRDDPTMFEDVDGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYK4</accession>
    <name>L7JYK4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation-transporting ATPase</fullName>
            <ecNumber evidence="12">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_0542</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="12"/>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="L7JYK4">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0542"/>
    <dbReference type="HOGENOM" id="CLU_001828_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYK4"/>
    <dbReference type="OMA" id="SGWKDPL"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1105"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1136"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1207"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1247"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="214"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="787"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="787"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ELQ76514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="1286" mass="144866" checksum="DC1895ED5A2A4487" modified="2013-03-06" version="1">MHNEQETLILKARTLAIPLIYLYYTACILSFGILPITMRIFPLVKIKWTTRRSSLDRCSHVLVLSNTSIEFVEVDVINLKKFKKCRNSVYAELKAYIRDDRVRVLTTNFMRFVYDYGKECFVRPSGRYSAPLSNHIMYGENTLATRTCTVLQIVVNHFTSNLFLYTLVCVFIWSQIDYLIYSVILLVMALYSVINDIVVDVRNKNNVDKLSRIRKSMNVFRDNQFREQDTKNLFPSDIVAIAPGEIEADVQILSGEVIVDESFLTGESIPVYKRKGGIVRAGTVVMECREDNEPFCLSNEYEMVRISALDDRGGKRRGARNSAGEKTGLGTISDGDKDVNTDGGGENDALEVNRYENRLEGTSSAGLNEEMRYEQIGREDDHVERTAAEMTRRDDHVERTGSSLQTKGDDHVERTGPALQHKIGKPYHKHVIGRVISTGFNTTKGTLIRNILLPTKPNLKFFNQSKKLLFIMFGIGTFISIFYFLFSLFHEISVKNALYYSFDLIVTIITPALPAAIRIGMNLSVKSLKRKHITCNDINRINTISEISTVVFDKTGTLTEDGLDICNVDVGMDGEVRSSSDENVCERFYVYGMDHGNNDYGDQSNYIRDSTDESTEITRETSTAVTIGKQHVSTQSDDNIRRTGPKKLKSDFLMHMGMSTCHSVVTINHECLGDPLDVKMFKYSDASMQDNTITISGDVPYQCTILHINEFDPTRRRMSVVVQFEQRRYVFVKGSAESIGGLLRSKSEVYDKRSKEYALEGYRVIAMAYKCLDEECETGDGTAVGSASDNFGGSGAGSDQMSDTLRNSGSATTGARGYSHGLAKDKANLKGDQNCGARGYSHSLTKDKADLKGDQNYGQQNEHDLTFLGFIVFANKLKGATIPVIHNLKQAGITCLMATGDNILTAISVAKECGMIEQDMPIIFPVLDEKNEIDKNEMEWCVIGEGSYYFDKLRRKLFKESNEVEYVVAIEGREFEELLEDDQIIEKTVVYARMNPDQKKMLCNRMECIFVGDGANDVGALQSSTVGLALNKNAATMNSAFVSDVLDISSVEVLIREGRCALVTSFCTFRFMLFTSVNQFVSFIVMMLFFVFASEVQTMHYDIAIVIPLAYTIGLFMCSDTLSLEVPRCEILSVRFVFAFVMHLAIDCVFLLCCAFGRHSGSAHQYEYKTAMSTLVFFMTAVQAVNKGIILTDGQPHREHKMRKRSFVFVVVLSYVVLVAVLVLMLLNSIVVKWYEFEVLTLNERVFLVAGVLLNTALSFLFEYALKDRVLEMFWEKDDVTSEYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYL1</accession>
    <name>L7JYL1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0547"/>
    <dbReference type="HOGENOM" id="CLU_2051300_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYL1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979260" evidence="1">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="13863" checksum="35A4EACA4D181294" modified="2013-03-06" version="1">MQFLGFFLIVYAVCCALMHEKAKEVKSEKRGACGNKKILGAPTKILPESDKLEEYLKEYYSVANDVVDAFNSLVLRADLNEARFDIQLKKLLHQCKQHMNNTTNFKKLYCYPLEIIVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYL6</accession>
    <name>L7JYL6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LRR containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993844">
        <property type="protein sequence ID" value="ELQ76524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0484"/>
    <dbReference type="HOGENOM" id="CLU_425252_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYL6"/>
    <dbReference type="OrthoDB" id="10321360at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978894" description="LRR containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="74523" checksum="B6E9680B9FE04814" modified="2013-03-06" version="1">MSKFLFFVFAEILYCAYSLDPVKVQNPLYSAISNGPYYEREKTVKIVELVRRFIAKSGCVGLVQAFQAVTDQSLKTRFITVVRKNIMFVINNESFNLRFVHSDHELRVAKNLHLHVVDVNIDPPALGSCVELLRNLRFDYMKAVVKDHRGIQEYLPNILSCFNHIIKLDLEIDHITNTSMQELSILNLQEFHISVSWLKLEHLRKFLNFESLIKEIIADNLQIDNLSQITAIILNKLCHKCVIKIQNCCFNKSQDAFMMPELSNQQSVVKIILNNLHPLPHSRNFWLELNSTSLQPICTWRSSVKELTLTFENELYVNELLWCCIGLKILTLQLAKIVNGFSFMISENLYPTLEKFKINVKEEVSSKAQSLNEALQRFKSLVNIDIKIKFCDCSGENMFHELLIPSLESLTIDSNALGEKFFKYAMELYELEDVVINWPTNTTTVHTMTMLSDLTVLPALTNLSLDRISNTHEWQILDNCRDLLSLEIIAPIDFLLITSTDSQLYRTLESLTISLDTSIIKHVCLTFIKLEFLSLEVTSENIDRRVNNDAVRYFMQANFSNSINNTLTSLLLRQSISFDLTLLSMFTFPVLACIRLEISDLYVQGQDEQFCNDFCERMSEQCELLKKLYFNFKCSQQYMAFQCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYP9</accession>
    <name>L7JYP9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative WD40/YVTN repeat-like-containing domain, WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_0303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYP9"/>
    <dbReference type="STRING" id="72359.L7JYP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0303"/>
    <dbReference type="HOGENOM" id="CLU_903428_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYP9"/>
    <dbReference type="OMA" id="NTWDLRY"/>
    <dbReference type="OrthoDB" id="2189754at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ76588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="322" mass="36363" checksum="BC07F4FF7F9709F7" modified="2013-03-06" version="1">MKQGTRPAISRASIYKPLTVFTKRLTNYSFLCCDTFSECVISALGDDSGHLFLMDTDIDERKFLNTEIGVSSSAIFDVCWLTNSLIGIASGDSNVYLFDVFKGEFTQRRGHTKSVRCVKHAAGRVYTGGSDGKVFCWDVRSKDPVLELNFYPRGHKMVSALELNREEEYTIYGTATPGTILNTWDLRYTKRGMYISEQNSIANAITNSIYHKDRHIYLLLSNSGVLRLTETGTFMNYVQPGSTYGVSHGKIDYSAHLDLVLAGFANKVVVFDAKYTHLACTHDIDPINGLNCIRRNNFLTYDEYGRVTIYEMVFKETQVQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYS0</accession>
    <name>L7JYS0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993906">
        <property type="protein sequence ID" value="ELQ75902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1147"/>
    <dbReference type="HOGENOM" id="CLU_3360010_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYS0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4394" checksum="122AFF49930A3B3A" modified="2013-03-06" version="1">MSSSERCKILCGGYFRHRRVNPQGMPRQFIFRYCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYS1</accession>
    <name>L7JYS1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 2A regulatory subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0863"/>
    <dbReference type="HOGENOM" id="CLU_466604_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYS1"/>
    <dbReference type="OMA" id="NDYLQCG"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="585" mass="67892" checksum="479B0E702131826F" modified="2013-03-06" version="1" fragment="single">VYYFKKAFLIISPCPSFFPSPAHLQFFLHFFLALQMLHQSTISAYHDLLLTTTDLSSTVASMLTAPVFQEHSNLSTLINTLLKSPFYVHRLAVCHLLPYASKSVFYVLFNDNIQLVSRTAMEMLPAGMLSHNEILECLDALVQRNDYLQCGAADLLCRLEQHSDKVHHFLRSVSWRVRFSLAKKLDRLDVFYKDIYDVLKDDDVLFIKKAMICALRDDDVLYFLRCEDEEIRCEVVREIWRRAESGSGFMYLREYYGDKRGDGNDENLSRVNDNVRDYDSRDNVSRDNVRNNVRDYDSKDNVRDYDSRDDVKDRITKDDNNVKVTINGNVNENLHVNENINVNTNDDYKISKEDKKDQSNAHDSLLEGTLAPINNDEHVYLAASHAGDEMSTEEYTQLIANTSIHALKHDLPSFLMKDPSPKVKFNLLKLLKTKSLVQQFVTSTDWREREQALEYSLDSDLYFRFLVDPVAHVRCKAARLFRQPLSSATISKLKEIVRSDNYLYRMNVVHVLVSNKHESMRDMLGVLARDRIVNVRDKVLSVIESERAVYYIDVVEQMVDDDDEEVCRRAEQVLHVLRECKGMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ44</accession>
    <name>L7JZ44_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993887">
        <property type="protein sequence ID" value="ELQ76037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0988"/>
    <dbReference type="HOGENOM" id="CLU_3351391_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ44"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="37" mass="4352" checksum="DD635975F9F49214" modified="2013-03-06" version="1">MFVQRYLNMLELNGDKALALYEPDNQKMCSIWTTSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ56</accession>
    <name>L7JZ56_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterochromatin-associated protein HP1, CHROMO domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993855">
        <property type="protein sequence ID" value="ELQ76331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ56"/>
    <dbReference type="STRING" id="72359.L7JZ56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0707"/>
    <dbReference type="HOGENOM" id="CLU_045874_2_0_1"/>
    <dbReference type="InParanoid" id="L7JZ56"/>
    <dbReference type="OMA" id="NERCPQV"/>
    <dbReference type="OrthoDB" id="2194250at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="138" mass="16380" checksum="B70B6221DB5B6CDB" modified="2013-03-06" version="1">MSDDNIYQVEKIVDSRIYKGKKQYLIKWEGFPSNENTWEYAKDIFSKELIEQFEQERKQKKKGAVKPKTVPEVTNEWAREVNNIENVYMDEKKNKLMVDILFNSGKKMSVDAKTVHQKCPVALLEYYEKNISFTDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZF7</accession>
    <name>L7JZF7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Negative regulator of transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZF7"/>
    <dbReference type="STRING" id="72359.L7JZF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0399"/>
    <dbReference type="HOGENOM" id="CLU_1185753_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZF7"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="1">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="234" mass="28057" checksum="2B2139A3A0C55EA4" modified="2013-03-06" version="1">MCQNIISFLLRTNDEINMELMFYFLKRLFSFSFKCQCEVSSWLIYSNDDRKFNIKLYVGFIKHNLIRLQELDQYFSQKIRDDRYLNFIVALLNQLNMPYEFINTIEAVSKLNEEKYESRIYNMLKEVSNITFYNHKELSGSNLFDEYVKIMKYSFSPEKYLGTFFNVLNEKVKEPRPFIVKCFIISWDHFVRFYKIPSGFKNLKINCLTHVAQRVQFKSWHGGGARAFLQLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZG6</accession>
    <name>L7JZG6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0178"/>
    <dbReference type="HOGENOM" id="CLU_3160276_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZG6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="48" mass="6048" checksum="B65D310CDCD544A4" modified="2013-03-06" version="1">MKSIDGVKDTDRERLNKIYEYLERDREEDDRMVKFLREFEDRLDKYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZG9</accession>
    <name>L7JZG9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZG9"/>
    <dbReference type="STRING" id="72359.L7JZG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0555"/>
    <dbReference type="HOGENOM" id="CLU_039781_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZG9"/>
    <dbReference type="OMA" id="FYAPTIC"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="265" mass="29331" checksum="3CA394749C284493" modified="2013-03-06" version="1">MDSKSVKKLLRIYKNSLFEGRNVYLACKEIAKMTKYKVFMALTANILNNGTYDLLFSLIEKNMVHVVVTTGDFVVYDILRTLIGKDLNEKAFTAEDEETIKNFIGQIALENCGATIPPSKFIKIIGEKLGFNSILGQAARNNVHFYAPTICDSLIGIYCTDIHVDSLKDVYNINYECFFVKKTGAIILGTSVIKHTVLNANLFKNGLNSCVIVNTCNEVDGSDSGGDVDEAISWGKIRGNTTSVKIRADPSVIFPIIGSYWLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZH6</accession>
    <name>L7JZH6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0565"/>
    <dbReference type="HOGENOM" id="CLU_305879_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZH6"/>
    <dbReference type="OMA" id="MINGIEY"/>
    <dbReference type="OrthoDB" id="2188879at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="1">
        <location>
            <begin position="631"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="923" mass="106188" checksum="02E006A91888A2C9" modified="2013-03-06" version="1">MYFAMRTIKKSSSAVCAANVFYQQRECLAVSTGKYLNFYDIMDGKFHKIGELQLGSFVVAVIPIENKKFVLISLDNQYVVVNDQKVVKRGRVSKERFWRVENKIQKCVYANGKIVILFNNNKLSIMHVASNSVKIDDNLKDLLAYNVYDILVHKNEIIALLGDIEGKTYIHHYVFKENKRGIVFKDRRIMSNAYRILMANDRLYVFRDGVVTVIDGDSHVDMQFANPSMINGIEYKNGLLLTMEDRELVYISDKVNILHRFSDTIDNIVPTSGLLFGLSFYGHSILFTIDNAVTITDALENVSQPTNLHFRKNLHFLSGMNFNNSMCEMSYKIPVKYEEYINFPKIVKRTWKYNEYLIVSFLNEGLIMKNKTAWEKVGEVQNLRVLADCCVFNTKTHIYRLTTFLTAKESKSIVLSDIDDERVVVYTDTKEIDVYDVNTLVIRCSTAFDAEISLIKWVSEMVLISTFDNQMYVLDKELAKIKTFDFECLRAAERVSSAYMIVCTLTSKIYVMDLATQQARLLFKMEHVTQLERYGDGVFAIGKNVIYVSKQLVCYDTELSELSSMHCGNILLFTRENSIFSVNLGAEPVFKIRRRAINGEGLFLSKSRNDYYLGYRQECSSILVHVRKGKEHVMKIPNEVIRSAKRINKYLVVATNYKDAHDNNYSRLVLLKKMTKIYEVCKPGALFSIDVSKDYVATSHGVFLTVYSVLNQVLVELAQIPCPIFPWKIRFNAYNLMICDVFRSFSVYQFDPETNTIIETSRCFEKFVADEGVPIENEYLVSDAIGNLFNCVSDDMDNEIIKRGSFNYQEGVICIERGSLNVKKDRDTYYFSTSSGSIGVIKKYEDNRILDQIKNVIEVIGANLVFNYNDATAYETEDGTKGSTCFIDCDVLGGYKEYKDVILRFCSNYEEVEPWIEELINIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZK4</accession>
    <name>L7JZK4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0094"/>
    <dbReference type="HOGENOM" id="CLU_2689554_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZK4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="74" mass="9101" checksum="6A0ABA6283D75347" modified="2013-03-06" version="1">MHKYLTRRAKRVKALHRRINKIRPGILVRNTLSQQDKEKECRKERVRMKIRRNRHNQPIMSGKDVIMRIERISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZN4</accession>
    <name>L7JZN4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MutL, dimerization, DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZN4"/>
    <dbReference type="STRING" id="72359.L7JZN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0067"/>
    <dbReference type="HOGENOM" id="CLU_1788169_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZN4"/>
    <dbReference type="OMA" id="DIYECRI"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="145" mass="17017" checksum="5FD4ADC3F1EAF93E" modified="2013-03-06" version="1">MVMNAVSISNKSDNAGLYGRKILSRVRNTDTLKCTKEQISNARVIGQFNNEFIIIKNEHNVFIIDQHAIHERIRLEKYVSIATIKGTNYDLEALKEKACKGAIKFKDRLNIYKMKEMVRWYRYLKYPFICCHGRPTIVYIGRIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZP3</accession>
    <name>L7JZP3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molecular chaperone (DnaJ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">THOM_0830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993861">
        <property type="protein sequence ID" value="ELQ76197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZP3"/>
    <dbReference type="FunCoup" id="L7JZP3">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0830"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_1"/>
    <dbReference type="InParanoid" id="L7JZP3"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="7">
        <location>
            <begin position="133"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ELQ76197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="383" mass="42422" checksum="37582808D78249B0" modified="2013-03-06" version="1">MHDNKGYYKLLNLKPGASVSEVKKAYNAMLMKYHPDMGSIAKNLKTIEDEAERASKFEELNEMCKKLNDAKTVLTDPDKKQLYDQGVDESAGGYDMSGFDIFEFMGSRRDKGPKKVANTEFHVKFTLKDSFLGRKKTFSVKREIICTKCEGRGGEKSTVCATCKGEGEIAIKRQMGLIFSLDRSACPDCNGNGHIVEGALCTECKGQRYTQKQESVTVTFDKGFKNDDTVVCRGKGDEHVGCIPGDLVLIINIKDDPHFKRVENHIVTTADIDLYTALVGGTITLRHIDDSVLNVKIDKIKNLREGVIIVKGAGFPGGDLYINPNFVYGNVKEDELKKVLPCPKLPANNGVACVGAEGKLPSEKKRSANSFKENIFSQFFRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZR1</accession>
    <name>L7JZR1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Puf family RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZR1"/>
    <dbReference type="STRING" id="72359.L7JZR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0234"/>
    <dbReference type="HOGENOM" id="CLU_584221_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZR1"/>
    <dbReference type="OMA" id="CKKDWEI"/>
    <dbReference type="OrthoDB" id="2193727at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="472" mass="56111" checksum="1D5895DFE676715F" modified="2013-03-06" version="1">MFIMWCYKNNFIKFLSPMANMDAMEGRTCYKKTRLRDKSADSKKVKRVDGENSNNNSTFSKNTAGVQLSRNKERNTKYEIRGKTKHNENDLKRSNRKRHADEDNQEDNDPYNKSPGISKSIQKSKTNEMIDLCKKDWEISRKKKVPKINREDANTRIYKTLKGHFYKVLKKRTGSKIAQTLFKYGSATLKDQIFEEIYKHIPELCQCSFSIFFLQKLLNTKYLAKVFELMKKNYRKILTSRVGAFYFDEVYQHVNVAQKEEIIKEIMGNEVKIFYGGKPLQEIPSEKFNFEVILDKLMNKGLTNLEITHDLIFYHLMHYTDTNERASFMKTLSSFFVDLLHTERGKSIAHQLLKENENHKILFKKTGEYIARMVENVFVHDILLEMIRHGKEKYVSKYILKPLRTSMDVFLNTNNFDHLLLELINMHKFEILRDKFTKTYKRNEEIYALKYEKVFKKLKDYDVEEKICIEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZY0</accession>
    <name>L7JZY0_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ERAP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0752"/>
    <dbReference type="HOGENOM" id="CLU_090220_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZY0"/>
    <dbReference type="OMA" id="NDNLMMY"/>
    <dbReference type="OrthoDB" id="10339792at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="1">
        <location>
            <begin position="60"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="214" mass="25170" checksum="9DB35443C4A03B0C" modified="2013-03-06" version="1">MKHIFYDDNRNIIDILQNLVKHRLNFDLKEEVDMNQMSLRASLLGIAVNHGIDVKIGDDIHPMYLLSYYTQKMMANNDLDYFIDLYKKSTAEIRTKVLVAIGRTTSLEVYSRVVQLMVSKTIKAQDKIHLSASLMNNLNFKEHYITYFVENFEAIRQALNDNLMMYVVEQVVGWARDVTLLQRSMTTYDMTNFSQAYARALEKAQYRIDFRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7K004</accession>
    <name>L7K004_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K004"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0112"/>
    <dbReference type="HOGENOM" id="CLU_3210262_0_0_1"/>
    <dbReference type="InParanoid" id="L7K004"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="45" mass="5160" checksum="67A8FF7FBF4F7CEE" modified="2013-03-06" version="1" fragment="single">VNLVAYFYSLMLSLQSILKLSKESFPALLLCVLSYILPTFTYLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7K012</accession>
    <name>L7K012_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K012"/>
    <dbReference type="STRING" id="72359.L7K012"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0675"/>
    <dbReference type="HOGENOM" id="CLU_1230672_0_0_1"/>
    <dbReference type="InParanoid" id="L7K012"/>
    <dbReference type="OMA" id="ANCENGC"/>
    <dbReference type="OrthoDB" id="2193130at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="225" mass="26290" checksum="D58EC95C32ED1090" modified="2013-03-06" version="1">MNKRTKSPQKILITFDPTTNKLTIRIMPIVQVNEEDMKLINGGIRVLNAFEWNKNILKSLFPKDMYGRIENVLIYKNKHGEYEEYWGKIKFYRNGNDEYVDETGFLRGELMNSLEEIVEKGRITDTGFFQSKDMSDEQLKESFHVMKVLIGEIARIKNKRIIDVMNEELRMTSLDKLIFVKNYKEKSTGPDGCVYVCECKNANCENGCEEIKCVDRAKLSELYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7K018</accession>
    <name>L7K018_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase, subunit L</fullName>
            <ecNumber evidence="6">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_0064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6"/>
    <dbReference type="EMBL" id="JH993803">
        <property type="protein sequence ID" value="ELQ76940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K018"/>
    <dbReference type="FunCoup" id="L7K018">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K018"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0064"/>
    <dbReference type="HOGENOM" id="CLU_090381_5_1_1"/>
    <dbReference type="InParanoid" id="L7K018"/>
    <dbReference type="OMA" id="QTHKVVI"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="5">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ76940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="103" mass="11797" checksum="19ECF078567C0E18" modified="2013-03-06" version="1">MNEHNQKYLHIKYSKNTPNTVELHINGESHTLGNLIAEKILSDPRCTFSAYKVNHPLDEEVDLKVSAQKDTPVLTLIKDNLKSLEDDIESLIAQAKEERKTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K082</accession>
    <name>L7K082_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K082"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0535"/>
    <dbReference type="HOGENOM" id="CLU_2814235_0_0_1"/>
    <dbReference type="InParanoid" id="L7K082"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="67" mass="7969" checksum="9C6BA10B682C75BD" modified="2013-03-06" version="1">MFSRNMNNIRYYGIFFSHLKYIILAILSTLPKLAKFRLNNRNKINVILKNHNLIYRSPPFSSVVFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7K090</accession>
    <name>L7K090_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ca2+/calmodulin-dependent protein phosphatase (Calcineurin subunit B), EF-Hand superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">THOM_0235</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993814">
        <property type="protein sequence ID" value="ELQ76796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K090"/>
    <dbReference type="FunCoup" id="L7K090">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0235"/>
    <dbReference type="HOGENOM" id="CLU_061288_10_3_1"/>
    <dbReference type="InParanoid" id="L7K090"/>
    <dbReference type="OMA" id="LKFAFRM"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ELQ76796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="196" mass="23407" checksum="F6FA415A1410C244" modified="2013-03-06" version="1">MGIFSDSMLCEEEIEDLTNSTIFSQKELELLYERFKMLDRQENGYLTYSDIMLIPEFCANPFNNRIINAMEKVIEYENMTFPFFLEIMSIFSPKSSIHLRMKFVFSVFDLNEDGRLCSAVLSKIYEIVHGNEFSRDICTREVDELLLFYDKKHKGFLDYNDFVNFYLDSNLDRMFVIDFDHDPIKKRPIFPFFRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0E6</accession>
    <name>L7K0E6_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0E6"/>
    <dbReference type="STRING" id="72359.L7K0E6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0054"/>
    <dbReference type="HOGENOM" id="CLU_1628215_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0E6"/>
    <dbReference type="OMA" id="GKLDEMY"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="163" mass="18845" checksum="70F4B2126170DC76" modified="2013-03-06" version="1">MFSIQPNNITVIHKIVSFNHPMRSSSHPAKQRFTNAQKIILGTFSHRVNDLMVLRLTTKDVPYPNTKVYAEKGVGTVDEIFGKLDEMYCSVRGLKDGTRFYVEENRFIPRARLDGGNGPVVNNKAKGKDKNKMKRTEVTFRRKNEQVVKGDGYNFRIRRKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0F1</accession>
    <name>L7K0F1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0F1"/>
    <dbReference type="STRING" id="72359.L7K0F1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0003"/>
    <dbReference type="HOGENOM" id="CLU_1441437_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0F1"/>
    <dbReference type="OMA" id="NDIHAVY"/>
    <dbReference type="OrthoDB" id="2194298at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF67">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="6">
        <location>
            <begin position="56"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="190" mass="21565" checksum="6A9A88EE51577EEF" modified="2013-03-06" version="1">MTLSSCVPVSNTIEKMRETFKVVDSDITHMEILNNDVTVSGCNYYSLFDYVPSHGVYLNDYINFYTCISNDIYNTWEVLGIEACRAVIIREVRAVFQAYGIEIDIRHLMLIADKMTVTGEYVAFNRHKMSGSVLGKMSFESTYNFLRKAYLYGSCDELEGPSARVALGLPVRNGTGMFDLLYEDNQGVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0K2</accession>
    <name>L7K0K2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993808">
        <property type="protein sequence ID" value="ELQ76877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0K2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0126"/>
    <dbReference type="HOGENOM" id="CLU_3360006_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0K2"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="36" mass="4211" checksum="7C6379A0EDDEB387" modified="2013-03-06" version="1">MLIGIGYENKDDLDMQEGILFEKEKFLKCVQETCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0L3</accession>
    <name>L7K0L3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">26S proteasome regulatory complex, subunit RPN10/PSMD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993804">
        <property type="protein sequence ID" value="ELQ76932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0L3"/>
    <dbReference type="STRING" id="72359.L7K0L3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0071"/>
    <dbReference type="HOGENOM" id="CLU_098733_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0L3"/>
    <dbReference type="OMA" id="QNQDYLP"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="47"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="248" mass="28540" checksum="A7DE66BBFD44DC54" modified="2013-03-06" version="1" fragment="single">VKCLTSDILWHRLAVLPAMHHHVIVIHPNHRFVFILPQTPPAMPDTTVFVLDNSYYAQNQDYLPTRYIVQLDIVNYALSSSSENHHFGVIPIAQQTPNYILTPTKNRMNIRQFISDLKFTEEFKIPDSIYIAQRSLQYVDATQKRLVVFFSAPVSDLTLEDVLMKLRDCAMMRCTVYVFLFGDAKDYKMFLDYELNDMGVIVTVVDAEENFKNKAMDVLAGSTLEEMEDPNLALALRLSAEEAEKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0L7</accession>
    <name>L7K0L7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993801">
        <property type="protein sequence ID" value="ELQ76952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0L7"/>
    <dbReference type="STRING" id="72359.L7K0L7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0050"/>
    <dbReference type="HOGENOM" id="CLU_1176127_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0L7"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ76952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="236" mass="26398" checksum="E30FB4B60D8683A6" modified="2013-03-06" version="1">MKEYDIVVYGASGFTARHIISHLQKYPLRIALSARTPSKISHNPKNYPVIQCDTNNLEIITSKAMVLLNCAGPYIRCGEAVVESCINNNCHYVDITGETTFINNIIKKFDEKAREKGVYVLNCCGFDSVPSDIGFDILKRKILGRINGDKQIADQGKEMDDKPSDASDSQAMTDVRVSSRNSVSGTSCISIYNFLRFKDVKCNFATFESLVYGLASYFDRPKQKNGKTGDRRHQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JQY8</accession>
    <name>L7JQY8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vesicle coat complex COPII, subunit SEC24/subunit SFB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_3229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JQY8"/>
    <dbReference type="FunCoup" id="L7JQY8">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JQY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3229"/>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="InParanoid" id="L7JQY8"/>
    <dbReference type="OMA" id="IMALPNV"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="3">
        <location>
            <begin position="130"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ73854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="712" mass="79613" checksum="9323FEF4CA768F08" modified="2013-03-06" version="1">MKMHNRTALYNSSFRCTANAITAAPTPLAVTFELAGTYKNTSTHVIRCTKCRGYISPYCEVLSPGEQWRCALCRHLNVVDTPFISRNGFLNNDAFNPLRNYAFNAENMCDERLTSLKLEMDASSAYLKQCSYVFVVECTADAYKRGVVSSVCNTLRANVHCLGSARVGVVFYAKTLCIVARGGALVVSDFEHLPLFNMDDILFDAQCMPELESTAEFLGRDASVHCDFGGVLRVVHAMLGTSGGSVVAFLSSVPNTGKASLAGQPASLRCKNEYYKTMAAAFSKCNISLSYYVFSCRNADLPSLSLLSRFTGGFLAYFPNFDANDRTFSCRLDEHVHAFLSGTKAYEGVLRVRGSNVQIVDYFGNFHLRASDVLSLCAVNFGHSITFGFKMNEGVAEQSTRNSAKDDLSAVNKILNEISENDACGLSCTDDELADDGGDKTAFVNNFLVGADDWVVFQVALMYSDERGSRRLRTNNFVVPVVKTRQAMVNEYAMAHFVFLKAINEEMGGKSGLDVVDRFVEQMAEEKCLGNMGRLMLSIKKSVVLRPVLYTPMDYRAFYVYLVLTSPLRLINRLIYPLLYDVATEERKELSLDSLEIDGFYVLDAGYNLFFFVGAGVDTNPEILELVNSCFADELTGRVLPKEYDNEYSKHLNSLVRRLRTGIRLVPNYYYIRDDGSNNVYKDIFFSYFYDDSGHNLESVGEYVKSIRRRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR15</accession>
    <name>L7JR15_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994100">
        <property type="protein sequence ID" value="ELQ73879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3254"/>
    <dbReference type="HOGENOM" id="CLU_3299689_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR15"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="40" mass="4542" checksum="A01D46F01F050B20" modified="2013-03-06" version="1">MMSTNQPDNLLYQLPNKITLTSREGTITSSAMQECKDYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR58</accession>
    <name>L7JR58_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR58"/>
    <dbReference type="STRING" id="72359.L7JR58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3154"/>
    <dbReference type="HOGENOM" id="CLU_438177_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR58"/>
    <dbReference type="OMA" id="EICACGI"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="624" mass="72554" checksum="CB7BD74CB7EDFAA3" modified="2013-03-06" version="1">MPMCYQEEKVAYIAREGTSELPETGTLKKTTALLNQIKQVREASLAKIIEDLSNIDLSNFLEDAVSSLLEHDGKNISTTMRIVFKLSSTYENFDDIFLNSFKEMLRKNLKTEGIDFYAVVYAEICACGIERRDKYKNFLRKTMEGNFYRHKLSVLHSIVSFLMEQINELEKMHGDHEEIVQALLSYYRSNLEYLKELYIRLDKSSGDQKHIKLLNSALGIEIQSENFVQIIELTEKEKSFYRNHKMPNHSKNEKTCRMTTEKIIQNIRDPYFVVCNLARNQRKEEFIMSLVNEPVELKYLAKIAAILNLDCTIEMIDMIHSHTNVSPKTLSELLIQVVKAERKIYFACELFKFDCFDRDKLIAMFHFLLKTKKYEILVNCLERAGRFLLAKEYSSNGNEDIIKLLLYLNTKSSEVGVGERRVIRNCLERIVRTNDEVDCADLRNFVEFLVGRYDIIENDRSVLKFGISEKLSELFQTNKLFLFTFLLDLWSFADPLKLAKVFVSFGFDIDLVPDCVSLCIEGEEKHKAVSYARLYGCMLRVSTMKNAELFAKIDSFVKKILFSCTGNEVCKIYLVCEFLSPFSASVKASFVNLMKDFVEMNDEKDLKIHFMNFCRINNIEIDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR68</accession>
    <name>L7JR68_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin ligase interacting with arginine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">THOM_3130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR68"/>
    <dbReference type="FunCoup" id="L7JR68">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JR68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3130"/>
    <dbReference type="HOGENOM" id="CLU_109009_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR68"/>
    <dbReference type="OMA" id="HRYRECK"/>
    <dbReference type="OrthoDB" id="2186115at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ73934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="258" mass="30520" checksum="5E4182375C51689D" modified="2013-03-06" version="1">MNLRKLTTATEKRRKTAQDTDEAPENEGTMRSLFDFAQKGAINLNAEKIVLFIKRCFDVRDKELLVKNFKEFISDENNKYEFLSLFYHSFESSDSEVSDNTESESAQLRYFADTRVCYGCGETGHVESKCPKRTQQICILCGYTDHPRFNCPQIVCTKCGLCGHRYRECKENVDRRKRYVICTKCPNKHTVPDCPLTWRRYKFDRLSKNSIRMSCCNCLRNDHFVDDCDIRRSKTSIFTGYYEQMIYQKRWNRGYKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JR99</accession>
    <name>L7JR99_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-finger CCCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994091">
        <property type="protein sequence ID" value="ELQ73998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JR99"/>
    <dbReference type="STRING" id="72359.L7JR99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3091"/>
    <dbReference type="HOGENOM" id="CLU_1251457_0_0_1"/>
    <dbReference type="InParanoid" id="L7JR99"/>
    <dbReference type="OMA" id="WEDMEGG"/>
    <dbReference type="OrthoDB" id="5395350at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041686">
        <property type="entry name" value="Znf-CCCH_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725:SF14">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725">
        <property type="entry name" value="ZN-FINGER, C-X8-C-X5-C-X3-H TYPE-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15663">
        <property type="entry name" value="zf-CCCH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-finger CCCH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ73998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="221" mass="26108" checksum="7A94A5D7DD900603" modified="2013-03-06" version="1">MDDCYYYLYSVCTKKNCTYRHSAAAKKNLIMCKTWANKRECRNECPLRHSDYHLRKDRKDIYCYWEDMEGGCQKEFCDFRHRNPEKDEWKKVKIRTLDEIKRKNSETHVPYGVQQHGSPCETLAAHVPSSQLSESEMQLIDGIRTDYTFEVNDFQNDRVSAKVFSPKGIKTHNRAERVNNGNSPLQLGNDEFTSKDIEKELEMIDKALEEEGLDMRKLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>L7JRE3</accession>
    <name>L7JRE3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_3045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994082">
        <property type="protein sequence ID" value="ELQ74043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JRE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3045"/>
    <dbReference type="HOGENOM" id="CLU_054444_0_0_1"/>
    <dbReference type="InParanoid" id="L7JRE3"/>
    <dbReference type="OrthoDB" id="10481630at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="274" mass="30544" checksum="CD516D817653DA33" modified="2013-03-06" version="1" fragment="single">VDKDEKKKAKKEDEGKEKKGRDKASITKPTPVTISRDKEASTSTSKDSERATKTISLIYTITKRQYIRQSVSALPSTSQMTMTVTSSLYKKFAQDETDTTKAIEGYLAKQSEGLTFNMSSEIAKISSKLSSCSIGTVSVIPVVPKPPKYVLSLDLPTKKNKKDIKMKKENKDSSDEKNKESKGKAKDEDEDKNKHSTKKSKLTTNEEEHGMLDVFNFLKKIPEDEIKGDSGKENDQTPAVFVSGALKTGTTKDKNELSNRKVKFWGFVQNLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS43</accession>
    <name>L7JS43_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2841"/>
    <dbReference type="HOGENOM" id="CLU_1195599_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS43"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="232" mass="26916" checksum="2EB65CC4B717D6E0" modified="2013-03-06" version="1">MFYIVVFLYLNTYMCTNISLYELPTLTCIQKGMVAGVKRSLDQSMVLLSTMADIETSDTCSTFKLSYSEITMYNLQLFRDICDLTLAHPNMTHFLEQAVHILKKFNASFIGCMFVKKRMQNIHPVPIDMHLIQSAEECVIQVEELLKKFIPALEVGISITMVPSVYLFDNLITFIKETCKLQDDLINQTYYEDFPRFIVLLTTLCEEYLNKVSILQLFLNAVRDFQQLCEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS56</accession>
    <name>L7JS56_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_2964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994073">
        <property type="protein sequence ID" value="ELQ74120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS56"/>
    <dbReference type="STRING" id="72359.L7JS56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2964"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="InParanoid" id="L7JS56"/>
    <dbReference type="OMA" id="CEGCPGQ"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF21">
        <property type="entry name" value="NUCLEOTIDE BINDING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ74120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="278" mass="30402" checksum="2DD9D3A8B1C144C5" modified="2013-03-06" version="1" fragment="single">PMLFISVVSGKGGVGKSTIAALIAAKLSKQAPTLLLDFDICGPSIGNIFPASGKVVKTRTGLKPLQVNNSSLYILSMSSLIKNDSSVIWRAPRKLQLYEMFYNSAYENILQNTTESDPDSYDILDKHNNIGNKTAQKNVTVDESCQLGYKYVVIDTPPGITIVHSFIKEKNTKILLVTTSQNVAISDSINTINFFGKISGIIENMSGLKCPNCKKITNIYSRNGGSQLAEEFNIPFYGTLEIDQNISQFIENGTLYENINSLGCNNVLDTVVRKLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JS57</accession>
    <name>L7JS57_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994099">
        <property type="protein sequence ID" value="ELQ73881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JS57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3198"/>
    <dbReference type="HOGENOM" id="CLU_2948400_0_0_1"/>
    <dbReference type="InParanoid" id="L7JS57"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ73881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="60" mass="6558" checksum="2355508FF454E88F" modified="2013-03-06" version="1" fragment="single">VCSDTIIDLGDLCDSLYREGSDNFDMFEEISELRDQVTSFSGGGGAQIHLDVNPAFWTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSA2</accession>
    <name>L7JSA2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Rho GTPase-activating protein domain, Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_3127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSA2"/>
    <dbReference type="STRING" id="72359.L7JSA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3127"/>
    <dbReference type="HOGENOM" id="CLU_381816_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSA2"/>
    <dbReference type="OMA" id="NIGSIMF"/>
    <dbReference type="OrthoDB" id="2196166at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="501"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ73931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="725" mass="83635" checksum="B366E41AC7E0E3F8" modified="2013-03-06" version="1">MKQVIQCKRKKFGLVVEEKLLSVSERIKQFNKLEMEKNDPKVYLERRRSVLGKYVVYEPDNNAGRVLDDECECSFCLKDLYYHFCKNFNRHYDNCQNIGSIMFCECYLIKLKKQHKLEQRIIEKVIEESEAPPEKETIEIESNEQDQYINDAIKNDMSTDGPENAKNVDFGVLEEKLVRQTQNNGYEQFMRLKVAQECRGSCCTECDALRAELGHKHFPICDKCFEPIVKSGEKSLCFCDGTFVKHNKSANESMKSFLDDLKVKLRIKNAERHKENNETEEETAGEGESDFIEEKKIDDVLNEKDEVQLAETLRDDGIVSIRESGEDAALRKELEDRDLINEENDVVQIDEPGENAEQTKDSGENDVVQIDESGEDAGQTNESGKDAEITSETQNAVDEERNTQNELNASTTERTGGSENEESNEEKTERSVIVDSSVHASAMSVCSAKNCVVRSSAYAKYNDLSYEEQYWLAVYCVRKIVKILPAKKRRVLNNLRKIETFLLGEKFSYFSKEHVHPFMFEVLAYFREHGVRVQGLFRLPGKLSIYNKMLQDLREGRRIVLKDYNIRDVASFFKAYIREDLNGIIVPSIIETIYECFTSDSYKIKDEVSQYLPFVFLGDRRELLMQILGLYKLLAANKDTTNMNITNLAICSAPSFFPKQVITDYQVVVKQIQVIENLFGLDYKHVPIKFIQRSKEFSREVEITESDEYDYGFSVLSAHETEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSL7</accession>
    <name>L7JSL7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2658"/>
    <dbReference type="HOGENOM" id="CLU_3020140_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSL7"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="56" mass="6838" checksum="83503EE2F5E92BF4" modified="2013-03-06" version="1" fragment="single">VEGVEQLKSSRHTKIHHCPLTWHLIVVDNWMKKEKTVHQNRWEFDTTHNLNYLVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSP7</accession>
    <name>L7JSP7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_2763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSP7"/>
    <dbReference type="FunCoup" id="L7JSP7">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JSP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2763"/>
    <dbReference type="HOGENOM" id="CLU_434904_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSP7"/>
    <dbReference type="OMA" id="SHTIMEM"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1004">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="155"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ74320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="628" mass="71834" checksum="D014AD6B01DCE909" modified="2013-03-06" version="1">MSNIKVLVRFRRPENSLPFTKITKNEVFVESNGVRYNFDRVFVKESNKSIYEYLRKGISCGNDLERAKIGNTDELADSTSLSNALTIMCYGSTGSGKTFTMLGNKHEKGIFQLIRDSYDIVEFKCFELYNERVILRTENVRDVGSFEGMLVRKRTALNEESSRSHTIMEMVVKQNRAVHEKHTDELFKIILIDLAGSEDNRKTGNTPQLNPSLMKESSTINKSLFVLRNVITAIYKKRKSVPFRESVLTKYLKEYFRGRVVLLATVVDDCDMMGEGISTLNFASMSKRIVWKAKMEHSQRCNEVVERLYRGKSSNGKERPVLDEKINFEDKGMRRPVRRVEKTKTRIKKDESDLKKKKTSGEKDGRGLNINSNGTNTKIGNGENIFITNGAFHNISCDIEGNSRGMKDDKTKNVLKDDADHVNENRMSDVFTTFSSNDMIIHSFDCKEEENDKLVSKKVFDAILKRALQFEERGYKRKALENYQMLLEMTEENKNGAVAASGDNSGQINSVIKNIIGDSFERDHSDSGKTVVDDKRKNDVGVLINRIKTKIASLTTARTKPSMITKKELLKLLNKADFLSLKKIKNIGDKRAMKIIEYLKFKRIDKTEDLCKIFSKRVVNSIMKNVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JSW0</accession>
    <name>L7JSW0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JSW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2476"/>
    <dbReference type="HOGENOM" id="CLU_545152_0_0_1"/>
    <dbReference type="InParanoid" id="L7JSW0"/>
    <dbReference type="OMA" id="AKTAFYC"/>
    <dbReference type="OrthoDB" id="2187767at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="462" mass="54385" checksum="298C333735F4EA39" modified="2013-03-06" version="1">MSTRIEVHALYIHNKLSAKNIEMDVNDIVEDLKTMKCKRMERLNDEEVYEKYLDHKTVHSKIFERIKNGEDVIYDMKLCLNRDIDGSVLQEYDVDSYLIYNNTLYIKFGNDFFDDSFDIKKVKRLVKYCDAYRTDEVYFNVEYRERNIILLVQILKKVNLPLKIVYYENCDNTVFLHMEDRKWPHDKQAIECVKSALLCHIYSHCKLSYGITREAVFLKLNDKIYKVMIKYEGSAVTCSLEKRNEHQEAHGSAVNDQSEKNLTDQLANSLRIYKTFGTGKKIAKEYIKLYLDSHGYFPFYIKNYEIDELIAEISAVNPGQIFIMFIKLPKQQFASLPGLDSMLLNRLVQLNAKVLEHLQQSVFIDGRRLLSPSLKDYDFVLMKENTEGQSERIIFVADNDRSKFLLGQVEVNDFFGMGTYAYLLYSEYNQVLMVKMKDMKYISLVMNVLLVKTSFSYVYKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT00</accession>
    <name>L7JT00_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994068">
        <property type="protein sequence ID" value="ELQ74151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2930"/>
    <dbReference type="HOGENOM" id="CLU_2694755_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT00"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="74" mass="8740" checksum="CFEFC28B3B89A216" modified="2013-03-06" version="1" fragment="single">VFDQRSMLDQRNVLDQSSVFDQRRELDQRSVLDLRSVLDLRRELDLRSVLGQVVCMKEIIKLIFKTSQKNVTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT10</accession>
    <name>L7JT10_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994040">
        <property type="protein sequence ID" value="ELQ74450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2630"/>
    <dbReference type="HOGENOM" id="CLU_1180922_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT10"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="235" mass="27456" checksum="1A3C8291C212AECC" modified="2013-03-06" version="1">MEYHPVTLEILRDYKNSPETDVSLEILTLIIDSKIFLDIDFIHKYILTYKKNIKNKKTAIKKLEHRIDAYFEHKVYKNIDDNIVCIERISAFASFVLPKNTCAILQLKNDSDISSLGLANRILRLIFVNRENAKRRLLSQLENDSQVLCPNILVNNEQRDGTEGIDKDVDKKRRNKNVTESICGLQTETKRDEELTTEDECFTKQKYLKMDVTAKKPKKTRTNEQEYKEMHGNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT54</accession>
    <name>L7JT54_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2523"/>
    <dbReference type="HOGENOM" id="CLU_1166548_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT54"/>
    <dbReference type="OMA" id="RSTYIAI"/>
    <dbReference type="OrthoDB" id="10490092at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="238" mass="27906" checksum="88538DA66FB24C16" modified="2013-03-06" version="1">MQSVKIERDFIFLIIIVLQCCLTMLVRSFFTKQTEVMLFEEYLMSLENPLTGIPKIVLVAIIIYFYLVKIRQDCQNFFVSLQENMLITVAMVIWFLLYATLLMFPVRSTYIAISYLCFRQNLLLFFEKLLLDTFLDVFLFVYLLFYKINGGKSIERIIRARNMRMSFYIQFLLAGVALLMTATHYYSEFDSSVALPVLYFMNSTLLLVCDVTNSVVFSYFLFVSGKMMATLLYPALIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT63</accession>
    <name>L7JT63_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994060">
        <property type="protein sequence ID" value="ELQ74211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT63"/>
    <dbReference type="STRING" id="72359.L7JT63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2862"/>
    <dbReference type="HOGENOM" id="CLU_1220438_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT63"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="227" mass="26766" checksum="BDC66D4B786DA949" modified="2013-03-06" version="1">MQITSNTIFQLNINSNKIIQHLINHYKKVILVIDDKNNTQFDHIYDFRGVNIHSSQVKDRQLITRHRFFFLVRRGLLSGLDYDCIIFRLPKLDSIEISTFKIFYYNNIKCKDLCAVFAFLGEINEMDPIYLHSKRFIMPNDTKPQESPNVKILVCKPTRDDELLTYLKLKTALEYNKDDDLEFISYELAFKKMVVYLKKNKHLIQQASCYSSTNVSEKGIRAIEHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT72</accession>
    <name>L7JT72_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994058">
        <property type="protein sequence ID" value="ELQ74226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2855"/>
    <dbReference type="HOGENOM" id="CLU_3263277_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT72"/>
    <dbReference type="OrthoDB" id="3353471at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5576" checksum="D842371FEB4A1D18" modified="2013-03-06" version="1" fragment="single">VYGQLYVALSRVCHADSLKVYITEDNGDQGKADNKMVYTKNVVYNELLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT88</accession>
    <name>L7JT88_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2453"/>
    <dbReference type="HOGENOM" id="CLU_2039705_0_0_1"/>
    <dbReference type="InParanoid" id="L7JT88"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979117" evidence="2">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="13162" checksum="CD1B4F42DBA33D4B" modified="2013-03-06" version="1">MHILFVLLHLLDTVTASYGRINENNLGQVNNSVNKNNTNSLPNLCLTFAFESVPSVSIMNTVQQLENGNLSCSSSKTPSTHKITSDNDKIGDDGSSYQPPVRIGRYRGSTKTCSVNLGIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTA7</accession>
    <name>L7JTA7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Shelterin complex subunit TPP1/Est3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_2810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH994055">
        <property type="protein sequence ID" value="ELQ74271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2810"/>
    <dbReference type="HOGENOM" id="CLU_401238_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTA7"/>
    <dbReference type="OrthoDB" id="10285852at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019437">
        <property type="entry name" value="TPP1/Est3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10341">
        <property type="entry name" value="TPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Shelterin complex subunit TPP1/Est3" evidence="8">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ74271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="686" mass="77432" checksum="72961659FC197934" modified="2013-03-06" version="1">MSSILKDNWIFNSLFSQLTTGKKRQTIHNHAQLLVILYNKPHKDIEVVLSDKHNTIIAELTQNAVTTYHQSFDHAFTDIKGCFVRIKRYAFVFCTSRKKFVMKVDLFEYEGNESEVVGNPSDVNLMSSIKEYTFMGVFDRMRYDDVGVGWSDVIGGLGGERKEYVERLIGSNGLVADGSDCCGEMVKHQPAVDPKTENMDGINNQGNDLISDVDGINNDVDGINNQGNDLNNQSNNLNRQRNDLINNKNVSISQGDVLINNKNNLIKALDQITSQIKNDSKTPLNHTQAIQNYKNVKSYNRLKHSFHGSKVNEKVIDFITKTELHEDEHADEHVKTGGNVDEHVKTGGNVEEHVKTGGNVDEHVKTVETVNELLNNNNLNNNLNNNLNISLNTKYVNTYVMPDLTAQQNNKDEHIAIDQNKWMNTYIKNSHAHVDNKDIHQPKNVNFNNQTNNTPPIHTVQPTITNVPIQEEKIAVFERIDHLQLDILNQSTFDDQNFTLIDEQSCTGTLQFISEVALRARQSKEPADENECGWFNGDASVVQCMNGNDGLERNRNAGSVRFVSNEGIDNNKNEGIGKDKSRDERHDSEGMVKDKSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXERLRMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTC6</accession>
    <name>L7JTC6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994052">
        <property type="protein sequence ID" value="ELQ74296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2785"/>
    <dbReference type="HOGENOM" id="CLU_2924362_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTC6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="61" mass="6401" checksum="AEBFA479FD0E2863" modified="2013-03-06" version="1">MTQPVNTGVSVVDLAVQDSVEALTLDDNGVKTDFDSAMPNGVLEETGNEISPSSEFGRRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTC7</accession>
    <name>L7JTC7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_3068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994086">
        <property type="protein sequence ID" value="ELQ74017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3068"/>
    <dbReference type="HOGENOM" id="CLU_3263277_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTC7"/>
    <dbReference type="OrthoDB" id="3353471at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="42" mass="4739" checksum="244CC595C1A9B5C5" modified="2013-03-06" version="1" fragment="single">VALTRVRHADGLRVYIADNGDQGEADNNIVYTRNVVYNEPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTD6</accession>
    <name>L7JTD6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994032">
        <property type="protein sequence ID" value="ELQ74659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2410"/>
    <dbReference type="HOGENOM" id="CLU_3242459_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTD6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="43" mass="5188" checksum="80C00A0391E86A30" modified="2013-03-06" version="1">MNEHRYIRYFVLESKEFSRPRHVFTYNKIAVESVNVTEVVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTF4</accession>
    <name>L7JTF4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994047">
        <property type="protein sequence ID" value="ELQ74326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2769"/>
    <dbReference type="HOGENOM" id="CLU_548120_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTF4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="498" mass="57066" checksum="251D07154C269811" modified="2013-03-06" version="1" fragment="single">VIVFFVYQPKHDHKTTANETPAEIDKPKNNNEYYEPNNINEVSSVLDLKNSTPIDSFAPYLINNTQRVSDRIEHGLSDYYTGIYDYNNSLYEYQNDLKHKQNRLGHYHHEEPPYDDSTDCNANYKFNNFCCTPKIENCPLKQDHIVEERKINQTNSDNFSKYEQLNVEKDENEKEYVNRTVKLKQKDSCHEKSPAKSNNENTELSNINKTLLDNEKVKGIEIMRNHIFPEYKRGLLNCDVSIPIDRTSFEQKKALLTTNIVINDSDESLHSKNDIKEACTTNTTNIFDFSNFLGISTTGDVNNTVDMVNVVDNGNTIMNKPIKYTEDKDTNISSAENSCNINNSNSQKNATDDSELNHYNETEISQEPNKNISGIENQKNEISVVSENNDGAEYVHPNKIAKTCNAQNNTTIKHSNEMMLEDLAHSDELKKPPSTCMSPLDNREMHKSLSLASKINENADKKASSYQKIRLMIMSAFCRIYHQPAITSRMMCIVPKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTF5</accession>
    <name>L7JTF5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">THOM_2524</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTF5"/>
    <dbReference type="FunCoup" id="L7JTF5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2524"/>
    <dbReference type="HOGENOM" id="CLU_489666_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTF5"/>
    <dbReference type="OMA" id="IVKCMHV"/>
    <dbReference type="OrthoDB" id="2192404at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="505"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="228"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ELQ74610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="557" mass="65450" checksum="E76626ED6DE4FA9C" modified="2013-03-06" version="1" fragment="single">VRQEISTILIKLFFYPPQHGSKRMNKRRKATIEMKRSKILKELVNIVEKEKIDVMQKKALVYEIELYKQKNNDLYEKYKELKNENELFYGVIAYLLKSGETEFVSSEFVDEQDAFYKRMIDYIVRYKSLRNKKSHSHKKNAAGAENDENECLDQHNDQIKKIIEQMEESVLLKYKEYVEEKDDIIYHLKRKVLDLNSSLANCGETAPQKAVDKVEKDVNVDELMEAVEASKSEKMGELYKEIEELKKKLLENAKVTGEGEDLSKKKIKDLEDVLKQVEERNCELLRDAQKNAVDFKEALDKMEKERDSYVKDLKQKLESANEVNGLLKEEIGDLEAELDVLKNKMLDEDARSGEELKLRKELNAYKNLKDVVELEKRENHREKERLAEDRESFEQLKNRLNYEVKCLRIELEGRNNAASYHKKNYLKTNAELLYVTERVQSLEKNEIVLREDIKHAQEQQVRLESKLRMLSDDISNYRTVFKALAGTSSPELIESLDKYRKLLRCSTCDKNYKDTVIVKCMHVLCRECVDGRLKMRSRKCPICGEGFSATDVKRIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTH1</accession>
    <name>L7JTH1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994030">
        <property type="protein sequence ID" value="ELQ74694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2381"/>
    <dbReference type="HOGENOM" id="CLU_1008969_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTH1"/>
    <dbReference type="OrthoDB" id="10600739at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="276" mass="31993" checksum="E1D7B70F9C8E6695" modified="2013-03-06" version="1">MPFFQLSYIHRLSSLAFSFYLDMLFDPDTAISTLAARYVHRLTKMYDITVSKHNLEHLFIVVTRCNDTVRKYIIKTIGNLVFDEQTIDCLSVCIGQLDIKYLIDCAEKVVGNNTELVKRAIKKWSDKKAEDEDKKENNIEMNEKDVNDLERMQNGSNKGNVKDQSENDVDEGITGDEQAYNEVVDHHDENSTRVVSEVDHVSDPLPVHTMNDNSSINRSLFKENNLGQSLFAFFLGPSNDYLQVFVQMNKHKSKNIQKRERDVCFEKIDHIFEGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTK3</accession>
    <name>L7JTK3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative FY-rich</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTK3"/>
    <dbReference type="STRING" id="72359.L7JTK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2270"/>
    <dbReference type="HOGENOM" id="CLU_1090704_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTK3"/>
    <dbReference type="OMA" id="YFIYPIN"/>
    <dbReference type="OrthoDB" id="2192852at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="255" mass="30453" checksum="B54565D5E77D0B54" modified="2013-03-06" version="1">MQNNLQKSEIDRLYEKFRALLLKKAELSAKINDEKTRKLKIEAKKRTILDFLRIIRAIKQHTSHNTTENAINDLRNILKHSGGLSMYDEYVAQCTEYEKLQKELRFRKLLSSMTFTKNPIIFDTRKEIFAILNIGVMPTAHQTDFYNRYFIYPINYRVERVFRGYRTDHSSLLVYTCVILNKDDKVVFEIYDNNKLLVSGGKSIWKNFCDLFKMNINDVKLEDFFALTNKNVQFMIEDSVDLKRYEQYIPLRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTK6</accession>
    <name>L7JTK6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994023">
        <property type="protein sequence ID" value="ELQ74798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2275"/>
    <dbReference type="HOGENOM" id="CLU_162138_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTK6"/>
    <dbReference type="OMA" id="PQEANFQ"/>
    <dbReference type="OrthoDB" id="2189011at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031495">
        <property type="entry name" value="DUF5100"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17029">
        <property type="entry name" value="DUF5100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="127" mass="15100" checksum="45F0508409AF54A3" modified="2013-03-06" version="1">MSNESKLQKILHILNSSANLENYIDMLESIDLVLNVNDDEKDYFMCPEEANLQLPNVFLRQTKLLECKHFIKSKANNRIGEHFYENCREILDFLESVELQEPEFMESKKKPDIDVNLLRELVKKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTU5</accession>
    <name>L7JTU5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2154"/>
    <dbReference type="HOGENOM" id="CLU_315724_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTU5"/>
    <dbReference type="OMA" id="VERICLN"/>
    <dbReference type="OrthoDB" id="10576183at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="925" mass="105709" checksum="F6966221F80C3320" modified="2013-03-06" version="1">MQISPNELFSPLVGVILFFTEQDVIDRSSYMVYNSVEAANLADCMSSKIDNSFILNQSKWYKSDEYGVLQNITTRTQGAGTDVNKEAMDQSGSTSSETNNQPKLKYVQIDMPISKVLYQTITDSSFSSSQLLTPDELSKIIMSNLFSVLDNRLTIIRVIVEHLYKEKQIYRRMYHDYIAKGYNILISINGFDMSENLYMSLINMESGNMILMQMLNGIKIKDDLVQHDAICKANLYLTSWERSFANLLREVKKSMMFQITDSQNQKAYASSDSTSLQIGISISVEDLNICYMFNKLSMNSRFLQSNKQLLKKQFDSADIRPRLVLEVAFDENEIVDQETELTVDKFINSDYFTNVALHFHNLNIELKVAEIGNTEYSMCLDNCGLKLFKSLPARLTRLEMKNMHLTESIQIPHTFDTFVCRDVLVDEGCEIILNRSNLKIELVGVQGRIRHDFGVIVSQASSTIICTRISNKRIELLKMVDICCQSKFICSNEIESLELIKAEMSGGRAIFSGNCKKILVVSCSNAFNFKTMRSVDTLRIAGNLSKDFFDNLPITIQTLIIKDAKMNFNAIFQKELICLRLENIQVKPQCKFEMTNECKSITITRSTGVFNLFERMNLIFDNQQDNLQEFILEKHDEDNLLDIRVAYAKMDAKNVVVENLKSITLKNVEIVEPLFLYIDNRLKKLEIHETTGKFEMNGIVTGTFKNVEETRLGILSIVNIANPNRYTIKIEKSMLLVAMSITCNLEHLKLDDITADKNFKVSVKGTCYHTELKKYTGSLEMLDIPRLKRMSFVRADVDYNMVTQHFSLDGKLHEQGCQVPRNINSLKLENLVMSNQRIPDRHINLEQINIKRCVGVFNFVGLLNIKDLDLKLKSVVEMKNITTIDAEVNLSHISFNQSLNFPNNISKLILTHVNFANGTNVEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTV0</accession>
    <name>L7JTV0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Metallo-hydrolase/oxidoreductase, Beta-lactamase-like protein</fullName>
            <ecNumber evidence="2">3.1.26.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.26.11" evidence="2"/>
    <dbReference type="EMBL" id="JH994015">
        <property type="protein sequence ID" value="ELQ74849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTV0"/>
    <dbReference type="STRING" id="72359.L7JTV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2210"/>
    <dbReference type="HOGENOM" id="CLU_044538_1_0_1"/>
    <dbReference type="InParanoid" id="L7JTV0"/>
    <dbReference type="OMA" id="CGPDFRQ"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="256" mass="28798" checksum="6DF1502612CD31E3" modified="2013-03-06" version="1" fragment="single">VLMAELIFLGTGPSSGIPSLKCRLAGSCKVCDTTTRTNVSIIINKGVSSILVDCGKHFYTQYNRYLSTYGNTIIPELLITHPHADAIGGIDTYLMMCTGKKNVYSSKFTLDFIRKTNEYYFVKPGDPEHRGYFHPNVLAHGQITQIGGIKVHAFEVDHGGIKSLAFLIDDKVLYISDTSDLHPIPEEFYHRDVLIIDCLTIDQHVRGHLNLQDVKRYASILQPGRVILTGLSHRIEQVDFLDGFRVAYDGMRFEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTW9</accession>
    <name>L7JTW9_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTW9"/>
    <dbReference type="FunCoup" id="L7JTW9">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JTW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2122"/>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="InParanoid" id="L7JTW9"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="6">
        <location>
            <begin position="139"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="266" mass="30495" checksum="7E099068DC9E8AF0" modified="2013-03-06" version="1">MFELKIIESDKDENSTQNRTSIFRKIVESAADIVDDVDIKLNDEGVSMQFMDAMNVAMMDVLLTKNMFDEYRCDRSLTLGLKIKEFSKILKGIKLDTGTTFYLHCDDNPDTLNMVFEGEAFVSNYDMKLQNIGSECYDIPQIDFTAEAEMKCSDFLYMRKAVGNFSEYIQMNACKTCINFSQKGEIIDSNMKFKAPETGKFDMKLNVTEDVWVEIPMKYINCITKTAGFCQTVKICLGNNAPVFFEFMVGDYGHIRYYIAPKISDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTY0</accession>
    <name>L7JTY0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diphthamide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994010">
        <property type="protein sequence ID" value="ELQ74879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTY0"/>
    <dbReference type="STRING" id="72359.L7JTY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2186"/>
    <dbReference type="HOGENOM" id="CLU_602970_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTY0"/>
    <dbReference type="OMA" id="CEMCELH"/>
    <dbReference type="OrthoDB" id="2193766at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="448" mass="51701" checksum="8D0F6BD7835982DF" modified="2013-03-06" version="1" fragment="single">VFKINFYTFPLNLNLIFTFLFDSPKFFFYRTALIIILHISPYKCPFGQLGSKILQSLGTHYMSTNTHHNVSIDTHSASTRTITSIKFNNSFNINTLDNIKPLNNQQIYIVPEYGNEDVAQVVYNSLRKYDPIILCSTKFACGLKYVKSGLYVILCEMCELHEFEYYTVLDDKCRRRIVVKEGNGRVFVDTANENIMRYYQMRYGTVSVGKSGDMKNSDSQLFMSNDDDDGENTAKCQENNESCDNAEIRVDQSDNVTNAADNVKDALNIIEEFDRVKFLISRLSRVQKAKDSTIFGIYFTNFKLEEFAYKIREYLISKGKKTYMYYLRDISYERLTCMDGIECVVIVDCHYHTLFDISISIPIVVPFELNLAFDDGEWDGMYDINTFSEARTDDNKCTGMVISDYYSTGDLIKRNEAQCVNFYVEQFDDKIYDGLDGIAGSYKQVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JTZ0</accession>
    <name>L7JTZ0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994009">
        <property type="protein sequence ID" value="ELQ74889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JTZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2176"/>
    <dbReference type="HOGENOM" id="CLU_013159_0_0_1"/>
    <dbReference type="InParanoid" id="L7JTZ0"/>
    <dbReference type="OMA" id="FYLTIAQ"/>
    <dbReference type="OrthoDB" id="2195965at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="776" mass="90941" checksum="495C0594C65145CD" modified="2013-03-06" version="1">MFDESDFDFNQVFLLVDLKYQQYSTFHIKMFFAGDYKLEILCSVGNLGGKALVRMPANNQKNKWELSFLEDPHFDVRVDAFVGHGSGIKQYFNCVFSLLVRRVLYHSLHRQLVFPNFHSLMIPMVSSSLKYVDHKISVFNEERYEEWSRNLSNRLFLYVSMNYRIMRKNESVTVRRSNAYINGESDRINLLEVDFRNCSAEQTSEIGDDGKQAGLKKDVYGGLYDNDIVVSCQESMPERSKETINKQQEEVIIDKIGNRIGTEDINAGNIARMSVDTPGFVHNVMKNIDIIDEIDNIKGGSQRIIDELKLITEMKSFDLNILSYFYNLSIFKYIQHDFLYLKVNRKFNERTSLVKLYFKKSVFDYIRIVRNNMILFQRNSINEPEFFIIRMEGTKLQIFYYLINPFFLFSFKKGHKIRECILNGKVIEEEPDIKVTELESRDTRNDIRKFKKMVDQKEGLVTKTVTFDISDKNLREILDDPIIRFRLMGMIVKIVDVQQISENTSLYIVKSREKPDEAIKIVSFSDDTRIIDAEVNMRCLICFFTIKQLNDGSQLEVNFSSSLETYLRRFFISPVMIKTKFYRPEFKPLVLNFTYDKSIEYKFRCDTGNIMFEMHSEIADDFYITVKIDKEILFDNLKIITTKKNRLIITITKVGEVKIHIRPKVAKKRKFYLTIAQTKKKVEEGENEFMMDIVTSLGMNRSIEPKIAVGKGNIIFWDLEYSENLIEMVSSKNYKSMISGFGILIGEDDVYKITVRNEGLKNKHIRFCIGSTMNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU08</accession>
    <name>L7JU08_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNARE protein TLG2/Syntaxin 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">THOM_2448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH994035">
        <property type="protein sequence ID" value="ELQ74536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU08"/>
    <dbReference type="FunCoup" id="L7JU08">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JU08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2448"/>
    <dbReference type="HOGENOM" id="CLU_093580_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU08"/>
    <dbReference type="OMA" id="EDTRPFQ"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ELQ74536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="260" mass="30844" checksum="FCDF73EF507BB96D" modified="2013-03-06" version="1">MLKDLTSKYLEKRNTPTAAFIPILLPIKIRESLDYTTKQLFNLKLLQERQCLPSFSKRKQKREEINKLKNEIRVLIVRLENYLKEINGLECTLVLKKRMKDYFAQNVHSLLVEYREMQQKYLRKVKNLQIFDDLEDTRPFQPNNNQSQQLICQKKQNDIESIRSSLYFITSVLLEMKAIIASHSNMIDRIDYLVDEANSNLRMANKEIEKIPSKYGGLKDRFIVVLLFITVCLLLLLVLKIYRKRLNLEKFVVINGRKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU26</accession>
    <name>L7JU26_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994057">
        <property type="protein sequence ID" value="ELQ74237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2849"/>
    <dbReference type="HOGENOM" id="CLU_2795746_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU26"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="68" mass="7696" checksum="57DB4DDBCB112434" modified="2013-03-06" version="1">MLFPLIPNGEMSQRMREFLASDGRTIGLLNLSIEFYFFATGWTRAKAAIAFEAFIFEALATPADRKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU33</accession>
    <name>L7JU33_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_2035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="JH993998">
        <property type="protein sequence ID" value="ELQ74993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU33"/>
    <dbReference type="STRING" id="72359.L7JU33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2035"/>
    <dbReference type="HOGENOM" id="CLU_397503_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU33"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="546"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="13">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="263"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="469"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ74993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="693" mass="79666" checksum="3C8D0A0303A9F5B8" modified="2013-03-06" version="1">MNGQEKEGEGTRKECSKETSNNYRESSKVECDSYRQSNKTINNSINVNDNFNDNVNDSVNIKKALLNGSNFKTTTKHQQPYNHWYTTKHENIEQQKTNCKEQHPPNLQTNDWSSPTNVKGQHPPKNHNNVTWQDSDDHLNTYNSPYGTTKYLRSGDEMSVAMRNSSSFGWWRSEGQCAYRSREGRNAVKGSFFDRWRGMENKNKWRRRYDGGRDFSGGGYSNDYSEGRDYNDYNSNDYKDYNGDSTMGYDVPYNNNTFNRSMQDMHCHVSPNDDNRHVSPNDDNRHVSPNDDNRHVSPNIQPPRNRKSPHNKKAHNKKQQNVQERVTPPRTVPRNKTISPNSKRIDERSAVKDARPYERTVLGTVLDEQRMNEDVSFVFDGERKECDGMVKGAEEQFNECEMEGCAVDVNDGIDDNDSINGIDDCINAKSINNLKSINNAKDISNLNNINNAKDLNSVKDLNSAKSINNLNSINNANPTPTNTNPTINDQEMLSDDDKPYRRERKVTPKQPRSNNHKRSKRALKNARKTRSRIKSVINKDVLLTTVSLECDYTYYFINTSRIHGNGLFASKPIPKGSMIIEYQGIKIGNMMADKLENEYQQNNINSIYLFRLDKDLIIDATVYGNKARFINHSCDPNAEARVTLHDKQRKLLIYALKDILVNQEITMYYNFSAEAGDEELRCNCGSSRCRKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-05-03" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU40</accession>
    <name>L7JU40_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="1">1.5.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JH994006">
        <property type="protein sequence ID" value="ELQ74939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2128"/>
    <dbReference type="HOGENOM" id="CLU_1173115_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU40"/>
    <dbReference type="OMA" id="NDEAVHC"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="237" mass="27160" checksum="3EF7FE9341079284" modified="2013-03-06" version="1" fragment="single">VTEDVNFKAQSLSKLLQKFKCLRNIKMRINFSNSIGKNVFNELLIPSLESLTIDSNALCKNFFKNAEKLCKLEDVDINWPTNFTADHIMTVLNGLTMLPELTELILDRISDAHEWQMLENCEDLSLLKIKAPIDFPLMMNVGSRLCQTLKDLFISLDISIIQSVRLIFIKLVLLSLEITSKNNDRSVNDEAVHCFMRNNFTKGINGTLEILTLQQSTSFDLTPLSRFYFPKINLYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JU62</accession>
    <name>L7JU62_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_2091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JU62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2091"/>
    <dbReference type="HOGENOM" id="CLU_814288_0_0_1"/>
    <dbReference type="InParanoid" id="L7JU62"/>
    <dbReference type="OMA" id="QIANEYT"/>
    <dbReference type="OrthoDB" id="2196354at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ74959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="341" mass="39364" checksum="9C7CC0DDBAFE763E" modified="2013-03-06" version="1">MNYVNHSKTDTGENEQPTNTRTDTQSANTKENTFNVPLTKLTLNDHLKVAECNLSLDADDSLIRDYESDNVILNNIYGLFECISRRLDDSNTEIYERLLFLLNVGKLEDAKQILRFRTCKSGRVERWCKSERMRCCVQELRALVEQTRAAHAECAALVNKVHENVRDSTYRMQEMNAVINTVCSHLGIERDELTLSIQQIANEYTTLKQNARIEFDNTNKNLAQENERLKSALKALKTENTEIRNELVILSNEFYKSKQLTKQTTQTLAKQKRIIDILQEKLTLTGRETNYTIVDDLRFRIALLRSRIDGEVDGEKKRRLVDSLVDYEKRLSDFLSVDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUA9</accession>
    <name>L7JUA9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994046">
        <property type="protein sequence ID" value="ELQ74332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUA9"/>
    <dbReference type="STRING" id="72359.L7JUA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2740"/>
    <dbReference type="HOGENOM" id="CLU_2122790_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUA9"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="114" mass="13119" checksum="91FCB07E633DD931" modified="2013-03-06" version="1">MEYQNDVETIENVEMGLNDDKITDSSEPDQLLCKRSKNTRENDKLNEVDSLQNTEAQVFLTDYDNLINLGQIIVMHQIGGYLPPDTHLPIFDKLYSKITTNDSLKTLFSAIFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUI1</accession>
    <name>L7JUI1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lectin VIP36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUI1"/>
    <dbReference type="STRING" id="72359.L7JUI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2650"/>
    <dbReference type="HOGENOM" id="CLU_1750993_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUI1"/>
    <dbReference type="OrthoDB" id="2194191at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="149" mass="16092" checksum="81849D72A654D36C" modified="2013-03-06" version="1">MLAGILLYVVSIMSFKKKIFRIQEKTSMFMPAVDDDGTSYRYDTFGDVVATTYSSADTYLKLGFNGGSSRAGMITKSPIDGKSFRIDVRLTIKKGTGSEGIAFWVGKDSTFEIGPVFGRKGVSGLLVAIVTKDDVPYIGLSLGDNGSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUI6</accession>
    <name>L7JUI6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994041">
        <property type="protein sequence ID" value="ELQ74422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2656"/>
    <dbReference type="HOGENOM" id="CLU_1628218_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUI6"/>
    <dbReference type="OMA" id="ENIRRMY"/>
    <dbReference type="OrthoDB" id="2190746at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="163" mass="18762" checksum="B04BBD9ED07C4EF8" modified="2013-03-06" version="1">MLHQPNVLHIVKKFYKIRLYLRNTNLIKVGVAKNVLFVSPISINSSLVYTLNEKLIFKEKIINSTNHLLAIEVKGIITQRQLVMVLKKCLPTVFNVKVIKKMNNEEKVRNMYIHIKQSLVNILGACKGKKVMDEIFEDQNDEENFESEIESGSGCILSDFEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUQ3</accession>
    <name>L7JUQ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993985">
        <property type="protein sequence ID" value="ELQ75183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1915"/>
    <dbReference type="HOGENOM" id="CLU_3088970_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUQ3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="52" mass="6155" checksum="0A1BFEEAC67A0BD1" modified="2013-03-06" version="1">MPRIVDGQWIYLNNDMIDTSSMSDVTDYIFPYCLEVIVLRNVEFKYSSPPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUQ4</accession>
    <name>L7JUQ4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993997">
        <property type="protein sequence ID" value="ELQ75050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2030"/>
    <dbReference type="HOGENOM" id="CLU_1310880_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUQ4"/>
    <dbReference type="OMA" id="QNIERSY"/>
    <dbReference type="OrthoDB" id="10425261at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="210" mass="24891" checksum="36BA1A921D71FB33" modified="2013-03-06" version="1">MTILYSCLVNGENCLLILPLREHGNKLFENDIKINEKLRNRIYFRKLFIDVMLSYSKEQNVLHYVPYDNLKRKKLFFSSYLTKMDQHRRDNSKYLLHSAIEFTNCVFQPSFFTKDSEFIMFCILNKSYIDIEIYQCTDEELVLNFYGSFYFKDELAIEYFSYTMDSLAEKVDASQIDEMIGNVIANGEKISMSLNNERNSYCIAIPPLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUQ8</accession>
    <name>L7JUQ8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993996">
        <property type="protein sequence ID" value="ELQ75055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1984"/>
    <dbReference type="HOGENOM" id="CLU_1264300_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUQ8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="219" mass="24519" checksum="40E8D273748E6075" modified="2013-03-06" version="1" fragment="single">MSVKKSGESSLTESENYVIVISSDSESTEPESSNYNNDYVPSTTESPAATVSTPSNMVLSHEQTNQKENTALCYTHPTYSTLPAVLCEQQEQLNVIQPSVNSNLSNIHLFSEMRDGETNQMLETSQVTTDSQPCIQVTEPISNPLEGTSQQVHTTPQDNTSTHSENGRRATPLRPKALYPHEVASRMYPEYFYNPLHIFATIYPDATYYGRQFYSCRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUR6</accession>
    <name>L7JUR6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994038">
        <property type="protein sequence ID" value="ELQ74512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2608"/>
    <dbReference type="HOGENOM" id="CLU_189354_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUR6"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="70" mass="7866" checksum="92EA039A11386181" modified="2013-03-06" version="1">MEEFLGVFLGGRCHASYDLCIKLVAEGAEYLSLVVKEHATLCKLVTDFLHEMKAIASLTNQKNMHVIQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV26</accession>
    <name>L7JV26_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994008">
        <property type="protein sequence ID" value="ELQ74896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2142"/>
    <dbReference type="HOGENOM" id="CLU_1280457_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV26"/>
    <dbReference type="OrthoDB" id="10550786at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="216" mass="24693" checksum="BC2E1EC653BC3464" modified="2013-03-06" version="1" fragment="single">VPITKCMLVEPEHFLSFLGMIVYAYFNSKNDYLKQYLTVFIQEFVLRNSKLVIGELFRIIEIIGSVSQIKIFLDQVLFWLMMVEENEISSLSEELLFNCLIYFIRKSSEIHKNSLQGSDSNSTSSKTANSNTKILMSNLISVFDFITKRITVNGRFCVKRTKQMIYCLGLIAKIGFSAKEKIHIGDLSEQLMIFNDNIPITASEIEEVNAKIAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV81</accession>
    <name>L7JV81_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">signal-recognition-particle GTPase</fullName>
            <ecNumber evidence="11">3.6.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Signal recognition particle 54 kDa protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_1720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="11"/>
    <dbReference type="EMBL" id="JH993971">
        <property type="protein sequence ID" value="ELQ75334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV81"/>
    <dbReference type="FunCoup" id="L7JV81">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JV81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1720"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="InParanoid" id="L7JV81"/>
    <dbReference type="OMA" id="MTIFVMD"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="13">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ75334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="468" mass="51766" checksum="91EAEAB98A42F145" modified="2013-03-06" version="1">MIFDLGKSINSTLQNLFKKDVTDQGIEAAIKEIIRQLIQNNVGTKCVTQLKINLDSKLKTEELKPGINKAKWVYNAIFDELVNLVDPKCEPYKVKRGKSQVIMFVGLQGAGKTTTVCKYANFYKKKGYKAGIVCADTFRAGAFDQIKQNALKINVPYFGSADPDPVKVASEGVEKFRKDKFEVILVDTSGRHTQENDLFNEMEEIVGAVKPENIVFVMDAGIGQSAEHQAMGFKEKVNLGSIILTKVDGAEKAGGAISSVAITGCPIEFIGNGEGMDDLDVFSPRRFINKILGKGDLEGLAEKIKDLKIDEREIVNKIKSGKYTLKDFNLQLQQLMSLGPLSKVMEMIPGMGNLPISDEGVLRKMVCIFDSMTEKELGSDGEILKKETTRVTRIAKGSGTRPELVLQLVAQFEMMSNLMKKLGNNQGFMNLLNADTSKMSASEKAKLKQQATGFLPKNVINQMEEYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV87</accession>
    <name>L7JV87_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ74652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JV87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2438"/>
    <dbReference type="HOGENOM" id="CLU_164198_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV87"/>
    <dbReference type="OMA" id="NPVENIH"/>
    <dbReference type="OrthoDB" id="10353812at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="Zn_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon 15" evidence="1">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="104" mass="11828" checksum="5A02DFEB8227C8AF" modified="2013-03-06" version="1">MPLEHTVKLETENPVENIHCPICSRMSKTTKLVKKTYITFLMIPLFCVKTSAPYIGCDKCKYGLGMEDVMICDNCRNVIIDDADRFCSRCGFKVREELGSGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV93</accession>
    <name>L7JV93_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_2105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994003">
        <property type="protein sequence ID" value="ELQ74971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2105"/>
    <dbReference type="HOGENOM" id="CLU_2051303_0_0_1"/>
    <dbReference type="InParanoid" id="L7JV93"/>
    <dbReference type="OrthoDB" id="10531096at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="120" mass="13632" checksum="CCA1E8454B57BEEB" modified="2013-03-06" version="1">MEKQDEIITTGINANSPDQKSAKETENVQKEESIVDERTDKAAIASYPIYSEVSNGTDQNLEKASTFRQVKENISNFFSGIFPGIKKFFKKLKDKLNKKSKKEVAGKSNERNSRRNRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JV97</accession>
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        <submittedName>
            <fullName evidence="2">40S ribosomal protein S12</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">THOM_2408</name>
    </gene>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
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                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ74657.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
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    </dbReference>
    <dbReference type="Pfam" id="PF01248">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="1">
        <location>
            <begin position="42"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ74657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="160" mass="18012" checksum="13E34295C2949D94" modified="2013-03-06" version="1">MSPFFTLRRVFSKIFFSNPRNKKMTEQVYAPIIDDTFTLKDAITQTLKISSSNNKLKCGIRQVTKCLLRKNAKMIFISKEIDDKYRRIVVGLAKKCSVPVVVIESGDELADMAQLGRTTLADVKKMPKCSAVAVTDFVKCSVGRTYIEQMMSKGKLGMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVF0</accession>
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        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1590</name>
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    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993958">
        <property type="protein sequence ID" value="ELQ75463.1"/>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1590"/>
    <dbReference type="HOGENOM" id="CLU_056990_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVF0"/>
    <dbReference type="Proteomes" id="UP000011185">
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="404" mass="47244" checksum="C3DD936F559D59F3" modified="2013-03-06" version="1">MLKNMKLLISENLLVVPPTIEILILLNTVITGSCTLPIHIHTVILREVRLADSYILKFNQECRKVRFYHCSGEYDLSGIQKLEVLGLVPELKGTLELKVCLPSLDNVRKLDIAYNLNEDCLEYCLARYINLESLTIRSIDYREKCLPYPRLSLVKDGVFNPSNMNAWLIQKMSEYELPREHLGNETANLLNIKMNIFMGELFTFNVKNKLKYLKLIGCSLSGRNMKMLKEFVNLQTLVIDSAFLGNEMIKNIPCQLETLEIMDRNIYKDLFINLRKLDWKTVQLLRKHKSIKHLVLDKSIMKYEHIFNCLPVKLESLKFKKFFGYGIGFHAQNKEKIIVKRLVLLLDDPNTNPIMVIDNNPMVRQYYQLFDLLQNYIDFTKLEDLALETPIKTVSLDRRTYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVS3</accession>
    <name>L7JVS3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_2224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH994016">
        <property type="protein sequence ID" value="ELQ74842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2224"/>
    <dbReference type="HOGENOM" id="CLU_2039704_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVS3"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ74842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="121" mass="14038" checksum="E9F30250E8083EFB" modified="2013-03-06" version="1">MGVEQVEMIMVLEVERVELIIEMEVERVEMIITIGVEQVEMIITIGVEQVEMITEMATEQIIDKETMIEVEQIIEMIEQITYKTAFQKENTPNNPPNHTESAHHYTIHHVGYSHHIQAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW09</accession>
    <name>L7JW09_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polo-like serine/threonine protein kinase</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
            <ecNumber evidence="7">2.7.11.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_1320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EC" id="2.7.11.21" evidence="7"/>
    <dbReference type="EMBL" id="JH993935">
        <property type="protein sequence ID" value="ELQ75648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW09"/>
    <dbReference type="STRING" id="72359.L7JW09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1320"/>
    <dbReference type="HOGENOM" id="CLU_000288_46_1_1"/>
    <dbReference type="InParanoid" id="L7JW09"/>
    <dbReference type="OMA" id="GAFAQCY"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ75648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="465" mass="53427" checksum="099A4568252AD306" modified="2013-03-06" version="1">MSKRIEYFLPLHSTITDPSTNKSYTLTKFLGKGAFAQCYATDDNLCLKILKRSELTSDRLREKLSTEICIQRSVTHPNIVKLHNTFSTDEHIVLVMELCDSTLSDLLKQNKRIRESHTRTFLRQIVSAMAYLHSVNVVHRDLKLSNILLKNFTVKVADFGLCALINNKNKRTTVCGTPNYIAPEIINKVAYSFECDLWSLGVMVYTMLVGTPPFQKKTAKEIYNTIKRNEYKIPENTLISEEAKDLIQRLLITDPHKRLSLKEIEKHPFFNKKESLINVVLNNLRAGTVSLVGGEHGSHADLSTGRSSSTPADTVIFCIYLSKLNGLGYKMRSNRHGIYFCNGDSAIRKSTTTFVFITASIENNKKVLRKEEYAMESIPERYRDYYERLVYFIRNFYPEEQINEYQFTFVVRVRRTKSGYLMGLWNNSLVFSVGNGVVVVWEGKYVECINCEYGSVRDKLIEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW32</accession>
    <name>L7JW32_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993981">
        <property type="protein sequence ID" value="ELQ75241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1864"/>
    <dbReference type="HOGENOM" id="CLU_3377388_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW32"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="34" mass="3967" checksum="CAF61DBB613A49CF" modified="2013-03-06" version="1">MNGGRRKVEDVEQHNEMLSRILFGKNKLGIQIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW47</accession>
    <name>L7JW47_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993944">
        <property type="protein sequence ID" value="ELQ75545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1503"/>
    <dbReference type="HOGENOM" id="CLU_2706553_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW47"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="73" mass="8092" checksum="28277466CB8792E5" modified="2013-03-06" version="1">MIASSMFDLPLPFRPVIAVKVQMLRVVLEIDLKFVIVSCFSSMGGNKKDWKMSEGLLTGINCAVKQDSCIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW53</accession>
    <name>L7JW53_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1767"/>
    <dbReference type="HOGENOM" id="CLU_3320320_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW53"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="39" mass="4845" checksum="3165722594750A72" modified="2013-03-06" version="1">MNNMINRAKLWEGKILLRKMKNEKIKWKKKKIEKVKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW75</accession>
    <name>L7JW75_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="6">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="6"/>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW75"/>
    <dbReference type="FunCoup" id="L7JW75">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JW75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1798"/>
    <dbReference type="HOGENOM" id="CLU_553883_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW75"/>
    <dbReference type="OMA" id="INEWDET"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="8">
        <location>
            <begin position="302"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="493" mass="55380" checksum="B8DC4DC02B0C340A" modified="2013-03-06" version="1" fragment="single">VVNGCSKGLAVMEEMITTASKGAVTACASHKEHDIESLSTFNQKKWPGNLRKDVHVLSILRRILEFLRIKLKSTHLTINTPHNFVCSLENLTFISRRTLSFLKKRFQAVKLPFDENVDKLNVLVDMMDTLARYAGSNAFSVIFEPLLSNNSLSPKITLSCNDSRIAMSALKFRSIMVTSGTLTPFDVYMRLLGITGRSVSIRGSTKEVLIVSKGNDQINISSDVSLESDKTAPARPSSDAVPITETYGSVRNAGLANDFESALLSSSYKLRTSSSTVRNYATLIKDLCDIVPDGMIIFFPSYVFMHEIISKCEFMIKKLHKLIFIETINYEESINALMNYKRAIKHGRGAIMFCVARGKVSEGIDFKNEEGRCVLLIGVPFAFTESVIIKERLKFLKQNINLNAFLQFDALRHALQCLGRVVRGKNDYGLMVMADYRYNSYKYGDEYDVIDGLSVDMCVNIGKAYFRKMANRELEKMLDEDAVLKLLEGEKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-12-14" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWI0</accession>
    <name>L7JWI0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993925">
        <property type="protein sequence ID" value="ELQ75774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1235"/>
    <dbReference type="HOGENOM" id="CLU_2442429_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWI0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="90" mass="9571" checksum="74E40D90AD64AB08" modified="2013-03-06" version="1">MKSRVLSKEAVVILSKEAAVILSKEAAVILSEEAAVILSKEAVVILSKEAAVILSEEAVVILSEDAAVYLNENGTIILLSVYALLVYLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWI6</accession>
    <name>L7JWI6_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar sorting protein VPS1, dynamin</fullName>
            <ecNumber evidence="6">3.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">THOM_1614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="6"/>
    <dbReference type="EMBL" id="JH993964">
        <property type="protein sequence ID" value="ELQ75421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWI6"/>
    <dbReference type="STRING" id="72359.L7JWI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1614"/>
    <dbReference type="HOGENOM" id="CLU_424641_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWI6"/>
    <dbReference type="OMA" id="YLIERVY"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ELQ75421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="645" mass="74347" checksum="E1EBB6F6DBBB6E3C" modified="2013-03-06" version="1">MPLPPHITKLIKLQQILQPTTRIELPQIIVIGPQSSGKSSVLERIIGHDLLPKGEDLVTRCPIVINLRNAGVNYWECNDKENMENGRGNTSELCESSVHSGSSTGNACGSIDSRKKGRNDRVTKEYAVFADSNDVYDLSLVKEELKRRMVVLCGNRKEISSQQIVVTLYLRKTVNITLVDLPGLTKVPVGAQPNEIEQIIDDLNMSYCKNNNSIILAVINGCVDLVNSESLKIARLCDPGYTRTMGVVTKLDLVDDRPSIHAILENTKIKLGLGYVGVINRNTKALYSVSVHEHAKREKGFFRTRFSAFYPRIGTQYLIERVYDTFKDKTKAFLDGLRDTLEIENSRLMELERNDITYFYRIVDEYVHHVCLKLRNEHTAGRLFSNDINLRAYARLADLHVTIEMKNVFLNEAQFMYYMRRKTDHLHVQIVSKIGKVCEAVKTYVESIRNGTELREHAEDEQHDTKGFFGFFSPVRFLTTKEQTNDESIIDNTDPFICVHDNDLRTRVIHGLNEAAVAMLGTQRAKFVQNIEQYFKIQQSYMDVDHPDFNTPMTGHSIFERKKDMLGMSLDLMTAYVNTYYGIIKKEVEHYFVKSIFFYFVDFFRNEFRMAMLRRSDEFRFVCENGEVRERIKENERLLDIIGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWM5</accession>
    <name>L7JWM5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_1602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH993959">
        <property type="protein sequence ID" value="ELQ75461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWM5"/>
    <dbReference type="FunCoup" id="L7JWM5">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JWM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1602"/>
    <dbReference type="HOGENOM" id="CLU_009308_0_1_1"/>
    <dbReference type="InParanoid" id="L7JWM5"/>
    <dbReference type="OMA" id="DNDHMGV"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="856"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="VTC" evidence="8">
        <location>
            <begin position="203"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="847"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="506"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="736"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ75461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="108773" checksum="299FE609D8DEEEE2" modified="2013-03-06" version="1">MNFHKYYKRNVYVPYEQHYLNYEMLVGSSDIDETAHSEMERVFKFVSERKEELAVWAKALEKELLMRINALDGGTDAEDDGLSYTNLKDILANPSRGYKKQLKRELRLFNKKLDLLRENVAILTKFIKVNIVGFKIALKQRNVYRTYRGRLAGYRRSVADVDRVMYAVSRLILRYRKRSASVIGLVSKSEGKKSKPSNSAFVRRTAKYWVHPDNIDDLKACILRHLPVYIFNPNDENYDSWTKEHDSAITSIYYDNASFEAYNTRLHKLQGSEAIRIRWYKLDEPKVVFVERKRHEDGWTGYQSKKLRFKIPVEHVNAYVNGQNVWKHVEPLNENKLSTLNLYNEIQHSIVYKKLRPSVRTFYRRMAFQMPESNNIRLSLDTDLVMIKENVGDSSAPFNWRREGINWPFDNLRPDEICRFPYGILEVKTQDDQKIWINEYEHLIEHVHKFSKFMHGTAVLYNTEMIPYWLPQMSIGIQKESFKSPPRKRYEFRDGELVEIPLIDQQDGDRERKAELSVRSGNDRSIRLDNDRDVRPGHDRNMRLDNDHMGVGPDNDRMGVGLDNDHMGVGLDNDHMGVGPDNDRIGVRRTNEVDRASLRYNANNINHTGVGRTGHSNTRTRSADINNINERLINNEITVKPSQASLRHINDEITDGQSISRISVVRSDEYSQENRQTAGVSSSNCMHCVPSVSYAPVRSNRTINEDMQVPERITYGECVHEQMGLTRTEGSCVAGGSESMLGDSHRNTSGESLHRSVGLKVPSRHGSAGRNTSTERDQPVYSGHGSAGRNTSTEREQPVYTQRSTDKYQRAPKHMVSAQREDDESTKSVLVPIDNKRIAIPVRVEPKVFFANERTFLSWLHFSIFIGGLGSAMVGLGDYKALISGAVFIVVSTIFAVYALYLYMWRAHKIRARNPGPYDDLIGPGVLVFVFIAAMALSLLFKMPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWP4</accession>
    <name>L7JWP4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993916">
        <property type="protein sequence ID" value="ELQ75849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1191"/>
    <dbReference type="HOGENOM" id="CLU_1541191_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWP4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="174" mass="19527" checksum="A6299CD6F9606703" modified="2013-03-06" version="1">MYRLFILVAHMVAAINNSTEDKNATQTDGRNTNDESIPSTYMNNNAEVKAPSLSSVPSKNYIFHEEKSAPLPGKYSSVTKADKRLNNSIQQEEKNNIVEKTNETKVECCSNPCNITETQIEDSGINREAIEIPDSLLEVKLSWDDYMVSEPKNCATTNTNEHITTPQKKFTAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWR8</accession>
    <name>L7JWR8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH993910">
        <property type="protein sequence ID" value="ELQ75874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWR8"/>
    <dbReference type="STRING" id="72359.L7JWR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1169"/>
    <dbReference type="HOGENOM" id="CLU_721958_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWR8"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="383" mass="44983" checksum="2D2D83A296DA2D07" modified="2013-03-06" version="1">MKIMLEWAGDIALKKFTNTKINPFAFKNLKFRELYSDIDKKTDIFVILDENMSSPFTNRIVQDLNDEGNVLVVFNEEHEHTIRKLDYIDTPDFKVVKENDNKIDKSQGAQHKKNEPDPENTEEEKMHRVVCKKGHGDGAPTFPLKDKPRPRDRYGEFFDKKLFLIKAEEKRKEVVVEKPSIKKTQEMITVNKVPFSCRIRTKYFNFNGLSDGNSVKTILESLEIEKLILLGKNKSFINFFYFLCHYNQNFREIYVLDEQILNLSTDVTTTKVNLEENFLQKADLREINGKQMASFKGRIKDNVLYYRESLKESLCLGTVKMTELRKQLLDNNLRVKKADEYTLVIEDQVKVQFNDGAVKMVGEMNGVYLYVRRIIYKNLYFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWT4</accession>
    <name>L7JWT4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase, LTR Retrotransposon</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="JH993951">
        <property type="protein sequence ID" value="ELQ75526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWT4"/>
    <dbReference type="STRING" id="72359.L7JWT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1517"/>
    <dbReference type="HOGENOM" id="CLU_1055845_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWT4"/>
    <dbReference type="OrthoDB" id="425619at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="133"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="265" mass="31331" checksum="6ED2E0A92ED7D2DF" modified="2013-03-06" version="1" fragment="single">NFRIEYSKPVNLVEVDALSRTHEKAKEPTEINKRAMKRYETINKKHLCTVDGKKHWRLDSGIVREVPEKENAEKLVIEAHLKTNHRGLEPICYEPKERYYWLGMKRHITEIIKRCETCQRNNRKYTGRNEMVATTRPIEKVTIDIAKIKGKTVMISVDYFSRRIWVRDVGNRRKETIIEKMNELVEEWGVPEMIITDNVKEFVAIETKNWMTEAQIVHEKTNAELYKSNGRVERVIRTVREGIEKMGVNEMGKAIKEVEDKYNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWX5</accession>
    <name>L7JWX5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Paf1/RNA polymerase II complex, RTF1 component (Involved in regulation of TATA box-binding protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWX5"/>
    <dbReference type="STRING" id="72359.L7JWX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1494"/>
    <dbReference type="HOGENOM" id="CLU_078876_0_0_1"/>
    <dbReference type="InParanoid" id="L7JWX5"/>
    <dbReference type="OMA" id="MEHRIDE"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plus3" evidence="2">
        <location>
            <begin position="81"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="303" mass="35717" checksum="E6AEEDB5F1EAB5CB" modified="2013-03-06" version="1">MGDMQYNDMNLYQDSEDEEKLMKLPEAQREAILYNRYMKIKKLEEKKEVEHRIDELHEQGTKEHGTAVQEECITYDMLCDVLVPRTLLAKNVYRPAIDRLVGNFVRVCFKSGYVVKRVEGMQRASEYFVEESTKNYRTNKNICIVRGSGARECIPMSFISNSRPSFAEYDHFKMSYPDLCVAALVKKAHAFKNAMTREMSADERARAQEERSKFYRDKRKNLMEKIRLIREREDAFKNGDAEKVRAVQKRIDEIDEKDKDPAEEKEKEIWDRINAKNRRINYEKGVRAGLEKARNKDSAGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>L7JWZ2</accession>
    <name>L7JWZ2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_1225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993920">
        <property type="protein sequence ID" value="ELQ75820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JWZ2"/>
    <dbReference type="STRING" id="72359.L7JWZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1225"/>
    <dbReference type="HOGENOM" id="CLU_010194_47_12_1"/>
    <dbReference type="InParanoid" id="L7JWZ2"/>
    <dbReference type="OMA" id="GVDTRMM"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ75820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="111" mass="11666" checksum="CCCF174AE1C7AB2F" modified="2013-03-06" version="1" fragment="single">VGSVFGHKVTDPNLVDLNYSKSGIHTLTKSMALGCASLGIRVNEVCPGFIKTPMLETVLGSDQYDHIVNGIPMQKIGDGDDVANAICFLLSDDARYITGASVVVDGGYSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX30</accession>
    <name>L7JX30_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1784"/>
    <dbReference type="HOGENOM" id="CLU_1448610_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX30"/>
    <dbReference type="OMA" id="MNIYNDI"/>
    <dbReference type="OrthoDB" id="2188144at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978936" description="GOLD domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="192" mass="22280" checksum="EF83C5D3FB48DA9E" modified="2013-03-06" version="1">MNALFSFLLCISSIFCLNYDLIFEKGETETFWEQLESNDYQLTVELSVTSPENAALRYRIIEPNSSKRFATYQDVSARSAPAKFTGKGLYAIEIFNFDSKPVLFSLSTYVDKEVEVDENTTYIKNILEKLKLDLRNLYNSSMQLSVDKRNIIRDARKSRTKLIWLCILPLGYVAVGIVKYRMMKSMFTPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX64</accession>
    <name>L7JX64_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993888">
        <property type="protein sequence ID" value="ELQ76019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1017"/>
    <dbReference type="HOGENOM" id="CLU_1157141_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX64"/>
    <dbReference type="OMA" id="HRRMFAV"/>
    <dbReference type="OrthoDB" id="10434280at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="240" mass="28426" checksum="85F5C7039F24A4DE" modified="2013-03-06" version="1">MTYDHESENDLDKLLVESDVLKTGKLRDKTNVAGRQSDLKKGAAQDRQVILEGLDEYENDPELARAFKKIDVQLRREHAIEKGPQVNARNYASRNYEGTKDTFGVKTDLDETQKRQSFYGVGRHPKGTFDLKERLDVDRKADNVQNYMQIQMELDRLRETHRRMFAVKGKIYQAVEKEMAKFKNELKEKTDLEIRRKDEEINRINGELEALKKEYNAVKDERDKFRTVYFKLKEKYKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JX66</accession>
    <name>L7JX66_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993937">
        <property type="protein sequence ID" value="ELQ75641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JX66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1412"/>
    <dbReference type="HOGENOM" id="CLU_3034053_0_0_1"/>
    <dbReference type="InParanoid" id="L7JX66"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="55" mass="6625" checksum="EA0059ED2437C012" modified="2013-03-06" version="1">MPIKTHCNGSKTYLRLIFTRRKVILRLRCLAIYDQLKNKDRSSSYVLKEKNNRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXG5</accession>
    <name>L7JXG5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993933">
        <property type="protein sequence ID" value="ELQ75726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1319"/>
    <dbReference type="HOGENOM" id="CLU_2190374_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXG5"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="109" mass="12227" checksum="CBCB0AFEDBA38279" modified="2013-03-06" version="1" fragment="single">VLYTNDTSTIGMFHCNAQMYFSVNVGLCTSTYDVDVVSVVAKVYCFGMIVDMSACSVGVMPDNVSVVCDGMLLWIDRGSVIGRVARCKYPMVYDLLVWRERADWYVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXN1</accession>
    <name>L7JXN1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="3">4.1.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA photolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">THOM_1560</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).</text>
            <dbReference type="EC" id="4.1.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="3"/>
    <dbReference type="EMBL" id="JH993952">
        <property type="protein sequence ID" value="ELQ75517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXN1"/>
    <dbReference type="STRING" id="72359.L7JXN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1560"/>
    <dbReference type="HOGENOM" id="CLU_407219_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXN1"/>
    <dbReference type="OMA" id="AHNIVPY"/>
    <dbReference type="OrthoDB" id="496749at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000002">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052219">
        <property type="entry name" value="Photolyase_Class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211:SF0">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="14">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="195"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ELQ75517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="651" mass="75013" checksum="8B0A10D2262268E9" modified="2013-03-06" version="1">MLNHRIEELHRIQHKPKIVLYLSRRDKRIHDNAALFYCYTLTDRVIFGIKPEYIVGNYMQRRFIAEGLAELKGACRQHNIPFVLIQRIDELVRTHCIDCIVVDHSPLRYSRAVDDQLYRYCKSNCIALVRVDAHNIVPYAVVKDDVKSSSAVKKRLLERFGEFVDERYLVERRECMWMSDDGMNDLEGVEVRIRDNLEDEDYEANEDGGDGEIEGEEDGGKEKEDVENDEDGGEGYEANEDGGEEEIEGEDEHDKNEHEDEHEDEHDDEHDDEHDDEEDENNVKSDNNGDNTERIGGGQTKKRKGETTKSTAEHGGANKKGREEGKRVKMDKKMKTMKTRAKMYRAQIKQIIQKHDLYSQYTPRLTGGYSNACCTLSTFIQNNLPIYDKYRNSADRDVQSSVSAYVNDGQISAGDVVRAVIQWGDDKHEDTRKSVKNTKNTKNTKNTKNTKNTKNTRKRNTGVVQEMAGGTGQNDAKSVNVTTYLNEIFVWRETAEYFILRNPNYDNFYGALKWAQDTLTAHLSDQRQHYTLDQLILARTSDPEWNAGQKQMVITGKMHGYVRMYWAKTMLYWFDRPEDAVTVGCLLNDTFSLDGNDGNGYLGIMWCMVGSMDQGFAEKSVVGKIRSMKGIKAKDYVRRWECYQLGRPNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXZ4</accession>
    <name>L7JXZ4_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">THOM_1433</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="43"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1433"/>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="Sua5_C"/>
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    </dbReference>
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        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="15">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
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        <location>
            <position position="54"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
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        </location>
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        </ligand>
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        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="117"/>
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        </ligand>
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        </location>
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        </location>
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        </ligand>
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        </location>
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        </ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="349" mass="38724" checksum="0286EFD465A15B0C" modified="2013-03-06" version="1">MLTVIKRLDDLTPEQLITYIDRHPIAIPTETVYGLASKISNTSTLRNIYTIKNRPADNPLIVHVSSVSMLESLVKEVPPIYRALIEQYWPGPLTLLFLKKECVNDIVTCGSKYVGIRMPSSKCARDIIDITGPLAAPSANISGNISPSHAQHVYKDLMGKIELIVDDGPCKHGLESTIFTCYGGGNGAVLRPGSITHEMIEMVVGGKVRMGGCEMVPGKKYRHYAPTVPFLLFDSDEQMIDWMRKCAGSAVYDDENSINRADNTTANHNSARADLGVLVTSDAIRNYVVSRNIRHIDLERTKQQISSRLYHGLRTLDKECARICMVRMDTKDEGMAIMDRVCRAAGQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY14</accession>
    <name>L7JY14_TRAHO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993898">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="421" mass="48219" checksum="482FCEF5408E0580" modified="2013-03-06" version="1" fragment="single">VLFIKYHNLICSYNDHTCSFIPIHYTSQPNPSHTLTFISLQTIIFLEPIPYIPTMPFHPKNTFIDTSAIPSPLSNDPIDHIQKHVITRRKKKRRILGTYRPFKSMYDEDIRFLTPRQQLRVMKYLSAKEKFLKTGRIVKGYYFDKDELLNVRRNGGNEEGKENGEVVGDCNNDVNDLKSNGENIVVKNSDGNSNEEGKENGEAVGDCNNDVNDLKSDGENIVVKNNDGNSNEKAGAIEYDDVRTNEKKCTKHAAKGKYNYKKCVMHNNKPQSASNIEQNEHTPKNINHTKKGKVCTRNSHGIKNKKVLGTKLLRTNGTSPTVNALSASHHVLKAQTRCKLQQNKYSGSLSFDYRHIARTYLFENGVSYDDKTQFIIQIKKLHSCSFRSFVECMEIALFRGNKSKKIFDDILRRFIKLECCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY20</accession>
    <name>L7JY20_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0676</name>
    </gene>
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        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0676"/>
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    <dbReference type="InParanoid" id="L7JY20"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003978874" evidence="2">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="205" mass="24059" checksum="DCC3F1F03494EC27" modified="2013-03-06" version="1">MVFFLLLLFAFSIDLENTLNELFSDNRWKNLLKEINKELKNGKFVEQTDKNTEELNKSEIIAPEMAKDSWHADKKECDKRNGTQKNEKNKAKDDESENVNKKLFSLLNFDSLDDEKSGDGEKGVINGGEKKEETIGDATVRKDTDDKKEEEEQRKRNGEVTTTQESNATRENNRNEEERKKKVKEENRQIKKTRITMRTKNVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY65</accession>
    <name>L7JY65_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993853">
        <property type="protein sequence ID" value="ELQ76379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY65"/>
    <dbReference type="STRING" id="72359.L7JY65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0635"/>
    <dbReference type="HOGENOM" id="CLU_407697_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY65"/>
    <dbReference type="OMA" id="NAVESIW"/>
    <dbReference type="OrthoDB" id="2196090at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="835" mass="98006" checksum="78BE30FC5AAE07E5" modified="2013-03-06" version="1">MDAEKDVNNKIKELLDYTNEYKNQEENKDLKHTKGTFEASTCDNINNNDQGTSEVQKLIEVLDRNEKLYSKINAYLNSSNHDKLQNELLKENINSSLVCESMMKVLREISAERNESVQNEKNTKMRVNELLKEQFDQKKKIVKLMDDLKYCSSANNELLRLVQDQKGRISAYKEKYELEKKNVLNMKVVNEELDSLRRKALTKIEVLTKEISVLSDRIKECNAQITALKQHEQQKEEIERSFESQVLEMERSLNEHKKVLEEKGKALEMCNSELAKLLAMEKRMKEEIKNLKEKSSYYERLYRSINEQNEYLNAQLTKFINNSEMDAFDRSDETLHSFGVDEKKKMATQDRDNGVGRDRTVNNEQFRGRLRKYKKKMRKYKKLFNVQNEQIAALKNNLSRADEQFHELQSEFLDLRRFNDENVGRKKSVTDDLLSKMKELMDRNLEYQNKIIQLESRRSRRKEDEKWFNVEKKLSDANLESINHRNRRVNDDEWMIGRGSNVKEGRNLKEVSDGEFKDFTESSPHISKPVMKEQFKSAIESSQYTAKPETKDSFKDEWKRFFDEAERQRNMRVEDDARDIPHKTTFYDAEGEADGTTIYTKNKNAVESIWNKITTTFKPNTRTNTETVQEKMEKLKMSTNEKRQEEFFDAPSRNETVSNEENVNDDQKGGKGGEQPENVYKHEEELKWADARDDMNYASQKVRGTPQNLVSPLIEKRSSDLVRADVNNTIVKPEKDDANKINKTAAINKKSTEARPVVGEHKEASTDSDSTTDTFKKMREKTQKLQQKFSELEQKLNKIKGNNDPSSKKLHDQIEAYTNYYYTDFVDISNDSDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY95</accession>
    <name>L7JY95_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993846">
        <property type="protein sequence ID" value="ELQ76443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0552"/>
    <dbReference type="HOGENOM" id="CLU_3144009_0_0_1"/>
    <dbReference type="InParanoid" id="L7JY95"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="49" mass="5592" checksum="D3788ADE770B8B04" modified="2013-03-06" version="1">MGSIYKFDNKEYTQKITGPDNNDIHVNNEQKVHKTTKKDIGNVLKDNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYB7</accession>
    <name>L7JYB7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glycine hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">THOM_0980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JH993886">
        <property type="protein sequence ID" value="ELQ76046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYB7"/>
    <dbReference type="FunCoup" id="L7JYB7">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0980"/>
    <dbReference type="HOGENOM" id="CLU_022477_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYB7"/>
    <dbReference type="OMA" id="TQPFFSQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="8">
        <location>
            <begin position="10"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ELQ76046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="438" mass="49576" checksum="4D35CF95EDE1D016" modified="2013-03-06" version="1">MNDPMYGNMKNSDHTLYRLIANENKRQEEFIELIASESYVSVSVLQASASLLHNSYGQGTLDENKNDRTSVVDKIEDLCKERALQFFNLDRNVWGVDVRPYSGTVANFEIYDALLGWKGRLMGMDLFCGGHFSHGFKTNRRKVSASAEYFESYFYGLKEDGRIDYEKMQKDLIENKVQLLIGGASAYPGDFDYKRMREIADQNNAYLMADISHVSAIIACGMMNNPFEYCDVAITTVQKMLRGPKAAIIYYRKDKNGVNVEKLITNSVSPGFQRSIRYHTIAGIATALKLTQAEEYRTFVTQVLINMQSMCGVFRENGVRLLTGGTINHLALLDMRSISFKGRVLKIDAALFEWICDVVNISVNKNTWPGDTSALHPSGVRVSTVSVTIRGFKEKECAQVASFLIDIIKRVGDFELENVNEIKQRVMSDDWFAGMRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYE8</accession>
    <name>L7JYE8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LTR Retrotransposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993878">
        <property type="protein sequence ID" value="ELQ76076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYE8"/>
    <dbReference type="STRING" id="72359.L7JYE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0952"/>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="InParanoid" id="L7JYE8"/>
    <dbReference type="OMA" id="EYCGHIV"/>
    <dbReference type="OrthoDB" id="2195789at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="107" mass="12732" checksum="32C35D43C7DCD835" modified="2013-03-06" version="1">MSFGLVNAPFTFQRIMNYVFKEFLWKSMIIYMDDILLVSKNKEEHENHLSKVLERIGKVGFRVNLTRCKFFKTRIKYLGFEIENSKIAIGQEQREKVASLKVPKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYF7</accession>
    <name>L7JYF7_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_1295</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JH993928">
        <property type="protein sequence ID" value="ELQ75767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYF7"/>
    <dbReference type="FunCoup" id="L7JYF7">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1295"/>
    <dbReference type="HOGENOM" id="CLU_006406_4_0_1"/>
    <dbReference type="InParanoid" id="L7JYF7"/>
    <dbReference type="OMA" id="YLTRDIC"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="290"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ75767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="403" mass="45760" checksum="38908F5DF38249D2" modified="2013-03-06" version="1" fragment="single">VYIKINRDLKEEKEAIEKQLASDMDEMGIKGPSQNEKSHTGDEKRKISKIDQEAKDYFTALERGDEEKMKQWRRFRSLSIEKYKTLYSTLNIKFDVYGGESLYAKAGLEVITDAEVDVDGSMFYDLGELGKFVVLKNDGSTLYSTRDLAAAEDRIKTYNPVKLVYVVASQQDLYFKQLFSVLKGECGNKKRIPDNVELEHIGFGMVNGLSTRKGNLVFLEDIIDAAKEAMHSTMIKNQAKYEEIENVEDTCTTLAVSAMIIQDFSAKRKINYTFDMKRNTSSEGETGPYLQYTHCRLMSIRKKNSSLCAKMDASLLSEEALSLIFYLSKFGTAVIDSYTTAEPCKLVTYLMKLSKQVNALFSTLRVFGEEEKLAQARLAVFEAARKVLNNGMKIFGMKPLERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYN5</accession>
    <name>L7JYN5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding SAP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993839">
        <property type="protein sequence ID" value="ELQ76544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0472"/>
    <dbReference type="HOGENOM" id="CLU_460919_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYN5"/>
    <dbReference type="OMA" id="ECNSAEM"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="530"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="592" mass="65239" checksum="A8A76565A315ABAB" modified="2013-03-06" version="1">MKQEMFYFQNNNTINKTMIVITLMNNKNDNIPQRGRPKKKISFFGANNNNLYAECNSAEMFGYNYGMNEEEIQGYGKEDGDSNAKGCSNDGYYGNYYNYQPYNYDMNGCYENAHNDTENGGNMESMESAGMAGGMENGGGSVNHGAVENSGMSVSSNMSHISNVNSMKRKMGEGMSMNVGMGALGGAGRGSHVIGHESGAAANPMNVSPGNGIVMNGGDMGMIHNTNVRLGNNVRIDSSHRQEGMSYGTLRRHDDGMSAGNGYANVPMNANGMVMPKMGANSAVNMNMGYNQMEYPGSYSNAAYNSGLGAGPGNDNFGYNLNHVAMNGNLGANNMMGGNQSHSSTSLNHPGQNQNGGNFQNCTPNMGNAPYNGAYYNYPYQNCPATPTNSTACTPYNKAPATVPATDTNNLFMNEMFMGHENAYINPWMNKKKRKNNPLLWQYIKQHQDFYPGIMHPSKYSSLDFVQGMNKTQKMYLGSIKRMPIIEKNNSNSILPLYLNSASILENSMHHTEFMRVSKSFFARIKNLDYENVTVQQLKNIMKEFGLNHTGKKIDLIERVKSTKVLIGEKLKEEKADKKGDEKESTMDSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYR1</accession>
    <name>L7JYR1_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993834">
        <property type="protein sequence ID" value="ELQ76574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0439"/>
    <dbReference type="HOGENOM" id="CLU_1714604_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYR1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="154" mass="17557" checksum="74E41E30EC6454EF" modified="2013-03-06" version="1" fragment="single">MSVAKDEESAANMDDRRKTERRDKNKTKSEIVQKSDEEKVKSSSKTRENRKDSPRSSKKRALKGENTAEAVCTGIFVGNEKRVKTNKNEEKAVEIENDELPSSTPRRTKQKAVKRIKMPKDDKTLSDDVREEEEPVKKTKITMKDAATEKEESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYS8</accession>
    <name>L7JYS8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993866">
        <property type="protein sequence ID" value="ELQ76171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYS8"/>
    <dbReference type="FunCoup" id="L7JYS8">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JYS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0868"/>
    <dbReference type="HOGENOM" id="CLU_055194_2_0_1"/>
    <dbReference type="InParanoid" id="L7JYS8"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="268" mass="31159" checksum="45EC041EB7B3546C" modified="2013-03-06" version="1">MARPELKNSPTQFYTNEEVEKYDRNKRIIYIQRKMAEKCCELINCTSGVILDIGCGTGHSISALKEYESSRNEKSEDALDKNRKLFIVGCDINRNMLLNCNNKGLDAELVQLDIGNSLPFQPASFDGIISVSCIQWLFYASNTDRTEKRLYMFLSSMYAALKREASACLQFYYEGKWQVDLLMKVSRRVGFVGGVVIDGEGKNTKYYLVLSMIVKNTKFEKADEEVLNRRKQRRCNSNYKIKERRDDNLYNNKRKKNDGRDKKKKKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYY7</accession>
    <name>L7JYY7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993840">
        <property type="protein sequence ID" value="ELQ76540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0477"/>
    <dbReference type="HOGENOM" id="CLU_592100_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYY7"/>
    <dbReference type="OMA" id="HISEERN"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="531" mass="62557" checksum="8EA806A0D701995D" modified="2013-03-06" version="1">MMTVIFRRFPSWYKNIREKVLKLPMKRLIEILVIMLCCKASIIHEEKKNTRKHCELKPPRPANEHESCNLTVHTEINDNKHDITHDSECVEVKTGFATKETPGGNEIPTDSSLVVQNESKREVCNMKDKSSKKATMGCFSKIFYRNHKRRNAAETDEDVDEKETPKEFDLATTSNPVKPESIDSQDSTMFKSKIEVLSRTTVDFHAKDSIKHISEERNRFPQAINNSNPTRLAKQHFSESITRCDVTTPNTNVRSTTHNLFFKAENFVQYATMRDTERNIMNEIEEIRIIEKQLENNEFAQDFLFKWHSLLCRKCLIELDATAVKLFIGYPSVYYECVYLPHSLRELIAWYHDSTYRLIKLYESLYRAIQNLRRYQNNLLAFETMLIRINYHYQIVYKEFGLSAKPKQSLDNVISYMFETYTKIRNKHTIYATKGIFDEIRMLVVECTDLLLNHLSICVKIRPYIADLIGSVEFYCYMITLTRFTQFLAETDHFFSNEKDGLFYFYPSYSNKGVMFKDFLNYIEYVNTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYZ3</accession>
    <name>L7JYZ3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993858">
        <property type="protein sequence ID" value="ELQ76256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0767"/>
    <dbReference type="HOGENOM" id="CLU_895916_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYZ3"/>
    <dbReference type="OrthoDB" id="10536174at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="311" mass="36969" checksum="B0AC303C45661DDB" modified="2013-03-06" version="1" fragment="single">VPDQETRRILDLQMKDILDMELCTDYMKLLRMKYEVKAFLPYLTLLNEWNVISLKHDENTIRVTMKSATAEFWAAVNQDVKTDVHLTISERERFFETCKSIEEKGFYRECLFVINRDYDAEKAKILSARLTALKKQIPSIYDSDLGKTLFLPQVLYRPYIDVKKDLMLNGHIDIKKYKFVDLETILMFMRERRIICEYRACTSAIEFTNTFKLKINVTMYNITFPEQLNRSEGRNEEMHAYHLKYLNLVYYTLLRAGSLDIDRLSEMITVLEPFEILEFVKHFNTLFKTTTIDEKVVVCICENEEVQLKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ13</accession>
    <name>L7JZ13_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993836">
        <property type="protein sequence ID" value="ELQ76570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0449"/>
    <dbReference type="HOGENOM" id="CLU_2795740_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ13"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="68" mass="7876" checksum="12A8A2F8C877FDA7" modified="2013-03-06" version="1">MSVVSLTVTSDVKFSDDELYIVVDRLLTFLHDKRPFLRVLAQQFLDNPELGDRLDIIDKASIKKRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ15</accession>
    <name>L7JZ15_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNF2 family DNA-dependent ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993857">
        <property type="protein sequence ID" value="ELQ76286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0736"/>
    <dbReference type="HOGENOM" id="CLU_334057_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ15"/>
    <dbReference type="OrthoDB" id="2195682at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="855" mass="96525" checksum="8177E0580CB741EB" modified="2013-03-06" version="1">MIRKTLGMETDMVRKDIVVENDIRMDKVEVVGRRKRVERKVEDVCTFFECLEDGMVEMDWKEREGCFLVYCGIFEGMRGITCAYDDNGNDSNDGNDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPLTLTTNPNLITRTLPYTHTISSTLLQTTINILYNDKFSDYQSDRTSLPVRQAAAHLLSFIYQKDVLDQLFMFLDHPDWEVQCSALLALKSVQHKLSSTDKKDVALCLLTLLESEDEDVKCMAADMLVHFKGVVGDVRVKMVVDEGVSRLGVVRMMECYCVRVGEGLSVDGCFRSEMVELRIAVLEYLRTMFRKGLVYDSCREDEGIVEDGDRKGEGNVEDGDRKGEGLVYDSCREGEKVNVKGSDRGKDGNVNSNVSSKDSNVNVKDGNVNVKNGINTNTSTNPPTSTNPILTNTNPSNIIIHHHYVHFINLLIQNILIEETPSLTFLTFNILPYYPINHVLSYVPLVLKPLNYVFKNTDFKNSLEMIDNAFSKGGVESMGREKVLVMRMRYFMYFCYLGVFKGTGKECKDEDDIIRWSCHDSGDVNGRDNDDGVGRDNDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYHVLVQPYVPFLYLPYHYHPSNHSSYPSSTKRCTSHQTYPTQPHRSSRVNGMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ45</accession>
    <name>L7JZ45_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LRR containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993831">
        <property type="protein sequence ID" value="ELQ76718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0289"/>
    <dbReference type="HOGENOM" id="CLU_1442014_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ45"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="188" mass="21568" checksum="F04B9F54B35BC3FF" modified="2013-03-06" version="1">MSLLISIFGTKERITQFKKHVRSHITFVLMDEKHFTVKLYGQSLSNSYHRLSMDQDGFTLVFLFDKVEIEYGWLVNNGNVLDIIFNNNMISSPYTIIINDEGKIFDAAKGIDIFKRISSIISTSKFLTGQNVSQLMLKFKNPYDNIDMLYLTDINASANALCIHFPFNFTKSLPKCAKIDVYIDDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ84</accession>
    <name>L7JZ84_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Puromycin-sensitive aminopeptidase</fullName>
            <ecNumber evidence="13">3.4.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_0251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="13"/>
    <dbReference type="EMBL" id="JH993817">
        <property type="protein sequence ID" value="ELQ76758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZ84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0251"/>
    <dbReference type="HOGENOM" id="CLU_501717_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ84"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="11">
        <location>
            <begin position="76"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ76758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="543" mass="61629" checksum="618DA0ADF1D4A09F" modified="2013-03-06" version="1">MKATFDIDITADEKFTILSNMSAKNETVKDGRKTVIFNHMKKTSTYLIAFVIGDLQKITEGRVSVYSTYDVNQGEYALRVADQVLKFFEEYFGIEYPLDKLDMVAVPEFLAGAMENWGLITYRETGLLFNKEKSSMTQRKLIAGTVAHEIAHQWFGNLVTPRWWDDLWLNEGFATWAAALGCNAIREKQKNDPSIVNPVNKNEPLIDWEPWVSFINDDLNKGMESDMLDSSHPIKVPVHHHKDVTQISGAILYSKSASLIRMVENYLGAEVFRKKIGRYLRKYSYGNASSKDLFEFLSDDNNNITKFMEIWTTQTGYPLVTLKDDTLVQTRMTLRKESDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZA2</accession>
    <name>L7JZA2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Pleckstrin like-type, Pleckstrin like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993877">
        <property type="protein sequence ID" value="ELQ76087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0950"/>
    <dbReference type="HOGENOM" id="CLU_1143236_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZA2"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="140"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="243" mass="28869" checksum="E50EA79553A48B07" modified="2013-03-06" version="1">MKNAQKKEEEEEINKRVEERIKTEREEEMKKEEQIKKEEEEKVKEEQKTKEEEIKKEEEMKKEEEHKGTAAGAQQDDKQKKVHFEEQKNEQRDVSKDPSKSIQSPTQEQPRPQVEINTGAVPLSALAPNTELFILRTTNKIVLEGPISKRMLFFSCFWHKRYFVLTNDGMLCYFRALNGRGKGKLNLRHVNDVRRINEETSGANKYKIILRYNGYTESIRFDDERVRDHWNNKIREVRDTLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZD0</accession>
    <name>L7JZD0_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993873">
        <property type="protein sequence ID" value="ELQ76117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0913"/>
    <dbReference type="HOGENOM" id="CLU_1876887_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZD0"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="136" mass="16086" checksum="E46A2AF221D9BEAF" modified="2013-03-06" version="1">MFGVDLNFANRVNQHNRNEVDDIVELSCKPLVEKEIAFAPIYPYEESIVEERREFREPVLESIKVNLQVDNEPINETCEYPKGNIVKICSFIYENRNLANKSDEIKNLAKEVEEEMLRNVSEHEKKYFERVLPSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZE8</accession>
    <name>L7JZE8_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993870">
        <property type="protein sequence ID" value="ELQ76132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0893"/>
    <dbReference type="HOGENOM" id="CLU_2484915_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZE8"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="87" mass="10225" checksum="8301113A3DFF0A63" modified="2013-03-06" version="1">MKEKEVETKNVALSVKNQSEEHIPVHADADRNDEKQIYDKHVVRVDFERSATILDFNPIYPYYKAEPIIKISLNEMRKDKHGKNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZM5</accession>
    <name>L7JZM5_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">THOM_0115</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZM5"/>
    <dbReference type="FunCoup" id="L7JZM5">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0115"/>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="InParanoid" id="L7JZM5"/>
    <dbReference type="OMA" id="NTYEPTH"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 19" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16 18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 19" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="144"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <ligand>
            <name>GTP</name>
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        <ligand>
            <name>GTP</name>
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        <location>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ELQ76918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="219" mass="25154" checksum="1E2B83928EDF825F" modified="2013-03-06" version="1">MTAVQTFFSNLKNRILEVYENTIAGFIRSIFSKPSSILFLGIDNAGKTTLLHKLKEDVTNTYEPTHHPMNSEIEIGNMKANIMDLGGHQSARLAWQEFFYNCDGIVFIVDVNDTKRYHLVREVYQSVREIQVGKKKPPIAVLMNKIDLIKHDANSILQDQDVMDQIQKETGIENDDSLEQPVLVTYVSLLNESITDMSSPILQSFQWLDKMIHRRPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZV0</accession>
    <name>L7JZV0_TRAHO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993798">
        <property type="protein sequence ID" value="ELQ76988.1"/>
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    <dbReference type="HOGENOM" id="CLU_2456344_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZV0"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="ELQ76988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="9995" checksum="A834E9BE0B9448BC" modified="2013-03-06" version="1">MIKRNTAFLEQNDDSELCNRLINIHLTDDASSIQKNSNSDHTSIYKSGKCAFGTGTLEINEKKKCKGLNIDDNSGVGNSYNVRDWMFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZX2</accession>
    <name>L7JZX2_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">THOM_0742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="ELQ76292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979022" evidence="2">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ELQ76292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="128" mass="14901" checksum="DDCF5B04F82476A0" modified="2013-03-06" version="1">MLQLVILVYVLSIVTYNYEHTYTNILPLTHLHLTRNPILIRRITPQIVMSSYNQDENSLDEESEVQNDAKDKGGFMKKMKKMLSEFVEGVTIGKMLFFGFVVVICVLIGYQIRKREEQSNYVRLPNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZZ3</accession>
    <name>L7JZZ3_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">THOM_0091</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="JH993806">
        <property type="protein sequence ID" value="ELQ76895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZZ3"/>
    <dbReference type="FunCoup" id="L7JZZ3">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0091"/>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="InParanoid" id="L7JZZ3"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ELQ76895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="258" mass="30071" checksum="64A9780989A92E02" modified="2013-03-06" version="1">MPKMTDTVFLFDVDGTLTPSRKKIKPDMLQFLQELRTQVYIAFVGGSNLEKQQEQVCPEILTLFDFSFPENGLSYYRGTELVSKRCIKDFLGEEILQNFVNFCLHYLSTIKLPVKRGLFIEMRDSMVNVSPVGRTCNDEERQQFFEYDKQHKIRENMVQVLKKEFGKYDMHFCIGGQISIDCFPKGWDKRYCLQHLEGEGIKNVYFFGDMVHEGGNDYEIFEDDRVVGIPVSSPSDTFRKCKEVLEEAKLEHGMKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>L7K015</accession>
    <name>L7K015_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposable element encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993854">
        <property type="protein sequence ID" value="ELQ76367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K015"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0680"/>
    <dbReference type="HOGENOM" id="CLU_1595717_0_0_1"/>
    <dbReference type="InParanoid" id="L7K015"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="167" mass="18950" checksum="98BFB29488F3FC3D" modified="2013-03-06" version="1">MHGLKKYRDDFNVVLAALAPIKMLLVKSVLLLIATYGCELYGMSTARLVPLQRMIDHALKNVLSCGSSYCRKATYEVLRIDCVVMQAAKLRTRAFLNWKTSRTTIGELINQPFKCPSATWITGTKRWLHSLLHCEIPATQREAVRAGKSRMAERLLRIDRSVISSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7K072</accession>
    <name>L7K072_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993818">
        <property type="protein sequence ID" value="ELQ76746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K072"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0255"/>
    <dbReference type="HOGENOM" id="CLU_2887424_0_0_1"/>
    <dbReference type="InParanoid" id="L7K072"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="63" mass="6925" checksum="BF638F57247E3B92" modified="2013-03-06" version="1">MFIHLLYLAKILCELTPEETESTLRLLNSTLKEEISDAIKRGELMNAEGVPTFKSGAKKGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>L7K098</accession>
    <name>L7K098_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Microtubule-binding protein involved in cell cycle control</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993812">
        <property type="protein sequence ID" value="ELQ76821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K098"/>
    <dbReference type="STRING" id="72359.L7K098"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0175"/>
    <dbReference type="HOGENOM" id="CLU_077755_0_0_1"/>
    <dbReference type="InParanoid" id="L7K098"/>
    <dbReference type="OMA" id="NINTRTR"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="75"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="375" mass="44301" checksum="E1951527AF31E0FF" modified="2013-03-06" version="1" fragment="single">VFLKNAISKTRYLQFDTSNINRYNIHLYYFNCGYFYPLAERKIPRYFIRDLFHYSLHIYPCFVSMSTNYHKIQPPTTKSQLILFLSTVLNHSIPSIESLGSGVVYAQLLYKLYPDFPIRSINENPKTEQERFNNLKIVQRYLVKMNIVVVFPVEKMVGCRLQDNLEVAQWMVKHYFEVCYKEQKKVGSEKTSNVLIDCNNDKRRSSNSIEHTKEVKNKKHDRKRCYSGHENVYDQVKKEQSQLTNEVKHGHELGTKKCPDIITEISLNDQNSPTKLHIDSDISHHTVRKKIGAIRVREPVNNINTRTKDDTVHEDCRIQLESAEQKLKMAGEFIVQLEEERNFYYEKLLEIEKIVTLNNWENSKDTVLDILKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0C9</accession>
    <name>L7K0C9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Histone-fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0C9"/>
    <dbReference type="STRING" id="72359.L7K0C9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0322"/>
    <dbReference type="HOGENOM" id="CLU_150177_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0C9"/>
    <dbReference type="OMA" id="MQQFSRK"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="105" mass="12404" checksum="8FED5CEEF27F0F98" modified="2013-03-06" version="1">MQFKETVITPRDKLQNLINDTTEQPFDREVINRMQQFSRKFINDVLTRSALLSEHKNIGAITSEEIFYVVEKEFDFCFGDREILNTQKTPAVEHIDKMAELSRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0D3</accession>
    <name>L7K0D3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0D3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0333"/>
    <dbReference type="HOGENOM" id="CLU_1422352_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0D3"/>
    <dbReference type="OMA" id="WARHEYN"/>
    <dbReference type="OrthoDB" id="10361538at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="191" mass="23295" checksum="02D44191B4C53818" modified="2013-03-06" version="1">MFLLFVSFSYCYYSNDVLGSYKTDKPPFNPVDRHSWSYDRRNHEDNINFRNAKEIVRENPEPSYFDQQVQITNLFDAALSGYSSRFNKFRRINNRMNNIRLAIKQNECVVNDKYVGEEPLNVVSWLYEDNEEEKKMDKDLQREVENNVMHAKEKRDRLMIMAEEHLKNRRLEDREHKNRFLQWARHEYNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>L7K0J7</accession>
    <name>L7K0J7_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription elongation factor SPT6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993810">
        <property type="protein sequence ID" value="ELQ76852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K0J7"/>
    <dbReference type="STRING" id="72359.L7K0J7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0139"/>
    <dbReference type="HOGENOM" id="CLU_328190_0_0_1"/>
    <dbReference type="InParanoid" id="L7K0J7"/>
    <dbReference type="OMA" id="GWAEEGW"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="959" mass="110364" checksum="366C16C940E14EF1" modified="2013-03-06" version="1">MSASSEEEIYKRIRPAKKHDDLNNLFDEESSTPSNAYYDTEPANLEEIFGTGQEYAYIYAAHESAAQPAATKCARPYVAYSDVLRYARNNEITNTEIIKKLYDGYDVNFIALHCVNSYESGELMSVYDIYRMKEVIEGFPTFYRLRQMVQGVFGNRMWTVEGMRQLLMYEKYEDVVIKGVLRTDDFAENLFFEDRVSVPGNDEEEGLSDEELLGDEENGWAEEGWAEEGWAEEGWAKDRRAEEGWAEEGWGESNDKKSDEDRCDRKSENNNDGNEGKTNNGINNNGNGNGINNNGNGINNNDRNENIPSHKNNTNKESLRRKIKGYVLRMSKHPYLNTYARKYFDRKALLDKLCYYFGVDTDRPTRNDRLRKTIVSEIVAQMDSTRENVRDTHHDTFTAVLDAVLNTAVARPTQNDTYLCMTEDKGHAKIVVMNYLGNACRRMSVRNTEKSVVEVIKDVRPKYIFVTGRRTALRFFYSALVEWTDALLNAEGFHCTLMYADPFVYAEDVFEMLLHVGRRCLYPEIELMHIVSTNTLPYFVKDSSRCSLSAARRALTLGLAIVGIDLNYLMKCDRARIIAKFVPLFNAHVMRALAELGFVSRLEILKDVLCTPVEMDTRDDTFICFNAIDGEVLYANVCTYLRIYRSTFDVADRYNRLDELLVHPANYHSARMICAAAMDKEELDEDNNYNAALEQISEKGELGALDVERLRMKKDVFDILNVMMYKRTLFRGLCDAKVFEMLVGQYENDGVYAGSVIKVCDGYLIVRVHDNWCVFVRVAHEDSTRYFENDELKVRITEKNVLGLSFRGEIVHEAPFFLQSHPLYVDCTAAAAHNILRQRRQLLLLRKSSSKQYGVVTLRLTDEIFVHYKIEQDNGGVLFNNRRYENVDHVIYCYFREMVKILAEVMNDKDYGTVMRLSKKRPGYLEIGGECVCMGNVLRRGDEVFRSVGELKERLGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>L7JT57</accession>
    <name>L7JT57_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRM8</name>
        <name evidence="10" type="ORF">THOM_3138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="9"/>
    <dbReference type="EMBL" id="JH994096">
        <property type="protein sequence ID" value="ELQ73942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JT57"/>
    <dbReference type="FunCoup" id="L7JT57">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JT57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_3138"/>
    <dbReference type="HOGENOM" id="CLU_050910_3_1_1"/>
    <dbReference type="InParanoid" id="L7JT57"/>
    <dbReference type="OMA" id="LNVMKFG"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ELQ73942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="269" mass="30974" checksum="864B5F333C693555" modified="2013-03-06" version="1">MTMPKKSKYRQHAHANPFSVREMTIPSSPSNVNLPAANYVDVGCGYGRFLLHVAKTRPDKVVYGLEIRKKVYEFVRDKIAELRKNGVVEKHRSVSGTESKEIDDTPANTYEGLLVNGTQKEKVDEQQCIRENGKECVTYENAHVIRTNAMLFFLHFFKKRSLEKIFVLYPDPHFKNKKRKARMVTLQTIQCFDYCLAEHGRVYISTDVKELFTAMIDSFSNCAYFKRLSDSECCSDEFYDAIQIGTDESKRAGARALVIYSAIYEKRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>L7JUV4</accession>
    <name>L7JUV4_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_1811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993979">
        <property type="protein sequence ID" value="ELQ75248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JUV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1811"/>
    <dbReference type="HOGENOM" id="CLU_2456348_0_0_1"/>
    <dbReference type="InParanoid" id="L7JUV4"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ75248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="89" mass="9846" checksum="E1FBD4E88ABF4C5A" modified="2013-03-06" version="1">MGNAKQISVYDMVLKEYKKVSSAENSLLVTNANGTLVSVKIDGMLKIMKNLVDMGNIYNIDSVQSICFKNDNFIFIGTEGGLVKKYSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVR3</accession>
    <name>L7JVR3_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sirtuin 5, class III sirtuins (SIR2 family)</fullName>
            <ecNumber evidence="7">2.4.2.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_2231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.31" evidence="7"/>
    <dbReference type="EMBL" id="JH994017">
        <property type="protein sequence ID" value="ELQ74832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVR3"/>
    <dbReference type="FunCoup" id="L7JVR3">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JVR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_2231"/>
    <dbReference type="HOGENOM" id="CLU_316219_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVR3"/>
    <dbReference type="OMA" id="FHRANIR"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106274">
        <property type="term" value="F:NAD+-protein-arginine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="740"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="312"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="792"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ74832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="923" mass="103766" checksum="806B1F163433842C" modified="2013-03-06" version="1">MQKIDATYIKANKNLFLNKNTVIIVGAGLSVPSNIPDFRSTHGLFATLKQRYKIRGEHIFTYRFTIEKETRSTYLKVISELKRAVDAASPSAGHYFLNRMREIGRRLRVYTQNVDGLEERAGLRCTGDCSTEVVYLHGNLNVLVCSYCGYRCLFGGEHCDAFEKGCEVECERCLTKNYGQGRVRCINEDEVRAGKNSRGSSKGNAGGDEVRVAANTNGVSNSRVSNSKVSITNTKAINTTNNTNPSTNNSVNDRNTHLKDKPSIKKGINTHKEPEIEMEMIEQVQPKIQEIKNSSKDQQTLSHWHVKERRPSQGSTSSSNSSSGSNSSNGSNSSSSSNSSSSKFKPNLNSPSKSNLTSNPKSNPNSTNPLNPNSTNPSNPNHPTNPNPRSNPIPNPTITTKTNRKLITGMMNTNIIHYYQVHPDSHYIASLTRRDSNCQLLLVMGTSLKVHGVKQLVKYFSRVARANNGKSVFVNMESVCKNMMECFDLFYEGSIEEFFGVVGECVEGGEQKRLSMRNFVSVRSGARSDGVCRKGRDEEKGDFRKDKDGKGKDGKDKDGKGKDGKDKDGKDKDGKDKDGKDKDDEDEEKDKINIKDKDEEKGRIDVMNEENINIKDKISINDKISVEDKISVKDKVSSVTTVDSKILQKLKYNKVTTHNNTPKQENINKQCLLSTCRNDDLHQKDCKGPLKDNAHKNESISINACDNKEKIRIRKPRKDKNVNSKKESIECSSLKDVKLKIKESKEGDKNENKGKNDEGEENIKKKGRDVRKRRDNSDEEDKNENKGKKKGRDSNDEGSNKKGDKNDEGGEGEENIKKKENIKKKENIEKKENIKENVNDNPKKKENIKDNKDLNDTIDDKRTIRRMSLIRIKTKRTVIDDDNSTAIDEHVQKSVVLTPRKKVNKKKVSNACAVVKNKEKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>L7JVU9</accession>
    <name>L7JVU9_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA methylase</fullName>
            <ecNumber evidence="4">2.1.1.113</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">THOM_1487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.1.1.113" evidence="4"/>
    <dbReference type="EMBL" id="JH993943">
        <property type="protein sequence ID" value="ELQ75554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JVU9"/>
    <dbReference type="STRING" id="72359.L7JVU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1487"/>
    <dbReference type="HOGENOM" id="CLU_053196_0_0_1"/>
    <dbReference type="InParanoid" id="L7JVU9"/>
    <dbReference type="OMA" id="KLRTCER"/>
    <dbReference type="OrthoDB" id="2191663at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ELQ75554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="429" mass="49817" checksum="39D82D53761DE35A" modified="2013-03-06" version="1">MYTFLVRLVNTYQNFRFHEVLCLLRNYPHKIITKPQDMHPYMILETTFEAIREIGQKSIFVKQISYLLYVAETNHELLVVDETLKEKLQRKTEEFVKLYLTGELNRIQHNERVTTETAQKVKFKLVTETFGCKIKQKNDFSNKYCFLTSTELILRQPLTIIYVISCTLNKTYFSIHVMTSRRKEMLRYGVPNRLFIGHTAMDLEVSAFMFNITVSTGNCIILDPFVGSGSIILYCALMGCYVVGCDISKKQMIGQNTIEENNKKNLKSFDHDIKQMITSYSNKITSTVSSDEYYNVQDKLFLTKLPGVRTSLAGTSIHSNFYQFGVEERLLGIFRASIFSTHFKKVDHVITDLPYGIRASLQKETMISLIKGLRDLCDEVLHKNGRVCFSIIRGYGNEIARLFEAYELVLSVNQKLRTCERVFYLFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JW72</accession>
    <name>L7JW72_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_1793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993974">
        <property type="protein sequence ID" value="ELQ75296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JW72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_1793"/>
    <dbReference type="HOGENOM" id="CLU_1856806_0_0_1"/>
    <dbReference type="InParanoid" id="L7JW72"/>
    <dbReference type="OMA" id="AFSDACH"/>
    <dbReference type="OrthoDB" id="10382018at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ75296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="138" mass="16383" checksum="9F48773AF989B919" modified="2013-03-06" version="1">MIFKKHERYPLKLILYTKLHSKERKNTKKPSTSAFSDACHVISSKLHALSNLILEADRFPSKEMKELIDELLKLKRMEVNMAVPLSVIEMLDDGKDFDAIFNEREKEELEERKENVKKEERTNTFYEKLDKLNLTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>L7JXE8</accession>
    <name>L7JXE8_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">THOM_0939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="JH993875">
        <property type="protein sequence ID" value="ELQ76104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JXE8"/>
    <dbReference type="STRING" id="72359.L7JXE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0939"/>
    <dbReference type="HOGENOM" id="CLU_664269_0_0_1"/>
    <dbReference type="InParanoid" id="L7JXE8"/>
    <dbReference type="OMA" id="THSYVWY"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="12">
        <location>
            <begin position="62"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ELQ76104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="414" mass="45565" checksum="58DD6F21AB7FD91A" modified="2013-03-06" version="1">MKKLHITKKRSNTKSKNTYAIKTHTATDTRVIGDKIFTPRADDNPSVNKNILCANVKCTGTRIVIGIDEAGRGPVLGYLVYAALLVNEDDATSTSDYVSVRTDEARVETEVGPETGAGTGAGTKTRVGTGAGTKTRVGTGAGTGAGTKTRAGTETGVGTETGVGTGTRTEIKGNKTKGTETKTRPTKEPNVNKVTNTMSTHKETIRMCDSKQLLPKQRESIYEQIITTHSYVWYALHPQYISTEMDRRNLNDISISAVIHILTTILNALDQPNSNTNQPNSNTKPSRKDNQTRAAHTITKVYVDALGSTNKYEHILRQHFPHIPFVVEYKADSTYRCVGGASIVAKVVRDDLLRRFSVQCGSGYPSDWRTVGWLSTNRESEMVRFKWAGVKREQESRTSARVHGKYSTLHFCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>L7JY70</accession>
    <name>L7JY70_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">THOM_0640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JH993853">
        <property type="protein sequence ID" value="ELQ76384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JY70"/>
    <dbReference type="FunCoup" id="L7JY70">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JY70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0640"/>
    <dbReference type="HOGENOM" id="CLU_032621_0_1_1"/>
    <dbReference type="InParanoid" id="L7JY70"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ELQ76384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="419" mass="48502" checksum="C5127E17465B4BC7" modified="2013-03-06" version="1" fragment="single">VVFLPLMKEILTPWDVAQVQLDYQKITDQFGCELINDDLIAKMEKLTGKKVSHLIKRRIVFAHRDLGKILDDYERGRGFYLYTGRGPSTKSMHIGHVIPFMLCKYLQDIFDVPLVIQITDDEKYLFKDLQISESVEFAKSNIKDIIAFGFNPEKTFIFSNVGIYDGNEDITDSKNEVYQEGECLNCESSKIRNTSQKKKPFNGFFKKELVLAKSITFHEGSKVFGFDSSTNLGQISFPVRQLLPCFYSVFTFLKNSNCLVPAAIDQDPYFRLARDKSKIFECSKPSTIYSQFLPSLMNLGKMSSSKDKTIFLDDSEESIKKKIRTYAHSGGRKTLQEHKMLGGDLDNDVSYQYLRFFMEDEDKLQSVADKYKKGEMSSMEMKDLCIEELQKFVRTYRKRRDRVSDEDVAKFMGCDKDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYA5</accession>
    <name>L7JYA5_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">THOM_0601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993849">
        <property type="protein sequence ID" value="ELQ76414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0601"/>
    <dbReference type="HOGENOM" id="CLU_072831_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYA5"/>
    <dbReference type="OMA" id="YTMFTSA"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ELQ76414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="241" mass="28441" checksum="A690C0A6B18FFC4F" modified="2013-03-06" version="1" fragment="single">VLKLLLYVNQRGIKPLRIPSNIPVSDYFIRKYIVTENYIQTEKILSQQKKKITTQSYTQLKLTVNKRIGQITTDIDHINLITQHLKQYDSCIFYELLTIKILEQAKLQVSNCFETYKSYGWLLNNLYTPNLHSLFLVGLMCKKEEGKLLKSMYSIYFELLRLRQLWIEAYDFFAGVLNEVPASHSFHVVEAYLLVLGQDMSMVFGKKFRGVINYIRDEYFPRGDNKPCKVRIEKIIENLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>L7JYH1</accession>
    <name>L7JYH1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993845">
        <property type="protein sequence ID" value="ELQ76513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JYH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0541"/>
    <dbReference type="HOGENOM" id="CLU_2051300_0_0_1"/>
    <dbReference type="InParanoid" id="L7JYH1"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003979137" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13892" checksum="A6524C40CBD3DE9E" modified="2013-03-06" version="1">MQFLGFFLIVYAACCALIHEKAKEVKSEKRGACGNKKILGAPTKILPELDKLEKYLKEYYSVANDVVDAFNSLVLRADLNEARFHIQLRKLLHQCKQHMNNTTNFKKLYCYPLEIIVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZ60</accession>
    <name>L7JZ60_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">THOM_0962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="JH993885">
        <property type="protein sequence ID" value="ELQ76052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZ60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0962"/>
    <dbReference type="HOGENOM" id="CLU_3126084_0_0_1"/>
    <dbReference type="InParanoid" id="L7JZ60"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ELQ76052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="50" mass="5795" checksum="AE344B99502AF1DC" modified="2013-03-06" version="1">MIRMRDIALVSGGVVRNVCVKRLWIIFFDGVGYFFYFVRVYFTLGIGLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>L7JZT1</accession>
    <name>L7JZT1_TRAHO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">THOM_0462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JH993838">
        <property type="protein sequence ID" value="ELQ76551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7JZT1"/>
    <dbReference type="FunCoup" id="L7JZT1">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7JZT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0462"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="L7JZT1"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000346">
        <property type="term" value="C:transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="56"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="242"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ELQ76551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="397" mass="44859" checksum="354FD0129E7F3CBC" modified="2013-03-06" version="1">MSDEELIEYAETVQTEKTKNTDVISSFPELLLKDELIKAIRDANLEHPSAVQQQVIPKAVLGADIICQAKSGTGKTVVFVLSALQRINAEDVSPARVQVMAVANTKEMVVQIANEFRRFMSYTDLKVEMVFGGVDVNGDVEKLKARVDVVVGTPGRLFDLIQRGALDVSALRILIIDEVDSILSSLSSRWTVQRIIYRTPVAKQTMLFTATLSNEMKSTCLLMVRNPFVLQVDEERKLTLHGLEQGYVNVIEDNKRDKLIGLIDSIRDISQCVIFCRDKRRVEVLCEHLKTKGLPAVAITSDYDTNERMQRFMSFKNLNYRFLVTTNLMARGIDIAEINLVVNYDMAEDAQTYLHRVGRAGRFETRGTAVSFICNEEDIVVLNEVQERFEVSIKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>L7K062</accession>
    <name>L7K062_TRAHO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID, subunit TAF6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">THOM_0437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trachipleistophora hominis</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="72359"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Pleistophoridae</taxon>
            <taxon>Trachipleistophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002979" last="E1002979">
            <title>The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.</title>
            <authorList>
                <person name="Heinz E."/>
                <person name="Williams T.A."/>
                <person name="Nakjang S."/>
                <person name="Noel C.J."/>
                <person name="Swan D.C."/>
                <person name="Goldberg A.V."/>
                <person name="Harris S.R."/>
                <person name="Weinmaier T."/>
                <person name="Markert S."/>
                <person name="Becher D."/>
                <person name="Bernhardt J."/>
                <person name="Dagan T."/>
                <person name="Hacker C."/>
                <person name="Lucocq J.M."/>
                <person name="Schweder T."/>
                <person name="Rattei T."/>
                <person name="Hall N."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133373"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH993832">
        <property type="protein sequence ID" value="ELQ76716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L7K062"/>
    <dbReference type="FunCoup" id="L7K062">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="72359.L7K062"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:THOM_0437"/>
    <dbReference type="HOGENOM" id="CLU_021711_3_1_1"/>
    <dbReference type="InParanoid" id="L7K062"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000011185">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000144">
        <property type="term" value="P:positive regulation of DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="6">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ELQ76716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011185"/>
        </source>
    </evidence>
    <sequence length="389" mass="45042" checksum="16F172EE9DC0608F" modified="2013-03-06" version="1" fragment="single">VNYSIYCKTCRFYYARKTPLKNYPMLFNKDSFLAYAQAKGLEIEDEAVSILAQDVEYRVKELCQEAAKFMLFSKRTKLSIDDVNNALVTRNVDPIFGYDPKDNLIFKNDIVKSAIFYVPDEEVDLEDFLNQPLPKMPLKPKITSHWLAIEGVQPQIPQNPIIMEKPSLKQDPLVTYTEESELKQTTKHVISKELQLYYEKILSFLEDNEKITLAIECLKTESGIQQLIPYLIQNINEKILKNMESDLLSNFILFYHSLLQNEHIFIDPYLHQIIPSLLTCIIGKRVKNVDIRKLAAETIKYVYDKYAITYDTLGPRIIKTLTKVWLDKDKSEDAHYSALFTLSILSRNVVSSVILKEKDGYVEMAKELGYERVLQLLSDILAKNQTNVV</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>